Gene table of MDM2 : MDM2 proto-oncogene

Gene-disease associations table

Disease IDDisease nameSource of annotation with MDM2OMIM linkNumber of associated genesgenes
614401ACCELERATED TUMOR FORMATION, SUSCEPTIBILITY TOClinVar, OMIM link to OMIM 1MDM2

Download the gene annotation in CSV format

Annotation of the gene MDM2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Ubiquitin mediated proteolysishsa041205.63
Melanomahsa052186.56
Bladder cancerhsa052197.38
Prostate cancerhsa052156.11
Proteoglycans in cancerhsa052055.02
Cell cyclehsa041105.68
MicroRNAs in cancerhsa052065.38
Pathways in cancerhsa052003.98
Gliomahsa052146.66
p53 signaling pathwayhsa041156.56
Endocytosishsa041444.92
FoxO signaling pathwayhsa040685.63
Chronic myeloid leukemiahsa052206.48
Viral carcinogenesishsa052035.08
Thyroid hormone signaling pathwayhsa049195.82
Transcriptional misregulation in cancerhsa052025.21
Epstein-Barr virus infectionhsa051694.97
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Oncogene Induced SenescenceR-HSA-25595858.03
PI3K/AKT activationR-HSA-1982036.32
Cellular SenescenceR-HSA-25595835.7
Immune SystemR-HSA-1682562.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Trafficking of AMPA receptorsR-HSA-3997198.08
Downstream signal transductionR-HSA-1867634.65
GAB1 signalosomeR-HSA-1802926.31
Cell CycleR-HSA-16401703.89
Signaling by ERBB4R-HSA-12363944.7
Adaptive Immune SystemR-HSA-12802183.19
DiseaseR-HSA-16436853.33
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Cell Cycle CheckpointsR-HSA-696205.64
Downstream signaling of activated FGFR1R-HSA-56546874.71
PIP3 activates AKT signalingR-HSA-12576046.37
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Cellular responses to stressR-HSA-22627524.56
Signaling by EGFRR-HSA-1779294.59
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
Constitutive Signaling by AKT1 E17K in CancerR-HSA-56744008.4
Stabilization of p53R-HSA-695417.28
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
Neuronal SystemR-HSA-1123164.82
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
Downstream signaling of activated FGFR3R-HSA-56547084.71
Transmission across Chemical SynapsesR-HSA-1123155.28
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Innate Immune SystemR-HSA-1682493.17
Signaling by SCF-KITR-HSA-14335574.73
Signaling by ERBB2R-HSA-12279864.66
PI3K events in ERBB2 signalingR-HSA-19636426.37
AKT phosphorylates targets in the cytosolR-HSA-1983239.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.85
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityR-HSA-3997218.08
Oxidative Stress Induced SenescenceR-HSA-25595806.51
Signalling by NGFR-HSA-1665204.23
Signaling by FGFR2R-HSA-56547384.68
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
G1/S DNA Damage CheckpointsR-HSA-696157.08
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by PDGFR-HSA-1867974.53
Signal TransductionR-HSA-1625821.78
DAP12 signalingR-HSA-24244914.64
Associated GO terms for Molecular function
GO termGO IDGO IC
ubiquitin-like protein ligase bindingGO:00443894.15
enzyme bindingGO:00198992.27
bindingGO:00054880.18
ubiquitin-like protein transferase activityGO:00197873.69
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
ligase activityGO:00168743.72
SUMO transferase activityGO:00197897.03
ion bindingGO:00431671.36
transferase activityGO:00167401.95
metal ion bindingGO:00468721.41
identical protein bindingGO:00428022.63
catalytic activityGO:00038241.05
ubiquitin-protein transferase activityGO:00048423.73
ubiquitin protein ligase activityGO:00616304.47
ubiquitin-like protein ligase activityGO:00616594.44
ubiquitin protein ligase bindingGO:00316254.17
scaffold protein bindingGO:00971105.93
protein bindingGO:00055150.46
peroxisome proliferator activated receptor bindingGO:00429757.03
receptor bindingGO:00051022.43
p53 bindingGO:00020395.53
zinc ion bindingGO:00082702.66