Gene table of DNMT3A : DNA methyltransferase 3 alpha

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DNMT3A	OMIM link	Number of associated genes	genes
615879	TATTON-BROWN-RAHMAN SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	DNMT3A

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Metabolic pathways	hsa01100	2.49
Cysteine and methionine metabolism	hsa00270	7.56
MicroRNAs in cancer	hsa05206	5.38

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
DNA methylation	R-HSA-5334118	8.03
Epigenetic regulation of gene expression	R-HSA-212165	6.46
PRC2 methylates histones and DNA	R-HSA-212300	7.7
Chromatin organization	R-HSA-4839726	5.19
Gene Expression	R-HSA-74160	2.72
RMTs methylate histone arginines	R-HSA-3214858	7.49
Chromatin modifying enzymes	R-HSA-3247509	5.19

Associated GO terms for Molecular function

GO term	GO ID	GO IC
unmethylated CpG binding	GO:0045322	7.95
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
methyltransferase activity	GO:0008168	4.35
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	GO:0051718	8.64
ion binding	GO:0043167	1.36
DNA (cytosine-5-)-methyltransferase activity	GO:0003886	8.35
transferase activity	GO:0016740	1.95
transferase activity, transferring one-carbon groups	GO:0016741	4.3
metal ion binding	GO:0046872	1.41
identical protein binding	GO:0042802	2.63
cation binding	GO:0043169	1.4
S-adenosylmethionine-dependent methyltransferase activity	GO:0008757	4.81
catalytic activity	GO:0003824	1.05
organic cyclic compound binding	GO:0097159	1.05
DNA-methyltransferase activity	GO:0009008	8.13
protein binding	GO:0005515	0.46
chromatin binding	GO:0003682	3.64