Gene table of TP53 : tumor protein p53

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TP53	OMIM link	Number of associated genes	genes
PS151623	LI-FRAUMENI SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	TP53, CDKN2A, CHEK2
114550	HEPATOCELLULAR CARCINOMA	ClinVar, OMIM	link to OMIM	11	CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1
260500	PAPILLOMA OF CHOROID PLEXUS	ClinVar, OMIM	link to OMIM	1	TP53
614740	BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 7	ClinVar, OMIM	link to OMIM	1	TP53
259500	OSTEOGENIC SARCOMA	ClinVar, OMIM	link to OMIM	3	TP53, RB1, CHEK2
114480	BREAST CANCER	OMIM	link to OMIM	27	RB1CC1, ESR1, NBN, PALB2, SLC22A18, BRIP1, BCPR, CASP8, FAM175A, TSG101, CHEK2, BARD1, TP53, AKT1, BRCA1, PIK3CA, PHB, PPM1D, NQO2, ATM, RAD51, BRCA2, CDH1, XRCC3, HMMR, KRAS, RAD54L
260350	PANCREATIC CANCER	ClinVar, OMIM	link to OMIM	6	STK11, KRAS, ACVR1B, RBBP8, SMAD4, TP53
202300	ADRENOCORTICAL CARCINOMA, HEREDITARY	OMIM	link to OMIM	1	TP53
PS137800	GLIOMA	ClinVar, OMIM	link to OMIM	8	PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53
607107	NASOPHARYNGEAL CARCINOMA	ClinVar, OMIM	link to OMIM	1	TP53
605027	LYMPHOMA, NON-HODGKIN, FAMILIAL	ClinVar	link to OMIM	7	RAD54B, BRAF, BCL10, TP53, CASP10, PRF1, RAD54L
114500	COLORECTAL CANCER	ClinVar, OMIM	link to OMIM	30	TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B

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Annotation of the gene TP53

Associated genes in ENSEMBL

ENSG00000141510

Associated proteins - SwissProt Accession ID

P04637

Associated PDB IDs

Cytogenetic Band

17p13.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Bladder cancer	hsa05219	7.38
Pancreatic cancer	hsa05212	6.56
Endometrial cancer	hsa05213	6.81
Colorectal cancer	hsa05210	6.52
MAPK signaling pathway	hsa04010	4.63
Thyroid cancer	hsa05216	7.48
Basal cell carcinoma	hsa05217	6.79
Glioma	hsa05214	6.66
Prostate cancer	hsa05215	6.11
Neurotrophin signaling pathway	hsa04722	5.78
Central carbon metabolism in cancer	hsa05230	6.7
Herpes simplex infection	hsa05168	5.08
Epstein-Barr virus infection	hsa05169	4.97
Apoptosis	hsa04210	6.23
HTLV-I infection	hsa05166	4.59
Hepatitis C	hsa05160	5.68
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
Proteoglycans in cancer	hsa05205	5.02
Cell cycle	hsa04110	5.68
MicroRNAs in cancer	hsa05206	5.38
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
p53 signaling pathway	hsa04115	6.56
Non-small cell lung cancer	hsa05223	6.88
Small cell lung cancer	hsa05222	6.17
Chronic myeloid leukemia	hsa05220	6.48
Thyroid hormone signaling pathway	hsa04919	5.82
PI3K-Akt signaling pathway	hsa04151	4.21
Wnt signaling pathway	hsa04310	5.49
Transcriptional misregulation in cancer	hsa05202	5.21
Amyotrophic lateral sclerosis (ALS)	hsa05014	7.01
Huntington's disease	hsa05016	5.17

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Oncogene Induced Senescence	R-HSA-2559585	8.03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.98
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.15
Oxidative Stress Induced Senescence	R-HSA-2559580	6.51
Activation of PUMA and translocation to mitochondria	R-HSA-139915	10.98
Transcriptional Regulation by TP53	R-HSA-3700989	6.73
Signaling by NOTCH	R-HSA-157118	6.2
Programmed Cell Death	R-HSA-5357801	5.65
Cell Cycle	R-HSA-1640170	3.89
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88
p53-Dependent G1 DNA Damage Response	R-HSA-69563	7.15
Cellular Senescence	R-HSA-2559583	5.7
Generic Transcription Pathway	R-HSA-212436	3.86
Gene Expression	R-HSA-74160	2.72
Cellular responses to stress	R-HSA-2262752	4.56
Cell Cycle Checkpoints	R-HSA-69620	5.64
Transcriptional activation of p53 responsive genes	R-HSA-69560	11.98
Stabilization of p53	R-HSA-69541	7.28
p53-Dependent G1/S DNA damage checkpoint	R-HSA-69580	7.15
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73
Transcriptional activation of cell cycle inhibitor p21	R-HSA-69895	11.98
Activation of NOXA and translocation to mitochondria	R-HSA-111448	10.98
Activation of BH3-only proteins	R-HSA-114452	8.34
Pre-NOTCH Expression and Processing	R-HSA-1912422	7.49
Autodegradation of the E3 ubiquitin ligase COP1	R-HSA-349425	7.31
Pre-NOTCH Transcription and Translation	R-HSA-1912408	8.12
G1/S DNA Damage Checkpoints	R-HSA-69615	7.08
Apoptosis	R-HSA-109581	5.68
Intrinsic Pathway for Apoptosis	R-HSA-109606	7.73
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ubiquitin-like protein ligase binding	GO:0044389	4.15
purine ribonucleoside triphosphate binding	GO:0035639	2.22
cation binding	GO:0043169	1.4
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transition metal ion binding	GO:0046914	2.48
transcription regulatory region DNA binding	GO:0044212	3.03
chaperone binding	GO:0051087	5.34
receptor tyrosine kinase binding	GO:0030971	5.77
ion binding	GO:0043167	1.36
identical protein binding	GO:0042802	2.63
purine nucleoside binding	GO:0001883	2.22
protease binding	GO:0002020	5.08
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
double-stranded DNA binding	GO:0003690	3.09
copper ion binding	GO:0005507	5.71
protein tyrosine kinase binding	GO:1990782	5.7
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
RNA polymerase II transcription factor binding	GO:0001085	5.08
protein heterodimerization activity	GO:0046982	3.64
transcription factor binding	GO:0008134	3.46
regulatory region nucleic acid binding	GO:0001067	3.03
histone acetyltransferase binding	GO:0035035	6.41
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
protein phosphatase binding	GO:0019903	4.93
ubiquitin protein ligase binding	GO:0031625	4.17
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
receptor binding	GO:0005102	2.43
protein self-association	GO:0043621	5.93
protein phosphatase 2A binding	GO:0051721	6.41
small molecule binding	GO:0036094	1.89
metal ion binding	GO:0046872	1.41
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
protein N-terminus binding	GO:0047485	5.11
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
nucleic acid binding transcription factor activity	GO:0001071	2.65
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
purine ribonucleoside binding	GO:0032550	2.22
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
phosphatase binding	GO:0019902	4.63
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
p53 binding	GO:0002039	5.53
damaged DNA binding	GO:0003684	5.58
ribonucleotide binding	GO:0032553	2.19
zinc ion binding	GO:0008270	2.66