Gene table of TP53 : tumor protein p53

Gene-disease associations table

Disease IDDisease nameSource of annotation with TP53OMIM linkNumber of associated genesgenes
PS151623LI-FRAUMENI SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 3TP53, CDKN2A, CHEK2
114550HEPATOCELLULAR CARCINOMAClinVar, OMIM link to OMIM 11CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1
260500PAPILLOMA OF CHOROID PLEXUSClinVar, OMIM link to OMIM 1TP53
614740BASAL CELL CARCINOMA, SUSCEPTIBILITY TO, 7ClinVar, OMIM link to OMIM 1TP53
259500OSTEOGENIC SARCOMAClinVar, OMIM link to OMIM 3TP53, RB1, CHEK2
114480BREAST CANCEROMIM link to OMIM 27RB1CC1, ESR1, NBN, PALB2, SLC22A18, BRIP1, BCPR, CASP8, FAM175A, TSG101, CHEK2, BARD1, TP53, AKT1, BRCA1, PIK3CA, PHB, PPM1D, NQO2, ATM, RAD51, BRCA2, CDH1, XRCC3, HMMR, KRAS, RAD54L
260350PANCREATIC CANCERClinVar, OMIM link to OMIM 6STK11, KRAS, ACVR1B, RBBP8, SMAD4, TP53
202300ADRENOCORTICAL CARCINOMA, HEREDITARYOMIM link to OMIM 1TP53
PS137800GLIOMAClinVar, OMIM link to OMIM 8PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53
607107NASOPHARYNGEAL CARCINOMAClinVar, OMIM link to OMIM 1TP53
605027LYMPHOMA, NON-HODGKIN, FAMILIALClinVar link to OMIM 7RAD54B, BRAF, BCL10, TP53, CASP10, PRF1, RAD54L
114500COLORECTAL CANCERClinVar, OMIM link to OMIM 30TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B

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Annotation of the gene TP53

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Bladder cancerhsa052197.38
Pancreatic cancerhsa052126.56
Endometrial cancerhsa052136.81
Colorectal cancerhsa052106.52
MAPK signaling pathwayhsa040104.63
Thyroid cancerhsa052167.48
Basal cell carcinomahsa052176.79
Gliomahsa052146.66
Prostate cancerhsa052156.11
Neurotrophin signaling pathwayhsa047225.78
Central carbon metabolism in cancerhsa052306.7
Herpes simplex infectionhsa051685.08
Epstein-Barr virus infectionhsa051694.97
Apoptosishsa042106.23
HTLV-I infectionhsa051664.59
Hepatitis Chsa051605.68
Hepatitis Bhsa051615.52
Measleshsa051625.6
Proteoglycans in cancerhsa052055.02
Cell cyclehsa041105.68
MicroRNAs in cancerhsa052065.38
Pathways in cancerhsa052003.98
Viral carcinogenesishsa052035.08
p53 signaling pathwayhsa041156.56
Non-small cell lung cancerhsa052236.88
Small cell lung cancerhsa052226.17
Chronic myeloid leukemiahsa052206.48
Thyroid hormone signaling pathwayhsa049195.82
PI3K-Akt signaling pathwayhsa041514.21
Wnt signaling pathwayhsa043105.49
Transcriptional misregulation in cancerhsa052025.21
Amyotrophic lateral sclerosis (ALS)hsa050147.01
Huntington's diseasehsa050165.17
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Oncogene Induced SenescenceR-HSA-25595858.03
Formation of Senescence-Associated Heterochromatin Foci (SAHF)R-HSA-25595848.98
DNA Damage/Telomere Stress Induced SenescenceR-HSA-25595867.15
Oxidative Stress Induced SenescenceR-HSA-25595806.51
Activation of PUMA and translocation to mitochondriaR-HSA-13991510.98
Transcriptional Regulation by TP53R-HSA-37009896.73
Signaling by NOTCHR-HSA-1571186.2
Programmed Cell DeathR-HSA-53578015.65
Cell CycleR-HSA-16401703.89
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.88
p53-Dependent G1 DNA Damage ResponseR-HSA-695637.15
Cellular SenescenceR-HSA-25595835.7
Generic Transcription PathwayR-HSA-2124363.86
Gene ExpressionR-HSA-741602.72
Cellular responses to stressR-HSA-22627524.56
Cell Cycle CheckpointsR-HSA-696205.64
Transcriptional activation of p53 responsive genes R-HSA-6956011.98
Stabilization of p53R-HSA-695417.28
p53-Dependent G1/S DNA damage checkpointR-HSA-695807.15
TP53 Regulates Metabolic GenesR-HSA-56288976.73
Transcriptional activation of cell cycle inhibitor p21 R-HSA-6989511.98
Activation of NOXA and translocation to mitochondriaR-HSA-11144810.98
Activation of BH3-only proteinsR-HSA-1144528.34
Pre-NOTCH Expression and ProcessingR-HSA-19124227.49
Autodegradation of the E3 ubiquitin ligase COP1R-HSA-3494257.31
Pre-NOTCH Transcription and TranslationR-HSA-19124088.12
G1/S DNA Damage CheckpointsR-HSA-696157.08
ApoptosisR-HSA-1095815.68
Intrinsic Pathway for ApoptosisR-HSA-1096067.73
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
ubiquitin-like protein ligase bindingGO:00443894.15
purine ribonucleoside triphosphate bindingGO:00356392.22
cation bindingGO:00431691.4
enzyme bindingGO:00198992.27
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
nucleotide bindingGO:00001661.96
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
transition metal ion bindingGO:00469142.48
transcription regulatory region DNA bindingGO:00442123.03
chaperone bindingGO:00510875.34
receptor tyrosine kinase bindingGO:00309715.77
ion bindingGO:00431671.36
identical protein bindingGO:00428022.63
purine nucleoside bindingGO:00018832.22
protease bindingGO:00020205.08
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
double-stranded DNA bindingGO:00036903.09
copper ion bindingGO:00055075.71
protein tyrosine kinase bindingGO:19907825.7
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
RNA polymerase II transcription factor bindingGO:00010855.08
protein heterodimerization activityGO:00469823.64
transcription factor bindingGO:00081343.46
regulatory region nucleic acid bindingGO:00010673.03
histone acetyltransferase bindingGO:00350356.41
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
protein phosphatase bindingGO:00199034.93
ubiquitin protein ligase bindingGO:00316254.17
core promoter bindingGO:00010474.71
core promoter sequence-specific DNA bindingGO:00010465.12
receptor bindingGO:00051022.43
protein self-associationGO:00436215.93
protein phosphatase 2A bindingGO:00517216.41
small molecule bindingGO:00360941.89
metal ion bindingGO:00468721.41
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
protein N-terminus bindingGO:00474855.11
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
nucleic acid binding transcription factor activityGO:00010712.65
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012283.98
purine ribonucleoside bindingGO:00325502.22
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
phosphatase bindingGO:00199024.63
adenyl ribonucleotide bindingGO:00325592.41
ATP bindingGO:00055242.43
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
purine ribonucleotide bindingGO:00325552.2
protein dimerization activityGO:00469832.72
chromatin bindingGO:00036823.64
p53 bindingGO:00020395.53
damaged DNA bindingGO:00036845.58
ribonucleotide bindingGO:00325532.19
zinc ion bindingGO:00082702.66