Disease ID | Disease name | Source of annotation with PROC | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS188050 | THROMBOPHILIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 13 | HRG, SERPIND1, F5, MTHFR, SERPINC1, THBD, F2, PROS1, PLAT, F9, HABP2, F13A1, PROC |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Complement and coagulation cascades | hsa04610 | 6.58 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Gamma-carboxylation of protein precursors | R-HSA-159740 | 9.81 |
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | R-HSA-159763 | 9.98 |
Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 7.7 |
Gamma carboxylation, hypusine formation and arylsulfatase activation | R-HSA-163841 | 7.81 |
Metabolism of proteins | R-HSA-392499 | 3.41 |
Cell surface interactions at the vascular wall | R-HSA-202733 | 6.32 |
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | R-HSA-159854 | 9.52 |
Removal of aminoterminal propeptides from gamma-carboxylated proteins | R-HSA-159782 | 9.81 |
Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 8.52 |
Post-translational protein modification | R-HSA-597592 | 4.54 |
Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.52 |
Hemostasis | R-HSA-109582 | 3.98 |
GO term | GO ID | GO IC |
---|---|---|
hydrolase activity | GO:0016787 | 1.9 |
endopeptidase activity | GO:0004175 | 3.63 |
serine-type endopeptidase activity | GO:0004252 | 4.4 |
serine hydrolase activity | GO:0017171 | 4.26 |
metal ion binding | GO:0046872 | 1.41 |
cation binding | GO:0043169 | 1.4 |
ion binding | GO:0043167 | 1.36 |
catalytic activity | GO:0003824 | 1.05 |
peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
peptidase activity | GO:0008233 | 3.23 |
serine-type peptidase activity | GO:0008236 | 4.27 |
calcium ion binding | GO:0005509 | 3.17 |