Disease table of THROMBOPHILIA OMIM ID: PS188050

Gene-disease associations table

GeneAssociated with THROMBOPHILIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
F2ClinVar, OMIMHGNC link11p11.24613679, PS188050, 614390, 601367
F5ClinVar, OMIM, HUMSAVARHGNC link1q24.25227400, PS188050, 614389, 601367, 600880
SERPINC1ClinVar, OMIM, HUMSAVARHGNC link1q25.12PS191100, PS188050
MTHFROMIMHGNC link1p36.225181500, PS188050, 606764, 236250, 601634
F9ClinVar, OMIM, HUMSAVARHGNC linkXq27.13PS188050, 306900, 122700
PROS1ClinVar, OMIM, HUMSAVARHGNC link3q11.11PS188050
PLATOMIMHGNC link8p11.211PS188050
HABP2OMIMHGNC link10q25.32PS188550, PS188050
F13A1OMIMHGNC link6p25.13608446, 613225, PS188050
HRGClinVar, OMIM, HUMSAVARHGNC link3q27.31PS188050
PROCClinVar, OMIM, HUMSAVARHGNC link2q14.31PS188050
THBDClinVar, OMIM, HUMSAVARHGNC link20p11.212PS235400, PS188050
SERPIND1ClinVar, OMIM, HUMSAVARHGNC link22q11.211PS188050

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1q22SERPINC1, F5
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2SERPINC1, F5
3q2HRG, PROS1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
13SERPINC1, MTHFR, F5
32HRG, PROS1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
CEBPANO50FN1, PRL, CXCR2, VLDLR, SLC2A4, TLR9, S100A9, CSF3R, MSR1, CSF1, AFP, ICAM1, SFTPD, ITGAX, INSR, HAMP, ELANE, STAR, SOCS3, DEFA1, CSF2RA, ID1, CYP3A4, SAA1, HOMER3, IGF1, GAPDH, PCK1, SLC10A1, CD163, SPP1, IL10, DEFA3, PCK2, F9, MAD1L1, SERPINC1, CDK2, BCL2, IL3, HSPA4, ALB, IGF2, IL5, IL6, HSD17B11, CRMP1, MYC, LEP, PRTN32F9, SERPINC1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12PLAT, THBD
RXRANO17IL2RA, HSD17B2, SERPINC1, ABCC3, IL2RG, CPT1B, ABCB11, THBD, IL2RB, CGB, GNRH2, NOL7, HNF1A, CXCR5, ABCA1, CYP3A4, HNF4A2SERPINC1, THBD
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SERPINC1YES7CEBPA, THRA, NR2F1, FOXA2, HNF4A, RXRA, FOXA10
MTHFRYES1NFE2L20
F9YES1CEBPA0
PLATYES8SP1, CREM, NF1, CREB1, JUN, ATF2, SP3, JUND0
F13A1YES2GATA1, ETS10
PROCYES1ONECUT10
THBDYES11SP1, RARB, EP300, KLF4, RARA, KLF2, RELA, PARP1, RXRA, NFKB1, RARG0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
F2F5Yes1F5
F2PROS1No1F5
F2PLATYes3FGA, FN1, SERPINE1
F2F13A1No2FGA, FN1
F2HRGNo2FGA, FN1
F2THBDYes0
F2SERPIND1Yes0
F5PROS1Yes1F5
F5PLATNo4CALR, F10, F2, POT1
F5THBDNo1F2
F5SERPIND1No1F2
F9PLATNo1LRP1
PLATF13A1No2FGA, FN1
PLATHRGNo2FGA, FN1
PLATPROCNo1SERPINA5
PLATTHBDNo1F2
PLATSERPIND1No1F2
F13A1HRGNo2FGA, FN1
F13A1PROCNo1TK1
PROCTHBDNo1PF4
THBDSERPIND1No1F2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
F2F5Yesactivation, binding11FN1, VWF, PROC, F13A1, F3, IGF2, F10, PROS1, SERPINE1, A2M, IGF1
F2SERPINC1Yesbinding7FGA, PROC, FGG, F11, F10, F9, FGB
F2F9Yesactivation, binding10GP5, F3, SERPINC1, GP1BA, GP9, F11, GP1BB, F10, GGCX, FURIN
F2PROS1Yesactivation, binding13FN1, IGF1, SERPINA5, SERPINE1, F13A1, IGF2, F10, VWF, A2M, GGCX, FURIN, F5, PROC
F2PLATYesactivation, binding2FGA, SERPINE1
F2HABP2No-1SERPINE1
F2F13A1Yesactivation, binding12FGA, FN1, SERPINE1, F13B, FGG, PROS1, IGF2, IGF1, A2M, F5, VWF, FGB
F2HRGNo-12FGA, FN1, VWF, SERPINE1, THBS1, PLAU, F13A1, IGF2, PROS1, IGF1, A2M, F5
F2PROCYesactivation, binding8SERPINA5, SERPINC1, PROS1, SERPINE1, A2M, GGCX, FURIN, F5
F2SERPIND1Yesbinding0
F5SERPINC1No-4PLG, F2, PROC, F10
F5F9No-5F10, F7, F2, F3, APP
F5PROS1Yesactivation, binding39PF4, FN1, LEFTY2, FIGF, F10, SERPINE1, A2M, KNG1, ACTN4, SRGN, ACTN1, PROC, SPARC, CLU, ALDOA, APP, TGFB1, F2, PPBP, MMRN1, TGFB2, PLG, VWF, F13A1, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, ALB, IGF2, IGF1, EGF, VEGFC, HRG, SERPINF2
F5PLATNo-3PLG, F2, SERPINE1
F5HABP2No-1SERPINE1
F5F13A1Yesreaction, binding37PF4, FN1, LEFTY2, FIGF, ALB, SERPINE1, A2M, KNG1, ACTN4, SRGN, ACTN1, SPARC, PROS1, CLU, ALDOA, APP, TGFB1, F2, PPBP, MMRN1, TGFB2, PLG, VWF, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, HRG, SERPINF2
F5HRGYesreaction, binding36PF4, FN1, LEFTY2, FIGF, ALB, SERPINE1, A2M, KNG1, ACTN4, SRGN, ACTN1, SPARC, PROS1, CLU, ALDOA, APP, TGFB1, PPBP, MMRN1, TGFB2, PLG, VWF, F13A1, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, SERPINF2
F5PROCYesactivation, binding, catalysis5PF4, A2M, F2, PROS1, SERPINE1
F5SERPIND1No-1F2
SERPINC1F9Yesbinding3F2, F11, F10
SERPINC1PROS1No-5F2, IL6, PLG, PROC, F10
SERPINC1PLATNo-3FGA, PLG, F2
SERPINC1F13A1No-5FGA, PLG, FGG, F2, FGB
SERPINC1HRGNo-2FGA, PLG
SERPINC1PROCYesactivation, binding1F2
SERPINC1SERPIND1No-1F2
F9PROS1No-5F10, FURIN, F2, APP, GGCX
F9PLATNo-1F2
F9F13A1No-2F2, APP
F9HRGNo-1APP
F9PROCNo-4F2, FURIN, GGCX, SERPINC1
F9SERPIND1No-1F2
PROS1PLATNo-3PLG, F2, SERPINE1
PROS1HABP2No-1SERPINE1
PROS1F13A1Yesreaction, binding37PF4, FN1, LEFTY2, FIGF, ALB, SERPINE1, A2M, KNG1, ACTN4, SRGN, ACTN1, SPARC, CLU, ALDOA, APP, TGFB1, F5, F2, PPBP, MMRN1, TGFB2, PLG, VWF, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, HRG, SERPINF2
PROS1HRGYesreaction, binding36PF4, FN1, LEFTY2, FIGF, ALB, SERPINE1, A2M, KNG1, ACTN4, SRGN, ACTN1, SPARC, CLU, ALDOA, APP, TGFB1, F5, PPBP, MMRN1, TGFB2, PLG, VWF, F13A1, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, SERPINF2
PROS1PROCYesactivation, binding8PF4, SERPINA5, F2, SERPINE1, A2M, F5, FURIN, GGCX
PROS1SERPIND1No-1F2
PLATHABP2No-1SERPINE1
PLATF13A1No-4FGA, PLG, F2, SERPINE1
PLATHRGNo-3FGA, PLG, SERPINE1
PLATPROCNo-3ITGAM, F2, SERPINE1
PLATSERPIND1No-1F2
HABP2F13A1No-1SERPINE1
HABP2HRGNo-1SERPINE1
HABP2PROCNo-1SERPINE1
F13A1HRGYesreaction, binding37PF4, FN1, LEFTY2, FIGF, ALB, SERPINE1, A2M, KNG1, ACTN4, SRGN, FGA, ACTN1, SPARC, PROS1, CLU, ALDOA, APP, TGFB1, F5, PPBP, MMRN1, TGFB2, PLG, VWF, SERPINA1, GAS6, TIMP1, VEGFA, VEGFB, ACTN2, TMSB4X, TGFB3, IGF2, IGF1, EGF, VEGFC, SERPINF2
F13A1PROCNo-6PF4, F2, PROS1, SERPINE1, A2M, F5
F13A1SERPIND1No-1F2
HRGPROCNo-5A2M, PF4, F5, PROS1, SERPINE1
PROCSERPIND1No-1F2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
F2F5Yes2F2, F5
F2SERPINC1Yes2F2, SERPINC1
F2F9No1SERPINC1
F2PROCYes2F2, PROC
F2THBDYes2F2, THBD
F2SERPIND1Yes2F2, SERPIND1
F5SERPINC1No1F2
F5PROCNo1F2
F5THBDNo1F2
F5SERPIND1No1F2
SERPINC1F9Yes2F9, SERPINC1
SERPINC1PROCNo1F2
SERPINC1THBDNo1F2
SERPINC1SERPIND1No1F2
PROCTHBDNo1F2
PROCSERPIND1No1F2
THBDSERPIND1No1F2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Complement and coagulation cascadeshsa046106.5810PROC, SERPINC1, F2, F13A1, PROS1, THBD, SERPIND1, PLAT, F5, F9

NET-GE enrichment

Term New enriched termICP valueGenes
Organismal SystemsNEW1.330.013PROC, SERPINC1, F2, F13A1, PROS1, THBD, SERPIND1, PLAT, F5, F9
Complement and coagulation cascades (hsa04610) -6.580.0PROC, SERPINC1, F2, F13A1, PROS1, THBD, SERPIND1, PLAT, F5, F9
Immune systemNEW2.920.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
HemostasisR-HSA-1095823.9811PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.79PROC, SERPINC1, F2, F13A1, PROS1, THBD, SERPIND1, F5, F9
Common Pathway of Fibrin Clot FormationR-HSA-1408758.528PROC, SERPINC1, F2, F13A1, THBD, PROS1, SERPIND1, F5
Platelet activation, signaling and aggregationR-HSA-760025.155F2, F5, F13A1, HRG, PROS1
Intrinsic Pathway of Fibrin Clot FormationR-HSA-1408378.525SERPIND1, F9, F2, PROC, SERPINC1
Gamma-carboxylation of protein precursorsR-HSA-1597409.814F9, F2, PROS1, PROC
Platelet degranulation R-HSA-1146086.684HRG, F13A1, F5, PROS1
Gamma carboxylation, hypusine formation and arylsulfatase activationR-HSA-1638417.814F9, F2, PROS1, PROC
Response to elevated platelet cytosolic Ca2+R-HSA-760056.594HRG, F13A1, F5, PROS1
Metabolism of proteinsR-HSA-3924993.414F9, F2, PROC, PROS1
Cell surface interactions at the vascular wallR-HSA-2027336.324F2, THBD, PROC, PROS1
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsR-HSA-1598549.524F2, F9, PROC, PROS1
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-1597829.814F2, F9, PROC, PROS1
Post-translational protein modificationR-HSA-5975924.544F2, F9, PROC, PROS1
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusR-HSA-1597639.984F2, PROS1, PROC, F9
Dissolution of Fibrin ClotR-HSA-752059.282HRG, PLAT
Signal TransductionR-HSA-1625821.782F2, PLAT

NET-GE enrichment

Term New enriched termICP valueGenes
Gamma-carboxylation of protein precursors (R-HSA-159740) -9.810.0F2, F5, PROS1, PROC, F9
Dissolution of Fibrin Clot (R-HSA-75205) -9.280.006F2, HRG, PLAT
Cell surface interactions at the vascular wall (R-HSA-202733) -6.320.0F2, F5, PROC, THBD, PROS1
Platelet degranulation (R-HSA-114608) -6.680.0HRG, F5, F13A1, F2, PROS1
Platelet activation, signaling and aggregation (R-HSA-76002) -5.150.034F2, F5, F13A1, HRG, PROS1
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841) -7.810.0F2, F5, PROS1, PROC, F9
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005) -6.590.0F2, F5, F13A1, HRG, PROS1
Hemostasis (R-HSA-109582) -3.980.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (R-HSA-159854) -9.520.0F2, F5, PROC, PROS1, F9
Removal of aminoterminal propeptides from gamma-carboxylated proteins (R-HSA-159782) -9.810.0F9, F5, F2, PROC, PROS1
Intrinsic Pathway of Fibrin Clot Formation (R-HSA-140837) -8.520.0SERPINC1, PROC, F2, SERPIND1, F5, F9
Common Pathway of Fibrin Clot Formation (R-HSA-140875) -8.520.0PROC, SERPINC1, F2, F13A1, THBD, PROS1, SERPIND1, F5
Post-translational protein modification (R-HSA-597592) -4.540.049F9, F2, PROC, PROS1
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877) -7.70.0PROC, SERPINC1, F2, F13A1, PROS1, THBD, SERPIND1, F5, F9
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus (R-HSA-159763) -9.980.0F9, F5, F2, PROS1, PROC
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1813SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, HABP2, PLAT, SERPIND1, F5, F9, PROC
cation binding (GO:0043169) 1.49PROC, F2, F13A1, PROS1, HRG, THBD, HABP2, F5, F9
metal ion binding (GO:0046872) 1.419PROC, F2, F13A1, PROS1, HRG, THBD, HABP2, F5, F9
protein binding (GO:0005515) 0.469SERPINC1, MTHFR, F2, PROS1, HRG, THBD, PLAT, F5, PROC
ion binding (GO:0043167) 1.369PROC, F2, F13A1, PROS1, HRG, THBD, HABP2, F5, F9
catalytic activity (GO:0003824) 1.057PROC, MTHFR, F2, F13A1, HABP2, F9, PLAT
calcium ion binding (GO:0005509) 3.176PROC, F2, PROS1, THBD, HABP2, F9
serine-type endopeptidase activity (GO:0004252) 4.45F9, HABP2, F2, PROC, PLAT
endopeptidase activity (GO:0004175) 3.635F9, HABP2, F2, PROC, PLAT
serine hydrolase activity (GO:0017171) 4.265F9, HABP2, F2, PROC, PLAT
carbohydrate derivative binding (GO:0097367) 2.035SERPIND1, HRG, HABP2, SERPINC1, PLAT
hydrolase activity (GO:0016787) 1.95F9, HABP2, F2, PROC, PLAT
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.265F9, HABP2, F2, PROC, PLAT
peptidase activity (GO:0008233) 3.235F9, HABP2, F2, PROC, PLAT
serine-type peptidase activity (GO:0008236) 4.275F9, HABP2, F2, PROC, PLAT
peptidase inhibitor activity (GO:0030414) 4.554HRG, SERPIND1, PROS1, SERPINC1
endopeptidase regulator activity (GO:0061135) 4.574HRG, SERPIND1, PROS1, SERPINC1
peptidase regulator activity (GO:0061134) 4.374HRG, SERPIND1, PROS1, SERPINC1
glycosaminoglycan binding (GO:0005539) 4.424HRG, HABP2, SERPIND1, SERPINC1
endopeptidase inhibitor activity (GO:0004866) 4.64HRG, SERPIND1, PROS1, SERPINC1
enzyme inhibitor activity (GO:0004857) 3.784HRG, SERPIND1, PROS1, SERPINC1
molecular function regulator (GO:0098772) 2.514HRG, SERPIND1, PROS1, SERPINC1
enzyme regulator activity (GO:0030234) 2.854HRG, SERPIND1, PROS1, SERPINC1
sulfur compound binding (GO:1901681) 4.323HRG, SERPINC1, SERPIND1
macromolecular complex binding (GO:0044877) 2.613HRG, PROS1, MTHFR
serine-type endopeptidase inhibitor activity (GO:0004867) 5.163HRG, SERPINC1, SERPIND1
protein complex binding (GO:0032403) 3.093HRG, PROS1, MTHFR
receptor binding (GO:0005102) 2.433HRG, F2, PLAT
heparin binding (GO:0008201) 4.683HRG, SERPINC1, SERPIND1
glycoprotein binding (GO:0001948) 5.112HRG, PLAT
signaling receptor activity (GO:0038023) 2.492F2, THBD
transition metal ion binding (GO:0046914) 2.482HRG, F5
organic cyclic compound binding (GO:0097159) 1.052HRG, MTHFR
molecular transducer activity (GO:0060089) 2.322F2, THBD
receptor activity (GO:0004872) 2.322F2, THBD
signal transducer activity (GO:0004871) 2.282F2, THBD
heterocyclic compound binding (GO:1901363) 1.062HRG, MTHFR

NET-GE enrichment

Term New enriched termICP valueGenes
sulfur compound binding (GO:1901681) -4.320.03SERPINC1, PROC, F2, THBD, SERPIND1, PLAT, HRG
serine-type endopeptidase activity (GO:0004252) -4.40.0PROC, F2, F13A1, HABP2, PLAT, F5, F9
endopeptidase activity (GO:0004175) -3.630.0PROC, SERPINC1, F2, F13A1, HABP2, PLAT, F5, F9
peptidase inhibitor activity (GO:0030414) -4.550.0SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
peptidase activity (GO:0008233) -3.230.007PROC, SERPINC1, F2, F13A1, PROS1, HABP2, PLAT, F5, F9
serine hydrolase activity (GO:0017171) -4.260.0PROC, F2, F13A1, HABP2, PLAT, F5, F9
carbohydrate derivative binding (GO:0097367) -2.030.016PROC, SERPINC1, F2, F13A1, THBD, HRG, SERPIND1, HABP2, PLAT, F5, F9
endopeptidase regulator activity (GO:0061135) -4.570.0SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
peptidase regulator activity (GO:0061134) -4.370.0SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
ion binding (GO:0043167) -1.360.042SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, SERPIND1, F5, F9, PROC
glycosaminoglycan binding (GO:0005539) -4.420.001PROC, SERPINC1, F2, THBD, SERPIND1, HABP2, PLAT, HRG
peptidase activity, acting on L-amino acid peptides (GO:0070011) -3.260.006PROC, SERPINC1, F2, F13A1, PROS1, HABP2, PLAT, F5, F9
calcium ion binding (GO:0005509) -3.170.005PROC, F2, F13A1, PROS1, THBD, PLAT, F5, F9
endopeptidase inhibitor activity (GO:0004866) -4.60.0SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
serine-type endopeptidase inhibitor activity (GO:0004867) -5.160.0SERPIND1, F2, HRG, SERPINC1, PLAT
enzyme inhibitor activity (GO:0004857) -3.780.006SERPINC1, F2, F13A1, PROS1, HRG, SERPIND1, PLAT, F5
heparin binding (GO:0008201) -4.680.0SERPINC1, PROC, F2, THBD, SERPIND1, PLAT, HRG
serine-type peptidase activity (GO:0008236) -4.270.0PROC, F2, F13A1, HABP2, PLAT, F5, F9
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
multicellular organismal process (GO:0032501) 1.4512SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, SERPIND1, F5, F9, PROC
biological regulation (GO:0065007) 0.3912SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, SERPIND1, F5, F9, PROC
single-organism process (GO:0044699) 0.4812SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, SERPIND1, F5, F9, PROC
cellular process (GO:0009987) 0.2611PROC, MTHFR, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
hemostasis (GO:0007599) 4.511PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
regulation of body fluid levels (GO:0050878) 3.7611PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
single-multicellular organism process (GO:0044707) 1.7811PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
blood coagulation (GO:0007596) 4.5211PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
coagulation (GO:0050817) 4.5111PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
regulation of biological quality (GO:0065008) 1.6811PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
response to stimulus (GO:0050896) 1.229SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, F9
single-organism cellular process (GO:0044763) 0.659PROC, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, F5
regulation of biological process (GO:0050789) 0.459SERPINC1, MTHFR, F2, THBD, PROS1, SERPIND1, PLAT, HRG, PROC
metabolic process (GO:0008152) 0.589PROC, MTHFR, F2, F13A1, PROS1, SERPIND1, HABP2, PLAT, F9
regulation of cellular process (GO:0050794) 0.59SERPINC1, MTHFR, F2, PROS1, THBD, SERPIND1, PLAT, HRG, PROC
negative regulation of biological process (GO:0048519) 1.338SERPINC1, PROC, F2, THBD, PROS1, SERPIND1, PLAT, HRG
primary metabolic process (GO:0044238) 0.698PROC, MTHFR, F2, F13A1, PROS1, HABP2, PLAT, F9
cellular metabolic process (GO:0044237) 0.698PROC, MTHFR, F2, F13A1, PROS1, SERPIND1, PLAT, F9
negative regulation of cellular process (GO:0048523) 1.418SERPINC1, PROC, F2, PROS1, THBD, SERPIND1, PLAT, HRG
organic substance metabolic process (GO:0071704) 0.638PROC, MTHFR, F2, F13A1, PROS1, HABP2, PLAT, F9
negative regulation of response to external stimulus (GO:0032102) 4.187SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
regulation of primary metabolic process (GO:0080090) 1.087SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
regulation of metabolic process (GO:0019222) 1.027SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
regulation of response to external stimulus (GO:0032101) 3.067SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
negative regulation of response to stimulus (GO:0048585) 2.527SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
regulation of response to stimulus (GO:0048583) 1.547SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
regulation of wound healing (GO:0061041) 4.887SERPINC1, PROC, F2, PROS1, THBD, PLAT, HRG
regulation of protein metabolic process (GO:0051246) 1.937SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
regulation of hemostasis (GO:1900046) 5.267SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
regulation of response to wounding (GO:1903034) 4.747SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
regulation of macromolecule metabolic process (GO:0060255) 1.087SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
regulation of cellular metabolic process (GO:0031323) 1.077SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
transport (GO:0006810) 1.517PROC, F2, F13A1, PROS1, F5, HRG, F9
regulation of multicellular organismal process (GO:0051239) 1.877SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
establishment of localization (GO:0051234) 1.487PROC, F2, F13A1, PROS1, F5, HRG, F9
regulation of coagulation (GO:0050818) 5.227SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
localization (GO:0051179) 1.47PROC, F2, F13A1, PROS1, F5, HRG, F9
locomotion (GO:0040011) 2.917PROC, F2, PROS1, THBD, SERPIND1, PLAT, HRG
regulation of cellular protein metabolic process (GO:0032268) 1.997SERPINC1, MTHFR, F2, PROS1, SERPIND1, PLAT, HRG
vesicle-mediated transport (GO:0016192) 2.727PROC, F2, F13A1, PROS1, F5, HRG, F9
protein metabolic process (GO:0019538) 1.457PROC, F2, F13A1, PROS1, HABP2, F9, PLAT
regulation of response to stress (GO:0080134) 2.537SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
macromolecule metabolic process (GO:0043170) 0.837PROC, F2, F13A1, PROS1, HABP2, F9, PLAT
regulation of blood coagulation (GO:0030193) 5.267SERPINC1, PROC, F2, THBD, PROS1, PLAT, HRG
cellular protein metabolic process (GO:0044267) 1.636PROC, F2, F13A1, PROS1, F9, PLAT
negative regulation of protein metabolic process (GO:0051248) 2.826SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
protein modification process (GO:0036211) 1.796PROC, F2, F13A1, PROS1, F9, PLAT
negative regulation of metabolic process (GO:0009892) 1.936SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
cellular macromolecule metabolic process (GO:0044260) 0.936PROC, F2, F13A1, PROS1, F9, PLAT
response to external stimulus (GO:0009605) 2.556SERPINC1, MTHFR, F2, THBD, PROS1, HRG
negative regulation of multicellular organismal process (GO:0051241) 2.846PROC, F2, PROS1, THBD, PLAT, HRG
negative regulation of cellular metabolic process (GO:0031324) 2.016SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
negative regulation of cellular protein metabolic process (GO:0032269) 2.886SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
cellular protein modification process (GO:0006464) 1.796PROC, F2, F13A1, PROS1, F9, PLAT
negative regulation of coagulation (GO:0050819) 5.826PROC, F2, THBD, PROS1, PLAT, HRG
macromolecule modification (GO:0043412) 1.736PROC, F2, F13A1, PROS1, F9, PLAT
negative regulation of hemostasis (GO:1900047) 5.886PROC, F2, PROS1, THBD, PLAT, HRG
regulation of proteolysis (GO:0030162) 3.26SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
negative regulation of wound healing (GO:0061045) 5.656PROC, F2, PROS1, THBD, PLAT, HRG
proteolysis (GO:0006508) 2.736PROC, F2, PROS1, HABP2, F9, PLAT
negative regulation of macromolecule metabolic process (GO:0010605) 2.016SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
negative regulation of proteolysis (GO:0045861) 3.986SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
negative regulation of response to wounding (GO:1903035) 5.546PROC, F2, PROS1, THBD, PLAT, HRG
negative regulation of blood coagulation (GO:0030195) 5.886PROC, F2, PROS1, THBD, PLAT, HRG
organonitrogen compound metabolic process (GO:1901564) 2.325F2, F9, PROS1, MTHFR, PROC
protein maturation (GO:0051604) 4.485PLAT, F2, PROC, PROS1, F9
intracellular transport (GO:0046907) 2.675F2, F5, PROS1, PROC, F9
cell motility (GO:0048870) 3.025PLAT, F2, THBD, PROS1, PROC
Golgi vesicle transport (GO:0048193) 4.075F2, F5, PROS1, PROC, F9
cellular nitrogen compound metabolic process (GO:0034641) 1.225F2, F9, PROS1, MTHFR, PROC
movement of cell or subcellular component (GO:0006928) 2.615PLAT, F2, THBD, PROS1, PROC
protein processing (GO:0016485) 4.625PLAT, F9, F2, PROS1, PROC
response to stress (GO:0006950) 1.85F2, F13A1, HRG, MTHFR, PLAT
nitrogen compound metabolic process (GO:0006807) 1.135F9, F2, PROC, MTHFR, PROS1
cellular amide metabolic process (GO:0043603) 3.235F9, PROS1, F2, MTHFR, PROC
establishment of localization in cell (GO:0051649) 2.475F2, F5, PROS1, PROC, F9
positive regulation of biological process (GO:0048518) 1.25F2, HRG, PROC, THBD, PROS1
ER to Golgi vesicle-mediated transport (GO:0006888) 4.75F2, F5, F9, PROS1, PROC
cell migration (GO:0016477) 3.125PLAT, F2, THBD, PROS1, PROC
cellular localization (GO:0051641) 2.325F9, F5, F2, PROC, PROS1
regulation of cellular component organization (GO:0051128) 2.014F2, HRG, PROS1, MTHFR
leukocyte migration (GO:0050900) 4.194F2, THBD, PROC, PROS1
negative regulation of catalytic activity (GO:0043086) 3.04HRG, SERPIND1, PROS1, SERPINC1
negative regulation of hydrolase activity (GO:0051346) 3.744HRG, SERPIND1, PROS1, SERPINC1
protein carboxylation (GO:0018214) 7.334F9, F2, PROC, PROS1
exocytosis (GO:0006887) 4.114HRG, F13A1, F5, PROS1
peptidyl-amino acid modification (GO:0018193) 2.984F2, PROC, PROS1, F9
regulated exocytosis (GO:0045055) 4.444HRG, F13A1, F5, PROS1
negative regulation of peptidase activity (GO:0010466) 4.224HRG, SERPIND1, PROS1, SERPINC1
negative regulation of molecular function (GO:0044092) 2.744HRG, SERPIND1, PROS1, SERPINC1
regulation of molecular function (GO:0065009) 1.784HRG, SERPIND1, PROS1, SERPINC1
regulation of peptidase activity (GO:0052547) 3.754HRG, SERPIND1, PROS1, SERPINC1
regulation of endopeptidase activity (GO:0052548) 3.84HRG, SERPIND1, PROS1, SERPINC1
regulation of catalytic activity (GO:0050790) 1.974HRG, SERPIND1, PROS1, SERPINC1
fibrinolysis (GO:0042730) 6.684F2, HRG, PROS1, PLAT
signal peptide processing (GO:0006465) 6.514F9, F2, PROS1, PROC
single-organism transport (GO:0044765) 2.184HRG, F13A1, F5, PROS1
secretion by cell (GO:0032940) 3.594HRG, F13A1, F5, PROS1
negative regulation of endopeptidase activity (GO:0010951) 4.264HRG, SERPIND1, PROS1, SERPINC1
response to chemical (GO:0042221) 1.984SERPINC1, THBD, MTHFR, PROS1
single-organism localization (GO:1902578) 2.094HRG, F13A1, F5, PROS1
regulation of hydrolase activity (GO:0051336) 2.534HRG, SERPIND1, PROS1, SERPINC1
response to abiotic stimulus (GO:0009628) 2.84F2, THBD, MTHFR, PLAT
secretion (GO:0046903) 3.384HRG, F13A1, F5, PROS1
peptidyl-glutamic acid carboxylation (GO:0017187) 7.334F2, PROS1, PROC, F9
peptidyl-glutamic acid modification (GO:0018200) 6.334F2, PROC, PROS1, F9
immune system process (GO:0002376) 2.294F2, PROS1, PROC, THBD
peptide metabolic process (GO:0006518) 3.444F2, PROC, PROS1, F9
platelet degranulation (GO:0002576) 5.124HRG, F13A1, F5, PROS1
positive regulation of cellular process (GO:0048522) 1.34F2, HRG, PROS1, PROC
positive regulation of response to external stimulus (GO:0032103) 4.173HRG, F2, THBD
regulation of cell activation (GO:0050865) 3.533F2, HRG, THBD
positive regulation of response to stimulus (GO:0048584) 2.183F2, HRG, THBD
positive regulation of coagulation (GO:0050820) 6.513F2, HRG, THBD
signal transduction (GO:0007165) 1.283F2, PLAT, THBD
positive regulation of wound healing (GO:0090303) 5.883HRG, F2, THBD
regulation of defense response (GO:0031347) 3.113PROS1, PROC, SERPINC1
response to external biotic stimulus (GO:0043207) 3.133HRG, PROS1, THBD
positive regulation of multicellular organismal process (GO:0051240) 2.493F2, HRG, THBD
regulation of inflammatory response (GO:0050727) 4.033PROS1, PROC, SERPINC1
regulation of fibrinolysis (GO:0051917) 7.093F2, HRG, THBD
regulation of platelet activation (GO:0010543) 6.263F2, HRG, THBD
regulation of protein modification process (GO:0031399) 2.323F2, HRG, MTHFR
positive regulation of hemostasis (GO:1900048) 6.553HRG, F2, THBD
regulation of gene expression (GO:0010468) 1.373F2, HRG, PROS1
positive regulation of response to wounding (GO:1903036) 5.763F2, HRG, THBD
regulation of developmental process (GO:0050793) 2.13F2, HRG, PROC
cell activation (GO:0001775) 3.473F2, F5, HRG
regulation of localization (GO:0032879) 1.943HRG, F2, PROS1
response to organic substance (GO:0010033) 2.23THBD, MTHFR, PROS1
platelet activation (GO:0030168) 4.963F2, F5, HRG
response to oxygen-containing compound (GO:1901700) 2.573THBD, MTHFR, PROS1
response to biotic stimulus (GO:0009607) 3.093HRG, PROS1, THBD
regulation of multicellular organismal development (GO:2000026) 2.313F2, HRG, PROC
negative regulation of fibrinolysis (GO:0051918) 7.433HRG, F2, THBD
positive regulation of blood coagulation (GO:0030194) 6.553F2, HRG, THBD
developmental process (GO:0032502) 1.362F2, HRG
response to extracellular stimulus (GO:0009991) 3.712SERPINC1, MTHFR
regulation of phosphate metabolic process (GO:0019220) 2.352HRG, F2
regulation of organelle organization (GO:0033043) 2.722HRG, MTHFR
macromolecular complex subunit organization (GO:0043933) 2.142F5, MTHFR
regulation of transport (GO:0051049) 2.242F2, PROS1
blood coagulation, intrinsic pathway (GO:0007597) 6.842F9, F2
negative regulation of cell activation (GO:0050866) 4.672F2, THBD
response to wounding (GO:0009611) 4.392F2, F13A1
negative regulation of defense response (GO:0031348) 4.752SERPINC1, PROC
circulatory system process (GO:0003013) 4.382F5, MTHFR
regulation of phosphorus metabolic process (GO:0051174) 2.352HRG, F2
cellular component organization (GO:0016043) 1.242F5, MTHFR
cell surface receptor signaling pathway (GO:0007166) 2.092F2, PLAT
negative regulation of platelet activation (GO:0010544) 6.842F2, THBD
response to lipopolysaccharide (GO:0032496) 4.032PROS1, THBD
response to hypoxia (GO:0001666) 4.132PLAT, MTHFR
regulation of apoptotic process (GO:0042981) 2.52HRG, PROC
response to organic cyclic compound (GO:0014070) 3.072THBD, MTHFR
response to endogenous stimulus (GO:0009719) 2.792THBD, MTHFR
negative regulation of inflammatory response (GO:0050728) 5.112SERPINC1, PROC
regulation of cell communication (GO:0010646) 1.732F2, HRG
taxis (GO:0042330) 4.032HRG, SERPIND1
protein activation cascade (GO:0072376) 5.212F9, F2
regulation of signal transduction (GO:0009966) 1.842F2, HRG
response to lipid (GO:0033993) 3.112PROS1, THBD
regulation of growth (GO:0040008) 3.262HRG, F2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792F2, HRG
zymogen activation (GO:0031638) 6.332F9, PLAT
regulation of cell development (GO:0060284) 3.012F2, PROC
regulation of signaling (GO:0023051) 1.722F2, HRG
regulation of programmed cell death (GO:0043067) 2.492HRG, PROC
regulation of immune system process (GO:0002682) 2.52HRG, PROS1
cellular component organization or biogenesis (GO:0071840) 1.222F5, MTHFR
response to oxygen levels (GO:0070482) 4.022PLAT, MTHFR
response to nutrient (GO:0007584) 4.492SERPINC1, MTHFR
regulation of cell proliferation (GO:0042127) 2.412F2, HRG
negative regulation of developmental process (GO:0051093) 3.172HRG, F2
chemotaxis (GO:0006935) 4.042HRG, SERPIND1
positive regulation of transport (GO:0051050) 2.92F2, PROS1
blood circulation (GO:0008015) 5.972F5, MTHFR
system process (GO:0003008) 2.32F5, MTHFR
regulation of protein activation cascade (GO:2000257) 6.172SERPINC1, PROS1
single-organism developmental process (GO:0044767) 1.492F2, HRG
regulation of cell differentiation (GO:0045595) 2.422F2, PROC
regulation of cell growth (GO:0001558) 3.752F2, HRG
multi-organism process (GO:0051704) 2.652HRG, THBD
regulation of phosphorylation (GO:0042325) 2.52F2, HRG
defense response (GO:0006952) 2.782HRG, F2
regulation of immune response (GO:0050776) 2.982HRG, PROS1
response to decreased oxygen levels (GO:0036293) 4.092PLAT, MTHFR
response to organonitrogen compound (GO:0010243) 3.22THBD, MTHFR
regulation of cell death (GO:0010941) 2.432HRG, PROC
response to nutrient levels (GO:0031667) 3.772SERPINC1, MTHFR
response to molecule of bacterial origin (GO:0002237) 3.992PROS1, THBD
regulation of protein phosphorylation (GO:0001932) 2.572HRG, F2
positive regulation of cellular component organization (GO:0051130) 2.682HRG, PROS1
response to nitrogen compound (GO:1901698) 3.122THBD, MTHFR

NET-GE enrichment

Term New enriched termICP valueGenes
exocytosis (GO:0006887) -4.110.008PROC, F2, F13A1, PROS1, F5, HRG
hemostasis (GO:0007599) -4.50.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
regulation of response to external stimulus (GO:0032101) -3.060.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, PLAT, F5
blood coagulation, intrinsic pathway (GO:0007597) -6.840.034F9, F2
blood coagulation (GO:0007596) -4.520.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
positive regulation of coagulation (GO:0050820) -6.510.0HRG, F2, THBD
regulation of wound healing (GO:0061041) -4.880.0F5, PROC, SERPINC1, F2, PROS1, THBD, PLAT, HRG
negative regulation of hydrolase activity (GO:0051346) -3.740.044F5, SERPINC1, F2, PROS1, SERPIND1, PLAT, HRG
protein carboxylation (GO:0018214) -7.330.0F9, F5, F2, PROC, PROS1
negative regulation of multicellular organismal process (GO:0051241) -2.840.0PROC, F2, F13A1, THBD, HRG, PROS1, F5, PLAT
regulation of hemostasis (GO:1900046) -5.260.0F5, PROC, SERPINC1, F2, PROS1, THBD, PLAT, HRG
regulation of fibrinolysis (GO:0051917) -7.090.001F2, HRG, THBD
negative regulation of platelet activation (GO:0010544) -6.840.01F2, THBD
negative regulation of hemostasis (GO:1900047) -5.880.0PROC, F2, PROS1, THBD, PLAT, F5, HRG
regulation of platelet activation (GO:0010543) -6.260.019F2, HRG, THBD
proteolysis (GO:0006508) -2.730.005PROC, SERPINC1, F2, F13A1, PROS1, HABP2, PLAT, F5, F9
cell migration (GO:0016477) -3.120.032PLAT, F2, THBD, PROS1, PROC
positive regulation of hemostasis (GO:1900048) -6.550.0HRG, F2, THBD
negative regulation of fibrinolysis (GO:0051918) -7.430.0HRG, F2, THBD
multicellular organismal process (GO:0032501) -1.450.0SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, SERPIND1, F5, F9, PROC
regulation of body fluid levels (GO:0050878) -3.760.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
regulation of peptidase activity (GO:0052547) -3.750.005SERPINC1, F2, F13A1, PROS1, SERPIND1, PLAT, HRG
regulation of endopeptidase activity (GO:0052548) -3.80.044SERPINC1, F2, F13A1, PROS1, SERPIND1, PLAT, HRG
post-translational protein modification (GO:0043687) NEW6.170.005F2, F5, PROC, PROS1, F9
regulation of protein activation cascade (GO:2000257) -6.170.009F2, SERPINC1, PROS1
cell activation (GO:0001775) -3.470.015F2, F5, F13A1, HRG, PROS1
coagulation (GO:0050817) -4.510.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
regulation of proteolysis (GO:0030162) -3.20.0SERPINC1, F2, F13A1, PROS1, SERPIND1, PLAT, HRG
response to metal ion (GO:0010038) NEW3.910.011F2, F13A1, THBD, PLAT, F5, HRG
negative regulation of endopeptidase activity (GO:0010951) -4.260.008SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
regulation of coagulation (GO:0050818) -5.220.0PROC, SERPINC1, F2, THBD, HRG, PROS1, PLAT, F5
negative regulation of coagulation (GO:0050819) -5.820.0PROC, F2, THBD, HRG, PROS1, F5, PLAT
platelet activation (GO:0030168) -4.960.023F2, F5, F13A1, HRG, PROS1
platelet degranulation (GO:0002576) -5.120.0HRG, F5, F13A1, F2, PROS1
locomotion (GO:0040011) -2.910.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5
fibrinolysis (GO:0042730) -6.680.0F2, HRG, PROS1, PLAT
regulation of biological quality (GO:0065008) -1.680.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, SERPIND1, PLAT, F5, F9
single-multicellular organism process (GO:0044707) -1.780.0SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, SERPIND1, F5, F9, PROC
cell motility (GO:0048870) -3.020.049PLAT, F2, THBD, PROS1, PROC
regulation of response to wounding (GO:1903034) -4.740.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, PLAT, F5
regulation of response to stress (GO:0080134) -2.530.018PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, PLAT, F5
peptidyl-glutamic acid carboxylation (GO:0017187) -7.330.0F2, F5, PROS1, PROC, F9
peptidyl-glutamic acid modification (GO:0018200) -6.330.0F2, F5, PROC, PROS1, F9
leukocyte migration (GO:0050900) -4.190.007F2, F5, THBD, PROC, PROS1
regulation of blood coagulation (GO:0030193) -5.260.0PROC, SERPINC1, F2, THBD, HRG, PROS1, PLAT, F5
negative regulation of peptidase activity (GO:0010466) -4.220.006SERPINC1, F2, SERPIND1, PROS1, PLAT, HRG
negative regulation of blood coagulation (GO:0030195) -5.880.0PROC, F2, PROS1, THBD, PLAT, F5, HRG
positive regulation of blood coagulation (GO:0030194) -6.550.0HRG, F2, THBD
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
extracellular region part (GO:0044421) 1.5712PROC, SERPINC1, F2, F13A1, PROS1, HRG, THBD, HABP2, SERPIND1, PLAT, F5, F9
extracellular region (GO:0005576) 2.1811PROC, SERPINC1, F2, F13A1, PROS1, HRG, SERPIND1, HABP2, PLAT, F5, F9
cell part (GO:0044464) 0.1111SERPINC1, MTHFR, F2, F13A1, PROS1, HRG, THBD, PLAT, F5, F9, PROC
extracellular space (GO:0005615) 2.6310PROC, SERPINC1, F2, PROS1, THBD, HABP2, SERPIND1, PLAT, F5, F9
intracellular part (GO:0044424) 0.289PROC, MTHFR, F2, F13A1, PROS1, HRG, PLAT, F5, F9
cytoplasmic part (GO:0044444) 0.829PROC, MTHFR, F2, F13A1, PROS1, HRG, PLAT, F5, F9
membrane-bounded organelle (GO:0043227) 0.479PROC, SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
organelle (GO:0043226) 0.49PROC, SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
extracellular vesicle (GO:1903561) 1.898SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
extracellular organelle (GO:0043230) 1.898SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
vesicle (GO:0031982) 1.648SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
membrane-bounded vesicle (GO:0031988) 1.718SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
extracellular exosome (GO:0070062) 1.897SERPINC1, F2, PROS1, SERPIND1, PLAT, HRG, F9
organelle lumen (GO:0043233) 3.057PROC, F2, F13A1, PROS1, F5, HRG, F9
membrane (GO:0016020) 0.687SERPINC1, F2, PROS1, THBD, F5, HRG, F9
membrane-enclosed lumen (GO:0031974) 3.057PROC, F2, F13A1, PROS1, F5, HRG, F9
intracellular organelle part (GO:0044446) 0.817PROC, F2, F13A1, PROS1, F5, HRG, F9
intracellular organelle lumen (GO:0070013) 3.057PROC, F2, F13A1, PROS1, F5, HRG, F9
plasma membrane (GO:0005886) 1.397SERPINC1, F2, THBD, HRG, PROS1, F5, F9
organelle part (GO:0044422) 0.797PROC, F2, F13A1, PROS1, F5, HRG, F9
endoplasmic reticulum part (GO:0044432) 2.735F2, F5, PROC, PROS1, F9
Golgi apparatus part (GO:0044431) 3.05F9, F5, F2, PROC, PROS1
blood microparticle (GO:0072562) 4.885HRG, F13A1, F2, PROS1, SERPINC1
Golgi lumen (GO:0005796) 5.284F2, PROS1, PROC, F9
vesicle lumen (GO:0031983) 5.174HRG, F13A1, F5, PROS1
intracellular membrane-bounded organelle (GO:0043231) 0.64HRG, F5, PROC, PLAT
platelet alpha granule lumen (GO:0031093) 5.814HRG, F13A1, F5, PROS1
secretory granule lumen (GO:0034774) 5.384HRG, F13A1, F5, PROS1
endoplasmic reticulum lumen (GO:0005788) 4.54F9, F5, F2, PROC
cytoplasmic vesicle part (GO:0044433) 3.414HRG, F13A1, F5, PROS1
intracellular organelle (GO:0043229) 0.514HRG, F5, PROC, PLAT
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.194HRG, F13A1, F5, PROS1
cytoplasm (GO:0005737) 1.012PLAT, F13A1
organelle membrane (GO:0031090) 1.972F5, PROS1
secretory vesicle (GO:0099503) 4.02F5, PLAT
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122F5, PLAT
cytoplasmic vesicle (GO:0031410) 2.872F5, PLAT
integral component of membrane (GO:0016021) 1.142PROS1, THBD
extracellular matrix (GO:0031012) 3.812F2, PLAT
intracellular vesicle (GO:0097708) 2.862F5, PLAT
secretory granule (GO:0030141) 4.342F5, PLAT
membrane part (GO:0044425) 0.952PROS1, THBD
Golgi membrane (GO:0000139) 3.282F5, PROS1
cell surface (GO:0009986) 3.442PLAT, THBD
bounding membrane of organelle (GO:0098588) 2.392F5, PROS1
intrinsic component of membrane (GO:0031224) 1.132PROS1, THBD

NET-GE enrichment

Term New enriched termICP valueGenes
Golgi lumen (GO:0005796) -5.280.0SERPINC1, PROC, F2, PROS1, F5, F9
vesicle lumen (GO:0031983) -5.170.0F2, F5, F13A1, HRG, PROS1
vesicle (GO:0031982) -1.640.025SERPINC1, F2, PROS1, HRG, SERPIND1, PLAT, F5, F9
platelet alpha granule lumen (GO:0031093) -5.810.0HRG, F5, F13A1, F2, PROS1
organelle lumen (GO:0043233) -3.050.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, PLAT, F5, F9
extracellular space (GO:0005615) -2.630.001PROC, SERPINC1, F2, F13A1, PROS1, THBD, HABP2, SERPIND1, PLAT, F5
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) -5.190.0HRG, F5, F13A1, F2, PROS1
endoplasmic reticulum lumen (GO:0005788) -4.50.002F9, F5, F2, PROC, PLAT
cytoplasmic vesicle part (GO:0044433) -3.410.008PROC, F2, F13A1, PROS1, PLAT, F5, HRG
intracellular organelle lumen (GO:0070013) -3.050.009PROC, SERPINC1, F2, PROS1, PLAT, F5, F9
Golgi apparatus part (GO:0044431) -3.00.036PROC, SERPINC1, F2, PROS1, PLAT, F5, F9
extracellular region (GO:0005576) -2.180.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, SERPIND1, HABP2, PLAT, F5, F9
membrane-enclosed lumen (GO:0031974) -3.050.0PROC, SERPINC1, F2, F13A1, PROS1, HRG, PLAT, F5, F9
secretory granule lumen (GO:0034774) -5.380.0F2, HRG, F13A1, F5, PROS1
extracellular region part (GO:0044421) -1.570.0SERPINC1, F2, F13A1, PROS1, HRG, THBD, HABP2, SERPIND1, PLAT, F5, F9
blood microparticle (GO:0072562) -4.880.0SERPINC1, F2, F13A1, PROS1, HRG, PLAT, F5