| Disease ID | Disease name | Source of annotation with REN | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS162000 | HYPERURICEMIC NEPHROPATHY, FAMILIAL JUVENILE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 2 | UMOD, REN |
| 267430 | RENAL TUBULAR DYSGENESIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 4 | REN, AGT, ACE, AGTR1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Renin-angiotensin system | hsa04614 | 8.68 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 8.98 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| insulin-like growth factor receptor binding | GO:0005159 | 7.03 |
| aspartic-type peptidase activity | GO:0070001 | 6.1 |
| catalytic activity | GO:0003824 | 1.05 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| aspartic-type endopeptidase activity | GO:0004190 | 6.13 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| peptidase activity | GO:0008233 | 3.23 |
| receptor binding | GO:0005102 | 2.43 |