Disease table of RENAL TUBULAR DYSGENESIS OMIM ID: 267430

Gene-disease associations table

GeneAssociated with RENAL TUBULAR DYSGENESIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
AGTR1ClinVar, OMIM, HUMSAVARHGNC link3q242145500, 267430
AGTClinVar, OMIM, HUMSAVARHGNC link1q42.23PS189800, 267430, 145500
RENClinVar, OMIM, HUMSAVARHGNC link1q32.12PS162000, 267430
ACEClinVar, OMIMHGNC link17q23.35PS603933, 608446, 267430, 614519, 104300

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2REN, AGT
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12REN, AGT
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12AGT, AGTR1
SP3NO109DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC62ACE, AGTR1
HIF1ANO80RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A2ACE, AGTR1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
AGTR1YES5SP1, SP3, SND1, ETV4, HIF1A0
AGTYES5SP1, YBX1, NFKB1, USF1, RELA0
RENYES3JUN, PPARG, POU1F10
ACEYES4SP3, HIF1A, CREM, EGR10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
AGTR1ACENo1BDKRB2
AGTRENYes1ATP6AP2
AGTACEYes1EWSR1
RENACENo1AGT

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
AGTR1AGTYesbinding128PLCG1, GPR17, KISS1, EDN1, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, UTS2, EDN3, CYSLTR1, EDN2, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, GNA14, HCRT, LPAR6, FFAR1, GNRH2, GNRHR, F2RL3, GPR68, INS, ANXA1, GRM1, EDNRB, GNAQ, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, LPAR3, ACE2, PROK2, MLN, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, QRFP, XCL2, NTS, LRP2, TRH, GPR132, GRPR, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, FOS, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, TAC1, MCHR2, NMB, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GCGR, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, P2RY2, AVP, P2RY6, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, ARRB1, ADRBK1, NMUR2, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, TACR1, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2
AGTR1RENNo-4INS, KNG1, AGT, EDN1
AGTR1ACENo-5ACE2, NOS3, AGT, SOD3, BDKRB2
AGTRENYesactivation, binding5INS, ATP6AP2, IL6, KNG1, EDN1
AGTACEYesbinding2ACE2, BDKRB2
RENACENo-1AGT

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
AGTRENYes2REN, AGT
AGTACEYes2AGT, ACE
RENACENo1AGT

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Renin-angiotensin systemhsa046148.684REN, AGT, ACE, AGTR1

NET-GE enrichment

Term New enriched termICP valueGenes
Renin-angiotensin system (hsa04614) -8.680.0REN, AGT, ACE, AGTR1
Excretory systemNEW5.450.015REN, AGT, AGTR1
Infectious diseases: ParasiticNEW4.460.005REN, AGT, ACE, AGTR1
Endocrine systemNEW3.260.002REN, AGT, ACE, AGTR1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of Angiotensinogen to AngiotensinsR-HSA-20223778.983REN, AGT, ACE
Metabolism of proteinsR-HSA-3924993.413REN, AGT, ACE
Peptide hormone metabolismR-HSA-29807366.613REN, AGT, ACE
Signaling by GPCRR-HSA-3727902.682AGT, AGTR1
GPCR downstream signalingR-HSA-3883963.072AGT, AGTR1
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692AGT, AGTR1
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262AGT, AGTR1
Peptide ligand-binding receptorsR-HSA-3752765.412AGT, AGTR1
G alpha (q) signalling eventsR-HSA-4164765.422AGT, AGTR1
GPCR ligand bindingR-HSA-5007924.192AGT, AGTR1
Signal TransductionR-HSA-1625821.782AGT, AGTR1

NET-GE enrichment

Term New enriched termICP valueGenes
PPARA activates gene expression (R-HSA-1989781) NEW6.180.009REN, AGT, ACE
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206) NEW6.140.01REN, AGT, ACE
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377) -8.980.0REN, AGT, ACE
Peptide hormone metabolism (R-HSA-2980736) -6.610.0REN, AGT, ACE
Fatty acid, triacylglycerol, and ketone body metabolism (R-HSA-535734) NEW5.440.05REN, AGT, ACE
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
receptor binding (GO:0005102) 2.434REN, AGT, ACE, AGTR1
binding (GO:0005488) 0.184REN, AGT, ACE, AGTR1
protein binding (GO:0005515) 0.464REN, AGT, ACE, AGTR1
G-protein coupled receptor binding (GO:0001664) 4.183AGT, ACE, AGTR1
hydrolase activity (GO:0016787) 1.92REN, ACE
endopeptidase activity (GO:0004175) 3.632REN, ACE
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.262REN, ACE
catalytic activity (GO:0003824) 1.052REN, ACE
(GO:0031711) 8.642ACE, AGTR1
signal transducer activity (GO:0004871) 2.282AGT, AGTR1
peptidase activity (GO:0008233) 3.232REN, ACE

NET-GE enrichment

Term New enriched termICP valueGenes
sulfur compound binding (GO:1901681) NEW4.320.048AGT, ACE, AGTR1
insulin-like growth factor receptor binding (GO:0005159) NEW7.030.003REN, AGT
carboxypeptidase activity (GO:0004180) NEW6.00.028AGT, ACE
glycosaminoglycan binding (GO:0005539) NEW4.420.037AGT, ACE, AGTR1
bradykinin receptor binding (GO:0031711) -8.640.0AGT, ACE, AGTR1
protein kinase C binding (GO:0005080) NEW5.830.045AGT, AGTR1
G-protein coupled receptor binding (GO:0001664) -4.180.043AGT, ACE, AGTR1
receptor binding (GO:0005102) -2.430.002REN, AGT, ACE, AGTR1
heparin binding (GO:0008201) NEW4.680.017AGT, ACE, AGTR1
oxidoreductase activity (GO:0016491) NEW3.120.031REN, AGT, ACE, AGTR1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) 6.364REN, AGT, ACE, AGTR1
regulation of primary metabolic process (GO:0080090) 1.084REN, AGT, ACE, AGTR1
regulation of metabolic process (GO:0019222) 1.024REN, AGT, ACE, AGTR1
regulation of cellular metabolic process (GO:0031323) 1.074REN, AGT, ACE, AGTR1
regulation of blood pressure (GO:0008217) 4.724REN, AGT, ACE, AGTR1
regulation of biological process (GO:0050789) 0.454REN, AGT, ACE, AGTR1
single-organism process (GO:0044699) 0.484REN, AGT, ACE, AGTR1
regulation of systemic arterial blood pressure (GO:0003073) 5.994REN, AGT, ACE, AGTR1
endocrine process (GO:0050886) 6.434REN, AGT, ACE, AGTR1
regulation of protein metabolic process (GO:0051246) 1.934REN, AGT, ACE, AGTR1
kidney development (GO:0001822) 4.794REN, AGT, ACE, AGTR1
animal organ development (GO:0048513) 2.534REN, AGT, ACE, AGTR1
biological regulation (GO:0065007) 0.394REN, AGT, ACE, AGTR1
regulation of biological quality (GO:0065008) 1.684REN, AGT, ACE, AGTR1
developmental process (GO:0032502) 1.364REN, AGT, ACE, AGTR1
multicellular organismal process (GO:0032501) 1.454REN, AGT, ACE, AGTR1
regulation of macromolecule metabolic process (GO:0060255) 1.084REN, AGT, ACE, AGTR1
cellular process (GO:0009987) 0.264REN, AGT, ACE, AGTR1
regulation of cellular process (GO:0050794) 0.54REN, AGT, ACE, AGTR1
single-organism developmental process (GO:0044767) 1.494REN, AGT, ACE, AGTR1
single-organism cellular process (GO:0044763) 0.654REN, AGT, ACE, AGTR1
regulation of systemic arterial blood pressure by hormone (GO:0001990) 6.434REN, AGT, ACE, AGTR1
system process (GO:0003008) 2.34REN, AGT, ACE, AGTR1
regulation of cellular protein metabolic process (GO:0032268) 1.994REN, AGT, ACE, AGTR1
anatomical structure development (GO:0048856) 1.584REN, AGT, ACE, AGTR1
regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) 7.164REN, AGT, ACE, AGTR1
regulation of tube size (GO:0035150) 4.793AGT, ACE, AGTR1
regulation of phosphate metabolic process (GO:0019220) 2.353REN, AGT, ACE
positive regulation of metabolic process (GO:0009893) 1.743AGT, ACE, AGTR1
positive regulation of cellular metabolic process (GO:0031325) 1.813AGT, ACE, AGTR1
regulation of response to stimulus (GO:0048583) 1.543REN, AGT, AGTR1
regulation of vasoconstriction (GO:0019229) 5.513AGT, ACE, AGTR1
regulation of cellular component organization (GO:0051128) 2.013AGT, ACE, AGTR1
metabolic process (GO:0008152) 0.583REN, AGT, ACE
cellular nitrogen compound metabolic process (GO:0034641) 1.223REN, AGT, ACE
nitrogen compound metabolic process (GO:0006807) 1.133REN, AGT, ACE
renal system process (GO:0003014) 5.173REN, AGT, AGTR1
signal transduction (GO:0007165) 1.283REN, AGT, AGTR1
vascular process in circulatory system (GO:0003018) 4.653AGT, ACE, AGTR1
regulation of vasodilation (GO:0042312) 5.863AGT, ACE, AGTR1
positive regulation of catalytic activity (GO:0043085) 2.43AGT, ACE, AGTR1
hormone metabolic process (GO:0042445) 4.643REN, AGT, ACE
peptide hormone processing (GO:0016486) 6.293REN, AGT, ACE
renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) 6.683REN, AGT, AGTR1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813AGT, ACE, AGTR1
regulation of system process (GO:0044057) 3.533AGT, ACE, AGTR1
angiotensin maturation (GO:0002003) 7.333REN, AGT, ACE
positive regulation of protein metabolic process (GO:0051247) 2.433AGT, ACE, AGTR1
regulation of anatomical structure size (GO:0090066) 3.783AGT, ACE, AGTR1
organic substance metabolic process (GO:0071704) 0.633REN, AGT, ACE
positive regulation of cellular protein metabolic process (GO:0032270) 2.493AGT, ACE, AGTR1
positive regulation of molecular function (GO:0044093) 2.233AGT, ACE, AGTR1
regulation of protein modification process (GO:0031399) 2.323REN, AGT, ACE
positive regulation of biological process (GO:0048518) 1.23AGT, ACE, AGTR1
proteolysis (GO:0006508) 2.733REN, AGT, ACE
regulation of molecular function (GO:0065009) 1.783AGT, ACE, AGTR1
regulation of cell proliferation (GO:0042127) 2.413AGT, ACE, AGTR1
regulation of catalytic activity (GO:0050790) 1.973AGT, ACE, AGTR1
regulation of hormone levels (GO:0010817) 3.563REN, AGT, ACE
regulation of phosphorus metabolic process (GO:0051174) 2.353REN, AGT, ACE
reproductive process (GO:0022414) 2.553REN, AGT, ACE
regulation of blood vessel size (GO:0050880) 4.83AGT, ACE, AGTR1
regulation of blood circulation (GO:1903522) 4.053AGT, ACE, AGTR1
regulation of multicellular organismal process (GO:0051239) 1.873AGT, ACE, AGTR1
protein processing (GO:0016485) 4.623REN, AGT, ACE
regulation of localization (GO:0032879) 1.943AGT, ACE, AGTR1
regulation of phosphorylation (GO:0042325) 2.53REN, AGT, ACE
primary metabolic process (GO:0044238) 0.693REN, AGT, ACE
organonitrogen compound metabolic process (GO:1901564) 2.323REN, AGT, ACE
protein maturation (GO:0051604) 4.483REN, AGT, ACE
single-multicellular organism process (GO:0044707) 1.783AGT, ACE, AGTR1
renin-angiotensin regulation of aldosterone production (GO:0002018) 8.343REN, AGT, AGTR1
protein metabolic process (GO:0019538) 1.453REN, AGT, ACE
regulation of blood volume by renin-angiotensin (GO:0002016) 7.653REN, AGT, ACE
cellular metabolic process (GO:0044237) 0.693REN, AGT, ACE
macromolecule metabolic process (GO:0043170) 0.833REN, AGT, ACE
circulatory system process (GO:0003013) 4.383AGT, ACE, AGTR1
cellular amide metabolic process (GO:0043603) 3.233REN, AGT, ACE
peptide metabolic process (GO:0006518) 3.443REN, AGT, ACE
regulation of protein phosphorylation (GO:0001932) 2.573REN, AGT, ACE
positive regulation of cellular process (GO:0048522) 1.33AGT, ACE, AGTR1
regulation of secretion (GO:0051046) 3.22AGT, AGTR1
angiotensin-activated signaling pathway (GO:0038166) 7.092AGT, AGTR1
regulation of transport (GO:0051049) 2.242AGT, AGTR1
positive regulation of response to stimulus (GO:0048584) 2.182AGT, AGTR1
tissue remodeling (GO:0048771) 5.542AGT, ACE
behavior (GO:0007610) 3.472REN, AGT
regulation of homeostatic process (GO:0032844) 3.652AGT, AGTR1
positive regulation of defense response (GO:0031349) 3.832AGT, AGTR1
inorganic ion homeostasis (GO:0098771) 3.432AGT, AGTR1
regulation of defense response (GO:0031347) 3.112AGT, AGTR1
single-organism metabolic process (GO:0044710) 1.632AGT, ACE
positive regulation of inflammatory response (GO:0050729) 4.982AGT, AGTR1
regulation of signal transduction (GO:0009966) 1.842REN, AGT
cellular developmental process (GO:0048869) 1.822REN, ACE
regulation of inflammatory response (GO:0050727) 4.032AGT, AGTR1
positive regulation of lipid metabolic process (GO:0045834) 4.882AGT, AGTR1
negative regulation of biological process (GO:0048519) 1.332AGT, ACE
cellular homeostasis (GO:0019725) 3.232AGT, AGTR1
positive regulation of phospholipase activity (GO:0010518) 5.762AGT, AGTR1
macromolecular complex remodeling (GO:0034367) 6.552AGT, AGTR1
protein-lipid complex remodeling (GO:0034368) 6.552AGT, AGTR1
plasma lipoprotein particle remodeling (GO:0034369) 6.552AGT, AGTR1
regulation of protein kinase activity (GO:0045859) 3.152AGT, ACE
protein catabolic process (GO:0030163) 3.932REN, ACE
drinking behavior (GO:0042756) 7.532REN, AGT
(GO:0010872) 7.432AGT, AGTR1
(GO:0010873) 7.652AGT, AGTR1
positive regulation of phosphorylation (GO:0042327) 2.92AGT, ACE
single organism reproductive process (GO:0044702) 2.732REN, ACE
response to external stimulus (GO:0009605) 2.552REN, AGT
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622AGT, ACE
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352AGT, ACE
positive regulation of oxidoreductase activity (GO:0051353) 5.942AGT, AGTR1
phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 5.382AGT, AGTR1
feeding behavior (GO:0007631) 5.212REN, AGT
low-density lipoprotein particle remodeling (GO:0034374) 7.332AGT, AGTR1
positive regulation of kinase activity (GO:0033674) 3.542AGT, ACE
second-messenger-mediated signaling (GO:0019932) 4.652AGT, AGTR1
intracellular signal transduction (GO:0035556) 2.392AGT, AGTR1
chemical homeostasis (GO:0048878) 2.972AGT, AGTR1
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure (GO:0003072) 8.632AGT, AGTR1
regulation of oxidoreductase activity (GO:0051341) 5.272AGT, AGTR1
regulation of cell communication (GO:0010646) 1.732REN, AGT
positive regulation of transferase activity (GO:0051347) 3.312AGT, ACE
positive regulation of hydrolase activity (GO:0051345) 2.912AGT, AGTR1
regulation of kinase activity (GO:0043549) 3.072AGT, ACE
cellular component organization (GO:0016043) 1.242AGT, AGTR1
cellular component organization or biogenesis (GO:0071840) 1.222AGT, AGTR1
regulation of protein tyrosine kinase activity (GO:0061097) 5.592AGT, ACE
positive regulation of protein tyrosine kinase activity (GO:0061098) 6.072AGT, ACE
G-protein coupled receptor signaling pathway (GO:0007186) 2.642AGT, AGTR1
positive regulation of reactive oxygen species metabolic process (GO:2000379) 5.292AGT, AGTR1
regulation of developmental process (GO:0050793) 2.12AGT, ACE
transport (GO:0006810) 1.512AGT, ACE
cellular response to stimulus (GO:0051716) 1.972REN, AGT
regulation of reactive oxygen species metabolic process (GO:2000377) 4.712AGT, AGTR1
response to stress (GO:0006950) 1.82REN, AGT
regulation of intracellular signal transduction (GO:1902531) 2.312REN, AGT
regulation of hydrolase activity (GO:0051336) 2.532AGT, AGTR1
secretion (GO:0046903) 3.382AGT, ACE
regulation of response to stress (GO:0080134) 2.532AGT, AGTR1
positive regulation of protein modification process (GO:0031401) 2.72AGT, ACE
(GO:0033864) 8.632AGT, AGTR1
blood vessel remodeling (GO:0001974) 6.232AGT, ACE
regulation of cell motility (GO:2000145) 3.162AGT, ACE
positive regulation of lipase activity (GO:0060193) 5.542AGT, AGTR1
regulation of lipase activity (GO:0060191) 5.312AGT, AGTR1
positive regulation of response to external stimulus (GO:0032103) 4.172AGT, AGTR1
regulation of response to external stimulus (GO:0032101) 3.062AGT, AGTR1
ion homeostasis (GO:0050801) 3.422AGT, AGTR1
regulation of signaling (GO:0023051) 1.722REN, AGT
beta-amyloid metabolic process (GO:0050435) 7.092REN, ACE
establishment of localization (GO:0051234) 1.482AGT, ACE
positive regulation of phosphorus metabolic process (GO:0010562) 2.782AGT, ACE
localization (GO:0051179) 1.42AGT, ACE
cell proliferation (GO:0008283) 3.232AGT, ACE
cellular metal ion homeostasis (GO:0006875) 3.752AGT, AGTR1
cellular ion homeostasis (GO:0006873) 3.572AGT, AGTR1
positive regulation of cell differentiation (GO:0045597) 3.012AGT, AGTR1
regulation of cell differentiation (GO:0045595) 2.422AGT, AGTR1
regulation of cell growth (GO:0001558) 3.752AGT, AGTR1
cellular cation homeostasis (GO:0030003) 3.62AGT, AGTR1
cation homeostasis (GO:0055080) 3.462AGT, AGTR1
cellular chemical homeostasis (GO:0055082) 3.42AGT, AGTR1
regulation of excretion (GO:0044062) 6.362AGT, AGTR1
positive regulation of steroid metabolic process (GO:0045940) 6.592AGT, AGTR1
regulation of blood vessel size by renin-angiotensin (GO:0002034) 8.632AGT, AGTR1
positive regulation of protein kinase activity (GO:0045860) 3.612AGT, ACE
response to stimulus (GO:0050896) 1.222REN, AGT
macromolecular complex subunit organization (GO:0043933) 2.142AGT, AGTR1
regulation of NAD(P)H oxidase activity (GO:0033860) 7.942AGT, AGTR1
homeostatic process (GO:0042592) 2.612AGT, AGTR1
regulation of transferase activity (GO:0051338) 2.882AGT, ACE
protein-lipid complex subunit organization (GO:0071825) 6.152AGT, AGTR1
plasma lipoprotein particle organization (GO:0071827) 6.232AGT, AGTR1
regulation of cellular component biogenesis (GO:0044087) 3.082AGT, ACE
regulation of growth (GO:0040008) 3.262AGT, AGTR1
regulation of cell junction assembly (GO:1901888) 5.492AGT, ACE
regulation of renal system process (GO:0098801) 6.122AGT, AGTR1
regulation of locomotion (GO:0040012) 3.122AGT, ACE
organic substance transport (GO:0071702) 2.152AGT, ACE
positive regulation of macrophage derived foam cell differentiation (GO:0010744) 7.022AGT, AGTR1
regulation of renal sodium excretion (GO:0035813) 6.552AGT, AGTR1
regulation of macrophage derived foam cell differentiation (GO:0010743) 6.42AGT, AGTR1
regulation of cell migration (GO:0030334) 3.232AGT, ACE
positive regulation of phosphate metabolic process (GO:0045937) 2.782AGT, ACE
regulation of lipid metabolic process (GO:0019216) 4.082AGT, AGTR1
regulation of steroid metabolic process (GO:0019218) 5.422AGT, AGTR1
organic substance catabolic process (GO:1901575) 2.452REN, ACE
single-organism transport (GO:0044765) 2.182AGT, ACE
metal ion homeostasis (GO:0055065) 3.612AGT, AGTR1
catabolic process (GO:0009056) 2.382REN, ACE
macromolecule catabolic process (GO:0009057) 3.02REN, ACE
single-organism localization (GO:1902578) 2.092AGT, ACE
regulation of cellular component movement (GO:0051270) 3.082AGT, ACE
regulation of renal output by angiotensin (GO:0002019) 8.632AGT, ACE
regulation of gap junction assembly (GO:1903596) 8.342AGT, ACE
regulation of ion homeostasis (GO:2000021) 4.442AGT, AGTR1
regulation of multicellular organismal development (GO:2000026) 2.312AGT, ACE
regulation of phospholipase activity (GO:0010517) 5.572AGT, AGTR1
positive regulation of protein phosphorylation (GO:0001934) 2.952AGT, ACE
negative regulation of cellular process (GO:0048523) 1.412AGT, ACE

NET-GE enrichment

Term New enriched termICP valueGenes
low-density lipoprotein particle remodeling (GO:0034374) -7.330.001AGT, AGTR1
plasma lipoprotein particle remodeling (GO:0034369) -6.550.005AGT, AGTR1
regulation of lipid biosynthetic process (GO:0046890) NEW4.870.047REN, AGT, ACE
regulation of vasoconstriction (GO:0019229) -5.510.0REN, AGT, ACE, AGTR1
regulation of homeostatic process (GO:0032844) -3.650.018REN, AGT, ACE, AGTR1
protein processing (GO:0016485) -4.620.003REN, AGT, ACE
anion transport (GO:0006820) NEW3.710.02REN, AGT, ACE, AGTR1
renal system process (GO:0003014) -5.170.01REN, AGT, AGTR1
positive regulation of NAD(P)H oxidase activity (GO:0033864) -8.630.001AGT, AGTR1
response to heat (GO:0009408) NEW5.240.01REN, AGT, ACE
regulation of renal output by angiotensin (GO:0002019) -8.630.0AGT, ACE
peptide hormone processing (GO:0016486) -6.290.001REN, AGT, ACE
regulation of inflammatory response (GO:0050727) -4.030.004REN, AGT, ACE, AGTR1
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure (GO:0003072) -8.630.001AGT, AGTR1
hormone metabolic process (GO:0042445) -4.640.001REN, AGT, ACE
plasma lipoprotein particle organization (GO:0071827) -6.230.009AGT, AGTR1
endocrine process (GO:0050886) -6.430.0AGT, ACE, AGTR1
regulation of system process (GO:0044057) -3.530.018REN, AGT, ACE, AGTR1
regulation of blood vessel size by renin-angiotensin (GO:0002034) -8.630.001AGT, AGTR1
actin cytoskeleton reorganization (GO:0031532) NEW5.840.0AGT, ACE, AGTR1
blood vessel remodeling (GO:0001974) -6.230.013AGT, ACE
angiotensin maturation (GO:0002003) -7.330.0REN, AGT, ACE
mesonephros development (GO:0001823) NEW7.160.017REN, AGT
kidney development (GO:0001822) -4.790.001REN, AGT, ACE, AGTR1
positive regulation of apoptotic process (GO:0043065) NEW3.380.04REN, AGT, ACE, AGTR1
positive regulation of steroid biosynthetic process (GO:0010893) NEW7.160.027AGT, ACE
organ development (GO:0048513) -2.530.008REN, AGT, ACE, AGTR1
positive regulation of lipid metabolic process (GO:0045834) -4.880.024AGT, ACE, AGTR1
regulation of steroid metabolic process (GO:0019218) -5.420.0REN, AGT, ACE, AGTR1
positive regulation of macrophage derived foam cell differentiation (GO:0010744) -7.020.045AGT, AGTR1
regulation of renal sodium excretion (GO:0035813) -6.550.004AGT, AGTR1
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) -6.360.0AGT, ACE, AGTR1
regulation of response to wounding (GO:1903034) NEW4.740.023REN, AGT, ACE, AGTR1
positive regulation of programmed cell death (GO:0043068) NEW3.380.041REN, AGT, ACE, AGTR1
positive regulation of response to wounding (GO:1903036) NEW5.760.03REN, AGT, AGTR1
regulation of macrophage derived foam cell differentiation (GO:0010743) -6.40.007AGT, AGTR1
regulation of tube size (GO:0035150) -4.790.038AGT, AGTR1
positive regulation of reactive oxygen species metabolic process (GO:2000379) -5.290.013AGT, AGTR1
renal system process involved in regulation of systemic arterial blood pressure (GO:0003071) -6.680.0REN, AGT, AGTR1
regulation of systemic arterial blood pressure (GO:0003073) -5.990.0AGT, ACE, AGTR1
protein-lipid complex remodeling (GO:0034368) -6.550.005AGT, AGTR1
regulation of excretion (GO:0044062) -6.360.048AGT, AGTR1
cellular response to reactive oxygen species (GO:0034614) NEW5.220.015AGT, ACE, AGTR1
organic anion transport (GO:0015711) NEW4.070.005REN, AGT, ACE, AGTR1
regulation of hormone levels (GO:0010817) -3.560.004REN, AGT, ACE, AGTR1
regulation of vasodilation (GO:0042312) -5.860.016AGT, ACE, AGTR1
regulation of blood vessel size (GO:0050880) -4.80.037AGT, AGTR1
regulation of steroid biosynthetic process (GO:0050810) NEW5.840.005REN, AGT, ACE
drinking behavior (GO:0042756) -7.530.003REN, AGT
regulation of cholesterol esterification (GO:0010872) -7.430.006AGT, AGTR1
positive regulation of cholesterol esterification (GO:0010873) -7.650.003AGT, AGTR1
regulation of carbohydrate biosynthetic process (GO:0043255) NEW5.250.013REN, AGT, ACE
tissue remodeling (GO:0048771) -5.540.05AGT, ACE
system process (GO:0003008) -2.30.008REN, AGT, ACE, AGTR1
protein-lipid complex subunit organization (GO:0071825) -6.150.01AGT, AGTR1
regulation of systemic arterial blood pressure by hormone (GO:0001990) -6.430.0AGT, ACE, AGTR1
cellular amide metabolic process (GO:0043603) -3.230.047REN, AGT, ACE
protein maturation (GO:0051604) -4.480.004REN, AGT, ACE
renin-angiotensin regulation of aldosterone production (GO:0002018) -8.340.0REN, AGT, AGTR1
regulation of blood volume by renin-angiotensin (GO:0002016) -7.650.003AGT, ACE
macromolecular complex remodeling (GO:0034367) -6.550.005AGT, AGTR1
regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) -7.160.0AGT, ACE, AGTR1
positive regulation of oxidoreductase activity (GO:0051353) -5.940.013AGT, AGTR1
positive regulation of steroid metabolic process (GO:0045940) -6.590.0AGT, ACE, AGTR1
positive regulation of inflammatory response (GO:0050729) -4.980.013REN, AGT, AGTR1
phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) -5.380.026AGT, AGTR1
regulation of blood pressure (GO:0008217) -4.720.0REN, AGT, ACE, AGTR1
peptide metabolic process (GO:0006518) -3.440.009REN, AGT, ACE
regulation of NAD(P)H oxidase activity (GO:0033860) -7.940.003AGT, AGTR1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.114REN, AGT, ACE, AGTR1
cytoplasm (GO:0005737) 1.013REN, AGT, ACE
extracellular space (GO:0005615) 2.633REN, AGT, ACE
membrane (GO:0016020) 0.683REN, ACE, AGTR1
extracellular region part (GO:0044421) 1.573REN, AGT, ACE
extracellular region (GO:0005576) 2.183REN, AGT, ACE
plasma membrane (GO:0005886) 1.393REN, ACE, AGTR1
intracellular part (GO:0044424) 0.283REN, AGT, ACE
membrane-bounded organelle (GO:0043227) 0.473REN, AGT, ACE
organelle (GO:0043226) 0.43REN, AGT, ACE
intracellular (GO:0005622) 2.372REN, AGTR1
lytic vacuole (GO:0000323) 3.892REN, ACE
vesicle (GO:0031982) 1.642AGT, ACE
vacuole (GO:0005773) 2.922REN, ACE
extracellular exosome (GO:0070062) 1.892AGT, ACE
integral component of membrane (GO:0016021) 1.142ACE, AGTR1
cytoplasmic part (GO:0044444) 0.822REN, ACE
membrane-bounded vesicle (GO:0031988) 1.712AGT, ACE
lysosome (GO:0005764) 3.892REN, ACE
intracellular organelle (GO:0043229) 0.512REN, ACE
membrane part (GO:0044425) 0.952ACE, AGTR1
extracellular organelle (GO:0043230) 1.892AGT, ACE
extracellular vesicle (GO:1903561) 1.892AGT, ACE
plasma membrane part (GO:0044459) 1.952ACE, AGTR1
intrinsic component of membrane (GO:0031224) 1.132ACE, AGTR1
intracellular membrane-bounded organelle (GO:0043231) 0.62REN, ACE

NET-GE enrichment

Term New enriched termICP valueGenes
receptor complex (GO:0043235) NEW4.010.042REN, AGT, AGTR1
extracellular space (GO:0005615) -2.630.023REN, AGT, ACE
organelle lumen (GO:0043233) NEW3.050.017REN, AGT, ACE, AGTR1
membrane-enclosed lumen (GO:0031974) NEW3.050.023REN, AGT, ACE, AGTR1
synapse (GO:0045202) NEW3.580.041REN, AGT, AGTR1
endosome (GO:0005768) NEW3.250.004REN, AGT, ACE, AGTR1