| Disease ID | Disease name | Source of annotation with AGT | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS189800 | PREECLAMPSIA/ECLAMPSIA | OMIM | link to OMIM | 5 | EPHX1, STOX1, AGT, NOS3, CORIN |
| 145500 | HYPERTENSION, ESSENTIAL | OMIM | link to OMIM | 13 | RGS5, PTGIS, ADD1, NOS3, UMOD, AGT, ECE1, CYP3A5, ATP1B1, NOS2, GNB3, AGTR1, SELE |
| 267430 | RENAL TUBULAR DYSGENESIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 4 | REN, AGT, ACE, AGTR1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Renin-angiotensin system | hsa04614 | 8.68 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| PPARA activates gene expression | R-HSA-1989781 | 6.18 |
| Metabolism of Angiotensinogen to Angiotensins | R-HSA-2022377 | 8.98 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Fatty acid, triacylglycerol, and ketone body metabolism | R-HSA-535734 | 5.44 |
| G alpha (i) signalling events | R-HSA-418594 | 5.1 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
| Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | R-HSA-400206 | 6.14 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| superoxide-generating NADPH oxidase activator activity | GO:0016176 | 8.13 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| G-protein coupled receptor binding | GO:0001664 | 4.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| growth factor activity | GO:0008083 | 4.66 |
| receptor regulator activity | GO:0030545 | 5.91 |
| receptor activator activity | GO:0030546 | 6.27 |
| channel regulator activity | GO:0016247 | 4.88 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |
| hormone activity | GO:0005179 | 4.95 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| angiotensin receptor binding | GO:0031701 | 7.25 |
| receptor agonist activity | GO:0048018 | 6.97 |
| GO:0031703 | 9.74 | |
| type 1 angiotensin receptor binding | GO:0031702 | 7.44 |
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| serine-type endopeptidase inhibitor activity | GO:0004867 | 5.16 |
| sodium channel regulator activity | GO:0017080 | 6.3 |
| protein binding | GO:0005515 | 0.46 |
| receptor binding | GO:0005102 | 2.43 |
| enzyme activator activity | GO:0008047 | 3.56 |