Disease ID | Disease name | Source of annotation with TNFRSF11A | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS259700 | OSTEOPETROSIS, AUTOSOMAL RECESSIVE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 8 | TNFRSF11A, TNFSF11, SNX10, PLEKHM1, CA2, CLCN7, OSTM1, TCIRG1 |
174810 | FAMILIAL EXPANSILE OSTEOLYSIS | ClinVar, OMIM | link to OMIM | 1 | TNFRSF11A |
PS167250 | PAGET DISEASE OF BONE | ClinVar, OMIM | link to OMIM | 4 | TNFRSF11A, SQSTM1, TNFRSF11B, ZNF687 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Rheumatoid arthritis | hsa05323 | 6.05 |
NF-kappa B signaling pathway | hsa04064 | 6.21 |
Prolactin signaling pathway | hsa04917 | 6.6 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
Osteoclast differentiation | hsa04380 | 5.64 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 6.4 |
Immune System | R-HSA-168256 | 2.37 |
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | R-HSA-5676594 | 8.89 |
GO term | GO ID | GO IC |
---|---|---|
binding | GO:0005488 | 0.18 |
cation binding | GO:0043169 | 1.4 |
signaling receptor activity | GO:0038023 | 2.49 |
protein binding | GO:0005515 | 0.46 |
molecular transducer activity | GO:0060089 | 2.32 |
cytokine binding | GO:0019955 | 5.21 |
ion binding | GO:0043167 | 1.36 |
death receptor activity | GO:0005035 | 6.56 |
transmembrane signaling receptor activity | GO:0004888 | 2.57 |
tumor necrosis factor-activated receptor activity | GO:0005031 | 6.56 |
signal transducer activity | GO:0004871 | 2.28 |
metal ion binding | GO:0046872 | 1.41 |
transmembrane receptor activity | GO:0099600 | 2.53 |
receptor activity | GO:0004872 | 2.32 |