Disease table of OSTEOPETROSIS, AUTOSOMAL RECESSIVE OMIM ID: PS259700

Gene-disease associations table

GeneAssociated with OSTEOPETROSIS, AUTOSOMAL RECESSIVE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
OSTM1ClinVar, OMIMHGNC link6q211PS259700
TNFSF11ClinVar, OMIM, HUMSAVARHGNC link13q14.111PS259700
SNX10ClinVar, OMIM, HUMSAVARHGNC link7p15.21PS259700
CA2ClinVar, OMIM, HUMSAVARHGNC link8q21.21PS259700
CLCN7ClinVar, OMIM, HUMSAVARHGNC link16p13.32PS259700, PS607634
TCIRG1ClinVar, OMIM, HUMSAVARHGNC link11q13.21PS259700
PLEKHM1ClinVar, OMIMHGNC link17q21.311PS259700
TNFRSF11AClinVar, OMIM, HUMSAVARHGNC link18q21.333PS259700, 174810, PS167250

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TNFSF11YES4VDR, E2F1, HSF2, DACH10
CA2YES1JUN0
TNFRSF11AYES1SPI10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
OSTM1SNX10No1ELAVL1
OSTM1CLCN7No4ATP6AP2, LGALS8, FAM177A1, BIRC7
OSTM1TCIRG1No1ATP6AP2
CA2TCIRG1No1EWSR1
CLCN7TCIRG1No2ATP6AP2, GOLT1B

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
OSTM1CLCN7Yesbinding1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Rheumatoid arthritishsa053236.053TNFRSF11A, TCIRG1, TNFSF11
Collecting duct acid secretionhsa049667.912CA2, TCIRG1
NF-kappa B signaling pathwayhsa040646.212TNFRSF11A, TNFSF11
Prolactin signaling pathwayhsa049176.62TNFRSF11A, TNFSF11
Cytokine-cytokine receptor interactionhsa040604.672TNFRSF11A, TNFSF11
Osteoclast differentiationhsa043805.642TNFRSF11A, TNFSF11

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.013TNFRSF11A, TCIRG1, TNFSF11
Rheumatoid arthritis (hsa05323) -6.050.003TNFRSF11A, TCIRG1, TNFSF11
NF-kappa B signaling pathway (hsa04064) -6.210.039TNFRSF11A, TNFSF11
Prolactin signaling pathway (hsa04917) -6.60.023TNFRSF11A, TNFSF11
Collecting duct acid secretion (hsa04966) -7.910.004CA2, TCIRG1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Ion channel transportR-HSA-9837125.343TCIRG1, OSTM1, CLCN7
Transmembrane transport of small moleculesR-HSA-3825513.793TCIRG1, OSTM1, CLCN7
Cytokine Signaling in Immune systemR-HSA-12802153.742TNFRSF11A, TNFSF11
TNFR2 non-canonical NF-kB pathwayR-HSA-56685416.42TNFRSF11A, TNFSF11
Stimuli-sensing channelsR-HSA-26723516.282OSTM1, CLCN7
Immune SystemR-HSA-1682562.372TNFRSF11A, TNFSF11
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayR-HSA-56765948.892TNFRSF11A, TNFSF11

NET-GE enrichment

Term New enriched termICP valueGenes
Ion channel transport (R-HSA-983712) -5.340.042TCIRG1, OSTM1, CLCN7
TNFR2 non-canonical NF-kB pathway (R-HSA-5668541) -6.40.047TNFRSF11A, TNFSF11
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (R-HSA-5676594) -8.890.003TNFRSF11A, TNFSF11
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187CA2, PLEKHM1, TNFRSF11A, TCIRG1, SNX10, TNFSF11, CLCN7
protein binding (GO:0005515) 0.465CA2, TNFRSF11A, TCIRG1, SNX10, TNFSF11
cation binding (GO:0043169) 1.43PLEKHM1, TNFRSF11A, CA2
metal ion binding (GO:0046872) 1.413PLEKHM1, TNFRSF11A, CA2
ion binding (GO:0043167) 1.363CA2, TNFRSF11A, PLEKHM1
substrate-specific transmembrane transporter activity (GO:0022891) 2.92TCIRG1, CLCN7
hydrolase activity (GO:0016787) 1.92CA2, TCIRG1
substrate-specific transporter activity (GO:0022892) 2.722TCIRG1, CLCN7
ATPase binding (GO:0051117) 5.412TCIRG1, SNX10
enzyme binding (GO:0019899) 2.272TCIRG1, SNX10
ion transmembrane transporter activity (GO:0015075) 3.042TCIRG1, CLCN7
catalytic activity (GO:0003824) 1.052CA2, TCIRG1
transmembrane transporter activity (GO:0022857) 2.822TCIRG1, CLCN7
transporter activity (GO:0005215) 2.572TCIRG1, CLCN7
active transmembrane transporter activity (GO:0022804) 3.852TCIRG1, CLCN7
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.267CA2, PLEKHM1, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11
transport (GO:0006810) 1.516CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
localization (GO:0051179) 1.46CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
single-organism cellular process (GO:0044763) 0.656CA2, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11
biological regulation (GO:0065007) 0.396CA2, PLEKHM1, TNFRSF11A, TCIRG1, TNFSF11, CLCN7
establishment of localization (GO:0051234) 1.486CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
regulation of biological process (GO:0050789) 0.456CA2, PLEKHM1, TNFRSF11A, TCIRG1, TNFSF11, CLCN7
single-organism process (GO:0044699) 0.486CA2, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11
response to stimulus (GO:0050896) 1.225CA2, TNFRSF11A, TCIRG1, CLCN7, TNFSF11
signal transduction (GO:0007165) 1.285PLEKHM1, TNFRSF11A, TCIRG1, CA2, TNFSF11
regulation of cellular process (GO:0050794) 0.55PLEKHM1, TNFRSF11A, TCIRG1, CA2, TNFSF11
developmental process (GO:0032502) 1.364CA2, TNFRSF11A, SNX10, TNFSF11
single-organism developmental process (GO:0044767) 1.494CA2, TNFRSF11A, SNX10, TNFSF11
cell differentiation (GO:0030154) 2.144TNFRSF11A, SNX10, OSTM1, TNFSF11
organic substance transport (GO:0071702) 2.154CA2, PLEKHM1, TCIRG1, SNX10
regulation of transport (GO:0051049) 2.244CA2, TNFRSF11A, CLCN7, TNFSF11
ion transport (GO:0006811) 2.664CA2, TCIRG1, OSTM1, CLCN7
osteoclast differentiation (GO:0030316) 6.514TNFRSF11A, SNX10, OSTM1, TNFSF11
regulation of anion transport (GO:0044070) 5.254CA2, TNFRSF11A, CLCN7, TNFSF11
myeloid leukocyte differentiation (GO:0002573) 5.234TNFRSF11A, SNX10, OSTM1, TNFSF11
homeostatic process (GO:0042592) 2.614CA2, TNFRSF11A, TCIRG1, TNFSF11
regulation of biological quality (GO:0065008) 1.684CA2, TNFRSF11A, TCIRG1, TNFSF11
myeloid cell differentiation (GO:0030099) 4.634TNFRSF11A, SNX10, OSTM1, TNFSF11
regulation of ion transport (GO:0043269) 3.44CA2, TNFRSF11A, CLCN7, TNFSF11
cellular developmental process (GO:0048869) 1.824TNFRSF11A, SNX10, OSTM1, TNFSF11
positive regulation of biological process (GO:0048518) 1.24CA2, TNFRSF11A, TCIRG1, TNFSF11
regulation of localization (GO:0032879) 1.944CA2, TNFRSF11A, CLCN7, TNFSF11
leukocyte differentiation (GO:0002521) 4.134TNFRSF11A, SNX10, OSTM1, TNFSF11
positive regulation of cellular process (GO:0048522) 1.34CA2, TNFRSF11A, TCIRG1, TNFSF11
protein localization (GO:0008104) 2.363PLEKHM1, TCIRG1, SNX10
metabolic process (GO:0008152) 0.583CA2, TCIRG1, TNFSF11
ion homeostasis (GO:0050801) 3.423CA2, TCIRG1, TNFSF11
positive regulation of homeostatic process (GO:0032846) 4.383CA2, TNFRSF11A, TNFSF11
regulation of homeostatic process (GO:0032844) 3.653CA2, TNFRSF11A, TNFSF11
positive regulation of signaling (GO:0023056) 2.413CA2, TNFRSF11A, TNFSF11
cellular component assembly (GO:0022607) 2.143TCIRG1, SNX10, TNFSF11
cell surface receptor signaling pathway (GO:0007166) 2.093TNFRSF11A, TCIRG1, TNFSF11
regulation of signaling (GO:0023051) 1.723CA2, TNFRSF11A, TNFSF11
inorganic ion homeostasis (GO:0098771) 3.433CA2, TCIRG1, TNFSF11
positive regulation of cell communication (GO:0010647) 2.413CA2, TNFRSF11A, TNFSF11
regulation of cell communication (GO:0010646) 1.733CA2, TNFRSF11A, TNFSF11
cellular component organization or biogenesis (GO:0071840) 1.223TCIRG1, SNX10, TNFSF11
single-organism metabolic process (GO:0044710) 1.633CA2, TCIRG1, TNFSF11
positive regulation of multicellular organismal process (GO:0051240) 2.493CA2, TNFRSF11A, TNFSF11
cellular component organization (GO:0016043) 1.243TCIRG1, SNX10, TNFSF11
macromolecule localization (GO:0033036) 2.343PLEKHM1, TCIRG1, SNX10
positive regulation of transport (GO:0051050) 2.93CA2, TNFRSF11A, TNFSF11
establishment of protein localization (GO:0045184) 2.533PLEKHM1, TCIRG1, SNX10
ion transmembrane transport (GO:0034220) 3.083TCIRG1, OSTM1, CLCN7
response to stress (GO:0006950) 1.83CA2, TNFRSF11A, TCIRG1
regulation of multicellular organismal process (GO:0051239) 1.873CA2, TNFRSF11A, TNFSF11
cation homeostasis (GO:0055080) 3.463CA2, TCIRG1, TNFSF11
transmembrane transport (GO:0055085) 2.723TCIRG1, OSTM1, CLCN7
response to abiotic stimulus (GO:0009628) 2.83CA2, TNFRSF11A, CLCN7
anatomical structure development (GO:0048856) 1.583CA2, TNFRSF11A, TNFSF11
cellular metabolic process (GO:0044237) 0.693CA2, TCIRG1, TNFSF11
chemical homeostasis (GO:0048878) 2.973CA2, TCIRG1, TNFSF11
protein transport (GO:0015031) 2.623PLEKHM1, TCIRG1, SNX10
regulation of peptide transport (GO:0090087) 4.372CA2, TNFSF11
regulation of phosphate metabolic process (GO:0019220) 2.352TNFRSF11A, TNFSF11
cytokine-mediated signaling pathway (GO:0019221) 3.62TNFRSF11A, TNFSF11
regulation of secretion (GO:0051046) 3.22TNFRSF11A, TNFSF11
positive regulation of secretion (GO:0051047) 3.852TNFRSF11A, TNFSF11
positive regulation of response to stimulus (GO:0048584) 2.182TNFRSF11A, TNFSF11
regulation of response to stimulus (GO:0048583) 1.542TNFRSF11A, TNFSF11
positive regulation of defense response (GO:0031349) 3.832TNFRSF11A, TNFSF11
anion transport (GO:0006820) 3.712CA2, CLCN7
ossification (GO:0001503) 4.862TNFRSF11A, TNFSF11
small molecule metabolic process (GO:0044281) 2.382CA2, TCIRG1
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling (GO:0071848) 9.042TNFRSF11A, TNFSF11
cell chemotaxis (GO:0060326) 4.632TNFRSF11A, TNFSF11
TNFSF11-mediated signaling pathway (GO:0071847) 8.342TNFRSF11A, TNFSF11
cellular chemical homeostasis (GO:0055082) 3.42CA2, TCIRG1
regulation of defense response (GO:0031347) 3.112TNFRSF11A, TNFSF11
regulation of primary metabolic process (GO:0080090) 1.082TNFRSF11A, TNFSF11
positive regulation of bone resorption (GO:0045780) 7.162CA2, TNFSF11
positive regulation of inflammatory response (GO:0050729) 4.982TNFRSF11A, TNFSF11
regulation of metabolic process (GO:0019222) 1.022TNFRSF11A, TNFSF11
taxis (GO:0042330) 4.032TNFRSF11A, TNFSF11
regulation of signal transduction (GO:0009966) 1.842TNFRSF11A, TNFSF11
positive regulation of signal transduction (GO:0009967) 2.52TNFRSF11A, TNFSF11
regulation of inflammatory response (GO:0050727) 4.032TNFRSF11A, TNFSF11
animal organ development (GO:0048513) 2.532CA2, TNFRSF11A
positive regulation of molecular function (GO:0044093) 2.232TNFRSF11A, TNFSF11
regulation of cell proliferation (GO:0042127) 2.412TNFRSF11A, TCIRG1
leukocyte chemotaxis (GO:0030595) 4.962TNFRSF11A, TNFSF11
chemotaxis (GO:0006935) 4.042TNFRSF11A, TNFSF11
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852TNFRSF11A, TNFSF11
regulation of macromolecule metabolic process (GO:0060255) 1.082TNFRSF11A, TNFSF11
regulation of protein kinase activity (GO:0045859) 3.152TNFRSF11A, TNFSF11
positive regulation of JNK cascade (GO:0046330) 4.982TNFRSF11A, TNFSF11
positive regulation of fever generation by positive regulation of prostaglandin secretion (GO:0071812) 9.042TNFRSF11A, TNFSF11
regulation of RNA biosynthetic process (GO:2001141) 1.552TNFRSF11A, TNFSF11
regulation of acute inflammatory response (GO:0002673) 5.412TNFRSF11A, TNFSF11
regulation of hemopoiesis (GO:1903706) 4.02CA2, TNFSF11
response to organic substance (GO:0010033) 2.22CA2, TNFRSF11A
positive regulation of acute inflammatory response (GO:0002675) 6.362TNFRSF11A, TNFSF11
regulation of phosphorylation (GO:0042325) 2.52TNFRSF11A, TNFSF11
single organism signaling (GO:0044700) 3.252TNFRSF11A, TNFSF11
positive regulation of phosphorylation (GO:0042327) 2.92TNFRSF11A, TNFSF11
single-multicellular organism process (GO:0044707) 1.782TNFRSF11A, TNFSF11
cell motility (GO:0048870) 3.022TNFRSF11A, TNFSF11
protein metabolic process (GO:0019538) 1.452TCIRG1, TNFSF11
immune system process (GO:0002376) 2.292TNFRSF11A, TNFSF11
positive regulation of icosanoid secretion (GO:0032305) 6.92TNFRSF11A, TNFSF11
regulation of prostaglandin secretion (GO:0032306) 7.162TNFRSF11A, TNFSF11
regulation of icosanoid secretion (GO:0032303) 6.732TNFRSF11A, TNFSF11
positive regulation of prostaglandin secretion (GO:0032308) 7.242TNFRSF11A, TNFSF11
positive regulation of anion transport (GO:1903793) 6.232TNFRSF11A, TNFSF11
positive regulation of metabolic process (GO:0009893) 1.742TNFRSF11A, TNFSF11
positive regulation of kinase activity (GO:0033674) 3.542TNFRSF11A, TNFSF11
movement of cell or subcellular component (GO:0006928) 2.612TNFRSF11A, TNFSF11
regulation of JNK cascade (GO:0046328) 4.652TNFRSF11A, TNFSF11
intracellular signal transduction (GO:0035556) 2.392PLEKHM1, TNFSF11
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582TNFRSF11A, TNFSF11
regulation of myeloid leukocyte differentiation (GO:0002761) 5.022CA2, TNFSF11
cellular protein metabolic process (GO:0044267) 1.632TCIRG1, TNFSF11
positive regulation of myeloid leukocyte differentiation (GO:0002763) 5.822CA2, TNFSF11
positive regulation of transferase activity (GO:0051347) 3.312TNFRSF11A, TNFSF11
cellular macromolecule metabolic process (GO:0044260) 0.932TCIRG1, TNFSF11
regulation of pH (GO:0006885) 5.242CA2, TCIRG1
regulation of kinase activity (GO:0043549) 3.072TNFRSF11A, TNFSF11
macromolecular complex assembly (GO:0065003) 2.552TCIRG1, TNFSF11
positive regulation of bone remodeling (GO:0046852) 7.162CA2, TNFSF11
positive regulation of immune system process (GO:0002684) 2.962CA2, TNFSF11
regulation of bone remodeling (GO:0046850) 5.942CA2, TNFSF11
regulation of immune system process (GO:0002682) 2.52CA2, TNFSF11
regulation of transmembrane transport (GO:0034762) 3.742CA2, CLCN7
inorganic ion transmembrane transport (GO:0098660) 3.382TCIRG1, CLCN7
regulation of molecular function (GO:0065009) 1.782TNFRSF11A, TNFSF11
cell migration (GO:0016477) 3.122TNFRSF11A, TNFSF11
organ morphogenesis (GO:0009887) 3.552CA2, TNFSF11
regulation of developmental process (GO:0050793) 2.12CA2, TNFSF11
regulation of catalytic activity (GO:0050790) 1.972TNFRSF11A, TNFSF11
regulation of biosynthetic process (GO:0009889) 1.372TNFRSF11A, TNFSF11
positive regulation of MAPK cascade (GO:0043410) 3.572TNFRSF11A, TNFSF11
immune response (GO:0006955) 2.862TNFRSF11A, TNFSF11
response to pH (GO:0009268) 5.972CA2, CLCN7
regulation of intracellular signal transduction (GO:1902531) 2.312TNFRSF11A, TNFSF11
positive regulation of macromolecule metabolic process (GO:0010604) 1.812TNFRSF11A, TNFSF11
positive regulation of cell differentiation (GO:0045597) 3.012CA2, TNFSF11
defense response (GO:0006952) 2.782TNFRSF11A, TCIRG1
positive regulation of protein kinase activity (GO:0045860) 3.612TNFRSF11A, TNFSF11
regulation of lipid transport (GO:0032368) 5.212TNFRSF11A, TNFSF11
regulation of response to stress (GO:0080134) 2.532TNFRSF11A, TNFSF11
positive regulation of protein modification process (GO:0031401) 2.72TNFRSF11A, TNFSF11
regulation of transferase activity (GO:0051338) 2.882TNFRSF11A, TNFSF11
regulation of transcription, DNA-templated (GO:0006355) 1.562TNFRSF11A, TNFSF11
regulation of macromolecule biosynthetic process (GO:0010556) 1.432TNFRSF11A, TNFSF11
regulation of myeloid cell differentiation (GO:0045637) 4.562CA2, TNFSF11
monovalent inorganic cation homeostasis (GO:0055067) 4.932CA2, TCIRG1
positive regulation of response to external stimulus (GO:0032103) 4.172TNFRSF11A, TNFSF11
regulation of response to external stimulus (GO:0032101) 3.062TNFRSF11A, TNFSF11
tumor necrosis factor-mediated signaling pathway (GO:0033209) 4.962TNFRSF11A, TNFSF11
positive regulation of lipid transport (GO:0032370) 5.822TNFRSF11A, TNFSF11
positive regulation of MAP kinase activity (GO:0043406) 4.392TNFRSF11A, TNFSF11
regulation of MAP kinase activity (GO:0043405) 3.952TNFRSF11A, TNFSF11
signaling (GO:0023052) 3.252TNFRSF11A, TNFSF11
positive regulation of intracellular signal transduction (GO:1902533) 2.952TNFRSF11A, TNFSF11
regulation of intracellular pH (GO:0051453) 5.442CA2, TCIRG1
anatomical structure morphogenesis (GO:0009653) 2.532CA2, TNFSF11
positive regulation of catalytic activity (GO:0043085) 2.42TNFRSF11A, TNFSF11
regulation of MAPK cascade (GO:0043408) 3.222TNFRSF11A, TNFSF11
positive regulation of heat generation (GO:0031652) 7.162TNFRSF11A, TNFSF11
regulation of heat generation (GO:0031650) 7.022TNFRSF11A, TNFSF11
positive regulation of phosphorus metabolic process (GO:0010562) 2.782TNFRSF11A, TNFSF11
regulation of protein metabolic process (GO:0051246) 1.932TNFRSF11A, TNFSF11
positive regulation of protein metabolic process (GO:0051247) 2.432TNFRSF11A, TNFSF11
positive regulation of cellular protein metabolic process (GO:0032270) 2.492TNFRSF11A, TNFSF11
regulation of protein modification process (GO:0031399) 2.322TNFRSF11A, TNFSF11
positive regulation of cell proliferation (GO:0008284) 3.012TNFRSF11A, TCIRG1
multicellular organismal process (GO:0032501) 1.452TNFRSF11A, TNFSF11
positive regulation of fatty acid transport (GO:2000193) 6.92TNFRSF11A, TNFSF11
primary metabolic process (GO:0044238) 0.692TCIRG1, TNFSF11
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442TNFRSF11A, TNFSF11
cellular ion homeostasis (GO:0006873) 3.572CA2, TCIRG1
positive regulation of ion transport (GO:0043270) 4.362TNFRSF11A, TNFSF11
cellular monovalent inorganic cation homeostasis (GO:0030004) 5.192CA2, TCIRG1
regulation of cell differentiation (GO:0045595) 2.422CA2, TNFSF11
regulation of nucleic acid-templated transcription (GO:1903506) 1.552TNFRSF11A, TNFSF11
positive regulation of stress-activated MAPK cascade (GO:0032874) 4.822TNFRSF11A, TNFSF11
mammary gland alveolus development (GO:0060749) 6.962TNFRSF11A, TNFSF11
monocyte chemotaxis (GO:0002548) 6.042TNFRSF11A, TNFSF11
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292TNFRSF11A, TNFSF11
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832TNFRSF11A, TNFSF11
positive regulation of fever generation (GO:0031622) 7.432TNFRSF11A, TNFSF11
regulation of cellular protein metabolic process (GO:0032268) 1.992TNFRSF11A, TNFSF11
regulation of fever generation (GO:0031620) 7.332TNFRSF11A, TNFSF11
positive regulation of developmental process (GO:0051094) 2.772CA2, TNFSF11
regulation of RNA metabolic process (GO:0051252) 1.522TNFRSF11A, TNFSF11
macromolecule metabolic process (GO:0043170) 0.832TCIRG1, TNFSF11
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562TNFRSF11A, TNFSF11
myeloid leukocyte migration (GO:0097529) 5.132TNFRSF11A, TNFSF11
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232TNFRSF11A, TNFSF11
cellular cation homeostasis (GO:0030003) 3.62CA2, TCIRG1
cellular homeostasis (GO:0019725) 3.232CA2, TCIRG1
regulation of cellular response to stress (GO:0080135) 3.42TNFRSF11A, TNFSF11
macromolecular complex subunit organization (GO:0043933) 2.142TCIRG1, TNFSF11
regulation of cellular biosynthetic process (GO:0031326) 1.382TNFRSF11A, TNFSF11
positive regulation of cellular metabolic process (GO:0031325) 1.812TNFRSF11A, TNFSF11
regulation of cellular metabolic process (GO:0031323) 1.072TNFRSF11A, TNFSF11
leukocyte migration (GO:0050900) 4.192TNFRSF11A, TNFSF11
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062TNFRSF11A, TNFSF11
regulation of JUN kinase activity (GO:0043506) 5.332TNFRSF11A, TNFSF11
positive regulation of JUN kinase activity (GO:0043507) 5.592TNFRSF11A, TNFSF11
multicellular organism development (GO:0007275) 2.542TNFRSF11A, TNFSF11
regulation of cellular pH (GO:0030641) 5.412CA2, TCIRG1
protein complex subunit organization (GO:0071822) 2.62TCIRG1, TNFSF11
response to lipid (GO:0033993) 3.112CA2, TNFRSF11A
regulation of nitrogen compound metabolic process (GO:0051171) 1.362TNFRSF11A, TNFSF11
regulation of fatty acid transport (GO:2000191) 6.472TNFRSF11A, TNFSF11
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462TNFRSF11A, TNFSF11
regulation of leukocyte differentiation (GO:1902105) 4.262CA2, TNFSF11
organic substance metabolic process (GO:0071704) 0.632TCIRG1, TNFSF11
positive regulation of myeloid cell differentiation (GO:0045639) 5.332CA2, TNFSF11
positive regulation of osteoclast differentiation (GO:0045672) 6.552CA2, TNFSF11
regulation of gene expression (GO:0010468) 1.372TNFRSF11A, TNFSF11
cell communication (GO:0007154) 3.042TNFRSF11A, TNFSF11
regulation of tissue remodeling (GO:0034103) 5.552CA2, TNFSF11
positive regulation of tissue remodeling (GO:0034105) 6.472CA2, TNFSF11
positive regulation of phosphate metabolic process (GO:0045937) 2.782TNFRSF11A, TNFSF11
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432TNFRSF11A, TNFSF11
autophagy (GO:0006914) 3.822PLEKHM1, TCIRG1
protein complex assembly (GO:0006461) 2.782TCIRG1, TNFSF11
regulation of phosphorus metabolic process (GO:0051174) 2.352TNFRSF11A, TNFSF11
single-organism transport (GO:0044765) 2.182CA2, TCIRG1
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) 4.822TNFRSF11A, TNFSF11
cell-cell signaling (GO:0007267) 3.352TNFRSF11A, TNFSF11
response to chemical (GO:0042221) 1.982CA2, TNFRSF11A
single-organism localization (GO:1902578) 2.092CA2, TCIRG1
locomotion (GO:0040011) 2.912TNFRSF11A, TNFSF11
regulation of stress-activated MAPK cascade (GO:0032872) 4.452TNFRSF11A, TNFSF11
positive regulation of hemopoiesis (GO:1903708) 4.632CA2, TNFSF11
regulation of bone resorption (GO:0045124) 6.22CA2, TNFSF11
positive regulation of leukocyte differentiation (GO:1902107) 4.852CA2, TNFSF11
phosphate-containing compound metabolic process (GO:0006796) 2.162TCIRG1, TNFSF11
regulation of multicellular organismal development (GO:2000026) 2.312CA2, TNFSF11
regulation of osteoclast differentiation (GO:0045670) 5.592CA2, TNFSF11
phosphorus metabolic process (GO:0006793) 2.152TCIRG1, TNFSF11
regulation of protein phosphorylation (GO:0001932) 2.572TNFRSF11A, TNFSF11
positive regulation of protein phosphorylation (GO:0001934) 2.952TNFRSF11A, TNFSF11

NET-GE enrichment

Term New enriched termICP valueGenes
tumor necrosis factor-mediated signaling pathway (GO:0033209) -4.960.029TNFRSF11A, TNFSF11
positive regulation of homeostatic process (GO:0032846) -4.380.002CA2, TNFRSF11A, TNFSF11
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling (GO:0071848) -9.040.0TNFRSF11A, TNFSF11
TNFSF11-mediated signaling pathway (GO:0071847) -8.340.0TNFRSF11A, TNFSF11
regulation of anion transport (GO:0044070) -5.250.0CA2, TNFRSF11A, CLCN7, TNFSF11
regulation of ion transport (GO:0043269) -3.40.015CA2, TNFRSF11A, CLCN7, TNFSF11
positive regulation of fatty acid transport (GO:2000193) -6.90.043TNFRSF11A, TNFSF11
positive regulation of heat generation (GO:0031652) -7.160.01TNFRSF11A, TNFSF11
positive regulation of bone resorption (GO:0045780) -7.160.036CA2, TNFSF11
regulation of heat generation (GO:0031650) -7.020.025TNFRSF11A, TNFSF11
regulation of icosanoid secretion (GO:0032303) -6.730.007TNFRSF11A, TNFSF11
myeloid leukocyte differentiation (GO:0002573) -5.230.0TNFRSF11A, SNX10, OSTM1, TNFSF11
positive regulation of bone remodeling (GO:0046852) -7.160.036CA2, TNFSF11
positive regulation of acute inflammatory response (GO:0002675) -6.360.018TNFRSF11A, TNFSF11
monocyte chemotaxis (GO:0002548) -6.040.009TNFRSF11A, TNFSF11
positive regulation of tissue remodeling (GO:0034105) -6.470.022CA2, TNFSF11
regulation of fatty acid transport (GO:2000191) -6.470.017TNFRSF11A, TNFSF11
osteoclast differentiation (GO:0030316) -6.510.0TNFRSF11A, SNX10, OSTM1, TNFSF11
response to pH (GO:0009268) -5.970.027CA2, CLCN7
mammary gland alveolus development (GO:0060749) -6.960.04TNFRSF11A, TNFSF11
leukocyte differentiation (GO:0002521) -4.130.001TNFRSF11A, SNX10, OSTM1, TNFSF11
positive regulation of fever generation by positive regulation of prostaglandin secretion (GO:0071812) -9.040.0TNFRSF11A, TNFSF11
positive regulation of fever generation (GO:0031622) -7.430.001TNFRSF11A, TNFSF11
regulation of fever generation (GO:0031620) -7.330.002TNFRSF11A, TNFSF11
regulation of bone resorption (GO:0045124) -6.20.037CA2, TNFSF11
positive regulation of icosanoid secretion (GO:0032305) -6.90.004TNFRSF11A, TNFSF11
regulation of prostaglandin secretion (GO:0032306) -7.160.019TNFRSF11A, TNFSF11
positive regulation of osteoclast differentiation (GO:0045672) -6.550.013CA2, TNFSF11
myeloid cell differentiation (GO:0030099) -4.630.0TNFRSF11A, SNX10, OSTM1, TNFSF11
positive regulation of prostaglandin secretion (GO:0032308) -7.240.018TNFRSF11A, TNFSF11
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.688CA2, PLEKHM1, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11, CLCN7
cell part (GO:0044464) 0.118CA2, PLEKHM1, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11, CLCN7
intracellular part (GO:0044424) 0.287CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, TNFSF11, CLCN7
membrane part (GO:0044425) 0.957CA2, TNFRSF11A, OSTM1, TCIRG1, SNX10, TNFSF11, CLCN7
cytoplasmic part (GO:0044444) 0.826CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
membrane-bounded organelle (GO:0043227) 0.476CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
organelle (GO:0043226) 0.46CA2, PLEKHM1, OSTM1, TCIRG1, SNX10, CLCN7
cytoplasm (GO:0005737) 1.015PLEKHM1, SNX10, CA2, OSTM1, TNFSF11
organelle membrane (GO:0031090) 1.975PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
integral component of membrane (GO:0016021) 1.145TNFRSF11A, TCIRG1, OSTM1, CLCN7, TNFSF11
vacuolar membrane (GO:0005774) 3.455PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
intracellular organelle part (GO:0044446) 0.815PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
intracellular organelle (GO:0043229) 0.515PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
vacuolar part (GO:0044437) 3.265PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
organelle part (GO:0044422) 0.795PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
whole membrane (GO:0098805) 2.855PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
bounding membrane of organelle (GO:0098588) 2.395PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
intrinsic component of membrane (GO:0031224) 1.135TNFRSF11A, TCIRG1, OSTM1, CLCN7, TNFSF11
intracellular membrane-bounded organelle (GO:0043231) 0.65PLEKHM1, SNX10, TCIRG1, OSTM1, CLCN7
vacuole (GO:0005773) 2.924PLEKHM1, SNX10, OSTM1, CLCN7
lysosomal membrane (GO:0005765) 4.194PLEKHM1, TCIRG1, OSTM1, CLCN7
plasma membrane part (GO:0044459) 1.954CA2, TNFRSF11A, TCIRG1, TNFSF11
lytic vacuole membrane (GO:0098852) 4.194PLEKHM1, TCIRG1, OSTM1, CLCN7
plasma membrane (GO:0005886) 1.394CA2, TNFRSF11A, TCIRG1, TNFSF11
lytic vacuole (GO:0000323) 3.893PLEKHM1, OSTM1, CLCN7
integral component of plasma membrane (GO:0005887) 2.573TNFRSF11A, TCIRG1, TNFSF11
lysosome (GO:0005764) 3.893PLEKHM1, OSTM1, CLCN7
endosomal part (GO:0044440) 3.733PLEKHM1, TCIRG1, SNX10
intrinsic component of plasma membrane (GO:0031226) 2.533TNFRSF11A, TCIRG1, TNFSF11
endosome membrane (GO:0010008) 3.833PLEKHM1, TCIRG1, SNX10
plasma membrane region (GO:0098590) 2.972CA2, TCIRG1
extracellular space (GO:0005615) 2.632CA2, TNFSF11
extracellular region part (GO:0044421) 1.572CA2, TNFSF11
nucleus (GO:0005634) 1.072SNX10, OSTM1
intracellular (GO:0005622) 2.372PLEKHM1, TNFSF11
endosome (GO:0005768) 3.252PLEKHM1, SNX10
cytosol (GO:0005829) 1.682CA2, OSTM1
vesicle (GO:0031982) 1.642CA2, CLCN7

NET-GE enrichment

Term New enriched termICP valueGenes
lysosomal membrane (GO:0005765) -4.190.008TCIRG1, OSTM1, CLCN7
vacuolar part (GO:0044437) -3.260.021TCIRG1, OSTM1, CLCN7
vacuolar membrane (GO:0005774) -3.450.01TCIRG1, OSTM1, CLCN7