| Disease ID | Disease name | Source of annotation with TPH2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613003 | ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | TPH2 |
| 608516 | MAJOR DEPRESSIVE DISORDER | OMIM | link to OMIM | 4 | FKBP5, TPH2, APOE, HTR2A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Metabolic pathways | hsa01100 | 2.49 |
| Tryptophan metabolism | hsa00380 | 7.34 |
| Serotonergic synapse | hsa04726 | 5.84 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Metabolism of amino acids and derivatives | R-HSA-71291 | 5.4 |
| Serotonin and melatonin biosynthesis | R-HSA-209931 | 10.66 |
| Amine-derived hormones | R-HSA-209776 | 8.98 |
| Metabolism | R-HSA-1430728 | 2.34 |
| GO term | GO ID | GO IC |
|---|---|---|
| tryptophan 5-monooxygenase activity | GO:0004510 | 9.05 |
| anion binding | GO:0043168 | 4.17 |
| monooxygenase activity | GO:0004497 | 5.1 |
| transition metal ion binding | GO:0046914 | 2.48 |
| cation binding | GO:0043169 | 1.4 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | GO:0016714 | 7.79 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | GO:0016705 | 4.65 |
| carboxylic acid binding | GO:0031406 | 4.64 |
| ion binding | GO:0043167 | 1.36 |
| catalytic activity | GO:0003824 | 1.05 |
| binding | GO:0005488 | 0.18 |
| iron ion binding | GO:0005506 | 4.65 |
| metal ion binding | GO:0046872 | 1.41 |
| amino acid binding | GO:0016597 | 5.71 |
| oxidoreductase activity | GO:0016491 | 3.12 |