Disease table of MAJOR DEPRESSIVE DISORDER OMIM ID: 608516

Gene-disease associations table

GeneAssociated with MAJOR DEPRESSIVE DISORDER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FKBP5OMIMHGNC link6p21.311608516
TPH2OMIMHGNC link12q21.12613003, 608516
APOEClinVarHGNC link19q13.325PS603075, 608516, 104310, 611771, 269600
HTR2AOMIMHGNC link13q14.25103780, 181500, 608516, 164230, 606788

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FKBP5YES1AR0
TPH2YES1REST0
APOEYES4SP1, ATF4, NR1H3, FOXM10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FKBP5APOENo1CDC37

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Serotonergic synapsehsa047265.842HTR2A, TPH2

NET-GE enrichment

Term New enriched termICP valueGenes
Serotonergic synapse (hsa04726) -5.840.043HTR2A, TPH2
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.342APOE, TPH2
Signal TransductionR-HSA-1625821.782HTR2A, APOE
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184FKBP5, HTR2A, APOE, TPH2
organic cyclic compound binding (GO:0097159) 1.053FKBP5, HTR2A, APOE
protein binding (GO:0005515) 0.463FKBP5, HTR2A, APOE
cation binding (GO:0043169) 1.42APOE, TPH2
ion binding (GO:0043167) 1.362APOE, TPH2
drug binding (GO:0008144) 5.032FKBP5, HTR2A
catalytic activity (GO:0003824) 1.052FKBP5, TPH2
macromolecular complex binding (GO:0044877) 2.612HTR2A, APOE
metal ion binding (GO:0046872) 1.412APOE, TPH2
heterocyclic compound binding (GO:1901363) 1.062FKBP5, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
drug binding (GO:0008144) -5.030.002FKBP5, HTR2A, APOE
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.264FKBP5, HTR2A, APOE, TPH2
response to external stimulus (GO:0009605) 2.553HTR2A, APOE, TPH2
response to stimulus (GO:0050896) 1.223HTR2A, APOE, TPH2
cellular metabolic process (GO:0044237) 0.693FKBP5, APOE, TPH2
organic substance metabolic process (GO:0071704) 0.633FKBP5, APOE, TPH2
single-organism cellular process (GO:0044763) 0.653HTR2A, APOE, TPH2
metabolic process (GO:0008152) 0.583FKBP5, APOE, TPH2
response to chemical (GO:0042221) 1.983HTR2A, APOE, TPH2
single-organism process (GO:0044699) 0.483HTR2A, APOE, TPH2
protein localization (GO:0008104) 2.362HTR2A, APOE
regulation of phosphate metabolic process (GO:0019220) 2.352HTR2A, APOE
regulation of primary metabolic process (GO:0080090) 1.082HTR2A, APOE
regulation of metabolic process (GO:0019222) 1.022HTR2A, APOE
regulation of transport (GO:0051049) 2.242HTR2A, APOE
regulation of response to stimulus (GO:0048583) 1.542HTR2A, APOE
circulatory system process (GO:0003013) 4.382HTR2A, APOE
signal transduction (GO:0007165) 1.282HTR2A, APOE
inorganic ion homeostasis (GO:0098771) 3.432HTR2A, APOE
positive regulation of nucleotide metabolic process (GO:0045981) 4.852HTR2A, APOE
organic cyclic compound metabolic process (GO:1901360) 1.262APOE, TPH2
cellular response to stimulus (GO:0051716) 1.972APOE, TPH2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812HTR2A, APOE
cellular macromolecule localization (GO:0070727) 3.12HTR2A, APOE
regulation of signal transduction (GO:0009966) 1.842HTR2A, APOE
calcium ion homeostasis (GO:0055074) 3.972HTR2A, APOE
interspecies interaction between organisms (GO:0044419) 3.082HTR2A, APOE
positive regulation of lipid metabolic process (GO:0045834) 4.882HTR2A, APOE
positive regulation of molecular function (GO:0044093) 2.232HTR2A, APOE
positive regulation of biological process (GO:0048518) 1.22HTR2A, APOE
negative regulation of biological process (GO:0048519) 1.332HTR2A, APOE
macromolecule localization (GO:0033036) 2.342HTR2A, APOE
regulation of cell proliferation (GO:0042127) 2.412HTR2A, APOE
negative regulation of transport (GO:0051051) 3.62HTR2A, APOE
regulation of macromolecule metabolic process (GO:0060255) 1.082HTR2A, APOE
regulation of protein kinase activity (GO:0045859) 3.152HTR2A, APOE
system process (GO:0003008) 2.32HTR2A, APOE
regulation of phosphorylation (GO:0042325) 2.52HTR2A, APOE
single organism signaling (GO:0044700) 3.252HTR2A, APOE
single-multicellular organism process (GO:0044707) 1.782HTR2A, APOE
cellular biosynthetic process (GO:0044249) 1.372APOE, TPH2
response to nutrient levels (GO:0031667) 3.772APOE, TPH2
chemical homeostasis (GO:0048878) 2.972HTR2A, APOE
anterograde trans-synaptic signaling (GO:0098916) 3.982HTR2A, APOE
regulation of protein phosphorylation (GO:0001932) 2.572HTR2A, APOE
small molecule metabolic process (GO:0044281) 2.382APOE, TPH2
positive regulation of catabolic process (GO:0009896) 3.942HTR2A, APOE
regulation of catabolic process (GO:0009894) 3.522HTR2A, APOE
positive regulation of metabolic process (GO:0009893) 1.742HTR2A, APOE
positive regulation of biosynthetic process (GO:0009891) 2.292HTR2A, APOE
vascular process in circulatory system (GO:0003018) 4.652HTR2A, APOE
intracellular signal transduction (GO:0035556) 2.392HTR2A, APOE
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582HTR2A, APOE
regulation of biological process (GO:0050789) 0.452HTR2A, APOE
organic substance biosynthetic process (GO:1901576) 1.342APOE, TPH2
cellular macromolecule metabolic process (GO:0044260) 0.932FKBP5, APOE
regulation of kinase activity (GO:0043549) 3.072HTR2A, APOE
regulation of anatomical structure size (GO:0090066) 3.782HTR2A, APOE
biological regulation (GO:0065007) 0.392HTR2A, APOE
regulation of molecular function (GO:0065009) 1.782HTR2A, APOE
regulation of biological quality (GO:0065008) 1.682HTR2A, APOE
G-protein coupled receptor signaling pathway (GO:0007186) 2.642HTR2A, APOE
regulation of tube size (GO:0035150) 4.792HTR2A, APOE
regulation of catalytic activity (GO:0050790) 1.972HTR2A, APOE
ion transport (GO:0006811) 2.662HTR2A, APOE
transport (GO:0006810) 1.512HTR2A, APOE
regulation of biosynthetic process (GO:0009889) 1.372HTR2A, APOE
single-organism metabolic process (GO:0044710) 1.632APOE, TPH2
regulation of cellular process (GO:0050794) 0.52HTR2A, APOE
regulation of blood vessel size (GO:0050880) 4.82HTR2A, APOE
regulation of multicellular organismal process (GO:0051239) 1.872HTR2A, APOE
regulation of intracellular signal transduction (GO:1902531) 2.312HTR2A, APOE
regulation of phosphorus metabolic process (GO:0051174) 2.352HTR2A, APOE
biosynthetic process (GO:0009058) 1.322APOE, TPH2
regulation of transferase activity (GO:0051338) 2.882HTR2A, APOE
positive regulation of phosphorus metabolic process (GO:0010562) 2.782HTR2A, APOE
synaptic signaling (GO:0099536) 3.982HTR2A, APOE
organic hydroxy compound metabolic process (GO:1901615) 3.842APOE, TPH2
regulation of nucleotide metabolic process (GO:0006140) 4.382HTR2A, APOE
ion homeostasis (GO:0050801) 3.422HTR2A, APOE
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292HTR2A, APOE
modulation of synaptic transmission (GO:0050804) 4.092HTR2A, APOE
negative regulation of signaling (GO:0023057) 2.652HTR2A, APOE
regulation of MAP kinase activity (GO:0043405) 3.952HTR2A, APOE
signaling (GO:0023052) 3.252HTR2A, APOE
negative regulation of cell communication (GO:0010648) 2.662HTR2A, APOE
regulation of signaling (GO:0023051) 1.722HTR2A, APOE
regulation of cell communication (GO:0010646) 1.732HTR2A, APOE
positive regulation of catalytic activity (GO:0043085) 2.42HTR2A, APOE
regulation of MAPK cascade (GO:0043408) 3.222HTR2A, APOE
divalent inorganic cation homeostasis (GO:0072507) 3.92HTR2A, APOE
establishment of localization (GO:0051234) 1.482HTR2A, APOE
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962HTR2A, APOE
establishment of localization in cell (GO:0051649) 2.472HTR2A, APOE
positive regulation of multicellular organismal process (GO:0051240) 2.492HTR2A, APOE
regulation of protein metabolic process (GO:0051246) 1.932HTR2A, APOE
positive regulation of protein metabolic process (GO:0051247) 2.432HTR2A, APOE
positive regulation of cellular protein metabolic process (GO:0032270) 2.492HTR2A, APOE
regulation of protein modification process (GO:0031399) 2.322HTR2A, APOE
developmental process (GO:0032502) 1.362HTR2A, APOE
multicellular organismal process (GO:0032501) 1.452HTR2A, APOE
cellular metal ion homeostasis (GO:0006875) 3.752HTR2A, APOE
positive regulation of cellular catabolic process (GO:0031331) 4.152HTR2A, APOE
cellular ion homeostasis (GO:0006873) 3.572HTR2A, APOE
positive regulation of cell differentiation (GO:0045597) 3.012HTR2A, APOE
regulation of cell differentiation (GO:0045595) 2.422HTR2A, APOE
cellular cation homeostasis (GO:0030003) 3.62HTR2A, APOE
cation homeostasis (GO:0055080) 3.462HTR2A, APOE
positive regulation of lipid biosynthetic process (GO:0046889) 5.552HTR2A, APOE
cellular chemical homeostasis (GO:0055082) 3.42HTR2A, APOE
regulation of localization (GO:0032879) 1.942HTR2A, APOE
regulation of cellular protein metabolic process (GO:0032268) 1.992HTR2A, APOE
macromolecule metabolic process (GO:0043170) 0.832FKBP5, APOE
cellular homeostasis (GO:0019725) 3.232HTR2A, APOE
response to extracellular stimulus (GO:0009991) 3.712APOE, TPH2
regulation of cellular catabolic process (GO:0031329) 3.832HTR2A, APOE
positive regulation of cellular biosynthetic process (GO:0031328) 2.32HTR2A, APOE
regulation of cellular biosynthetic process (GO:0031326) 1.382HTR2A, APOE
positive regulation of cellular metabolic process (GO:0031325) 1.812HTR2A, APOE
regulation of cellular metabolic process (GO:0031323) 1.072HTR2A, APOE
homeostatic process (GO:0042592) 2.612HTR2A, APOE
regulation of lipid biosynthetic process (GO:0046890) 4.872HTR2A, APOE
cellular calcium ion homeostasis (GO:0006874) 4.012HTR2A, APOE
multi-organism process (GO:0051704) 2.652HTR2A, APOE
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352HTR2A, APOE
positive regulation of phosphate metabolic process (GO:0045937) 2.782HTR2A, APOE
regulation of lipid metabolic process (GO:0019216) 4.082HTR2A, APOE
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432HTR2A, APOE
cellular protein localization (GO:0034613) 3.112HTR2A, APOE
single-organism developmental process (GO:0044767) 1.492HTR2A, APOE
single-organism transport (GO:0044765) 2.182HTR2A, APOE
multi-organism cellular process (GO:0044764) 3.142HTR2A, APOE
regulation of nitrogen compound metabolic process (GO:0051171) 1.362HTR2A, APOE
chemical synaptic transmission (GO:0007268) 3.982HTR2A, APOE
metal ion homeostasis (GO:0055065) 3.612HTR2A, APOE
cell-cell signaling (GO:0007267) 3.352HTR2A, APOE
cell communication (GO:0007154) 3.042HTR2A, APOE
localization (GO:0051179) 1.42HTR2A, APOE
single-organism localization (GO:1902578) 2.092HTR2A, APOE
cellular localization (GO:0051641) 2.322HTR2A, APOE
primary metabolic process (GO:0044238) 0.692FKBP5, APOE
regulation of purine nucleotide metabolic process (GO:1900542) 4.412HTR2A, APOE
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.852HTR2A, APOE
viral process (GO:0016032) 3.152HTR2A, APOE
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152HTR2A, APOE
trans-synaptic signaling (GO:0099537) 3.982HTR2A, APOE
negative regulation of cellular process (GO:0048523) 1.412HTR2A, APOE
positive regulation of cellular process (GO:0048522) 1.32HTR2A, APOE

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of tube size (GO:0035150) -4.790.048HTR2A, APOE
positive regulation of lipid biosynthetic process (GO:0046889) -5.550.03HTR2A, APOE
positive regulation of dendritic spine development (GO:0060999) NEW6.170.042HTR2A, APOE
regulation of blood vessel size (GO:0050880) -4.80.047HTR2A, APOE
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.284FKBP5, HTR2A, APOE, TPH2
cytoplasmic part (GO:0044444) 0.824FKBP5, HTR2A, APOE, TPH2
cell part (GO:0044464) 0.114FKBP5, HTR2A, APOE, TPH2
cytoplasm (GO:0005737) 1.013FKBP5, HTR2A, APOE
vesicle (GO:0031982) 1.643FKBP5, HTR2A, APOE
membrane (GO:0016020) 0.683FKBP5, HTR2A, APOE
membrane-bounded vesicle (GO:0031988) 1.713FKBP5, HTR2A, APOE
neuron part (GO:0097458) 2.643HTR2A, APOE, TPH2
intracellular organelle (GO:0043229) 0.513FKBP5, HTR2A, APOE
neuron projection (GO:0043005) 3.123HTR2A, APOE, TPH2
cell projection (GO:0042995) 2.473HTR2A, APOE, TPH2
membrane-bounded organelle (GO:0043227) 0.473FKBP5, HTR2A, APOE
organelle (GO:0043226) 0.43FKBP5, HTR2A, APOE
intracellular membrane-bounded organelle (GO:0043231) 0.63FKBP5, HTR2A, APOE
extracellular organelle (GO:0043230) 1.892FKBP5, APOE
extracellular exosome (GO:0070062) 1.892FKBP5, APOE
nucleus (GO:0005634) 1.072FKBP5, APOE
cell body (GO:0044297) 3.742HTR2A, APOE
dendrite (GO:0030425) 3.922HTR2A, APOE
extracellular region part (GO:0044421) 1.572FKBP5, APOE
intracellular organelle part (GO:0044446) 0.812FKBP5, APOE
plasma membrane (GO:0005886) 1.392HTR2A, APOE
membrane part (GO:0044425) 0.952FKBP5, HTR2A
extracellular vesicle (GO:1903561) 1.892FKBP5, APOE
neuronal cell body (GO:0043025) 3.92HTR2A, APOE
cytosol (GO:0005829) 1.682HTR2A, TPH2
organelle part (GO:0044422) 0.792FKBP5, APOE

NET-GE enrichment

Term New enriched termICP valueGenes
neuron part (GO:0097458) -2.640.031HTR2A, APOE, TPH2
neuron projection (GO:0043005) -3.120.008HTR2A, APOE, TPH2