Gene table of VRK1 : vaccinia related kinase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with VRK1	OMIM link	Number of associated genes	genes
PS607596	PONTOCEREBELLAR HYPOPLASIA	ClinVar, OMIM	link to OMIM	13	AMPD2, EXOSC3, CLP1, SEPSECS, TSEN34, TSEN2, PCLO, VPS53, TSEN54, KCNT1, RARS2, VRK1, CHMP1A

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Annotation of the gene VRK1

Associated genes in ENSEMBL

ENSG00000100749

Associated proteins - SwissProt Accession ID

Q99986

Associated PDB IDs

Cytogenetic Band

14q32.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.45
Initiation of Nuclear Envelope Reformation	R-HSA-2995383	9.28
M Phase	R-HSA-68886	4.87
Cell Cycle, Mitotic	R-HSA-69278	4.16
Mitotic Anaphase	R-HSA-68882	5.46
Clearance of Nuclear Envelope Membranes from Chromatin	R-HSA-2993913	9.81
Cell Cycle	R-HSA-1640170	3.89
Nuclear Envelope Reassembly	R-HSA-2995410	9.28
Nuclear Envelope Breakdown	R-HSA-2980766	7.34
Mitotic Prophase	R-HSA-68875	6.27

Associated GO terms for Molecular function

GO term	GO ID	GO IC
histone binding	GO:0042393	4.72
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
nucleosome binding	GO:0031491	5.95
nucleosomal histone binding	GO:0031493	8.64
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
histone kinase activity (H3-T3 specific)	GO:0072354	9.05
histone threonine kinase activity	GO:0035184	7.79
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
nucleoside binding	GO:0001882	2.21
ATP binding	GO:0005524	2.43
histone kinase activity (H3-S10 specific)	GO:0035175	8.64
histone serine kinase activity	GO:0035174	7.66
kinase activity	GO:0016301	2.93
histone kinase activity	GO:0035173	6.79
protein kinase binding	GO:0019901	3.44
kinase binding	GO:0019900	3.32
small molecule binding	GO:0036094	1.89
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
catalytic activity	GO:0003824	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
purine ribonucleotide binding	GO:0032555	2.2
chromatin binding	GO:0003682	3.64
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19