Disease table of PONTOCEREBELLAR HYPOPLASIA OMIM ID: PS607596

Gene-disease associations table

GeneAssociated with PONTOCEREBELLAR HYPOPLASIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TSEN34ClinVar, OMIM, HUMSAVARHGNC link19q13.421PS607596
VRK1ClinVar, OMIMHGNC link14q32.21PS607596
TSEN2ClinVar, OMIM, HUMSAVARHGNC link3p25.21PS607596
CLP1ClinVar, OMIM, HUMSAVARHGNC link11q12.11PS607596
AMPD2ClinVar, OMIM, HUMSAVARHGNC link1p13.32PS607596, PS303350
KCNT1ClinVar, OMIM, HUMSAVARHGNC link9q34.33PS600513, PS607596, PS308350
PCLOClinVar, OMIMHGNC link7q21.111PS607596
RARS2ClinVar, OMIMHGNC link6q151PS607596
TSEN54ClinVar, OMIM, HUMSAVARHGNC link17q25.11PS607596
VPS53ClinVar, OMIM, HUMSAVARHGNC link17p13.31PS607596
EXOSC3ClinVar, OMIM, HUMSAVARHGNC link9p13.21PS607596
CHMP1AClinVar, OMIMHGNC link16q24.31PS607596
SEPSECSClinVar, OMIM, HUMSAVARHGNC link4p15.21PS607596

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
172TSEN54, VPS53
92KCNT1, EXOSC3
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TSEN34TSEN2Yes3TSEN15, TSEN54, CLP1
TSEN34CLP1Yes4TSEN2, TSEN15, TSEN54, CLP1
TSEN34TSEN54Yes3TSEN2, TSEN15, CLP1
VRK1CLP1No1SNW1
VRK1VPS53No1VPS52
TSEN2CLP1Yes4TSEN54, TSEN34, TSEN15, CLP1
TSEN2TSEN54Yes4TSEN34, ZNRF1, TSEN15, CLP1
TSEN2CHMP1ANo1USP8
CLP1TSEN54Yes5TSEN2, AMMECR1, TSEN34, TSEN15, CLP1
CLP1EXOSC3No1APP
AMPD2RARS2No1NTRK1
AMPD2TSEN54No1CSNK2B
TSEN54EXOSC3No1NXF1
TSEN54CHMP1ANo2NXF1, MOV10
EXOSC3CHMP1ANo1NXF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
VRK1CLP1No-2UBC, HNRNPA1
VRK1AMPD2No-1UBC
VRK1VPS53No-1UBC
VRK1EXOSC3No-1UBC
VRK1CHMP1ANo-1UBC
TSEN2CLP1Yesbinding0
TSEN2TSEN54Yesbinding1TSEN15
CLP1AMPD2No-1UBC
CLP1TSEN54No-1TSEN2
CLP1VPS53No-1UBC
CLP1EXOSC3No-1UBC
CLP1CHMP1ANo-1UBC
AMPD2VPS53No-1UBC
AMPD2EXOSC3No-1UBC
AMPD2CHMP1ANo-1UBC
VPS53EXOSC3No-1UBC
VPS53CHMP1ANo-1UBC
EXOSC3CHMP1ANo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
TSEN34TSEN2YestRNA splicing endonuclease3TSEN15, TSEN54, CLP1
TSEN34CLP1YestRNA splicing endonuclease3TSEN2, TSEN15, TSEN54
TSEN34TSEN54YestRNA splicing endonuclease3TSEN2, TSEN15, CLP1
TSEN2CLP1YesRNA endonuclease (SEN2deltaEx8, SEN54, CLP1);tRNA splicing endonuclease3TSEN34, TSEN15, TSEN54
TSEN2TSEN54YesRNA endonuclease (SEN2deltaEx8, SEN54, CLP1);tRNA splicing endonuclease3TSEN34, TSEN15, CLP1
CLP1TSEN54YesRNA endonuclease (SEN2deltaEx8, SEN54, CLP1);tRNA splicing endonuclease3TSEN2, TSEN34, TSEN15

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Aminoacyl-tRNA biosynthesishsa009707.312SEPSECS, RARS2

NET-GE enrichment

Term New enriched termICP valueGenes
Aminoacyl-tRNA biosynthesis (hsa00970) -7.310.01SEPSECS, RARS2
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Gene ExpressionR-HSA-741602.723RARS2, EXOSC3, CLP1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1812TSEN54, VPS53, SEPSECS, RARS2, CHMP1A, PCLO, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
catalytic activity (GO:0003824) 1.0510SEPSECS, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, TSEN54, EXOSC3, TSEN2, VRK1
protein binding (GO:0005515) 0.469VPS53, SEPSECS, TSEN54, AMPD2, CHMP1A, PCLO, EXOSC3, TSEN2, VRK1
organic cyclic compound binding (GO:0097159) 1.057SEPSECS, RARS2, CLP1, TSEN34, EXOSC3, TSEN2, VRK1
heterocyclic compound binding (GO:1901363) 1.067SEPSECS, RARS2, CLP1, TSEN34, EXOSC3, TSEN2, VRK1
hydrolase activity (GO:0016787) 1.96CHMP1A, TSEN54, AMPD2, TSEN34, EXOSC3, TSEN2
nucleic acid binding (GO:0003676) 1.445SEPSECS, TSEN2, TSEN34, RARS2, EXOSC3
nuclease activity (GO:0004518) 4.334TSEN2, TSEN34, TSEN54, EXOSC3
ribonuclease activity (GO:0004540) 5.044TSEN2, TSEN34, TSEN54, EXOSC3
hydrolase activity, acting on ester bonds (GO:0016788) 3.14TSEN2, TSEN34, TSEN54, EXOSC3
purine ribonucleoside triphosphate binding (GO:0035639) 2.223RARS2, VRK1, CLP1
nucleotide binding (GO:0000166) 1.963RARS2, VRK1, CLP1
nucleoside phosphate binding (GO:1901265) 1.963RARS2, VRK1, CLP1
nucleoside binding (GO:0001882) 2.213RARS2, VRK1, CLP1
cation binding (GO:0043169) 1.43AMPD2, CHMP1A, PCLO
tRNA-specific ribonuclease activity (GO:0004549) 6.973TSEN2, TSEN34, TSEN54
endoribonuclease activity (GO:0004521) 5.583TSEN2, TSEN34, TSEN54
ion binding (GO:0043167) 1.363AMPD2, CHMP1A, PCLO
transferase activity (GO:0016740) 1.953SEPSECS, VRK1, CLP1
purine nucleoside binding (GO:0001883) 2.223RARS2, VRK1, CLP1
ribonucleoside binding (GO:0032549) 2.223RARS2, VRK1, CLP1
purine nucleotide binding (GO:0017076) 2.193RARS2, VRK1, CLP1
metal ion binding (GO:0046872) 1.413AMPD2, CHMP1A, PCLO
ATP binding (GO:0005524) 2.433RARS2, VRK1, CLP1
tRNA-intron endonuclease activity (GO:0000213) 8.353TSEN2, TSEN34, TSEN54
endoribonuclease activity, producing 3'-phosphomonoesters (GO:0016892) 7.343TSEN2, TSEN34, TSEN54
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (GO:0016894) 6.743TSEN2, TSEN34, TSEN54
small molecule binding (GO:0036094) 1.893RARS2, VRK1, CLP1
adenyl nucleotide binding (GO:0030554) 2.43RARS2, VRK1, CLP1
carbohydrate derivative binding (GO:0097367) 2.033RARS2, VRK1, CLP1
endonuclease activity (GO:0004519) 4.783TSEN2, TSEN34, TSEN54
adenyl ribonucleotide binding (GO:0032559) 2.413RARS2, VRK1, CLP1
RNA binding (GO:0003723) 2.363SEPSECS, RARS2, EXOSC3
purine ribonucleotide binding (GO:0032555) 2.23RARS2, VRK1, CLP1
purine ribonucleoside binding (GO:0032550) 2.223RARS2, VRK1, CLP1
ribonucleotide binding (GO:0032553) 2.193RARS2, VRK1, CLP1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082VRK1, CLP1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772VRK1, CLP1
lyase activity (GO:0016829) 4.532TSEN2, TSEN34
kinase activity (GO:0016301) 2.932VRK1, CLP1

NET-GE enrichment

Term New enriched termICP valueGenes
tRNA-specific ribonuclease activity (GO:0004549) -6.970.0TSEN2, TSEN34, CLP1
nuclease activity (GO:0004518) -4.330.034TSEN2, TSEN34, EXOSC3, CLP1
ribonuclease activity (GO:0004540) -5.040.002TSEN2, TSEN34, EXOSC3, CLP1
endoribonuclease activity (GO:0004521) -5.580.003TSEN2, TSEN34, CLP1
endoribonuclease activity, producing 3'-phosphomonoesters (GO:0016892) -7.340.002TSEN2, TSEN34
tRNA-intron endonuclease activity (GO:0000213) -8.350.0TSEN2, TSEN34
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters (GO:0016894) -6.740.0TSEN2, TSEN34, CLP1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2612TSEN54, SEPSECS, KCNT1, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
primary metabolic process (GO:0044238) 0.6910SEPSECS, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, TSEN54, EXOSC3, TSEN2, VRK1
cellular metabolic process (GO:0044237) 0.6910SEPSECS, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, TSEN54, EXOSC3, TSEN2, VRK1
metabolic process (GO:0008152) 0.5810SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
organic substance metabolic process (GO:0071704) 0.6310SEPSECS, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, TSEN54, EXOSC3, TSEN2, VRK1
nucleobase-containing compound metabolic process (GO:0006139) 1.359SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
cellular macromolecule metabolic process (GO:0044260) 0.939SEPSECS, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
cellular aromatic compound metabolic process (GO:0006725) 1.39SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
macromolecule metabolic process (GO:0043170) 0.839SEPSECS, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
cellular nitrogen compound metabolic process (GO:0034641) 1.229SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
nitrogen compound metabolic process (GO:0006807) 1.139SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
single-organism process (GO:0044699) 0.489SEPSECS, KCNT1, RARS2, PCLO, AMPD2, CHMP1A, CLP1, EXOSC3, VRK1
organic cyclic compound metabolic process (GO:1901360) 1.269SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
heterocycle metabolic process (GO:0046483) 1.319SEPSECS, RARS2, CHMP1A, TSEN54, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2
RNA metabolic process (GO:0016070) 1.598SEPSECS, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
nucleic acid metabolic process (GO:0090304) 1.468SEPSECS, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
single-organism cellular process (GO:0044763) 0.658SEPSECS, KCNT1, RARS2, PCLO, AMPD2, CHMP1A, EXOSC3, VRK1
ncRNA metabolic process (GO:0034660) 3.447SEPSECS, RARS2, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
tRNA metabolic process (GO:0006399) 4.527SEPSECS, RARS2, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
biological regulation (GO:0065007) 0.396SEPSECS, PCLO, AMPD2, CHMP1A, EXOSC3, VRK1
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.125TSEN2, TSEN54, TSEN34, EXOSC3, CLP1
mRNA metabolic process (GO:0016071) 3.335TSEN2, TSEN54, TSEN34, EXOSC3, CLP1
RNA phosphodiester bond hydrolysis (GO:0090501) 4.835TSEN2, TSEN34, EXOSC3, TSEN54, CLP1
ncRNA processing (GO:0034470) 3.775TSEN2, TSEN54, TSEN34, EXOSC3, CLP1
organic substance biosynthetic process (GO:1901576) 1.345AMPD2, SEPSECS, CHMP1A, RARS2, CLP1
cellular component organization (GO:0016043) 1.245PCLO, CHMP1A, RARS2, VRK1, CLP1
regulation of biological process (GO:0050789) 0.455SEPSECS, CHMP1A, EXOSC3, VRK1, PCLO
cellular biosynthetic process (GO:0044249) 1.375AMPD2, SEPSECS, CHMP1A, RARS2, CLP1
biosynthetic process (GO:0009058) 1.325AMPD2, SEPSECS, CHMP1A, RARS2, CLP1
cellular component organization or biogenesis (GO:0071840) 1.225VRK1, CHMP1A, RARS2, PCLO, CLP1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595AMPD2, SEPSECS, CHMP1A, RARS2, CLP1
regulation of cellular process (GO:0050794) 0.55SEPSECS, VRK1, CHMP1A, PCLO, EXOSC3
localization (GO:0051179) 1.45PCLO, CHMP1A, KCNT1, EXOSC3, VPS53
RNA processing (GO:0006396) 3.015TSEN2, TSEN54, TSEN34, CLP1, EXOSC3
organelle organization (GO:0006996) 2.024CHMP1A, RARS2, VRK1, PCLO
single-organism metabolic process (GO:0044710) 1.634AMPD2, SEPSECS, RARS2, EXOSC3
establishment of localization (GO:0051234) 1.484PCLO, KCNT1, CHMP1A, VPS53
tRNA processing (GO:0008033) 4.964TSEN2, TSEN34, TSEN54, CLP1
regulation of biological quality (GO:0065008) 1.684AMPD2, EXOSC3, VRK1, PCLO
mRNA processing (GO:0006397) 3.694TSEN2, TSEN34, TSEN54, CLP1
protein metabolic process (GO:0019538) 1.454SEPSECS, CHMP1A, RARS2, VRK1
transport (GO:0006810) 1.514PCLO, KCNT1, CHMP1A, VPS53
RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) 6.964TSEN2, TSEN34, TSEN54, CLP1
macromolecule biosynthetic process (GO:0009059) 1.614SEPSECS, CHMP1A, RARS2, CLP1
cellular localization (GO:0051641) 2.324PCLO, CHMP1A, EXOSC3, VPS53
tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) 7.024TSEN2, TSEN34, TSEN54, CLP1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724AMPD2, SEPSECS, CHMP1A, CLP1
aromatic compound biosynthetic process (GO:0019438) 1.74AMPD2, SEPSECS, CHMP1A, CLP1
macromolecule localization (GO:0033036) 2.344PCLO, CHMP1A, EXOSC3, VPS53
organic cyclic compound biosynthetic process (GO:1901362) 1.664AMPD2, SEPSECS, CHMP1A, CLP1
RNA splicing (GO:0008380) 3.854TSEN2, TSEN34, TSEN54, CLP1
heterocycle biosynthetic process (GO:0018130) 1.74AMPD2, SEPSECS, CHMP1A, CLP1
protein localization (GO:0008104) 2.363CHMP1A, PCLO, VPS53
regulation of primary metabolic process (GO:0080090) 1.083SEPSECS, CHMP1A, EXOSC3
regulation of metabolic process (GO:0019222) 1.023SEPSECS, CHMP1A, EXOSC3
macromolecular complex subunit organization (GO:0043933) 2.143CHMP1A, VRK1, CLP1
regulation of cellular metabolic process (GO:0031323) 1.073SEPSECS, CHMP1A, EXOSC3
cellular component assembly (GO:0022607) 2.143CHMP1A, PCLO, CLP1
small molecule metabolic process (GO:0044281) 2.383AMPD2, SEPSECS, RARS2
cellular macromolecule biosynthetic process (GO:0034645) 1.663SEPSECS, CHMP1A, RARS2
RNA biosynthetic process (GO:0032774) 1.843SEPSECS, CHMP1A, CLP1
cellular protein metabolic process (GO:0044267) 1.633SEPSECS, RARS2, VRK1
organic substance transport (GO:0071702) 2.153CHMP1A, PCLO, VPS53
regulation of gene expression (GO:0010468) 1.373SEPSECS, CHMP1A, EXOSC3
regulation of macromolecule metabolic process (GO:0060255) 1.083SEPSECS, CHMP1A, EXOSC3
establishment of protein localization (GO:0045184) 2.533CHMP1A, PCLO, VPS53
regulation of nitrogen compound metabolic process (GO:0051171) 1.363SEPSECS, CHMP1A, EXOSC3
establishment of localization in cell (GO:0051649) 2.473CHMP1A, PCLO, VPS53
tRNA-type intron splice site recognition and cleavage (GO:0000379) 8.633TSEN2, TSEN34, TSEN54
RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) 5.413TSEN2, TSEN34, TSEN54
organonitrogen compound metabolic process (GO:1901564) 2.323AMPD2, SEPSECS, RARS2
vesicle-mediated transport (GO:0016192) 2.723CHMP1A, PCLO, VPS53
organonitrogen compound biosynthetic process (GO:1901566) 2.853AMPD2, SEPSECS, RARS2
phosphate-containing compound metabolic process (GO:0006796) 2.163AMPD2, VRK1, CLP1
phosphorus metabolic process (GO:0006793) 2.153AMPD2, VRK1, CLP1
protein transport (GO:0015031) 2.623CHMP1A, PCLO, VPS53
peptide biosynthetic process (GO:0043043) 3.732SEPSECS, RARS2
mitotic cell cycle process (GO:1903047) 3.122CHMP1A, VRK1
regulation of cellular component organization (GO:0051128) 2.012CHMP1A, VRK1
membrane organization (GO:0061024) 3.042CHMP1A, VRK1
cell cycle process (GO:0022402) 2.752CHMP1A, VRK1
cell division (GO:0051301) 3.682CHMP1A, VRK1
establishment of organelle localization (GO:0051656) 4.152CHMP1A, PCLO
cell cycle (GO:0007049) 3.142CHMP1A, VRK1
posttranscriptional regulation of gene expression (GO:0010608) 3.642SEPSECS, EXOSC3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462SEPSECS, CHMP1A
regulation of developmental process (GO:0050793) 2.12VRK1, EXOSC3
organelle localization (GO:0051640) 3.942CHMP1A, PCLO
phosphorylation (GO:0016310) 2.632VRK1, CLP1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432CHMP1A, EXOSC3
regulation of biosynthetic process (GO:0009889) 1.372SEPSECS, CHMP1A
RNA 3'-end processing (GO:0031123) 5.152EXOSC3, CLP1
regulation of cellular biosynthetic process (GO:0031326) 1.382SEPSECS, CHMP1A
single-organism transport (GO:0044765) 2.182KCNT1, PCLO
cellular component disassembly (GO:0022411) 3.522CHMP1A, VRK1
single-organism localization (GO:1902578) 2.092KCNT1, PCLO
amide biosynthetic process (GO:0043604) 3.62SEPSECS, RARS2
vacuolar transport (GO:0007034) 4.182CHMP1A, VPS53
organic acid metabolic process (GO:0006082) 3.012SEPSECS, RARS2
macromolecule modification (GO:0043412) 1.732VRK1, EXOSC3
regulation of macromolecule biosynthetic process (GO:0010556) 1.432SEPSECS, CHMP1A
cellular amide metabolic process (GO:0043603) 3.232SEPSECS, RARS2
peptide metabolic process (GO:0006518) 3.442SEPSECS, RARS2
translation (GO:0006412) 3.792SEPSECS, RARS2

NET-GE enrichment

Term New enriched termICP valueGenes
RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) -5.410.024TSEN2, TSEN34, CLP1
mRNA metabolic process (GO:0016071) -3.330.015TSEN2, TSEN54, TSEN34, CLP1, EXOSC3
RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) -6.960.0TSEN2, TSEN34, TSEN54, CLP1
RNA phosphodiester bond hydrolysis (GO:0090501) -4.830.013TSEN2, TSEN34, EXOSC3, CLP1
ncRNA processing (GO:0034470) -3.770.007TSEN2, TSEN54, TSEN34, EXOSC3, CLP1
tRNA metabolic process (GO:0006399) -4.520.0SEPSECS, RARS2, TSEN54, TSEN34, CLP1, TSEN2
tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) -7.020.0TSEN2, TSEN34, TSEN54, CLP1
tRNA processing (GO:0008033) -4.960.004TSEN2, TSEN34, TSEN54, CLP1
ncRNA metabolic process (GO:0034660) -3.440.0SEPSECS, RARS2, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
RNA splicing (GO:0008380) -3.850.02TSEN2, TSEN34, TSEN54, CLP1
RNA processing (GO:0006396) -3.010.029TSEN2, TSEN54, TSEN34, CLP1, EXOSC3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1113TSEN54, VPS53, SEPSECS, KCNT1, RARS2, CHMP1A, CLP1, AMPD2, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
intracellular part (GO:0044424) 0.2812TSEN54, VPS53, SEPSECS, RARS2, CHMP1A, PCLO, AMPD2, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
intracellular organelle (GO:0043229) 0.5111VPS53, SEPSECS, RARS2, CHMP1A, PCLO, TSEN34, TSEN54, EXOSC3, TSEN2, CLP1, VRK1
membrane-bounded organelle (GO:0043227) 0.4711VPS53, SEPSECS, RARS2, CHMP1A, PCLO, TSEN34, TSEN54, EXOSC3, TSEN2, CLP1, VRK1
organelle (GO:0043226) 0.411VPS53, SEPSECS, RARS2, CHMP1A, PCLO, TSEN34, TSEN54, EXOSC3, TSEN2, CLP1, VRK1
intracellular membrane-bounded organelle (GO:0043231) 0.610VPS53, SEPSECS, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
intracellular organelle part (GO:0044446) 0.819VPS53, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
organelle part (GO:0044422) 0.799VPS53, RARS2, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
protein complex (GO:0043234) 1.518VPS53, KCNT1, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
cytoplasmic part (GO:0044444) 0.828SEPSECS, RARS2, PCLO, AMPD2, CHMP1A, VPS53, EXOSC3, VRK1
macromolecular complex (GO:0032991) 1.358VPS53, KCNT1, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2
nucleus (GO:0005634) 1.078SEPSECS, CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
cytoplasm (GO:0005737) 1.017SEPSECS, RARS2, CLP1, CHMP1A, EXOSC3, TSEN2, VRK1
non-membrane-bounded organelle (GO:0043228) 1.767CHMP1A, TSEN54, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
nuclear part (GO:0044428) 1.557CHMP1A, TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
intracellular non-membrane-bounded organelle (GO:0043232) 1.767CHMP1A, TSEN54, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
nucleoplasm (GO:0005654) 1.896TSEN54, TSEN34, CLP1, EXOSC3, TSEN2, VRK1
cytosol (GO:0005829) 1.686SEPSECS, PCLO, AMPD2, VPS53, EXOSC3, VRK1
membrane (GO:0016020) 0.685PCLO, VRK1, KCNT1, CHMP1A, VPS53
nucleolus (GO:0005730) 3.065TSEN2, TSEN34, EXOSC3, VRK1, TSEN54
membrane part (GO:0044425) 0.954PCLO, KCNT1, CHMP1A, VRK1
tRNA-intron endonuclease complex (GO:0000214) 8.424TSEN2, TSEN34, TSEN54, CLP1
catalytic complex (GO:1902494) 2.94TSEN2, TSEN34, TSEN54, CLP1
endoribonuclease complex (GO:1902555) 6.764TSEN2, TSEN34, TSEN54, CLP1
integral component of membrane (GO:0016021) 1.143KCNT1, PCLO, VRK1
cytoskeletal part (GO:0044430) 2.493TSEN2, CHMP1A, VRK1
intrinsic component of membrane (GO:0031224) 1.133KCNT1, VRK1, PCLO
cytoskeleton (GO:0005856) 2.552PCLO, VRK1
extracellular vesicle (GO:1903561) 1.892CHMP1A, PCLO
extracellular organelle (GO:0043230) 1.892CHMP1A, PCLO
vesicle (GO:0031982) 1.642CHMP1A, PCLO
vacuole (GO:0005773) 2.922CHMP1A, VPS53
extracellular exosome (GO:0070062) 1.892CHMP1A, PCLO
bounding membrane of organelle (GO:0098588) 2.392CHMP1A, VPS53
vacuolar membrane (GO:0005774) 3.452CHMP1A, VPS53
microtubule organizing center (GO:0005815) 3.422TSEN2, CHMP1A
membrane protein complex (GO:0098796) 2.842KCNT1, CHMP1A
Golgi apparatus part (GO:0044431) 3.02VRK1, VPS53
vacuolar part (GO:0044437) 3.262CHMP1A, VPS53
organelle membrane (GO:0031090) 1.972CHMP1A, VPS53
endosomal part (GO:0044440) 3.732CHMP1A, VPS53
whole membrane (GO:0098805) 2.852CHMP1A, VPS53
membrane-bounded vesicle (GO:0031988) 1.712CHMP1A, PCLO
endosome (GO:0005768) 3.252CHMP1A, VPS53
extracellular region part (GO:0044421) 1.572CHMP1A, PCLO
endosome membrane (GO:0010008) 3.832CHMP1A, VPS53

NET-GE enrichment

Term New enriched termICP valueGenes
non-membrane-bounded organelle (GO:0043228) -1.760.036CHMP1A, TSEN54, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
endoribonuclease complex (GO:1902555) -6.760.0TSEN2, TSEN34, CLP1
intracellular non-membrane-bounded organelle (GO:0043232) -1.760.036CHMP1A, TSEN54, TSEN34, PCLO, EXOSC3, TSEN2, VRK1
tRNA-intron endonuclease complex (GO:0000214) -8.420.0TSEN2, TSEN34, CLP1