Gene table of WNK1 : WNK lysine deficient protein kinase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with WNK1	OMIM link	Number of associated genes	genes
PS162400	HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY	ClinVar, OMIM	link to OMIM	14	DST, WNK1, NTRK1, PRDM12, DNMT1, IKBKAP, FAM134B, NGF, ATL1, KIF1A, SCN11A, ATL3, SPTLC2, SPTLC1
PS145260	PSEUDOHYPOALDOSTERONISM, TYPE II	OMIM	link to OMIM	4	KLHL3, WNK4, CUL3, WNK1

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Annotation of the gene WNK1

Associated genes in ENSEMBL

ENSG00000060237

Associated proteins - SwissProt Accession ID

Q9H4A3

Associated PDB IDs

4pwn

Cytogenetic Band

12p13.33

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Ion channel transport	R-HSA-983712	5.34
Transmembrane transport of small molecules	R-HSA-382551	3.79
Stimuli-sensing channels	R-HSA-2672351	6.28

Associated GO terms for Molecular function

GO term	GO ID	GO IC
kinase regulator activity	GO:0019207	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
small molecule binding	GO:0036094	1.89
binding	GO:0005488	0.18
enzyme inhibitor activity	GO:0004857	3.78
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
kinase binding	GO:0019900	3.32
potassium channel inhibitor activity	GO:0019870	7.66
magnesium ion binding	GO:0000287	4.41
ribonucleoside binding	GO:0032549	2.22
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
channel regulator activity	GO:0016247	4.88
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
potassium channel regulator activity	GO:0015459	5.93
ATP binding	GO:0005524	2.43
kinase inhibitor activity	GO:0019210	5.25
protein kinase regulator activity	GO:0019887	4.6
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
protein kinase inhibitor activity	GO:0004860	5.28
catalytic activity	GO:0003824	1.05
phosphatase binding	GO:0019902	4.63
channel inhibitor activity	GO:0016248	6.13
protein serine/threonine kinase inhibitor activity	GO:0030291	6.34
ion channel inhibitor activity	GO:0008200	6.15
protein kinase binding	GO:0019901	3.44
chloride channel inhibitor activity	GO:0019869	7.54
adenyl nucleotide binding	GO:0030554	2.4
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
organic cyclic compound binding	GO:0097159	1.05
carbohydrate derivative binding	GO:0097367	2.03
chloride channel regulator activity	GO:0017081	7.03
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19