Disease table of HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY OMIM ID: PS162400

Gene-disease associations table

GeneAssociated with HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SCN11AClinVar, OMIM, HUMSAVARHGNC link3p22.22PS162400, PS615040
NGFClinVar, OMIM, HUMSAVARHGNC link1p13.21PS162400
WNK1ClinVar, OMIMHGNC link12p13.332PS162400, PS145260
PRDM12OMIM, HUMSAVARHGNC link9q34.121PS162400
KIF1AClinVar, OMIMHGNC link2q37.33PS156200, PS303350, PS162400
DSTOMIMHGNC link6p12.12PS162400, 615425
DNMT1ClinVar, OMIM, HUMSAVARHGNC link19p13.22604121, PS162400
ATL3ClinVar, OMIM, HUMSAVARHGNC link11q13.11PS162400
NTRK1ClinVar, OMIM, HUMSAVARHGNC link1q23.12PS162400, 155240
ATL1ClinVar, OMIM, HUMSAVARHGNC link14q22.12PS162400, PS303350
IKBKAPClinVar, OMIM, HUMSAVARHGNC link9q31.31PS162400
SPTLC1ClinVar, OMIM, HUMSAVARHGNC link9q22.311PS162400
SPTLC2ClinVar, OMIM, HUMSAVARHGNC link14q24.31PS162400
FAM134BClinVar, OMIMHGNC link5p15.11PS162400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
14q22SPTLC2, ATL1
9q32PRDM12, IKBKAP
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
14q2SPTLC2, ATL1
9q3PRDM12, SPTLC1, IKBKAP
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
142SPTLC2, ATL1
12NGF, NTRK1
93PRDM12, SPTLC1, IKBKAP
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
DNMT1YES24MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH20
ING4NO14PTGS2, CDKN1A, CXCL8, BCL2, NGF, CCND1, BAX, SPP1, CASP3, TP53, SKP2, NTRK1, CDKN1B, ANGPT12NTRK1, NGF
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NGFYES3JUN, FOS, ING40
DSTYES2IRF2, IRF10
DNMT1YES6SP1, APC, STAT3, NPM1, TP53, EP3000
NTRK1YES2MYCN, ING40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NGFKIF1ANo1NTRK1
NGFDNMT1No1NTRK1
NGFATL3No1NTRK1
NGFNTRK1Yes3NTRK1, SORT1, NGFR
NGFATL1No1NTRK1
NGFIKBKAPNo1NTRK1
NGFSPTLC2No1NTRK1
WNK1DSTNo2MED4, MMS19
WNK1DNMT1No1YWHAQ
WNK1NTRK1No19PICALM, UPF2, VCP, HNRNPD, YWHAE, GAK, CSDE1, CLTC, PPP1CA, NEDD4L, COPS5, XPO1, PFKP, MMS19, YWHAG, YWHAB, YWHAQ, RANBP9, YWHAZ
WNK1IKBKAPNo2TSC22D1, MMS19
WNK1SPTLC1No1ADRB2
KIF1ADSTNo1SIRT7
KIF1ADNMT1No5SP1, NTRK1, DLG4, SIRT7, TRIM27
KIF1AATL3No1NTRK1
KIF1ANTRK1Yes9PSMC3, MED1, RNF31, KIF5B, EGFR, NTRK1, MAPK8IP3, PSMA3, FXR2
KIF1AATL1No1NTRK1
KIF1AIKBKAPNo3NTRK1, EGFR, SIRT7
KIF1ASPTLC1No2RGS20, EGFR
KIF1ASPTLC2No1NTRK1
DSTDNMT1No2SIRT7, CDK2
DSTNTRK1No17IQGAP1, EXOC1, CDK2, CDC5L, DCTN1, ADD1, PRMT5, PAK2, PPP1CB, PRKD2, MYH9, DBN1, MAPRE1, KIAA0368, LIMA1, MCM2, MMS19
DSTIKBKAPNo4CCDC8, SIRT7, CDC5L, MMS19
DNMT1ATL3No1NTRK1
DNMT1NTRK1Yes25MTA2, HELLS, HSPA4, HSPA5, CTBP1, KDM1A, DNAJC2, MTA1, DNMT1, CSNK2B, CHD4, STAT3, TRIM28, SMARCA5, GCN1L1, PCNA, PARP1, USP7, UHRF1, CDK2, YWHAQ, HDAC2, RB1, NTRK1, RBBP4
DNMT1ATL1No1NTRK1
DNMT1IKBKAPNo2NTRK1, SIRT7
DNMT1SPTLC2No1NTRK1
ATL3NTRK1Yes30CANX, ARCN1, VAPB, TROVE2, POR, PHB, GART, ITGB1, SRSF6, ETFB, EIF3B, ATL2, TPR, DVL3, LONP1, RTN4, SRPRB, EEF1G, RAB5C, ESYT1, FASTKD5, ATP2B1, HADHA, USP15, ATP5A1, EEF1B2, ZNF609, NTRK1, ALDH1B1, PHB2
ATL3ATL1No1NTRK1
ATL3IKBKAPNo1NTRK1
ATL3SPTLC2No1NTRK1
ATL3FAM134BNo1APP
NTRK1ATL1Yes1NTRK1
NTRK1IKBKAPYes29DNAJB11, CDC5L, NUP50, PRDX1, PSMC4, PPP6R1, EGFR, FOCAD, CHUK, CCT5, PSMD11, SHC1, IKBKAP, PSMD4, OTUB1, DYNC1H1, PRKDC, BAG6, PSMA2, MMS19, ACACA, FLNA, PSMC5, USP9X, PKM, ELP3, ELP2, NTRK1, CUL3
NTRK1SPTLC1No5NCSTN, MAGED1, EGFR, AUP1, MED12
NTRK1SPTLC2Yes2NTRK1, NOTCH3
ATL1IKBKAPNo1NTRK1
ATL1SPTLC2No1NTRK1
IKBKAPSPTLC1No2MYC, EGFR
IKBKAPSPTLC2No1NTRK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
WNK1NTRK1No1MYC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
WNK1KIF1ANo-1UBC
WNK1DNMT1No-2UBC, AKT1
WNK1ATL3No-1UBC
WNK1SPTLC2No-1UBC
KIF1ADNMT1No-1UBC
KIF1AATL3No-1UBC
KIF1ASPTLC2No-1UBC
DNMT1ATL3No-1UBC
DNMT1SPTLC2No-1UBC
ATL3SPTLC2No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
NGFNTRK1YesNGF-TrkA complex0
SPTLC1SPTLC2YesSerine-palmitoyltransferase (SPT) complex1SPTLC3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
NGFNTRK1Yes2NTRK1, NGF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493SPTLC2, DNMT1, SPTLC1
Apoptosishsa042106.232NTRK1, NGF
Neurotrophin signaling pathwayhsa047225.782NTRK1, NGF
Inflammatory mediator regulation of TRP channelshsa047506.072NTRK1, NGF
Sphingolipid metabolismhsa006007.152SPTLC2, SPTLC1
MAPK signaling pathwayhsa040104.632NTRK1, NGF

NET-GE enrichment

Term New enriched termICP valueGenes
Sphingolipid metabolism (hsa00600) -7.150.015SPTLC2, SPTLC1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Prolonged ERK activation eventsR-HSA-1698935.112NTRK1, NGF
Signalling to STAT3R-HSA-19874511.42NTRK1, NGF
PI3K/AKT activationR-HSA-1982036.322NTRK1, NGF
Signalling by NGFR-HSA-1665204.232NTRK1, NGF
Sphingolipid de novo biosynthesisR-HSA-16606617.982SPTLC2, SPTLC1
Signalling to p38 via RIT and RINR-HSA-1877065.122NTRK1, NGF
Frs2-mediated activationR-HSA-1709685.122NTRK1, NGF
TRKA activation by NGFR-HSA-18704211.982NTRK1, NGF
ARMS-mediated activationR-HSA-1709845.122NTRK1, NGF
Sphingolipid metabolismR-HSA-4281576.792SPTLC2, SPTLC1
Signalling to RASR-HSA-1670445.082NTRK1, NGF
MetabolismR-HSA-14307282.342SPTLC2, SPTLC1
Signal TransductionR-HSA-1625821.782NTRK1, NGF
Signalling to ERKsR-HSA-1876875.042NTRK1, NGF
Metabolism of lipids and lipoproteinsR-HSA-5568333.792SPTLC2, SPTLC1
Retrograde neurotrophin signallingR-HSA-1775049.282NTRK1, NGF
Activation of TRKA receptorsR-HSA-18701510.42NTRK1, NGF
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512NTRK1, NGF
PLC-gamma1 signallingR-HSA-1670217.892NTRK1, NGF

NET-GE enrichment

Term New enriched termICP valueGenes
Signalling to STAT3 (R-HSA-198745) -11.40.0NTRK1, NGF
PLC-gamma1 signalling (R-HSA-167021) -7.890.035NTRK1, NGF
Activation of TRKA receptors (R-HSA-187015) -10.40.005NTRK1, NGF
Sphingolipid de novo biosynthesis (R-HSA-1660661) -7.980.031SPTLC2, SPTLC1
TRKA activation by NGF (R-HSA-187042) -11.980.0NTRK1, NGF
Retrograde neurotrophin signalling (R-HSA-177504) -9.280.005NTRK1, NGF
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1813FAM134B, KIF1A, NGF, PRDM12, IKBKAP, SPTLC1, WNK1, DNMT1, ATL3, NTRK1, ATL1, SPTLC2, DST
catalytic activity (GO:0003824) 1.0511KIF1A, PRDM12, IKBKAP, SPTLC1, WNK1, DNMT1, ATL3, NTRK1, ATL1, SPTLC2, DST
protein binding (GO:0005515) 0.4611FAM134B, KIF1A, NGF, IKBKAP, SPTLC1, WNK1, DNMT1, ATL3, NTRK1, ATL1, DST
organic cyclic compound binding (GO:0097159) 1.057KIF1A, PRDM12, WNK1, DNMT1, NTRK1, ATL1, ATL3
transferase activity (GO:0016740) 1.957PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
heterocyclic compound binding (GO:1901363) 1.067KIF1A, PRDM12, WNK1, DNMT1, NTRK1, ATL1, ATL3
ion binding (GO:0043167) 1.367PRDM12, SPTLC2, WNK1, DNMT1, SPTLC1, ATL1, DST
small molecule binding (GO:0036094) 1.896KIF1A, WNK1, DNMT1, NTRK1, ATL1, ATL3
nucleoside phosphate binding (GO:1901265) 1.966KIF1A, WNK1, DNMT1, NTRK1, ATL1, ATL3
nucleotide binding (GO:0000166) 1.966KIF1A, WNK1, DNMT1, NTRK1, ATL1, ATL3
cation binding (GO:0043169) 1.45ATL1, WNK1, DNMT1, DST, PRDM12
carbohydrate derivative binding (GO:0097367) 2.035NTRK1, WNK1, KIF1A, ATL1, ATL3
purine ribonucleoside triphosphate binding (GO:0035639) 2.225NTRK1, WNK1, KIF1A, ATL1, ATL3
purine nucleoside binding (GO:0001883) 2.225NTRK1, WNK1, KIF1A, ATL1, ATL3
ribonucleoside binding (GO:0032549) 2.225NTRK1, WNK1, KIF1A, ATL1, ATL3
purine ribonucleotide binding (GO:0032555) 2.25NTRK1, WNK1, KIF1A, ATL1, ATL3
purine nucleotide binding (GO:0017076) 2.195NTRK1, WNK1, KIF1A, ATL1, ATL3
metal ion binding (GO:0046872) 1.415ATL1, WNK1, DNMT1, DST, PRDM12
purine ribonucleoside binding (GO:0032550) 2.225NTRK1, WNK1, KIF1A, ATL1, ATL3
ribonucleotide binding (GO:0032553) 2.195NTRK1, WNK1, KIF1A, ATL1, ATL3
nucleoside binding (GO:0001882) 2.215NTRK1, WNK1, KIF1A, ATL1, ATL3
hydrolase activity (GO:0016787) 1.94ATL1, KIF1A, ATL3, DST
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.034ATL1, KIF1A, ATL3, DST
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.034ATL1, KIF1A, ATL3, DST
enzyme binding (GO:0019899) 2.274NTRK1, WNK1, DNMT1, IKBKAP
nucleoside-triphosphatase activity (GO:0017111) 3.094ATL1, KIF1A, ATL3, DST
pyrophosphatase activity (GO:0016462) 3.044ATL1, KIF1A, ATL3, DST
receptor binding (GO:0005102) 2.434NTRK1, DNMT1, NGF, DST
identical protein binding (GO:0042802) 2.634NTRK1, ATL1, ATL3, DST
adenyl nucleotide binding (GO:0030554) 2.43NTRK1, WNK1, KIF1A
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773NTRK1, WNK1, IKBKAP
enzyme regulator activity (GO:0030234) 2.853WNK1, IKBKAP, NGF
kinase activity (GO:0016301) 2.933NTRK1, WNK1, IKBKAP
macromolecular complex binding (GO:0044877) 2.613IKBKAP, DNMT1, DST
nucleic acid binding (GO:0003676) 1.443ATL1, DNMT1, PRDM12
adenyl ribonucleotide binding (GO:0032559) 2.413NTRK1, WNK1, KIF1A
molecular function regulator (GO:0098772) 2.513WNK1, IKBKAP, NGF
ATP binding (GO:0005524) 2.433NTRK1, WNK1, KIF1A
cytokine receptor binding (GO:0005126) 4.142NTRK1, NGF
kinase regulator activity (GO:0019207) 4.52WNK1, IKBKAP
neurotrophin receptor binding (GO:0005165) 7.172NTRK1, NGF
pyridoxal phosphate binding (GO:0030170) 5.832SPTLC2, SPTLC1
ATPase activity (GO:0016887) 3.652KIF1A, DST
DNA binding (GO:0003677) 1.922DNMT1, PRDM12
methyltransferase activity (GO:0008168) 4.352DNMT1, PRDM12
enzyme inhibitor activity (GO:0004857) 3.782WNK1, NGF
anion binding (GO:0043168) 4.172SPTLC2, SPTLC1
guanyl ribonucleotide binding (GO:0032561) 3.732ATL1, ATL3
serine C-palmitoyltransferase activity (GO:0004758) 8.132SPTLC2, SPTLC1
transferase activity, transferring one-carbon groups (GO:0016741) 4.32DNMT1, PRDM12
transferase activity, transferring acyl groups (GO:0016746) 4.22SPTLC2, SPTLC1
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747) 4.372SPTLC2, SPTLC1
protein kinase activity (GO:0004672) 3.272NTRK1, WNK1
protein complex binding (GO:0032403) 3.092IKBKAP, DST
C-palmitoyltransferase activity (GO:0016454) 8.132SPTLC2, SPTLC1
protein homodimerization activity (GO:0042803) 3.162NTRK1, DST
tubulin binding (GO:0015631) 4.12KIF1A, DST
protein kinase regulator activity (GO:0019887) 4.62WNK1, IKBKAP
microtubule binding (GO:0008017) 4.422KIF1A, DST
GTPase activity (GO:0003924) 4.312ATL1, ATL3
kinase binding (GO:0019900) 3.322NTRK1, WNK1
cofactor binding (GO:0048037) 4.162SPTLC2, SPTLC1
signal transducer activity (GO:0004871) 2.282NTRK1, IKBKAP
cytoskeletal protein binding (GO:0008092) 3.022KIF1A, DST
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082NTRK1, WNK1
guanyl nucleotide binding (GO:0019001) 3.732ATL1, ATL3
protein dimerization activity (GO:0046983) 2.722NTRK1, DST
GTP binding (GO:0005525) 3.782ATL1, ATL3
palmitoyltransferase activity (GO:0016409) 6.152SPTLC2, SPTLC1
C-acyltransferase activity (GO:0016408) 7.12SPTLC2, SPTLC1

NET-GE enrichment

Term New enriched termICP valueGenes
C-acyltransferase activity (GO:0016408) -7.10.005SPTLC2, SPTLC1
serine C-palmitoyltransferase activity (GO:0004758) -8.130.0SPTLC2, SPTLC1
neurotrophin receptor activity (GO:0005030) NEW8.350.001NTRK1, NGF
voltage-gated sodium channel activity (GO:0005248) NEW6.740.041NGF, SCN11A
nerve growth factor binding (GO:0048406) NEW7.950.003NTRK1, NGF
neurotrophin receptor binding (GO:0005165) -7.170.005NTRK1, NGF
neurotrophin binding (GO:0043121) NEW7.440.009NTRK1, NGF
C-palmitoyltransferase activity (GO:0016454) -8.130.0SPTLC2, SPTLC1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2613FAM134B, KIF1A, NGF, PRDM12, SPTLC2, SPTLC1, WNK1, DNMT1, ATL3, NTRK1, ATL1, IKBKAP, DST
biological regulation (GO:0065007) 0.3911FAM134B, NGF, PRDM12, IKBKAP, WNK1, DNMT1, SPTLC1, SCN11A, NTRK1, SPTLC2, DST
single-organism cellular process (GO:0044763) 0.6511FAM134B, KIF1A, NGF, PRDM12, SPTLC2, WNK1, DNMT1, SPTLC1, NTRK1, ATL1, DST
regulation of biological process (GO:0050789) 0.4511FAM134B, NGF, PRDM12, SPTLC2, WNK1, DNMT1, SPTLC1, SCN11A, NTRK1, IKBKAP, DST
single-organism process (GO:0044699) 0.4811FAM134B, KIF1A, NGF, PRDM12, SPTLC2, WNK1, DNMT1, SPTLC1, NTRK1, ATL1, DST
regulation of cellular process (GO:0050794) 0.510FAM134B, NGF, PRDM12, SPTLC2, WNK1, DNMT1, SPTLC1, NTRK1, IKBKAP, DST
primary metabolic process (GO:0044238) 0.698NGF, PRDM12, SPTLC2, WNK1, DNMT1, NTRK1, IKBKAP, SPTLC1
regulation of primary metabolic process (GO:0080090) 1.088NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
regulation of metabolic process (GO:0019222) 1.028NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
regulation of cellular metabolic process (GO:0031323) 1.078NGF, PRDM12, SPTLC2, WNK1, DNMT1, NTRK1, IKBKAP, SPTLC1
cellular metabolic process (GO:0044237) 0.698NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
organic substance metabolic process (GO:0071704) 0.638NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
cellular component organization (GO:0016043) 1.248FAM134B, NGF, IKBKAP, DNMT1, ATL3, NTRK1, ATL1, DST
metabolic process (GO:0008152) 0.588NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1, SPTLC2, SPTLC1
positive regulation of biological process (GO:0048518) 1.28NGF, PRDM12, SPTLC2, WNK1, DNMT1, NTRK1, IKBKAP, SPTLC1
cellular component organization or biogenesis (GO:0071840) 1.228FAM134B, NGF, IKBKAP, DNMT1, ATL3, NTRK1, ATL1, DST
positive regulation of cellular process (GO:0048522) 1.37NGF, PRDM12, SPTLC2, DNMT1, NTRK1, IKBKAP, SPTLC1
regulation of cellular protein metabolic process (GO:0032268) 1.996NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1
positive regulation of metabolic process (GO:0009893) 1.746NGF, PRDM12, SPTLC2, DNMT1, NTRK1, SPTLC1
regulation of macromolecule metabolic process (GO:0060255) 1.086NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1
cellular developmental process (GO:0048869) 1.826NGF, PRDM12, WNK1, DNMT1, NTRK1, ATL1
positive regulation of cellular metabolic process (GO:0031325) 1.816NGF, PRDM12, SPTLC2, DNMT1, NTRK1, SPTLC1
regulation of protein metabolic process (GO:0051246) 1.936NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1
macromolecule metabolic process (GO:0043170) 0.836NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1
cellular nitrogen compound metabolic process (GO:0034641) 1.226NGF, PRDM12, SPTLC2, DNMT1, IKBKAP, SPTLC1
nitrogen compound metabolic process (GO:0006807) 1.136NGF, PRDM12, SPTLC2, DNMT1, IKBKAP, SPTLC1
signal transduction (GO:0007165) 1.286NGF, IKBKAP, WNK1, DNMT1, NTRK1, DST
regulation of protein modification process (GO:0031399) 2.326NGF, PRDM12, IKBKAP, WNK1, DNMT1, NTRK1
negative regulation of biological process (GO:0048519) 1.336FAM134B, NGF, WNK1, DNMT1, NTRK1, DST
negative regulation of cellular process (GO:0048523) 1.416FAM134B, NGF, WNK1, DNMT1, NTRK1, DST
developmental process (GO:0032502) 1.365NTRK1, WNK1, DNMT1, ATL1, NGF
organic substance biosynthetic process (GO:1901576) 1.345SPTLC2, DNMT1, IKBKAP, PRDM12, SPTLC1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595SPTLC2, DNMT1, IKBKAP, PRDM12, SPTLC1
cellular macromolecule metabolic process (GO:0044260) 0.935NTRK1, IKBKAP, DNMT1, WNK1, PRDM12
response to stimulus (GO:0050896) 1.225NTRK1, IKBKAP, DNMT1, DST, SCN11A
biosynthetic process (GO:0009058) 1.325IKBKAP, DNMT1, SPTLC2, PRDM12, SPTLC1
single-organism developmental process (GO:0044767) 1.495NTRK1, WNK1, DNMT1, ATL1, NGF
cellular biosynthetic process (GO:0044249) 1.375SPTLC2, IKBKAP, DNMT1, SPTLC1, PRDM12
phosphate-containing compound metabolic process (GO:0006796) 2.165NTRK1, SPTLC2, WNK1, IKBKAP, SPTLC1
phosphorus metabolic process (GO:0006793) 2.155NTRK1, SPTLC2, IKBKAP, WNK1, SPTLC1
regulation of gene expression (GO:0010468) 1.375NTRK1, IKBKAP, DNMT1, NGF, PRDM12
cellular component assembly (GO:0022607) 2.144ATL1, IKBKAP, ATL3, DST
regulation of phosphate metabolic process (GO:0019220) 2.354NTRK1, WNK1, IKBKAP, NGF
macromolecular complex subunit organization (GO:0043933) 2.144IKBKAP, DNMT1, ATL1, ATL3
regulation of cellular biosynthetic process (GO:0031326) 1.384NTRK1, IKBKAP, DNMT1, PRDM12
regulation of cellular component organization (GO:0051128) 2.014NTRK1, DNMT1, PRDM12, NGF
intracellular signal transduction (GO:0035556) 2.394NTRK1, WNK1, DNMT1, NGF
establishment of localization (GO:0051234) 1.484WNK1, KIF1A, ATL3, SCN11A
positive regulation of macromolecule metabolic process (GO:0010604) 1.814NTRK1, DNMT1, PRDM12, NGF
regulation of kinase activity (GO:0043549) 3.074NTRK1, WNK1, IKBKAP, NGF
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464NTRK1, IKBKAP, DNMT1, PRDM12
positive regulation of protein metabolic process (GO:0051247) 2.434NTRK1, DNMT1, PRDM12, NGF
positive regulation of cellular protein metabolic process (GO:0032270) 2.494NTRK1, DNMT1, PRDM12, NGF
transport (GO:0006810) 1.514WNK1, KIF1A, ATL3, SCN11A
regulation of molecular function (GO:0065009) 1.784NTRK1, WNK1, IKBKAP, NGF
positive regulation of cellular component organization (GO:0051130) 2.684NTRK1, DNMT1, PRDM12, NGF
organelle organization (GO:0006996) 2.024FAM134B, ATL1, ATL3, DST
regulation of protein kinase activity (GO:0045859) 3.154NTRK1, WNK1, IKBKAP, NGF
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434NTRK1, IKBKAP, DNMT1, PRDM12
regulation of catalytic activity (GO:0050790) 1.974NTRK1, WNK1, IKBKAP, NGF
regulation of biosynthetic process (GO:0009889) 1.374NTRK1, IKBKAP, DNMT1, PRDM12
regulation of nucleic acid-templated transcription (GO:1903506) 1.554NTRK1, IKBKAP, DNMT1, PRDM12
regulation of phosphorus metabolic process (GO:0051174) 2.354NTRK1, WNK1, IKBKAP, NGF
macromolecule modification (GO:0043412) 1.734NTRK1, WNK1, DNMT1, IKBKAP
microtubule-based process (GO:0007017) 3.544NTRK1, KIF1A, NGF, DST
regulation of nitrogen compound metabolic process (GO:0051171) 1.364NTRK1, IKBKAP, DNMT1, PRDM12
regulation of multicellular organismal process (GO:0051239) 1.874NTRK1, WNK1, NGF, SCN11A
regulation of RNA biosynthetic process (GO:2001141) 1.554NTRK1, IKBKAP, DNMT1, PRDM12
movement of cell or subcellular component (GO:0006928) 2.614NTRK1, KIF1A, NGF, DST
localization (GO:0051179) 1.44WNK1, KIF1A, ATL3, SCN11A
regulation of phosphorylation (GO:0042325) 2.54NTRK1, WNK1, IKBKAP, NGF
regulation of protein phosphorylation (GO:0001932) 2.574NTRK1, WNK1, IKBKAP, NGF
organonitrogen compound metabolic process (GO:1901564) 2.324SPTLC2, DNMT1, SPTLC1, NGF
protein metabolic process (GO:0019538) 1.454NTRK1, WNK1, IKBKAP, NGF
positive regulation of protein modification process (GO:0031401) 2.74NTRK1, DNMT1, PRDM12, NGF
regulation of transferase activity (GO:0051338) 2.884NTRK1, WNK1, IKBKAP, NGF
regulation of transcription, DNA-templated (GO:0006355) 1.564NTRK1, IKBKAP, DNMT1, PRDM12
regulation of macromolecule biosynthetic process (GO:0010556) 1.434NTRK1, IKBKAP, DNMT1, PRDM12
regulation of RNA metabolic process (GO:0051252) 1.524NTRK1, IKBKAP, DNMT1, PRDM12
cell part morphogenesis (GO:0032990) 3.993NTRK1, ATL1, NGF
negative regulation of metabolic process (GO:0009892) 1.933WNK1, DNMT1, NGF
RNA biosynthetic process (GO:0032774) 1.843IKBKAP, DNMT1, PRDM12
cell projection organization (GO:0030030) 3.143NTRK1, ATL1, NGF
phosphorylation (GO:0016310) 2.633NTRK1, WNK1, IKBKAP
cell differentiation (GO:0030154) 2.143NTRK1, DNMT1, PRDM12
nucleic acid metabolic process (GO:0090304) 1.463IKBKAP, DNMT1, PRDM12
regulation of neuron apoptotic process (GO:0043523) 4.473FAM134B, NTRK1, NGF
negative regulation of neuron apoptotic process (GO:0043524) 4.823FAM134B, NTRK1, NGF
small molecule metabolic process (GO:0044281) 2.383SPTLC2, DNMT1, SPTLC1
cell surface receptor signaling pathway (GO:0007166) 2.093NTRK1, DST, NGF
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583NTRK1, WNK1, NGF
organic cyclic compound biosynthetic process (GO:1901362) 1.663IKBKAP, DNMT1, PRDM12
organic cyclic compound metabolic process (GO:1901360) 1.263IKBKAP, DNMT1, PRDM12
cellular protein metabolic process (GO:0044267) 1.633NTRK1, WNK1, IKBKAP
single-organism metabolic process (GO:0044710) 1.633SPTLC2, DNMT1, SPTLC1
regulation of localization (GO:0032879) 1.943WNK1, IKBKAP, SCN11A
negative regulation of macromolecule metabolic process (GO:0010605) 2.013WNK1, DNMT1, NGF
protein complex subunit organization (GO:0071822) 2.63IKBKAP, ATL1, ATL3
anatomical structure morphogenesis (GO:0009653) 2.533NTRK1, ATL1, NGF
regulation of apoptotic process (GO:0042981) 2.53NTRK1, FAM134B, NGF
microtubule-based movement (GO:0007018) 4.393NTRK1, KIF1A, NGF
cellular component morphogenesis (GO:0032989) 3.53NTRK1, ATL1, NGF
macromolecular complex assembly (GO:0065003) 2.553IKBKAP, ATL1, ATL3
regulation of programmed cell death (GO:0043067) 2.493FAM134B, NTRK1, NGF
negative regulation of apoptotic process (GO:0043066) 3.043NTRK1, FAM134B, NGF
nucleic acid-templated transcription (GO:0097659) 1.913IKBKAP, DNMT1, PRDM12
positive regulation of molecular function (GO:0044093) 2.233NTRK1, WNK1, NGF
regulation of biological quality (GO:0065008) 1.683WNK1, NGF, SCN11A
negative regulation of programmed cell death (GO:0043069) 3.023NTRK1, FAM134B, NGF
heterocycle biosynthetic process (GO:0018130) 1.73IKBKAP, DNMT1, PRDM12
regulation of hydrolase activity (GO:0051336) 2.533NTRK1, WNK1, NGF
protein phosphorylation (GO:0006468) 2.893NTRK1, WNK1, IKBKAP
negative regulation of cellular metabolic process (GO:0031324) 2.013WNK1, DNMT1, NGF
nucleobase-containing compound metabolic process (GO:0006139) 1.353IKBKAP, DNMT1, PRDM12
negative regulation of cell death (GO:0060548) 2.953NTRK1, FAM134B, NGF
protein complex assembly (GO:0006461) 2.783IKBKAP, ATL1, ATL3
cellular aromatic compound metabolic process (GO:0006725) 1.33IKBKAP, DNMT1, PRDM12
negative regulation of protein metabolic process (GO:0051248) 2.823WNK1, DNMT1, NGF
cellular protein modification process (GO:0006464) 1.793NTRK1, WNK1, IKBKAP
cellular macromolecule biosynthetic process (GO:0034645) 1.663IKBKAP, DNMT1, PRDM12
response to stress (GO:0006950) 1.83NTRK1, DNMT1, DST
macromolecule biosynthetic process (GO:0009059) 1.613IKBKAP, DNMT1, PRDM12
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723IKBKAP, DNMT1, PRDM12
response to chemical (GO:0042221) 1.983NTRK1, DNMT1, SCN11A
regulation of neuron death (GO:1901214) 4.193NTRK1, FAM134B, NGF
negative regulation of neuron death (GO:1901215) 4.573NTRK1, FAM134B, NGF
heterocycle metabolic process (GO:0046483) 1.313IKBKAP, DNMT1, PRDM12
RNA metabolic process (GO:0016070) 1.593IKBKAP, DNMT1, PRDM12
negative regulation of cellular protein metabolic process (GO:0032269) 2.883WNK1, DNMT1, NGF
protein modification process (GO:0036211) 1.793NTRK1, WNK1, IKBKAP
cell projection morphogenesis (GO:0048858) 4.053NTRK1, ATL1, NGF
cellular amide metabolic process (GO:0043603) 3.233SPTLC2, SPTLC1, NGF
anatomical structure development (GO:0048856) 1.583NTRK1, WNK1, DNMT1
response to drug (GO:0042493) 3.713NTRK1, DNMT1, SCN11A
neuron projection morphogenesis (GO:0048812) 4.343NTRK1, ATL1, NGF
transcription, DNA-templated (GO:0006351) 1.913IKBKAP, DNMT1, PRDM12
aromatic compound biosynthetic process (GO:0019438) 1.73IKBKAP, DNMT1, PRDM12
regulation of cell death (GO:0010941) 2.433FAM134B, NTRK1, NGF
positive regulation of histone methylation (GO:0031062) 6.22DNMT1, PRDM12
regulation of transport (GO:0051049) 2.242WNK1, SCN11A
positive regulation of response to stimulus (GO:0048584) 2.182NTRK1, NGF
regulation of response to stimulus (GO:0048583) 1.542NTRK1, NGF
activation of protein kinase activity (GO:0032147) 4.082NTRK1, NGF
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242NTRK1, NGF
neuron differentiation (GO:0030182) 4.172NTRK1, DNMT1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542NTRK1, NGF
regulation of cell projection organization (GO:0031344) 3.382NTRK1, NGF
regulation of transmembrane transport (GO:0034762) 3.742WNK1, SCN11A
positive regulation of cell projection organization (GO:0031346) 3.992NTRK1, NGF
cellular response to stimulus (GO:0051716) 1.972NTRK1, DNMT1
single-organism biosynthetic process (GO:0044711) 2.82SPTLC2, SPTLC1
regulation of signal transduction (GO:0009966) 1.842NTRK1, NGF
positive regulation of signal transduction (GO:0009967) 2.52NTRK1, NGF
response to growth factor (GO:0070848) 4.142NTRK1, DNMT1
peptidyl-amino acid modification (GO:0018193) 2.982NTRK1, WNK1
regulation of neuron differentiation (GO:0045664) 3.392NTRK1, NGF
positive regulation of neuron differentiation (GO:0045666) 3.982NTRK1, NGF
positive regulation of lipid metabolic process (GO:0045834) 4.882SPTLC2, SPTLC1
positive regulation of cell development (GO:0010720) 3.572NTRK1, NGF
negative regulation of molecular function (GO:0044092) 2.742WNK1, NGF
sphingolipid metabolic process (GO:0006665) 4.792SPTLC2, SPTLC1
(GO:1905269) 5.252DNMT1, PRDM12
sphinganine metabolic process (GO:0006667) 8.632SPTLC2, SPTLC1
regulation of cell proliferation (GO:0042127) 2.412NTRK1, DNMT1
regulation of lipophagy (GO:1904502) 8.632SPTLC2, SPTLC1
neurotrophin signaling pathway (GO:0038179) 6.552NTRK1, NGF
cell development (GO:0048468) 3.282NTRK1, WNK1
response to activity (GO:0014823) 5.472NTRK1, DNMT1
sensory perception (GO:0007600) 2.932FAM134B, NTRK1
positive regulation of lipophagy (GO:1904504) 8.632SPTLC2, SPTLC1
regulation of histone methylation (GO:0031060) 5.652DNMT1, PRDM12
positive regulation of neuron projection development (GO:0010976) 4.262NTRK1, NGF
regulation of neuron projection development (GO:0010975) 3.692NTRK1, NGF
aging (GO:0007568) 4.162NTRK1, DNMT1
response to inorganic substance (GO:0010035) 3.562NTRK1, DNMT1
response to organic substance (GO:0010033) 2.22NTRK1, DNMT1
system process (GO:0003008) 2.32NTRK1, FAM134B
positive regulation of signaling (GO:0023056) 2.412NTRK1, NGF
positive regulation of phosphorylation (GO:0042327) 2.92NTRK1, NGF
response to external stimulus (GO:0009605) 2.552NTRK1, DNMT1
organonitrogen compound biosynthetic process (GO:1901566) 2.852SPTLC2, SPTLC1
response to organonitrogen compound (GO:0010243) 3.22NTRK1, DNMT1
positive regulation of organelle organization (GO:0010638) 3.382DNMT1, PRDM12
response to nutrient levels (GO:0031667) 3.772NTRK1, DNMT1
immune system process (GO:0002376) 2.292NTRK1, IKBKAP
organophosphate metabolic process (GO:0019637) 3.042SPTLC2, SPTLC1
ceramide metabolic process (GO:0006672) 5.412SPTLC2, SPTLC1
sphingosine metabolic process (GO:0006670) 7.432SPTLC2, SPTLC1
positive regulation of catabolic process (GO:0009896) 3.942SPTLC2, SPTLC1
regulation of catabolic process (GO:0009894) 3.522SPTLC2, SPTLC1
positive regulation of kinase activity (GO:0033674) 3.542NTRK1, NGF
small molecule biosynthetic process (GO:0044283) 3.792SPTLC2, SPTLC1
positive regulation of gene expression (GO:0010628) 2.352DNMT1, NGF
positive regulation of histone modification (GO:0031058) 5.322DNMT1, PRDM12
positive regulation of transferase activity (GO:0051347) 3.312NTRK1, NGF
negative regulation of hydrolase activity (GO:0051346) 3.742WNK1, NGF
positive regulation of hydrolase activity (GO:0051345) 2.912NTRK1, NGF
ammonium ion metabolic process (GO:0097164) 5.262SPTLC2, SPTLC1
negative regulation of catalytic activity (GO:0043086) 3.02WNK1, NGF
sphingomyelin biosynthetic process (GO:0006686) 8.122SPTLC2, SPTLC1
positive regulation of catalytic activity (GO:0043085) 2.42NTRK1, NGF
sphingomyelin metabolic process (GO:0006684) 7.162SPTLC2, SPTLC1
sphingoid biosynthetic process (GO:0046520) 7.532SPTLC2, SPTLC1
sensory perception of pain (GO:0019233) 5.622FAM134B, NTRK1
methylation (GO:0032259) 4.062DNMT1, PRDM12
sphingolipid biosynthetic process (GO:0030148) 5.382SPTLC2, SPTLC1
lipid metabolic process (GO:0006629) 2.682SPTLC2, SPTLC1
regulation of developmental process (GO:0050793) 2.12NTRK1, NGF
ion transport (GO:0006811) 2.662WNK1, SCN11A
positive regulation of MAPK cascade (GO:0043410) 3.572NTRK1, NGF
organic hydroxy compound biosynthetic process (GO:1901617) 4.982SPTLC2, SPTLC1
response to temperature stimulus (GO:0009266) 4.712NTRK1, DNMT1
neurotrophin TRK receptor signaling pathway (GO:0048011) 6.962NTRK1, NGF
positive regulation of intracellular signal transduction (GO:1902533) 2.952NTRK1, NGF
regulation of intracellular signal transduction (GO:1902531) 2.312NTRK1, NGF
organophosphate biosynthetic process (GO:0090407) 3.672SPTLC2, SPTLC1
inositol lipid-mediated signaling (GO:0048017) 4.912NTRK1, NGF
regulation of ion transmembrane transport (GO:0034765) 3.772WNK1, SCN11A
intracellular transport (GO:0046907) 2.672KIF1A, ATL3
phospholipid biosynthetic process (GO:0008654) 4.392SPTLC2, SPTLC1
negative regulation of protein modification process (GO:0031400) 3.42WNK1, DNMT1
cellular response to nitrogen compound (GO:1901699) 3.792NTRK1, DNMT1
positive regulation of nervous system development (GO:0051962) 3.642NTRK1, NGF
regulation of nervous system development (GO:0051960) 3.12NTRK1, NGF
positive regulation of chromosome organization (GO:2001252) 4.762DNMT1, PRDM12
positive regulation of phosphorus metabolic process (GO:0010562) 2.782NTRK1, NGF
organic hydroxy compound metabolic process (GO:1901615) 3.842SPTLC2, SPTLC1
regulation of chromosome organization (GO:0033044) 4.112DNMT1, PRDM12
regulation of organelle organization (GO:0033043) 2.722DNMT1, PRDM12
response to radiation (GO:0009314) 3.692NTRK1, DNMT1
polyol biosynthetic process (GO:0046173) 6.472SPTLC2, SPTLC1
response to extracellular stimulus (GO:0009991) 3.712NTRK1, DNMT1
response to wounding (GO:0009611) 4.392NTRK1, DST
diol metabolic process (GO:0034311) 7.332SPTLC2, SPTLC1
regulation of MAP kinase activity (GO:0043405) 3.952NTRK1, NGF
diol biosynthetic process (GO:0034312) 7.652SPTLC2, SPTLC1
cellular response to chemical stimulus (GO:0070887) 2.572NTRK1, DNMT1
regulation of signaling (GO:0023051) 1.722NTRK1, NGF
positive regulation of cell communication (GO:0010647) 2.412NTRK1, NGF
regulation of cell communication (GO:0010646) 1.732NTRK1, NGF
protein autophosphorylation (GO:0046777) 4.462NTRK1, WNK1
response to organic cyclic compound (GO:0014070) 3.072NTRK1, DNMT1
regulation of MAPK cascade (GO:0043408) 3.222NTRK1, NGF
response to endogenous stimulus (GO:0009719) 2.792NTRK1, DNMT1
regulation of neurogenesis (GO:0050767) 3.212NTRK1, NGF
regulation of system process (GO:0044057) 3.532WNK1, SCN11A
phosphatidylinositol-mediated signaling (GO:0048015) 4.932NTRK1, NGF
positive regulation of multicellular organismal process (GO:0051240) 2.492NTRK1, NGF
regulation of anatomical structure morphogenesis (GO:0022603) 2.792NTRK1, NGF
regulation of cell development (GO:0060284) 3.012NTRK1, NGF
positive regulation of neurogenesis (GO:0050769) 3.772NTRK1, NGF
membrane lipid biosynthetic process (GO:0046467) 4.992SPTLC2, SPTLC1
cellular localization (GO:0051641) 2.322KIF1A, ATL3
cellular response to endogenous stimulus (GO:0071495) 3.332NTRK1, DNMT1
phospholipid metabolic process (GO:0006644) 3.882SPTLC2, SPTLC1
multicellular organismal process (GO:0032501) 1.452FAM134B, NTRK1
membrane lipid metabolic process (GO:0006643) 4.512SPTLC2, SPTLC1
neurological system process (GO:0050877) 2.642FAM134B, NTRK1
alcohol biosynthetic process (GO:0046165) 5.542SPTLC2, SPTLC1
positive regulation of autophagy (GO:0010508) 5.412SPTLC2, SPTLC1
positive regulation of cell differentiation (GO:0045597) 3.012NTRK1, NGF
regulation of cell differentiation (GO:0045595) 2.422NTRK1, NGF
response to acid chemical (GO:0001101) 4.052NTRK1, DNMT1
axonogenesis (GO:0007409) 4.742NTRK1, ATL1
response to alkaloid (GO:0043279) 4.832NTRK1, DNMT1
cellular lipid metabolic process (GO:0044255) 2.922SPTLC2, SPTLC1
protein oligomerization (GO:0051259) 3.712ATL1, ATL3
amide biosynthetic process (GO:0043604) 3.62SPTLC2, SPTLC1
cellular response to growth factor stimulus (GO:0071363) 4.272NTRK1, DNMT1
positive regulation of developmental process (GO:0051094) 2.772NTRK1, NGF
positive regulation of protein kinase activity (GO:0045860) 3.612NTRK1, NGF
response to nitrogen compound (GO:1901698) 3.122NTRK1, DNMT1
regulation of chromatin organization (GO:1902275) 4.692DNMT1, PRDM12
activation of MAPKK activity (GO:0000186) 5.742NTRK1, NGF
cellular response to nerve growth factor stimulus (GO:1990090) 6.232NTRK1, DNMT1
positive regulation of macroautophagy (GO:0016239) 6.072SPTLC2, SPTLC1
regulation of cellular catabolic process (GO:0031329) 3.832SPTLC2, SPTLC1
polyol metabolic process (GO:0019751) 5.172SPTLC2, SPTLC1
positive regulation of cell death (GO:0010942) 3.322NTRK1, NGF
regulation of histone modification (GO:0031056) 4.852DNMT1, PRDM12
regulation of ion transport (GO:0043269) 3.42WNK1, SCN11A
endoplasmic reticulum organization (GO:0007029) 6.262ATL1, ATL3
cellular response to organonitrogen compound (GO:0071417) 3.872NTRK1, DNMT1
positive regulation of protein phosphorylation (GO:0001934) 2.952NTRK1, NGF
protein homooligomerization (GO:0051260) 4.212ATL1, ATL3
cellular response to organic substance (GO:0071310) 2.782NTRK1, DNMT1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242IKBKAP, DNMT1
positive regulation of cellular catabolic process (GO:0031331) 4.152SPTLC2, SPTLC1
regulation of autophagy (GO:0010506) 4.212SPTLC2, SPTLC1
positive regulation of programmed cell death (GO:0043068) 3.382NTRK1, NGF
regulation of macroautophagy (GO:0016241) 4.982SPTLC2, SPTLC1
positive regulation of phosphate metabolic process (GO:0045937) 2.782NTRK1, NGF
regulation of lipid metabolic process (GO:0019216) 4.082SPTLC2, SPTLC1
response to nerve growth factor (GO:1990089) 6.152NTRK1, DNMT1
response to ethanol (GO:0045471) 4.832NTRK1, DNMT1
establishment of localization in cell (GO:0051649) 2.472KIF1A, ATL3
regulation of histone H3-K9 methylation (GO:0051570) 6.782DNMT1, PRDM12
lipid biosynthetic process (GO:0008610) 3.492SPTLC2, SPTLC1
response to oxygen-containing compound (GO:1901700) 2.572NTRK1, DNMT1
response to abiotic stimulus (GO:0009628) 2.82NTRK1, DNMT1
response to alcohol (GO:0097305) 4.582NTRK1, DNMT1
regulation of lipid catabolic process (GO:0050994) 5.82SPTLC2, SPTLC1
positive regulation of lipid catabolic process (GO:0050996) 6.512SPTLC2, SPTLC1
alcohol metabolic process (GO:0006066) 4.22SPTLC2, SPTLC1
single-organism organelle organization (GO:1902589) 2.682FAM134B, DST
regulation of multicellular organismal development (GO:2000026) 2.312NTRK1, NGF
sphingoid metabolic process (GO:0046519) 7.162SPTLC2, SPTLC1
sphingosine biosynthetic process (GO:0046512) 7.652SPTLC2, SPTLC1
ceramide biosynthetic process (GO:0046513) 5.942SPTLC2, SPTLC1
sphinganine biosynthetic process (GO:0046511) 9.042SPTLC2, SPTLC1

NET-GE enrichment

Term New enriched termICP valueGenes
sphingosine metabolic process (GO:0006670) -7.430.016SPTLC2, SPTLC1
negative regulation of peptidyl-tyrosine phosphorylation (GO:0050732) NEW6.070.039NTRK1, DNMT1, NGF
cell part morphogenesis (GO:0032990) -3.990.019NTRK1, ATL1, NGF, DST
detection of mechanical stimulus involved in sensory perception of pain (GO:0050966) NEW7.650.04NTRK1, NGF
neuron projection morphogenesis (GO:0048812) -4.340.005NTRK1, ATL1, NGF, DST
cell projection morphogenesis (GO:0048858) -4.050.014NTRK1, ATL1, NGF, DST
sphingomyelin metabolic process (GO:0006684) -7.160.032SPTLC2, SPTLC1
diol metabolic process (GO:0034311) -7.330.019SPTLC2, SPTLC1
diol biosynthetic process (GO:0034312) -7.650.005SPTLC2, SPTLC1
sphingomyelin biosynthetic process (GO:0006686) -8.120.003SPTLC2, SPTLC1
axonogenesis (GO:0007409) -4.740.044NTRK1, ATL1, DST
sphingoid metabolic process (GO:0046519) -7.160.027SPTLC2, SPTLC1
sphinganine metabolic process (GO:0006667) -8.630.003SPTLC2, SPTLC1
sphingosine biosynthetic process (GO:0046512) -7.650.005SPTLC2, SPTLC1
sphingoid biosynthetic process (GO:0046520) -7.530.032SPTLC2, SPTLC1
sphinganine biosynthetic process (GO:0046511) -9.040.0SPTLC2, SPTLC1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1114FAM134B, KIF1A, NGF, PRDM12, IKBKAP, SPTLC1, WNK1, DNMT1, ATL3, SCN11A, NTRK1, ATL1, SPTLC2, DST
intracellular part (GO:0044424) 0.2813FAM134B, KIF1A, NGF, PRDM12, IKBKAP, SPTLC1, WNK1, DNMT1, ATL3, NTRK1, ATL1, SPTLC2, DST
organelle (GO:0043226) 0.413FAM134B, KIF1A, NGF, PRDM12, IKBKAP, SPTLC1, DNMT1, ATL3, SCN11A, NTRK1, ATL1, SPTLC2, DST
intracellular organelle (GO:0043229) 0.5112FAM134B, KIF1A, NGF, PRDM12, IKBKAP, SPTLC1, DNMT1, DST, NTRK1, ATL1, SPTLC2, ATL3
membrane-bounded organelle (GO:0043227) 0.4712FAM134B, NGF, PRDM12, IKBKAP, SPTLC1, DNMT1, DST, SCN11A, NTRK1, ATL1, SPTLC2, ATL3
intracellular organelle part (GO:0044446) 0.8111FAM134B, KIF1A, NGF, SPTLC2, SPTLC1, DNMT1, ATL3, NTRK1, ATL1, IKBKAP, DST
intracellular membrane-bounded organelle (GO:0043231) 0.611FAM134B, NGF, PRDM12, IKBKAP, SPTLC1, DNMT1, DST, NTRK1, ATL1, SPTLC2, ATL3
organelle part (GO:0044422) 0.7911FAM134B, KIF1A, NGF, IKBKAP, SPTLC1, DNMT1, ATL3, NTRK1, ATL1, SPTLC2, DST
cytoplasmic part (GO:0044444) 0.8210FAM134B, KIF1A, NGF, SPTLC2, SPTLC1, WNK1, ATL3, NTRK1, ATL1, DST
membrane part (GO:0044425) 0.959FAM134B, SPTLC2, SPTLC1, DST, SCN11A, NTRK1, ATL1, IKBKAP, ATL3
integral component of membrane (GO:0016021) 1.149FAM134B, SPTLC2, SPTLC1, DST, SCN11A, NTRK1, ATL1, IKBKAP, ATL3
membrane (GO:0016020) 0.689FAM134B, SPTLC2, SPTLC1, DST, SCN11A, NTRK1, ATL1, IKBKAP, ATL3
intrinsic component of membrane (GO:0031224) 1.139FAM134B, IKBKAP, SPTLC1, DST, SCN11A, NTRK1, ATL1, SPTLC2, ATL3
protein complex (GO:0043234) 1.517KIF1A, IKBKAP, DNMT1, SCN11A, NTRK1, SPTLC2, SPTLC1
cytoplasm (GO:0005737) 1.017KIF1A, IKBKAP, WNK1, DNMT1, NTRK1, ATL1, DST
macromolecular complex (GO:0032991) 1.357KIF1A, IKBKAP, DNMT1, SCN11A, NTRK1, SPTLC2, SPTLC1
endoplasmic reticulum part (GO:0044432) 2.736FAM134B, SPTLC2, SPTLC1, DST, ATL1, ATL3
endoplasmic reticulum (GO:0005783) 2.566FAM134B, SPTLC2, SPTLC1, DST, ATL1, ATL3
neuron part (GO:0097458) 2.646KIF1A, DNMT1, SCN11A, NTRK1, ATL1, DST
endoplasmic reticulum membrane (GO:0005789) 2.956FAM134B, SPTLC2, SPTLC1, DST, ATL1, ATL3
nucleus (GO:0005634) 1.074IKBKAP, DNMT1, DST, PRDM12
cell projection (GO:0042995) 2.474NTRK1, ATL1, DST, SCN11A
vesicle (GO:0031982) 1.644NTRK1, NGF, SCN11A, DST
neuron projection (GO:0043005) 3.124NTRK1, ATL1, DST, SCN11A
axon (GO:0030424) 4.154NTRK1, ATL1, DST, SCN11A
catalytic complex (GO:1902494) 2.93IKBKAP, SPTLC2, SPTLC1
intracellular non-membrane-bounded organelle (GO:0043232) 1.763IKBKAP, KIF1A, DST
cytoplasmic vesicle (GO:0031410) 2.873NTRK1, NGF, DST
membrane-bounded vesicle (GO:0031988) 1.713NGF, SCN11A, DST
membrane protein complex (GO:0098796) 2.843SPTLC2, SPTLC1, SCN11A
non-membrane-bounded organelle (GO:0043228) 1.763IKBKAP, KIF1A, DST
nuclear part (GO:0044428) 1.553IKBKAP, DNMT1, DST
intracellular vesicle (GO:0097708) 2.863NTRK1, NGF, DST
transferase complex (GO:1990234) 3.323IKBKAP, SPTLC2, SPTLC1
plasma membrane (GO:0005886) 1.393NTRK1, DST, SCN11A
plasma membrane part (GO:0044459) 1.953NTRK1, DST, SCN11A
supramolecular fiber (GO:0099512) 3.312KIF1A, DST
polymeric cytoskeletal fiber (GO:0099513) 3.312KIF1A, DST
microtubule (GO:0005874) 3.812KIF1A, DST
cytoskeleton (GO:0005856) 2.552KIF1A, DST
organelle membrane (GO:0031090) 1.972NTRK1, ATL1
vacuole (GO:0005773) 2.922NTRK1, NGF
Golgi apparatus part (GO:0044431) 3.02ATL1, NGF
cytoskeletal part (GO:0044430) 2.492KIF1A, DST
neuronal cell body (GO:0043025) 3.92NTRK1, DNMT1
Golgi apparatus (GO:0005794) 2.72FAM134B, ATL1
serine C-palmitoyltransferase complex (GO:0017059) 8.012SPTLC2, SPTLC1
bounding membrane of organelle (GO:0098588) 2.392NTRK1, ATL1
cytoplasmic region (GO:0099568) 4.512KIF1A, DST
cell body (GO:0044297) 3.742NTRK1, DNMT1
endoplasmic reticulum palmitoyltransferase complex (GO:0031211) 8.012SPTLC2, SPTLC1
palmitoyltransferase complex (GO:0002178) 7.722SPTLC2, SPTLC1
extracellular vesicle (GO:1903561) 1.892DST, SCN11A
extracellular exosome (GO:0070062) 1.892DST, SCN11A
extracellular organelle (GO:0043230) 1.892DST, SCN11A
cytosol (GO:0005829) 1.682WNK1, DST
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122DST, NGF
endosome (GO:0005768) 3.252NTRK1, NGF
extracellular region part (GO:0044421) 1.572DST, SCN11A

NET-GE enrichment

Term New enriched termICP valueGenes
lamellar body (GO:0042599) NEW6.860.039NTRK1, SPTLC1
serine C-palmitoyltransferase complex (GO:0017059) -8.010.002SPTLC2, SPTLC1
axon (GO:0030424) -4.150.001NTRK1, ATL1, SCN11A, DST, NGF
sodium channel complex (GO:0034706) NEW6.970.019NGF, SCN11A
neuron part (GO:0097458) -2.640.046KIF1A, NGF, IKBKAP, WNK1, DNMT1, SPTLC1, SCN11A, NTRK1, ATL1, DST
endoplasmic reticulum palmitoyltransferase complex (GO:0031211) -8.010.002SPTLC2, SPTLC1
neuron projection (GO:0043005) -3.120.005NTRK1, ATL1, KIF1A, DST, SCN11A
palmitoyltransferase complex (GO:0002178) -7.720.004SPTLC2, SPTLC1
endoplasmic reticulum membrane (GO:0005789) -2.950.036NGF, SPTLC2, SPTLC1, DNMT1, ATL3, ATL1, DST