Disease table of CREUTZFELDT-JAKOB DISEASE OMIM ID: 123400

Gene-disease associations table

GeneAssociated with CREUTZFELDT-JAKOB DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PRNPClinVar, OMIM, HUMSAVARHGNC link20p136603218, 245300, 123400, 137440, 600072, 606688
HLA-DQB1OMIMHGNC link6p21.323123400, PS212750, PS126200

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PRNPYES3SP1, XBP1, MTF10
HLA-DQB1YES6RFXANK, RFX5, RFXAP, CREB1, CIITA, DEK0
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cation binding (GO:0043169) 1.42PRNP, HLA-DQB1
metal ion binding (GO:0046872) 1.412PRNP, HLA-DQB1
binding (GO:0005488) 0.182PRNP, HLA-DQB1
ion binding (GO:0043167) 1.362HLA-DQB1, PRNP
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of lymphocyte activation (GO:0051249) 3.732PRNP, HLA-DQB1
regulation of cell-cell adhesion (GO:0022407) 3.792PRNP, HLA-DQB1
regulation of cell activation (GO:0050865) 3.532HLA-DQB1, PRNP
response to stimulus (GO:0050896) 1.222HLA-DQB1, PRNP
regulation of cell adhesion (GO:0030155) 3.272PRNP, HLA-DQB1
regulation of response to stimulus (GO:0048583) 1.542PRNP, HLA-DQB1
regulation of T cell activation (GO:0050863) 4.052HLA-DQB1, PRNP
regulation of cellular process (GO:0050794) 0.52PRNP, HLA-DQB1
regulation of leukocyte activation (GO:0002694) 3.62HLA-DQB1, PRNP
regulation of immune response (GO:0050776) 2.982PRNP, HLA-DQB1
biological regulation (GO:0065007) 0.392PRNP, HLA-DQB1
regulation of immune system process (GO:0002682) 2.52PRNP, HLA-DQB1
regulation of biological process (GO:0050789) 0.452HLA-DQB1, PRNP
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.012HLA-DQB1, PRNP

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of T cell activation (GO:0050863) -4.050.044PRNP, HLA-DQB1
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
Golgi apparatus (GO:0005794) 2.72PRNP, HLA-DQB1
integral component of membrane (GO:0016021) 1.142HLA-DQB1, PRNP
bounding membrane of organelle (GO:0098588) 2.392HLA-DQB1, PRNP
endoplasmic reticulum (GO:0005783) 2.562HLA-DQB1, PRNP
whole membrane (GO:0098805) 2.852HLA-DQB1, PRNP
membrane (GO:0016020) 0.682PRNP, HLA-DQB1
cell part (GO:0044464) 0.112PRNP, HLA-DQB1
cytoplasmic part (GO:0044444) 0.822HLA-DQB1, PRNP
intracellular membrane-bounded organelle (GO:0043231) 0.62HLA-DQB1, PRNP
intracellular organelle part (GO:0044446) 0.812PRNP, HLA-DQB1
intracellular organelle (GO:0043229) 0.512PRNP, HLA-DQB1
organelle part (GO:0044422) 0.792HLA-DQB1, PRNP
plasma membrane (GO:0005886) 1.392PRNP, HLA-DQB1
intracellular part (GO:0044424) 0.282HLA-DQB1, PRNP
membrane part (GO:0044425) 0.952HLA-DQB1, PRNP
membrane-bounded organelle (GO:0043227) 0.472PRNP, HLA-DQB1
organelle (GO:0043226) 0.42PRNP, HLA-DQB1
intrinsic component of membrane (GO:0031224) 1.132PRNP, HLA-DQB1
organelle membrane (GO:0031090) 1.972PRNP, HLA-DQB1