Disease table of CELIAC DISEASE OMIM ID: PS212750

Gene-disease associations table

GeneAssociated with CELIAC DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CTLA4ClinVar, OMIMHGNC link2q33.25616100, PS212750, 140300, 601388, 152700
HLA-DQB1OMIMHGNC link6p21.323123400, PS212750, PS126200
HLA-DQA1OMIMHGNC link6p21.321PS212750
MYO9BClinVar, OMIMHGNC link19p13.111PS212750

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
6p21.322HLA-DQB1, HLA-DQA1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
6p212HLA-DQB1, HLA-DQA1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22HLA-DQB1, HLA-DQA1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p2HLA-DQB1, HLA-DQA1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62HLA-DQB1, HLA-DQA1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
RFXANKNO15HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, HLA-DRB4, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQA1, HLA-DQB1
RFX5NO18HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, COL1A2, HDAC2, HLA-DRB4, IFNG, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQA1, HLA-DQB1
RFXAPNO15HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, HLA-DRB4, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQA1, HLA-DQB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CTLA4YES3FOXP3, MSC, LEF10
HLA-DQB1YES6RFXANK, RFX5, RFXAP, CREB1, CIITA, DEK0
HLA-DQA1YES4RFXANK, ILF3, RFXAP, RFX50
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
HLA-DQB1HLA-DQA1Yes3INS, HLA-DQA1, HLA-DQB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Rheumatoid arthritishsa053236.053CTLA4, HLA-DQA1, HLA-DQB1
Cell adhesion molecules (CAMs)hsa045145.363CTLA4, HLA-DQA1, HLA-DQB1
Autoimmune thyroid diseasehsa053206.623CTLA4, HLA-DQA1, HLA-DQB1
Inflammatory bowel disease (IBD)hsa053216.432HLA-DQA1, HLA-DQB1
Antigen processing and presentationhsa046126.042HLA-DQA1, HLA-DQB1
Systemic lupus erythematosushsa053225.952HLA-DQA1, HLA-DQB1
Tuberculosishsa051525.172HLA-DQA1, HLA-DQB1
Toxoplasmosishsa051455.712HLA-DQA1, HLA-DQB1
Allograft rejectionhsa053306.912HLA-DQA1, HLA-DQB1
Graft-versus-host diseasehsa053326.842HLA-DQA1, HLA-DQB1
Intestinal immune network for IgA productionhsa046726.792HLA-DQA1, HLA-DQB1
Leishmaniasishsa051406.322HLA-DQA1, HLA-DQB1
Staphylococcus aureus infectionhsa051506.642HLA-DQA1, HLA-DQB1
Phagosomehsa041455.272HLA-DQA1, HLA-DQB1
Epstein-Barr virus infectionhsa051694.972HLA-DQA1, HLA-DQB1
Asthmahsa053107.342HLA-DQA1, HLA-DQB1
Influenza Ahsa051645.212HLA-DQA1, HLA-DQB1
Type I diabetes mellitushsa049406.792HLA-DQA1, HLA-DQB1
HTLV-I infectionhsa051664.592HLA-DQA1, HLA-DQB1
Viral myocarditishsa054166.452HLA-DQA1, HLA-DQB1
Herpes simplex infectionhsa051685.082HLA-DQA1, HLA-DQB1

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.003CTLA4, HLA-DQA1, HLA-DQB1
Inflammatory bowel disease (IBD) (hsa05321) -6.430.014HLA-DQA1, HLA-DQB1
Leishmaniasis (hsa05140) -6.320.016HLA-DQA1, HLA-DQB1
Systemic lupus erythematosus (hsa05322) -5.950.028HLA-DQA1, HLA-DQB1
Rheumatoid arthritis (hsa05323) -6.050.002CTLA4, HLA-DQA1, HLA-DQB1
Autoimmune thyroid disease (hsa05320) -6.620.0CTLA4, HLA-DQA1, HLA-DQB1
Toxoplasmosis (hsa05145) -5.710.039HLA-DQA1, HLA-DQB1
Allograft rejection (hsa05330) -6.910.015HLA-DQA1, HLA-DQB1
Graft-versus-host disease (hsa05332) -6.840.018HLA-DQA1, HLA-DQB1
Intestinal immune network for IgA production (hsa04672) -6.790.031HLA-DQA1, HLA-DQB1
Cell adhesion molecules (CAMs) (hsa04514) -5.360.012CTLA4, HLA-DQA1, HLA-DQB1
Antigen processing and presentation (hsa04612) -6.040.024HLA-DQA1, HLA-DQB1
Staphylococcus aureus infection (hsa05150) -6.640.011HLA-DQA1, HLA-DQB1
Asthma (hsa05310) -7.340.004HLA-DQA1, HLA-DQB1
Type I diabetes mellitus (hsa04940) -6.790.009CTLA4, HLA-DQA1, HLA-DQB1
Viral myocarditis (hsa05416) -6.450.014HLA-DQA1, HLA-DQB1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.374CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
Costimulation by the CD28 familyR-HSA-3888416.563CTLA4, HLA-DQA1, HLA-DQB1
Adaptive Immune SystemR-HSA-12802183.193CTLA4, HLA-DQA1, HLA-DQB1
Generation of second messenger moleculesR-HSA-2024337.342HLA-DQA1, HLA-DQB1
PD-1 signalingR-HSA-3899487.622HLA-DQA1, HLA-DQB1
Translocation of ZAP-70 to Immunological synapseR-HSA-2024307.812HLA-DQA1, HLA-DQB1
Downstream TCR signalingR-HSA-2024247.012HLA-DQA1, HLA-DQB1
Phosphorylation of CD3 and TCR zeta chainsR-HSA-2024277.732HLA-DQA1, HLA-DQB1
Cytokine Signaling in Immune systemR-HSA-12802153.742HLA-DQA1, HLA-DQB1
Interferon gamma signalingR-HSA-8773005.672HLA-DQA1, HLA-DQB1
MHC class II antigen presentationR-HSA-21322956.012HLA-DQA1, HLA-DQB1
Interferon SignalingR-HSA-9135314.952HLA-DQA1, HLA-DQB1
TCR signalingR-HSA-2024036.642HLA-DQA1, HLA-DQB1

NET-GE enrichment

Term New enriched termICP valueGenes
Generation of second messenger molecules (R-HSA-202433) -7.340.005HLA-DQA1, HLA-DQB1
PD-1 signaling (R-HSA-389948) -7.620.007HLA-DQA1, HLA-DQB1
Translocation of ZAP-70 to Immunological synapse (R-HSA-202430) -7.810.002HLA-DQA1, HLA-DQB1
Downstream TCR signaling (R-HSA-202424) -7.010.007HLA-DQA1, HLA-DQB1
Phosphorylation of CD3 and TCR zeta chains (R-HSA-202427) -7.730.003HLA-DQA1, HLA-DQB1
Immune System (R-HSA-168256) -2.370.029CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
Interferon gamma signaling (R-HSA-877300) -5.670.047HLA-DQA1, HLA-DQB1
MHC class II antigen presentation (R-HSA-2132295) -6.010.03HLA-DQA1, HLA-DQB1
Costimulation by the CD28 family (R-HSA-388841) -6.560.0CTLA4, HLA-DQA1, HLA-DQB1
TCR signaling (R-HSA-202403) -6.640.012HLA-DQA1, HLA-DQB1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
cation binding (GO:0043169) 1.42MYO9B, HLA-DQB1
peptide binding (GO:0042277) 4.222HLA-DQA1, HLA-DQB1
antigen binding (GO:0003823) 5.022HLA-DQA1, HLA-DQB1
MHC class II receptor activity (GO:0032395) 7.12HLA-DQA1, HLA-DQB1
peptide antigen binding (GO:0042605) 6.182HLA-DQA1, HLA-DQB1
amide binding (GO:0033218) 4.142HLA-DQA1, HLA-DQB1
ion binding (GO:0043167) 1.362MYO9B, HLA-DQB1
molecular transducer activity (GO:0060089) 2.322HLA-DQA1, HLA-DQB1
transmembrane signaling receptor activity (GO:0004888) 2.572HLA-DQA1, HLA-DQB1
protein binding (GO:0005515) 0.462CTLA4, MYO9B
signal transducer activity (GO:0004871) 2.282HLA-DQA1, HLA-DQB1
signaling receptor activity (GO:0038023) 2.492HLA-DQA1, HLA-DQB1
metal ion binding (GO:0046872) 1.412MYO9B, HLA-DQB1
transmembrane receptor activity (GO:0099600) 2.532HLA-DQA1, HLA-DQB1
receptor activity (GO:0004872) 2.322HLA-DQA1, HLA-DQB1

NET-GE enrichment

Term New enriched termICP valueGenes
MHC class II receptor activity (GO:0032395) -7.10.0HLA-DQA1, HLA-DQB1
peptide antigen binding (GO:0042605) -6.180.015HLA-DQA1, HLA-DQB1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of response to stimulus (GO:0048583) 1.544CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
regulation of cellular process (GO:0050794) 0.54CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
biological regulation (GO:0065007) 0.394CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
signal transduction (GO:0007165) 1.284CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
cell surface receptor signaling pathway (GO:0007166) 2.094CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
regulation of biological process (GO:0050789) 0.454CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
regulation of cell activation (GO:0050865) 3.533CTLA4, HLA-DQA1, HLA-DQB1
regulation of cell adhesion (GO:0030155) 3.273CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of response to stimulus (GO:0048584) 2.183CTLA4, HLA-DQA1, HLA-DQB1
regulation of T cell activation (GO:0050863) 4.053CTLA4, HLA-DQA1, HLA-DQB1
regulation of cell-cell adhesion (GO:0022407) 3.793CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of cell-cell adhesion (GO:0022409) 4.233CTLA4, HLA-DQA1, HLA-DQB1
regulation of lymphocyte activation (GO:0051249) 3.733CTLA4, HLA-DQA1, HLA-DQB1
immune response-regulating signaling pathway (GO:0002764) 3.723CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of cell adhesion (GO:0045785) 3.793CTLA4, HLA-DQA1, HLA-DQB1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.963CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.353CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of immune system process (GO:0002684) 2.963CTLA4, HLA-DQA1, HLA-DQB1
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.063CTLA4, HLA-DQA1, HLA-DQB1
regulation of immune system process (GO:0002682) 2.53CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of biological process (GO:0048518) 1.23CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of cell activation (GO:0050867) 3.973CTLA4, HLA-DQA1, HLA-DQB1
T cell costimulation (GO:0031295) 5.353CTLA4, HLA-DQA1, HLA-DQB1
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013CTLA4, HLA-DQA1, HLA-DQB1
antigen receptor-mediated signaling pathway (GO:0050851) 4.433CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of T cell activation (GO:0050870) 4.393CTLA4, HLA-DQA1, HLA-DQB1
immune response-activating signal transduction (GO:0002757) 3.83CTLA4, HLA-DQA1, HLA-DQB1
immune response (GO:0006955) 2.863CTLA4, HLA-DQA1, HLA-DQB1
regulation of immune response (GO:0050776) 2.983CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of lymphocyte activation (GO:0051251) 4.073CTLA4, HLA-DQA1, HLA-DQB1
response to stimulus (GO:0050896) 1.223CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of immune response (GO:0050778) 3.43CTLA4, HLA-DQA1, HLA-DQB1
immune system process (GO:0002376) 2.293CTLA4, HLA-DQA1, HLA-DQB1
regulation of leukocyte activation (GO:0002694) 3.63CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of leukocyte activation (GO:0002696) 4.03CTLA4, HLA-DQA1, HLA-DQB1
activation of immune response (GO:0002253) 3.673CTLA4, HLA-DQA1, HLA-DQB1
lymphocyte costimulation (GO:0031294) 5.333CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of cellular process (GO:0048522) 1.33CTLA4, HLA-DQA1, HLA-DQB1
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) 5.142HLA-DQA1, HLA-DQB1
antigen processing and presentation (GO:0019882) 4.362HLA-DQA1, HLA-DQB1
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592HLA-DQA1, HLA-DQB1
cytokine-mediated signaling pathway (GO:0019221) 3.62HLA-DQA1, HLA-DQB1
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) 5.212HLA-DQA1, HLA-DQB1
cellular process (GO:0009987) 0.262CTLA4, MYO9B
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632HLA-DQA1, HLA-DQB1
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) 5.192HLA-DQA1, HLA-DQB1
T cell receptor signaling pathway (GO:0050852) 4.712HLA-DQA1, HLA-DQB1
interferon-gamma-mediated signaling pathway (GO:0060333) 5.482HLA-DQA1, HLA-DQB1
adaptive immune response (GO:0002250) 4.432CTLA4, HLA-DQB1
antigen processing and presentation of peptide antigen (GO:0048002) 4.562HLA-DQA1, HLA-DQB1

NET-GE enrichment

Term New enriched termICP valueGenes
antigen receptor-mediated signaling pathway (GO:0050851) -4.430.0CTLA4, HLA-DQA1, HLA-DQB1
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) -5.190.047HLA-DQA1, HLA-DQB1
immune response-activating signal transduction (GO:0002757) -3.80.014CTLA4, HLA-DQA1, HLA-DQB1
immune response-regulating signaling pathway (GO:0002764) -3.720.026CTLA4, HLA-DQA1, HLA-DQB1
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) -5.210.046HLA-DQA1, HLA-DQB1
positive regulation of lymphocyte activation (GO:0051251) -4.070.003CTLA4, HLA-DQA1, HLA-DQB1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.015CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of cell activation (GO:0050867) -3.970.003CTLA4, HLA-DQA1, HLA-DQB1
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.006CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of immune response (GO:0050778) -3.40.04CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of T cell activation (GO:0050870) -4.390.001CTLA4, HLA-DQA1, HLA-DQB1
immune system process (GO:0002376) -2.290.027CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
regulation of leukocyte activation (GO:0002694) -3.60.01CTLA4, HLA-DQA1, HLA-DQB1
regulation of cell activation (GO:0050865) -3.530.012CTLA4, HLA-DQA1, HLA-DQB1
regulation of lymphocyte activation (GO:0051249) -3.730.007CTLA4, HLA-DQA1, HLA-DQB1
regulation of T cell activation (GO:0050863) -4.050.003CTLA4, HLA-DQA1, HLA-DQB1
activation of immune response (GO:0002253) -3.670.019CTLA4, HLA-DQA1, HLA-DQB1
positive regulation of leukocyte activation (GO:0002696) -4.00.003CTLA4, HLA-DQA1, HLA-DQB1
T cell costimulation (GO:0031295) -5.350.001CTLA4, HLA-DQA1, HLA-DQB1
lymphocyte costimulation (GO:0031294) -5.330.001CTLA4, HLA-DQA1, HLA-DQB1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane (GO:0016020) 0.684CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
cell part (GO:0044464) 0.114CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
intracellular organelle (GO:0043229) 0.514CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
cytoplasmic part (GO:0044444) 0.824CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
intracellular part (GO:0044424) 0.284CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
organelle (GO:0043226) 0.44CTLA4, HLA-DQA1, MYO9B, HLA-DQB1
protein complex (GO:0043234) 1.513HLA-DQA1, MYO9B, HLA-DQB1
Golgi apparatus (GO:0005794) 2.73CTLA4, HLA-DQA1, HLA-DQB1
macromolecular complex (GO:0032991) 1.353HLA-DQA1, MYO9B, HLA-DQB1
intracellular membrane-bounded organelle (GO:0043231) 0.63CTLA4, HLA-DQA1, HLA-DQB1
membrane-bounded organelle (GO:0043227) 0.473CTLA4, HLA-DQA1, HLA-DQB1
integral component of membrane (GO:0016021) 1.143CTLA4, HLA-DQA1, HLA-DQB1
intracellular organelle part (GO:0044446) 0.813HLA-DQA1, MYO9B, HLA-DQB1
organelle part (GO:0044422) 0.793HLA-DQA1, MYO9B, HLA-DQB1
plasma membrane (GO:0005886) 1.393CTLA4, HLA-DQA1, HLA-DQB1
membrane part (GO:0044425) 0.953CTLA4, HLA-DQA1, HLA-DQB1
plasma membrane part (GO:0044459) 1.953CTLA4, HLA-DQA1, HLA-DQB1
intrinsic component of membrane (GO:0031224) 1.133CTLA4, HLA-DQA1, HLA-DQB1
lytic vacuole (GO:0000323) 3.892HLA-DQA1, HLA-DQB1
endoplasmic reticulum (GO:0005783) 2.562HLA-DQA1, HLA-DQB1
endoplasmic reticulum membrane (GO:0005789) 2.952HLA-DQA1, HLA-DQB1
integral component of endoplasmic reticulum membrane (GO:0030176) 5.012HLA-DQA1, HLA-DQB1
intrinsic component of plasma membrane (GO:0031226) 2.532CTLA4, HLA-DQA1
intrinsic component of endoplasmic reticulum membrane (GO:0031227) 4.972HLA-DQA1, HLA-DQB1
endosome membrane (GO:0010008) 3.832HLA-DQA1, HLA-DQB1
clathrin-coated vesicle membrane (GO:0030665) 5.62HLA-DQA1, HLA-DQB1
plasma membrane protein complex (GO:0098797) 3.552HLA-DQA1, HLA-DQB1
endocytic vesicle membrane (GO:0030666) 4.822HLA-DQA1, HLA-DQB1
organelle membrane (GO:0031090) 1.972HLA-DQA1, HLA-DQB1
coated vesicle membrane (GO:0030662) 5.02HLA-DQA1, HLA-DQB1
vacuole (GO:0005773) 2.922HLA-DQA1, HLA-DQB1
whole membrane (GO:0098805) 2.852HLA-DQA1, HLA-DQB1
clathrin-coated endocytic vesicle membrane (GO:0030669) 6.092HLA-DQA1, HLA-DQB1
Golgi apparatus part (GO:0044431) 3.02HLA-DQA1, HLA-DQB1
vacuolar membrane (GO:0005774) 3.452HLA-DQA1, HLA-DQB1
cytoplasmic vesicle part (GO:0044433) 3.412HLA-DQA1, HLA-DQB1
endoplasmic reticulum part (GO:0044432) 2.732HLA-DQA1, HLA-DQB1
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) 6.432HLA-DQA1, HLA-DQB1
vacuolar part (GO:0044437) 3.262HLA-DQA1, HLA-DQB1
perinuclear region of cytoplasm (GO:0048471) 3.352CTLA4, MYO9B
vesicle membrane (GO:0012506) 3.632HLA-DQA1, HLA-DQB1
bounding membrane of organelle (GO:0098588) 2.392HLA-DQA1, HLA-DQB1
lysosomal membrane (GO:0005765) 4.192HLA-DQA1, HLA-DQB1
transport vesicle membrane (GO:0030658) 4.862HLA-DQA1, HLA-DQB1
cytoplasmic vesicle membrane (GO:0030659) 3.672HLA-DQA1, HLA-DQB1
trans-Golgi network membrane (GO:0032588) 5.42HLA-DQA1, HLA-DQB1
integral component of plasma membrane (GO:0005887) 2.572CTLA4, HLA-DQA1
ER to Golgi transport vesicle membrane (GO:0012507) 5.812HLA-DQA1, HLA-DQB1
MHC protein complex (GO:0042611) 6.432HLA-DQA1, HLA-DQB1
MHC class II protein complex (GO:0042613) 6.812HLA-DQA1, HLA-DQB1
Golgi membrane (GO:0000139) 3.282HLA-DQA1, HLA-DQB1
lysosome (GO:0005764) 3.892HLA-DQA1, HLA-DQB1
membrane protein complex (GO:0098796) 2.842HLA-DQA1, HLA-DQB1
endosomal part (GO:0044440) 3.732HLA-DQA1, HLA-DQB1
endosome (GO:0005768) 3.252HLA-DQA1, HLA-DQB1
lytic vacuole membrane (GO:0098852) 4.192HLA-DQA1, HLA-DQB1

NET-GE enrichment

Term New enriched termICP valueGenes
clathrin-coated vesicle membrane (GO:0030665) -5.60.005HLA-DQA1, HLA-DQB1
MHC protein complex (GO:0042611) -6.430.017HLA-DQA1, HLA-DQB1
MHC class II protein complex (GO:0042613) -6.810.001HLA-DQA1, HLA-DQB1
endocytic vesicle membrane (GO:0030666) -4.820.041HLA-DQA1, HLA-DQB1
coated vesicle membrane (GO:0030662) -5.00.026HLA-DQA1, HLA-DQB1
clathrin-coated endocytic vesicle membrane (GO:0030669) -6.090.002HLA-DQA1, HLA-DQB1
trans-Golgi network membrane (GO:0032588) -5.40.003HLA-DQA1, HLA-DQB1
transport vesicle membrane (GO:0030658) -4.860.021HLA-DQA1, HLA-DQB1
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) -6.430.017HLA-DQA1, HLA-DQB1
integral component of endoplasmic reticulum membrane (GO:0030176) -5.010.029HLA-DQA1, HLA-DQB1
ER to Golgi transport vesicle membrane (GO:0012507) -5.810.012HLA-DQA1, HLA-DQB1