Disease table of DEMENTIA, LEWY BODY OMIM ID: 127750

Gene-disease associations table

GeneAssociated with DEMENTIA, LEWY BODY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SNCAClinVar, OMIM, HUMSAVARHGNC link4q22.12PS168600, 127750
SNCBClinVar, OMIMHGNC link5q35.21127750
GBAOMIMHGNC link1q227PS168600, 608013, 230900, 231005, 127750, 230800, 231000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SNCAYES1ZSCAN210
SNCBYES1MTF10
GBAYES1ETV40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SNCASNCBYes15GRK1, ADRBK1, PLK3, HSPA1A, PLK1, DNAAF2, DGUOK, GRK6, AKT1, TUBB3, NUFIP1, SNCA, TUBA1A, GRK5, APP
SNCAGBAYes10SKIV2L2, HSPA4, DHCR24, PARK2, ZCCHC8, HSP90AA1, FMR1, SNCA, INADL, NEDD4
SNCBGBANo1SNCA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SNCAGBAYesbinding2UBC, PARK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183GBA, SNCA, SNCB
protein binding (GO:0005515) 0.463GBA, SNCA, SNCB
cation binding (GO:0043169) 1.42SNCA, SNCB
tubulin binding (GO:0015631) 4.12SNCA, SNCB
lipase inhibitor activity (GO:0055102) 6.852SNCA, SNCB
metal ion binding (GO:0046872) 1.412SNCA, SNCB
enzyme regulator activity (GO:0030234) 2.852SNCA, SNCB
cytoskeletal protein binding (GO:0008092) 3.022SNCA, SNCB
catalytic activity (GO:0003824) 1.052GBA, SNCA
ion binding (GO:0043167) 1.362SNCA, SNCB
beta-tubulin binding (GO:0048487) 6.132SNCA, SNCB
phospholipase inhibitor activity (GO:0004859) 7.172SNCA, SNCB
calcium ion binding (GO:0005509) 3.172SNCA, SNCB
alpha-tubulin binding (GO:0043014) 6.372SNCA, SNCB
enzyme inhibitor activity (GO:0004857) 3.782SNCA, SNCB
molecular function regulator (GO:0098772) 2.512SNCA, SNCB

NET-GE enrichment

Term New enriched termICP valueGenes
alpha-tubulin binding (GO:0043014) -6.370.0SNCA, SNCB
beta-tubulin binding (GO:0048487) -6.130.001SNCA, SNCB
tubulin binding (GO:0015631) -4.10.037SNCA, SNCB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.263GBA, SNCA, SNCB
organonitrogen compound metabolic process (GO:1901564) 2.323GBA, SNCA, SNCB
regulation of catalytic activity (GO:0050790) 1.973GBA, SNCA, SNCB
cellular metabolic process (GO:0044237) 0.693GBA, SNCA, SNCB
regulation of biological process (GO:0050789) 0.453GBA, SNCA, SNCB
biological regulation (GO:0065007) 0.393GBA, SNCA, SNCB
organic substance metabolic process (GO:0071704) 0.633GBA, SNCA, SNCB
cell communication (GO:0007154) 3.043GBA, SNCA, SNCB
nitrogen compound metabolic process (GO:0006807) 1.133GBA, SNCA, SNCB
single-organism cellular process (GO:0044763) 0.653GBA, SNCA, SNCB
single-organism process (GO:0044699) 0.483GBA, SNCA, SNCB
metabolic process (GO:0008152) 0.583GBA, SNCA, SNCB
negative regulation of molecular function (GO:0044092) 2.743GBA, SNCA, SNCB
negative regulation of biological process (GO:0048519) 1.333GBA, SNCA, SNCB
regulation of molecular function (GO:0065009) 1.783GBA, SNCA, SNCB
regulation of cellular process (GO:0050794) 0.53GBA, SNCA, SNCB
negative regulation of catalytic activity (GO:0043086) 3.03GBA, SNCA, SNCB
negative regulation of cellular process (GO:0048523) 1.413GBA, SNCA, SNCB
organic hydroxy compound metabolic process (GO:1901615) 3.843GBA, SNCA, SNCB
regulation of phosphate metabolic process (GO:0019220) 2.352GBA, SNCA
regulation of primary metabolic process (GO:0080090) 1.082GBA, SNCA
regulation of metabolic process (GO:0019222) 1.022GBA, SNCA
negative regulation of response to stimulus (GO:0048585) 2.522GBA, SNCA
regulation of response to stimulus (GO:0048583) 1.542GBA, SNCA
regulation of neuron apoptotic process (GO:0043523) 4.472SNCA, SNCB
negative regulation of neuron apoptotic process (GO:0043524) 4.822SNCA, SNCB
small molecule metabolic process (GO:0044281) 2.382GBA, SNCA
cellular component organization or biogenesis (GO:0071840) 1.222SNCA, SNCB
single-organism metabolic process (GO:0044710) 1.632GBA, SNCA
negative regulation of macromolecule metabolic process (GO:0010605) 2.012GBA, SNCA
positive regulation of macromolecule metabolic process (GO:0010604) 1.812GBA, SNCA
negative regulation of signal transduction (GO:0009968) 2.752GBA, SNCA
regulation of signal transduction (GO:0009966) 1.842GBA, SNCA
cellular response to organic substance (GO:0071310) 2.782GBA, SNCA
positive regulation of biological process (GO:0048518) 1.22GBA, SNCA
regulation of macromolecule metabolic process (GO:0060255) 1.082GBA, SNCA
negative regulation of cell death (GO:0060548) 2.952SNCA, SNCB
regulation of protein kinase activity (GO:0045859) 3.152GBA, SNCA
regulation of proteolysis (GO:0030162) 3.22GBA, SNCA
response to organic substance (GO:0010033) 2.22GBA, SNCA
regulation of phosphorylation (GO:0042325) 2.52GBA, SNCA
single organism signaling (GO:0044700) 3.252SNCA, SNCB
negative regulation of phosphorylation (GO:0042326) 3.72GBA, SNCA
single-multicellular organism process (GO:0044707) 1.782GBA, SNCA
organonitrogen compound biosynthetic process (GO:1901566) 2.852GBA, SNCA
cellular biosynthetic process (GO:0044249) 1.372GBA, SNCA
regulation of autophagy (GO:0010506) 4.212GBA, SNCA
chemical homeostasis (GO:0048878) 2.972GBA, SNCA
anterograde trans-synaptic signaling (GO:0098916) 3.982SNCA, SNCB
cellular response to stress (GO:0033554) 2.512GBA, SNCA
positive regulation of catabolic process (GO:0009896) 3.942GBA, SNCA
regulation of catabolic process (GO:0009894) 3.522GBA, SNCA
negative regulation of metabolic process (GO:0009892) 1.932GBA, SNCA
positive regulation of metabolic process (GO:0009893) 1.742GBA, SNCA
synapse organization (GO:0050808) 4.872SNCA, SNCB
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582GBA, SNCA
regulation of apoptotic process (GO:0042981) 2.52SNCA, SNCB
lipid metabolic process (GO:0006629) 2.682GBA, SNCA
organic substance biosynthetic process (GO:1901576) 1.342GBA, SNCA
regulation of kinase activity (GO:0043549) 3.072GBA, SNCA
cellular component organization (GO:0016043) 1.242SNCA, SNCB
organic cyclic compound metabolic process (GO:1901360) 1.262SNCA, SNCB
regulation of biological quality (GO:0065008) 1.682GBA, SNCA
response to cytokine (GO:0034097) 3.842GBA, SNCA
cellular response to stimulus (GO:0051716) 1.972GBA, SNCA
catecholamine metabolic process (GO:0006584) 6.022SNCA, SNCB
response to stress (GO:0006950) 1.82GBA, SNCA
regulation of neuron death (GO:1901214) 4.192SNCA, SNCB
negative regulation of neuron death (GO:1901215) 4.572SNCA, SNCB
single-organism developmental process (GO:0044767) 1.492GBA, SNCA
response to stimulus (GO:0050896) 1.222GBA, SNCA
positive regulation of protein modification process (GO:0031401) 2.72GBA, SNCA
regulation of transferase activity (GO:0051338) 2.882GBA, SNCA
organic hydroxy compound biosynthetic process (GO:1901617) 4.982GBA, SNCA
synaptic signaling (GO:0099536) 3.982SNCA, SNCB
trans-synaptic signaling (GO:0099537) 3.982SNCA, SNCB
catechol-containing compound metabolic process (GO:0009712) 6.022SNCA, SNCB
negative regulation of signaling (GO:0023057) 2.652GBA, SNCA
signaling (GO:0023052) 3.252SNCA, SNCB
negative regulation of cell communication (GO:0010648) 2.662GBA, SNCA
cellular response to chemical stimulus (GO:0070887) 2.572GBA, SNCA
regulation of signaling (GO:0023051) 1.722GBA, SNCA
regulation of cell communication (GO:0010646) 1.732GBA, SNCA
response to organic cyclic compound (GO:0014070) 3.072GBA, SNCA
response to endogenous stimulus (GO:0009719) 2.792GBA, SNCA
negative regulation of protein metabolic process (GO:0051248) 2.822GBA, SNCA
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GBA, SNCA
negative regulation of phosphorus metabolic process (GO:0010563) 3.452GBA, SNCA
regulation of protein metabolic process (GO:0051246) 1.932GBA, SNCA
positive regulation of protein metabolic process (GO:0051247) 2.432GBA, SNCA
positive regulation of cellular protein metabolic process (GO:0032270) 2.492GBA, SNCA
regulation of protein modification process (GO:0031399) 2.322GBA, SNCA
developmental process (GO:0032502) 1.362GBA, SNCA
multicellular organismal process (GO:0032501) 1.452GBA, SNCA
positive regulation of cellular catabolic process (GO:0031331) 4.152GBA, SNCA
cellular aromatic compound metabolic process (GO:0006725) 1.32SNCA, SNCB
dopamine metabolic process (GO:0042417) 6.512SNCA, SNCB
phenol-containing compound metabolic process (GO:0018958) 5.332SNCA, SNCB
cellular lipid metabolic process (GO:0044255) 2.922GBA, SNCA
negative regulation of cellular protein metabolic process (GO:0032269) 2.882GBA, SNCA
regulation of cellular protein metabolic process (GO:0032268) 1.992GBA, SNCA
positive regulation of proteolysis (GO:0045862) 3.862GBA, SNCA
negative regulation of protein modification process (GO:0031400) 3.42GBA, SNCA
regulation of cellular catabolic process (GO:0031329) 3.832GBA, SNCA
positive regulation of cellular metabolic process (GO:0031325) 1.812GBA, SNCA
negative regulation of cellular metabolic process (GO:0031324) 2.012GBA, SNCA
regulation of cellular metabolic process (GO:0031323) 1.072GBA, SNCA
homeostatic process (GO:0042592) 2.612GBA, SNCA
regulation of cell death (GO:0010941) 2.432SNCA, SNCB
response to lipid (GO:0033993) 3.112GBA, SNCA
regulation of programmed cell death (GO:0043067) 2.492SNCA, SNCB
negative regulation of apoptotic process (GO:0043066) 3.042SNCA, SNCB
negative regulation of programmed cell death (GO:0043069) 3.022SNCA, SNCB
response to external stimulus (GO:0009605) 2.552GBA, SNCA
positive regulation of phosphate metabolic process (GO:0045937) 2.782GBA, SNCA
negative regulation of phosphate metabolic process (GO:0045936) 3.452GBA, SNCA
regulation of phosphorus metabolic process (GO:0051174) 2.352GBA, SNCA
biosynthetic process (GO:0009058) 1.322GBA, SNCA
chemical synaptic transmission (GO:0007268) 3.982SNCA, SNCB
cell-cell signaling (GO:0007267) 3.352SNCA, SNCB
response to chemical (GO:0042221) 1.982GBA, SNCA
response to oxygen-containing compound (GO:1901700) 2.572GBA, SNCA
primary metabolic process (GO:0044238) 0.692GBA, SNCA
negative regulation of protein phosphorylation (GO:0001933) 3.792GBA, SNCA
regulation of protein phosphorylation (GO:0001932) 2.572GBA, SNCA
positive regulation of cellular process (GO:0048522) 1.32GBA, SNCA

NET-GE enrichment

Term New enriched termICP valueGenes
catechol-containing compound metabolic process (GO:0009712) -6.020.008SNCA, SNCB
catecholamine metabolic process (GO:0006584) -6.020.008SNCA, SNCB
dopamine metabolic process (GO:0042417) -6.510.029SNCA, SNCB
phenol-containing compound metabolic process (GO:0018958) -5.330.031SNCA, SNCB
negative regulation of catalytic activity (GO:0043086) -3.00.035GBA, SNCA, SNCB
organic hydroxy compound metabolic process (GO:1901615) -3.840.008GBA, SNCA, SNCB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63GBA, SNCA, SNCB
cell part (GO:0044464) 0.113GBA, SNCA, SNCB
cytoplasmic part (GO:0044444) 0.823GBA, SNCA, SNCB
intracellular organelle part (GO:0044446) 0.813GBA, SNCA, SNCB
intracellular organelle (GO:0043229) 0.513GBA, SNCA, SNCB
intracellular part (GO:0044424) 0.283GBA, SNCA, SNCB
membrane-bounded organelle (GO:0043227) 0.473GBA, SNCA, SNCB
organelle (GO:0043226) 0.43GBA, SNCA, SNCB
organelle part (GO:0044422) 0.793GBA, SNCA, SNCB
lytic vacuole (GO:0000323) 3.892GBA, SNCA
site of polarized growth (GO:0030427) 4.852SNCA, SNCB
growth cone (GO:0030426) 4.892SNCA, SNCB
inclusion body (GO:0016234) 5.552SNCA, SNCB
synapse (GO:0045202) 3.582SNCA, SNCB
cytoplasm (GO:0005737) 1.012SNCA, SNCB
axon terminus (GO:0043679) 5.682SNCA, SNCB
neuron projection terminus (GO:0044306) 5.462SNCA, SNCB
vesicle (GO:0031982) 1.642GBA, SNCA
vacuole (GO:0005773) 2.922GBA, SNCA
whole membrane (GO:0098805) 2.852GBA, SNCA
membrane (GO:0016020) 0.682GBA, SNCA
mitochondrion (GO:0005739) 2.422SNCA, SNCB
membrane-bounded vesicle (GO:0031988) 1.712GBA, SNCA
neuron part (GO:0097458) 2.642SNCA, SNCB
synapse part (GO:0044456) 3.422SNCA, SNCB
presynapse (GO:0098793) 4.972SNCA, SNCB
Golgi apparatus (GO:0005794) 2.72SNCA, SNCB
bounding membrane of organelle (GO:0098588) 2.392GBA, SNCA
organelle membrane (GO:0031090) 1.972GBA, SNCA
terminal bouton (GO:0043195) 5.632SNCA, SNCB
cell projection part (GO:0044463) 2.972SNCA, SNCB
lysosome (GO:0005764) 3.892GBA, SNCA
nuclear part (GO:0044428) 1.552SNCA, SNCB
axon part (GO:0033267) 4.42SNCA, SNCB
extracellular region part (GO:0044421) 1.572GBA, SNCA

NET-GE enrichment

Term New enriched termICP valueGenes
terminal bouton (GO:0043195) -5.630.016SNCA, SNCB
site of polarized growth (GO:0030427) -4.850.009SNCA, SNCB
growth cone (GO:0030426) -4.890.008SNCA, SNCB
inclusion body (GO:0016234) -5.550.002SNCA, SNCB
axon part (GO:0033267) -4.40.011SNCA, SNCB