Disease table of PARKINSON DISEASE OMIM ID: PS168600

Gene-disease associations table

Gene	Associated with PARKINSON DISEASE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
GIGYF2	ClinVar, OMIM, HUMSAVAR	HGNC link	2q37.1	1	PS168600
GBA	ClinVar, OMIM	HGNC link	1q22	7	PS168600, 608013, 230900, 231005, 127750, 230800, 231000
PODXL	ClinVar	HGNC link	7q32.3	1	PS168600
FBXO7	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.3	1	PS168600
PINK1	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.12	1	PS168600
HTRA2	ClinVar, OMIM, HUMSAVAR	HGNC link	2p13.1	1	PS168600
CHCHD2	ClinVar, OMIM	HGNC link	7p11.2	1	PS168600
LRRK2	ClinVar, OMIM, HUMSAVAR	HGNC link	12q12	1	PS168600
PARK7	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.23	1	PS168600
ATP13A2	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.13	1	PS168600
PARK2	ClinVar, OMIM, HUMSAVAR	HGNC link	6q26	4	PS168600, 167000, 607572, 211980
PLA2G6	ClinVar, OMIM, HUMSAVAR	HGNC link	22q13.1	2	PS168600, PS234200
SYNJ1	ClinVar, OMIM, HUMSAVAR	HGNC link	21q22.11	1	PS168600
DNAJC13	ClinVar, OMIM, HUMSAVAR	HGNC link	3q22.1	1	PS168600
DNAJC6	ClinVar, OMIM	HGNC link	1p31.3	1	PS168600
VPS13C	ClinVar, OMIM	HGNC link	15q22.2	1	PS168600
NR4A2	ClinVar	HGNC link	2q24.1	1	PS168600
ATXN8OS	ClinVar	HGNC link	13q21.33	2	PS168600, PS164400
UCHL1	ClinVar, OMIM, HUMSAVAR	HGNC link	4p13	2	PS168600, 615491
VPS35	ClinVar, OMIM, HUMSAVAR	HGNC link	16q11.2	1	PS168600
SNCAIP	ClinVar	HGNC link	5q23.2	1	PS168600
TBP	ClinVar, OMIM	HGNC link	6q27	2	PS168600, PS164400
EIF4G1	ClinVar, OMIM, HUMSAVAR	HGNC link	3q27.1	1	PS168600
GLUD2	ClinVar	HGNC link	Xq24	1	PS168600
ADH1C	OMIM	HGNC link	4q23	2	PS168600, 103780
MAPT	OMIM	HGNC link	17q21.31	5	PS168600, 600274, 601104, 172700, 260540
SNCA	ClinVar, OMIM, HUMSAVAR	HGNC link	4q22.1	2	PS168600, 127750
ATXN2	ClinVar, OMIM	HGNC link	12q24.12	3	PS164400, PS168600, PS105400
ATXN3	ClinVar	HGNC link	14q32.12	2	PS168600, PS164400
FGF20	ClinVar	HGNC link	8p22	2	PS168600, 615721

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
1p36	3	PARK7, PINK1, ATP13A2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
6q2	2	PARK2, TBP
1p3	4	PARK7, DNAJC6, PINK1, ATP13A2
22q1	2	FBXO7, PLA2G6
4q2	2	SNCA, ADH1C
3q2	2	EIF4G1, DNAJC13

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	4	PARK7, DNAJC6, PINK1, ATP13A2
2q	2	NR4A2, GIGYF2
6q	2	PARK2, TBP
3q	2	EIF4G1, DNAJC13
12q	2	ATXN2, LRRK2
4q	2	SNCA, ADH1C
22q	2	FBXO7, PLA2G6

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	ATXN2, LRRK2
22	2	FBXO7, PLA2G6
1	5	PARK7, DNAJC6, PINK1, ATP13A2, GBA
3	2	EIF4G1, DNAJC13
2	3	NR4A2, HTRA2, GIGYF2
4	3	UCHL1, SNCA, ADH1C
7	2	PODXL, CHCHD2
6	2	PARK2, TBP

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
NR4A2	YES	5	MMP1, CRH, CXCL8, APOM, SLC6A3	0
TBP	YES	13	CRP, BCL2, FUS, IGF1R, NF1, CDKN1A, IL6, PPBP, BDKRB1, MYC, FOS, LIN28B, APP	0

regulated gene	associated to this disease	# TFs	TFs
GBA	YES	1	ETV4
PODXL	YES	2	WT1, VDR
HTRA2	YES	1	ESR1
PARK2	YES	1	SIM2
TBP	YES	8	CREM, CDX1, BTAF1, TAF1, RELA, DR1, NFKB1, HNF4A
SNCA	YES	1	ZSCAN21
ATXN2	YES	2	ZNF350, ETS1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
GIGYF2	GBA	No	2	NTRK1, HSP90AA1
GIGYF2	FBXO7	No	1	XPO1
GIGYF2	PINK1	No	1	HSP90AA1
GIGYF2	HTRA2	No	2	APC, VCP
GIGYF2	LRRK2	No	3	AGO2, HSP90AA1, YWHAB
GIGYF2	PARK7	No	2	MCM2, TP53
GIGYF2	PARK2	No	6	PRPF6, TARDBP, VCP, HSP90AA1, ELAVL1, AURKB
GIGYF2	DNAJC13	No	2	NTRK1, LGR4
GIGYF2	NR4A2	No	1	ELAVL1
GIGYF2	UCHL1	No	4	NTRK1, SMN1, TP53, HSP90AA1
GIGYF2	VPS35	No	2	NTRK1, ELAVL1
GIGYF2	TBP	No	4	MCM2, HUWE1, ELAVL1, TP53
GIGYF2	EIF4G1	No	10	TARDBP, PABPC1, G3BP1, SIRT7, EIF3A, CCDC8, NTRK1, GAG, MCM2, LGR4
GIGYF2	GLUD2	No	1	MCM2
GIGYF2	MAPT	No	1	YWHAB
GIGYF2	SNCA	No	2	FXR1, HSP90AA1
GIGYF2	ATXN2	No	4	NTRK1, BMI1, TARDBP, PABPC1
GIGYF2	ATXN3	No	2	CDKN1A, VCP
GBA	FBXO7	No	2	HSPD1, PARK2
GBA	PINK1	No	4	HSPA4, SNCA, PARK2, HSP90AA1
GBA	HTRA2	No	1	PARK2
GBA	LRRK2	No	6	HSPA4, PARK2, HSP90AA1, ITCH, HSPD1, SNCA
GBA	PARK7	No	4	ATP5J, HSPA4, SNCA, PARK2
GBA	PARK2	Yes	8	HSP90B1, HSPA4, CCT3, PARK2, TCP1, HSP90AA1, HSPD1, SNCA
GBA	DNAJC13	No	2	NTRK1, ATP6V1B1
GBA	UCHL1	No	3	NTRK1, PARK2, HSP90AA1
GBA	VPS35	No	1	NTRK1
GBA	SNCAIP	No	2	SNCA, PARK2
GBA	EIF4G1	No	2	NTRK1, SKIV2L2
GBA	MAPT	No	4	RPS6KA3, SNCA, PARK2, HSPA4
GBA	SNCA	Yes	10	SKIV2L2, HSPA4, DHCR24, PARK2, ZCCHC8, HSP90AA1, FMR1, SNCA, INADL, NEDD4
GBA	ATXN2	No	2	NTRK1, PARK2
GBA	ATXN3	No	3	CANX, PARK2, ITCH
PODXL	PARK7	No	1	NXF1
PODXL	DNAJC13	No	1	FCN1
PODXL	UCHL1	No	1	CDK2
PODXL	VPS35	No	2	NXF1, CDK2
PODXL	MAPT	No	1	CDK2
PODXL	ATXN2	No	1	NXF1
FBXO7	PINK1	Yes	3	UBC, PARK2, PINK1
FBXO7	HTRA2	No	4	PARK2, BIRC2, TRAF2, PINK1
FBXO7	CHCHD2	No	1	SIRT1
FBXO7	LRRK2	No	3	HSPD1, PARK2, TRAF2
FBXO7	PARK7	No	2	PARK2, PINK1
FBXO7	PARK2	Yes	12	UBE2D2, PSME3, PSMB4, CUL1, PARK2, PSMA6, UBC, PSMB7, TRAF2, HSPD1, PSMA3, PINK1
FBXO7	NR4A2	No	1	COPS5
FBXO7	UCHL1	No	4	UBC, COPS5, PARK2, CDK6
FBXO7	SNCAIP	No	2	PARK2, PINK1
FBXO7	EIF4G1	No	1	TRAF2
FBXO7	MAPT	No	4	UBC, UBE2D2, PARK2, SIRT1
FBXO7	SNCA	No	4	UBC, PARK2, SRRT, PINK1
FBXO7	ATXN2	No	4	BCAT1, PARK2, RBFOX2, SHFM1
FBXO7	ATXN3	No	2	UBC, PARK2
PINK1	HTRA2	Yes	7	HSD17B10, PARK2, TUBB, TUBA1A, VIM, HTRA2, PINK1
PINK1	CHCHD2	No	1	TOMM40
PINK1	LRRK2	No	13	AKT1, MAP1B, DNM1L, HSPA4, PARK2, TUBB, CDC37, TUBA1A, VIM, HSP90AA1, HSP90AB1, PRKDC, SNCA
PINK1	PARK7	Yes	9	BCL2L1, MAP1B, HSPA4, PARK7, PARK2, TRAF6, PTEN, SNCA, PINK1
PINK1	PARK2	Yes	31	BCL2L1, BAG2, HSD17B10, PARK2, TOMM70A, HSPA1A, TOMM22, TOMM40, SNCAIP, VIM, HTRA2, HSP90AB1, PSMD1, PGAM5, PARK7, PSMD2, RHOT2, TUBA1A, SNCA, BCL2L2, PINK1, MCL1, DNM1L, FBXO7, HSP90AA1, PSMC6, RHOT1, UBE2M, HSPA4, TUBB, UBC
PINK1	DNAJC6	No	1	BAG2
PINK1	UCHL1	No	6	PARK2, HSP90AA1, TUBA1A, TRAF6, AKT1, UBC
PINK1	VPS35	No	1	TOLLIP
PINK1	SNCAIP	Yes	4	SNCA, PARK2, SNCAIP, PINK1
PINK1	EIF4G1	No	1	HTRA2
PINK1	MAPT	No	9	HSPA1A, HSPA4, PARK2, MARK2, TRAF6, TUBA1A, AKT1, UBC, SNCA
PINK1	SNCA	Yes	14	HSP90AA1, HSPA1A, AKT1, MAP1B, PARK2, PARK7, HSPA4, TRAF6, SNCAIP, TUBB, MAP1LC3A, UBC, SNCA, PINK1
PINK1	ATXN2	No	1	PARK2
PINK1	ATXN3	No	6	BCL2L1, PARK2, TUBB, TUBA1A, TRAF6, UBC
HTRA2	CHCHD2	No	1	KHSRP
HTRA2	LRRK2	No	6	PARK2, TUBB, TUBA1A, VIM, TRAF2, EEF1A1
HTRA2	PARK7	No	3	PIR, PARK2, PINK1
HTRA2	PARK2	Yes	14	TUBB6, OPA1, VCP, HSD17B10, PARK2, TUBB, TUBA1A, VIM, HTRA2, TRAF2, EEF1A1, TUBB7P, PINK1, CDK5
HTRA2	UCHL1	No	4	CDK1, PARK2, TUBA1A, CDK5
HTRA2	SNCAIP	No	2	PARK2, PINK1
HTRA2	EIF4G1	Yes	2	HTRA2, TRAF2
HTRA2	MAPT	No	6	MAPK11, PARK2, MAPK13, TUBA1A, HAX1, CDK5
HTRA2	SNCA	No	7	MAPK3, PARK2, TUBB, HAX1, EEF1A1, PINK1, ACTA1
HTRA2	ATXN2	No	1	PARK2
HTRA2	ATXN3	No	4	TUBA1A, PARK2, TUBB, VCP
CHCHD2	PARK2	No	4	TOMM40, C1QBP, REL, TCF4
CHCHD2	UCHL1	No	1	TRIM54
CHCHD2	VPS35	No	1	RPL24
CHCHD2	TBP	No	2	GOLGA2, REL
CHCHD2	MAPT	No	1	SIRT1
CHCHD2	ATXN3	No	1	TRIM54
LRRK2	PARK7	No	9	BAX, CASP8, MAP1B, PARK2, HSPA4, FADD, PPP2R1A, SNCA, STUB1
LRRK2	ATP13A2	No	4	RAB7A, HSPA8, RAB5A, LRP6
LRRK2	PARK2	Yes	30	RAC1, HSPA4, RPS8, YWHAE, TPM1, VIM, TUBB, HSP90AB1, STUB1, ACTA2, YWHAH, PSMD11, TUBA1C, TUBA1A, EEF1A1, HSPA9, LRRK2, DNM1L, HSP90AA1, BAG5, TRAF2, HSPD1, SNCA, DNAJA1, ACTBL2, HSPA8, PARK2, ACTB, TPM3, MAPT
LRRK2	SYNJ1	No	3	SH3GL1, CLTC, SH3GL2
LRRK2	DNAJC13	No	4	HSPA8, BAG5, CALM1, STUB1
LRRK2	DNAJC6	No	1	CLTC
LRRK2	UCHL1	No	5	PARK2, TUBA1A, HSPA8, HSP90AA1, AKT1
LRRK2	VPS35	No	2	RAB7A, H3F3A
LRRK2	SNCAIP	No	3	YWHAH, PARK2, SNCA
LRRK2	EIF4G1	No	3	IQGAP1, HERC2, TRAF2
LRRK2	MAPT	Yes	13	CALM1, LRRK2, HSPA4, MAPT, PARK2, TUBA1A, YWHAZ, AKT1, HSPA8, YWHAB, YWHAQ, SNCA, STUB1
LRRK2	SNCA	Yes	20	BAX, CALM1, MAP1B, LRRK2, DYNC1H1, HSPA4, MAPT, PARK2, RAB5A, TUBB, ACTB, BAG5, HSP90AA1, AKT1, CLTC, HSPA8, EEF1A1, YWHAQ, SNCA, STUB1
LRRK2	ATXN2	No	3	SH3GL3, PARK2, SH3GL2
LRRK2	ATXN3	No	7	TUBB4B, PARK2, TUBB, TUBA1A, ITCH, TK1, STUB1
PARK7	ATP13A2	No	1	HIPK1
PARK7	PARK2	Yes	11	BCL2L1, SUMO1, PINK1, HSPA4, PARK7, PARK2, SFPQ, NPM1, NDUFS3, SNCA, STUB1
PARK7	DNAJC13	No	2	NPM1, STUB1
PARK7	DNAJC6	No	1	HDAC1
PARK7	NR4A2	No	1	SFPQ
PARK7	UCHL1	No	4	UBE2I, PARK2, TRAF6, TP53
PARK7	VPS35	No	3	UNK, NXF1, ENO1
PARK7	SNCAIP	No	3	SNCA, PARK2, PINK1
PARK7	TBP	No	5	TP53, HDAC1, MCM2, UBE2I, AR
PARK7	EIF4G1	No	2	UNK, MCM2
PARK7	GLUD2	No	1	MCM2
PARK7	MAPT	No	6	BAG1, HSPA4, PARK2, TRAF6, SNCA, STUB1
PARK7	SNCA	Yes	10	BAX, MAP1B, PARK2, PARK7, HSPA4, ND1, TRAF6, PINK1, SNCA, STUB1
PARK7	ATXN2	No	3	VHL, NXF1, PARK2
PARK7	ATXN3	No	7	BCL2L1, SUMO1, ANXA7, PARK2, TRAF6, PML, STUB1
ATP13A2	PARK2	No	4	PDIA6, SYT11, UBE2J2, HSPA8
ATP13A2	DNAJC13	No	1	HSPA8
ATP13A2	UCHL1	No	1	HSPA8
ATP13A2	VPS35	No	1	RAB7A
ATP13A2	MAPT	No	2	HDAC6, HSPA8
ATP13A2	SNCA	No	2	RAB5A, HSPA8
ATP13A2	ATXN3	No	1	HDAC6
PARK2	DNAJC13	No	4	BAG5, HSPA8, NPM1, STUB1
PARK2	DNAJC6	No	1	BAG2
PARK2	NR4A2	No	2	SFPQ, ELAVL1
PARK2	UCHL1	Yes	11	HSPA8, EGFR, PARK2, TUBA1A, HSP90AA1, RPTOR, CTNNB1, UBC, CDK5, CBX1, APP
PARK2	VPS35	No	5	SLC11A2, ELAVL1, APP, MCM7, ARRB2
PARK2	SNCAIP	Yes	7	PSMC4, YWHAH, PARK2, SNCAIP, ARIH1, SNCA, PINK1
PARK2	TBP	No	8	RUVBL1, RUVBL2, PSMC2, HCVGP1, DDX5, ELAVL1, DYRK1A, REL
PARK2	EIF4G1	No	8	HNRNPD, TARDBP, EIF4B, PSMC3, HTRA2, TRAF2, HSPA5, AIMP2
PARK2	MAPT	Yes	22	HSPA1A, HSPA4, EGFR, CDK5, PRKACA, APP, UBE2D2, PSMC2, MAPT, SYNCRIP, TUBA1A, STUB1, SNCA, SQSTM1, UBASH3B, LRRK2, TUBA4A, ABL1, HSPA8, CAMK2A, PARK2, UBC
PARK2	SNCA	Yes	39	HSPA1A, EGFR, HSPA4, PRDX1, MAPK1, SNCAIP, TUBB, SNRNP200, GBA, STUB1, VDAC2, TUBB1, PARK7, MAPT, PSMC3, DNAJB1, ARRB1, SLC6A3, HSPA1L, PINK1, LRRK2, GAPDH, HSP90AA1, BAG5, EEF1A1, SYN1, HSPA8, PRPF19, PARK2, ACTB, PLK1, SQSTM1, DYRK1A, UBC, VDAC1, FBXW7, APP, TUBG1, SNCA
PARK2	ATXN2	Yes	6	DDX5, TARDBP, DDX17, PARK2, CHGB, EGFR
PARK2	ATXN3	Yes	17	BCL2L1, PICK1, VCP, SUMO1, PSMC5, RAD23A, PARK2, UBE2L3, TUBB, TUBA1A, APP, RAD23B, UBC, STUB1, ATXN3, SQSTM1, XRCC6
PLA2G6	ATXN3	No	1	BAG3
SYNJ1	DNAJC6	No	1	CLTC
SYNJ1	SNCA	No	1	CLTC
SYNJ1	ATXN2	No	2	SH3KBP1, SH3GL2
DNAJC13	UCHL1	No	2	NTRK1, HSPA8
DNAJC13	VPS35	No	2	NTRK1, SNX1
DNAJC13	SNCAIP	No	1	GSK3B
DNAJC13	EIF4G1	No	3	NTRK1, CUL3, LGR4
DNAJC13	MAPT	No	4	CALM1, GSK3B, HSPA8, STUB1
DNAJC13	SNCA	No	5	HSPA8, BAG5, GSK3B, CALM1, STUB1
DNAJC13	ATXN2	No	2	NTRK1, CUL3
DNAJC13	ATXN3	No	2	GSK3B, STUB1
DNAJC6	TBP	No	1	HDAC1
DNAJC6	SNCA	No	1	CLTC
NR4A2	UCHL1	No	1	COPS5
NR4A2	VPS35	No	1	ELAVL1
NR4A2	TBP	No	4	SMARCA2, SIN3A, RXRA, ELAVL1
UCHL1	VPS35	No	3	NTRK1, APP, CDK2
UCHL1	SNCAIP	No	1	PARK2
UCHL1	TBP	No	3	UBE2I, TP53, MDM2
UCHL1	EIF4G1	No	2	NTRK1, CUL7
UCHL1	MAPT	No	10	HSPA8, EGFR, CDK2, PARK2, TRAF6, TUBA1A, AKT1, UBC, CDK5, APP
UCHL1	SNCA	No	10	HSP90AA1, HSPA8, AKT1, PARK2, TRAF6, LAMP2, CDK4, EGFR, UBC, APP
UCHL1	ATXN2	No	3	NTRK1, PARK2, EGFR
UCHL1	ATXN3	No	9	USP21, NEDD8, PARK2, TRAF6, TUBA1A, TRIM54, TRIM63, UBC, APP
VPS35	TBP	No	1	ELAVL1
VPS35	EIF4G1	No	4	UNK, NTRK1, FN1, ITGA4
VPS35	GLUD2	No	2	SHMT2, MOV10
VPS35	MAPT	No	3	USP43, CDK2, APP
VPS35	SNCA	No	2	PSAP, APP
VPS35	ATXN2	No	3	NTRK1, NXF1, MOV10
VPS35	ATXN3	No	2	UBE4B, APP
SNCAIP	MAPT	No	6	CSNK2A1, PARK2, PIN1, SNCA, GSK3B, NUB1
SNCAIP	SNCA	Yes	11	SIAH2, CSNK2A1, PARK2, SIAH1, SNCAIP, PIN1, HERPUD1, GSK3B, HSPA5, PINK1, SNCA
SNCAIP	ATXN2	No	1	PARK2
SNCAIP	ATXN3	No	2	GSK3B, PARK2
TBP	EIF4G1	No	3	USP10, MCM2, ESR1
TBP	GLUD2	No	1	MCM2
TBP	MAPT	No	2	EP300, PSMC2
TBP	SNCA	No	2	DYRK1A, TAF7
TBP	ATXN2	No	1	DDX5
TBP	ATXN3	No	3	CREBBP, EP300, HAP1
EIF4G1	GLUD2	No	1	MCM2
EIF4G1	SNCA	No	3	NCBP1, SKIV2L2, PSMC3
EIF4G1	ATXN2	No	6	PABPC4, TARDBP, PABPC1, ISG15, NTRK1, CUL3
EIF4G1	ATXN3	No	1	MKNK1
GLUD2	ATXN2	No	1	MOV10
MAPT	SNCA	Yes	32	HSPA1A, PIN1, HSPA4, CSNK1D, DGUOK, EGFR, TUBA1B, STUB1, MAPK8, MAPT, TUBA1A, DNAAF2, APP, SNCA, YWHAZ, CALM1, LRRK2, TRAF6, CSNK1A1, HAX1, AKT1, SRC, FYN, GSK3B, FKBP4, HSPA8, CSNK2A1, PARK2, NUFIP1, SQSTM1, UBC, YWHAQ
MAPT	ATXN2	No	3	PARK2, BAG6, EGFR
MAPT	ATXN3	No	12	EP300, PARK2, HDAC6, TUBA1A, TRAF6, RPS6KA1, UBC, APP, SQSTM1, EWSR1, GSK3B, STUB1
SNCA	ATXN2	No	2	PARK2, EGFR
SNCA	ATXN3	No	10	PARK2, TUBB, UBC, TUBA1A, STUB1, TRAF6, SRI, GSK3B, APP, SQSTM1
ATXN2	ATXN3	No	1	PARK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PINK1	PARK2	Yes	0
PINK1	SNCA	No	1	PARK2
PARK2	SNCA	Yes	0
SNCAIP	SNCA	No	2	VPS52, TLG2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
GIGYF2	GBA	No	-	1	UBC
GIGYF2	PODXL	No	-	1	UBC
GIGYF2	FBXO7	No	-	1	UBC
GIGYF2	PINK1	No	-	1	UBC
GIGYF2	HTRA2	No	-	1	UBC
GIGYF2	LRRK2	No	-	1	UBC
GIGYF2	PARK7	No	-	1	UBC
GIGYF2	ATP13A2	No	-	1	UBC
GIGYF2	PARK2	No	-	1	UBC
GIGYF2	DNAJC13	No	-	1	UBC
GIGYF2	VPS13C	No	-	1	UBC
GIGYF2	UCHL1	No	-	1	UBC
GIGYF2	VPS35	No	-	1	UBC
GIGYF2	SNCAIP	No	-	1	UBC
GIGYF2	TBP	No	-	1	UBC
GIGYF2	EIF4G1	No	-	2	UBC, RQCD1
GIGYF2	GLUD2	No	-	1	UBC
GIGYF2	MAPT	No	-	1	UBC
GIGYF2	SNCA	No	-	1	UBC
GIGYF2	ATXN2	No	-	1	UBC
GIGYF2	ATXN3	No	-	1	UBC
GBA	PODXL	No	-	1	UBC
GBA	FBXO7	No	-	1	UBC
GBA	PINK1	No	-	3	UBC, SNCA, PARK2
GBA	HTRA2	No	-	2	UBC, PARK2
GBA	LRRK2	No	-	2	UBC, SNCA
GBA	PARK7	No	-	3	UBC, SNCA, PARK2
GBA	ATP13A2	No	-	1	UBC
GBA	PARK2	Yes	binding	2	UBC, SNCA
GBA	DNAJC13	No	-	1	UBC
GBA	VPS13C	No	-	1	UBC
GBA	UCHL1	No	-	2	UBC, SNCA
GBA	VPS35	No	-	1	UBC
GBA	SNCAIP	No	-	3	UBC, SNCA, PARK2
GBA	TBP	No	-	1	UBC
GBA	EIF4G1	No	-	1	UBC
GBA	GLUD2	No	-	1	UBC
GBA	MAPT	No	-	3	UBC, SNCA, PARK2
GBA	SNCA	Yes	binding	2	UBC, PARK2
GBA	ATXN2	No	-	1	UBC
GBA	ATXN3	No	-	2	UBC, PARK2
PODXL	FBXO7	No	-	1	UBC
PODXL	PINK1	No	-	1	UBC
PODXL	HTRA2	No	-	1	UBC
PODXL	LRRK2	No	-	2	UBC, SPAG9
PODXL	PARK7	No	-	1	UBC
PODXL	ATP13A2	No	-	1	UBC
PODXL	PARK2	No	-	1	UBC
PODXL	DNAJC13	No	-	1	UBC
PODXL	VPS13C	No	-	1	UBC
PODXL	UCHL1	No	-	1	UBC
PODXL	VPS35	No	-	1	UBC
PODXL	SNCAIP	No	-	1	UBC
PODXL	TBP	No	-	1	UBC
PODXL	EIF4G1	No	-	1	UBC
PODXL	GLUD2	No	-	1	UBC
PODXL	MAPT	No	-	1	UBC
PODXL	SNCA	No	-	1	UBC
PODXL	ATXN2	No	-	1	UBC
PODXL	ATXN3	No	-	1	UBC
FBXO7	PINK1	No	-	1	UBC
FBXO7	HTRA2	No	-	3	UBC, BIRC2, TRAF2
FBXO7	LRRK2	No	-	2	UBC, TRAF2
FBXO7	PARK7	No	-	1	UBC
FBXO7	ATP13A2	No	-	1	UBC
FBXO7	PARK2	No	-	3	UBC, CUL1, TRAF2
FBXO7	DNAJC13	No	-	1	UBC
FBXO7	VPS13C	No	-	1	UBC
FBXO7	UCHL1	No	-	1	UBC
FBXO7	VPS35	No	-	1	UBC
FBXO7	SNCAIP	No	-	1	UBC
FBXO7	TBP	No	-	1	UBC
FBXO7	EIF4G1	No	-	2	UBC, TRAF2
FBXO7	GLUD2	No	-	1	UBC
FBXO7	MAPT	No	-	1	UBC
FBXO7	SNCA	No	-	1	UBC
FBXO7	ATXN2	No	-	1	UBC
FBXO7	ATXN3	No	-	1	UBC
PINK1	HTRA2	Yes	binding	3	UBC, PARK2, AKT1
PINK1	LRRK2	No	-	8	HSP90AB1, HSPA4, CDC37, HSP90AA1, BAG5, AKT1, UBC, SNCA
PINK1	PARK7	Yes	binding	7	BCL2L1, HSPA4, PARK2, BECN1, AKT1, UBC, SNCA
PINK1	ATP13A2	No	-	1	UBC
PINK1	PARK2	Yes	binding	12	BCL2L1, RHOT1, BECN1, PARK7, HSPA4, SNCAIP, RHOT2, BAG5, HSP90AA1, UBC, SNCA, HTRA2
PINK1	PLA2G6	No	-	1	AKT1
PINK1	DNAJC13	No	-	1	UBC
PINK1	DNAJC6	No	-	1	BAG2
PINK1	VPS13C	No	-	1	UBC
PINK1	UCHL1	No	-	3	UBC, SNCA, HSP90AA1
PINK1	VPS35	No	-	1	UBC
PINK1	SNCAIP	Yes	binding	3	UBC, SNCA, PARK2
PINK1	TBP	No	-	1	UBC
PINK1	EIF4G1	No	-	1	UBC
PINK1	GLUD2	No	-	1	UBC
PINK1	MAPT	No	-	5	UBC, PARK2, SNCA, HSPA4, AKT1
PINK1	SNCA	Yes	binding	6	HSPA4, PARK7, PARK2, SNCAIP, AKT1, UBC
PINK1	ATXN2	No	-	1	UBC
PINK1	ATXN3	No	-	2	UBC, PARK2
HTRA2	LRRK2	No	-	3	UBC, TRAF2, AKT1
HTRA2	PARK7	No	-	4	UBC, PARK2, AKT1, PINK1
HTRA2	ATP13A2	No	-	1	UBC
HTRA2	PARK2	Yes	binding	4	UBC, CDK5, TRAF2, PINK1
HTRA2	PLA2G6	No	-	1	AKT1
HTRA2	SYNJ1	No	-	1	CDK5
HTRA2	DNAJC13	No	-	1	UBC
HTRA2	VPS13C	No	-	1	UBC
HTRA2	UCHL1	No	-	1	UBC
HTRA2	VPS35	No	-	1	UBC
HTRA2	SNCAIP	No	-	3	UBC, PARK2, PINK1
HTRA2	TBP	No	-	2	UBC, MAPK14
HTRA2	EIF4G1	No	-	2	UBC, TRAF2
HTRA2	GLUD2	No	-	1	UBC
HTRA2	MAPT	No	-	4	UBC, CDK5, PARK2, AKT1
HTRA2	SNCA	No	-	4	UBC, PARK2, AKT1, PINK1
HTRA2	ATXN2	No	-	2	UBC, CDK5
HTRA2	ATXN3	No	-	2	UBC, PARK2
CHCHD2	PARK2	No	-	1	C1QBP
LRRK2	PARK7	No	-	6	MAP1B, HSPA4, AKT1, UBC, SNCA, STUB1
LRRK2	ATP13A2	No	-	1	UBC
LRRK2	PARK2	No	-	9	HSPA8, SH3GL2, HSPA4, HSP90AA1, BAG5, TRAF2, UBC, SNCA, STUB1
LRRK2	PLA2G6	No	-	1	AKT1
LRRK2	SYNJ1	No	-	4	SH3GL1, SH3GL3, SH3GL2, CLTC
LRRK2	DNAJC13	No	-	1	UBC
LRRK2	DNAJC6	No	-	2	CLTC, HSPA8
LRRK2	VPS13C	No	-	1	UBC
LRRK2	UCHL1	No	-	4	UBC, SNCA, HSPA8, HSP90AA1
LRRK2	VPS35	No	-	1	UBC
LRRK2	SNCAIP	No	-	3	UBC, SNCA, GSK3B
LRRK2	TBP	No	-	2	UBC, POTEF
LRRK2	EIF4G1	No	-	7	HSPA8, TRAF2, EIF4EBP3, EIF4EBP1, UBC, PAK1, RPS15
LRRK2	GLUD2	No	-	1	UBC
LRRK2	MAPT	No	-	12	TUBB4B, HSPA8, GSK3B, HSPA4, UBC, TUBA4A, YWHAZ, AKT1, TUBB3, SNCA, YWHAQ, STUB1
LRRK2	SNCA	Yes	activation, binding	7	HSPA8, HSPA4, AKT1, UBC, TUBA1B, GSK3B, STUB1
LRRK2	ATXN2	No	-	3	UBC, SH3GL3, SH3GL2
LRRK2	ATXN3	No	-	3	UBC, GSK3B, STUB1
LRRK2	FGF20	No	-	5	YWHAE, YWHAH, YWHAG, YWHAB, YWHAZ
PARK7	ATP13A2	No	-	1	UBC
PARK7	PARK2	Yes	binding	8	BCL2L1, BCL2, HSPA4, BECN1, PINK1, UBC, SNCA, STUB1
PARK7	PLA2G6	No	-	1	AKT1
PARK7	DNAJC13	No	-	1	UBC
PARK7	VPS13C	No	-	1	UBC
PARK7	NR4A2	No	-	5	PITX3, AR, DRD2, TP53, TH
PARK7	UCHL1	No	-	4	UBC, SNCA, TP53, BCL2
PARK7	VPS35	No	-	1	UBC
PARK7	SNCAIP	No	-	4	UBC, SNCA, PARK2, PINK1
PARK7	TBP	No	-	5	UBC, AR, MTA3, MTA1, TP53
PARK7	EIF4G1	No	-	1	UBC
PARK7	GLUD2	No	-	1	UBC
PARK7	MAPT	No	-	6	HSPA4, PARK2, AKT1, UBC, SNCA, STUB1
PARK7	SNCA	Yes	binding	8	BAX, SUMO1, HSPA4, PARK2, PINK1, AKT1, UBC, STUB1
PARK7	ATXN2	No	-	1	UBC
PARK7	ATXN3	No	-	4	UBC, PARK2, STUB1, SUMO1
ATP13A2	PARK2	No	-	1	UBC
ATP13A2	DNAJC13	No	-	1	UBC
ATP13A2	VPS13C	No	-	1	UBC
ATP13A2	UCHL1	No	-	1	UBC
ATP13A2	VPS35	No	-	1	UBC
ATP13A2	SNCAIP	No	-	1	UBC
ATP13A2	TBP	No	-	1	UBC
ATP13A2	EIF4G1	No	-	1	UBC
ATP13A2	GLUD2	No	-	1	UBC
ATP13A2	MAPT	No	-	1	UBC
ATP13A2	SNCA	No	-	1	UBC
ATP13A2	ATXN2	No	-	1	UBC
ATP13A2	ATXN3	No	-	1	UBC
PARK2	SYNJ1	No	-	3	EPS15, CDK5, SH3GL2
PARK2	DNAJC13	No	-	1	UBC
PARK2	DNAJC6	No	-	2	ARRB1, HSPA8
PARK2	VPS13C	No	-	1	UBC
PARK2	UCHL1	No	-	6	HSPA8, BCL2, NEDD8, HSP90AA1, UBC, SNCA
PARK2	VPS35	No	-	1	UBC
PARK2	SNCAIP	Yes	activation, binding	3	UBC, SNCA, PINK1
PARK2	TBP	No	-	4	UBC, REL, PSMC5, PCNA
PARK2	EIF4G1	No	-	5	UBC, UBE2L6, HSPA8, RPS27A, TRAF2
PARK2	GLUD2	No	-	1	UBC
PARK2	MAPT	Yes	binding	7	HSPA8, HSPA4, ABL1, UBC, SNCA, CDK5, STUB1
PARK2	SNCA	Yes	activation, binding	13	HSPA8, PINK1, GAPDH, PARK7, HSPA4, APP, UBE2L3, UBC, SNCAIP, SLC6A3, GBA, MAPT, STUB1
PARK2	ATXN2	No	-	3	UBC, CDK5, SH3GL2
PARK2	ATXN3	Yes	binding	5	UBC, RPS27A, STUB1, NEDD8, VCP
PLA2G6	MAPT	No	-	1	AKT1
PLA2G6	SNCA	No	-	3	PRKCD, MAPK1, AKT1
SYNJ1	DNAJC6	No	-	3	CLTCL1, CLHC1, CLTC
SYNJ1	MAPT	No	-	4	PPP3CA, BIN1, DYRK1A, CDK5
SYNJ1	SNCA	No	-	1	DYRK1A
SYNJ1	ATXN2	No	-	3	CDK5, SH3GL3, SH3GL2
SYNJ1	FGF20	No	-	1	EGFR
DNAJC13	VPS13C	No	-	1	UBC
DNAJC13	UCHL1	No	-	1	UBC
DNAJC13	VPS35	No	-	2	UBC, SNX1
DNAJC13	SNCAIP	No	-	1	UBC
DNAJC13	TBP	No	-	1	UBC
DNAJC13	EIF4G1	No	-	1	UBC
DNAJC13	GLUD2	No	-	1	UBC
DNAJC13	MAPT	No	-	1	UBC
DNAJC13	SNCA	No	-	1	UBC
DNAJC13	ATXN2	No	-	1	UBC
DNAJC13	ATXN3	No	-	1	UBC
DNAJC6	UCHL1	No	-	1	HSPA8
DNAJC6	EIF4G1	No	-	1	HSPA8
DNAJC6	MAPT	No	-	1	HSPA8
DNAJC6	SNCA	No	-	1	HSPA8
VPS13C	UCHL1	No	-	1	UBC
VPS13C	VPS35	No	-	1	UBC
VPS13C	SNCAIP	No	-	1	UBC
VPS13C	TBP	No	-	1	UBC
VPS13C	EIF4G1	No	-	1	UBC
VPS13C	GLUD2	No	-	1	UBC
VPS13C	MAPT	No	-	1	UBC
VPS13C	SNCA	No	-	1	UBC
VPS13C	ATXN2	No	-	1	UBC
VPS13C	ATXN3	No	-	1	UBC
NR4A2	UCHL1	No	-	1	TP53
NR4A2	TBP	No	-	4	AR, ESR1, TP53, HNF4A
NR4A2	EIF4G1	No	-	1	SUMO2
NR4A2	MAPT	No	-	1	ESR1
UCHL1	VPS35	No	-	1	UBC
UCHL1	SNCAIP	No	-	2	UBC, SNCA
UCHL1	TBP	No	-	3	UBC, TP53, SPI1
UCHL1	EIF4G1	No	-	3	UBC, UBA52, HSPA8
UCHL1	GLUD2	No	-	1	UBC
UCHL1	MAPT	No	-	3	UBC, SNCA, HSPA8
UCHL1	SNCA	Yes	activation, binding	2	UBC, HSPA8
UCHL1	ATXN2	No	-	1	UBC
UCHL1	ATXN3	No	-	2	UBC, NEDD8
VPS35	SNCAIP	No	-	1	UBC
VPS35	TBP	No	-	1	UBC
VPS35	EIF4G1	No	-	1	UBC
VPS35	GLUD2	No	-	1	UBC
VPS35	MAPT	No	-	1	UBC
VPS35	SNCA	No	-	1	UBC
VPS35	ATXN2	No	-	1	UBC
VPS35	ATXN3	No	-	1	UBC
SNCAIP	TBP	No	-	1	UBC
SNCAIP	EIF4G1	No	-	1	UBC
SNCAIP	GLUD2	No	-	1	UBC
SNCAIP	MAPT	No	-	5	UBC, GSK3B, SNCA, PARK2, PIN1
SNCAIP	SNCA	Yes	binding	5	SIAH1, GSK3B, PARK2, UBC, PINK1
SNCAIP	ATXN2	No	-	1	UBC
SNCAIP	ATXN3	No	-	3	UBC, GSK3B, PARK2
TBP	EIF4G1	No	-	3	UBC, MYC, CNOT1
TBP	GLUD2	No	-	1	UBC
TBP	MAPT	No	-	4	UBC, MAPK8, JUN, ESR1
TBP	SNCA	No	-	1	UBC
TBP	ATXN2	No	-	1	UBC
TBP	ATXN3	No	-	2	UBC, CREBBP
EIF4G1	GLUD2	No	-	1	UBC
EIF4G1	MAPT	No	-	5	CASP3, UBC, RPS6KB1, HSPA8, PPP2R5D
EIF4G1	SNCA	No	-	3	UBC, HSPA8, PPP2R5D
EIF4G1	ATXN2	No	-	7	PABPC1L, PABPC1, PABPC4L, PABPC3, PABPC4, UBC, PABPC5
EIF4G1	ATXN3	No	-	3	UBC, RPS27A, UBB
GLUD2	MAPT	No	-	1	UBC
GLUD2	SNCA	No	-	1	UBC
GLUD2	ATXN2	No	-	1	UBC
GLUD2	ATXN3	No	-	1	UBC
MAPT	SNCA	Yes	binding	12	HSPA8, DYRK1A, PPP2R5D, HSPA4, PARK2, BDNF, AKT1, UBC, FYN, GSK3B, SYK, STUB1
MAPT	ATXN2	No	-	2	UBC, CDK5
MAPT	ATXN3	No	-	4	UBC, PARK2, GSK3B, STUB1
MAPT	FGF20	No	-	2	FGF2, YWHAZ
SNCA	ATXN2	No	-	1	UBC
SNCA	ATXN3	No	-	5	UBC, PARK2, GSK3B, STUB1, SUMO1
ATXN2	ATXN3	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
PINK1	PARK7	Yes	PPD complex	1	PARK2
PINK1	PARK2	Yes	PPD complex	1	PARK7
PINK1	SNCA	No	-	1	PARK7
PARK7	PARK2	Yes	PPD complex	1	PINK1
PARK7	SNCA	Yes	DJ-1-SNCA complex, high molecular weight complex	0
PARK2	SNCA	No	-	1	PARK7

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Parkinson's disease	hsa05012	5.59	8	LRRK2, PARK7, PARK2, HTRA2, SNCAIP, SNCA, UCHL1, PINK1
Metabolic pathways	hsa01100	2.49	5	GBA, PLA2G6, GLUD2, SYNJ1, ADH1C
Protein processing in endoplasmic reticulum	hsa04141	5.35	2	PARK2, ATXN3
Ras signaling pathway	hsa04014	4.9	2	PLA2G6, FGF20
Alzheimer's disease	hsa05010	5.34	2	MAPT, SNCA
MAPK signaling pathway	hsa04010	4.63	2	MAPT, FGF20

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Neurodegenerative diseases	NEW	4.27	0.0	EIF4G1, LRRK2, PARK7, TBP, MAPT, PARK2, HTRA2, SNCAIP, SNCA, ATXN3, UCHL1, PINK1
Parkinson's disease (hsa05012)	-	5.59	0.0	EIF4G1, LRRK2, PARK7, PARK2, HTRA2, SNCAIP, SNCA, UCHL1, PINK1

REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	5	GBA, PLA2G6, GLUD2, SYNJ1, ADH1C
Immune System	R-HSA-168256	2.37	4	PLA2G6, PARK2, EIF4G1, FGF20
Signal Transduction	R-HSA-162582	1.78	4	EIF4G1, FGF20, VPS35, ADH1C
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	GBA, PLA2G6, SYNJ1
Gene Expression	R-HSA-74160	2.72	3	TBP, NR4A2, EIF4G1
Disease	R-HSA-1643685	3.33	3	TBP, SNCA, FGF20
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	EIF4G1, FGF20
Innate Immune System	R-HSA-168249	3.17	2	PLA2G6, FGF20
Phospholipid metabolism	R-HSA-1483257	5.83	2	PLA2G6, SYNJ1
IRS-mediated signalling	R-HSA-112399	4.87	2	EIF4G1, FGF20
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	EIF4G1, FGF20
PI3K Cascade	R-HSA-109704	6.68	2	EIF4G1, FGF20
IGF1R signaling cascade	R-HSA-2428924	4.85	2	EIF4G1, FGF20
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	EIF4G1, FGF20
Signaling by Insulin receptor	R-HSA-74752	4.73	2	EIF4G1, FGF20
Adaptive Immune System	R-HSA-1280218	3.19	2	PARK2, FGF20
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	EIF4G1, FGF20

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	28	PLA2G6, TBP, EIF4G1, SNCAIP, ADH1C, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, SNCA, PODXL, PINK1, CHCHD2, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, GLUD2, ATXN2, PARK2, UCHL1
protein binding (GO:0005515)	0.46	25	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, FGF20, ATXN3, VPS35, ATXN2, PARK2, DNAJC6, UCHL1
catalytic activity (GO:0003824)	1.05	17	PLA2G6, GLUD2, LRRK2, ATP13A2, FBXO7, DNAJC6, PARK2, ADH1C, SYNJ1, HTRA2, FGF20, GBA, SNCA, UCHL1, ATXN3, PARK7, PINK1
organic cyclic compound binding (GO:0097159)	1.05	15	CHCHD2, GLUD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, ATP13A2, GIGYF2, SYNJ1, ATXN3, PARK7, PINK1, SNCA
heterocyclic compound binding (GO:1901363)	1.06	15	CHCHD2, GLUD2, ATXN2, LRRK2, PARK7, TBP, NR4A2, PARK2, EIF4G1, ATP13A2, GIGYF2, SYNJ1, ATXN3, SNCA, PINK1
enzyme binding (GO:0019899)	2.27	12	PLA2G6, LRRK2, TBP, FBXO7, PARK7, PARK2, SNCAIP, SNCA, UCHL1, ATXN3, MAPT, PINK1
nucleic acid binding (GO:0003676)	1.44	11	CHCHD2, ATXN2, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SYNJ1, ATXN3, PARK7, SNCA
hydrolase activity (GO:0016787)	1.9	10	PLA2G6, LRRK2, ATP13A2, DNAJC6, HTRA2, GBA, SYNJ1, UCHL1, ATXN3, PARK7
ion binding (GO:0043167)	1.36	8	GLUD2, ATP13A2, NR4A2, PARK2, ADH1C, SNCA, PARK7, PINK1
cation binding (GO:0043169)	1.4	7	ATP13A2, NR4A2, PARK2, ADH1C, SNCA, PARK7, PINK1
receptor binding (GO:0005102)	2.43	7	ATXN2, PARK7, NR4A2, PARK2, FGF20, GBA, UCHL1
metal ion binding (GO:0046872)	1.41	7	ATP13A2, NR4A2, PARK2, ADH1C, SNCA, PARK7, PINK1
identical protein binding (GO:0042802)	2.63	7	LRRK2, NR4A2, PARK2, SNCAIP, SNCA, ATXN3, PARK7
DNA binding (GO:0003677)	1.92	7	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7
transcription regulatory region DNA binding (GO:0044212)	3.03	6	TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7
transition metal ion binding (GO:0046914)	2.48	6	ATP13A2, NR4A2, PARK2, ADH1C, SNCA, PARK7
regulatory region nucleic acid binding (GO:0001067)	3.03	6	TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7
kinase binding (GO:0019900)	3.32	6	PLA2G6, PARK2, PARK7, FBXO7, MAPT, PINK1
protein domain specific binding (GO:0019904)	3.32	6	DNAJC6, PARK2, SYNJ1, MAPT, PINK1, SNCA
regulatory region DNA binding (GO:0000975)	3.03	6	TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7
small molecule binding (GO:0036094)	1.89	5	ATP13A2, SYNJ1, GLUD2, LRRK2, PINK1
ubiquitin protein ligase binding (GO:0031625)	4.17	5	PARK2, UCHL1, ATXN3, SNCAIP, PINK1
ubiquitin-like protein ligase binding (GO:0044389)	4.15	5	PARK2, UCHL1, ATXN3, SNCAIP, PINK1
nucleotide binding (GO:0000166)	1.96	5	ATP13A2, SYNJ1, GLUD2, LRRK2, PINK1
protein kinase binding (GO:0019901)	3.44	5	PARK2, PLA2G6, FBXO7, MAPT, PINK1
transferase activity (GO:0016740)	1.95	5	FBXO7, LRRK2, PARK2, FGF20, PINK1
zinc ion binding (GO:0008270)	2.66	5	ATP13A2, NR4A2, PARK2, SNCA, ADH1C
molecular function regulator (GO:0098772)	2.51	5	PARK7, FGF20, LRRK2, PINK1, SNCA
nucleoside phosphate binding (GO:1901265)	1.96	5	ATP13A2, SYNJ1, GLUD2, LRRK2, PINK1
RNA binding (GO:0003723)	2.36	5	EIF4G1, GIGYF2, SYNJ1, ATXN2, PARK7
tubulin binding (GO:0015631)	4.1	4	SNCA, PARK2, MAPT, LRRK2
sequence-specific DNA binding (GO:0043565)	2.79	4	TBP, NR4A2, PARK2, CHCHD2
poly(A) RNA binding (GO:0044822)	2.69	4	PARK7, GIGYF2, EIF4G1, ATXN2
adenyl ribonucleotide binding (GO:0032559)	2.41	4	ATP13A2, GLUD2, LRRK2, PINK1
cytoskeletal protein binding (GO:0008092)	3.02	4	MAPT, PARK2, SNCA, LRRK2
carbohydrate derivative binding (GO:0097367)	2.03	4	ATP13A2, GLUD2, LRRK2, PINK1
enzyme regulator activity (GO:0030234)	2.85	4	PARK7, LRRK2, PINK1, SNCA
adenyl nucleotide binding (GO:0030554)	2.4	4	ATP13A2, GLUD2, LRRK2, PINK1
transcription factor binding (GO:0008134)	3.46	4	TBP, NR4A2, CHCHD2, PARK7
SH3 domain binding (GO:0017124)	4.98	4	DNAJC6, MAPT, PARK2, SYNJ1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	4	ATP13A2, GLUD2, LRRK2, PINK1
nucleoside binding (GO:0001882)	2.21	4	ATP13A2, GLUD2, LRRK2, PINK1
purine nucleoside binding (GO:0001883)	2.22	4	ATP13A2, GLUD2, LRRK2, PINK1
ribonucleoside binding (GO:0032549)	2.22	4	ATP13A2, GLUD2, LRRK2, PINK1
purine ribonucleotide binding (GO:0032555)	2.2	4	ATP13A2, GLUD2, LRRK2, PINK1
purine nucleotide binding (GO:0017076)	2.19	4	ATP13A2, GLUD2, LRRK2, PINK1
peptidase activity (GO:0008233)	3.23	4	PARK7, ATXN3, UCHL1, HTRA2
double-stranded DNA binding (GO:0003690)	3.09	4	TBP, NR4A2, PARK2, PARK7
purine ribonucleoside binding (GO:0032550)	2.22	4	ATP13A2, GLUD2, LRRK2, PINK1
ribonucleotide binding (GO:0032553)	2.19	4	ATP13A2, GLUD2, LRRK2, PINK1
oxidoreductase activity (GO:0016491)	3.12	4	PARK7, GLUD2, SNCA, ADH1C
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	3	TBP, NR4A2, ATXN3
macromolecular complex binding (GO:0044877)	2.61	3	SYNJ1, MAPT, LRRK2
enzyme activator activity (GO:0008047)	3.56	3	PARK7, LRRK2, PINK1
anion binding (GO:0043168)	4.17	3	ATP13A2, SNCA, GLUD2
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	3	TBP, NR4A2, PARK2
protease binding (GO:0002020)	5.08	3	PARK7, PARK2, PINK1
protein kinase activity (GO:0004672)	3.27	3	LRRK2, FGF20, PINK1
protein complex binding (GO:0032403)	3.09	3	SYNJ1, MAPT, LRRK2
copper ion binding (GO:0005507)	5.71	3	ATP13A2, PARK7, SNCA
ATP binding (GO:0005524)	2.43	3	ATP13A2, LRRK2, PINK1
protein homodimerization activity (GO:0042803)	3.16	3	NR4A2, PARK7, LRRK2
microtubule binding (GO:0008017)	4.42	3	MAPT, SNCA, LRRK2
kinase activity (GO:0016301)	2.93	3	FGF20, LRRK2, PINK1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	3	PLA2G6, DNAJC6, SYNJ1
core promoter binding (GO:0001047)	4.71	3	TBP, NR4A2, PARK7
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	FGF20, LRRK2, PINK1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	FGF20, LRRK2, PINK1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	TBP, NR4A2, PARK2
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	3	UCHL1, ATXN3, HTRA2
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	3	TBP, NR4A2, PARK2
protein dimerization activity (GO:0046983)	2.72	3	NR4A2, PARK7, LRRK2
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	TBP, NR4A2, PARK2
protein C-terminus binding (GO:0008022)	4.5	2	SYNJ1, ATXN2
endopeptidase activity (GO:0004175)	3.63	2	UCHL1, HTRA2
phosphatase activity (GO:0016791)	4.11	2	DNAJC6, SYNJ1
carboxylic acid binding (GO:0031406)	4.64	2	SNCA, GLUD2
ubiquitinyl hydrolase activity (GO:0101005)	5.07	2	UCHL1, ATXN3
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	DNAJC6, SYNJ1
exopeptidase activity (GO:0008238)	5.07	2	UCHL1, ATXN3
signal transducer activity (GO:0004871)	2.28	2	NR4A2, LRRK2
G-protein coupled receptor binding (GO:0001664)	4.18	2	UCHL1, PARK2
enzyme inhibitor activity (GO:0004857)	3.78	2	SNCA, LRRK2
cysteine-type peptidase activity (GO:0008234)	4.51	2	UCHL1, ATXN3
repressing transcription factor binding (GO:0070491)	5.71	2	TBP, PARK7
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	FBXO7, PARK2
ubiquitin-like protein-specific protease activity (GO:0019783)	4.97	2	UCHL1, ATXN3
guanyl nucleotide binding (GO:0019001)	3.73	2	GLUD2, LRRK2
ligase activity (GO:0016874)	3.72	2	UCHL1, PARK2
magnesium ion binding (GO:0000287)	4.41	2	SNCA, PINK1
structural molecule activity (GO:0005198)	3.1	2	MAPT, LRRK2
actin binding (GO:0003779)	3.74	2	PARK2, LRRK2
guanyl ribonucleotide binding (GO:0032561)	3.73	2	GLUD2, LRRK2
transporter activity (GO:0005215)	2.57	2	ATP13A2, VPS35
ubiquitin-specific protease binding (GO:1990381)	7.25	2	PARK7, PARK2
GTP binding (GO:0005525)	3.78	2	GLUD2, LRRK2
steroid hormone receptor binding (GO:0035258)	5.32	2	NR4A2, PARK7
cupric ion binding (GO:1903135)	9.05	2	ATP13A2, PARK7
omega peptidase activity (GO:0008242)	6.91	2	UCHL1, ATXN3
peptidase regulator activity (GO:0061134)	4.37	2	SNCA, PINK1
nuclear hormone receptor binding (GO:0035257)	4.7	2	NR4A2, PARK7
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	ATP13A2, LRRK2
beta-catenin binding (GO:0008013)	5.3	2	NR4A2, PARK2
phospholipase binding (GO:0043274)	6.91	2	SNCA, PARK2
ubiquitin-like protein conjugating enzyme binding (GO:0044390)	6.21	2	PARK7, PARK2
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	TBP, NR4A2
hormone receptor binding (GO:0051427)	4.57	2	NR4A2, PARK7
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	PARK2, FBXO7
thiol-dependent ubiquitinyl hydrolase activity (GO:0036459)	5.07	2	UCHL1, ATXN3
protein serine/threonine kinase activity (GO:0004674)	3.64	2	LRRK2, PINK1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	ATP13A2, LRRK2
substrate-specific transporter activity (GO:0022892)	2.72	2	ATP13A2, VPS35
growth factor receptor binding (GO:0070851)	4.87	2	FGF20, ATXN2
ubiquitin-like protein binding (GO:0032182)	4.93	2	UCHL1, PARK2
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	ATP13A2, LRRK2
pyrophosphatase activity (GO:0016462)	3.04	2	ATP13A2, LRRK2
thiol-dependent ubiquitin-specific protease activity (GO:0004843)	5.43	2	UCHL1, ATXN3
ubiquitin binding (GO:0043130)	5.09	2	UCHL1, PARK2
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	2	TBP, NR4A2
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)	5.77	2	TBP, NR4A2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein kinase binding (GO:0019901)	-	3.44	0.036	TBP, FBXO7, DNAJC6, PARK2, DNAJC13, SNCA, ATXN3, MAPT, PINK1
ubiquitin protein ligase binding (GO:0031625)	-	4.17	0.035	PARK2, SNCAIP, ATXN3, PINK1
small conjugating protein ligase binding (GO:0044389)	-	4.15	0.035	PARK2, SNCAIP, ATXN3, PINK1
protease binding (GO:0002020)	-	5.08	0.048	PARK7, PARK2, PINK1
ubiquitin-specific protease binding (GO:1990381)	-	7.25	0.003	PARK7, PARK2
small protein conjugating enzyme binding (GO:0044390)	-	6.21	0.035	PARK7, PARK2
hydrolase activity, acting on ester bonds (GO:0016788)	-	3.1	0.03	VPS35, PLA2G6, TBP, MAPT, PARK2, EIF4G1, DNAJC6, SYNJ1, UCHL1, ATXN3, SNCA
enzyme binding (GO:0019899)	-	2.27	0.0	VPS35, ATXN2, LRRK2, TBP, PARK2, PODXL, MAPT, FBXO7, EIF4G1, HTRA2, DNAJC6, DNAJC13, SNCAIP, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
protein binding (GO:0005515)	-	0.46	0.027	PLA2G6, TBP, SNCAIP, GBA, UCHL1, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, FGF20, ATXN3, VPS35, ATXN2, PARK2, DNAJC6

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	27	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, DNAJC13, UCHL1, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, ATXN2, PARK2, VPS13C, DNAJC6, PARK7
biological regulation (GO:0065007)	0.39	27	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, DNAJC13, UCHL1, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, ATXN2, PARK2, VPS13C, DNAJC6, PARK7
regulation of biological process (GO:0050789)	0.45	27	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, ATXN2, PARK2, VPS13C, UCHL1
single-organism process (GO:0044699)	0.48	27	PLA2G6, TBP, SNCAIP, ADH1C, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, GLUD2, PARK2, VPS13C, UCHL1
regulation of cellular process (GO:0050794)	0.5	27	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, ATXN2, PARK2, VPS13C, UCHL1
organic substance metabolic process (GO:0071704)	0.63	24	PLA2G6, TBP, CHCHD2, SNCAIP, ADH1C, GBA, SYNJ1, PARK7, HTRA2, SNCA, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, ATXN2, PARK2, DNAJC6, UCHL1
metabolic process (GO:0008152)	0.58	24	PLA2G6, TBP, CHCHD2, SNCAIP, ADH1C, GBA, SYNJ1, PARK7, HTRA2, SNCA, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, ATXN2, PARK2, DNAJC6, UCHL1
primary metabolic process (GO:0044238)	0.69	23	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, UCHL1, PARK7, HTRA2, SNCA, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, ATXN2, PARK2, DNAJC6
single-organism cellular process (GO:0044763)	0.65	23	PLA2G6, SNCAIP, GBA, SYNJ1, UCHL1, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, PARK2, VPS13C, DNAJC6
cellular metabolic process (GO:0044237)	0.69	23	PLA2G6, TBP, CHCHD2, SNCAIP, GBA, SYNJ1, PARK7, HTRA2, SNCA, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, GLUD2, ATXN2, PARK2, DNAJC6, UCHL1
regulation of primary metabolic process (GO:0080090)	1.08	19	CHCHD2, ATXN2, LRRK2, PARK7, ATP13A2, PARK2, NR4A2, FBXO7, EIF4G1, HTRA2, TBP, GIGYF2, FGF20, PLA2G6, GBA, SNCA, ATXN3, UCHL1, PINK1
regulation of metabolic process (GO:0019222)	1.02	19	CHCHD2, ATXN2, LRRK2, PARK7, ATP13A2, PARK2, NR4A2, FBXO7, EIF4G1, HTRA2, TBP, GIGYF2, FGF20, PLA2G6, GBA, SNCA, ATXN3, UCHL1, PINK1
regulation of macromolecule metabolic process (GO:0060255)	1.08	19	CHCHD2, ATXN2, LRRK2, PARK7, TBP, PARK2, NR4A2, FBXO7, EIF4G1, HTRA2, ATP13A2, GIGYF2, FGF20, PLA2G6, GBA, SNCA, ATXN3, UCHL1, PINK1
cellular macromolecule metabolic process (GO:0044260)	0.93	19	EIF4G1, CHCHD2, ATXN2, LRRK2, ATP13A2, PARK2, PARK7, FBXO7, GIGYF2, HTRA2, DNAJC6, TBP, SNCAIP, FGF20, SNCA, UCHL1, ATXN3, NR4A2, PINK1
regulation of cellular metabolic process (GO:0031323)	1.07	19	ATXN2, CHCHD2, LRRK2, PLA2G6, ATP13A2, PARK2, NR4A2, FBXO7, EIF4G1, HTRA2, TBP, GIGYF2, FGF20, GBA, SNCA, UCHL1, ATXN3, PARK7, PINK1
macromolecule metabolic process (GO:0043170)	0.83	19	CHCHD2, ATXN2, LRRK2, TBP, PARK2, NR4A2, FBXO7, EIF4G1, HTRA2, DNAJC6, ATP13A2, GIGYF2, FGF20, SNCAIP, UCHL1, ATXN3, PARK7, PINK1, SNCA
positive regulation of biological process (GO:0048518)	1.2	19	EIF4G1, VPS35, LRRK2, PLA2G6, PARK7, TBP, NR4A2, MAPT, PARK2, CHCHD2, HTRA2, ATP13A2, FGF20, GBA, SYNJ1, ATXN3, PODXL, PINK1, SNCA
positive regulation of cellular process (GO:0048522)	1.3	19	EIF4G1, VPS35, LRRK2, PLA2G6, PARK7, TBP, NR4A2, MAPT, PARK2, CHCHD2, HTRA2, ATP13A2, FGF20, GBA, SYNJ1, ATXN3, PODXL, PINK1, SNCA
negative regulation of biological process (GO:0048519)	1.33	18	PLA2G6, ATXN2, LRRK2, PODXL, ATP13A2, PARK2, NR4A2, MAPT, FBXO7, VPS35, HTRA2, GIGYF2, VPS13C, GBA, SNCA, UCHL1, PARK7, PINK1
cellular component organization (GO:0016043)	1.24	17	LRRK2, ATXN2, PARK7, ATP13A2, PARK2, NR4A2, MAPT, FBXO7, VPS13C, HTRA2, DNAJC13, SYNJ1, SNCA, UCHL1, ATXN3, DNAJC6, PINK1
cellular component organization or biogenesis (GO:0071840)	1.22	17	LRRK2, ATXN2, ATP13A2, FBXO7, NR4A2, MAPT, PARK2, VPS13C, HTRA2, DNAJC6, DNAJC13, SYNJ1, SNCA, UCHL1, ATXN3, PARK7, PINK1
regulation of response to stimulus (GO:0048583)	1.54	16	CHCHD2, LRRK2, TBP, NR4A2, PARK2, VPS35, HTRA2, VPS13C, FGF20, PLA2G6, GBA, SNCA, UCHL1, ATXN3, PARK7, PINK1
response to stimulus (GO:0050896)	1.22	16	EIF4G1, LRRK2, ATP13A2, NR4A2, MAPT, PARK2, PLA2G6, HTRA2, GIGYF2, GBA, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
regulation of localization (GO:0032879)	1.94	16	VPS35, ATXN2, LRRK2, PARK7, ATP13A2, PODXL, MAPT, PARK2, PLA2G6, HTRA2, DNAJC13, SNCAIP, SYNJ1, DNAJC6, PINK1, SNCA
regulation of protein metabolic process (GO:0051246)	1.93	16	EIF4G1, LRRK2, ATXN2, ATP13A2, FBXO7, UCHL1, PARK2, PLA2G6, HTRA2, GIGYF2, FGF20, GBA, SNCA, ATXN3, PARK7, PINK1
negative regulation of cellular process (GO:0048523)	1.41	16	PLA2G6, ATXN2, LRRK2, PODXL, ATP13A2, PARK2, NR4A2, FBXO7, VPS13C, HTRA2, GIGYF2, GBA, SNCA, UCHL1, PARK7, PINK1
cellular protein metabolic process (GO:0044267)	1.63	15	EIF4G1, LRRK2, PARK7, ATP13A2, PARK2, DNAJC6, FBXO7, SNCAIP, HTRA2, GIGYF2, FGF20, SNCA, ATXN3, UCHL1, PINK1
regulation of cellular protein metabolic process (GO:0032268)	1.99	15	PLA2G6, LRRK2, ATXN2, ATP13A2, FBXO7, PARK7, PARK2, EIF4G1, HTRA2, GIGYF2, FGF20, GBA, SNCA, UCHL1, PINK1
protein metabolic process (GO:0019538)	1.45	15	EIF4G1, LRRK2, ATP13A2, PARK2, DNAJC6, FBXO7, SNCAIP, HTRA2, GIGYF2, FGF20, SNCA, UCHL1, ATXN3, PARK7, PINK1
regulation of transport (GO:0051049)	2.24	15	VPS35, ATXN2, LRRK2, PARK7, ATP13A2, DNAJC6, PARK2, PLA2G6, HTRA2, DNAJC13, SNCAIP, SYNJ1, MAPT, PINK1, SNCA
regulation of cellular component organization (GO:0051128)	2.01	15	PLA2G6, ATXN2, LRRK2, PARK7, ATP13A2, PODXL, MAPT, PARK2, VPS13C, HTRA2, SNCAIP, SYNJ1, DNAJC6, PINK1, SNCA
localization (GO:0051179)	1.4	15	VPS35, ATXN2, LRRK2, ATP13A2, FBXO7, UCHL1, MAPT, PARK2, VPS13C, DNAJC13, SYNJ1, SNCA, ATXN3, PARK7, PINK1
regulation of biological quality (GO:0065008)	1.68	14	EIF4G1, VPS35, LRRK2, ATP13A2, PARK2, PARK7, FBXO7, SNCAIP, GIGYF2, VPS13C, PLA2G6, GBA, SNCA, PINK1
establishment of localization (GO:0051234)	1.48	14	VPS35, LRRK2, ATXN2, ATP13A2, PARK2, PARK7, FBXO7, DNAJC13, VPS13C, SYNJ1, UCHL1, MAPT, PINK1, SNCA
response to stress (GO:0006950)	1.8	14	EIF4G1, LRRK2, ATP13A2, NR4A2, PARK2, PLA2G6, HTRA2, GIGYF2, GBA, SNCA, UCHL1, ATXN3, PARK7, PINK1
nitrogen compound metabolic process (GO:0006807)	1.13	14	CHCHD2, GLUD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, HTRA2, SNCAIP, PLA2G6, GBA, SNCA, ATXN3
regulation of signaling (GO:0023051)	1.72	14	VPS35, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, SNCAIP, FGF20, GBA, SNCA, UCHL1, PARK7, PINK1
regulation of cell communication (GO:0010646)	1.73	14	VPS35, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, SNCAIP, FGF20, GBA, SNCA, UCHL1, PARK7, PINK1
organelle organization (GO:0006996)	2.02	13	ATXN2, LRRK2, ATP13A2, FBXO7, PARK7, PARK2, HTRA2, DNAJC13, VPS13C, SNCA, ATXN3, MAPT, PINK1
organic substance biosynthetic process (GO:1901576)	1.34	13	CHCHD2, GLUD2, PLA2G6, TBP, NR4A2, PARK2, EIF4G1, FGF20, GBA, SYNJ1, ATXN3, PARK7, SNCA
multicellular organismal process (GO:0032501)	1.45	13	EIF4G1, LRRK2, PARK7, NR4A2, PARK2, PLA2G6, HTRA2, GIGYF2, GBA, SYNJ1, UCHL1, MAPT, SNCA
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	13	CHCHD2, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, FGF20, GBA, SNCA, ATXN3, PARK7, PINK1
single-multicellular organism process (GO:0044707)	1.78	13	EIF4G1, LRRK2, PARK7, NR4A2, PARK2, PLA2G6, HTRA2, GIGYF2, GBA, SYNJ1, UCHL1, MAPT, SNCA
regulation of signal transduction (GO:0009966)	1.84	13	VPS35, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, FGF20, GBA, SNCA, UCHL1, PARK7, PINK1
single-organism behavior (GO:0044708)	3.79	13	EIF4G1, LRRK2, NR4A2, MAPT, PARK2, PLA2G6, HTRA2, GIGYF2, SYNJ1, UCHL1, ATXN3, PARK7, SNCA
transport (GO:0006810)	1.51	13	VPS35, ATXN2, LRRK2, ATP13A2, FBXO7, UCHL1, MAPT, PARK2, VPS13C, DNAJC13, SYNJ1, SNCA, PARK7
behavior (GO:0007610)	3.47	13	EIF4G1, LRRK2, PARK7, NR4A2, PARK2, PLA2G6, HTRA2, GIGYF2, SYNJ1, UCHL1, ATXN3, MAPT, SNCA
cellular biosynthetic process (GO:0044249)	1.37	13	CHCHD2, GLUD2, PLA2G6, TBP, NR4A2, PARK2, EIF4G1, FGF20, GBA, SYNJ1, ATXN3, PARK7, SNCA
biosynthetic process (GO:0009058)	1.32	13	EIF4G1, CHCHD2, GLUD2, TBP, NR4A2, PARK2, PLA2G6, FGF20, GBA, SYNJ1, ATXN3, PARK7, SNCA
regulation of molecular function (GO:0065009)	1.78	13	PLA2G6, LRRK2, ATP13A2, PARK2, NR4A2, FBXO7, HTRA2, FGF20, GBA, SNCA, UCHL1, PARK7, PINK1
positive regulation of metabolic process (GO:0009893)	1.74	13	CHCHD2, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, FGF20, GBA, SNCA, ATXN3, PARK7, PINK1
developmental process (GO:0032502)	1.36	12	LRRK2, NR4A2, MAPT, PARK2, HTRA2, GIGYF2, GBA, SYNJ1, UCHL1, ATXN3, PODXL, SNCA
single-organism metabolic process (GO:0044710)	1.63	12	PLA2G6, GLUD2, LRRK2, PARK7, PARK2, HTRA2, ADH1C, FGF20, GBA, SYNJ1, SNCA, PINK1
cellular response to stimulus (GO:0051716)	1.97	12	PLA2G6, LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, GIGYF2, GBA, SNCA, ATXN3, PARK7, PINK1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	12	ATXN2, LRRK2, PARK7, ATP13A2, PARK2, UCHL1, FBXO7, GIGYF2, GBA, SNCA, NR4A2, PINK1
cellular response to stress (GO:0033554)	2.51	12	PLA2G6, LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, GIGYF2, GBA, SNCA, ATXN3, PARK7, PINK1
regulation of organelle organization (GO:0033043)	2.72	12	PLA2G6, ATXN2, LRRK2, ATP13A2, PARK7, PARK2, HTRA2, VPS13C, SYNJ1, MAPT, PINK1, SNCA
catabolic process (GO:0009056)	2.38	12	EIF4G1, GLUD2, FBXO7, PARK7, PARK2, PLA2G6, HTRA2, GBA, SYNJ1, ATXN3, UCHL1, PINK1
positive regulation of cellular metabolic process (GO:0031325)	1.81	12	CHCHD2, LRRK2, TBP, NR4A2, PARK2, PLA2G6, HTRA2, FGF20, GBA, SNCA, PARK7, PINK1
regulation of catalytic activity (GO:0050790)	1.97	12	LRRK2, ATP13A2, FBXO7, NR4A2, PARK2, HTRA2, FGF20, GBA, SNCA, UCHL1, PARK7, PINK1
regulation of biosynthetic process (GO:0009889)	1.37	12	CHCHD2, ATXN2, PLA2G6, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SNCA, ATXN3, PARK7, PINK1
organic substance catabolic process (GO:1901575)	2.45	12	EIF4G1, GLUD2, FBXO7, UCHL1, PARK2, PLA2G6, HTRA2, GBA, SYNJ1, ATXN3, PARK7, PINK1
response to chemical (GO:0042221)	1.98	12	LRRK2, ATP13A2, NR4A2, MAPT, PARK2, HTRA2, GBA, SYNJ1, ATXN3, PARK7, PINK1, SNCA
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	12	CHCHD2, ATXN2, PLA2G6, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SNCA, ATXN3, PARK7, PINK1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	12	EIF4G1, CHCHD2, ATXN2, TBP, NR4A2, PARK2, PLA2G6, GIGYF2, SNCA, ATXN3, PARK7, PINK1
regulation of multicellular organismal process (GO:0051239)	1.87	12	EIF4G1, LRRK2, PARK7, FBXO7, NR4A2, PARK2, PLA2G6, HTRA2, FGF20, GBA, SYNJ1, MAPT
regulation of cellular biosynthetic process (GO:0031326)	1.38	12	CHCHD2, ATXN2, PLA2G6, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SNCA, ATXN3, PARK7, PINK1
negative regulation of metabolic process (GO:0009892)	1.93	12	LRRK2, ATXN2, ATP13A2, PARK2, NR4A2, FBXO7, GIGYF2, GBA, SNCA, UCHL1, PARK7, PINK1
negative regulation of cellular metabolic process (GO:0031324)	2.01	12	ATXN2, LRRK2, PARK7, ATP13A2, PARK2, UCHL1, FBXO7, GIGYF2, GBA, SNCA, NR4A2, PINK1
regulation of autophagy (GO:0010506)	4.21	12	VPS35, LRRK2, ATP13A2, PARK7, PARK2, HTRA2, VPS13C, GBA, SNCA, UCHL1, MAPT, PINK1
regulation of gene expression (GO:0010468)	1.37	12	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SNCA, ATXN3, PARK7, PINK1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	11	CHCHD2, ATXN2, TBP, NR4A2, PARK2, EIF4G1, GIGYF2, SNCA, ATXN3, PARK7, PINK1
regulation of cellular localization (GO:0060341)	3.03	11	PLA2G6, LRRK2, ATP13A2, PARK7, PARK2, HTRA2, DNAJC13, SNCAIP, SNCA, MAPT, PINK1
organic cyclic compound metabolic process (GO:1901360)	1.26	11	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, HTRA2, SNCAIP, SNCA, ATXN3
regulation of phosphate metabolic process (GO:0019220)	2.35	10	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
negative regulation of response to stimulus (GO:0048585)	2.52	10	LRRK2, NR4A2, PARK2, HTRA2, VPS13C, GBA, SNCA, UCHL1, PARK7, PINK1
positive regulation of response to stimulus (GO:0048584)	2.18	10	VPS35, LRRK2, PARK7, PARK2, PLA2G6, HTRA2, FGF20, SNCA, ATXN3, PINK1
cellular catabolic process (GO:0044248)	2.62	10	EIF4G1, GLUD2, FBXO7, PARK7, PARK2, HTRA2, GBA, ATXN3, UCHL1, PINK1
negative regulation of signaling (GO:0023057)	2.65	10	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, GBA, SNCA, UCHL1, PARK7, PINK1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	10	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, HTRA2, GBA, ATXN3
signal transduction (GO:0007165)	1.28	10	PLA2G6, LRRK2, NR4A2, MAPT, VPS35, HTRA2, GIGYF2, FGF20, PARK7, PINK1
cellular response to chemical stimulus (GO:0070887)	2.57	10	LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, GBA, SNCA, ATXN3, PARK7, PINK1
negative regulation of protein metabolic process (GO:0051248)	2.82	10	LRRK2, ATP13A2, PARK2, PARK7, FBXO7, GIGYF2, GBA, SNCA, UCHL1, PINK1
positive regulation of protein metabolic process (GO:0051247)	2.43	10	PLA2G6, LRRK2, PARK7, PARK2, HTRA2, FGF20, GBA, SNCA, ATXN3, PINK1
regulation of protein modification process (GO:0031399)	2.32	10	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
cellular aromatic compound metabolic process (GO:0006725)	1.3	10	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, SNCAIP, SNCA, ATXN3
cellular protein modification process (GO:0006464)	1.79	10	LRRK2, PARK7, ATP13A2, PARK2, DNAJC6, FBXO7, FGF20, ATXN3, UCHL1, PINK1
regulation of vesicle-mediated transport (GO:0060627)	3.63	10	PLA2G6, ATXN2, LRRK2, ATP13A2, DNAJC6, PARK2, DNAJC13, SYNJ1, SNCA, PINK1
regulation of phosphorus metabolic process (GO:0051174)	2.35	10	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
macromolecule modification (GO:0043412)	1.73	10	LRRK2, ATP13A2, PARK2, DNAJC6, FBXO7, FGF20, UCHL1, ATXN3, PARK7, PINK1
protein modification process (GO:0036211)	1.79	10	LRRK2, PARK7, ATP13A2, PARK2, DNAJC6, FBXO7, FGF20, ATXN3, UCHL1, PINK1
regulation of intracellular signal transduction (GO:1902531)	2.31	10	PLA2G6, LRRK2, TBP, PARK7, PARK2, HTRA2, FGF20, GBA, UCHL1, PINK1
response to organic substance (GO:0010033)	2.2	10	LRRK2, NR4A2, MAPT, PARK2, HTRA2, GBA, SYNJ1, ATXN3, PARK7, SNCA
single-organism localization (GO:1902578)	2.09	10	VPS35, ATP13A2, MAPT, PARK2, VPS13C, SYNJ1, UCHL1, PARK7, PINK1, SNCA
regulation of phosphorylation (GO:0042325)	2.5	10	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
single-organism developmental process (GO:0044767)	1.49	10	LRRK2, PODXL, MAPT, HTRA2, GIGYF2, GBA, SYNJ1, UCHL1, NR4A2, SNCA
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	10	LRRK2, ATP13A2, PARK2, PARK7, FBXO7, GIGYF2, GBA, SNCA, UCHL1, PINK1
regulation of cellular component biogenesis (GO:0044087)	3.08	10	PLA2G6, ATXN2, LRRK2, PODXL, MAPT, PARK2, SNCAIP, SNCA, PARK7, PINK1
regulation of protein phosphorylation (GO:0001932)	2.57	10	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
negative regulation of cell communication (GO:0010648)	2.66	10	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, GBA, SNCA, UCHL1, PARK7, PINK1
locomotory behavior (GO:0007626)	4.53	9	LRRK2, PARK7, MAPT, PARK2, HTRA2, GIGYF2, SNCA, UCHL1, NR4A2
organonitrogen compound metabolic process (GO:1901564)	2.32	9	EIF4G1, GLUD2, LRRK2, NR4A2, PARK2, HTRA2, SNCAIP, GBA, SNCA
negative regulation of signal transduction (GO:0009968)	2.75	9	LRRK2, NR4A2, PARK2, HTRA2, GBA, SNCA, UCHL1, PARK7, PINK1
positive regulation of transport (GO:0051050)	2.9	9	VPS35, ATP13A2, PARK7, PARK2, PLA2G6, HTRA2, SYNJ1, SNCA, PINK1
regulation of developmental process (GO:0050793)	2.1	9	EIF4G1, LRRK2, FBXO7, MAPT, PARK2, HTRA2, FGF20, SYNJ1, PINK1
cellular developmental process (GO:0048869)	1.82	9	LRRK2, DNAJC13, MAPT, HTRA2, GIGYF2, FGF20, NR4A2, UCHL1, PODXL
regulation of response to stress (GO:0080134)	2.53	9	CHCHD2, LRRK2, PARK7, PARK2, HTRA2, VPS13C, GBA, ATXN3, PINK1
anatomical structure development (GO:0048856)	1.58	9	LRRK2, PODXL, NR4A2, PARK2, HTRA2, SYNJ1, UCHL1, ATXN3, MAPT
positive regulation of signaling (GO:0023056)	2.41	9	VPS35, LRRK2, PARK7, PARK2, PLA2G6, HTRA2, FGF20, SNCA, PINK1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	9	PLA2G6, LRRK2, PARK7, PARK2, HTRA2, FGF20, GBA, SNCA, PINK1
organic substance transport (GO:0071702)	2.15	9	VPS35, ATXN2, ATP13A2, FBXO7, PARK7, PARK2, DNAJC13, VPS13C, SNCA
cell communication (GO:0007154)	3.04	9	LRRK2, NR4A2, PARK2, FGF20, GBA, SNCA, UCHL1, ATXN3, PARK7
positive regulation of cell communication (GO:0010647)	2.41	9	VPS35, LRRK2, PARK7, PARK2, PLA2G6, HTRA2, FGF20, SNCA, PINK1
regulation of cell death (GO:0010941)	2.43	9	PLA2G6, LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
establishment of localization in cell (GO:0051649)	2.47	9	VPS35, FBXO7, MAPT, PARK2, VPS13C, SYNJ1, UCHL1, PARK7, SNCA
cellular localization (GO:0051641)	2.32	9	VPS35, LRRK2, FBXO7, MAPT, PARK2, VPS13C, SYNJ1, UCHL1, SNCA
regulation of catabolic process (GO:0009894)	3.52	8	LRRK2, ATP13A2, PARK7, PARK2, GBA, SNCA, ATXN3, PINK1
positive regulation of protein modification process (GO:0031401)	2.7	8	PLA2G6, LRRK2, PARK7, PARK2, FGF20, GBA, SNCA, PINK1
regulation of secretion (GO:0051046)	3.2	8	VPS35, LRRK2, ATP13A2, PARK2, PLA2G6, SNCAIP, SNCA, PINK1
positive regulation of biosynthetic process (GO:0009891)	2.29	8	CHCHD2, TBP, NR4A2, PARK2, PLA2G6, SNCA, PARK7, PINK1
regulation of intracellular transport (GO:0032386)	3.58	8	LRRK2, ATP13A2, PARK7, PARK2, HTRA2, DNAJC13, MAPT, PINK1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	8	CHCHD2, TBP, NR4A2, PARK2, PLA2G6, SNCA, PARK7, PINK1
regulation of secretion by cell (GO:1903530)	3.28	8	VPS35, LRRK2, ATP13A2, PARK2, PLA2G6, SNCAIP, SNCA, PINK1
regulation of protein transport (GO:0051223)	3.12	8	VPS35, LRRK2, ATP13A2, PARK7, PARK2, PLA2G6, HTRA2, PINK1
regulation of apoptotic process (GO:0042981)	2.5	8	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
mitochondrion organization (GO:0007005)	3.69	8	LRRK2, PARK2, PARK7, FBXO7, HTRA2, VPS13C, SNCA, PINK1
regulation of protein localization (GO:0032880)	2.88	8	VPS35, LRRK2, ATP13A2, PARK7, PARK2, PLA2G6, HTRA2, PINK1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	8	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
positive regulation of signal transduction (GO:0009967)	2.5	8	VPS35, LRRK2, PARK7, PARK2, PLA2G6, HTRA2, FGF20, PINK1
regulation of kinase activity (GO:0043549)	3.07	8	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
cellular response to organic substance (GO:0071310)	2.78	8	LRRK2, NR4A2, PARK2, HTRA2, GBA, SNCA, ATXN3, PARK7
adult locomotory behavior (GO:0008344)	5.3	8	PARK7, MAPT, PARK2, HTRA2, GIGYF2, SNCA, UCHL1, NR4A2
regulation of programmed cell death (GO:0043067)	2.49	8	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
positive regulation of molecular function (GO:0044093)	2.23	8	LRRK2, NR4A2, PARK2, HTRA2, FGF20, SNCA, PARK7, PINK1
positive regulation of cellular component organization (GO:0051130)	2.68	8	PLA2G6, PARK7, PARK2, HTRA2, SYNJ1, MAPT, PINK1, SNCA
regulation of establishment of protein localization (GO:0070201)	3.02	8	VPS35, LRRK2, ATP13A2, PARK7, PARK2, PLA2G6, HTRA2, PINK1
negative regulation of phosphate metabolic process (GO:0045936)	3.45	8	LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	8	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7, PINK1
negative regulation of cell death (GO:0060548)	2.95	8	LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	8	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7, PINK1
single-organism transport (GO:0044765)	2.18	8	VPS35, ATP13A2, MAPT, PARK2, SYNJ1, UCHL1, PARK7, SNCA
regulation of proteolysis (GO:0030162)	3.2	8	LRRK2, ATP13A2, PARK7, PARK2, HTRA2, GBA, SNCA, PINK1
regulation of RNA biosynthetic process (GO:2001141)	1.55	8	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7, PINK1
regulation of neuron death (GO:1901214)	4.19	8	LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
negative regulation of neuron death (GO:1901215)	4.57	8	LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
response to oxidative stress (GO:0006979)	3.9	8	LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
heterocycle metabolic process (GO:0046483)	1.31	8	CHCHD2, ATXN2, LRRK2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
response to oxygen-containing compound (GO:1901700)	2.57	8	LRRK2, NR4A2, PARK2, HTRA2, GBA, SYNJ1, PARK7, SNCA
adult behavior (GO:0030534)	4.79	8	PARK7, MAPT, PARK2, HTRA2, GIGYF2, SNCA, UCHL1, NR4A2
negative regulation of phosphorylation (GO:0042326)	3.7	8	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	8	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
negative regulation of protein modification process (GO:0031400)	3.4	8	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
regulation of cellular response to stress (GO:0080135)	3.4	8	CHCHD2, LRRK2, PARK7, PARK2, HTRA2, VPS13C, ATXN3, PINK1
regulation of transferase activity (GO:0051338)	2.88	8	LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of transcription, DNA-templated (GO:0006355)	1.56	8	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7, PINK1
phosphate-containing compound metabolic process (GO:0006796)	2.16	8	PLA2G6, LRRK2, ATP13A2, DNAJC6, FGF20, SYNJ1, SNCA, PINK1
phosphorus metabolic process (GO:0006793)	2.15	8	PLA2G6, LRRK2, ATP13A2, DNAJC6, FGF20, SYNJ1, SNCA, PINK1
regulation of mitochondrion organization (GO:0010821)	4.34	8	PLA2G6, LRRK2, ATP13A2, PARK7, PARK2, HTRA2, VPS13C, PINK1
negative regulation of protein phosphorylation (GO:0001933)	3.79	8	LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of RNA metabolic process (GO:0051252)	1.52	8	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3, PARK7, PINK1
protein localization (GO:0008104)	2.36	7	VPS35, LRRK2, DNAJC13, PARK2, FBXO7, VPS13C, ATXN3
regulation of cellular catabolic process (GO:0031329)	3.83	7	LRRK2, ATP13A2, PARK7, PARK2, GBA, SNCA, PINK1
regulation of apoptotic signaling pathway (GO:2001233)	3.83	7	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, PARK7, PINK1
negative regulation of cellular component organization (GO:0051129)	3.35	7	LRRK2, ATXN2, PARK7, PARK2, VPS13C, SNCA, PINK1
homeostatic process (GO:0042592)	2.61	7	PLA2G6, LRRK2, ATP13A2, PARK2, GIGYF2, GBA, SNCA
negative regulation of gene expression (GO:0010629)	2.48	7	LRRK2, NR4A2, PARK2, GIGYF2, SNCA, PARK7, PINK1
small molecule metabolic process (GO:0044281)	2.38	7	GLUD2, LRRK2, PARK7, ADH1C, GBA, SNCA, SYNJ1
positive regulation of cell death (GO:0010942)	3.32	7	PLA2G6, LRRK2, PARK7, PARK2, HTRA2, SNCA, PINK1
negative regulation of catalytic activity (GO:0043086)	3.0	7	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1
positive regulation of catalytic activity (GO:0043085)	2.4	7	LRRK2, NR4A2, HTRA2, FGF20, SNCA, PARK7, PINK1
cellular macromolecule catabolic process (GO:0044265)	3.19	7	EIF4G1, PARK2, UCHL1, FBXO7, HTRA2, ATXN3, PINK1
negative regulation of transport (GO:0051051)	3.6	7	VPS35, ATXN2, LRRK2, MAPT, PARK2, SNCA, PARK7
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	7	PLA2G6, LRRK2, PARK7, FGF20, GBA, SNCA, PINK1
negative regulation of apoptotic process (GO:0043066)	3.04	7	LRRK2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
negative regulation of molecular function (GO:0044092)	2.74	7	LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1
proteolysis (GO:0006508)	2.73	7	PARK2, PARK7, FBXO7, HTRA2, ATXN3, UCHL1, PINK1
macromolecule localization (GO:0033036)	2.34	7	VPS35, LRRK2, DNAJC13, PARK2, FBXO7, VPS13C, ATXN3
negative regulation of programmed cell death (GO:0043069)	3.02	7	LRRK2, NR4A2, PARK2, HTRA2, SNCA, PARK7, PINK1
positive regulation of programmed cell death (GO:0043068)	3.38	7	PLA2G6, LRRK2, PARK7, PARK2, HTRA2, SNCA, PINK1
regulation of macroautophagy (GO:0016241)	4.98	7	VPS35, LRRK2, ATP13A2, UCHL1, VPS13C, GBA, PINK1
regulation of hydrolase activity (GO:0051336)	2.53	7	LRRK2, ATP13A2, PARK7, HTRA2, FGF20, SNCA, PINK1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	7	PLA2G6, LRRK2, PARK7, FGF20, GBA, SNCA, PINK1
regulation of protein kinase activity (GO:0045859)	3.15	7	LRRK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	7	CHCHD2, TBP, NR4A2, PARK2, PLA2G6, PARK7, PINK1
negative regulation of intracellular signal transduction (GO:1902532)	3.63	7	LRRK2, PARK7, PARK2, HTRA2, GBA, UCHL1, PINK1
cellular response to oxidative stress (GO:0034599)	4.7	7	LRRK2, ATP13A2, NR4A2, HTRA2, SNCA, PARK7, PINK1
macromolecule catabolic process (GO:0009057)	3.0	7	EIF4G1, PARK2, UCHL1, FBXO7, HTRA2, ATXN3, PINK1
RNA metabolic process (GO:0016070)	1.59	7	CHCHD2, ATXN2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
nucleic acid metabolic process (GO:0090304)	1.46	7	CHCHD2, ATXN2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	7	CHCHD2, TBP, NR4A2, PARK2, EIF4G1, GBA, ATXN3
response to external stimulus (GO:0009605)	2.55	7	PLA2G6, LRRK2, NR4A2, PARK2, GBA, SNCA, MAPT
positive regulation of organelle organization (GO:0010638)	3.38	7	PLA2G6, PARK7, PARK2, HTRA2, SYNJ1, MAPT, PINK1
regulation of protein catabolic process (GO:0042176)	3.83	7	LRRK2, ATP13A2, PARK7, PARK2, GBA, ATXN3, PINK1
regulation of multicellular organismal development (GO:2000026)	2.31	7	EIF4G1, LRRK2, PARK2, MAPT, FBXO7, FGF20, SYNJ1
organic hydroxy compound metabolic process (GO:1901615)	3.84	7	NR4A2, PARK2, ADH1C, SNCAIP, GBA, SNCA, SYNJ1
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	6	LRRK2, NR4A2, PARK2, HTRA2, PARK7, PINK1
regulation of intracellular protein transport (GO:0033157)	3.8	6	LRRK2, ATP13A2, PARK7, PARK2, HTRA2, PINK1
cellular macromolecule biosynthetic process (GO:0034645)	1.66	6	CHCHD2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
macromolecular complex subunit organization (GO:0043933)	2.14	6	LRRK2, ATXN2, DNAJC6, PARK2, SYNJ1, ATXN3
cell differentiation (GO:0030154)	2.14	6	LRRK2, DNAJC13, MAPT, GIGYF2, FGF20, NR4A2
modulation of synaptic transmission (GO:0050804)	4.09	6	PLA2G6, LRRK2, PARK2, SNCAIP, SNCA, PINK1
regulation of cellular protein localization (GO:1903827)	3.43	6	LRRK2, ATP13A2, PARK7, PARK2, HTRA2, PINK1
positive regulation of gene expression (GO:0010628)	2.35	6	CHCHD2, TBP, NR4A2, PARK2, PARK7, PINK1
cell surface receptor signaling pathway (GO:0007166)	2.09	6	VPS35, LRRK2, NR4A2, PLA2G6, GIGYF2, FGF20
intracellular signal transduction (GO:0035556)	2.39	6	LRRK2, PARK7, HTRA2, FGF20, MAPT, PINK1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	6	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3
regulation of MAPK cascade (GO:0043408)	3.22	6	LRRK2, UCHL1, PARK2, FGF20, GBA, PINK1
single-organism catabolic process (GO:0044712)	3.21	6	PLA2G6, GLUD2, PARK7, PARK2, GBA, SYNJ1
single-organism biosynthetic process (GO:0044711)	2.8	6	PLA2G6, GLUD2, PARK7, FGF20, GBA, SYNJ1
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	EIF4G1, PARK7, PARK2, PLA2G6, SYNJ1, MAPT
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	6	CHCHD2, TBP, NR4A2, PARK2, PARK7, PINK1
positive regulation of apoptotic process (GO:0043065)	3.38	6	PLA2G6, PARK7, PARK2, HTRA2, SNCA, PINK1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	6	CHCHD2, TBP, NR4A2, PARK2, PARK7, PINK1
lipid metabolic process (GO:0006629)	2.68	6	PLA2G6, HTRA2, FGF20, GBA, SYNJ1, SNCA
regulation of cellular protein catabolic process (GO:1903362)	4.23	6	LRRK2, ATP13A2, PARK7, PARK2, GBA, PINK1
regulation of cell differentiation (GO:0045595)	2.42	6	EIF4G1, LRRK2, PARK2, MAPT, FBXO7, SYNJ1
macromolecule biosynthetic process (GO:0009059)	1.61	6	CHCHD2, TBP, NR4A2, PARK2, EIF4G1, ATXN3
aromatic compound biosynthetic process (GO:0019438)	1.7	6	CHCHD2, TBP, NR4A2, PARK2, SNCA, ATXN3
positive regulation of intracellular signal transduction (GO:1902533)	2.95	6	PLA2G6, LRRK2, PARK7, PARK2, FGF20, PINK1
cellular lipid metabolic process (GO:0044255)	2.92	6	PLA2G6, HTRA2, FGF20, GBA, SYNJ1, SNCA
cellular response to oxygen-containing compound (GO:1901701)	3.22	6	LRRK2, NR4A2, PARK2, HTRA2, SNCA, PARK7
positive regulation of phosphorylation (GO:0042327)	2.9	6	PLA2G6, LRRK2, PARK7, FGF20, SNCA, PINK1
regulation of protein stability (GO:0031647)	4.33	6	VPS35, PARK2, PARK7, FBXO7, SNCA, PINK1
chemical homeostasis (GO:0048878)	2.97	6	PLA2G6, LRRK2, ATP13A2, PARK2, GBA, SNCA
single-organism organelle organization (GO:1902589)	2.68	6	PARK2, MAPT, FBXO7, SNCA, ATXN3, PINK1
positive regulation of proteolysis (GO:0045862)	3.86	6	LRRK2, PARK2, HTRA2, GBA, SNCA, PINK1
positive regulation of protein phosphorylation (GO:0001934)	2.95	6	PLA2G6, LRRK2, PARK7, FGF20, SNCA, PINK1
regulation of mitophagy (GO:1903146)	5.99	6	ATP13A2, PARK7, PARK2, HTRA2, VPS13C, PINK1
negative regulation of kinase activity (GO:0033673)	4.22	5	GBA, FBXO7, PARK7, PARK2, UCHL1
regulation of membrane potential (GO:0042391)	3.89	5	PARK7, PARK2, LRRK2, PINK1, SNCA
negative regulation of transferase activity (GO:0051348)	3.87	5	GBA, PARK2, PARK7, FBXO7, UCHL1
positive regulation of apoptotic signaling pathway (GO:2001235)	4.58	5	PLA2G6, PARK2, PARK7, PINK1, HTRA2
RNA biosynthetic process (GO:0032774)	1.84	5	TBP, PARK2, CHCHD2, ATXN3, NR4A2
positive regulation of secretion (GO:0051047)	3.85	5	ATP13A2, PLA2G6, VPS35, PINK1, SNCA
organonitrogen compound biosynthetic process (GO:1901566)	2.85	5	GBA, NR4A2, GLUD2, EIF4G1, SNCA
ion homeostasis (GO:0050801)	3.42	5	ATP13A2, PLA2G6, PARK2, SNCA, LRRK2
proteolysis involved in cellular protein catabolic process (GO:0051603)	3.59	5	PARK2, ATXN3, UCHL1, FBXO7, PINK1
movement of cell or subcellular component (GO:0006928)	2.61	5	MAPT, NR4A2, UCHL1, PODXL, LRRK2
cell-cell signaling (GO:0007267)	3.35	5	ATXN3, PARK7, PARK2, SNCA, FGF20
regulation of neuron apoptotic process (GO:0043523)	4.47	5	NR4A2, PARK2, PARK7, PINK1, SNCA
negative regulation of neuron apoptotic process (GO:0043524)	4.82	5	NR4A2, PARK2, PARK7, PINK1, SNCA
peptidyl-amino acid modification (GO:0018193)	2.98	5	ATP13A2, PARK7, FGF20, LRRK2, PINK1
positive regulation of secretion by cell (GO:1903532)	3.93	5	ATP13A2, PLA2G6, VPS35, PINK1, SNCA
inorganic ion homeostasis (GO:0098771)	3.43	5	ATP13A2, PLA2G6, PARK2, SNCA, LRRK2
positive regulation of protein transport (GO:0051222)	3.61	5	ATP13A2, PLA2G6, VPS35, PINK1, HTRA2
positive regulation of establishment of protein localization (GO:1904951)	3.49	5	ATP13A2, PLA2G6, VPS35, PINK1, HTRA2
modification-dependent macromolecule catabolic process (GO:0043632)	3.69	5	FBXO7, ATXN3, UCHL1, PARK2, PINK1
nucleic acid-templated transcription (GO:0097659)	1.91	5	TBP, ATXN3, CHCHD2, PARK2, NR4A2
response to endogenous stimulus (GO:0009719)	2.79	5	GBA, NR4A2, PARK2, SNCA, LRRK2
regulation of neurogenesis (GO:0050767)	3.21	5	EIF4G1, MAPT, PARK2, SYNJ1, LRRK2
regulation of cellular amide metabolic process (GO:0034248)	3.88	5	ATXN2, PLA2G6, GIGYF2, EIF4G1, PINK1
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	5	GBA, UCHL1, FBXO7, SNCA, LRRK2
positive regulation of hydrolase activity (GO:0051345)	2.91	5	SNCA, LRRK2, FGF20, PINK1, HTRA2
anatomical structure morphogenesis (GO:0009653)	2.53	5	GBA, NR4A2, MAPT, UCHL1, LRRK2
regulation of peptidase activity (GO:0052547)	3.75	5	ATP13A2, PARK7, HTRA2, PINK1, SNCA
protein modification by small protein conjugation or removal (GO:0070647)	2.95	5	FBXO7, ATXN3, UCHL1, PARK2, PINK1
negative regulation of oxidative stress-induced cell death (GO:1903202)	6.23	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
regulation of cell development (GO:0060284)	3.01	5	EIF4G1, MAPT, PARK2, SYNJ1, LRRK2
nitrogen compound transport (GO:0071705)	3.54	5	ATP13A2, PARK7, PARK2, SNCA, ATXN2
positive regulation of mitochondrion organization (GO:0010822)	4.61	5	PLA2G6, PARK2, PARK7, PINK1, HTRA2
regulation of nervous system development (GO:0051960)	3.1	5	EIF4G1, MAPT, PARK2, SYNJ1, LRRK2
organelle localization (GO:0051640)	3.94	5	SYNJ1, MAPT, UCHL1, LRRK2, SNCA
regulation of oxidative stress-induced cell death (GO:1903201)	5.9	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
regulation of proteasomal protein catabolic process (GO:0061136)	4.78	5	GBA, PARK7, PARK2, LRRK2, PINK1
system process (GO:0003008)	2.3	5	PARK2, PLA2G6, UCHL1, GIGYF2, SYNJ1
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	5	GBA, PARK7, PARK2, LRRK2, PINK1
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)	5.21	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
heterocycle biosynthetic process (GO:0018130)	1.7	5	TBP, PARK2, CHCHD2, ATXN3, NR4A2
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	5	TBP, NR4A2, PARK2, CHCHD2, PARK7
response to abiotic stimulus (GO:0009628)	2.8	5	GBA, NR4A2, ATXN3, HTRA2, PINK1
neurological system process (GO:0050877)	2.64	5	PARK2, PLA2G6, GIGYF2, UCHL1, SYNJ1
autophagy (GO:0006914)	3.82	5	FBXO7, PARK7, PARK2, LRRK2, PINK1
modification-dependent protein catabolic process (GO:0019941)	3.71	5	PARK2, ATXN3, UCHL1, FBXO7, PINK1
positive regulation of catabolic process (GO:0009896)	3.94	5	GBA, ATXN3, SNCA, PARK2, LRRK2
establishment of protein localization (GO:0045184)	2.53	5	DNAJC13, VPS35, FBXO7, VPS13C, PINK1
organophosphate metabolic process (GO:0019637)	3.04	5	PLA2G6, LRRK2, SYNJ1, FGF20, SNCA
positive regulation of RNA metabolic process (GO:0051254)	2.51	5	TBP, CHCHD2, PARK2, PARK7, NR4A2
cellular component disassembly (GO:0022411)	3.52	5	FBXO7, DNAJC6, PARK2, SYNJ1, PINK1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	5	TBP, NR4A2, PARK2, CHCHD2, PARK7
cation homeostasis (GO:0055080)	3.46	5	ATP13A2, PLA2G6, PARK2, SNCA, LRRK2
response to inorganic substance (GO:0010035)	3.56	5	ATP13A2, PARK7, PARK2, SNCA, LRRK2
regulation of response to oxidative stress (GO:1902882)	5.62	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
negative regulation of response to oxidative stress (GO:1902883)	6.23	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
oxidation-reduction process (GO:0055114)	2.91	5	PARK7, GLUD2, ADH1C, PINK1, SNCA
multi-organism process (GO:0051704)	2.65	5	TBP, PLA2G6, MAPT, PARK2, EIF4G1
locomotion (GO:0040011)	2.91	5	NR4A2, MAPT, PODXL, LRRK2, PLA2G6
single organism signaling (GO:0044700)	3.25	5	PARK2, PARK7, ATXN3, SNCA, FGF20
regulation of cellular response to oxidative stress (GO:1900407)	5.72	5	PARK7, PARK2, LRRK2, PINK1, HTRA2
vesicle-mediated transport (GO:0016192)	2.72	5	VPS13C, VPS35, SYNJ1, LRRK2, SNCA
intracellular transport (GO:0046907)	2.67	5	UCHL1, MAPT, FBXO7, VPS35, VPS13C
positive regulation of developmental process (GO:0051094)	2.77	5	EIF4G1, MAPT, PARK2, SYNJ1, PINK1
negative regulation of cellular response to oxidative stress (GO:1900408)	6.23	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
negative regulation of organelle organization (GO:0010639)	4.07	5	VPS13C, PARK2, LRRK2, PINK1, SNCA
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	5	TBP, NR4A2, PARK2, CHCHD2, PARK7
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	5	SNCA, CHCHD2, PARK2, NR4A2, PARK7
transcription, DNA-templated (GO:0006351)	1.91	5	TBP, PARK2, NR4A2, ATXN3, CHCHD2
ubiquitin-dependent protein catabolic process (GO:0006511)	3.72	5	PARK2, ATXN3, UCHL1, FBXO7, PINK1
signaling (GO:0023052)	3.25	5	PARK2, PARK7, ATXN3, SNCA, FGF20
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	4.74	5	PARK2, PARK7, LRRK2, HTRA2, PINK1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	5	TBP, PARK2, CHCHD2, ATXN3, NR4A2
regulation of neurotransmitter levels (GO:0001505)	4.77	5	PARK7, SNCAIP, PARK2, SNCA, LRRK2
regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032434)	5.05	4	GBA, PARK7, PARK2, LRRK2
regulation of homeostatic process (GO:0032844)	3.65	4	PLA2G6, LRRK2, PINK1, SNCA
establishment of organelle localization (GO:0051656)	4.15	4	UCHL1, MAPT, SYNJ1, SNCA
regulation of cell projection organization (GO:0031344)	3.38	4	PODXL, PARK2, MAPT, LRRK2
cellular macromolecule localization (GO:0070727)	3.1	4	PARK2, VPS13C, FBXO7, LRRK2
posttranscriptional regulation of gene expression (GO:0010608)	3.64	4	EIF4G1, GIGYF2, ATXN2, PINK1
cell projection morphogenesis (GO:0048858)	4.05	4	NR4A2, MAPT, UCHL1, LRRK2
regulation of neuron differentiation (GO:0045664)	3.39	4	EIF4G1, PARK2, MAPT, LRRK2
regulation of cellular amine metabolic process (GO:0033238)	5.42	4	NR4A2, PARK2, PARK7, SNCA
positive regulation of cell development (GO:0010720)	3.57	4	EIF4G1, MAPT, PARK2, SYNJ1
cellular homeostasis (GO:0019725)	3.23	4	ATP13A2, PLA2G6, PARK2, LRRK2
protein catabolic process (GO:0030163)	3.93	4	PARK2, UCHL1, ATXN3, HTRA2
response to metal ion (GO:0010038)	3.91	4	ATP13A2, SNCA, PARK2, LRRK2
neurotransmitter transport (GO:0006836)	5.07	4	PARK7, PARK2, SYNJ1, SNCA
cell motility (GO:0048870)	3.02	4	PODXL, MAPT, NR4A2, LRRK2
response to organonitrogen compound (GO:0010243)	3.2	4	NR4A2, PARK2, SNCA, LRRK2
anterograde trans-synaptic signaling (GO:0098916)	3.98	4	PARK2, PARK7, ATXN3, SNCA
cellular component assembly (GO:0022607)	2.14	4	SYNJ1, PARK2, LRRK2, ATXN2
negative regulation of biosynthetic process (GO:0009890)	2.47	4	PARK2, NR4A2, GIGYF2, SNCA
positive regulation of kinase activity (GO:0033674)	3.54	4	PARK7, LRRK2, PINK1, SNCA
regulation of neurotransmitter transport (GO:0051588)	5.55	4	SNCAIP, PARK2, SNCA, LRRK2
regulation of protein secretion (GO:0050708)	3.77	4	ATP13A2, PLA2G6, PARK2, VPS35
macromolecular complex assembly (GO:0065003)	2.55	4	SYNJ1, PARK2, LRRK2, ATXN2
negative regulation of MAPK cascade (GO:0043409)	4.74	4	GBA, UCHL1, PARK2, PINK1
cell migration (GO:0016477)	3.12	4	PODXL, MAPT, NR4A2, LRRK2
response to cytokine (GO:0034097)	3.84	4	GBA, SNCA, SYNJ1, HTRA2
regulation of catecholamine metabolic process (GO:0042069)	6.9	4	NR4A2, PARK2, PARK7, SNCA
catecholamine metabolic process (GO:0006584)	6.02	4	NR4A2, SNCAIP, PARK2, SNCA
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	4	PARK7, PARK2, SNCA, PINK1
regulation of protein complex assembly (GO:0043254)	3.83	4	PARK7, MAPT, PINK1, SNCA
response to nitrogen compound (GO:1901698)	3.12	4	NR4A2, PARK2, SNCA, LRRK2
cellular response to nitrogen compound (GO:1901699)	3.79	4	NR4A2, PARK2, SNCA, LRRK2
positive regulation of nervous system development (GO:0051962)	3.64	4	EIF4G1, MAPT, PARK2, SYNJ1
neuron projection morphogenesis (GO:0048812)	4.34	4	NR4A2, MAPT, UCHL1, LRRK2
presynaptic process involved in chemical synaptic transmission (GO:0099531)	4.98	4	PARK7, PARK2, SYNJ1, SNCA
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	4	PARK2, NR4A2, GIGYF2, SNCA
synaptic signaling (GO:0099536)	3.98	4	PARK2, PARK7, ATXN3, SNCA
trans-synaptic signaling (GO:0099537)	3.98	4	ATXN3, PARK7, PARK2, SNCA
regulation of developmental growth (GO:0048638)	4.04	4	MAPT, PARK2, FGF20, HTRA2
catechol-containing compound metabolic process (GO:0009712)	6.02	4	NR4A2, PARK2, SNCAIP, SNCA
cellular response to metal ion (GO:0071248)	4.81	4	ATP13A2, SNCA, PARK2, LRRK2
phosphorylation (GO:0016310)	2.63	4	ATP13A2, LRRK2, FGF20, PINK1
chemical synaptic transmission (GO:0007268)	3.98	4	PARK2, PARK7, ATXN3, SNCA
cellular response to inorganic substance (GO:0071241)	4.67	4	ATP13A2, SNCA, PARK2, LRRK2
negative regulation of synaptic transmission (GO:0050805)	5.67	4	PLA2G6, PARK2, SNCA, LRRK2
regulation of protein targeting (GO:1903533)	4.0	4	PARK2, LRRK2, HTRA2, PINK1
response to organic cyclic compound (GO:0014070)	3.07	4	GBA, SNCA, PARK2, LRRK2
divalent inorganic cation homeostasis (GO:0072507)	3.9	4	ATP13A2, PLA2G6, PARK2, SNCA
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	4	MAPT, PARK2, LRRK2, PINK1
positive regulation of neurogenesis (GO:0050769)	3.77	4	EIF4G1, MAPT, PARK2, SYNJ1
regulation of protein modification by small protein conjugation or removal (GO:1903320)	4.14	4	PARK7, PARK2, LRRK2, PINK1
cell projection organization (GO:0030030)	3.14	4	NR4A2, MAPT, UCHL1, LRRK2
regulation of protein ubiquitination (GO:0031396)	4.22	4	PARK7, PARK2, LRRK2, PINK1
regulation of exocytosis (GO:0017157)	4.59	4	ATP13A2, PLA2G6, SNCA, LRRK2
cellular response to endogenous stimulus (GO:0071495)	3.33	4	NR4A2, PARK2, SNCA, LRRK2
phospholipid metabolic process (GO:0006644)	3.88	4	PLA2G6, SYNJ1, FGF20, SNCA
positive regulation of cellular catabolic process (GO:0031331)	4.15	4	GBA, SNCA, PARK2, LRRK2
dopamine metabolic process (GO:0042417)	6.51	4	NR4A2, SNCAIP, PARK2, SNCA
regulation of establishment of protein localization to mitochondrion (GO:1903747)	4.88	4	PARK2, LRRK2, HTRA2, PINK1
regulation of neurotransmitter secretion (GO:0046928)	5.78	4	SNCAIP, PARK2, SNCA, LRRK2
phenol-containing compound metabolic process (GO:0018958)	5.33	4	NR4A2, SNCAIP, PARK2, SNCA
cell part morphogenesis (GO:0032990)	3.99	4	NR4A2, MAPT, UCHL1, LRRK2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	4	CHCHD2, PARK2, NR4A2, PARK7
protein localization to organelle (GO:0033365)	3.57	4	FBXO7, VPS13C, PARK2, LRRK2
positive regulation of protein kinase activity (GO:0045860)	3.61	4	PARK7, LRRK2, PINK1, SNCA
response to extracellular stimulus (GO:0009991)	3.71	4	GBA, NR4A2, MAPT, LRRK2
regulation of dopamine metabolic process (GO:0042053)	6.9	4	NR4A2, PARK2, PARK7, SNCA
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	4	NR4A2, PARK2, GIGYF2, SNCA
response to transition metal nanoparticle (GO:1990267)	4.7	4	ATP13A2, SNCA, PARK2, LRRK2
protein transport (GO:0015031)	2.62	4	DNAJC13, VPS35, FBXO7, VPS13C
negative regulation of mitochondrion organization (GO:0010823)	6.07	4	VPS13C, PARK2, LRRK2, PINK1
cell death (GO:0008219)	3.05	4	MAPT, LRRK2, SNCAIP, HTRA2
protein complex subunit organization (GO:0071822)	2.6	4	DNAJC6, PARK2, SYNJ1, LRRK2
positive regulation of protein catabolic process (GO:0045732)	4.18	4	GBA, ATXN3, PARK2, LRRK2
response to lipid (GO:0033993)	3.11	4	GBA, SYNJ1, SNCA, HTRA2
regulation of growth (GO:0040008)	3.26	4	MAPT, PARK2, FGF20, HTRA2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	4	PARK2, NR4A2, GIGYF2, SNCA
cellular component morphogenesis (GO:0032989)	3.5	4	NR4A2, MAPT, UCHL1, LRRK2
positive regulation of autophagy (GO:0010508)	5.41	4	GBA, PARK7, LRRK2, PINK1
negative regulation of autophagy (GO:0010507)	5.76	4	VPS13C, LRRK2, PINK1, SNCA
protein phosphorylation (GO:0006468)	2.89	4	ATP13A2, FGF20, LRRK2, PINK1
negative regulation of protein kinase activity (GO:0006469)	4.29	4	GBA, PARK7, FBXO7, UCHL1
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	6.68	4	PARK7, PARK2, HTRA2, PINK1
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)	6.36	4	PARK7, PARK2, HTRA2, PINK1
regulation of endopeptidase activity (GO:0052548)	3.8	4	ATP13A2, PARK7, SNCA, HTRA2
cellular protein localization (GO:0034613)	3.11	4	FBXO7, VPS13C, PARK2, LRRK2
reproductive process (GO:0022414)	2.55	4	TBP, PLA2G6, MAPT, PARK7
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	NR4A2, PARK2, GIGYF2, SNCA
metal ion homeostasis (GO:0055065)	3.61	4	ATP13A2, PLA2G6, PARK2, SNCA
positive regulation of transferase activity (GO:0051347)	3.31	4	PARK7, LRRK2, PINK1, SNCA
regulation of endocytosis (GO:0030100)	4.42	4	SYNJ1, DNAJC6, ATXN2, SNCA
lipid biosynthetic process (GO:0008610)	3.49	4	GBA, PLA2G6, SYNJ1, FGF20
positive regulation of cell differentiation (GO:0045597)	3.01	4	EIF4G1, MAPT, PARK2, SYNJ1
regulation of mitochondrial membrane potential (GO:0051881)	5.72	4	PARK7, PARK2, LRRK2, PINK1
regulation of protein targeting to mitochondrion (GO:1903214)	5.14	4	PARK2, LRRK2, PINK1, HTRA2
regulation of synaptic vesicle transport (GO:1902803)	6.29	4	SNCA, PARK2, LRRK2, PINK1
regulation of translation (GO:0006417)	3.96	4	EIF4G1, GIGYF2, ATXN2, PINK1
single-organism cellular localization (GO:1902580)	3.16	4	SYNJ1, MAPT, UCHL1, SNCA
cellular response to organonitrogen compound (GO:0071417)	3.87	4	NR4A2, PARK2, SNCA, LRRK2
axonogenesis (GO:0007409)	4.74	3	NR4A2, MAPT, UCHL1
catecholamine uptake involved in synaptic transmission (GO:0051934)	8.12	3	PARK7, PARK2, SNCA
negative regulation of intracellular transport (GO:0032387)	5.02	3	PARK7, MAPT, LRRK2
cell development (GO:0048468)	3.28	3	PODXL, UCHL1, HTRA2
activation of protein kinase activity (GO:0032147)	4.08	3	PARK7, LRRK2, PINK1
learning or memory (GO:0007611)	4.33	3	PLA2G6, PARK2, SYNJ1
regulation of ATP metabolic process (GO:1903578)	5.82	3	PARK7, SNCA, PINK1
regulation of Wnt signaling pathway (GO:0030111)	3.98	3	VPS35, PARK2, LRRK2
protein autophosphorylation (GO:0046777)	4.46	3	ATP13A2, LRRK2, PINK1
calcium ion homeostasis (GO:0055074)	3.97	3	ATP13A2, PLA2G6, SNCA
small molecule catabolic process (GO:0044282)	3.99	3	PARK7, GLUD2, SYNJ1
small molecule biosynthetic process (GO:0044283)	3.79	3	GBA, PARK7, GLUD2
response to manganese ion (GO:0010042)	6.84	3	ATP13A2, PARK2, LRRK2
negative regulation of response to endoplasmic reticulum stress (GO:1903573)	6.07	3	PARK7, PARK2, LRRK2
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	3	NR4A2, VPS35, LRRK2
regulation of transmembrane transport (GO:0034762)	3.74	3	PLA2G6, PARK7, SNCA
negative regulation of cell cycle (GO:0045786)	3.67	3	GIGYF2, FBXO7, HTRA2
regulation of cytoskeleton organization (GO:0051493)	3.72	3	MAPT, PARK2, SNCA
interspecies interaction between organisms (GO:0044419)	3.08	3	TBP, EIF4G1, PARK2
protein modification by small protein conjugation (GO:0032446)	3.1	3	PARK2, FBXO7, PINK1
regulation of hydrogen peroxide-induced cell death (GO:1903205)	6.78	3	PARK7, LRRK2, PINK1
positive regulation of neuron differentiation (GO:0045666)	3.98	3	EIF4G1, PARK2, MAPT
regulation of oxidative stress-induced neuron death (GO:1903203)	7.33	3	PARK7, PARK2, PINK1
regulation of amine transport (GO:0051952)	5.62	3	SNCA, PARK2, PINK1
regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902956)	8.34	3	PARK7, SNCA, PINK1
monoamine transport (GO:0015844)	6.64	3	PARK7, PARK2, SNCA
regulation of neuron projection development (GO:0010975)	3.69	3	MAPT, PARK2, LRRK2
oxoacid metabolic process (GO:0043436)	3.12	3	PARK7, GLUD2, SNCA
glycerolipid metabolic process (GO:0046486)	3.91	3	PLA2G6, SYNJ1, FGF20
dopamine transport (GO:0015872)	7.33	3	PARK7, PARK2, SNCA
protein localization to mitochondrion (GO:0070585)	5.74	3	PARK2, FBXO7, LRRK2
cellular response to extracellular stimulus (GO:0031668)	4.57	3	GBA, NR4A2, LRRK2
single organism reproductive process (GO:0044702)	2.73	3	TBP, PLA2G6, PARK7
organic acid metabolic process (GO:0006082)	3.01	3	PARK7, GLUD2, SNCA
cellular response to manganese ion (GO:0071287)	7.43	3	ATP13A2, PARK2, LRRK2
Wnt signaling pathway (GO:0016055)	3.88	3	NR4A2, VPS35, LRRK2
response to nutrient levels (GO:0031667)	3.77	3	GBA, MAPT, LRRK2
immune system process (GO:0002376)	2.29	3	PODXL, PLA2G6, SNCA
protein ubiquitination (GO:0016567)	3.28	3	PARK2, FBXO7, PINK1
neurotransmitter uptake (GO:0001504)	7.02	3	PARK7, PARK2, SNCA
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903377)	8.12	3	PARK7, PARK2, PINK1
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	NR4A2, PARK2, SNCA
regulation of canonical Wnt signaling pathway (GO:0060828)	4.26	3	VPS35, PARK2, LRRK2
regulation of cell morphogenesis (GO:0022604)	3.4	3	MAPT, PARK2, LRRK2
organic hydroxy compound transport (GO:0015850)	4.96	3	PARK7, PARK2, SNCA
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235)	6.33	3	PARK7, PARK2, LRRK2
organelle disassembly (GO:1903008)	4.52	3	FBXO7, PARK2, PINK1
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236)	6.78	3	PARK7, PARK2, LRRK2
protein stabilization (GO:0050821)	4.86	3	PARK7, PARK2, PINK1
dopamine uptake involved in synaptic transmission (GO:0051583)	8.12	3	PARK7, PARK2, SNCA
response to monoamine (GO:0071867)	6.17	3	SNCA, PARK2, LRRK2
cellular response to monoamine stimulus (GO:0071868)	6.29	3	SNCA, PARK2, LRRK2
response to catecholamine (GO:0071869)	6.23	3	SNCA, PARK2, LRRK2
negative regulation of protein serine/threonine kinase activity (GO:0071901)	4.92	3	GBA, UCHL1, FBXO7
negative regulation of protein transport (GO:0051224)	4.44	3	PARK7, PARK2, LRRK2
regulation of cellular respiration (GO:0043457)	6.68	3	PARK7, SNCA, PINK1
regulation of oxidoreductase activity (GO:0051341)	5.27	3	PARK7, PARK2, SNCA
negative regulation of hydrolase activity (GO:0051346)	3.74	3	PARK7, SNCA, LRRK2
intracellular protein transport (GO:0006886)	3.2	3	VPS35, FBXO7, VPS13C
regulation of anatomical structure size (GO:0090066)	3.78	3	ATP13A2, PLA2G6, LRRK2
regulation of immune system process (GO:0002682)	2.5	3	PLA2G6, FBXO7, SNCA
synaptic transmission, dopaminergic (GO:0001963)	7.02	3	PARK7, PARK2, SNCA
dopamine uptake (GO:0090494)	8.12	3	PARK7, PARK2, SNCA
catecholamine uptake (GO:0090493)	8.12	3	PARK7, PARK2, SNCA
regulation of release of cytochrome c from mitochondria (GO:0090199)	5.94	3	PLA2G6, PARK2, PINK1
adult walking behavior (GO:0007628)	6.23	3	UCHL1, MAPT, HTRA2
defense response (GO:0006952)	2.78	3	PLA2G6, EIF4G1, PARK7
glycerophospholipid biosynthetic process (GO:0046474)	4.62	3	PLA2G6, SYNJ1, FGF20
regulation of receptor-mediated endocytosis (GO:0048259)	5.35	3	DNAJC6, SYNJ1, ATXN2
organophosphate biosynthetic process (GO:0090407)	3.67	3	PLA2G6, SYNJ1, FGF20
endocytosis (GO:0006897)	3.69	3	SYNJ1, SNCA, LRRK2
positive regulation of protein secretion (GO:0050714)	4.39	3	ATP13A2, PLA2G6, VPS35
cognition (GO:0050890)	4.2	3	PLA2G6, PARK2, SYNJ1
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903376)	7.78	3	PARK7, PARK2, PINK1
cellular amide metabolic process (GO:0043603)	3.23	3	GBA, EIF4G1, HTRA2
organic hydroxy compound biosynthetic process (GO:1901617)	4.98	3	GBA, NR4A2, SNCA
regulation of nucleotide metabolic process (GO:0006140)	4.38	3	PARK7, SNCA, PINK1
cellular response to catecholamine stimulus (GO:0071870)	6.33	3	SNCA, PARK2, LRRK2
regulation of MAP kinase activity (GO:0043405)	3.95	3	GBA, UCHL1, LRRK2
proteasomal protein catabolic process (GO:0010498)	4.12	3	PARK2, UCHL1, ATXN3
negative regulation of establishment of protein localization (GO:1904950)	4.39	3	PARK7, PARK2, LRRK2
regulation of catecholamine secretion (GO:0050433)	5.99	3	SNCA, PARK2, PINK1
positive regulation of cellular protein localization (GO:1903829)	3.85	3	PARK7, HTRA2, PINK1
positive regulation of peptidase activity (GO:0010952)	4.7	3	SNCA, HTRA2, PINK1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	3	NR4A2, PARK2, SNCA
proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)	4.16	3	PARK2, UCHL1, ATXN3
positive regulation of protein modification by small protein conjugation or removal (GO:1903322)	4.48	3	PARK2, LRRK2, PINK1
regulation of transporter activity (GO:0032409)	4.45	3	PLA2G6, PARK7, SNCA
negative regulation of oxidative stress-induced neuron death (GO:1903204)	7.65	3	PARK7, PARK2, PINK1
regulation of protein polymerization (GO:0032271)	4.57	3	MAPT, SNCA, PINK1
positive regulation of protein ubiquitination (GO:0031398)	4.55	3	PARK2, LRRK2, PINK1
cellular response to external stimulus (GO:0071496)	4.2	3	GBA, NR4A2, LRRK2
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	3	GBA, PARK2, LRRK2
establishment of protein localization to organelle (GO:0072594)	3.92	3	VPS13C, FBXO7, PINK1
cellular ion homeostasis (GO:0006873)	3.57	3	ATP13A2, PLA2G6, LRRK2
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	NR4A2, PARK2, SNCA
cellular response to DNA damage stimulus (GO:0006974)	3.17	3	GIGYF2, ATXN3, HTRA2
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	3	PARK7, SNCA, HTRA2
regulation of locomotion (GO:0040012)	3.12	3	PODXL, SNCA, LRRK2
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	NR4A2, PARK2, SNCA
cellular cation homeostasis (GO:0030003)	3.6	3	ATP13A2, PLA2G6, LRRK2
cellular chemical homeostasis (GO:0055082)	3.4	3	ATP13A2, PLA2G6, LRRK2
negative regulation of developmental process (GO:0051093)	3.17	3	PARK2, FBXO7, PINK1
vacuole organization (GO:0007033)	4.67	3	ATP13A2, DNAJC13, LRRK2
phospholipid biosynthetic process (GO:0008654)	4.39	3	PLA2G6, SYNJ1, FGF20
mitophagy (GO:0000422)	4.63	3	PARK2, FBXO7, PINK1
neurotransmitter reuptake (GO:0098810)	7.53	3	PARK7, PARK2, SNCA
cellular response to organic cyclic compound (GO:0071407)	3.93	3	SNCA, PARK2, LRRK2
positive regulation of binding (GO:0051099)	4.88	3	PARK7, PARK2, LRRK2
regulation of binding (GO:0051098)	4.08	3	PARK7, PARK2, LRRK2
regulation of vacuolar transport (GO:1903335)	6.36	3	DNAJC13, VPS35, LRRK2
negative regulation of response to reactive oxygen species (GO:1901032)	6.96	3	PARK7, LRRK2, PINK1
regulation of response to reactive oxygen species (GO:1901031)	6.29	3	PARK7, LRRK2, PINK1
system development (GO:0048731)	2.92	3	PARK2, NR4A2, ATXN3
negative regulation of proteolysis (GO:0045861)	3.98	3	PARK7, SNCA, LRRK2
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	3	PARK7, SNCA, PINK1
glycerophospholipid metabolic process (GO:0006650)	4.13	3	PLA2G6, SYNJ1, FGF20
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	3	PARK7, SNCA, PINK1
cellular macromolecular complex assembly (GO:0034622)	3.18	3	SYNJ1, PARK2, ATXN2
carboxylic acid metabolic process (GO:0019752)	3.12	3	PARK7, GLUD2, SNCA
negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	6.96	3	PARK7, LRRK2, PINK1
regulation of oxidative phosphorylation (GO:0002082)	6.96	3	PARK7, SNCA, PINK1
neuromuscular process (GO:0050905)	5.27	3	UCHL1, PARK2, GIGYF2
neuron-neuron synaptic transmission (GO:0007270)	5.74	3	PARK7, PARK2, SNCA
regulation of dopamine secretion (GO:0014059)	6.64	3	SNCA, PARK2, PINK1
regulation of ion transport (GO:0043269)	3.4	3	PLA2G6, PARK7, SNCA
regulation of purine nucleotide metabolic process (GO:1900542)	4.41	3	PARK7, SNCA, PINK1
glycerolipid biosynthetic process (GO:0045017)	4.53	3	PLA2G6, SYNJ1, FGF20
regulation of generation of precursor metabolites and energy (GO:0043467)	5.24	3	PARK7, SNCA, PINK1
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	3	PARK7, SNCA, HTRA2
regulation of mitochondrial fission (GO:0090140)	6.84	3	PARK2, LRRK2, PINK1
response to toxic substance (GO:0009636)	4.88	3	PARK2, HTRA2, PINK1
catecholamine transport (GO:0051937)	7.09	3	PARK7, PARK2, SNCA
regulation of organelle assembly (GO:1902115)	4.7	3	LRRK2, ATXN2, PINK1
negative regulation of macroautophagy (GO:0016242)	6.68	3	VPS13C, LRRK2, PINK1
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	3	GBA, PARK2, LRRK2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	NR4A2, PARK2, SNCA
neuron differentiation (GO:0030182)	4.17	3	NR4A2, GIGYF2, FGF20
mitochondrion disassembly (GO:0061726)	4.63	3	PARK2, FBXO7, PINK1
protein complex assembly (GO:0006461)	2.78	3	SYNJ1, PARK2, LRRK2
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	NR4A2, PARK2, SNCA
multi-organism cellular process (GO:0044764)	3.14	3	TBP, EIF4G1, PARK2
import into cell (GO:0098657)	6.12	3	PARK7, PARK2, SNCA
mitochondrion localization (GO:0051646)	6.15	3	UCHL1, MAPT, LRRK2
regulation of nucleoside metabolic process (GO:0009118)	5.82	3	PARK7, SNCA, PINK1
positive regulation of ion transport (GO:0043270)	4.36	3	PLA2G6, PARK7, SNCA
microtubule-based process (GO:0007017)	3.54	3	UCHL1, ATXN3, MAPT
regulation of cell cycle (GO:0051726)	2.93	3	GIGYF2, FBXO7, HTRA2
walking behavior (GO:0090659)	6.23	3	UCHL1, MAPT, HTRA2
alcohol metabolic process (GO:0006066)	4.2	3	GBA, SYNJ1, ADH1C
viral process (GO:0016032)	3.15	3	TBP, EIF4G1, PARK2
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	3	TBP, EIF4G1, PARK2
regulation of vacuole organization (GO:0044088)	6.02	3	SYNJ1, LRRK2, PINK1
regulation of peptide transport (GO:0090087)	4.37	2	PLA2G6, PARK2
regulation of chaperone-mediated autophagy (GO:1904714)	7.78	2	ATP13A2, SNCA
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	PARK7, HTRA2
response to growth factor (GO:0070848)	4.14	2	SNCA, HTRA2
positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)	5.47	2	PARK2, LRRK2
developmental growth (GO:0048589)	4.05	2	MAPT, GIGYF2
anatomical structure homeostasis (GO:0060249)	4.25	2	GIGYF2, PARK2
negative regulation of secretion (GO:0051048)	4.44	2	SNCA, PARK2
cellular response to heat (GO:0034605)	6.17	2	ATXN3, HTRA2
learning (GO:0007612)	4.85	2	SYNJ1, PARK2
activation of protein kinase B activity (GO:0032148)	6.51	2	PARK7, PINK1
mitophagy in response to mitochondrial depolarization (GO:0098779)	4.85	2	PARK2, PINK1
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	4.97	2	SNCA, LRRK2
positive regulation of cellular respiration (GO:1901857)	8.34	2	PARK7, PINK1
protein complex disassembly (GO:0043241)	4.58	2	DNAJC6, SYNJ1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	GIGYF2, FGF20
positive regulation of transmembrane transport (GO:0034764)	4.99	2	PARK7, SNCA
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	2	GIGYF2, FGF20
lipid catabolic process (GO:0016042)	4.21	2	GBA, PLA2G6
maintenance of location in cell (GO:0051651)	5.13	2	VPS13C, PINK1
establishment of vesicle localization (GO:0051650)	4.91	2	SYNJ1, SNCA
regulation of defense response (GO:0031347)	3.11	2	GBA, PARK7
positive regulation of cell projection organization (GO:0031346)	3.99	2	MAPT, PARK2
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267)	6.64	2	PARK7, HTRA2
regulation of hydrogen peroxide metabolic process (GO:0010310)	7.02	2	SNCA, PINK1
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	2	GIGYF2, FBXO7
response to external biotic stimulus (GO:0043207)	3.13	2	PLA2G6, SNCA
negative regulation of cytoskeleton organization (GO:0051494)	5.01	2	SNCA, PARK2
MAPK cascade (GO:0000165)	3.91	2	LRRK2, FGF20
protein modification by small protein removal (GO:0070646)	4.83	2	UCHL1, ATXN3
regulation of cytokine production (GO:0001817)	3.4	2	GBA, PARK7
regulation of hydrogen peroxide-induced neuron death (GO:1903207)	8.34	2	PARK7, PINK1
electron transport chain (GO:0022900)	5.09	2	SNCA, PINK1
positive regulation of release of cytochrome c from mitochondria (GO:0090200)	6.4	2	PLA2G6, PINK1
respiratory electron transport chain (GO:0022904)	5.11	2	SNCA, PINK1
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	2	TBP, PARK2
synaptic vesicle localization (GO:0097479)	5.31	2	SYNJ1, SNCA
positive regulation of establishment of protein localization to mitochondrion (GO:1903749)	4.98	2	HTRA2, PINK1
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	2	MAPT, LRRK2
sphingolipid metabolic process (GO:0006665)	4.79	2	GBA, HTRA2
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	2	PARK2, PINK1
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	2	PARK2, PINK1
regulation of cell proliferation (GO:0042127)	2.41	2	LRRK2, FGF20
positive regulation of proteasomal protein catabolic process (GO:1901800)	5.29	2	PARK2, LRRK2
clathrin-mediated endocytosis (GO:0072583)	6.15	2	SYNJ1, SNCA
regulation of microtubule polymerization (GO:0031113)	6.4	2	MAPT, SNCA
maintenance of protein location (GO:0045185)	5.21	2	VPS13C, PINK1
positive regulation of protein targeting to mitochondrion (GO:1903955)	5.26	2	HTRA2, PINK1
establishment of localization by movement along microtubule (GO:0010970)	5.14	2	UCHL1, MAPT
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	SYNJ1, FGF20
regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway (GO:1903383)	9.04	2	PARK7, PINK1
establishment of protein localization to mitochondrion (GO:0072655)	5.63	2	FBXO7, PINK1
peptidyl-serine modification (GO:0018209)	4.72	2	LRRK2, PINK1
establishment of synaptic vesicle localization (GO:0097480)	5.33	2	SYNJ1, SNCA
endosomal transport (GO:0016197)	4.28	2	VPS35, VPS13C
post-embryonic development (GO:0009791)	5.35	2	NR4A2, GIGYF2
regulation of synaptic transmission, dopaminergic (GO:0032225)	6.9	2	SNCA, PINK1
cellular response to nutrient levels (GO:0031669)	4.7	2	GBA, LRRK2
response to biotic stimulus (GO:0009607)	3.09	2	PLA2G6, SNCA
organonitrogen compound catabolic process (GO:1901565)	3.91	2	GBA, GLUD2
negative regulation of oxidoreductase activity (GO:0051354)	6.51	2	SNCA, PARK2
regulation of late endosome to lysosome transport (GO:1902822)	8.34	2	VPS35, LRRK2
negative regulation of late endosome to lysosome transport (GO:1902823)	9.04	2	VPS35, LRRK2
organic acid biosynthetic process (GO:0016053)	4.26	2	PARK7, GLUD2
positive regulation of oxidoreductase activity (GO:0051353)	5.94	2	PARK7, SNCA
negative regulation of protein catabolic process (GO:0042177)	5.24	2	ATP13A2, PARK7
positive regulation of oxidative phosphorylation (GO:1903862)	7.94	2	PARK7, PINK1
multicellular organismal response to stress (GO:0033555)	5.67	2	NR4A2, EIF4G1
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	2	GIGYF2, FBXO7
regulation of microtubule cytoskeleton organization (GO:0070507)	4.98	2	MAPT, SNCA
ceramide metabolic process (GO:0006672)	5.41	2	GBA, HTRA2
negative regulation of mitophagy (GO:1903147)	8.34	2	VPS13C, PINK1
feeding behavior (GO:0007631)	5.21	2	UCHL1, GIGYF2
positive regulation of homeostatic process (GO:0032846)	4.38	2	PLA2G6, SNCA
negative regulation of catabolic process (GO:0009895)	4.81	2	ATP13A2, PARK7
positive regulation of canonical Wnt signaling pathway (GO:0090263)	4.95	2	VPS35, LRRK2
regulation of cation transmembrane transport (GO:1904062)	4.4	2	PLA2G6, SNCA
transition metal ion homeostasis (GO:0055076)	5.09	2	ATP13A2, PARK2
regulation of DNA binding (GO:0051101)	5.21	2	PARK7, PARK2
negative regulation of binding (GO:0051100)	4.85	2	PARK7, LRRK2
positive regulation of cellular response to oxidative stress (GO:1900409)	7.16	2	PARK7, PARK2
regulation of neurotransmitter uptake (GO:0051580)	7.02	2	SNCA, PARK2
positive regulation of Wnt signaling pathway (GO:0030177)	4.7	2	VPS35, LRRK2
neuron migration (GO:0001764)	5.0	2	NR4A2, MAPT
establishment of mitochondrion localization (GO:0051654)	6.9	2	UCHL1, MAPT
positive regulation of DNA binding (GO:0043388)	6.02	2	PARK7, PARK2
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	SNCA, LRRK2
catecholamine biosynthetic process (GO:0042423)	6.9	2	NR4A2, SNCA
establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	7.02	2	UCHL1, MAPT
synaptic vesicle transport (GO:0048489)	5.33	2	SYNJ1, SNCA
negative regulation of protein binding (GO:0032091)	5.36	2	PARK7, LRRK2
regulation of mitotic cell cycle (GO:0007346)	3.71	2	GIGYF2, FBXO7
positive regulation of GTPase activity (GO:0043547)	3.28	2	LRRK2, FGF20
negative regulation of vacuolar transport (GO:1903336)	8.34	2	VPS35, LRRK2
positive regulation of protein kinase B signaling (GO:0051897)	5.32	2	PARK7, PINK1
negative regulation of cellular protein catabolic process (GO:1903363)	5.92	2	ATP13A2, PARK7
positive regulation of nucleotide metabolic process (GO:0045981)	4.85	2	PARK7, PINK1
cellular response to topologically incorrect protein (GO:0035967)	7.43	2	PARK2, ATXN3
axo-dendritic transport (GO:0008088)	6.12	2	UCHL1, MAPT
regulation of protein kinase B signaling (GO:0051896)	4.92	2	PARK7, PINK1
exploration behavior (GO:0035640)	6.55	2	ATXN3, LRRK2
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	LRRK2, FGF20
transcription initiation from RNA polymerase II promoter (GO:0006367)	4.7	2	TBP, NR4A2
transcription from RNA polymerase II promoter (GO:0006366)	3.38	2	TBP, NR4A2
positive regulation of intracellular transport (GO:0032388)	4.08	2	HTRA2, PINK1
protein deubiquitination (GO:0016579)	4.97	2	UCHL1, ATXN3
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway (GO:1903384)	9.04	2	PARK7, PINK1
negative regulation of reactive oxygen species metabolic process (GO:2000378)	5.99	2	PARK2, PINK1
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	2	PARK7, SNCA
regulation of monooxygenase activity (GO:0032768)	5.69	2	PARK7, SNCA
regulation of insulin secretion (GO:0050796)	4.57	2	PLA2G6, PARK2
vesicle localization (GO:0051648)	4.85	2	SYNJ1, SNCA
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	HTRA2, PINK1
positive regulation of MAPK cascade (GO:0043410)	3.57	2	LRRK2, FGF20
canonical Wnt signaling pathway (GO:0060070)	5.26	2	NR4A2, LRRK2
negative regulation of protein acetylation (GO:1901984)	6.73	2	PARK7, SNCA
regulation of protein binding (GO:0043393)	4.6	2	PARK7, LRRK2
regulation of protein acetylation (GO:1901983)	5.59	2	PARK7, SNCA
cellular response to starvation (GO:0009267)	4.98	2	GBA, LRRK2
response to temperature stimulus (GO:0009266)	4.71	2	ATXN3, HTRA2
excitatory postsynaptic potential (GO:0060079)	6.43	2	SNCA, LRRK2
regulation of postsynaptic membrane potential (GO:0060078)	5.72	2	SNCA, LRRK2
maintenance of location (GO:0051235)	4.77	2	VPS13C, PINK1
negative regulation of peptidase activity (GO:0010466)	4.22	2	PARK7, SNCA
positive regulation of protein dephosphorylation (GO:0035307)	6.26	2	GBA, PINK1
positive regulation of dephosphorylation (GO:0035306)	5.92	2	GBA, PINK1
zinc ion homeostasis (GO:0055069)	6.78	2	ATP13A2, PARK2
regulation of ion transmembrane transport (GO:0034765)	3.77	2	PLA2G6, SNCA
brain development (GO:0007420)	4.24	2	SYNJ1, MAPT
regulation of lipid transport (GO:0032368)	5.21	2	PLA2G6, PARK2
programmed cell death (GO:0012501)	3.1	2	MAPT, HTRA2
carboxylic acid biosynthetic process (GO:0046394)	4.32	2	PARK7, GLUD2
regulation of transmembrane transporter activity (GO:0022898)	4.52	2	PLA2G6, PARK7
receptor-mediated endocytosis (GO:0006898)	4.31	2	SYNJ1, SNCA
organelle transport along microtubule (GO:0072384)	5.63	2	UCHL1, MAPT
regulation of leukocyte activation (GO:0002694)	3.6	2	SNCA, FBXO7
regulation of synaptic transmission, glutamatergic (GO:0051966)	5.82	2	PLA2G6, LRRK2
DNA-templated transcription, initiation (GO:0006352)	4.49	2	TBP, NR4A2
monocarboxylic acid metabolic process (GO:0032787)	3.57	2	PARK7, SNCA
response to endoplasmic reticulum stress (GO:0034976)	4.46	2	PLA2G6, PARK2
regulation of carbohydrate metabolic process (GO:0006109)	4.57	2	SNCA, PARK2
catechol-containing compound biosynthetic process (GO:0009713)	6.9	2	NR4A2, SNCA
regulation of hydrogen peroxide-mediated programmed cell death (GO:1901298)	7.65	2	PARK7, PINK1
negative regulation of hydrogen peroxide-mediated programmed cell death (GO:1901299)	7.94	2	PARK7, PINK1
positive regulation of developmental growth (GO:0048639)	4.67	2	MAPT, PARK2
synapse organization (GO:0050808)	4.87	2	SNCA, LRRK2
regulation of autophagosome assembly (GO:2000785)	6.2	2	LRRK2, PINK1
regulation of response to external stimulus (GO:0032101)	3.06	2	GBA, PARK7
dephosphorylation (GO:0016311)	4.06	2	DNAJC6, SYNJ1
positive regulation of cell growth (GO:0030307)	4.73	2	MAPT, PARK2
regulation of cell adhesion (GO:0030155)	3.27	2	PODXL, ATXN3
(GO:0099003)	5.51	2	SYNJ1, SNCA
positive regulation of synaptic transmission (GO:0050806)	5.07	2	SNCA, PINK1
regulation of inflammatory response (GO:0050727)	4.03	2	GBA, PARK7
negative regulation of MAP kinase activity (GO:0043407)	5.42	2	GBA, UCHL1
positive regulation of exocytosis (GO:0045921)	5.41	2	ATP13A2, PLA2G6
negative regulation of secretion by cell (GO:1903531)	4.55	2	SNCA, PARK2
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	2	GIGYF2, FBXO7
regulation of microtubule-based process (GO:0032886)	4.79	2	MAPT, SNCA
response to hypoxia (GO:0001666)	4.13	2	NR4A2, PINK1
regulation of GTPase activity (GO:0043087)	3.21	2	LRRK2, FGF20
regulation of dephosphorylation (GO:0035303)	4.67	2	GBA, PINK1
vesicle uncoating (GO:0072319)	8.34	2	DNAJC6, SYNJ1
negative regulation of cellular protein localization (GO:1903828)	4.82	2	PARK7, LRRK2
small GTPase mediated signal transduction (GO:0007264)	3.85	2	PARK7, LRRK2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	ATP13A2, PLA2G6
protein targeting (GO:0006605)	4.08	2	VPS13C, FBXO7
mitochondrion transport along microtubule (GO:0047497)	7.02	2	UCHL1, MAPT
regulation of cell cycle process (GO:0010564)	3.5	2	GIGYF2, FBXO7
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	2	UCHL1, MAPT
animal organ development (GO:0048513)	2.53	2	SYNJ1, MAPT
positive regulation of nucleoside metabolic process (GO:0045979)	6.55	2	PARK7, PINK1
negative regulation of cell cycle phase transition (GO:1901988)	4.74	2	GIGYF2, FBXO7
positive regulation of protein polymerization (GO:0032273)	5.24	2	MAPT, PINK1
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	5.76	2	PARK7, PARK2
regulation of cell cycle phase transition (GO:1901987)	4.15	2	GIGYF2, FBXO7
cellular response to toxic substance (GO:0097237)	7.53	2	PARK2, PINK1
central nervous system neuron differentiation (GO:0021953)	5.17	2	NR4A2, GIGYF2
membrane lipid metabolic process (GO:0006643)	4.51	2	GBA, HTRA2
cellular metal ion homeostasis (GO:0006875)	3.75	2	ATP13A2, PLA2G6
macroautophagy (GO:0016236)	4.3	2	PARK2, PINK1
negative regulation of protein complex assembly (GO:0031333)	5.07	2	PARK7, SNCA
positive regulation of protein complex assembly (GO:0031334)	4.44	2	MAPT, PINK1
regulation of cellular response to hypoxia (GO:1900037)	7.33	2	CHCHD2, PINK1
reactive oxygen species metabolic process (GO:0072593)	5.14	2	PARK7, LRRK2
regulation of stress-activated MAPK cascade (GO:0032872)	4.45	2	PARK2, PINK1
dopamine biosynthetic process (GO:0042416)	7.43	2	NR4A2, SNCA
regulation of cell growth (GO:0001558)	3.75	2	MAPT, PARK2
positive regulation of neurotransmitter transport (GO:0051590)	6.96	2	SNCA, PARK2
response to acid chemical (GO:0001101)	4.05	2	SYNJ1, HTRA2
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	SYNJ1, FGF20
cellular protein catabolic process (GO:0044257)	6.51	2	PARK2, HTRA2
response to heat (GO:0009408)	5.24	2	ATXN3, HTRA2
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	MAPT, HTRA2
lipid modification (GO:0030258)	4.37	2	SYNJ1, FGF20
cytosolic transport (GO:0016482)	4.98	2	VPS35, VPS13C
amide biosynthetic process (GO:0043604)	3.6	2	GBA, EIF4G1
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	PARK7, PINK1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	PARK7, PINK1
cellular response to growth factor stimulus (GO:0071363)	4.27	2	SNCA, HTRA2
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	GIGYF2, FBXO7
vacuolar transport (GO:0007034)	4.18	2	VPS35, VPS13C
macromitophagy (GO:0000423)	4.85	2	PARK2, PINK1
response to hormone (GO:0009725)	3.33	2	GBA, NR4A2
carbohydrate derivative metabolic process (GO:1901135)	3.07	2	GBA, LRRK2
response to drug (GO:0042493)	3.71	2	PARK7, SNCA
negative regulation of autophagosome assembly (GO:1902902)	7.43	2	LRRK2, PINK1
negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	6.02	2	PARK2, PINK1
cellular response to cytokine stimulus (GO:0071345)	4.33	2	GBA, HTRA2
regulation of protein dephosphorylation (GO:0035304)	5.31	2	GBA, PINK1
response to topologically incorrect protein (GO:0035966)	5.45	2	PARK2, ATXN3
positive regulation of oxidative stress-induced cell death (GO:1903209)	7.33	2	PARK7, PARK2
response to decreased oxygen levels (GO:0036293)	4.09	2	NR4A2, PINK1
microtubule cytoskeleton organization (GO:0000226)	4.13	2	MAPT, ATXN3
negative regulation of hydrogen peroxide-induced neuron death (GO:1903208)	8.34	2	PARK7, PINK1
regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide (GO:1903750)	8.34	2	PARK7, PINK1
cellular response to dopamine (GO:1903351)	7.53	2	PARK2, LRRK2
response to dopamine (GO:1903350)	7.53	2	PARK2, LRRK2
peptidyl-serine phosphorylation (GO:0018105)	4.82	2	LRRK2, PINK1
positive regulation of growth (GO:0045927)	4.25	2	MAPT, PARK2
maintenance of protein location in cell (GO:0032507)	5.27	2	VPS13C, PINK1
regulation of cell activation (GO:0050865)	3.53	2	SNCA, FBXO7
regulation of cellular carbohydrate metabolic process (GO:0010675)	4.81	2	SNCA, PARK2
apoptotic signaling pathway (GO:0097190)	4.12	2	MAPT, HTRA2
polyol metabolic process (GO:0019751)	5.17	2	GBA, SYNJ1
positive regulation of cysteine-type endopeptidase activity (GO:2001056)	4.88	2	SNCA, HTRA2
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	2	PLA2G6, SNCA
negative regulation of JNK cascade (GO:0046329)	6.23	2	PARK2, PINK1
negative regulation of cell cycle process (GO:0010948)	4.37	2	GIGYF2, FBXO7
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide (GO:1903751)	8.34	2	PARK7, PINK1
regulation of ubiquitin-protein transferase activity (GO:0051438)	4.98	2	PARK7, PINK1
response to starvation (GO:0042594)	4.69	2	GBA, LRRK2
regulation of JNK cascade (GO:0046328)	4.65	2	PARK2, PINK1
negative regulation of neurotransmitter transport (GO:0051589)	6.96	2	SNCA, PARK2
regulation of anion transport (GO:0044070)	5.25	2	PLA2G6, SNCA
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	GBA, FBXO7
generation of precursor metabolites and energy (GO:0006091)	4.07	2	SNCA, PINK1
multicellular organismal reproductive process (GO:0048609)	3.35	2	TBP, PLA2G6
macromolecular complex disassembly (GO:0032984)	4.53	2	DNAJC6, SYNJ1
growth (GO:0040007)	3.8	2	MAPT, GIGYF2
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043154)	5.29	2	PARK7, SNCA
negative regulation of cysteine-type endopeptidase activity (GO:2000117)	5.25	2	PARK7, SNCA
protein destabilization (GO:0031648)	6.2	2	SNCA, PARK2
positive regulation of mitochondrial fission (GO:0090141)	7.09	2	PARK2, PINK1
protein depolymerization (GO:0051261)	6.47	2	DNAJC6, SYNJ1
positive regulation of ATP metabolic process (GO:1903580)	6.55	2	PARK7, PINK1
negative regulation of cellular catabolic process (GO:0031330)	5.38	2	ATP13A2, PARK7
regulation of ion homeostasis (GO:2000021)	4.44	2	SNCA, LRRK2
synaptic vesicle endocytosis (GO:0048488)	6.84	2	SYNJ1, SNCA
negative regulation of organelle assembly (GO:1902116)	6.51	2	LRRK2, PINK1
cellular calcium ion homeostasis (GO:0006874)	4.01	2	ATP13A2, PLA2G6
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280)	4.96	2	SNCA, HTRA2
positive regulation of macroautophagy (GO:0016239)	6.07	2	GBA, PINK1
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	2	PARK7, SNCA
negative regulation of mitotic cell cycle (GO:0045930)	4.45	2	GIGYF2, FBXO7
response to retinoic acid (GO:0032526)	5.02	2	SYNJ1, HTRA2
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902177)	7.78	2	PARK7, PARK2
regulation of lipid metabolic process (GO:0019216)	4.08	2	PLA2G6, SNCA
phenol-containing compound biosynthetic process (GO:0046189)	6.26	2	NR4A2, SNCA
apoptotic process (GO:0006915)	3.14	2	MAPT, HTRA2
negative regulation of intracellular protein transport (GO:0090317)	5.23	2	PARK7, LRRK2
positive regulation of protein binding (GO:0032092)	5.42	2	PARK7, LRRK2
positive regulation of cellular amide metabolic process (GO:0034250)	5.0	2	PLA2G6, PINK1
regulation of hormone levels (GO:0010817)	3.56	2	PLA2G6, PARK2
regulation of metal ion transport (GO:0010959)	3.94	2	PLA2G6, SNCA
phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	5.84	2	SYNJ1, FGF20
regulation of stress-activated protein kinase signaling cascade (GO:0070302)	4.44	2	PARK2, PINK1
negative regulation of endopeptidase activity (GO:0010951)	4.26	2	PARK7, SNCA
positive regulation of endopeptidase activity (GO:0010950)	4.78	2	SNCA, HTRA2
positive regulation of response to oxidative stress (GO:1902884)	7.09	2	PARK7, PARK2
cellular protein complex disassembly (GO:0043624)	4.92	2	DNAJC6, SYNJ1
cellular protein complex assembly (GO:0043623)	3.9	2	SYNJ1, PARK2
response to oxygen levels (GO:0070482)	4.02	2	NR4A2, PINK1
regulation of cellular component movement (GO:0051270)	3.08	2	PODXL, MAPT
cytoskeleton organization (GO:0007010)	3.22	2	MAPT, ATXN3
positive regulation of purine nucleotide metabolic process (GO:1900544)	4.85	2	PARK7, PINK1
nervous system development (GO:0007399)	3.53	2	NR4A2, ATXN3
negative regulation of stress-activated MAPK cascade (GO:0032873)	6.02	2	PARK2, PINK1
carbohydrate metabolic process (GO:0005975)	3.26	2	GBA, SYNJ1
regulation of peptide secretion (GO:0002791)	4.38	2	PLA2G6, PARK2
regulation of calcium ion transport (GO:0051924)	4.38	2	PLA2G6, SNCA
microtubule-based movement (GO:0007018)	4.39	2	UCHL1, MAPT
regulation of peptide hormone secretion (GO:0090276)	4.41	2	PLA2G6, PARK2
positive regulation of neuron projection development (GO:0010976)	4.26	2	MAPT, PARK2
positive regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902958)	9.04	2	PARK7, PINK1
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	GIGYF2, FBXO7
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	2	GIGYF2, FBXO7
regulation of hormone secretion (GO:0046883)	4.18	2	PLA2G6, PARK2
regulation of microtubule polymerization or depolymerization (GO:0031110)	5.74	2	MAPT, SNCA
single-organism intracellular transport (GO:1902582)	3.59	2	UCHL1, MAPT
positive regulation of endocytosis (GO:0045807)	4.98	2	SYNJ1, SNCA
positive regulation of cellular component biogenesis (GO:0044089)	3.71	2	MAPT, PINK1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
negative regulation of transferase activity (GO:0051348)	-	3.87	0.003	VPS35, TBP, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of transport (GO:0051049)	-	2.24	0.003	PLA2G6, ATXN2, LRRK2, PARK7, PARK2, DNAJC6, SNCAIP, SYNJ1, MAPT, PINK1, SNCA
behavior (GO:0007610)	-	3.47	0.0	PLA2G6, LRRK2, TBP, NR4A2, MAPT, PARK2, SNCAIP, HTRA2, GIGYF2, SYNJ1, UCHL1, PARK7, SNCA
dopamine transport (GO:0015872)	-	7.33	0.014	PARK7, PARK2, SNCA
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.011	NR4A2, PARK2, PARK7, PINK1, SNCA
neurotransmitter uptake (GO:0001504)	-	7.02	0.001	PARK7, PARK2, SNCA
response to manganese ion (GO:0010042)	-	6.84	0.001	ATP13A2, PARK2, LRRK2
mitochondrion organization (GO:0007005)	-	3.69	0.007	SNCA, PARK7, LRRK2, PINK1, HTRA2
response to inorganic substance (GO:0010035)	-	3.56	0.019	LRRK2, ATP13A2, NR4A2, PARK2, SNCA, PARK7
posttranscriptional regulation of gene expression (GO:0010608)	-	3.64	0.018	EIF4G1, ATXN2, TBP, FBXO7, UCHL1, PARK2, GIGYF2, SNCA, ATXN3, PARK7
regulation of hydrogen peroxide-induced neuron death (GO:1903207)	-	8.34	0.009	PARK7, PINK1
negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	-	6.96	0.045	PARK7, LRRK2
regulation of hydrogen peroxide-induced cell death (GO:1903205)	-	6.78	0.0	PARK7, LRRK2, PINK1
negative regulation of oxidative stress-induced neuron death (GO:1903204)	-	7.65	0.044	PARK7, PINK1
positive regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902958)	-	9.04	0.013	PARK7, PINK1
negative regulation of oxidative stress-induced cell death (GO:1903202)	-	6.23	0.0	PARK7, PARK2, LRRK2, PINK1
regulation of oxidative stress-induced cell death (GO:1903201)	-	5.9	0.0	PARK7, PARK2, LRRK2, PINK1
regulation of mitochondrial electron transport, NADH to ubiquinone (GO:1902956)	-	8.34	0.044	PARK7, PINK1
monoamine transport (GO:0015844)	-	6.64	0.006	PARK7, PARK2, SNCA
negative regulation of transport (GO:0051051)	-	3.6	0.014	LRRK2, ATXN2, PARK7, PARK2, SNCA, MAPT
regulation of protein kinase activity (GO:0045859)	-	3.15	0.01	VPS35, LRRK2, TBP, FBXO7, UCHL1, PARK2, EIF4G1, HTRA2, DNAJC13, GBA, SNCA, PARK7, PINK1
regulation of cellular protein metabolic process (GO:0032268)	-	1.99	0.001	PLA2G6, ATXN2, LRRK2, PARK2, UCHL1, FBXO7, EIF4G1, GIGYF2, GBA, SNCA, PARK7, PINK1
regulation of cellular component organization (GO:0051128)	-	2.01	0.002	PLA2G6, ATXN2, LRRK2, PODXL, MAPT, PARK2, DNAJC6, SNCAIP, SYNJ1, PARK7, PINK1, SNCA
regulation of phosphorylation (GO:0042325)	-	2.5	0.005	PLA2G6, LRRK2, FBXO7, PARK7, PARK2, FGF20, GBA, SNCA, UCHL1, PINK1
negative regulation of phosphorylation (GO:0042326)	-	3.7	0.023	VPS35, LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
cellular response to manganese ion (GO:0071287)	-	7.43	0.0	ATP13A2, PARK2, LRRK2
single-organism behavior (GO:0044708)	-	3.79	0.0	PLA2G6, LRRK2, NR4A2, MAPT, PARK2, SNCAIP, HTRA2, GIGYF2, SYNJ1, UCHL1, PARK7, SNCA
regulation of late endosome to lysosome transport (GO:1902822)	-	8.34	0.026	SNCA, LRRK2
cellular response to stress (GO:0033554)	-	2.51	0.007	PLA2G6, LRRK2, NR4A2, PARK2, HTRA2, GIGYF2, SNCA, ATXN3, PARK7, PINK1
negative regulation of neuron apoptotic process (GO:0043524)	-	4.82	0.002	NR4A2, PARK2, PARK7, PINK1, SNCA
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903377)	-	8.12	0.044	PARK7, PINK1
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway (GO:1903376)	-	7.78	0.045	PARK7, PINK1
regulation of mitochondrion degradation (GO:1903146)	-	5.99	0.0	PARK2, HTRA2, PINK1
negative regulation of kinase activity (GO:0033673)	-	4.22	0.014	GBA, FBXO7, UCHL1, PARK2, PARK7
protein stabilization (GO:0050821)	-	4.86	0.036	TBP, PARK7, UCHL1, SNCA, ATXN2
dopamine uptake involved in synaptic transmission (GO:0051583)	-	8.12	0.0	PARK7, PARK2, SNCA
regulation of neurotransmitter transport (GO:0051588)	-	5.55	0.003	SNCA, PARK2, SNCAIP, LRRK2
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.028	VPS35, LRRK2, DNAJC13, FBXO7, UCHL1, PARK2, EIF4G1, HTRA2, GBA, SNCA
organic substance catabolic process (GO:1901575)	-	2.45	0.0	PLA2G6, GLUD2, LRRK2, ATP13A2, FBXO7, PARK7, PARK2, EIF4G1, HTRA2, GBA, SYNJ1, ATXN3, UCHL1, PINK1
regulation of kinase activity (GO:0043549)	-	3.07	0.011	VPS35, LRRK2, TBP, FBXO7, PARK7, PARK2, EIF4G1, HTRA2, DNAJC13, GBA, SNCA, UCHL1, PINK1
single-organism process (GO:0044699)	-	0.48	0.006	PLA2G6, TBP, SNCAIP, ADH1C, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, GLUD2, ATXN2, PARK2, UCHL1
dopamine uptake (GO:0090494)	-	8.12	0.0	PARK7, PARK2, SNCA
catecholamine uptake (GO:0090493)	-	8.12	0.0	PARK7, PARK2, SNCA
locomotory behavior (GO:0007626)	-	4.53	0.0	LRRK2, PARK7, NR4A2, PARK2, GIGYF2, HTRA2, SNCAIP, SNCA, UCHL1, MAPT
negative regulation of reactive oxygen species metabolic process (GO:2000378)	-	5.99	0.002	TBP, PARK2, HTRA2, PINK1
regulation of release of cytochrome c from mitochondria (GO:0090199)	-	5.94	0.038	PLA2G6, PARK2, PINK1
regulation of catecholamine metabolic process (GO:0042069)	-	6.9	0.002	NR4A2, PARK7, SNCA
regulation of peroxidase activity (GO:2000468)	NEW	9.73	0.003	SNCA, LRRK2
catecholamine metabolic process (GO:0006584)	-	6.02	0.001	NR4A2, PARK2, SNCAIP, SNCA
adult walking behavior (GO:0007628)	-	6.23	0.03	UCHL1, MAPT, HTRA2
negative regulation of protein acetylation (GO:1901984)	-	6.73	0.018	TBP, PARK7, SNCA
regulation of neuron death (GO:1901214)	-	4.19	0.001	LRRK2, NR4A2, PARK2, SNCA, PARK7, PINK1
negative regulation of neuron death (GO:1901215)	-	4.57	0.003	NR4A2, PARK2, PARK7, PINK1, SNCA
negative regulation of protein modification process (GO:0031400)	-	3.4	0.014	VPS35, LRRK2, TBP, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of protein stability (GO:0031647)	-	4.33	0.029	ATXN2, TBP, PARK7, FBXO7, SNCA, UCHL1
regulation of transferase activity (GO:0051338)	-	2.88	0.029	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1, PINK1
positive regulation of signal transduction (GO:0009967)	-	2.5	0.024	EIF4G1, VPS35, LRRK2, PARK7, TBP, MAPT, PARK2, SNCAIP, HTRA2, GIGYF2, FGF20, PLA2G6, SNCA, DNAJC6, PINK1
organic hydroxy compound metabolic process (GO:1901615)	-	3.84	0.003	VPS35, TBP, NR4A2, PARK2, PLA2G6, ADH1C, SYNJ1, SNCAIP, GBA, SNCA, PARK7
negative regulation of phosphorus metabolic process (GO:0010563)	-	3.45	0.001	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1
cellular response to metal ion (GO:0071248)	-	4.81	0.018	LRRK2, ATP13A2, MAPT, PARK2, SNCA, PINK1
cellular response to inorganic substance (GO:0071241)	-	4.67	0.019	LRRK2, ATP13A2, MAPT, PARK2, SNCA, PINK1
regulation of synaptic transmission (GO:0050804)	-	4.09	0.003	PLA2G6, LRRK2, TBP, MAPT, PARK2, SNCAIP, SYNJ1, SNCA, PINK1
cellular catabolic process (GO:0044248)	-	2.62	0.005	EIF4G1, GLUD2, LRRK2, ATP13A2, FBXO7, PARK7, PARK2, HTRA2, GBA, ATXN3, UCHL1, PINK1
cellular response to chemical stimulus (GO:0070887)	-	2.57	0.012	EIF4G1, LRRK2, ATP13A2, NR4A2, PARK2, HTRA2, FGF20, GBA, SNCA, ATXN3, PARK7, PINK1
regulation of catecholamine secretion (GO:0050433)	-	5.99	0.028	SNCA, PARK2, PINK1
vesicle uncoating (GO:0072319)	-	8.34	0.044	DNAJC6, SYNJ1
negative regulation of protein metabolic process (GO:0051248)	-	2.82	0.002	VPS35, ATXN2, LRRK2, TBP, FBXO7, PARK7, PARK2, EIF4G1, GIGYF2, GBA, SNCA, UCHL1, PINK1
regulation of cellular catabolic process (GO:0031329)	-	3.83	0.046	VPS35, ATXN2, LRRK2, TBP, MAPT, PARK2, EIF4G1, HTRA2, GIGYF2, SNCAIP, ATXN3, SNCA, PINK1
regulation of response to oxidative stress (GO:1902882)	-	5.62	0.0	PARK7, PARK2, LRRK2, PINK1, SNCA
catechol-containing compound metabolic process (GO:0009712)	-	6.02	0.001	NR4A2, PARK2, SNCAIP, SNCA
regulation of protein metabolic process (GO:0051246)	-	1.93	0.002	EIF4G1, ATXN2, LRRK2, PARK2, UCHL1, FBXO7, PLA2G6, HTRA2, GIGYF2, GBA, SNCA, PARK7, PINK1
adult locomotory behavior (GO:0008344)	-	5.3	0.0	PARK7, NR4A2, PARK2, GIGYF2, HTRA2, SNCAIP, SNCA, UCHL1, MAPT
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	-	4.74	0.031	EIF4G1, TBP, PARK7, PARK2, SNCA, PINK1
regulation of vesicle-mediated transport (GO:0060627)	-	3.63	0.0	EIF4G1, VPS35, ATXN2, LRRK2, TBP, DNAJC6, PARK2, PLA2G6, SYNJ1, SNCA, PINK1
dopamine metabolic process (GO:0042417)	-	6.51	0.0	NR4A2, PARK2, SNCAIP, SNCA
regulation of neurotransmitter secretion (GO:0046928)	-	5.78	0.001	SNCA, PARK2, SNCAIP, LRRK2
phenol-containing compound metabolic process (GO:0018958)	-	5.33	0.008	NR4A2, PARK2, SNCAIP, SNCA
regulation of localization (GO:0032879)	-	1.94	0.007	PLA2G6, ATXN2, LRRK2, PARK7, PODXL, MAPT, PARK2, SNCAIP, SYNJ1, DNAJC6, PINK1, SNCA
response to oxidative stress (GO:0006979)	-	3.9	0.005	LRRK2, NR4A2, HTRA2, SNCA, PARK7, PINK1
negative regulation of cellular protein metabolic process (GO:0032269)	-	2.88	0.0	VPS35, ATXN2, LRRK2, TBP, PARK2, UCHL1, FBXO7, EIF4G1, GIGYF2, GBA, SNCA, PARK7, PINK1
regulation of cellular response to oxidative stress (GO:1900407)	-	5.72	0.0	PARK2, PARK7, LRRK2, SNCA, PINK1
mitochondrion degradation (GO:0000422)	-	4.63	0.002	PARK2, FBXO7, PINK1
negative regulation of cellular response to oxidative stress (GO:1900408)	-	6.23	0.001	PARK7, PARK2, LRRK2, PINK1
regulation of response to reactive oxygen species (GO:1901031)	-	6.29	0.0	PARK7, LRRK2, PINK1, SNCA
regulation of dopamine metabolic process (GO:0042053)	-	6.9	0.002	NR4A2, PARK7, SNCA
regulation of cellular localization (GO:0060341)	-	3.03	0.005	PLA2G6, LRRK2, PARK7, PARK2, SNCAIP, SYNJ1, MAPT, PINK1, SNCA
response to transition metal nanoparticle (GO:1990267)	-	4.7	0.009	ATP13A2, MAPT, PARK2, SNCA, LRRK2
regulation of mitochondrion organization (GO:0010821)	-	4.34	0.019	PARK2, PLA2G6, LRRK2, HTRA2, PINK1
neuromuscular process (GO:0050905)	-	5.27	0.007	UCHL1, PARK2, GIGYF2, ATXN2
regulation of dopamine secretion (GO:0014059)	-	6.64	0.003	SNCA, PARK2, PINK1
cell death (GO:0008219)	-	3.05	0.0	EIF4G1, ATXN2, LRRK2, TBP, FBXO7, DNAJC6, MAPT, PARK2, VPS35, ATP13A2, GIGYF2, SNCAIP, PLA2G6, GBA, SNCA, UCHL1, ATXN3, SYNJ1, PINK1
catecholamine uptake involved in synaptic transmission (GO:0051934)	-	8.12	0.0	PARK7, PARK2, SNCA
catecholamine transport (GO:0051937)	-	7.09	0.001	PARK7, PARK2, SNCA
regulation of autophagy (GO:0010506)	-	4.21	0.0	LRRK2, TBP, MAPT, PARK2, HTRA2, PINK1
negative regulation of protein kinase activity (GO:0006469)	-	4.29	0.043	VPS35, PARK2, PARK7, FBXO7, GBA, UCHL1, PINK1
negative regulation of phosphate metabolic process (GO:0045936)	-	3.45	0.001	LRRK2, PARK2, PARK7, FBXO7, GBA, SNCA, UCHL1
autophagy (GO:0006914)	-	3.82	0.001	LRRK2, FBXO7, PARK7, PARK2, SNCA, PINK1
regulation of reactive oxygen species metabolic process (GO:2000377)	-	4.71	0.008	PARK7, PARK2, HTRA2, PINK1, SNCA
single-organism cellular process (GO:0044763)	-	0.65	0.001	PLA2G6, TBP, SNCAIP, GBA, SYNJ1, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, GIGYF2, FGF20, ATXN3, VPS35, GLUD2, ATXN2, PARK2, DNAJC6, UCHL1
cellular response to oxidative stress (GO:0034599)	-	4.7	0.003	NR4A2, LRRK2, PARK7, HTRA2, SNCA
regulation of nucleoside metabolic process (GO:0009118)	-	5.82	0.022	VPS35, LRRK2, TBP, MAPT, PARK2, EIF4G1, SNCAIP, SNCA, ATXN3, PARK7, PINK1
catabolic process (GO:0009056)	-	2.38	0.001	EIF4G1, GLUD2, LRRK2, ATP13A2, FBXO7, PARK7, PARK2, PLA2G6, HTRA2, GBA, SYNJ1, ATXN3, UCHL1, PINK1
negative regulation of response to oxidative stress (GO:1902883)	-	6.23	0.001	PARK7, PARK2, LRRK2, PINK1
adult behavior (GO:0030534)	-	4.79	0.0	PARK7, NR4A2, PARK2, GIGYF2, HTRA2, SNCAIP, SNCA, UCHL1, MAPT
regulation of cellular component biogenesis (GO:0044087)	-	3.08	0.024	VPS35, PLA2G6, PARK7, TBP, PODXL, PARK2, EIF4G1, SNCAIP, SNCA, MAPT, PINK1
regulation of synaptic vesicle transport (GO:1902803)	-	6.29	0.0	SYNJ1, PARK2, LRRK2, PINK1
negative regulation of protein phosphorylation (GO:0001933)	-	3.79	0.0	VPS35, LRRK2, FBXO7, PARK7, PARK2, GBA, SNCA, UCHL1, PINK1
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.008	VPS35, LRRK2, PARK7, TBP, FBXO7, DNAJC6, PARK2, EIF4G1, HTRA2, DNAJC13, PLA2G6, GBA, SNCA, UCHL1, MAPT, PINK1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	29	PLA2G6, TBP, CHCHD2, SNCAIP, ADH1C, GBA, SYNJ1, DNAJC13, DNAJC6, MAPT, HTRA2, ATXN8OS, PODXL, PINK1, EIF4G1, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, FGF20, ATXN3, SNCA, VPS35, GLUD2, ATXN2, PARK2, VPS13C, UCHL1
intracellular part (GO:0044424)	0.28	28	PLA2G6, TBP, CHCHD2, SNCAIP, ADH1C, GBA, SYNJ1, DNAJC13, UCHL1, MAPT, HTRA2, ATXN8OS, PODXL, PINK1, EIF4G1, LRRK2, ATP13A2, NR4A2, FBXO7, ATXN3, SNCA, VPS35, GLUD2, ATXN2, PARK2, VPS13C, DNAJC6, PARK7
cytoplasmic part (GO:0044444)	0.82	24	PLA2G6, EIF4G1, SNCAIP, ADH1C, GBA, SYNJ1, UCHL1, DNAJC13, PARK7, MAPT, HTRA2, SNCA, PINK1, CHCHD2, LRRK2, ATP13A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, VPS13C, DNAJC6
cytoplasm (GO:0005737)	1.01	23	PLA2G6, TBP, VPS13C, SYNJ1, DNAJC13, MAPT, ADH1C, ATXN8OS, NR4A2, PINK1, EIF4G1, LRRK2, PARK7, PODXL, FBXO7, ATXN3, SNCA, VPS35, GLUD2, ATXN2, PARK2, SNCAIP, UCHL1
membrane-bounded organelle (GO:0043227)	0.47	23	PLA2G6, TBP, VPS13C, GBA, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, CHCHD2, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, SNCAIP, UCHL1
organelle (GO:0043226)	0.4	23	PLA2G6, TBP, VPS13C, GBA, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, CHCHD2, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, SNCAIP, UCHL1
intracellular organelle (GO:0043229)	0.51	22	PLA2G6, TBP, SNCAIP, GBA, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, CHCHD2, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, UCHL1
intracellular membrane-bounded organelle (GO:0043231)	0.6	22	PLA2G6, TBP, SNCAIP, GBA, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, CHCHD2, LRRK2, PARK7, ATP13A2, NR4A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, UCHL1
membrane (GO:0016020)	0.68	20	EIF4G1, VPS35, LRRK2, ATXN2, ATP13A2, PODXL, MAPT, GIGYF2, HTRA2, DNAJC13, SNCAIP, VPS13C, PLA2G6, GBA, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
intracellular organelle part (GO:0044446)	0.81	18	VPS35, ATXN2, LRRK2, TBP, NR4A2, MAPT, PLA2G6, HTRA2, ATP13A2, VPS13C, DNAJC13, GBA, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
cytosol (GO:0005829)	1.68	18	EIF4G1, LRRK2, FBXO7, DNAJC6, MAPT, PARK2, VPS35, SYNJ1, SNCAIP, ADH1C, VPS13C, PLA2G6, SNCA, UCHL1, ATXN3, PARK7, PINK1, HTRA2
organelle part (GO:0044422)	0.79	18	VPS35, ATXN2, LRRK2, TBP, NR4A2, MAPT, PLA2G6, HTRA2, ATP13A2, VPS13C, DNAJC13, GBA, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
membrane part (GO:0044425)	0.95	15	VPS35, LRRK2, ATP13A2, PODXL, PLA2G6, HTRA2, DNAJC13, SNCAIP, VPS13C, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
macromolecular complex (GO:0032991)	1.35	14	VPS35, ATXN2, LRRK2, PARK7, TBP, FBXO7, MAPT, PARK2, EIF4G1, HTRA2, DNAJC13, SYNJ1, SNCA, PINK1
protein complex (GO:0043234)	1.51	13	VPS35, LRRK2, PARK7, TBP, FBXO7, MAPT, PARK2, EIF4G1, HTRA2, DNAJC13, SNCA, SYNJ1, PINK1
nucleus (GO:0005634)	1.07	11	CHCHD2, TBP, FBXO7, NR4A2, MAPT, PARK2, HTRA2, SNCA, ATXN3, PARK7, PINK1
vesicle (GO:0031982)	1.64	11	VPS35, LRRK2, ATP13A2, PARK7, VPS13C, DNAJC13, SNCAIP, GBA, SNCA, UCHL1, PODXL
organelle membrane (GO:0031090)	1.97	11	VPS35, LRRK2, ATP13A2, HTRA2, DNAJC13, VPS13C, GBA, SYNJ1, ATXN3, SNCA, PINK1
membrane-bounded vesicle (GO:0031988)	1.71	11	VPS35, LRRK2, ATP13A2, PARK7, VPS13C, DNAJC13, SNCAIP, GBA, SNCA, UCHL1, PODXL
neuron part (GO:0097458)	2.64	10	LRRK2, ATP13A2, PARK7, PARK2, SNCAIP, SYNJ1, UCHL1, MAPT, PINK1, SNCA
cell projection (GO:0042995)	2.47	10	LRRK2, ATP13A2, PARK7, MAPT, PARK2, SYNJ1, UCHL1, PODXL, PINK1, SNCA
extracellular region part (GO:0044421)	1.57	10	PLA2G6, LRRK2, DNAJC13, PODXL, VPS35, VPS13C, GBA, SNCA, UCHL1, PARK7
mitochondrion (GO:0005739)	2.42	10	CHCHD2, GLUD2, LRRK2, FBXO7, PARK7, PARK2, PLA2G6, HTRA2, SNCA, PINK1
neuron projection (GO:0043005)	3.12	9	LRRK2, ATP13A2, PARK7, PARK2, SYNJ1, UCHL1, MAPT, PINK1, SNCA
extracellular organelle (GO:0043230)	1.89	8	VPS35, LRRK2, DNAJC13, PODXL, VPS13C, GBA, UCHL1, PARK7
extracellular exosome (GO:0070062)	1.89	8	VPS35, LRRK2, DNAJC13, PODXL, VPS13C, GBA, UCHL1, PARK7
bounding membrane of organelle (GO:0098588)	2.39	8	VPS35, LRRK2, ATP13A2, DNAJC13, VPS13C, GBA, SNCA, PINK1
cell body (GO:0044297)	3.74	8	LRRK2, PARK7, ATP13A2, MAPT, SNCAIP, UCHL1, PODXL, PINK1
nuclear part (GO:0044428)	1.55	8	ATXN2, PARK7, TBP, NR4A2, SNCA, UCHL1, ATXN3, MAPT
extracellular vesicle (GO:1903561)	1.89	8	VPS35, LRRK2, DNAJC13, PODXL, VPS13C, GBA, UCHL1, PARK7
whole membrane (GO:0098805)	2.85	8	VPS35, LRRK2, ATP13A2, DNAJC13, VPS13C, GBA, SNCA, PINK1
intracellular organelle lumen (GO:0070013)	3.05	7	LRRK2, ATP13A2, PARK7, HTRA2, GBA, ATXN3, PINK1
synapse part (GO:0044456)	3.42	7	LRRK2, MAPT, PARK2, SNCAIP, SYNJ1, PARK7, SNCA
mitochondrial part (GO:0044429)	2.92	7	LRRK2, PARK7, HTRA2, VPS13C, SNCA, ATXN3, PINK1
membrane-enclosed lumen (GO:0031974)	3.05	7	LRRK2, ATP13A2, PARK7, HTRA2, GBA, ATXN3, PINK1
organelle lumen (GO:0043233)	3.05	7	LRRK2, ATP13A2, PARK7, HTRA2, GBA, ATXN3, PINK1
endoplasmic reticulum (GO:0005783)	2.56	6	LRRK2, PARK7, PARK2, HTRA2, SNCA, UCHL1
vacuole (GO:0005773)	2.92	6	VPS35, LRRK2, ATP13A2, DNAJC13, GBA, SNCA
integral component of membrane (GO:0016021)	1.14	6	PLA2G6, ATP13A2, PODXL, HTRA2, DNAJC13, PINK1
cell projection part (GO:0044463)	2.97	6	LRRK2, PODXL, SYNJ1, UCHL1, MAPT, SNCA
inclusion body (GO:0016234)	5.55	6	LRRK2, MAPT, PARK2, SNCA, ATXN3, PINK1
axon (GO:0030424)	4.15	6	LRRK2, PARK7, MAPT, SNCA, UCHL1, PINK1
membrane protein complex (GO:0098796)	2.84	6	VPS35, PARK7, HTRA2, SYNJ1, SNCA, PINK1
plasma membrane (GO:0005886)	1.39	6	LRRK2, PARK7, PODXL, SNCA, UCHL1, MAPT
plasma membrane part (GO:0044459)	1.95	6	LRRK2, ATP13A2, PODXL, HTRA2, SNCAIP, SYNJ1
intrinsic component of membrane (GO:0031224)	1.13	6	PLA2G6, ATP13A2, PODXL, HTRA2, DNAJC13, PINK1
catalytic complex (GO:1902494)	2.9	5	PARK2, PARK7, FBXO7, SNCA, PINK1
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	5	SNCA, MAPT, ATXN2, PINK1, HTRA2
mitochondrial membrane (GO:0031966)	3.31	5	VPS13C, LRRK2, ATXN3, HTRA2, PINK1
nucleoplasm (GO:0005654)	1.89	5	TBP, UCHL1, ATXN3, NR4A2, ATXN2
non-membrane-bounded organelle (GO:0043228)	1.76	5	SNCA, MAPT, ATXN2, PINK1, HTRA2
vacuolar part (GO:0044437)	3.26	5	ATP13A2, DNAJC13, VPS35, LRRK2, GBA
presynapse (GO:0098793)	4.97	5	PARK7, PARK2, SYNJ1, LRRK2, SNCA
plasma membrane region (GO:0098590)	2.97	4	PODXL, SNCAIP, SYNJ1, LRRK2
lytic vacuole (GO:0000323)	3.89	4	ATP13A2, GBA, SNCA, LRRK2
Golgi apparatus (GO:0005794)	2.7	4	SNCA, PARK2, LRRK2, ATXN2
chromatin (GO:0000785)	3.99	4	TBP, PARK7, HTRA2, PINK1
transport vesicle (GO:0030133)	4.3	4	ATP13A2, SNCAIP, SNCA, LRRK2
intracellular ribonucleoprotein complex (GO:0030529)	3.19	4	MAPT, LRRK2, ATXN2, SNCA
cytoskeleton (GO:0005856)	2.55	4	MAPT, HTRA2, PINK1, SNCA
extracellular space (GO:0005615)	2.63	4	PODXL, PLA2G6, LRRK2, SNCA
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	4	ATP13A2, SNCAIP, SNCA, LRRK2
cytoplasmic vesicle (GO:0031410)	2.87	4	ATP13A2, SNCAIP, SNCA, LRRK2
vacuolar membrane (GO:0005774)	3.45	4	ATP13A2, DNAJC13, VPS35, GBA
mitochondrial membrane part (GO:0044455)	4.54	4	PARK7, LRRK2, PINK1, SNCA
perinuclear region of cytoplasm (GO:0048471)	3.35	4	SNCA, PARK2, ATXN2, PINK1
neuronal cell body (GO:0043025)	3.9	4	ATP13A2, UCHL1, SNCAIP, LRRK2
organelle outer membrane (GO:0031968)	4.63	4	VPS13C, LRRK2, PINK1, SNCA
intracellular vesicle (GO:0097708)	2.86	4	ATP13A2, SNCAIP, SNCA, LRRK2
vesicle membrane (GO:0012506)	3.63	4	ATP13A2, SYNJ1, SNCA, LRRK2
ribonucleoprotein complex (GO:1990904)	3.19	4	MAPT, LRRK2, ATXN2, SNCA
outer membrane (GO:0019867)	4.6	4	VPS13C, LRRK2, PINK1, SNCA
lysosome (GO:0005764)	3.89	4	ATP13A2, GBA, SNCA, LRRK2
lysosomal membrane (GO:0005765)	4.19	4	ATP13A2, DNAJC13, VPS35, GBA
endosomal part (GO:0044440)	3.73	4	ATP13A2, DNAJC13, VPS35, LRRK2
axon part (GO:0033267)	4.4	4	UCHL1, SYNJ1, LRRK2, SNCA
chromosomal part (GO:0044427)	3.18	4	TBP, PARK7, HTRA2, PINK1
endosome (GO:0005768)	3.25	4	ATP13A2, DNAJC13, VPS35, LRRK2
lytic vacuole membrane (GO:0098852)	4.19	4	ATP13A2, DNAJC13, VPS35, GBA
synaptic vesicle (GO:0008021)	5.19	3	SNCAIP, SNCA, LRRK2
organelle envelope lumen (GO:0031970)	5.41	3	PARK7, HTRA2, PINK1
site of polarized growth (GO:0030427)	4.85	3	MAPT, SNCA, LRRK2
growth cone (GO:0030426)	4.89	3	MAPT, SNCA, LRRK2
endoplasmic reticulum membrane (GO:0005789)	2.95	3	UCHL1, ATXN3, HTRA2
synapse (GO:0045202)	3.58	3	DNAJC6, SNCA, LRRK2
cell junction (GO:0030054)	2.75	3	PODXL, SNCA, LRRK2
exocytic vesicle (GO:0070382)	5.03	3	SNCAIP, SNCA, LRRK2
endoplasmic reticulum part (GO:0044432)	2.73	3	UCHL1, ATXN3, HTRA2
cytoskeletal part (GO:0044430)	2.49	3	PLA2G6, MAPT, SYNJ1
mitochondrial matrix (GO:0005759)	4.03	3	PARK7, ATXN3, LRRK2
mitochondrial intermembrane space (GO:0005758)	5.51	3	PARK7, HTRA2, PINK1
cytoplasmic region (GO:0099568)	4.51	3	UCHL1, SNCA, LRRK2
secretory vesicle (GO:0099503)	4.0	3	SNCAIP, SNCA, LRRK2
membrane region (GO:0098589)	3.95	3	PODXL, PARK7, LRRK2
transferase complex (GO:1990234)	3.32	3	PARK2, FBXO7, PINK1
terminal bouton (GO:0043195)	5.63	3	SYNJ1, SNCA, LRRK2
membrane raft (GO:0045121)	4.18	3	PODXL, PARK7, LRRK2
ubiquitin ligase complex (GO:0000151)	4.23	3	FBXO7, PARK2, PINK1
intracellular (GO:0005622)	2.37	3	UCHL1, LRRK2, FGF20
mitochondrial outer membrane (GO:0005741)	4.76	3	VPS13C, LRRK2, PINK1
membrane microdomain (GO:0098857)	4.17	3	PODXL, PARK7, LRRK2
mitochondrial protein complex (GO:0098798)	4.78	3	PARK7, SNCA, PINK1
ribonucleoprotein granule (GO:0035770)	4.81	2	MAPT, ATXN2
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	SYNJ1, MAPT
dendrite (GO:0030425)	3.92	2	MAPT, LRRK2
oxidoreductase complex (GO:1990204)	5.19	2	PARK7, SNCA
microvillus (GO:0005902)	5.69	2	PODXL, LRRK2
integral component of organelle membrane (GO:0031301)	4.85	2	ATP13A2, PINK1
cytoplasmic ribonucleoprotein granule (GO:0036464)	4.87	2	MAPT, ATXN2
side of membrane (GO:0098552)	4.22	2	HTRA2, LRRK2
supramolecular fiber (GO:0099512)	3.31	2	SYNJ1, MAPT
microtubule (GO:0005874)	3.81	2	SYNJ1, MAPT
endosome membrane (GO:0010008)	3.83	2	ATP13A2, DNAJC13
synaptic membrane (GO:0097060)	4.22	2	SYNJ1, SNCAIP
lysosomal lumen (GO:0043202)	5.32	2	ATP13A2, GBA
intrinsic component of plasma membrane (GO:0031226)	2.53	2	ATP13A2, PODXL
late endosome (GO:0005770)	4.85	2	ATP13A2, VPS35
respiratory chain complex (GO:0098803)	5.47	2	PARK7, SNCA
autophagosome (GO:0005776)	5.64	2	ATP13A2, LRRK2
vacuolar lumen (GO:0005775)	5.06	2	ATP13A2, GBA
inner mitochondrial membrane protein complex (GO:0098800)	5.01	2	PARK7, SNCA
cytoplasmic vesicle part (GO:0044433)	3.41	2	SNCA, LRRK2
Golgi apparatus part (GO:0044431)	3.0	2	LRRK2, ATXN2
postsynapse (GO:0098794)	4.87	2	SNCA, LRRK2
nucleoplasm part (GO:0044451)	3.22	2	TBP, PARK7
Lewy body (GO:0097413)	8.7	2	PARK2, PINK1
neuron projection terminus (GO:0044306)	5.46	2	UCHL1, SNCA
cell projection cytoplasm (GO:0032838)	5.89	2	UCHL1, LRRK2
cytoplasmic side of membrane (GO:0098562)	5.81	2	HTRA2, LRRK2
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	SNCA, LRRK2
organelle subcompartment (GO:0031984)	4.55	2	LRRK2, ATXN2
integral component of plasma membrane (GO:0005887)	2.57	2	ATP13A2, PODXL
respiratory chain complex I (GO:0045271)	5.91	2	PARK7, SNCA
NADH dehydrogenase complex (GO:0030964)	5.91	2	PARK7, SNCA
trans-Golgi network (GO:0005802)	4.92	2	LRRK2, ATXN2
organelle inner membrane (GO:0019866)	3.56	2	LRRK2, PINK1
plasma membrane protein complex (GO:0098797)	3.55	2	SYNJ1, HTRA2
mitochondrial inner membrane (GO:0005743)	3.65	2	LRRK2, PINK1
extracellular region (GO:0005576)	2.18	2	SNCA, FGF20
actin-based cell projection (GO:0098858)	4.83	2	PODXL, LRRK2
mitochondrial respiratory chain complex I (GO:0005747)	5.91	2	PARK7, SNCA
Golgi subcompartment (GO:0098791)	4.63	2	LRRK2, ATXN2
early endosome (GO:0005769)	4.34	2	DNAJC13, VPS35
intrinsic component of organelle membrane (GO:0031300)	4.8	2	ATP13A2, PINK1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
synaptic vesicle (GO:0008021)	-	5.19	0.01	PARK2, SNCA, LRRK2, SNCAIP, ATXN2
neuron projection (GO:0043005)	-	3.12	0.032	LRRK2, MAPT, PARK2, SNCA, UCHL1, PINK1
organelle membrane (GO:0031090)	-	1.97	0.048	VPS35, ATXN2, LRRK2, PODXL, TBP, NR4A2, MAPT, PARK2, EIF4G1, HTRA2, ATP13A2, DNAJC13, GBA, SYNJ1, UCHL1, ATXN3, PARK7, PINK1, SNCA
cytosol (GO:0005829)	-	1.68	0.0	EIF4G1, VPS35, LRRK2, FBXO7, PARK7, MAPT, PARK2, PLA2G6, ADH1C, SYNJ1, HTRA2, SNCA, UCHL1, ATXN3, DNAJC6, PINK1
trans-Golgi network (GO:0005802)	-	4.92	0.016	VPS35, LRRK2, MAPT, ATXN2, SNCA
cell body (GO:0044297)	-	3.74	0.016	VPS35, LRRK2, TBP, PODXL, PARK2, SNCAIP, SNCA, UCHL1, MAPT, PINK1
inclusion body (GO:0016234)	-	5.55	0.0	TBP, SNCA, PARK2, LRRK2, PINK1
axon (GO:0030424)	-	4.15	0.001	LRRK2, MAPT, PARK2, SNCAIP, SNCA, UCHL1, PINK1
cytoplasmic part (GO:0044444)	-	0.82	0.002	PLA2G6, CHCHD2, SNCAIP, ADH1C, GBA, SYNJ1, UCHL1, DNAJC13, PARK7, HTRA2, SNCA, PINK1, EIF4G1, LRRK2, ATP13A2, FBXO7, ATXN3, VPS35, GLUD2, ATXN2, PARK2, DNAJC6, MAPT
mitochondrion (GO:0005739)	-	2.42	0.004	CHCHD2, GLUD2, LRRK2, PARK7, TBP, FBXO7, NR4A2, PARK2, EIF4G1, HTRA2, SNCAIP, PLA2G6, SNCA, UCHL1, PINK1
Lewy body (GO:0097413)	-	8.7	0.001	PARK2, PINK1
neuronal cell body (GO:0043025)	-	3.9	0.018	VPS35, LRRK2, TBP, MAPT, PARK2, SNCAIP, SNCA, UCHL1
vesicle (GO:0031982)	-	1.64	0.01	TBP, SNCAIP, GBA, SYNJ1, UCHL1, DNAJC13, MAPT, HTRA2, SNCA, PODXL, PINK1, EIF4G1, LRRK2, PARK7, NR4A2, GIGYF2, ATXN3, VPS35, ATXN2, PARK2, VPS13C, DNAJC6