Disease table of ACUTE PROMYELOCYTIC LEUKEMIA OMIM ID: 612376

Gene-disease associations table

GeneAssociated with ACUTE PROMYELOCYTIC LEUKEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
RARAOMIMHGNC link17q21.21612376
NUMA1OMIMHGNC link11q13.41612376

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
RARAYES26RARB, PLAU, MACROD1, SCD, RPTOR, ANXA8, ICAM1, NR1I3, MUC5AC, KLF5, THBD, GNRH2, MAOB, CRABP1, FGFBP1, CDKN1A, SFTPB, CYP1A1, ABCC3, CXCR5, ETS1, CRH, HSD17B2, CCNA1, PRKCA, HNF4A0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
RARAYES6SP1, CREBBP, JUN, CRABP2, ESR1, KLF40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RARANUMA1No6RUVBL1, NCOA6, NPM1, EZH2, SUZ12, SUMO2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
RARANUMA1No-3UBC, HDAC3, NCOR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Mitotic G2-G2/M phases (R-HSA-453274) NEW6.040.035NUMA1, RARA
G2/M Transition (R-HSA-69275) NEW6.060.031NUMA1, RARA
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182NUMA1, RARA
protein binding (GO:0005515) 0.462NUMA1, RARA
cytoskeletal protein binding (GO:0008092) 3.022NUMA1, RARA
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single organism reproductive process (GO:0044702) 2.732NUMA1, RARA
cellular developmental process (GO:0048869) 1.822NUMA1, RARA
cell differentiation (GO:0030154) 2.142NUMA1, RARA
reproductive process (GO:0022414) 2.552NUMA1, RARA
single-organism cellular process (GO:0044763) 0.652NUMA1, RARA
single-organism process (GO:0044699) 0.482NUMA1, RARA
cellular process (GO:0009987) 0.262NUMA1, RARA
establishment of localization (GO:0051234) 1.482NUMA1, RARA
localization (GO:0051179) 1.42NUMA1, RARA
single-organism localization (GO:1902578) 2.092NUMA1, RARA

NET-GE enrichment

Term New enriched termICP valueGenes
lung epithelial cell differentiation (GO:0060487) NEW6.510.012NUMA1, RARA
lung cell differentiation (GO:0060479) NEW6.470.012NUMA1, RARA
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
dendrite (GO:0030425) 3.922NUMA1, RARA
intracellular organelle (GO:0043229) 0.512NUMA1, RARA
non-membrane-bounded organelle (GO:0043228) 1.762NUMA1, RARA
membrane-bounded organelle (GO:0043227) 0.472NUMA1, RARA
organelle (GO:0043226) 0.42NUMA1, RARA
cytoskeleton (GO:0005856) 2.552NUMA1, RARA
nucleus (GO:0005634) 1.072NUMA1, RARA
nucleoplasm (GO:0005654) 1.892NUMA1, RARA
neuron part (GO:0097458) 2.642NUMA1, RARA
neuron projection (GO:0043005) 3.122NUMA1, RARA
neuronal cell body (GO:0043025) 3.92NUMA1, RARA
cytoplasm (GO:0005737) 1.012NUMA1, RARA
cell body (GO:0044297) 3.742NUMA1, RARA
cell projection (GO:0042995) 2.472NUMA1, RARA
intracellular membrane-bounded organelle (GO:0043231) 0.62NUMA1, RARA
intracellular non-membrane-bounded organelle (GO:0043232) 1.762NUMA1, RARA
cell part (GO:0044464) 0.112NUMA1, RARA
intracellular organelle part (GO:0044446) 0.812NUMA1, RARA
cytoplasmic part (GO:0044444) 0.822NUMA1, RARA
nuclear part (GO:0044428) 1.552NUMA1, RARA
intracellular part (GO:0044424) 0.282NUMA1, RARA
organelle part (GO:0044422) 0.792NUMA1, RARA

NET-GE enrichment

Term New enriched termICP valueGenes
neuronal cell body (GO:0043025) -3.90.008NUMA1, RARA
cell body (GO:0044297) -3.740.012NUMA1, RARA
dendrite (GO:0030425) -3.920.008NUMA1, RARA
neuron projection (GO:0043005) -3.120.04NUMA1, RARA