Disease table of FAMILIAL COLD AUTOINFLAMMATORY SYNDROME OMIM ID: PS120100

Gene-disease associations table

GeneAssociated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NLRC4ClinVar, OMIM, HUMSAVARHGNC link2p22.32616050, PS120100
PLCG2OMIMHGNC link16q23.32614878, PS120100
NLRP3ClinVar, OMIM, HUMSAVARHGNC link1q443191900, PS120100, 607115
NLRP12ClinVar, OMIMHGNC link19q13.421PS120100

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NLRC4YES1TP530
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NLRC4NLRP3Yes1NLRC4
NLRP3NLRP12No2HSP90AA1, FAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
NOD-like receptor signaling pathwayhsa046216.882NLRC4, NLRP3

NET-GE enrichment

Term New enriched termICP valueGenes
Infectious diseases: BacterialNEW3.760.02PLCG2, NLRC4, NLRP3
NOD-like receptor signaling pathway (hsa04621) -6.880.022NLRC4, NLRP3
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Innate Immune SystemR-HSA-1682493.173PLCG2, NLRC4, NLRP3
Immune SystemR-HSA-1682562.373PLCG2, NLRC4, NLRP3
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.312NLRC4, NLRP3
InflammasomesR-HSA-6223128.892NLRC4, NLRP3

NET-GE enrichment

Term New enriched termICP valueGenes
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (R-HSA-168643) -7.310.008NLRC4, NLRP3
The NLRP3 inflammasome (R-HSA-844456) NEW9.40.001NLRC4, NLRP3
Innate Immune System (R-HSA-168249) -3.170.038PLCG2, NLRC4, NLRP3
Inflammasomes (R-HSA-622312) -8.890.001NLRC4, NLRP3
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184PLCG2, NLRC4, NLRP12, NLRP3
protein binding (GO:0005515) 0.464PLCG2, NLRC4, NLRP12, NLRP3
adenyl nucleotide binding (GO:0030554) 2.43NLRC4, NLRP12, NLRP3
purine ribonucleoside triphosphate binding (GO:0035639) 2.223NLRC4, NLRP12, NLRP3
ATP binding (GO:0005524) 2.433NLRC4, NLRP12, NLRP3
ribonucleotide binding (GO:0032553) 2.193NLRC4, NLRP12, NLRP3
nucleotide binding (GO:0000166) 1.963NLRC4, NLRP12, NLRP3
small molecule binding (GO:0036094) 1.893NLRC4, NLRP12, NLRP3
carbohydrate derivative binding (GO:0097367) 2.033NLRC4, NLRP12, NLRP3
purine ribonucleoside binding (GO:0032550) 2.223NLRC4, NLRP12, NLRP3
adenyl ribonucleotide binding (GO:0032559) 2.413NLRC4, NLRP12, NLRP3
purine nucleoside binding (GO:0001883) 2.223NLRC4, NLRP12, NLRP3
ribonucleoside binding (GO:0032549) 2.223NLRC4, NLRP12, NLRP3
purine ribonucleotide binding (GO:0032555) 2.23NLRC4, NLRP12, NLRP3
purine nucleotide binding (GO:0017076) 2.193NLRC4, NLRP12, NLRP3
organic cyclic compound binding (GO:0097159) 1.053NLRC4, NLRP12, NLRP3
heterocyclic compound binding (GO:1901363) 1.063NLRC4, NLRP12, NLRP3
nucleoside phosphate binding (GO:1901265) 1.963NLRC4, NLRP12, NLRP3
nucleoside binding (GO:0001882) 2.213NLRC4, NLRP12, NLRP3
catalytic activity (GO:0003824) 1.052PLCG2, NLRC4
enzyme regulator activity (GO:0030234) 2.852NLRC4, NLRP12
molecular function regulator (GO:0098772) 2.512NLRC4, NLRP12
peptidase regulator activity (GO:0061134) 4.372NLRC4, NLRP12

NET-GE enrichment

Term New enriched termICP valueGenes
cysteine-type endopeptidase regulator activity involved in apoptotic process (GO:0043028) NEW6.020.012NLRC4, NLRP12
peptidoglycan binding (GO:0042834) NEW7.250.0NLRC4, NLRP3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
positive regulation of metabolic process (GO:0009893) 1.744PLCG2, NLRC4, NLRP12, NLRP3
regulation of metabolic process (GO:0019222) 1.024PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of cellular metabolic process (GO:0031325) 1.814PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of response to stimulus (GO:0048584) 2.184PLCG2, NLRC4, NLRP12, NLRP3
regulation of response to stimulus (GO:0048583) 1.544PLCG2, NLRC4, NLRP12, NLRP3
regulation of cell death (GO:0010941) 2.434PLCG2, NLRC4, NLRP12, NLRP3
regulation of biological process (GO:0050789) 0.454PLCG2, NLRC4, NLRP12, NLRP3
single-organism process (GO:0044699) 0.484PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of macromolecule metabolic process (GO:0010604) 1.814PLCG2, NLRC4, NLRP12, NLRP3
regulation of programmed cell death (GO:0043067) 2.494PLCG2, NLRC4, NLRP12, NLRP3
biological regulation (GO:0065007) 0.394PLCG2, NLRC4, NLRP12, NLRP3
regulation of defense response (GO:0031347) 3.114PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of molecular function (GO:0044093) 2.234PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of biological process (GO:0048518) 1.24PLCG2, NLRC4, NLRP12, NLRP3
negative regulation of biological process (GO:0048519) 1.334PLCG2, NLRC4, NLRP12, NLRP3
regulation of molecular function (GO:0065009) 1.784PLCG2, NLRC4, NLRP12, NLRP3
regulation of gene expression (GO:0010468) 1.374PLCG2, NLRC4, NLRP12, NLRP3
regulation of macromolecule metabolic process (GO:0060255) 1.084PLCG2, NLRC4, NLRP12, NLRP3
regulation of cellular metabolic process (GO:0031323) 1.074PLCG2, NLRC4, NLRP12, NLRP3
cellular process (GO:0009987) 0.264PLCG2, NLRC4, NLRP12, NLRP3
regulation of cellular process (GO:0050794) 0.54PLCG2, NLRC4, NLRP12, NLRP3
single-organism cellular process (GO:0044763) 0.654PLCG2, NLRC4, NLRP12, NLRP3
response to stimulus (GO:0050896) 1.224PLCG2, NLRC4, NLRP12, NLRP3
immune system process (GO:0002376) 2.294PLCG2, NLRC4, NLRP12, NLRP3
regulation of response to stress (GO:0080134) 2.534PLCG2, NLRC4, NLRP12, NLRP3
negative regulation of cellular process (GO:0048523) 1.414PLCG2, NLRC4, NLRP12, NLRP3
positive regulation of cellular process (GO:0048522) 1.34PLCG2, NLRC4, NLRP12, NLRP3
regulation of primary metabolic process (GO:0080090) 1.083NLRC4, NLRP12, NLRP3
regulation of protein metabolic process (GO:0051246) 1.933NLRC4, NLRP12, NLRP3
regulation of transport (GO:0051049) 2.243PLCG2, NLRP12, NLRP3
regulation of signaling (GO:0023051) 1.723NLRC4, NLRP12, NLRP3
positive regulation of cysteine-type endopeptidase activity (GO:2001056) 4.883NLRC4, NLRP12, NLRP3
positive regulation of defense response (GO:0031349) 3.833PLCG2, NLRC4, NLRP12
signal transduction (GO:0007165) 1.283PLCG2, NLRP12, NLRP3
response to chemical (GO:0042221) 1.983PLCG2, NLRP12, NLRP3
positive regulation of cell death (GO:0010942) 3.323NLRC4, NLRP12, NLRP3
regulation of localization (GO:0032879) 1.943PLCG2, NLRP12, NLRP3
regulation of cell communication (GO:0010646) 1.733NLRC4, NLRP12, NLRP3
regulation of apoptotic process (GO:0042981) 2.53NLRC4, NLRP12, NLRP3
positive regulation of catalytic activity (GO:0043085) 2.43NLRC4, NLRP12, NLRP3
establishment of localization (GO:0051234) 1.483PLCG2, NLRC4, NLRP3
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) 4.963NLRC4, NLRP12, NLRP3
positive regulation of hydrolase activity (GO:0051345) 2.913NLRC4, NLRP12, NLRP3
regulation of transcription, DNA-templated (GO:0006355) 1.563NLRC4, NLRP12, NLRP3
regulation of cysteine-type endopeptidase activity (GO:2000116) 4.373NLRC4, NLRP12, NLRP3
positive regulation of multicellular organismal process (GO:0051240) 2.493PLCG2, NLRP12, NLRP3
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) 5.263NLRC4, NLRP12, NLRP3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463NLRC4, NLRP12, NLRP3
positive regulation of protein metabolic process (GO:0051247) 2.433NLRC4, NLRP12, NLRP3
regulation of cytokine production (GO:0001817) 3.43PLCG2, NLRP12, NLRP3
positive regulation of apoptotic process (GO:0043065) 3.383NLRC4, NLRP12, NLRP3
regulation of endopeptidase activity (GO:0052548) 3.83NLRC4, NLRP12, NLRP3
positive regulation of immune system process (GO:0002684) 2.963PLCG2, NLRC4, NLRP3
regulation of cellular protein metabolic process (GO:0032268) 1.993NLRC4, NLRP12, NLRP3
regulation of immune system process (GO:0002682) 2.53PLCG2, NLRC4, NLRP3
negative regulation of molecular function (GO:0044092) 2.743NLRC4, NLRP12, NLRP3
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) 4.433NLRC4, NLRP12, NLRP3
positive regulation of cellular protein metabolic process (GO:0032270) 2.493NLRC4, NLRP12, NLRP3
positive regulation of programmed cell death (GO:0043068) 3.383NLRC4, NLRP12, NLRP3
transport (GO:0006810) 1.513PLCG2, NLRC4, NLRP3
positive regulation of transport (GO:0051050) 2.93PLCG2, NLRP12, NLRP3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433NLRC4, NLRP12, NLRP3
regulation of catalytic activity (GO:0050790) 1.973NLRC4, NLRP12, NLRP3
regulation of biosynthetic process (GO:0009889) 1.373NLRC4, NLRP12, NLRP3
regulation of nucleic acid-templated transcription (GO:1903506) 1.553NLRC4, NLRP12, NLRP3
regulation of cellular biosynthetic process (GO:0031326) 1.383NLRC4, NLRP12, NLRP3
organic substance metabolic process (GO:0071704) 0.633PLCG2, NLRC4, NLRP3
single-organism transport (GO:0044765) 2.183PLCG2, NLRC4, NLRP3
regulation of immune response (GO:0050776) 2.983PLCG2, NLRC4, NLRP3
regulation of proteolysis (GO:0030162) 3.23NLRC4, NLRP12, NLRP3
regulation of nitrogen compound metabolic process (GO:0051171) 1.363NLRC4, NLRP12, NLRP3
regulation of multicellular organismal process (GO:0051239) 1.873PLCG2, NLRP12, NLRP3
regulation of RNA biosynthetic process (GO:2001141) 1.553NLRC4, NLRP12, NLRP3
localization (GO:0051179) 1.43PLCG2, NLRC4, NLRP3
positive regulation of endopeptidase activity (GO:0010950) 4.783NLRC4, NLRP12, NLRP3
positive regulation of peptidase activity (GO:0010952) 4.73NLRC4, NLRP12, NLRP3
metabolic process (GO:0008152) 0.583PLCG2, NLRC4, NLRP3
response to organic substance (GO:0010033) 2.23PLCG2, NLRP12, NLRP3
single-organism localization (GO:1902578) 2.093PLCG2, NLRC4, NLRP3
regulation of hydrolase activity (GO:0051336) 2.533NLRC4, NLRP12, NLRP3
primary metabolic process (GO:0044238) 0.693PLCG2, NLRC4, NLRP3
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.833NLRC4, NLRP12, NLRP3
response to biotic stimulus (GO:0009607) 3.093PLCG2, NLRC4, NLRP3
response to external biotic stimulus (GO:0043207) 3.133PLCG2, NLRC4, NLRP3
response to external stimulus (GO:0009605) 2.553PLCG2, NLRC4, NLRP3
regulation of RNA metabolic process (GO:0051252) 1.523NLRC4, NLRP12, NLRP3
positive regulation of immune response (GO:0050778) 3.43PLCG2, NLRC4, NLRP3
cellular metabolic process (GO:0044237) 0.693PLCG2, NLRC4, NLRP3
regulation of signal transduction (GO:0009966) 1.843NLRC4, NLRP12, NLRP3
regulation of macromolecule biosynthetic process (GO:0010556) 1.433NLRC4, NLRP12, NLRP3
regulation of peptidase activity (GO:0052547) 3.753NLRC4, NLRP12, NLRP3
positive regulation of proteolysis (GO:0045862) 3.863NLRC4, NLRP12, NLRP3
positive regulation of cytokine production (GO:0001819) 3.823PLCG2, NLRP12, NLRP3
regulation of intracellular protein transport (GO:0033157) 3.82NLRP12, NLRP3
detection of biotic stimulus (GO:0009595) 6.552NLRC4, NLRP3
protein localization (GO:0008104) 2.362NLRC4, NLRP3
regulation of secretion (GO:0051046) 3.22NLRP12, NLRP3
positive regulation of secretion (GO:0051047) 3.852NLRP12, NLRP3
negative regulation of secretion (GO:0051048) 4.442NLRP12, NLRP3
negative regulation of response to stimulus (GO:0048585) 2.522NLRP12, NLRP3
negative regulation of defense response (GO:0031348) 4.752NLRP12, NLRP3
cellular component organization or biogenesis (GO:0071840) 1.222NLRC4, NLRP3
cellular response to stimulus (GO:0051716) 1.972NLRP12, NLRP3
negative regulation of macromolecule metabolic process (GO:0010605) 2.012NLRC4, NLRP12
negative regulation of signal transduction (GO:0009968) 2.752NLRP12, NLRP3
regulation of inflammatory response (GO:0050727) 4.032NLRP12, NLRP3
negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124) 5.782NLRP12, NLRP3
macromolecule localization (GO:0033036) 2.342NLRC4, NLRP3
regulation of intracellular transport (GO:0032386) 3.582NLRP12, NLRP3
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272NLRP12, NLRP3
regulation of interleukin-1 production (GO:0032652) 5.692NLRP12, NLRP3
negative regulation of transport (GO:0051051) 3.62NLRP12, NLRP3
regulation of interleukin-1 beta production (GO:0032651) 5.882NLRP12, NLRP3
negative regulation of cell death (GO:0060548) 2.952PLCG2, NLRC4
negative regulation of cellular protein metabolic process (GO:0032269) 2.882NLRC4, NLRP12
establishment of protein localization (GO:0045184) 2.532NLRC4, NLRP3
response to other organism (GO:0051707) 3.482NLRC4, NLRP3
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433) 4.822NLRP12, NLRP3
regulation of transcription factor import into nucleus (GO:0042990) 5.162NLRP12, NLRP3
multi-organism process (GO:0051704) 2.652NLRC4, NLRP3
regulation of biological quality (GO:0065008) 1.682PLCG2, NLRP12
negative regulation of signaling (GO:0023057) 2.652NLRP12, NLRP3
regulation of protein import (GO:1904589) 4.522NLRP12, NLRP3
positive regulation of interleukin-1 beta production (GO:0032731) 6.332NLRP12, NLRP3
positive regulation of interleukin-1 production (GO:0032732) 6.152NLRP12, NLRP3
cellular component assembly (GO:0022607) 2.142NLRC4, NLRP3
negative regulation of metabolic process (GO:0009892) 1.932NLRC4, NLRP12
cellular response to chemical stimulus (GO:0070887) 2.572NLRP12, NLRP3
positive regulation of biosynthetic process (GO:0009891) 2.292NLRP12, NLRP3
secretion by cell (GO:0032940) 3.592NLRC4, NLRP3
positive regulation of protein transport (GO:0051222) 3.612NLRP12, NLRP3
regulation of protein transport (GO:0051223) 3.122NLRP12, NLRP3
negative regulation of protein transport (GO:0051224) 4.442NLRP12, NLRP3
organic substance biosynthetic process (GO:1901576) 1.342PLCG2, NLRP3
regulation of protein secretion (GO:0050708) 3.772NLRP12, NLRP3
negative regulation of protein secretion (GO:0050709) 5.062NLRP12, NLRP3
cellular macromolecule metabolic process (GO:0044260) 0.932NLRC4, NLRP3
regulation of interleukin-1 secretion (GO:0050704) 6.262NLRP12, NLRP3
regulation of interleukin-1 beta secretion (GO:0050706) 6.362NLRP12, NLRP3
regulation of cytokine secretion (GO:0050707) 4.742NLRP12, NLRP3
interleukin-1 secretion (GO:0050701) 7.432NLRC4, NLRP3
cellular component organization (GO:0016043) 1.242NLRC4, NLRP3
macromolecular complex assembly (GO:0065003) 2.552NLRC4, NLRP3
negative regulation of cellular protein localization (GO:1903828) 4.822NLRP12, NLRP3
regulation of establishment of protein localization (GO:0070201) 3.022NLRP12, NLRP3
apoptotic process (GO:0006915) 3.142NLRC4, NLRP3
protein secretion (GO:0009306) 4.972NLRC4, NLRP3
negative regulation of inflammatory response (GO:0050728) 5.112NLRP12, NLRP3
defense response (GO:0006952) 2.782NLRC4, NLRP3
programmed cell death (GO:0012501) 3.12NLRC4, NLRP3
response to stress (GO:0006950) 1.82NLRC4, NLRP3
inflammatory response (GO:0006954) 3.642NLRC4, NLRP3
immune response (GO:0006955) 2.862NLRC4, NLRP3
negative regulation of intracellular signal transduction (GO:1902532) 3.632NLRP12, NLRP3
regulation of protein import into nucleus (GO:0042306) 4.542NLRP12, NLRP3
regulation of intracellular signal transduction (GO:1902531) 2.312NLRP12, NLRP3
regulation of protein localization to nucleus (GO:1900180) 4.342NLRP12, NLRP3
secretion (GO:0046903) 3.382NLRC4, NLRP3
negative regulation of cytokine secretion (GO:0050710) 5.922NLRP12, NLRP3
detection of stimulus (GO:0051606) 3.222NLRC4, NLRP3
positive regulation of interleukin-1 secretion (GO:0050716) 6.552NLRP12, NLRP3
positive regulation of cytokine secretion (GO:0050715) 5.162NLRP12, NLRP3
positive regulation of protein secretion (GO:0050714) 4.392NLRP12, NLRP3
positive regulation of interleukin-1 beta secretion (GO:0050718) 6.592NLRP12, NLRP3
negative regulation of NF-kappaB transcription factor activity (GO:0032088) 5.512NLRP12, NLRP3
activation of innate immune response (GO:0002218) 4.412PLCG2, NLRC4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392NLRP12, NLRP3
regulation of nucleocytoplasmic transport (GO:0046822) 4.332NLRP12, NLRP3
negative regulation of response to external stimulus (GO:0032102) 4.182NLRP12, NLRP3
regulation of response to external stimulus (GO:0032101) 3.062NLRP12, NLRP3
regulation of cellular protein localization (GO:1903827) 3.432NLRP12, NLRP3
cellular biosynthetic process (GO:0044249) 1.372PLCG2, NLRP3
negative regulation of secretion by cell (GO:1903531) 4.552NLRP12, NLRP3
regulation of secretion by cell (GO:1903530) 3.282NLRP12, NLRP3
regulation of protein targeting (GO:1903533) 4.02NLRP12, NLRP3
positive regulation of secretion by cell (GO:1903532) 3.932NLRP12, NLRP3
negative regulation of establishment of protein localization (GO:1904950) 4.392NLRP12, NLRP3
positive regulation of establishment of protein localization (GO:1904951) 3.492NLRP12, NLRP3
regulation of protein localization (GO:0032880) 2.882NLRP12, NLRP3
negative regulation of protein metabolic process (GO:0051248) 2.822NLRC4, NLRP12
negative regulation of multicellular organismal process (GO:0051241) 2.842NLRP12, NLRP3
negative regulation of interleukin-1 secretion (GO:0050711) 7.532NLRP12, NLRP3
defense response to other organism (GO:0098542) 3.752NLRC4, NLRP3
protein oligomerization (GO:0051259) 3.712NLRC4, NLRP3
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852NLRC4, NLRP3
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292NLRC4, NLRP3
macromolecule metabolic process (GO:0043170) 0.832NLRC4, NLRP3
response to molecule of bacterial origin (GO:0002237) 3.992PLCG2, NLRP3
negative regulation of cytokine production (GO:0001818) 4.42NLRP12, NLRP3
regulation of cellular localization (GO:0060341) 3.032NLRP12, NLRP3
macromolecular complex subunit organization (GO:0043933) 2.142NLRC4, NLRP3
negative regulation of cellular metabolic process (GO:0031324) 2.012NLRC4, NLRP12
cell death (GO:0008219) 3.052NLRC4, NLRP3
response to lipopolysaccharide (GO:0032496) 4.032PLCG2, NLRP3
cytokine secretion (GO:0050663) 6.072NLRC4, NLRP3
protein complex subunit organization (GO:0071822) 2.62NLRC4, NLRP3
response to lipid (GO:0033993) 3.112PLCG2, NLRP3
negative regulation of interleukin-1 production (GO:0032692) 6.842NLRP12, NLRP3
cellular response to organic substance (GO:0071310) 2.782NLRP12, NLRP3
organic substance transport (GO:0071702) 2.152NLRC4, NLRP3
negative regulation of programmed cell death (GO:0043069) 3.022PLCG2, NLRC4
positive regulation of innate immune response (GO:0045089) 4.222PLCG2, NLRC4
regulation of innate immune response (GO:0045088) 3.862PLCG2, NLRC4
innate immune response (GO:0045087) 3.552NLRC4, NLRP3
protein complex assembly (GO:0006461) 2.782NLRC4, NLRP3
biosynthetic process (GO:0009058) 1.322PLCG2, NLRP3
response to oxygen-containing compound (GO:1901700) 2.572PLCG2, NLRP3
regulation of NF-kappaB import into nucleus (GO:0042345) 5.862NLRP12, NLRP3
negative regulation of cell communication (GO:0010648) 2.662NLRP12, NLRP3
activation of immune response (GO:0002253) 3.672PLCG2, NLRC4
immune effector process (GO:0002252) 3.582PLCG2, NLRP3
protein transport (GO:0015031) 2.622NLRC4, NLRP3

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of cytokine secretion (GO:0050715) -5.160.034NLRC4, NLRP12, NLRP3
detection of biotic stimulus (GO:0009595) -6.550.005NLRC4, NLRP3
regulation of cytokine secretion (GO:0050707) -4.740.014NLRC4, NLRP12, NLRP3
positive regulation of cysteine-type endopeptidase activity (GO:2001056) -4.880.0NLRC4, NLRP12, NLRP3
zymogen activation (GO:0031638) NEW6.330.004NLRC4, NLRP12, NLRP3
negative regulation of defense response (GO:0031348) -4.750.014NLRC4, NLRP12, NLRP3
regulation of cell death (GO:0010941) -2.430.012PLCG2, NLRC4, NLRP12, NLRP3
regulation of defense response (GO:0031347) -3.110.035NLRC4, NLRP12, NLRP3
cytokine secretion (GO:0050663) -6.070.006NLRC4, NLRP3
regulation of NF-kappaB import into nucleus (GO:0042345) -5.860.011NLRP12, NLRP3
activation of cysteine-type endopeptidase activity (GO:0097202) NEW7.240.0NLRC4, NLRP12, NLRP3
positive regulation of peptidase activity (GO:0010952) -4.70.001NLRC4, NLRP12, NLRP3
negative regulation of protein secretion (GO:0050709) -5.060.015NLRP12, NLRP3
positive regulation of MHC class I biosynthetic process (GO:0045345) NEW8.120.001NLRP12, NLRP3
regulation of interleukin-1 secretion (GO:0050704) -6.260.0NLRC4, NLRP12, NLRP3
regulation of interleukin-1 beta secretion (GO:0050706) -6.360.003NLRC4, NLRP12, NLRP3
activation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0006919) -5.260.0NLRC4, NLRP12, NLRP3
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872) NEW6.40.044NLRC4, NLRP3
negative regulation of interleukin-1 production (GO:0032692) -6.840.0NLRC4, NLRP12, NLRP3
regulation of endopeptidase activity (GO:0052548) -3.80.012NLRC4, NLRP12, NLRP3
regulation of programmed cell death (GO:0043067) -2.490.01PLCG2, NLRC4, NLRP12, NLRP3
negative regulation of interleukin-1 beta production (GO:0032691) NEW7.090.004NLRC4, NLRP3
positive regulation of molecular function (GO:0044093) -2.230.025PLCG2, NLRC4, NLRP12, NLRP3
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) -4.430.002NLRC4, NLRP12, NLRP3
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043280) -4.960.0NLRC4, NLRP12, NLRP3
negative regulation of response to wounding (GO:1903035) NEW5.540.007NLRC4, NLRP12, NLRP3
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) -4.270.042NLRC4, NLRP12, NLRP3
interleukin-1 secretion (GO:0050701) -7.430.001NLRC4, NLRP3
regulation of interleukin-1 production (GO:0032652) -5.690.0NLRC4, NLRP12, NLRP3
regulation of MHC class I biosynthetic process (GO:0045343) NEW7.780.015NLRP12, NLRP3
regulation of interleukin-1 beta production (GO:0032651) -5.880.01NLRC4, NLRP12, NLRP3
interleukin-1 production (GO:0032612) NEW8.120.0NLRC4, NLRP3
interleukin-1 beta production (GO:0032611) NEW8.120.0NLRC4, NLRP3
negative regulation of inflammatory response (GO:0050728) -5.110.004NLRC4, NLRP12, NLRP3
protein secretion (GO:0009306) -4.970.032NLRC4, NLRP3
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) -3.830.01NLRC4, NLRP12, NLRP3
regulation of proteolysis (GO:0030162) -3.20.035NLRC4, NLRP12, NLRP3
protein processing (GO:0016485) NEW4.620.045NLRC4, NLRP12, NLRP3
positive regulation of endopeptidase activity (GO:0010950) -4.780.008NLRC4, NLRP12, NLRP3
negative regulation of type I interferon-mediated signaling pathway (GO:0060339) NEW8.120.0NLRC4, NLRP3
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433) -4.820.018NLRC4, NLRP12, NLRP3
regulation of transcription factor import into nucleus (GO:0042990) -5.160.038NLRP12, NLRP3
negative regulation of interleukin-1 secretion (GO:0050711) -7.530.0NLRP12, NLRP3
negative regulation of cytokine secretion (GO:0050710) -5.920.007NLRP12, NLRP3
positive regulation of interleukin-1 secretion (GO:0050716) -6.550.002NLRC4, NLRP12, NLRP3
protein maturation (GO:0051604) NEW4.480.003NLRC4, NLRP12, NLRP3
positive regulation of protein secretion (GO:0050714) -4.390.017NLRC4, NLRP12, NLRP3
positive regulation of interleukin-1 beta secretion (GO:0050718) -6.590.002NLRC4, NLRP12, NLRP3
negative regulation of NF-kappaB transcription factor activity (GO:0032088) -5.510.031NLRC4, NLRP12, NLRP3
immune system process (GO:0002376) -2.290.045PLCG2, NLRC4, NLRP12, NLRP3
regulation of cysteine-type endopeptidase activity (GO:2000116) -4.370.044NLRC4, NLRP12, NLRP3
negative regulation of type I interferon production (GO:0032480) NEW6.070.028NLRC4, NLRP3
regulation of peptidase activity (GO:0052547) -3.750.014NLRC4, NLRP12, NLRP3
positive regulation of interleukin-1 beta production (GO:0032731) -6.330.0NLRC4, NLRP12, NLRP3
negative regulation of cytokine production (GO:0001818) -4.40.035NLRC4, NLRP12, NLRP3
positive regulation of interleukin-1 production (GO:0032732) -6.150.0NLRC4, NLRP12, NLRP3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.284PLCG2, NLRC4, NLRP12, NLRP3
cell part (GO:0044464) 0.114PLCG2, NLRC4, NLRP12, NLRP3
membrane-bounded organelle (GO:0043227) 0.474PLCG2, NLRC4, NLRP12, NLRP3
organelle (GO:0043226) 0.44PLCG2, NLRC4, NLRP12, NLRP3
cytoplasm (GO:0005737) 1.013NLRC4, NLRP12, NLRP3
intracellular membrane-bounded organelle (GO:0043231) 0.63NLRC4, NLRP12, NLRP3
cytosol (GO:0005829) 1.683PLCG2, NLRC4, NLRP3
intracellular organelle (GO:0043229) 0.513NLRC4, NLRP12, NLRP3
cytoplasmic part (GO:0044444) 0.823PLCG2, NLRC4, NLRP3
nucleus (GO:0005634) 1.073NLRC4, NLRP12, NLRP3
protein complex (GO:0043234) 1.512NLRC4, NLRP3
inflammasome complex (GO:0061702) 7.322NLRC4, NLRP3
cytosolic part (GO:0044445) 4.342NLRC4, NLRP3
macromolecular complex (GO:0032991) 1.352NLRC4, NLRP3
intracellular (GO:0005622) 2.372PLCG2, NLRC4

NET-GE enrichment

Term New enriched termICP valueGenes
NLRP3 inflammasome complex (GO:0072559) NEW7.720.022NLRC4, NLRP3