| Disease ID | Disease name | Source of annotation with ADD1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 145500 | HYPERTENSION, ESSENTIAL | OMIM | link to OMIM | 13 | RGS5, PTGIS, ADD1, NOS3, UMOD, AGT, ECE1, CYP3A5, ATP1B1, NOS2, GNB3, AGTR1, SELE |
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| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Unfolded Protein Response (UPR) | R-HSA-381119 | 6.56 |
| Caspase-mediated cleavage of cytoskeletal proteins | R-HSA-264870 | 9.4 |
| Apoptotic cleavage of cellular proteins | R-HSA-111465 | 7.73 |
| Miscellaneous transport and binding events | R-HSA-5223345 | 8.66 |
| Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
| XBP1(S) activates chaperone genes | R-HSA-381038 | 7.25 |
| Apoptotic execution phase | R-HSA-75153 | 7.28 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| IRE1alpha activates chaperones | R-HSA-381070 | 7.2 |
| Apoptosis | R-HSA-109581 | 5.68 |
| GO term | GO ID | GO IC |
|---|---|---|
| protein heterodimerization activity | GO:0046982 | 3.64 |
| protein binding | GO:0005515 | 0.46 |
| cytoskeletal protein binding | GO:0008092 | 3.02 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| poly(A) RNA binding | GO:0044822 | 2.69 |
| transcription factor binding | GO:0008134 | 3.46 |
| actin filament binding | GO:0051015 | 4.93 |
| structural molecule activity | GO:0005198 | 3.1 |
| actin binding | GO:0003779 | 3.74 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| calmodulin binding | GO:0005516 | 4.55 |
| protein complex binding | GO:0032403 | 3.09 |
| protein dimerization activity | GO:0046983 | 2.72 |
| spectrin binding | GO:0030507 | 6.48 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| identical protein binding | GO:0042802 | 2.63 |
| RNA binding | GO:0003723 | 2.36 |