Disease ID | Disease name | Source of annotation with CYP3A5 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
145500 | HYPERTENSION, ESSENTIAL | OMIM | link to OMIM | 13 | RGS5, PTGIS, ADD1, NOS3, UMOD, AGT, ECE1, CYP3A5, ATP1B1, NOS2, GNB3, AGTR1, SELE |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Metabolism of xenobiotics by cytochrome P450 | hsa00980 | 6.48 |
Drug metabolism - cytochrome P450 | hsa00982 | 6.6 |
Chemical carcinogenesis | hsa05204 | 6.36 |
Metabolic pathways | hsa01100 | 2.49 |
Steroid hormone biosynthesis | hsa00140 | 6.93 |
Retinol metabolism | hsa00830 | 6.79 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Xenobiotics | R-HSA-211981 | 8.66 |
Biological oxidations | R-HSA-211859 | 5.55 |
Aflatoxin activation and detoxification | R-HSA-5423646 | 8.66 |
Cytochrome P450 - arranged by substrate type | R-HSA-211897 | 7.08 |
Phase 1 - Functionalization of compounds | R-HSA-211945 | 6.7 |
Metabolism | R-HSA-1430728 | 2.34 |
GO term | GO ID | GO IC |
---|---|---|
cation binding | GO:0043169 | 1.4 |
monooxygenase activity | GO:0004497 | 5.1 |
oxygen binding | GO:0019825 | 5.89 |
transition metal ion binding | GO:0046914 | 2.48 |
heme binding | GO:0020037 | 4.86 |
tetrapyrrole binding | GO:0046906 | 4.8 |
organic cyclic compound binding | GO:0097159 | 1.05 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | GO:0016705 | 4.65 |
ion binding | GO:0043167 | 1.36 |
aromatase activity | GO:0070330 | 6.56 |
catalytic activity | GO:0003824 | 1.05 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | GO:0016712 | 6.37 |
binding | GO:0005488 | 0.18 |
iron ion binding | GO:0005506 | 4.65 |
metal ion binding | GO:0046872 | 1.41 |
heterocyclic compound binding | GO:1901363 | 1.06 |
oxidoreductase activity | GO:0016491 | 3.12 |