Disease table of HYPERTENSION, ESSENTIAL OMIM ID: 145500

Gene-disease associations table

Gene	Associated with HYPERTENSION, ESSENTIAL in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
NOS2	OMIM	HGNC link	17q11.2	2	611162, 145500
CYP3A5	OMIM	HGNC link	7q22.1	1	145500
ADD1	OMIM	HGNC link	4p16.3	1	145500
SELE	OMIM	HGNC link	1q24.2	1	145500
UMOD	ClinVar	HGNC link	16p12.3	4	PS162000, 603860, 609886, 145500
GNB3	OMIM	HGNC link	12p13.31	1	145500
ATP1B1	OMIM	HGNC link	1q24.2	1	145500
RGS5	OMIM	HGNC link	1q23.3	1	145500
NOS3	OMIM	HGNC link	7q36.1	4	145500, PS189800, 104300, 601367
PTGIS	ClinVar, OMIM	HGNC link	20q13.13	1	145500
ECE1	OMIM	HGNC link	1p36.12	2	613870, 145500
AGTR1	OMIM	HGNC link	3q24	2	145500, 267430
AGT	OMIM	HGNC link	1q42.2	3	PS189800, 267430, 145500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
1q24.2	2	ATP1B1, SELE

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
1q24	2	ATP1B1, SELE

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
1q2	3	ATP1B1, RGS5, SELE

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	4	ATP1B1, RGS5, AGT, SELE
7q	2	NOS3, CYP3A5

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
1	5	ATP1B1, RGS5, AGT, SELE, ECE1
7	2	NOS3, CYP3A5

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	NOS2, CYP3A5
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	NOS2, NOS3
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	4	SELE, NOS3, AGT, NOS2
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	4	SELE, NOS3, AGT, NOS2
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	4	CYP3A5, AGT, NOS3, AGTR1
SP3	NO	109	DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC6	3	CYP3A5, NOS3, AGTR1

regulated gene	associated to this disease	# TFs	TFs
NOS2	YES	16	APC, XBP1, STAT2, RELA, MTA1, NFKB1, YY1, FOSL2, IKBKB, NFKBIA, JUN, KLF6, JUND, FOS, KLF5, STAT1
CYP3A5	YES	3	SP1, SP3, YY1
SELE	YES	7	ATF3, STAT6, HOXA9, RELA, REL, NFKB1, SIRT1
ATP1B1	YES	3	NR3C2, PGR, NR3C1
NOS3	YES	11	SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF2
ECE1	YES	1	ETS1
AGTR1	YES	5	SP1, SP3, SND1, ETV4, HIF1A
AGT	YES	5	SP1, YBX1, NFKB1, USF1, RELA

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NOS2	ADD1	No	2	HSPH1, VCP
NOS2	SELE	No	1	LGALS3BP
NOS2	ATP1B1	No	2	ATP2A2, PSMD6
NOS2	NOS3	No	3	CAV1, CALM1, HSP90AA1
NOS2	PTGIS	No	1	CAV1
NOS2	ECE1	No	1	SSR4
NOS2	AGTR1	No	1	CAV1
ADD1	ATP1B1	No	1	NTRK1
GNB3	RGS5	No	3	GNAI3, GNAI2, GNAQ
ATP1B1	NOS3	No	2	PAXIP1, ELAVL1
RGS5	NOS3	No	1	APP
RGS5	PTGIS	No	1	APP
NOS3	PTGIS	No	2	CAV1, APP
NOS3	AGTR1	No	1	CAV1
PTGIS	AGTR1	No	1	CAV1
ECE1	AGT	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NOS2	ADD1	No	-	1	UBC
NOS2	SELE	No	-	3	JUN, ATF2, RELA
NOS2	ATP1B1	No	-	1	UBC
NOS2	NOS3	No	-	15	SP1, RAC1, CALM1, ARNT, CALML3, ARHGEF7, CALM2, CALML5, HSP90AA1, ESR2, JUN, ATF2, SRC, CALML6, HIF1A
NOS2	PTGIS	No	-	2	PTGS2, ESR2
NOS2	AGTR1	No	-	1	JAK2
NOS2	AGT	No	-	3	SRC, PPARA, HIF1A
ADD1	ATP1B1	No	-	1	UBC
SELE	NOS3	No	-	3	PRKCD, JUN, ATF2
SELE	AGT	No	-	1	CREBBP
ATP1B1	NOS3	No	-	1	PRKACA
ATP1B1	AGT	No	-	3	PRKACG, MAPK1, PRKACB
RGS5	NOS3	No	-	3	GNAO1, GNAI3, GNAI1
RGS5	AGTR1	No	-	1	GNAQ
RGS5	AGT	No	-	3	GNAI3, GNAI1, GNAQ
NOS3	PTGIS	No	-	1	ESR2
NOS3	ECE1	No	-	2	INS, EDN1
NOS3	AGTR1	Yes	expression, activation, binding	16	PTK2B, PLCG1, EDNRA, AVP, GNG2, OXT, GNRH1, EDNRB, INS, EDN1, GNB1, BDKRB2, RHOA, KNG1, OLR1, GCG
NOS3	AGT	No	-	28	EDNRB, EDNRA, BDKRB2, GNG2, OXT, PLCG1, TP53, APLN, KNG1, GNAI1, GCG, INS, CXCL12, ACE, RAF1, GNB1, AVP, AGTR1, CNR1, DNM1, SRC, EDN1, STAT3, GNRH1, GNAI3, IL6, PTGER3, HIF1A
ECE1	AGTR1	No	-	3	INS, FOS, EDN1
ECE1	AGT	No	-	3	INS, FOS, EDN1
AGTR1	AGT	Yes	binding	128	PLCG1, GPR17, KISS1, EDN1, XCL1, PTGFR, GPR65, GHSR, CYSLTR2, GPRC6A, UTS2, EDN3, CYSLTR1, EDN2, NPS, CHRM5, SAA1, NMUR1, XCR1, F2R, GNA14, HCRT, LPAR6, FFAR1, GNRH2, GNRHR, F2RL3, GPR68, INS, ANXA1, GRM1, EDNRB, GNAQ, GNA11, OXT, GRP, PTAFR, CASR, F2RL1, LPAR3, ACE2, PROK2, MLN, TAC3, GCG, OPN4, FFAR3, NPFF, NPFFR2, P2RY1, F2RL2, FFAR2, PROK1, QRFP, XCL2, NTS, LRP2, TRH, GPR132, GRPR, ADRA1B, QRFPR, HCRTR2, P2RY10, HRH1, EDNRA, GNG2, FPR2, TBXA2R, MLNR, CCKBR, FOS, APP, GNA15, NMBR, UTS2R, LPAR1, CCK, BDKRB2, TAC1, MCHR2, NMB, NTSR2, LPAR5, AVPR1A, HCRTR1, OXTR, GCGR, TRHR, LTB4R, GNRH1, GPR4, BDKRB1, P2RY2, AVP, P2RY6, LTB4R2, PMCH, HTR2A, GRM5, NPSR1, KNG1, CCKAR, KISS1R, NTSR1, TACR3, ARRB1, ADRBK1, NMUR2, GNB1, NPFFR1, MTRNR2L2, CHRM1, HTR2B, TACR2, TACR1, NMU, CHRM3, PTGER1, PROKR2, UTS2D, LPAR4, NMS, ADRA1D, PROKR1, ADRA1A, MCHR1, LPAR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
NOS2	NOS3	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	4	CYP3A5, NOS2, NOS3, PTGIS
cGMP-PKG signaling pathway	hsa04022	5.32	3	NOS3, ATP1B1, AGTR1
Calcium signaling pathway	hsa04020	5.22	3	NOS2, NOS3, AGTR1
Pathways in cancer	hsa05200	3.98	3	NOS2, GNB3, AGTR1
HIF-1 signaling pathway	hsa04066	5.9	2	NOS2, NOS3
Renin-angiotensin system	hsa04614	8.68	2	AGT, AGTR1
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	ATP1B1, AGTR1
Arginine and proline metabolism	hsa00330	6.84	2	NOS2, NOS3
PI3K-Akt signaling pathway	hsa04151	4.21	2	NOS3, GNB3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Vascular smooth muscle contraction (hsa04270)	NEW	5.74	0.032	NOS2, AGT, NOS3, AGTR1
Renin-angiotensin system (hsa04614)	-	8.68	0.018	NOS3, AGT, AGTR1
Infectious diseases: Parasitic	NEW	4.46	0.019	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
Chemokine signaling pathway (hsa04062)	NEW	5.19	0.008	SELE, NOS3, AGT, NOS2, GNB3
Nervous system	NEW	3.77	0.021	NOS2, SELE, AGT, AGTR1, CYP3A5, NOS3, GNB3

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	5	CYP3A5, AGT, NOS3, PTGIS, GNB3
Hemostasis	R-HSA-109582	3.98	5	SELE, NOS3, NOS2, ATP1B1, GNB3
Signal Transduction	R-HSA-162582	1.78	4	GNB3, AGT, NOS3, AGTR1
Signaling by GPCR	R-HSA-372790	2.68	3	GNB3, AGT, AGTR1
GPCR downstream signaling	R-HSA-388396	3.07	3	GNB3, AGT, AGTR1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	GNB3, AGT, AGTR1
Transmembrane transport of small molecules	R-HSA-382551	3.79	3	GNB3, ADD1, ATP1B1
Metabolism of proteins	R-HSA-392499	3.41	3	ADD1, AGT, GNB3
Platelet homeostasis	R-HSA-418346	6.68	3	NOS2, NOS3, GNB3
GPCR ligand binding	R-HSA-500792	4.19	3	GNB3, AGT, AGTR1
G alpha (q) signalling events	R-HSA-416476	5.42	3	GNB3, AGT, AGTR1
Phagosomal maturation (early endosomal stage)	R-HSA-1222556	7.89	2	NOS2, NOS3
Infectious disease	R-HSA-5663205	4.47	2	NOS2, NOS3
Cytochrome P450 - arranged by substrate type	R-HSA-211897	7.08	2	CYP3A5, PTGIS
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34	2	NOS2, NOS3
Biological oxidations	R-HSA-211859	5.55	2	CYP3A5, PTGIS
G alpha (i) signalling events	R-HSA-418594	5.1	2	GNB3, AGT
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	AGT, AGTR1
Peptide ligand-binding receptors	R-HSA-375276	5.41	2	AGT, AGTR1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	2	SELE, ATP1B1
Phase 1 - Functionalization of compounds	R-HSA-211945	6.7	2	CYP3A5, PTGIS
Peptide hormone metabolism	R-HSA-2980736	6.61	2	GNB3, AGT
Latent infection of Homo sapiens with Mycobacterium tuberculosis	R-HSA-1222352	7.89	2	NOS2, NOS3
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	AGT, PTGIS
Disease	R-HSA-1643685	3.33	2	NOS2, NOS3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Peptide hormone metabolism (R-HSA-2980736)	-	6.61	0.02	NOS2, NOS3, AGT, GNB3
Cytochrome P450 - arranged by substrate type (R-HSA-211897)	-	7.08	0.043	CYP3A5, NOS3, PTGIS
Platelet homeostasis (R-HSA-418346)	-	6.68	0.011	NOS2, NOS3, GNB3
Hemostasis (R-HSA-109582)	-	3.98	0.021	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
Nitric oxide stimulates guanylate cyclase (R-HSA-392154)	-	8.34	0.044	NOS2, NOS3

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	12	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, CYP3A5, NOS3, GNB3, UMOD
protein binding (GO:0005515)	0.46	11	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, UMOD
ion binding (GO:0043167)	1.36	8	NOS2, SELE, ATP1B1, ECE1, PTGIS, CYP3A5, NOS3, UMOD
catalytic activity (GO:0003824)	1.05	7	NOS2, NOS3, ECE1, ATP1B1, PTGIS, GNB3, CYP3A5
metal ion binding (GO:0046872)	1.41	7	NOS2, NOS3, ATP1B1, ECE1, PTGIS, CYP3A5, UMOD
cation binding (GO:0043169)	1.4	7	NOS2, NOS3, ATP1B1, ECE1, PTGIS, CYP3A5, UMOD
organic cyclic compound binding (GO:0097159)	1.05	6	NOS2, ADD1, NOS3, ATP1B1, PTGIS, CYP3A5
heterocyclic compound binding (GO:1901363)	1.06	6	NOS2, ADD1, NOS3, ATP1B1, PTGIS, CYP3A5
monooxygenase activity (GO:0004497)	5.1	4	CYP3A5, NOS2, NOS3, PTGIS
heme binding (GO:0020037)	4.86	4	NOS2, NOS3, CYP3A5, PTGIS
tetrapyrrole binding (GO:0046906)	4.8	4	CYP3A5, NOS2, NOS3, PTGIS
carbohydrate derivative binding (GO:0097367)	2.03	4	SELE, NOS3, NOS2, ATP1B1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)	4.65	4	CYP3A5, NOS2, NOS3, PTGIS
signal transducer activity (GO:0004871)	2.28	4	SELE, AGT, GNB3, AGTR1
protein dimerization activity (GO:0046983)	2.72	4	ADD1, NOS2, AGTR1, ECE1
oxidoreductase activity (GO:0016491)	3.12	4	NOS2, NOS3, CYP3A5, PTGIS
anion binding (GO:0043168)	4.17	3	SELE, NOS3, NOS2
hydrolase activity (GO:0016787)	1.9	3	GNB3, ATP1B1, ECE1
transition metal ion binding (GO:0046914)	2.48	3	CYP3A5, NOS3, PTGIS
cytoskeletal protein binding (GO:0008092)	3.02	3	NOS3, ADD1, GNB3
enzyme regulator activity (GO:0030234)	2.85	3	AGT, ATP1B1, RGS5
carboxylic acid binding (GO:0031406)	4.64	3	SELE, NOS3, NOS2
enzyme activator activity (GO:0008047)	3.56	3	AGT, ATP1B1, RGS5
enzyme binding (GO:0019899)	2.27	3	SELE, GNB3, ATP1B1
nucleotide binding (GO:0000166)	1.96	3	NOS2, NOS3, ATP1B1
small molecule binding (GO:0036094)	1.89	3	NOS2, NOS3, ATP1B1
identical protein binding (GO:0042802)	2.63	3	NOS2, ADD1, ECE1
macromolecular complex binding (GO:0044877)	2.61	3	ADD1, ATP1B1, UMOD
ribonucleotide binding (GO:0032553)	2.19	3	NOS2, NOS3, ATP1B1
calmodulin binding (GO:0005516)	4.55	3	ADD1, NOS2, NOS3
protein complex binding (GO:0032403)	3.09	3	ADD1, ATP1B1, UMOD
iron ion binding (GO:0005506)	4.65	3	CYP3A5, NOS3, PTGIS
molecular function regulator (GO:0098772)	2.51	3	AGT, ATP1B1, RGS5
receptor binding (GO:0005102)	2.43	3	NOS2, AGT, AGTR1
nucleoside phosphate binding (GO:1901265)	1.96	3	NOS2, NOS3, ATP1B1
protein homodimerization activity (GO:0042803)	3.16	3	NOS2, ADD1, ECE1
signaling receptor activity (GO:0038023)	2.49	2	SELE, AGTR1
molecular transducer activity (GO:0060089)	2.32	2	SELE, AGTR1
receptor activity (GO:0004872)	2.32	2	SELE, AGTR1
G-protein coupled receptor binding (GO:0001664)	4.18	2	AGT, AGTR1
amino acid binding (GO:0016597)	5.71	2	NOS2, NOS3
spectrin binding (GO:0030507)	6.48	2	ADD1, GNB3
coenzyme binding (GO:0050662)	4.53	2	NOS2, NOS3
NADP binding (GO:0050661)	5.93	2	NOS2, NOS3
flavin adenine dinucleotide binding (GO:0050660)	5.41	2	NOS2, NOS3
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)	6.07	2	NOS2, NOS3
structural molecule activity (GO:0005198)	3.1	2	ADD1, UMOD
actin binding (GO:0003779)	3.74	2	NOS3, ADD1
FMN binding (GO:0010181)	7.03	2	NOS2, NOS3
arginine binding (GO:0034618)	7.79	2	NOS2, NOS3
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	GNB3, ATP1B1
tetrahydrobiopterin binding (GO:0034617)	8.35	2	NOS2, NOS3
cofactor binding (GO:0048037)	4.16	2	NOS2, NOS3
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	2	ATP1B1, RGS5
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	GNB3, ATP1B1
nitric-oxide synthase activity (GO:0004517)	8.64	2	NOS2, NOS3
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	GNB3, ATP1B1
pyrophosphatase activity (GO:0016462)	3.04	2	GNB3, ATP1B1
transmembrane signaling receptor activity (GO:0004888)	2.57	2	SELE, AGTR1
protein heterodimerization activity (GO:0046982)	3.64	2	ADD1, AGTR1
transmembrane receptor activity (GO:0099600)	2.53	2	SELE, AGTR1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
monooxygenase activity (GO:0004497)	-	5.1	0.0	NOS2, NOS3, CYP3A5, PTGIS
NADPH-hemoprotein reductase activity (GO:0003958)	NEW	8.35	0.001	NOS2, NOS3
bradykinin receptor binding (GO:0031711)	NEW	8.64	0.001	AGT, AGTR1
G-protein coupled receptor binding (GO:0001664)	-	4.18	0.022	SELE, NOS3, AGT, NOS2, AGTR1
NADP binding (GO:0050661)	-	5.93	0.015	NOS2, NOS3, ATP1B1
peptide binding (GO:0042277)	NEW	4.22	0.02	ATP1B1, NOS2, AGT, ECE1, AGTR1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)	-	4.65	0.001	NOS2, NOS3, CYP3A5, PTGIS
ligand-gated ion channel activity (GO:0015276)	NEW	4.8	0.033	NOS2, AGT, NOS3, AGTR1
FMN binding (GO:0010181)	-	7.03	0.04	NOS2, NOS3
protein complex binding (GO:0032403)	-	3.09	0.031	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3, UMOD
iron ion binding (GO:0005506)	-	4.65	0.001	CYP3A5, NOS2, AGT, NOS3, PTGIS
protein homodimerization activity (GO:0042803)	-	3.16	0.016	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, AGTR1, NOS3
arginine binding (GO:0034618)	-	7.79	0.0	NOS2, NOS3
heme binding (GO:0020037)	-	4.86	0.02	CYP3A5, NOS2, NOS3, PTGIS
amide binding (GO:0033218)	NEW	4.14	0.021	ATP1B1, NOS2, AGT, ECE1, AGTR1
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor (GO:0016653)	NEW	7.44	0.004	NOS2, NOS3
tetrahydrobiopterin binding (GO:0034617)	-	8.35	0.0	NOS2, NOS3
cofactor binding (GO:0048037)	-	4.16	0.039	ADD1, NOS2, AGT, NOS3, ATP1B1
tetrapyrrole binding (GO:0046906)	-	4.8	0.027	CYP3A5, NOS2, NOS3, PTGIS
organic acid binding (GO:0043177)	NEW	6.6	0.046	SELE, NOS3, NOS2
nitric-oxide synthase activity (GO:0004517)	-	8.64	0.0	NOS2, NOS3
carboxylic acid binding (GO:0031406)	-	4.64	0.046	SELE, NOS3, NOS2
calmodulin binding (GO:0005516)	-	4.55	0.034	ADD1, NOS2, NOS3
ligand-gated channel activity (GO:0022834)	NEW	4.8	0.033	NOS2, AGT, NOS3, AGTR1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	12	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, CYP3A5, UMOD
biological regulation (GO:0065007)	0.39	12	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, UMOD
regulation of biological process (GO:0050789)	0.45	12	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, UMOD
regulation of cellular process (GO:0050794)	0.5	12	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, UMOD
single-organism process (GO:0044699)	0.48	11	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, CYP3A5, NOS3, UMOD
response to stimulus (GO:0050896)	1.22	10	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, UMOD
single-organism cellular process (GO:0044763)	0.65	10	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3, UMOD
response to stress (GO:0006950)	1.8	9	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3, UMOD
regulation of biological quality (GO:0065008)	1.68	9	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, AGTR1, GNB3, UMOD
regulation of response to stimulus (GO:0048583)	1.54	9	NOS2, AGTR1, RGS5, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3
signal transduction (GO:0007165)	1.28	9	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, PTGIS, GNB3, NOS3
regulation of molecular function (GO:0065009)	1.78	9	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, PTGIS, NOS3
multicellular organismal process (GO:0032501)	1.45	8	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, AGTR1, UMOD
metabolic process (GO:0008152)	0.58	8	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
regulation of metabolic process (GO:0019222)	1.02	8	NOS2, AGTR1, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3
cellular metabolic process (GO:0044237)	0.69	8	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
organic substance metabolic process (GO:0071704)	0.63	8	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
positive regulation of molecular function (GO:0044093)	2.23	8	NOS2, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
positive regulation of biological process (GO:0048518)	1.2	8	NOS2, AGTR1, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3
positive regulation of cellular process (GO:0048522)	1.3	8	NOS2, AGTR1, SELE, ATP1B1, AGT, ECE1, PTGIS, NOS3
developmental process (GO:0032502)	1.36	7	NOS3, AGTR1, ADD1, ECE1, AGT, PTGIS, UMOD
primary metabolic process (GO:0044238)	0.69	7	NOS2, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
regulation of catalytic activity (GO:0050790)	1.97	7	NOS2, RGS5, SELE, ATP1B1, AGT, AGTR1, NOS3
organonitrogen compound metabolic process (GO:1901564)	2.32	7	NOS2, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
regulation of response to external stimulus (GO:0032101)	3.06	7	NOS2, PTGIS, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	NOS2, PTGIS, SELE, ATP1B1, AGT, ECE1, AGTR1
regulation of response to stress (GO:0080134)	2.53	7	NOS2, PTGIS, SELE, ATP1B1, AGT, AGTR1, NOS3
anatomical structure development (GO:0048856)	1.58	7	NOS3, AGTR1, ADD1, ECE1, AGT, PTGIS, UMOD
regulation of cellular metabolic process (GO:0031323)	1.07	7	NOS2, PTGIS, SELE, ECE1, AGT, AGTR1, NOS3
homeostatic process (GO:0042592)	2.61	7	NOS2, ADD1, NOS3, ATP1B1, AGT, AGTR1, UMOD
cellular nitrogen compound metabolic process (GO:0034641)	1.22	7	NOS2, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
nitrogen compound metabolic process (GO:0006807)	1.13	7	NOS2, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5
regulation of multicellular organismal process (GO:0051239)	1.87	7	NOS2, PTGIS, NOS3, ATP1B1, AGT, ECE1, AGTR1
regulation of signaling (GO:0023051)	1.72	7	NOS2, RGS5, NOS3, ATP1B1, AGT, ECE1, PTGIS
negative regulation of biological process (GO:0048519)	1.33	7	NOS2, RGS5, ADD1, NOS3, AGT, PTGIS, UMOD
positive regulation of catalytic activity (GO:0043085)	2.4	7	NOS2, RGS5, SELE, ATP1B1, AGT, AGTR1, NOS3
system process (GO:0003008)	2.3	7	NOS2, NOS3, ATP1B1, AGT, ECE1, AGTR1, UMOD
regulation of hydrolase activity (GO:0051336)	2.53	6	NOS3, RGS5, SELE, ATP1B1, AGT, AGTR1
response to abiotic stimulus (GO:0009628)	2.8	6	NOS2, NOS3, ATP1B1, AGT, ECE1, PTGIS
single-organism metabolic process (GO:0044710)	1.63	6	NOS2, NOS3, ATP1B1, AGT, PTGIS, CYP3A5
regulation of cell communication (GO:0010646)	1.73	6	NOS2, RGS5, NOS3, ECE1, AGT, PTGIS
positive regulation of metabolic process (GO:0009893)	1.74	6	NOS2, SELE, ECE1, AGT, AGTR1, NOS3
regulation of system process (GO:0044057)	3.53	6	NOS2, NOS3, ATP1B1, AGT, ECE1, AGTR1
regulation of transport (GO:0051049)	2.24	6	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
positive regulation of cellular metabolic process (GO:0031325)	1.81	6	NOS2, SELE, ECE1, AGT, AGTR1, NOS3
regulation of anatomical structure size (GO:0090066)	3.78	6	NOS2, ADD1, NOS3, ECE1, AGT, AGTR1
single-organism developmental process (GO:0044767)	1.49	6	NOS3, ADD1, ECE1, AGT, AGTR1, UMOD
regulation of blood circulation (GO:1903522)	4.05	6	NOS2, NOS3, ATP1B1, AGT, ECE1, AGTR1
regulation of defense response (GO:0031347)	3.11	6	NOS2, PTGIS, SELE, ATP1B1, AGT, AGTR1
second-messenger-mediated signaling (GO:0019932)	4.65	6	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
response to chemical (GO:0042221)	1.98	6	NOS2, SELE, ECE1, PTGIS, GNB3, UMOD
cellular homeostasis (GO:0019725)	3.23	6	NOS2, ADD1, NOS3, ATP1B1, AGT, AGTR1
regulation of blood pressure (GO:0008217)	4.72	6	NOS2, NOS3, ECE1, AGT, AGTR1, GNB3
intracellular signal transduction (GO:0035556)	2.39	6	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of localization (GO:0032879)	1.94	6	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
negative regulation of cellular process (GO:0048523)	1.41	6	NOS3, RGS5, ADD1, AGT, PTGIS, UMOD
regulation of primary metabolic process (GO:0080090)	1.08	6	NOS2, PTGIS, NOS3, ECE1, AGT, AGTR1
regulation of tube size (GO:0035150)	4.79	5	NOS2, AGT, NOS3, AGTR1, ECE1
regulation of cellular biosynthetic process (GO:0031326)	1.38	5	PTGIS, NOS2, AGT, NOS3, ECE1
movement of cell or subcellular component (GO:0006928)	2.61	5	UMOD, SELE, ATP1B1, NOS3, AGTR1
circulatory system process (GO:0003013)	4.38	5	NOS2, AGT, NOS3, AGTR1, ECE1
vascular process in circulatory system (GO:0003018)	4.65	5	NOS2, NOS3, AGT, ECE1, AGTR1
regulation of vasodilation (GO:0042312)	5.86	5	NOS2, AGT, NOS3, AGTR1, ECE1
cellular component organization or biogenesis (GO:0071840)	1.22	5	ATP1B1, NOS3, AGT, ADD1, AGTR1
cellular response to stimulus (GO:0051716)	1.97	5	NOS2, AGT, ADD1, PTGIS, GNB3
regulation of blood vessel size (GO:0050880)	4.8	5	NOS2, AGT, NOS3, AGTR1, ECE1
positive regulation of hydrolase activity (GO:0051345)	2.91	5	ATP1B1, SELE, AGT, AGTR1, RGS5
regulation of signal transduction (GO:0009966)	1.84	5	NOS3, AGT, PTGIS, RGS5, ECE1
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	NOS2, AGT, NOS3, PTGIS, ECE1
regulation of inflammatory response (GO:0050727)	4.03	5	PTGIS, SELE, AGT, NOS2, AGTR1
cellular component organization (GO:0016043)	1.24	5	ATP1B1, ADD1, AGT, NOS3, AGTR1
cell migration (GO:0016477)	3.12	5	UMOD, SELE, ATP1B1, NOS3, AGTR1
regulation of cell proliferation (GO:0042127)	2.41	5	NOS2, NOS3, AGT, UMOD, AGTR1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	5	PTGIS, NOS2, AGT, NOS3, ECE1
regulation of biosynthetic process (GO:0009889)	1.37	5	NOS2, NOS3, AGT, PTGIS, ECE1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	5	NOS2, AGT, NOS3, PTGIS, ECE1
response to organic substance (GO:0010033)	2.2	5	PTGIS, SELE, NOS2, UMOD, GNB3
locomotion (GO:0040011)	2.91	5	UMOD, SELE, ATP1B1, NOS3, AGTR1
cell motility (GO:0048870)	3.02	5	UMOD, SELE, ATP1B1, NOS3, AGTR1
regulation of phosphate metabolic process (GO:0019220)	2.35	4	NOS2, AGT, NOS3, ECE1
positive regulation of biosynthetic process (GO:0009891)	2.29	4	NOS2, AGT, NOS3, ECE1
negative regulation of response to stimulus (GO:0048585)	2.52	4	NOS3, AGT, PTGIS, RGS5
positive regulation of response to stimulus (GO:0048584)	2.18	4	PTGIS, AGT, ECE1, AGTR1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	SELE, AGT, ECE1, AGTR1
regulation of cellular component organization (GO:0051128)	2.01	4	SELE, AGT, ADD1, AGTR1
cellular catabolic process (GO:0044248)	2.62	4	CYP3A5, NOS2, NOS3, ECE1
small molecule metabolic process (GO:0044281)	2.38	4	NOS2, ATP1B1, NOS3, PTGIS
response to hypoxia (GO:0001666)	4.13	4	NOS2, ATP1B1, ECE1, PTGIS
regulation of systemic arterial blood pressure (GO:0003073)	5.99	4	NOS3, AGT, ECE1, AGTR1
organic substance catabolic process (GO:1901575)	2.45	4	NOS2, NOS3, CYP3A5, ECE1
regulation of systemic arterial blood pressure by hormone (GO:0001990)	6.43	4	NOS3, AGT, ECE1, AGTR1
endocrine process (GO:0050886)	6.43	4	NOS3, AGT, ECE1, AGTR1
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	NOS2, AGT, NOS3, ECE1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	NOS2, AGT, NOS3, ECE1
regulation of protein metabolic process (GO:0051246)	1.93	4	NOS2, AGT, ECE1, AGTR1
animal organ development (GO:0048513)	2.53	4	NOS3, AGT, ECE1, AGTR1
response to oxygen levels (GO:0070482)	4.02	4	NOS2, ATP1B1, PTGIS, ECE1
regulation of gene expression (GO:0010468)	1.37	4	NOS2, AGT, ATP1B1, PTGIS
macromolecule metabolic process (GO:0043170)	0.83	4	NOS2, AGT, ADD1, ECE1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	NOS2, AGT, NOS3, ECE1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	NOS2, AGT, NOS3, ECE1
transport (GO:0006810)	1.51	4	NOS2, AGT, ADD1, ATP1B1
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	NOS2, AGT, NOS3, ECE1
regulation of muscle system process (GO:0090257)	4.51	4	NOS3, AGT, ATP1B1, ECE1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	NOS2, AGT, NOS3, ECE1
establishment of localization (GO:0051234)	1.48	4	NOS2, AGT, ADD1, ATP1B1
catabolic process (GO:0009056)	2.38	4	NOS2, NOS3, CYP3A5, ECE1
localization (GO:0051179)	1.4	4	NOS2, AGT, ADD1, ATP1B1
oxidation-reduction process (GO:0055114)	2.91	4	NOS2, NOS3, CYP3A5, PTGIS
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	6.36	4	NOS3, AGT, ECE1, AGTR1
single-multicellular organism process (GO:0044707)	1.78	4	ADD1, AGT, NOS3, AGTR1
response to external stimulus (GO:0009605)	2.55	4	SELE, AGT, NOS2, ECE1
response to decreased oxygen levels (GO:0036293)	4.09	4	NOS2, ATP1B1, PTGIS, ECE1
chemical homeostasis (GO:0048878)	2.97	4	ATP1B1, AGT, UMOD, AGTR1
immune system process (GO:0002376)	2.29	4	SELE, ATP1B1, NOS2, UMOD
organonitrogen compound catabolic process (GO:1901565)	3.91	4	NOS2, NOS3, CYP3A5, ECE1
protein localization (GO:0008104)	2.36	3	NOS2, AGT, ATP1B1
regulation of secretion (GO:0051046)	3.2	3	NOS2, AGT, AGTR1
regulation of vasoconstriction (GO:0019229)	5.51	3	AGT, ECE1, AGTR1
regulation of homeostatic process (GO:0032844)	3.65	3	AGT, UMOD, AGTR1
cation homeostasis (GO:0055080)	3.46	3	AGT, ATP1B1, AGTR1
muscle system process (GO:0003012)	4.18	3	NOS3, AGT, ATP1B1
inorganic ion homeostasis (GO:0098771)	3.43	3	AGT, ATP1B1, AGTR1
positive regulation of nucleotide metabolic process (GO:0045981)	4.85	3	NOS2, NOS3, ECE1
organic cyclic compound metabolic process (GO:1901360)	1.26	3	CYP3A5, ATP1B1, PTGIS
negative regulation of signal transduction (GO:0009968)	2.75	3	NOS3, AGT, RGS5
positive regulation of signal transduction (GO:0009967)	2.5	3	AGT, ECE1, PTGIS
regulation of programmed cell death (GO:0043067)	2.49	3	NOS3, AGT, PTGIS
negative regulation of molecular function (GO:0044092)	2.74	3	NOS3, AGT, PTGIS
macromolecule localization (GO:0033036)	2.34	3	NOS2, AGT, ATP1B1
calcium-mediated signaling (GO:0019722)	5.24	3	SELE, ATP1B1, AGTR1
positive regulation of vasodilation (GO:0045909)	6.26	3	NOS2, AGT, NOS3
establishment of protein localization (GO:0045184)	2.53	3	NOS2, AGT, ATP1B1
oxoacid metabolic process (GO:0043436)	3.12	3	NOS2, NOS3, PTGIS
cellular amide metabolic process (GO:0043603)	3.23	3	AGT, ECE1, PTGIS
negative regulation of signaling (GO:0023057)	2.65	3	NOS3, AGT, RGS5
protein metabolic process (GO:0019538)	1.45	3	NOS2, AGT, ECE1
positive regulation of purine nucleotide biosynthetic process (GO:1900373)	5.09	3	NOS2, NOS3, ECE1
regulation of purine nucleotide biosynthetic process (GO:1900371)	4.8	3	NOS2, NOS3, ECE1
cellular response to stress (GO:0033554)	2.51	3	ADD1, AGT, PTGIS
negative regulation of metabolic process (GO:0009892)	1.93	3	NOS2, AGT, PTGIS
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	NOS3, AGT, PTGIS
regulation of vasculature development (GO:1901342)	4.26	3	NOS3, AGT, PTGIS
regulation of apoptotic process (GO:0042981)	2.5	3	NOS3, AGT, PTGIS
regulation of oxidoreductase activity (GO:0051341)	5.27	3	NOS3, AGT, AGTR1
cellular macromolecule metabolic process (GO:0044260)	0.93	3	NOS2, AGT, ADD1
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	3	GNB3, AGT, AGTR1
response to cytokine (GO:0034097)	3.84	3	SELE, NOS2, PTGIS
regulation of developmental process (GO:0050793)	2.1	3	NOS3, AGT, PTGIS
regulation of heart contraction (GO:0008016)	4.35	3	NOS3, AGT, ATP1B1
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	3	AGT, PTGIS, AGTR1
defense response (GO:0006952)	2.78	3	SELE, NOS2, UMOD
positive regulation of blood circulation (GO:1903524)	5.16	3	NOS2, AGT, NOS3
single-organism transport (GO:0044765)	2.18	3	NOS2, AGT, ATP1B1
positive regulation of lipase activity (GO:0060193)	5.54	3	SELE, AGT, AGTR1
regulation of lipase activity (GO:0060191)	5.31	3	SELE, AGT, AGTR1
ion homeostasis (GO:0050801)	3.42	3	AGT, ATP1B1, AGTR1
positive regulation of signaling (GO:0023056)	2.41	3	AGT, ECE1, PTGIS
cellular biosynthetic process (GO:0044249)	1.37	3	NOS2, NOS3, PTGIS
negative regulation of cell communication (GO:0010648)	2.66	3	NOS3, AGT, RGS5
cellular response to chemical stimulus (GO:0070887)	2.57	3	NOS2, GNB3, PTGIS
positive regulation of cell communication (GO:0010647)	2.41	3	AGT, ECE1, PTGIS
positive regulation of nucleotide biosynthetic process (GO:0030810)	5.09	3	NOS2, NOS3, ECE1
biological adhesion (GO:0022610)	2.81	3	SELE, ATP1B1, UMOD
regulation of sodium ion transport (GO:0002028)	5.4	3	NOS3, AGT, ATP1B1
response to oxygen-containing compound (GO:1901700)	2.57	3	SELE, NOS2, GNB3
cellular metal ion homeostasis (GO:0006875)	3.75	3	AGT, ATP1B1, AGTR1
cellular ion homeostasis (GO:0006873)	3.57	3	AGT, ATP1B1, AGTR1
cellular cation homeostasis (GO:0030003)	3.6	3	AGT, ATP1B1, AGTR1
regulation of cyclic nucleotide metabolic process (GO:0030799)	4.69	3	NOS2, NOS3, ECE1
cellular chemical homeostasis (GO:0055082)	3.4	3	AGT, ATP1B1, AGTR1
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	AGT, ECE1, AGTR1
regulation of nucleotide biosynthetic process (GO:0030808)	4.79	3	NOS2, NOS3, ECE1
organic acid metabolic process (GO:0006082)	3.01	3	NOS2, NOS3, PTGIS
positive regulation of developmental process (GO:0051094)	2.77	3	NOS3, AGT, PTGIS
positive regulation of cyclic nucleotide biosynthetic process (GO:0030804)	5.14	3	NOS2, NOS3, ECE1
positive regulation of cyclic nucleotide metabolic process (GO:0030801)	5.05	3	NOS2, NOS3, ECE1
regulation of cyclic nucleotide biosynthetic process (GO:0030802)	4.85	3	NOS2, NOS3, ECE1
carboxylic acid metabolic process (GO:0019752)	3.12	3	NOS2, NOS3, PTGIS
leukocyte migration (GO:0050900)	4.19	3	SELE, ATP1B1, UMOD
regulation of cell death (GO:0010941)	2.43	3	NOS3, AGT, PTGIS
regulation of muscle adaptation (GO:0043502)	5.78	3	NOS3, AGT, ECE1
regulation of ion transport (GO:0043269)	3.4	3	NOS3, AGT, ATP1B1
positive regulation of transport (GO:0051050)	2.9	3	SELE, AGT, ATP1B1
regulation of angiogenesis (GO:0045765)	4.36	3	NOS3, AGT, PTGIS
cellular response to organic substance (GO:0071310)	2.78	3	NOS2, GNB3, PTGIS
organic substance transport (GO:0071702)	2.15	3	NOS2, AGT, ATP1B1
regulation of hormone levels (GO:0010817)	3.56	3	NOS2, AGT, ECE1
regulation of metal ion transport (GO:0010959)	3.94	3	NOS3, AGT, ATP1B1
reproductive process (GO:0022414)	2.55	3	NOS3, AGT, PTGIS
biosynthetic process (GO:0009058)	1.32	3	NOS2, NOS3, PTGIS
metal ion homeostasis (GO:0055065)	3.61	3	AGT, ATP1B1, AGTR1
cell adhesion (GO:0007155)	2.82	3	SELE, ATP1B1, UMOD
nitric oxide mediated signal transduction (GO:0007263)	6.78	3	NOS2, AGT, NOS3
single-organism localization (GO:1902578)	2.09	3	NOS2, AGT, ATP1B1
organelle organization (GO:0006996)	2.02	3	NOS3, ADD1, ATP1B1
regulation of purine nucleotide metabolic process (GO:1900542)	4.41	3	NOS2, NOS3, ECE1
positive regulation of purine nucleotide metabolic process (GO:1900544)	4.85	3	NOS2, NOS3, ECE1
regulation of calcium ion transport (GO:0051924)	4.38	3	NOS3, AGT, ATP1B1
positive regulation of phospholipase activity (GO:0010518)	5.76	3	SELE, AGT, AGTR1
regulation of ion homeostasis (GO:2000021)	4.44	3	AGT, UMOD, AGTR1
regulation of multicellular organismal development (GO:2000026)	2.31	3	NOS3, AGT, PTGIS
protein transport (GO:0015031)	2.62	3	NOS2, AGT, ATP1B1
regulation of nucleotide metabolic process (GO:0006140)	4.38	3	NOS2, NOS3, ECE1
regulation of phospholipase activity (GO:0010517)	5.57	3	SELE, AGT, AGTR1
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	NOS3, AGT
developmental growth (GO:0048589)	4.05	2	ADD1, AGT
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	NOS3, AGT
angiotensin-activated signaling pathway (GO:0038166)	7.09	2	AGT, AGTR1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	AGT, PTGIS
tissue remodeling (GO:0048771)	5.54	2	NOS3, AGT
positive regulation of defense response (GO:0031349)	3.83	2	AGT, AGTR1
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	4.97	2	ECE1, RGS5
renal system process (GO:0003014)	5.17	2	AGT, AGTR1
positive regulation of angiogenesis (GO:0045766)	4.93	2	NOS3, PTGIS
cell surface receptor signaling pathway (GO:0007166)	2.09	2	NOS3, AGT
sodium ion homeostasis (GO:0055078)	6.36	2	AGT, ATP1B1
mitochondrion organization (GO:0007005)	3.69	2	NOS3, ATP1B1
single-organism catabolic process (GO:0044712)	3.21	2	NOS2, NOS3
hormone metabolic process (GO:0042445)	4.64	2	AGT, ECE1
positive regulation of inflammatory response (GO:0050729)	4.98	2	AGT, AGTR1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	NOS2, AGT
regulation of cardiac conduction (GO:1903779)	5.57	2	AGT, ATP1B1
response to external biotic stimulus (GO:0043207)	3.13	2	SELE, NOS2
cellular macromolecule localization (GO:0070727)	3.1	2	AGT, ATP1B1
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	2	AGT, PTGIS
kidney development (GO:0001822)	4.79	2	AGT, AGTR1
response to mechanical stimulus (GO:0009612)	4.41	2	AGT, ECE1
rhythmic process (GO:0048511)	4.02	2	NOS2, NOS3
positive regulation of lipid metabolic process (GO:0045834)	4.88	2	AGT, AGTR1
heterocycle metabolic process (GO:0046483)	1.31	2	ATP1B1, PTGIS
regulation of sodium ion transmembrane transport (GO:1902305)	5.86	2	AGT, ATP1B1
negative regulation of transport (GO:0051051)	3.6	2	NOS3, AGT
macromolecular complex remodeling (GO:0034367)	6.55	2	AGT, AGTR1
protein-lipid complex remodeling (GO:0034368)	6.55	2	AGT, AGTR1
plasma lipoprotein particle remodeling (GO:0034369)	6.55	2	AGT, AGTR1
single organism reproductive process (GO:0044702)	2.73	2	NOS3, PTGIS
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	AGT, PTGIS
(GO:0010872)	7.43	2	AGT, AGTR1
(GO:0010873)	7.65	2	AGT, AGTR1
regulation of cyclase activity (GO:0031279)	5.32	2	NOS2, NOS3
cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)	4.39	2	SELE, UMOD
multi-organism process (GO:0051704)	2.65	2	NOS2, AGT
regulation of phosphorylation (GO:0042325)	2.5	2	AGT, ECE1
regulation of phospholipase C activity (GO:1900274)	6.07	2	SELE, AGT
response to biotic stimulus (GO:0009607)	3.09	2	SELE, NOS2
phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	5.38	2	AGT, AGTR1
organic acid catabolic process (GO:0016054)	4.44	2	NOS2, NOS3
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	AGT, PTGIS
regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	7.16	2	AGT, AGTR1
response to interleukin-1 (GO:0070555)	5.07	2	SELE, PTGIS
embryo development ending in birth or egg hatching (GO:0009792)	4.35	2	NOS3, ADD1
cell-cell adhesion (GO:0098609)	3.34	2	SELE, UMOD
calcium ion homeostasis (GO:0055074)	3.97	2	ATP1B1, AGTR1
regulation of membrane potential (GO:0042391)	3.89	2	AGT, ATP1B1
positive regulation of muscle hypertrophy (GO:0014742)	6.64	2	AGT, ECE1
regulation of muscle hypertrophy (GO:0014743)	6.12	2	AGT, ECE1
small molecule catabolic process (GO:0044282)	3.99	2	NOS2, NOS3
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	2	AGT, ATP1B1
regulation of cation transmembrane transport (GO:1904062)	4.4	2	AGT, ATP1B1
cellular amino acid catabolic process (GO:0009063)	5.37	2	NOS2, NOS3
negative regulation of gene expression (GO:0010629)	2.48	2	NOS2, AGT
single organism cell adhesion (GO:0098602)	3.63	2	SELE, UMOD
superoxide metabolic process (GO:0006801)	6.23	2	NOS2, NOS3
glutamine family amino acid catabolic process (GO:0009065)	6.55	2	NOS2, NOS3
glutamine family amino acid metabolic process (GO:0009064)	5.52	2	NOS2, NOS3
actin filament-based process (GO:0030029)	3.94	2	SELE, ADD1
positive regulation of phospholipase C activity (GO:0010863)	6.15	2	SELE, AGT
positive regulation of oxidoreductase activity (GO:0051353)	5.94	2	AGT, AGTR1
nitric oxide biosynthetic process (GO:0006809)	7.16	2	NOS2, NOS3
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure (GO:0003072)	8.63	2	AGT, AGTR1
cellular protein metabolic process (GO:0044267)	1.63	2	NOS2, AGT
renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	6.68	2	AGT, AGTR1
negative regulation of hydrolase activity (GO:0051346)	3.74	2	NOS3, AGT
regulation of blood vessel size by renin-angiotensin (GO:0002034)	8.63	2	AGT, AGTR1
positive regulation of lyase activity (GO:0051349)	5.65	2	NOS2, NOS3
cellular sodium ion homeostasis (GO:0006883)	6.84	2	AGT, ATP1B1
reactive oxygen species biosynthetic process (GO:1903409)	6.59	2	NOS2, NOS3
regulation of transmembrane transport (GO:0034762)	3.74	2	AGT, ATP1B1
regulation of sodium ion transmembrane transporter activity (GO:2000649)	6.09	2	AGT, ATP1B1
cellular monovalent inorganic cation homeostasis (GO:0030004)	5.19	2	AGT, ATP1B1
positive regulation of cellular component organization (GO:0051130)	2.68	2	SELE, AGT
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	2	AGT, AGTR1
lipid metabolic process (GO:0006629)	2.68	2	CYP3A5, PTGIS
protein secretion (GO:0009306)	4.97	2	NOS2, AGT
ion transport (GO:0006811)	2.66	2	NOS2, ATP1B1
tissue development (GO:0009888)	3.27	2	PTGIS, UMOD
activation of phospholipase C activity (GO:0007202)	6.43	2	SELE, AGT
macromolecule modification (GO:0043412)	1.73	2	NOS2, AGT
in utero embryonic development (GO:0001701)	4.4	2	NOS3, ADD1
regulation of intracellular signal transduction (GO:1902531)	2.31	2	AGT, ECE1
regulation of systemic arterial blood pressure by endothelin (GO:0003100)	8.12	2	NOS3, ECE1
secretion (GO:0046903)	3.38	2	NOS2, AGT
regulation of cGMP biosynthetic process (GO:0030826)	6.64	2	NOS2, NOS3
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	NOS2, NOS3
intracellular transport (GO:0046907)	2.67	2	AGT, ATP1B1
cellular response to cytokine stimulus (GO:0071345)	4.33	2	NOS2, PTGIS
regulation of transmembrane transporter activity (GO:0022898)	4.52	2	AGT, ATP1B1
regulation of NAD(P)H oxidase activity (GO:0033860)	7.94	2	AGT, AGTR1
regulation of multi-organism process (GO:0043900)	3.6	2	NOS2, ATP1B1
(GO:0033864)	8.63	2	AGT, AGTR1
regulation of lyase activity (GO:0051339)	5.3	2	NOS2, NOS3
blood vessel remodeling (GO:0001974)	6.23	2	NOS3, AGT
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	AGT, PTGIS
peptide metabolic process (GO:0006518)	3.44	2	AGT, ECE1
negative regulation of response to external stimulus (GO:0032102)	4.18	2	NOS3, PTGIS
positive regulation of response to external stimulus (GO:0032103)	4.17	2	AGT, AGTR1
embryo development (GO:0009790)	4.2	2	NOS3, ADD1
low-density lipoprotein particle remodeling (GO:0034374)	7.33	2	AGT, AGTR1
regulation of secretion by cell (GO:1903530)	3.28	2	NOS2, AGT
anatomical structure morphogenesis (GO:0009653)	2.53	2	ADD1, ECE1
negative regulation of catalytic activity (GO:0043086)	3.0	2	NOS3, AGT
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	ATP1B1, AGTR1
negative regulation of protein metabolic process (GO:0051248)	2.82	2	NOS2, AGT
positive regulation of vasculature development (GO:1904018)	4.83	2	NOS3, PTGIS
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	ATP1B1, AGTR1
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	NOS3, AGT
positive regulation of protein metabolic process (GO:0051247)	2.43	2	AGT, AGTR1
regulation of transporter activity (GO:0032409)	4.45	2	AGT, ATP1B1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	AGT, AGTR1
growth (GO:0040007)	3.8	2	ADD1, AGT
protein modification process (GO:0036211)	1.79	2	NOS2, AGT
regulation of protein modification process (GO:0031399)	2.32	2	AGT, ECE1
proteolysis (GO:0006508)	2.73	2	AGT, ECE1
chordate embryonic development (GO:0043009)	4.38	2	NOS3, ADD1
alpha-amino acid metabolic process (GO:1901605)	4.5	2	NOS2, NOS3
alpha-amino acid catabolic process (GO:1901606)	5.54	2	NOS2, NOS3
negative regulation of cell proliferation (GO:0008285)	3.26	2	NOS3, UMOD
positive regulation of cardiac muscle hypertrophy (GO:0010613)	6.64	2	AGT, ECE1
cellular calcium ion homeostasis (GO:0006874)	4.01	2	ATP1B1, AGTR1
reactive oxygen species metabolic process (GO:0072593)	5.14	2	NOS2, NOS3
positive regulation of cell differentiation (GO:0045597)	3.01	2	AGT, AGTR1
negative regulation of ion transport (GO:0043271)	4.94	2	NOS3, AGT
regulation of cell differentiation (GO:0045595)	2.42	2	AGT, AGTR1
regulation of cell growth (GO:0001558)	3.75	2	AGT, AGTR1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	AGT, PTGIS
regulation of renal system process (GO:0098801)	6.12	2	AGT, AGTR1
protein processing (GO:0016485)	4.62	2	AGT, ECE1
cell redox homeostasis (GO:0045454)	5.52	2	NOS2, NOS3
peptide hormone processing (GO:0016486)	6.29	2	AGT, ECE1
transmembrane transport (GO:0055085)	2.72	2	ADD1, ATP1B1
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	AGT, PTGIS
protein maturation (GO:0051604)	4.48	2	AGT, ECE1
regulation of excretion (GO:0044062)	6.36	2	AGT, AGTR1
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	2	AGT, PTGIS
regulation of RNA metabolic process (GO:0051252)	1.52	2	AGT, PTGIS
response to drug (GO:0042493)	3.71	2	NOS2, ECE1
secretion by cell (GO:0032940)	3.59	2	NOS2, AGT
regulation of protein phosphorylation (GO:0001932)	2.57	2	AGT, ECE1
positive regulation of steroid metabolic process (GO:0045940)	6.59	2	AGT, AGTR1
regulation of cytokine production (GO:0001817)	3.4	2	NOS2, AGT
response to molecule of bacterial origin (GO:0002237)	3.99	2	SELE, NOS2
carboxylic acid catabolic process (GO:0046395)	4.58	2	NOS2, NOS3
positive regulation of guanylate cyclase activity (GO:0031284)	7.33	2	NOS2, NOS3
single organismal cell-cell adhesion (GO:0016337)	3.69	2	SELE, UMOD
positive regulation of cyclase activity (GO:0031281)	5.65	2	NOS2, NOS3
regulation of guanylate cyclase activity (GO:0031282)	7.16	2	NOS2, NOS3
macromolecular complex subunit organization (GO:0043933)	2.14	2	AGT, AGTR1
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	AGT, PTGIS
reactive nitrogen species metabolic process (GO:2001057)	6.78	2	NOS2, NOS3
regulation of potassium ion transport (GO:0043266)	5.31	2	NOS3, ATP1B1
positive regulation of cell death (GO:0010942)	3.32	2	AGT, PTGIS
nitric oxide metabolic process (GO:0046209)	7.02	2	NOS2, NOS3
multicellular organism development (GO:0007275)	2.54	2	NOS3, ADD1
cytokine secretion (GO:0050663)	6.07	2	NOS2, AGT
protein-lipid complex subunit organization (GO:0071825)	6.15	2	AGT, AGTR1
plasma lipoprotein particle organization (GO:0071827)	6.23	2	AGT, AGTR1
regulation of ion transmembrane transport (GO:0034765)	3.77	2	AGT, ATP1B1
muscle contraction (GO:0006936)	4.37	2	AGT, ATP1B1
alkaloid metabolic process (GO:0009820)	7.24	2	CYP3A5, PTGIS
response to lipid (GO:0033993)	3.11	2	SELE, NOS2
regulation of growth (GO:0040008)	3.26	2	AGT, AGTR1
cellular amino acid metabolic process (GO:0006520)	4.22	2	NOS2, NOS3
arginine catabolic process (GO:0006527)	7.53	2	NOS2, NOS3
single-organism organelle organization (GO:1902589)	2.68	2	ADD1, ATP1B1
arginine metabolic process (GO:0006525)	6.84	2	NOS2, NOS3
positive regulation of apoptotic process (GO:0043065)	3.38	2	AGT, PTGIS
positive regulation of macrophage derived foam cell differentiation (GO:0010744)	7.02	2	AGT, AGTR1
regulation of renal sodium excretion (GO:0035813)	6.55	2	AGT, AGTR1
positive regulation of programmed cell death (GO:0043068)	3.38	2	AGT, PTGIS
regulation of macrophage derived foam cell differentiation (GO:0010743)	6.4	2	AGT, AGTR1
response to lipopolysaccharide (GO:0032496)	4.03	2	SELE, NOS2
regulation of lipid metabolic process (GO:0019216)	4.08	2	AGT, AGTR1
regulation of steroid metabolic process (GO:0019218)	5.42	2	AGT, AGTR1
cellular protein localization (GO:0034613)	3.11	2	AGT, ATP1B1
cellular protein modification process (GO:0006464)	1.79	2	NOS2, AGT
leukocyte cell-cell adhesion (GO:0007159)	4.26	2	SELE, UMOD
monovalent inorganic cation homeostasis (GO:0055067)	4.93	2	AGT, ATP1B1
establishment of localization in cell (GO:0051649)	2.47	2	AGT, ATP1B1
cell communication (GO:0007154)	3.04	2	AGT, ATP1B1
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	5.88	2	SELE, UMOD
cellular localization (GO:0051641)	2.32	2	AGT, ATP1B1
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	NOS2, GNB3
positive regulation of cGMP metabolic process (GO:0030825)	6.68	2	NOS2, NOS3
regulation of cardiac muscle hypertrophy (GO:0010611)	6.17	2	AGT, ECE1
regulation of cGMP metabolic process (GO:0030823)	6.36	2	NOS2, NOS3
renin-angiotensin regulation of aldosterone production (GO:0002018)	8.34	2	AGT, AGTR1
negative regulation of blood pressure (GO:0045776)	5.99	2	NOS2, NOS3
positive regulation of cGMP biosynthetic process (GO:0030828)	6.78	2	NOS2, NOS3
regulation of cellular component biogenesis (GO:0044087)	3.08	2	ADD1, AGT
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	AGT, ATP1B1
phosphorus metabolic process (GO:0006793)	2.15	2	AGT, ATP1B1
single-organism intracellular transport (GO:1902582)	3.59	2	AGT, ATP1B1
single-organism cellular localization (GO:1902580)	3.16	2	AGT, ATP1B1
intracellular protein transport (GO:0006886)	3.2	2	AGT, ATP1B1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hemostasis (GO:0007599)	NEW	4.5	0.041	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of transport (GO:0051049)	-	2.24	0.017	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
blood coagulation (GO:0007596)	NEW	4.52	0.039	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of vasoconstriction (GO:0019229)	-	5.51	0.004	NOS3, AGT, ECE1, AGTR1
circulatory system process (GO:0003013)	-	4.38	0.015	SELE, NOS3, AGT, NOS2, AGTR1
cell chemotaxis (GO:0060326)	NEW	4.63	0.023	SELE, NOS2, AGT, NOS3, AGTR1
vascular process in circulatory system (GO:0003018)	-	4.65	0.025	NOS2, AGT, NOS3, AGTR1
sodium ion homeostasis (GO:0055078)	-	6.36	0.011	NOS2, AGT, ATP1B1
regulation of anatomical structure size (GO:0090066)	-	3.78	0.014	NOS3, AGT, ADD1, AGTR1
hormone metabolic process (GO:0042445)	-	4.64	0.042	ATP1B1, NOS2, AGT, NOS3, ECE1
regulation of inflammatory response (GO:0050727)	-	4.03	0.015	NOS2, PTGIS, SELE, AGT, AGTR1, NOS3
positive regulation of molecular function (GO:0044093)	-	2.23	0.003	NOS2, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
calcium-mediated signaling (GO:0019722)	-	5.24	0.02	ATP1B1, SELE, AGT, NOS3, AGTR1
organic acid transport (GO:0015849)	NEW	4.93	0.044	ATP1B1, NOS2, AGT, NOS3, AGTR1
positive regulation of vasodilation (GO:0045909)	-	6.26	0.019	NOS2, AGT, NOS3
regulation of blood vessel endothelial cell migration (GO:0043535)	NEW	5.8	0.002	SELE, NOS3, AGT, NOS2
regulation of cholesterol esterification (GO:0010872)	-	7.43	0.016	AGT, AGTR1
positive regulation of cholesterol esterification (GO:0010873)	-	7.65	0.009	AGT, AGTR1
regulation of systemic arterial blood pressure by hormone (GO:0001990)	-	6.43	0.0	NOS3, AGT, ECE1, AGTR1
single-multicellular organism process (GO:0044707)	-	1.78	0.036	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, AGTR1, NOS3, UMOD
phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200)	-	5.38	0.046	NOS3, AGT, AGTR1
regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	-	7.16	0.025	AGT, AGTR1
relaxation of muscle (GO:0090075)	NEW	6.78	0.01	NOS3, AGT, ATP1B1
positive regulation of activation of JAK2 kinase activity (GO:0010535)	NEW	7.94	0.04	NOS2, AGT
low-density lipoprotein particle remodeling (GO:0034374)	-	7.33	0.002	NOS2, AGT, AGTR1
regulation of vasculature development (GO:1901342)	-	4.26	0.008	NOS3, AGT, ADD1, PTGIS
glutamine family amino acid catabolic process (GO:0009065)	-	6.55	0.011	NOS2, AGT, NOS3
positive regulation of protein serine/threonine kinase activity (GO:0071902)	NEW	4.06	0.026	NOS2, ADD1, SELE, AGT, AGTR1, NOS3
regulation of vasodilation (GO:0042312)	-	5.86	0.003	NOS2, AGT, NOS3, AGTR1
nitric oxide biosynthetic process (GO:0006809)	-	7.16	0.041	NOS2, NOS3
renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure (GO:0003072)	-	8.63	0.001	AGT, AGTR1
regulation of systemic arterial blood pressure (GO:0003073)	-	5.99	0.0	NOS3, AGT, ECE1, AGTR1
regulation of oxidoreductase activity (GO:0051341)	-	5.27	0.019	NOS2, AGT, NOS3, AGTR1
positive regulation of hydrolase activity (GO:0051345)	-	2.91	0.016	NOS2, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
regulation of cytokine production (GO:0001817)	-	3.4	0.007	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3, UMOD
cellular response to interleukin-6 (GO:0071354)	NEW	7.02	0.007	SELE, NOS2, PTGIS
cellular sodium ion homeostasis (GO:0006883)	-	6.84	0.035	AGT, ATP1B1
response to interleukin-6 (GO:0070741)	NEW	6.78	0.014	SELE, NOS2, PTGIS
regulation of platelet activation (GO:0010543)	NEW	6.26	0.046	NOS2, AGT, NOS3
regulation of molecular function (GO:0065009)	-	1.78	0.008	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, PTGIS, NOS3
regulation of biological quality (GO:0065008)	-	1.68	0.001	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, AGTR1, GNB3, NOS3, UMOD
regulation of tube size (GO:0035150)	-	4.79	0.013	NOS2, AGT, NOS3, AGTR1
response to cytokine (GO:0034097)	-	3.84	0.02	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, PTGIS, NOS3
smooth muscle adaptation (GO:0014805)	NEW	8.34	0.023	NOS3, AGT
regulation of catalytic activity (GO:0050790)	-	1.97	0.024	NOS2, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of blood vessel size (GO:0050880)	-	4.8	0.01	NOS2, AGT, NOS3, AGTR1
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.023	NOS2, AGTR1, ADD1, NOS3, ATP1B1, AGT, ECE1, PTGIS
acute inflammatory response (GO:0002526)	NEW	5.48	0.022	NOS3, AGT, NOS2, AGTR1
regulation of systemic arterial blood pressure by endothelin (GO:0003100)	-	8.12	0.011	NOS3, ECE1
regulation of hydrolase activity (GO:0051336)	-	2.53	0.008	NOS3, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1
response to decreased oxygen levels (GO:0036293)	-	4.09	0.034	NOS2, PTGIS, NOS3, ATP1B1, AGT, AGTR1
regulation of NAD(P)H oxidase activity (GO:0033860)	-	7.94	0.007	AGT, AGTR1
positive regulation of NAD(P)H oxidase activity (GO:0033864)	-	8.63	0.017	AGT, AGTR1
regulation of leukocyte activation (GO:0002694)	NEW	3.6	0.026	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
coagulation (GO:0050817)	NEW	4.51	0.039	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
negative regulation of protein maturation (GO:1903318)	NEW	6.17	0.029	SELE, NOS3, AGT, NOS2
positive regulation of lipase activity (GO:0060193)	-	5.54	0.032	SELE, AGT, NOS3, AGTR1
negative regulation of response to external stimulus (GO:0032102)	-	4.18	0.007	NOS2, PTGIS, SELE, AGT, AGTR1, NOS3
regulation of response to external stimulus (GO:0032101)	-	3.06	0.032	PTGIS, SELE, AGT, NOS3, AGTR1
response to hypoxia (GO:0001666)	-	4.13	0.032	NOS2, PTGIS, NOS3, ATP1B1, AGT, AGTR1
positive regulation of catalytic activity (GO:0043085)	-	2.4	0.001	NOS2, RGS5, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of cellular response to growth factor stimulus (GO:0090287)	NEW	4.29	0.041	SELE, NOS3, AGT, NOS2, AGTR1
regulation of lymphocyte activation (GO:0051249)	NEW	3.73	0.011	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
endocrine process (GO:0050886)	-	6.43	0.0	NOS3, AGT, ECE1, AGTR1
regulation of system process (GO:0044057)	-	3.53	0.0	NOS2, NOS3, ATP1B1, AGT, ECE1, AGTR1
negative regulation of protein processing (GO:0010955)	NEW	6.17	0.029	SELE, NOS3, AGT, NOS2
regulation of response to wounding (GO:1903034)	NEW	4.74	0.002	PTGIS, SELE, AGT, NOS3, AGTR1
negative regulation of response to wounding (GO:1903035)	NEW	5.54	0.004	SELE, NOS3, AGT, NOS2, PTGIS
regulation of sodium ion transport (GO:0002028)	-	5.4	0.009	NOS2, AGT, NOS3, ATP1B1
alpha-amino acid catabolic process (GO:1901606)	-	5.54	0.039	ADD1, NOS2, AGT, NOS3
multicellular organismal process (GO:0032501)	-	1.45	0.043	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, AGTR1, NOS3, UMOD
positive regulation of ion transport (GO:0043270)	NEW	4.36	0.036	ATP1B1, NOS3, AGT, NOS2, AGTR1
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	-	6.36	0.0	NOS3, AGT, ECE1, AGTR1
regulation of excretion (GO:0044062)	-	6.36	0.007	NOS3, AGT, AGTR1
positive regulation of developmental process (GO:0051094)	-	2.77	0.045	NOS2, AGTR1, ADD1, SELE, ECE1, AGT, PTGIS, GNB3, NOS3
regulation of blood vessel size by renin-angiotensin (GO:0002034)	-	8.63	0.001	AGT, AGTR1
positive regulation of cardiac muscle contraction (GO:0060452)	NEW	7.24	0.031	NOS3, AGT
positive regulation of guanylate cyclase activity (GO:0031284)	-	7.33	0.025	NOS2, NOS3
second-messenger-mediated signaling (GO:0019932)	-	4.65	0.0	NOS2, SELE, ATP1B1, AGT, AGTR1, NOS3
regulation of guanylate cyclase activity (GO:0031282)	-	7.16	0.03	NOS2, NOS3
regulation of cell activation (GO:0050865)	NEW	3.53	0.047	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, NOS3
leukocyte migration (GO:0050900)	-	4.19	0.005	NOS3, SELE, ATP1B1, AGT, AGTR1, UMOD
regulation of blood pressure (GO:0008217)	-	4.72	0.0	NOS2, NOS3, ECE1, AGT, ATP1B1, AGTR1, GNB3
nitric oxide metabolic process (GO:0046209)	-	7.02	0.031	NOS2, AGT, NOS3
response to interleukin-1 (GO:0070555)	-	5.07	0.032	SELE, AGT, NOS3, PTGIS
arginine catabolic process (GO:0006527)	-	7.53	0.013	NOS2, NOS3
regulation of angiogenesis (GO:0045765)	-	4.36	0.006	NOS3, AGT, ADD1, PTGIS
positive regulation of angiogenesis (GO:0045766)	-	4.93	0.045	SELE, NOS3, AGT, ADD1, PTGIS
positive regulation of macrophage derived foam cell differentiation (GO:0010744)	-	7.02	0.0	SELE, AGT, NOS3, AGTR1
regulation of renal sodium excretion (GO:0035813)	-	6.55	0.003	NOS3, AGT, AGTR1
regulation of macrophage derived foam cell differentiation (GO:0010743)	-	6.4	0.0	NOS3, AGT, NOS2, AGTR1
regulation of steroid metabolic process (GO:0019218)	-	5.42	0.047	NOS2, AGT, NOS3, AGTR1
signal release (GO:0023061)	NEW	4.65	0.014	ADD1, SELE, AGT, NOS3, AGTR1
regulation of hormone levels (GO:0010817)	-	3.56	0.001	NOS2, SELE, ATP1B1, AGT, ECE1, AGTR1, NOS3
nitric oxide mediated signal transduction (GO:0007263)	-	6.78	0.003	NOS2, AGT, NOS3
carboxylic acid transport (GO:0046942)	NEW	4.28	0.043	ATP1B1, NOS2, AGT, NOS3, AGTR1
regulation of cGMP biosynthetic process (GO:0030826)	-	6.64	0.013	NOS2, AGT, NOS3
regulation of purine nucleotide metabolic process (GO:1900542)	-	4.41	0.038	NOS2, RGS5, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
regulation of cGMP metabolic process (GO:0030823)	-	6.36	0.033	NOS2, AGT, NOS3
renin-angiotensin regulation of aldosterone production (GO:0002018)	-	8.34	0.003	AGT, AGTR1
regulation of calcium ion transport (GO:0051924)	-	4.38	0.041	NOS2, AGT, NOS3, ATP1B1, GNB3
positive regulation of phospholipase activity (GO:0010518)	-	5.76	0.018	SELE, AGT, NOS3, AGTR1
regulation of ion homeostasis (GO:2000021)	-	4.44	0.023	UMOD, NOS3, AGT, NOS2, AGTR1
regulation of nucleotide metabolic process (GO:0006140)	-	4.38	0.04	NOS2, RGS5, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
regulation of phospholipase activity (GO:0010517)	-	5.57	0.028	SELE, AGT, NOS3, AGTR1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	13	NOS2, AGTR1, RGS5, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, CYP3A5, UMOD
intracellular part (GO:0044424)	0.28	11	NOS2, RGS5, ADD1, SELE, ECE1, AGT, PTGIS, GNB3, NOS3, CYP3A5, UMOD
membrane (GO:0016020)	0.68	11	NOS3, AGTR1, RGS5, ADD1, SELE, ATP1B1, ECE1, PTGIS, GNB3, CYP3A5, UMOD
organelle (GO:0043226)	0.4	11	NOS2, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, CYP3A5, NOS3, GNB3, UMOD
membrane-bounded organelle (GO:0043227)	0.47	10	NOS2, ADD1, NOS3, ATP1B1, AGT, ECE1, PTGIS, CYP3A5, GNB3, UMOD
cytoplasmic part (GO:0044444)	0.82	9	NOS2, ADD1, SELE, ECE1, PTGIS, GNB3, NOS3, CYP3A5, UMOD
plasma membrane (GO:0005886)	1.39	9	NOS3, RGS5, ADD1, SELE, ATP1B1, ECE1, AGTR1, GNB3, UMOD
membrane part (GO:0044425)	0.95	8	NOS3, AGTR1, SELE, ATP1B1, ECE1, PTGIS, CYP3A5, UMOD
intracellular organelle (GO:0043229)	0.51	8	NOS2, ADD1, SELE, ECE1, PTGIS, CYP3A5, NOS3, UMOD
integral component of membrane (GO:0016021)	1.14	7	SELE, PTGIS, ATP1B1, ECE1, AGTR1, CYP3A5, UMOD
plasma membrane part (GO:0044459)	1.95	7	NOS3, AGTR1, SELE, ATP1B1, ECE1, PTGIS, UMOD
intracellular membrane-bounded organelle (GO:0043231)	0.6	7	NOS2, ADD1, NOS3, ECE1, PTGIS, CYP3A5, UMOD
intrinsic component of membrane (GO:0031224)	1.13	7	SELE, PTGIS, ATP1B1, ECE1, AGTR1, CYP3A5, UMOD
extracellular region part (GO:0044421)	1.57	7	SELE, ECE1, AGT, ATP1B1, PTGIS, GNB3, UMOD
intracellular organelle part (GO:0044446)	0.81	6	NOS3, ADD1, ECE1, PTGIS, CYP3A5, UMOD
cytoplasm (GO:0005737)	1.01	6	NOS2, RGS5, ADD1, NOS3, AGT, PTGIS
organelle part (GO:0044422)	0.79	6	NOS3, ADD1, ECE1, PTGIS, CYP3A5, UMOD
plasma membrane region (GO:0098590)	2.97	5	UMOD, SELE, ATP1B1, NOS3, PTGIS
extracellular vesicle (GO:1903561)	1.89	5	ATP1B1, GNB3, AGT, ECE1, UMOD
extracellular organelle (GO:0043230)	1.89	5	ATP1B1, GNB3, AGT, ECE1, UMOD
vesicle (GO:0031982)	1.64	5	ATP1B1, GNB3, AGT, UMOD, ECE1
membrane region (GO:0098589)	3.95	5	PTGIS, SELE, ATP1B1, NOS3, UMOD
membrane-bounded vesicle (GO:0031988)	1.71	5	ATP1B1, GNB3, AGT, UMOD, ECE1
membrane raft (GO:0045121)	4.18	5	UMOD, SELE, ATP1B1, NOS3, PTGIS
membrane microdomain (GO:0098857)	4.17	5	PTGIS, SELE, ATP1B1, NOS3, UMOD
extracellular exosome (GO:0070062)	1.89	5	ATP1B1, GNB3, AGT, ECE1, UMOD
cytoskeleton (GO:0005856)	2.55	4	ADD1, SELE, NOS3, NOS2
organelle membrane (GO:0031090)	1.97	4	CYP3A5, NOS3, ECE1, UMOD
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	4	ADD1, SELE, NOS3, NOS2
cytosol (GO:0005829)	1.68	4	ADD1, NOS2, NOS3, GNB3
caveola (GO:0005901)	5.55	4	SELE, ATP1B1, NOS3, PTGIS
non-membrane-bounded organelle (GO:0043228)	1.76	4	ADD1, SELE, NOS3, NOS2
plasma membrane raft (GO:0044853)	5.42	4	SELE, ATP1B1, NOS3, PTGIS
nucleus (GO:0005634)	1.07	4	ADD1, NOS2, NOS3, PTGIS
extracellular space (GO:0005615)	2.63	4	SELE, AGT, PTGIS, UMOD
bounding membrane of organelle (GO:0098588)	2.39	3	NOS3, ECE1, UMOD
perinuclear region of cytoplasm (GO:0048471)	3.35	3	SELE, NOS2, ECE1
intracellular (GO:0005622)	2.37	3	NOS2, ATP1B1, AGTR1
protein complex (GO:0043234)	1.51	2	ADD1, ATP1B1
Golgi apparatus (GO:0005794)	2.7	2	NOS3, UMOD
macromolecular complex (GO:0032991)	1.35	2	ADD1, ATP1B1
endoplasmic reticulum (GO:0005783)	2.56	2	CYP3A5, PTGIS
cortical cytoskeleton (GO:0030863)	5.58	2	SELE, NOS2
cytoplasmic vesicle (GO:0031410)	2.87	2	ECE1, UMOD
whole membrane (GO:0098805)	2.85	2	NOS3, ECE1
endoplasmic reticulum membrane (GO:0005789)	2.95	2	CYP3A5, PTGIS
endoplasmic reticulum part (GO:0044432)	2.73	2	CYP3A5, PTGIS
basolateral plasma membrane (GO:0016323)	4.56	2	ATP1B1, UMOD
cytoskeletal part (GO:0044430)	2.49	2	ADD1, UMOD
cell cortex part (GO:0044448)	5.01	2	SELE, NOS2
intracellular vesicle (GO:0097708)	2.86	2	ECE1, UMOD
extracellular region (GO:0005576)	2.18	2	AGT, UMOD
cell projection (GO:0042995)	2.47	2	GNB3, UMOD
cell junction (GO:0030054)	2.75	2	ADD1, ATP1B1
apical plasma membrane (GO:0016324)	4.13	2	ATP1B1, UMOD

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
apical plasma membrane (GO:0016324)	-	4.13	0.003	NOS2, SELE, ATP1B1, AGT, NOS3, UMOD
cell projection part (GO:0044463)	NEW	2.97	0.015	NOS3, ADD1, SELE, ATP1B1, AGT, AGTR1, GNB3, UMOD
organelle membrane (GO:0031090)	-	1.97	0.041	NOS2, AGTR1, SELE, ATP1B1, AGT, ECE1, PTGIS, CYP3A5, NOS3, GNB3, UMOD
synapse part (GO:0044456)	NEW	3.42	0.035	NOS2, ADD1, NOS3, AGT, AGTR1, GNB3
endoplasmic reticulum part (GO:0044432)	-	2.73	0.029	NOS2, SELE, AGTR1, NOS3, ATP1B1, AGT, PTGIS, CYP3A5
cortical cytoskeleton (GO:0030863)	-	5.58	0.0	ADD1, SELE, AGT, NOS2
intrinsic component of membrane (GO:0031224)	-	1.13	0.05	SELE, ECE1, AGTR1
membrane region (GO:0098589)	-	3.95	0.015	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, PTGIS, CYP3A5, NOS3, UMOD
endoplasmic reticulum membrane (GO:0005789)	-	2.95	0.031	NOS2, PTGIS, SELE, AGT, AGTR1, CYP3A5, NOS3
cytoplasmic vesicle part (GO:0044433)	NEW	3.41	0.014	NOS2, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
caveola (GO:0005901)	-	5.55	0.001	SELE, ATP1B1, NOS3, PTGIS
basolateral plasma membrane (GO:0016323)	-	4.56	0.003	ATP1B1, NOS2, AGT, NOS3, UMOD
Golgi lumen (GO:0005796)	NEW	5.28	0.003	SELE, NOS3, AGT, NOS2
postsynaptic density (GO:0014069)	NEW	4.77	0.001	ADD1, NOS2, AGT, NOS3, AGTR1
cell cortex part (GO:0044448)	-	5.01	0.007	ADD1, SELE, AGT, NOS2
vacuolar part (GO:0044437)	NEW	3.26	0.005	NOS2, NOS3, ATP1B1, AGT, ECE1, AGTR1
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.039	NOS2, ADD1, SELE, ECE1, AGT, AGTR1, GNB3, NOS3
extracellular matrix (GO:0031012)	NEW	3.81	0.041	SELE, NOS3, AGT, NOS2, ECE1
plasma membrane part (GO:0044459)	-	1.95	0.033	NOS2, AGTR1, ADD1, SELE, ATP1B1, AGT, ECE1, PTGIS, GNB3, NOS3, CYP3A5, UMOD
cell junction (GO:0030054)	-	2.75	0.048	NOS2, ADD1, SELE, ATP1B1, AGT, AGTR1, GNB3, NOS3
membrane raft (GO:0045121)	-	4.18	0.0	NOS3, AGTR1, SELE, ATP1B1, AGT, PTGIS, UMOD