Gene table of EPHB2 : EPH receptor B2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EPHB2	OMIM link	Number of associated genes	genes
603688	PROSTATE CANCER/BRAIN CANCER SUSCEPTIBILITY	ClinVar, OMIM	link to OMIM	1	EPHB2
176807	PROSTATE CANCER	HUMSAVAR	link to OMIM	15	PTEN, EPHB2, KLF6, AR, HIP1, CD82, ZFHX3, BRCA2, CDH1, CHEK2, MXI1, MAD1L1, HOXB13, MSR1, FGFR4

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Annotation of the gene EPHB2

Associated genes in ENSEMBL

ENSG00000133216

Associated proteins - SwissProt Accession ID

P29323

Associated PDB IDs

Cytogenetic Band

1p36.12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Axon guidance	hsa04360	5.63

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
L1CAM interactions	R-HSA-373760	6.19
EPH-ephrin mediated repulsion of cells	R-HSA-3928665	7.34
Ephrin signaling	R-HSA-3928664	8.73
EPHB-mediated forward signaling	R-HSA-3928662	7.62
Axon guidance	R-HSA-422475	3.93
EPH-Ephrin signaling	R-HSA-2682334	6.43
Developmental Biology	R-HSA-1266738	3.48

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
molecular transducer activity	GO:0060089	2.32
axon guidance receptor activity	GO:0008046	7.79
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
purine nucleoside binding	GO:0001883	2.22
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
transmembrane-ephrin receptor activity	GO:0005005	7.54
transmembrane signaling receptor activity	GO:0004888	2.57
nucleotide binding	GO:0000166	1.96
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
identical protein binding	GO:0042802	2.63
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
ephrin receptor activity	GO:0005003	6.79
transferase activity	GO:0016740	1.95
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32