Disease table of PROSTATE CANCER OMIM ID: 176807

Gene-disease associations table

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Gene	Associated with PROSTATE CANCER in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
AR	OMIM	HGNC link	Xq12	5	300068, 176807, 313200, 312300, PS300633
BRCA2	OMIM	HGNC link	13q13.1	8	PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
CD82	OMIM	HGNC link	11p11.2	1	176807
CDH1	OMIM	HGNC link	16q22.1	5	608089, 167000, 176807, 137215, 114480
CHEK2	OMIM, HUMSAVAR	HGNC link	22q12.1	4	PS151623, 176807, 259500, 114480
EPHB2	HUMSAVAR	HGNC link	1p36.12	2	603688, 176807
FGFR4	HUMSAVAR	HGNC link	5q35.2	1	176807
HIP1	OMIM	HGNC link	7q11.23	1	176807
HOXB13	HUMSAVAR	HGNC link	17q21.32	1	176807
KLF6	OMIM	HGNC link	10p15.2	2	613659, 176807

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Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
16q22	2	ZFHX3, CDH1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
10q2	2	PTEN, MXI1
16q2	2	ZFHX3, CDH1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
10q	2	PTEN, MXI1
16q	2	ZFHX3, CDH1

By chromosome

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Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
7	2	MAD1L1, HIP1
10	3	PTEN, KLF6, MXI1
16	2	ZFHX3, CDH1

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Transcription Factors (TF) annotation from TRRUST

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TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
ZFHX3	YES	4	CDKN1A, MYB, AFP, MUC5AC	0
KLF6	YES	16	NOS2, DAPK2, ATF3, PTTG1, CCND1, PMAIP1, CDKN1A, CDH1, ASAH1, TFPI2, MMP9, CERS2, KRT12, PSG5, LTC4S, TXNIP	1	CDH1
AR	YES	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	2	PTEN, CDH1
MXI1	YES	2	MYC, MYCN	0
HOXB13	YES	2	AR, TCF4	1	AR
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	4	AR, BRCA2, PTEN, CDH1
WT1	NO	51	MYC, NR5A1, CTGF, AR, CD97, TBXA2R, MYB, EGFR, HBEGF, DNMT3A, ITGAX, CCNE1, ABCB1, EREG, THBS1, CIAO1, NOV, NDRG2, SMAD3, CD14, SNAI2, NPHS1, CDKN1A, PDGFA, TERT, IRF8, VDR, PODXL, CDH1, STIM1, JUN, CKM, AMH, CYP19A1, VEGFA, VEGFB, ODC1, ETS1, KLK3, JUNB, BCL2, IGF1R, PAX2, IGF2, IL2RB, MYCN, IGF1, SRY, UBE2I, CX3CL1, CAMP	2	AR, CDH1
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	AR, PTEN
YBX1	NO	29	AR, RAD9A, MET, ANAPC4, CKS2, AGT, EGFR, SKP2, TYMS, FAS, SLC6A4, CXCR4, CCNC, ERBB2, ERBB3, RBBP8, E2F1, CDC20, CDKN3, TOP2A, CDH1, SUMO1, MMP2, KPNA2, ABCB1, MMP13, CCNB1, MNAT1, MYCN	2	AR, CDH1
HIF1A	NO	80	RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A	2	AR, CDH1

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regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
EPHB2	YES	2	REL, BTF3	0
BRCA2	YES	11	ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF1	0
PTEN	YES	15	SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF	1	AR
MAD1L1	YES	3	CEBPB, TP53, CEBPA	0
HIP1	YES	1	TFAP2A	0
CD82	YES	7	ATF3, HDAC1, TFAP2A, JUN, TP53, MITF, JUNB	0
ZFHX3	YES	1	ESR1	0
KLF6	YES	1	NR1I2	0
AR	YES	37	PIAS1, SOX9, TCF21, PURA, TRIM24, URI1, NCOR1, SP1, NKX3-1, POU2F1, EGR1, PA2G4, HOXB13, CREB1, NCOR2, KHDRBS1, NCOA2, YBX1, FOXO3, HDAC1, WT1, ESR1, LEF1, IFI16, ETV1, AES, RELA, NCOA4, NFKB1, E2F1, FOXH1, SREBF1, JUN, BRD7, NSD1, ZEB1, HIF1A	1	HOXB13
CDH1	YES	49	AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A	2	AR, KLF6

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Interactions from BIOGRID - physical

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Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
BRCA2	CHEK2	Yes	7	ATM, KAT2B, ATR, PLK1, TP53, BRCA1, CHEK2
PTEN	AR	Yes	17	KAT2B, USP10, CALM1, AKT1, AR, PARK7, NCOA3, USP7, PPP1CA, HSP90AA1, CAV1, HSPA1A, CTNNB1, UBE2I, ETS1, BMI1, STUB1
PTEN	CDH1	Yes	9	HSP90AA1, HSPA8, CDC27, CDH1, JUP, PPP1CA, CTNNB1, HSPD1, YES1
EPHB2	PTEN	No	1	YES1
EPHB2	HIP1	No	1	ITSN1
EPHB2	AR	No	2	SRC, KDM4A
EPHB2	CDH1	No	2	SRC, YES1
BRCA2	PTEN	No	3	KAT2B, NEDD4, TP53
BRCA2	MAD1L1	No	1	VPS28
BRCA2	KLF6	No	1	SP1

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Direct interactions graph
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Interactions from BIOGRID - genetic

Interactions from STRING

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Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
BRCA2	AR	Yes	activation, binding	3	BRCA1, SMAD3, TP53
BRCA2	CHEK2	Yes	binding, ptmod	7	ATR, TREX1, CHEK1, PLK1, TP53, H2AFX, BRCA1
PTEN	AR	Yes	activation	36	KAT2B, PRDX1, SMAD4, CAV1, EGFR, HDAC9, FOS, SP1, MAPK8, INSR, PARK7, NCOA3, PIK3CA, SMAD3, MAPK14, CDKN1A, ESR1, CDH1, JUN, IL8, TP53, AKT1, SRC, VEGFA, FOXO3, EGR1, CDC6, ZBTB16, EZH2, PIK3R1, SMARCA4, UBC, UBE2I, CCND1, PPARG, IGF1R
PTEN	CDH1	Yes	activation, binding	43	AR, FOXM1, SNAI1, VCL, SMAD4, CAV1, CDX1, EGFR, HDAC9, FOS, IGF2BP1, DLG1, NRP2, SUMO1, CCND1, PIK3CA, MTA1, SMAD3, TGFB1, TGM2, TBX3, SMARCA4, IL8, RPS6KB1, JUN, TP53, AKT1, SRC, MTA3, FOXO3, RPTOR, NOTCH1, BCL2, CDC6, IGF1R, EZH2, IGF2, PIK3R1, CDX2, UBC, LEP, PPARG, RAC3
CD82	CDH1	Yes	binding	5	MET, UBC, EGFR, PRKCA, TP53
KLF6	CDH1	Yes	expression, binding	6	CCND1, RPS6KB1, UBC, JUN, TGFB1, PPARG
AR	CDH1	Yes	expression, activation, binding	47	AKT1, SOX9, MET, TP53, SMAD4, CAV1, FOXA2, PIK3CA, EGFR, CALR, HDAC9, FOS, SKP2, MDM2, SPDEF, EP300, CCND1, PIK3R1, GLI2, ERBB2, SMAD3, CTNNB1, ERBB3, FOXO3, VHL, ZEB1, ESR2, HDAC1, IL8, JUN, MACROD1, PTEN, SRC, NFKB1, SMARCA4, FHL2, STAT3, CDC6, IGF1R, MAPK1, EZH2, RB1, IGF1, UBC, MYC, PPARG, FOXA1
AR	HOXB13	Yes	activation, binding	3	YY1, EZH2, KLK3
EPHB2	PTEN	No	-	7	PHLPP1, PHLPP2, PIK3CA, UBC, PIK3R1, SRC, EPHB1
EPHB2	MAD1L1	No	-	1	UBC

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Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
BRCA2	AR	No	-	1	KDM1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

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KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Endometrial cancer	hsa05213	6.81	2	PTEN, CDH1
p53 signaling pathway	hsa04115	6.56	3	CHEK2, CD82, PTEN
Melanoma	hsa05218	6.56	2	PTEN, CDH1
Prostate cancer	hsa05215	6.11	2	AR, PTEN
Cell cycle	hsa04110	5.68	2	CHEK2, MAD1L1
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	2	ZFHX3, FGFR4
Rap1 signaling pathway	hsa04015	4.97	2	FGFR4, CDH1
PI3K-Akt signaling pathway	hsa04151	4.21	2	FGFR4, PTEN
Pathways in cancer	hsa05200	3.98	4	AR, BRCA2, PTEN, CDH1

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
p53 signaling pathway (hsa04115)	-	6.56	0.015	CHEK2, CD82, PTEN
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.017	CHEK2, FGFR4, PTEN, CDH1, ZFHX3
Cell growth and death	NEW	4.41	0.005	AR, CD82, CDH1, MXI1, PTEN, CHEK2, MAD1L1
Cancers: Overview	NEW	2.72	0.049	AR, BRCA2, EPHB2, CDH1, MXI1, FGFR4, MAD1L1, PTEN, CD82, CHEK2, HIP1
Cellular Processes	NEW	2.22	0.007	ZFHX3, EPHB2, AR, HOXB13, HIP1, CDH1, MSR1, MXI1, FGFR4, PTEN, CD82, CHEK2, MAD1L1

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REACTOME pathways annotation: shared terms (no NET-GE enrichment)

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REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	2	FGFR4, PTEN
PIP3 activates AKT signaling	R-HSA-1257604	6.37	2	FGFR4, PTEN
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	2	FGFR4, PTEN
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	2	FGFR4, PTEN
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	2	FGFR4, PTEN
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	2	FGFR4, PTEN
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	2	FGFR4, PTEN
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	2	FGFR4, PTEN
PI3K/AKT activation	R-HSA-198203	6.32	2	FGFR4, PTEN
GAB1 signalosome	R-HSA-180292	6.31	2	FGFR4, PTEN

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GO - molecular function annotation: shared terms / NET-GE enrichment

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GO	IC	Number of genes with the same GO	Genes
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	FGFR4, EPHB2
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	FGFR4, EPHB2
beta-catenin binding (GO:0008013)	5.3	2	AR, CDH1
protein tyrosine kinase activity (GO:0004713)	4.54	2	FGFR4, EPHB2
protein kinase binding (GO:0019901)	3.44	2	CHEK2, PTEN
kinase binding (GO:0019900)	3.32	2	CHEK2, PTEN
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	AR, ZFHX3
protein kinase activity (GO:0004672)	3.27	3	CHEK2, FGFR4, EPHB2
lipid binding (GO:0008289)	3.26	3	AR, HIP1, PTEN
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	AR, ZFHX3

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
calcium channel regulator activity (GO:0005246)	NEW	6.15	0.017	PTEN, EPHB2, CD82
frizzled binding (GO:0005109)	NEW	6.1	0.009	PTEN, CDH1, EPHB2
transmembrane receptor protein kinase activity (GO:0019199)	-	5.32	0.005	FGFR4, PTEN, CDH1, EPHB2
growth factor binding (GO:0019838)	NEW	4.89	0.04	AR, FGFR4, PTEN, CDH1
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.038	CHEK2, AR, FGFR4, PTEN, CDH1
transcription corepressor activity (GO:0003714)	NEW	4.33	0.047	MXI1, CHEK2, AR, PTEN, CDH1
protein heterodimerization activity (GO:0046982)	NEW	3.64	0.0	AR, BRCA2, EPHB2, CDH1, MAD1L1, PTEN, CD82, CHEK2, HIP1
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.023	AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.021	AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
regulatory region DNA binding (GO:0000975)	-	3.03	0.023	AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1

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GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
dendritic spine morphogenesis (GO:0060997)	7.43	2	PTEN, EPHB2
negative regulation of DNA-dependent DNA replication (GO:2000104)	6.96	2	CHEK2, BRCA2
dendritic spine organization (GO:0097061)	6.9	2	PTEN, EPHB2
central nervous system neuron axonogenesis (GO:0021955)	6.51	2	PTEN, EPHB2
negative regulation of DNA replication (GO:0008156)	6.17	2	CHEK2, BRCA2
cellular response to alcohol (GO:0097306)	6.07	2	KLF6, CDH1
regulation of DNA-dependent DNA replication (GO:0090329)	5.97	2	CHEK2, BRCA2
response to gamma radiation (GO:0010332)	5.78	2	CHEK2, BRCA2
synapse assembly (GO:0007416)	5.55	2	PTEN, CDH1
cell aging (GO:0007569)	5.54	2	CHEK2, BRCA2

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
regulation of sodium-dependent phosphate transport (GO:2000118)	NEW	8.63	0.022	AR, CDH1
positive regulation of integrin biosynthetic process (GO:0045726)	NEW	8.63	0.022	AR, CDH1
epithelial cell maturation involved in prostate gland development (GO:0060743)	NEW	8.63	0.03	AR, HOXB13
dendritic spine morphogenesis (GO:0060997)	-	7.43	0.014	PTEN, EPHB2
neurotrophin TRK receptor signaling pathway (GO:0048011)	NEW	6.96	0.029	EPHB2, AR, CD82, CDH1, PTEN, FGFR4
dendritic spine organization (GO:0097061)	-	6.9	0.04	PTEN, EPHB2
neurotrophin signaling pathway (GO:0038179)	NEW	6.55	0.035	EPHB2, AR, CD82, CDH1, PTEN, FGFR4
sex differentiation (GO:0007548)	NEW	6.33	0.018	AR, PTEN, CDH1
positive regulation of synapse assembly (GO:0051965)	NEW	5.62	0.042	AR, CDH1, EPHB2
cell aging (GO:0007569)	-	5.54	0.0	AR, CHEK2, BRCA2, PTEN, CDH1

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GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
cytoplasmic side of plasma membrane (GO:0009898)	6.0	2	PTEN, CDH1
cytoplasmic side of membrane (GO:0098562)	5.81	2	PTEN, CDH1
PML body (GO:0016605)	5.24	2	CHEK2, PTEN
chromosome, telomeric region (GO:0000781)	4.9	2	CHEK2, BRCA2
actin cytoskeleton (GO:0015629)	4.39	2	MAD1L1, CDH1
side of membrane (GO:0098552)	4.22	2	PTEN, CDH1
chromosomal region (GO:0098687)	4.19	3	CHEK2, BRCA2, MAD1L1
transcription factor complex (GO:0005667)	4.1	2	ZFHX3, HOXB13
nuclear body (GO:0016604)	3.94	3	CHEK2, ZFHX3, PTEN
cell-cell junction (GO:0005911)	3.85	2	FGFR4, CDH1

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
Schmidt-Lanterman incisure (GO:0043220)	NEW	7.32	0.004	PTEN, CDH1
inclusion body (GO:0016234)	NEW	5.55	0.011	AR, PTEN, CDH1
axon (GO:0030424)	NEW	4.15	0.021	AR, PTEN, CDH1, EPHB2, CD82
nuclear chromosome part (GO:0044454)	-	3.67	0.0	AR, BRCA2, KLF6, HOXB13, CDH1, PTEN, MAD1L1
chromosomal part (GO:0044427)	-	3.18	0.026	AR, BRCA2, KLF6, HOXB13, CDH1, PTEN, MAD1L1
nucleolus (GO:0005730)	-	3.06	0.013	AR, BRCA2, PTEN, CDH1, MXI1, KLF6, CHEK2, MAD1L1
cytoplasmic vesicle (GO:0031410)	-	2.87	0.007	AR, BRCA2, CD82, CDH1, MSR1, MXI1, HIP1, PTEN, EPHB2
cytoskeletal part (GO:0044430)	-	2.49	0.044	EPHB2, BRCA2, KLF6, AR, CDH1, MXI1, HIP1, PTEN, CHEK2, MAD1L1
vesicle (GO:0031982)	-	1.64	0.006	AR, BRCA2, EPHB2, HOXB13, HIP1, CDH1, MSR1, MXI1, PTEN, FGFR4, KLF6, CD82, CHEK2, MAD1L1
protein complex (GO:0043234)	-	1.51	0.001	ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, MXI1, FGFR4, PTEN, HIP1, KLF6, CD82, CHEK2, MAD1L1

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