Disease table of PROSTATE CANCER OMIM ID: 176807

Gene-disease associations table

GeneAssociated with PROSTATE CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EPHB2HUMSAVARHGNC link1p36.122603688, 176807
BRCA2OMIMHGNC link13q13.18PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
PTENOMIM, HUMSAVARHGNC link10q23.3110276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
MAD1L1OMIMHGNC link7p22.31176807
HIP1OMIMHGNC link7q11.231176807
CD82OMIMHGNC link11p11.21176807
ZFHX3OMIMHGNC link16q22.31176807
KLF6OMIMHGNC link10p15.22613659, 176807
AROMIMHGNC linkXq125300068, 176807, 313200, 312300, PS300633
MXI1OMIM, HUMSAVARHGNC link10q25.21176807
CDH1OMIMHGNC link16q22.15608089, 167000, 176807, 137215, 114480
FGFR4HUMSAVARHGNC link5q35.21176807
MSR1OMIMHGNC link8p222614266, 176807
CHEK2OMIM, HUMSAVARHGNC link22q12.14PS151623, 176807, 259500, 114480
HOXB13HUMSAVARHGNC link17q21.321176807

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
16q222ZFHX3, CDH1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
16q22ZFHX3, CDH1
10q22PTEN, MXI1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
10q2PTEN, MXI1
16q2ZFHX3, CDH1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
103PTEN, KLF6, MXI1
162ZFHX3, CDH1
72MAD1L1, HIP1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ZFHX3YES4CDKN1A, MYB, AFP, MUC5AC0
KLF6YES16NOS2, DAPK2, ATF3, PTTG1, CCND1, PMAIP1, CDKN1A, CDH1, ASAH1, TFPI2, MMP9, CERS2, KRT12, PSG5, LTC4S, TXNIP1CDH1
ARYES83UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA12PTEN, CDH1
MXI1YES2MYC, MYCN0
HOXB13YES2AR, TCF41AR
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC64AR, BRCA2, PTEN, CDH1
WT1NO51MYC, NR5A1, CTGF, AR, CD97, TBXA2R, MYB, EGFR, HBEGF, DNMT3A, ITGAX, CCNE1, ABCB1, EREG, THBS1, CIAO1, NOV, NDRG2, SMAD3, CD14, SNAI2, NPHS1, CDKN1A, PDGFA, TERT, IRF8, VDR, PODXL, CDH1, STIM1, JUN, CKM, AMH, CYP19A1, VEGFA, VEGFB, ODC1, ETS1, KLK3, JUNB, BCL2, IGF1R, PAX2, IGF2, IL2RB, MYCN, IGF1, SRY, UBE2I, CX3CL1, CAMP2AR, CDH1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12AR, PTEN
YBX1NO29AR, RAD9A, MET, ANAPC4, CKS2, AGT, EGFR, SKP2, TYMS, FAS, SLC6A4, CXCR4, CCNC, ERBB2, ERBB3, RBBP8, E2F1, CDC20, CDKN3, TOP2A, CDH1, SUMO1, MMP2, KPNA2, ABCB1, MMP13, CCNB1, MNAT1, MYCN2AR, CDH1
HIF1ANO80RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A2AR, CDH1
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2AR, PTEN
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC3AR, MSR1, CD82
PARP1NO25FN1, SNAI1, IFNAR1, IFNG, VIM, SERPINE1, TERF2, TCF4, THBD, FOXO1, E2F1, CDKN1A, SMARCB1, CDH1, SH3BP2, FBN1, IL10, RELA, NFKB1, CXCL1, BRCA2, BCL2, HTR1A, JUN, SERPINF12BRCA2, CDH1
ZEB1NO12EPCAM, GRHL2, BCL6, COL4A3, AR, LAMC2, CDH1, SPRR1B, CXADR, MUC1, ITGB4, PKP32AR, CDH1
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING15CHEK2, BRCA2, PTEN, MAD1L1, CD82
HDAC1NO64NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B4AR, BRCA2, CD82, CDH1
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122PTEN, CDH1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC64AR, BRCA2, PTEN, CDH1
ESR1NO68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B3AR, ZFHX3, CDH1
EZH2NO31PCNA, SFRP1, ADRB2, TWIST1, SNAI2, CDKN2B, CDKN2A, APC, RUNX3, PIP5K1C, CCNE1, DACT3, HOXB13, ALDH1A1, BRCA1, FOXC1, CDKN1A, VDR, HDAC1, RPLP0, CDH1, SATB1, TP53, AXL, ADAMTS1, SSTR1, FBXO32, MMP2, PEBP1, CIITA, CCND12HOXB13, CDH1
CEBPANO50FN1, PRL, CXCR2, VLDLR, SLC2A4, TLR9, S100A9, CSF3R, MSR1, CSF1, AFP, ICAM1, SFTPD, ITGAX, INSR, HAMP, ELANE, STAR, SOCS3, DEFA1, CSF2RA, ID1, CYP3A4, SAA1, HOMER3, IGF1, GAPDH, PCK1, SLC10A1, CD163, SPP1, IL10, DEFA3, PCK2, F9, MAD1L1, SERPINC1, CDK2, BCL2, IL3, HSPA4, ALB, IGF2, IL5, IL6, HSD17B11, CRMP1, MYC, LEP, PRTN32MSR1, MAD1L1
TFAP2ANO69SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH14HIP1, PTEN, CDH1, CD82
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF12PTEN, CDH1
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B2AR, CHEK2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
EPHB2YES2REL, BTF30
BRCA2YES11ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF10
PTENYES15SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF1AR
MAD1L1YES3CEBPB, TP53, CEBPA0
HIP1YES1TFAP2A0
CD82YES7ATF3, HDAC1, TFAP2A, JUN, TP53, MITF, JUNB0
ZFHX3YES1ESR10
KLF6YES1NR1I20
ARYES37PIAS1, SOX9, TCF21, PURA, TRIM24, URI1, NCOR1, SP1, NKX3-1, POU2F1, EGR1, PA2G4, HOXB13, CREB1, NCOR2, KHDRBS1, NCOA2, YBX1, FOXO3, HDAC1, WT1, ESR1, LEF1, IFI16, ETV1, AES, RELA, NCOA4, NFKB1, E2F1, FOXH1, SREBF1, JUN, BRD7, NSD1, ZEB1, HIF1A1HOXB13
CDH1YES49AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A2AR, KLF6
FGFR4YES1IKZF10
MSR1YES4SPI1, JUN, CEBPA, ETS20
CHEK2YES2E2F1, TP530
HOXB13YES3HDAC4, EZH2, YY10
CCND1NO62POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX62AR, KLF6
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING13AR, ZFHX3, KLF6
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
EPHB2PTENNo1YES1
EPHB2HIP1No1ITSN1
EPHB2ARNo2SRC, KDM4A
EPHB2CDH1No2SRC, YES1
BRCA2PTENNo3KAT2B, NEDD4, TP53
BRCA2MAD1L1No1VPS28
BRCA2KLF6No1SP1
BRCA2ARNo5SP1, KAT2B, BRCA1, SMAD3, FLNA
BRCA2MXI1No2BUB1B, SMC3
BRCA2CHEK2Yes7ATM, KAT2B, ATR, PLK1, TP53, BRCA1, CHEK2
PTENMAD1L1No3UBC, FLNB, CDC27
PTENHIP1No1CASP8
PTENZFHX3No1ELAVL1
PTENARYes17KAT2B, USP10, CALM1, AKT1, AR, PARK7, NCOA3, USP7, PPP1CA, HSP90AA1, CAV1, HSPA1A, CTNNB1, UBE2I, ETS1, BMI1, STUB1
PTENCDH1Yes9HSP90AA1, HSPA8, CDC27, CDH1, JUP, PPP1CA, CTNNB1, HSPD1, YES1
PTENFGFR4No1OSGIN1
PTENMSR1No1HSPA1A
PTENCHEK2No5KAT2B, IL24, ELAVL1, BEX1, TP53
MAD1L1HIP1No1NTRK1
MAD1L1ZFHX3No1NINL
MAD1L1ARNo3HDAC1, SIN3A, NONO
MAD1L1MXI1No1CDC20
MAD1L1CDH1No3HDAC1, HDAC2, CDC27
MAD1L1CHEK2No1RNF8
HIP1ARNo1REL
CD82ARNo1EGFR
CD82CDH1No1EGFR
ZFHX3ARNo2STAT3, PIAS3
ZFHX3MXI1No1KRT40
ZFHX3CHEK2No1ELAVL1
KLF6ARNo5SP1, HDAC3, NR0B2, E2F1, LCOR
KLF6MXI1No1APP
KLF6CDH1No2KLF4, E2F1
KLF6CHEK2No1APP
ARMXI1No1SIN3B
ARCDH1No15HSP90AA1, RNF2, CTNNB1, MDM2, EP300, HDAC1, PPP1CA, PTEN, SKP2, EGFR, SRC, E2F1, GSK3B, CREBBP, XRCC5
ARFGFR4No2CDK9, RNF20
ARMSR1No1HSPA1A
ARCHEK2No15KAT2B, VHL, LATS2, VCP, SIAH2, DAPK3, MAPK1, PRKDC, RCHY1, RB1, MDM2, AATF, BRCA1, RNF20, SIRT1
ARHOXB13No3EED, POU2F1, RNF2
MXI1CHEK2No1APP
CDH1CHEK2No1MDM2
CDH1HOXB13No1RNF2
FGFR4CHEK2No5DIRAS3, PSMC3IP, RNF20, FAM84B, WHSC1L1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
EPHB2PTENNo-7PHLPP1, PHLPP2, PIK3CA, UBC, PIK3R1, SRC, EPHB1
EPHB2MAD1L1No-1UBC
EPHB2CD82No-1UBC
EPHB2KLF6No-1UBC
EPHB2ARNo-6HRAS, PIK3CA, UBC, PIK3R1, SARS, SRC
EPHB2CDH1No-13RAC1, NUMB, TIAM1, RGS3, PIK3CA, UBC, PIK3R1, CDC42, ABL1, SRC, FYN, EFNA1, YES1
EPHB2FGFR4No-8EFNA2, PHLPP1, CRK, PHLPP2, EFNA5, EFNA4, UBC, EFNA1
EPHB2CHEK2No-1UBC
BRCA2PTENNo-3AR, SMAD3, TP53
BRCA2MAD1L1No-4AURKB, BUB1B, TP53, PLK1
BRCA2CD82No-1TP53
BRCA2ARYesactivation, binding3BRCA1, SMAD3, TP53
BRCA2CDH1No-5TP53, SNAI2, SMAD3, STAT5A, AR
BRCA2CHEK2Yesbinding, ptmod7ATR, TREX1, CHEK1, PLK1, TP53, H2AFX, BRCA1
BRCA2HOXB13No-1AR
PTENMAD1L1No-3UBC, BIRC5, TP53
PTENCD82No-6TIMP1, ESR1, CDH1, TP53, EGFR, UBC
PTENZFHX3No-2PDGFRB, SUMO1
PTENKLF6No-10SP1, KAT2B, CDKN1A, CCND1, JUN, CDH1, UBC, RPS6KB1, TGFB1, PPARG
PTENARYesactivation36KAT2B, PRDX1, SMAD4, CAV1, EGFR, HDAC9, FOS, SP1, MAPK8, INSR, PARK7, NCOA3, PIK3CA, SMAD3, MAPK14, CDKN1A, ESR1, CDH1, JUN, IL8, TP53, AKT1, SRC, VEGFA, FOXO3, EGR1, CDC6, ZBTB16, EZH2, PIK3R1, SMARCA4, UBC, UBE2I, CCND1, PPARG, IGF1R
PTENCDH1Yesactivation, binding43AR, FOXM1, SNAI1, VCL, SMAD4, CAV1, CDX1, EGFR, HDAC9, FOS, IGF2BP1, DLG1, NRP2, SUMO1, CCND1, PIK3CA, MTA1, SMAD3, TGFB1, TGM2, TBX3, SMARCA4, IL8, RPS6KB1, JUN, TP53, AKT1, SRC, MTA3, FOXO3, RPTOR, NOTCH1, BCL2, CDC6, IGF1R, EZH2, IGF2, PIK3R1, CDX2, UBC, LEP, PPARG, RAC3
PTENFGFR4No-13GRB2, PHLPP1, CBL, SOS1, INS, PHLPP2, IKZF1, NEDD4, UBC, PDGFB, VEGFA, SHC1, CSF1
PTENCHEK2No-6KAT2B, CDKN1A, FOXM1, PLK3, TP53, UBC
PTENHOXB13No-2AR, EZH2
MAD1L1CD82No-2UBC, TP53
MAD1L1KLF6No-1UBC
MAD1L1ARNo-2UBC, TP53
MAD1L1MXI1No-1MAX
MAD1L1CDH1No-4UBC, SMAD2, TP53, MAD2L2
MAD1L1FGFR4No-1UBC
MAD1L1CHEK2No-3UBC, TP53, PLK1
CD82KLF6No-3UBC, ATF3, CDH1
CD82ARNo-8ATF3, ESR1, MET, CDH1, UBC, TP53, EGFR, HBEGF
CD82CDH1Yesbinding5MET, UBC, EGFR, PRKCA, TP53
CD82FGFR4No-1UBC
CD82CHEK2No-2UBC, TP53
ZFHX3CDH1No-1SUMO1
KLF6ARNo-10SP1, KAT2B, CDKN1A, ATF3, CCND1, JUN, CDH1, HDAC3, UBC, PPARG
KLF6CDH1Yesexpression, binding6CCND1, RPS6KB1, UBC, JUN, TGFB1, PPARG
KLF6FGFR4No-1UBC
KLF6CHEK2No-3KAT2B, UBC, CDKN1A
ARMXI1No-2VHL, MYC
ARCDH1Yesexpression, activation, binding47AKT1, SOX9, MET, TP53, SMAD4, CAV1, FOXA2, PIK3CA, EGFR, CALR, HDAC9, FOS, SKP2, MDM2, SPDEF, EP300, CCND1, PIK3R1, GLI2, ERBB2, SMAD3, CTNNB1, ERBB3, FOXO3, VHL, ZEB1, ESR2, HDAC1, IL8, JUN, MACROD1, PTEN, SRC, NFKB1, SMARCA4, FHL2, STAT3, CDC6, IGF1R, MAPK1, EZH2, RB1, IGF1, UBC, MYC, PPARG, FOXA1
ARFGFR4No-5UBC, CDK9, VEGFA, IGF1, MDM2
ARMSR1No-2CALR, HSP90B1
ARCHEK2No-10KAT2B, VHL, CDKN1A, BRCA2, MDM2, TP53, RB1, RCHY1, UBC, BRCA1
ARHOXB13Yesactivation, binding3YY1, EZH2, KLK3
MXI1CDH1No-2VHL, MYC
MXI1CHEK2No-1VHL
CDH1FGFR4No-9HGF, FGF13, EGF, MMP14, MDM2, IGF1, UBC, FGF2, EFNA1
CDH1MSR1No-1CALR
CDH1CHEK2No-6VHL, FOXM1, MDM2, TP53, RB1, UBC
CDH1HOXB13No-2AR, EZH2
FGFR4CHEK2No-2UBC, MDM2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
BRCA2ARNo-1KDM1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.984AR, BRCA2, PTEN, CDH1
p53 signaling pathwayhsa041156.563CHEK2, CD82, PTEN
Melanomahsa052186.562PTEN, CDH1
Endometrial cancerhsa052136.812PTEN, CDH1
Cell cyclehsa041105.682CHEK2, MAD1L1
Signaling pathways regulating pluripotency of stem cellshsa045505.62ZFHX3, FGFR4
Prostate cancerhsa052156.112AR, PTEN
Rap1 signaling pathwayhsa040154.972FGFR4, CDH1
PI3K-Akt signaling pathwayhsa041514.212FGFR4, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
Cancers: OverviewNEW2.720.049AR, BRCA2, EPHB2, CDH1, MXI1, FGFR4, MAD1L1, PTEN, CD82, CHEK2, HIP1
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.017CHEK2, FGFR4, PTEN, CDH1, ZFHX3
Cell growth and deathNEW4.410.005AR, CD82, CDH1, MXI1, PTEN, CHEK2, MAD1L1
Cellular ProcessesNEW2.220.007ZFHX3, EPHB2, AR, HOXB13, HIP1, CDH1, MSR1, MXI1, FGFR4, PTEN, CD82, CHEK2, MAD1L1
p53 signaling pathway (hsa04115) -6.560.015CHEK2, CD82, PTEN
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785AR, FGFR4, PTEN, CDH1, MAD1L1
Cell CycleR-HSA-16401703.893CHEK2, BRCA2, MAD1L1
RHO GTPase EffectorsR-HSA-1952584.943AR, CDH1, MAD1L1
Immune SystemR-HSA-1682562.373FGFR4, PTEN, CDH1
Signaling by Rho GTPasesR-HSA-1943154.433AR, MAD1L1, CDH1
Adaptive Immune SystemR-HSA-12802183.193FGFR4, PTEN, CDH1
PI3K/AKT activationR-HSA-1982036.322FGFR4, PTEN
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622FGFR4, PTEN
Downstream signal transductionR-HSA-1867634.652FGFR4, PTEN
GAB1 signalosomeR-HSA-1802926.312FGFR4, PTEN
Signaling by ERBB4R-HSA-12363944.72FGFR4, PTEN
DiseaseR-HSA-16436853.332FGFR4, PTEN
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952FGFR4, PTEN
Downstream signaling of activated FGFR1R-HSA-56546874.712FGFR4, PTEN
PIP3 activates AKT signalingR-HSA-12576046.372FGFR4, PTEN
Generic Transcription PathwayR-HSA-2124363.862AR, PTEN
Gene ExpressionR-HSA-741602.722AR, PTEN
PI-3K cascade:FGFR1R-HSA-56546896.372FGFR4, PTEN
Cell Cycle CheckpointsR-HSA-696205.642CHEK2, MAD1L1
Developmental BiologyR-HSA-12667383.482FGFR4, EPHB2
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592FGFR4, PTEN
Downstream signaling of activated FGFR3R-HSA-56547084.712FGFR4, PTEN
Signaling by FGFR4R-HSA-56547434.692FGFR4, PTEN
Signaling by FGFR3R-HSA-56547414.692FGFR4, PTEN
Signaling by FGFRR-HSA-1902364.672FGFR4, PTEN
PI3K/AKT Signaling in CancerR-HSA-22195286.562FGFR4, PTEN
Diseases of signal transductionR-HSA-56632024.892FGFR4, PTEN
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032FGFR4, PTEN
Innate Immune SystemR-HSA-1682493.172FGFR4, PTEN
Signaling by SCF-KITR-HSA-14335574.732FGFR4, PTEN
PI-3K cascade:FGFR4R-HSA-56547206.372FGFR4, PTEN
Signaling by ERBB2R-HSA-12279864.662FGFR4, PTEN
PI3K events in ERBB2 signalingR-HSA-19636426.372FGFR4, PTEN
PI-3K cascade:FGFR2R-HSA-56546956.372FGFR4, PTEN
Downstream signaling of activated FGFR2R-HSA-56546964.712FGFR4, PTEN
Signaling by EGFRR-HSA-1779294.592FGFR4, PTEN
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512FGFR4, PTEN
Signalling by NGFR-HSA-1665204.232FGFR4, PTEN
Signaling by FGFR2R-HSA-56547384.682FGFR4, PTEN
Signaling by FGFR1R-HSA-56547364.692FGFR4, PTEN
PI3K events in ERBB4 signalingR-HSA-12503426.372FGFR4, PTEN
PI-3K cascade:FGFR3R-HSA-56547106.372FGFR4, PTEN
DAP12 interactionsR-HSA-21721274.562FGFR4, PTEN
Downstream signaling of activated FGFR4R-HSA-56547164.712FGFR4, PTEN
Signaling by PDGFR-HSA-1867974.532FGFR4, PTEN
Axon guidanceR-HSA-4224753.932FGFR4, EPHB2
DAP12 signalingR-HSA-24244914.642FGFR4, PTEN
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1815ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, MXI1, FGFR4, PTEN, HIP1, KLF6, CD82, CHEK2, MAD1L1
protein binding (GO:0005515) 0.4614ZFHX3, BRCA2, EPHB2, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, HIP1, PTEN, CD82, CHEK2, MAD1L1
organic cyclic compound binding (GO:0097159) 1.059AR, BRCA2, EPHB2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, FGFR4
heterocyclic compound binding (GO:1901363) 1.069AR, BRCA2, EPHB2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, FGFR4
cation binding (GO:0043169) 1.46AR, PTEN, ZFHX3, CDH1, KLF6, CHEK2
ion binding (GO:0043167) 1.366AR, KLF6, ZFHX3, CDH1, PTEN, CHEK2
metal ion binding (GO:0046872) 1.416AR, PTEN, ZFHX3, CDH1, KLF6, CHEK2
nucleic acid binding (GO:0003676) 1.446AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6
DNA binding (GO:0003677) 1.926AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6
catalytic activity (GO:0003824) 1.055CHEK2, FGFR4, BRCA2, PTEN, EPHB2
enzyme binding (GO:0019899) 2.275AR, CHEK2, BRCA2, ZFHX3, PTEN
carbohydrate derivative binding (GO:0097367) 2.034CHEK2, FGFR4, EPHB2, CDH1
molecular transducer activity (GO:0060089) 2.324MSR1, AR, FGFR4, EPHB2
transferase activity (GO:0016740) 1.954CHEK2, BRCA2, FGFR4, EPHB2
receptor activity (GO:0004872) 2.324MSR1, AR, FGFR4, EPHB2
signaling receptor activity (GO:0038023) 2.493AR, FGFR4, EPHB2
purine ribonucleoside triphosphate binding (GO:0035639) 2.223CHEK2, FGFR4, EPHB2
macromolecular complex binding (GO:0044877) 2.613AR, MSR1, PTEN
nucleic acid binding transcription factor activity (GO:0001071) 2.653AR, ZFHX3, KLF6
signal transducer activity (GO:0004871) 2.283AR, FGFR4, EPHB2
nucleoside phosphate binding (GO:1901265) 1.963CHEK2, FGFR4, EPHB2
nucleoside binding (GO:0001882) 2.213CHEK2, FGFR4, EPHB2
sequence-specific DNA binding (GO:0043565) 2.793AR, HOXB13, ZFHX3
nucleotide binding (GO:0000166) 1.963CHEK2, FGFR4, EPHB2
purine nucleoside binding (GO:0001883) 2.223CHEK2, FGFR4, EPHB2
ribonucleoside binding (GO:0032549) 2.223CHEK2, FGFR4, EPHB2
purine nucleotide binding (GO:0017076) 2.193CHEK2, FGFR4, EPHB2
double-stranded DNA binding (GO:0003690) 3.093AR, ZFHX3, KLF6
identical protein binding (GO:0042802) 2.633CHEK2, PTEN, EPHB2
kinase activity (GO:0016301) 2.933CHEK2, FGFR4, EPHB2
lipid binding (GO:0008289) 3.263AR, HIP1, PTEN
small molecule binding (GO:0036094) 1.893CHEK2, FGFR4, EPHB2
protein kinase activity (GO:0004672) 3.273CHEK2, FGFR4, EPHB2
receptor binding (GO:0005102) 2.433AR, PTEN, EPHB2
cytoskeletal protein binding (GO:0008092) 3.023BRCA2, HIP1, CDH1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083CHEK2, FGFR4, EPHB2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773CHEK2, FGFR4, EPHB2
adenyl nucleotide binding (GO:0030554) 2.43CHEK2, FGFR4, EPHB2
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653AR, ZFHX3, KLF6
adenyl ribonucleotide binding (GO:0032559) 2.413CHEK2, FGFR4, EPHB2
ATP binding (GO:0005524) 2.433CHEK2, FGFR4, EPHB2
purine ribonucleotide binding (GO:0032555) 2.23CHEK2, FGFR4, EPHB2
protein dimerization activity (GO:0046983) 2.723CHEK2, MXI1, AR
purine ribonucleoside binding (GO:0032550) 2.223CHEK2, FGFR4, EPHB2
ribonucleotide binding (GO:0032553) 2.193CHEK2, FGFR4, EPHB2
transcription regulatory region DNA binding (GO:0044212) 3.032AR, ZFHX3
sequence-specific double-stranded DNA binding (GO:1990837) 3.22AR, ZFHX3
transition metal ion binding (GO:0046914) 2.482AR, ZFHX3
regulatory region nucleic acid binding (GO:0001067) 3.032AR, ZFHX3
transmembrane signaling receptor activity (GO:0004888) 2.572FGFR4, EPHB2
beta-catenin binding (GO:0008013) 5.32AR, CDH1
protein kinase binding (GO:0019901) 3.442CHEK2, PTEN
kinase binding (GO:0019900) 3.322CHEK2, PTEN
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552FGFR4, EPHB2
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242AR, ZFHX3
protein tyrosine kinase activity (GO:0004713) 4.542FGFR4, EPHB2
regulatory region DNA binding (GO:0000975) 3.032AR, ZFHX3
transmembrane receptor protein kinase activity (GO:0019199) 5.322FGFR4, EPHB2
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292AR, ZFHX3
transmembrane receptor activity (GO:0099600) 2.532FGFR4, EPHB2
zinc ion binding (GO:0008270) 2.662AR, ZFHX3

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) -2.790.023AR, BRCA2, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
protein heterodimerization activity (GO:0046982) NEW3.640.0AR, BRCA2, EPHB2, CDH1, MAD1L1, PTEN, CD82, CHEK2, HIP1
cytoskeletal protein binding (GO:0008092) -3.020.006EPHB2, BRCA2, PTEN, AR, CDH1, MXI1, HIP1, KLF6, MAD1L1
transcription corepressor activity (GO:0003714) NEW4.330.047MXI1, CHEK2, AR, PTEN, CDH1
regulatory region nucleic acid binding (GO:0001067) -3.030.023AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
growth factor binding (GO:0019838) NEW4.890.04AR, FGFR4, PTEN, CDH1
glycosaminoglycan binding (GO:0005539) NEW4.420.038CHEK2, AR, FGFR4, PTEN, CDH1
frizzled binding (GO:0005109) NEW6.10.009PTEN, CDH1, EPHB2
transcription regulatory region DNA binding (GO:0044212) -3.030.021AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
regulatory region DNA binding (GO:0000975) -3.030.023AR, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
calcium channel regulator activity (GO:0005246) NEW6.150.017PTEN, EPHB2, CD82
protein dimerization activity (GO:0046983) -2.720.003AR, BRCA2, CD82, HOXB13, CDH1, MXI1, PTEN, MAD1L1, EPHB2, CHEK2, HIP1
transmembrane receptor protein kinase activity (GO:0019199) -5.320.005FGFR4, PTEN, CDH1, EPHB2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3915ZFHX3, BRCA2, EPHB2, HOXB13, MSR1, AR, CDH1, HIP1, KLF6, MXI1, FGFR4, PTEN, CD82, CHEK2, MAD1L1
regulation of biological process (GO:0050789) 0.4515ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, HIP1, PTEN, CD82, CHEK2, MAD1L1
regulation of cellular process (GO:0050794) 0.515ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, HIP1, PTEN, CD82, CHEK2, MAD1L1
cellular process (GO:0009987) 0.2614ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, HIP1, PTEN, CHEK2, MAD1L1
single-organism process (GO:0044699) 0.4814ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, PTEN, CHEK2, HIP1, MAD1L1
single-organism cellular process (GO:0044763) 0.6512EPHB2, BRCA2, KLF6, AR, HOXB13, HIP1, CDH1, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
primary metabolic process (GO:0044238) 0.6911ZFHX3, BRCA2, EPHB2, HOXB13, AR, MXI1, PTEN, FGFR4, KLF6, CHEK2, HIP1
regulation of metabolic process (GO:0019222) 1.0211ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, FGFR4, PTEN, CHEK2, HIP1
cellular macromolecule metabolic process (GO:0044260) 0.9311EPHB2, BRCA2, KLF6, AR, HOXB13, ZFHX3, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.4311ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, FGFR4, KLF6, CHEK2, HIP1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.4611AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of macromolecule metabolic process (GO:0060255) 1.0811ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, HIP1, KLF6, CHEK2, FGFR4
regulation of biosynthetic process (GO:0009889) 1.3711ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, FGFR4, PTEN, CHEK2, HIP1
cellular metabolic process (GO:0044237) 0.6911ZFHX3, BRCA2, EPHB2, HOXB13, AR, KLF6, MXI1, FGFR4, PTEN, CHEK2, HIP1
macromolecule metabolic process (GO:0043170) 0.8311ZFHX3, BRCA2, EPHB2, HOXB13, AR, KLF6, MXI1, FGFR4, PTEN, CHEK2, HIP1
regulation of cellular metabolic process (GO:0031323) 1.0711AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
organic substance metabolic process (GO:0071704) 0.6311EPHB2, BRCA2, PTEN, AR, HOXB13, ZFHX3, MXI1, HIP1, KLF6, CHEK2, FGFR4
regulation of macromolecule biosynthetic process (GO:0010556) 1.4311AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of nitrogen compound metabolic process (GO:0051171) 1.3611ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
metabolic process (GO:0008152) 0.5811ZFHX3, BRCA2, EPHB2, HOXB13, AR, MXI1, PTEN, FGFR4, KLF6, CHEK2, HIP1
regulation of cellular biosynthetic process (GO:0031326) 1.3811ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, FGFR4, KLF6, CHEK2, HIP1
positive regulation of biological process (GO:0048518) 1.211EPHB2, BRCA2, KLF6, AR, ZFHX3, CDH1, MSR1, HIP1, PTEN, CHEK2, FGFR4
regulation of gene expression (GO:0010468) 1.3711ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, FGFR4, PTEN, CHEK2, HIP1
regulation of primary metabolic process (GO:0080090) 1.0811ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, FGFR4, PTEN, CHEK2, HIP1
positive regulation of cellular process (GO:0048522) 1.311EPHB2, ZFHX3, BRCA2, PTEN, AR, CDH1, MSR1, FGFR4, KLF6, CHEK2, HIP1
organic substance biosynthetic process (GO:1901576) 1.3410ZFHX3, BRCA2, PTEN, HOXB13, AR, MXI1, FGFR4, KLF6, CHEK2, HIP1
cellular biosynthetic process (GO:0044249) 1.3710ZFHX3, BRCA2, KLF6, HOXB13, AR, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of RNA metabolic process (GO:0051252) 1.5210ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, KLF6, CHEK2, HIP1
regulation of nucleic acid-templated transcription (GO:1903506) 1.5510AR, BRCA2, PTEN, HOXB13, ZFHX3, CDH1, MXI1, KLF6, CHEK2, HIP1
regulation of transcription, DNA-templated (GO:0006355) 1.5610ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, PTEN, CHEK2, HIP1
biosynthetic process (GO:0009058) 1.3210ZFHX3, BRCA2, PTEN, HOXB13, AR, MXI1, FGFR4, KLF6, CHEK2, HIP1
regulation of RNA biosynthetic process (GO:2001141) 1.5510ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, KLF6, CHEK2, HIP1
developmental process (GO:0032502) 1.369AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
positive regulation of metabolic process (GO:0009893) 1.749ZFHX3, BRCA2, PTEN, AR, CDH1, FGFR4, KLF6, CHEK2, HIP1
response to stimulus (GO:0050896) 1.229ZFHX3, BRCA2, PTEN, HOXB13, CDH1, MSR1, KLF6, CHEK2, FGFR4
positive regulation of cellular metabolic process (GO:0031325) 1.819AR, BRCA2, KLF6, ZFHX3, CDH1, HIP1, PTEN, CHEK2, FGFR4
single-organism developmental process (GO:0044767) 1.499AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, MAD1L1
negative regulation of biological process (GO:0048519) 1.339ZFHX3, BRCA2, EPHB2, AR, CDH1, MXI1, PTEN, CHEK2, MAD1L1
response to chemical (GO:0042221) 1.989ZFHX3, BRCA2, KLF6, HOXB13, CDH1, MSR1, PTEN, CHEK2, FGFR4
response to organic substance (GO:0010033) 2.29ZFHX3, BRCA2, KLF6, HOXB13, CDH1, MSR1, PTEN, CHEK2, FGFR4
negative regulation of cellular process (GO:0048523) 1.419ZFHX3, BRCA2, EPHB2, AR, CDH1, MXI1, PTEN, CHEK2, MAD1L1
positive regulation of macromolecule metabolic process (GO:0010604) 1.819AR, BRCA2, KLF6, ZFHX3, CDH1, FGFR4, PTEN, CHEK2, HIP1
nucleobase-containing compound metabolic process (GO:0006139) 1.358AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.598ZFHX3, BRCA2, HOXB13, AR, MXI1, KLF6, CHEK2, HIP1
cellular component organization or biogenesis (GO:0071840) 1.228AR, BRCA2, EPHB2, CDH1, MAD1L1, PTEN, CHEK2, HIP1
anatomical structure development (GO:0048856) 1.588AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, PTEN, MAD1L1
cellular aromatic compound metabolic process (GO:0006725) 1.38AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
cellular nitrogen compound metabolic process (GO:0034641) 1.228AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
cellular component organization (GO:0016043) 1.248AR, BRCA2, EPHB2, CDH1, HIP1, PTEN, CHEK2, MAD1L1
nucleic acid metabolic process (GO:0090304) 1.468AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
response to organic cyclic compound (GO:0014070) 3.078MSR1, BRCA2, PTEN, HOXB13, CDH1, KLF6, CHEK2, FGFR4
macromolecule biosynthetic process (GO:0009059) 1.618ZFHX3, BRCA2, HOXB13, AR, MXI1, KLF6, CHEK2, HIP1
nitrogen compound metabolic process (GO:0006807) 1.138AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
signal transduction (GO:0007165) 1.288AR, BRCA2, CD82, HIP1, FGFR4, PTEN, CHEK2, EPHB2
cellular macromolecule biosynthetic process (GO:0034645) 1.668AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.728AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
aromatic compound biosynthetic process (GO:0019438) 1.78AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
heterocycle metabolic process (GO:0046483) 1.318AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
organic cyclic compound biosynthetic process (GO:1901362) 1.668AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
organic cyclic compound metabolic process (GO:1901360) 1.268AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
heterocycle biosynthetic process (GO:0018130) 1.78AR, BRCA2, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
RNA metabolic process (GO:0016070) 1.597AR, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
response to oxygen-containing compound (GO:1901700) 2.577BRCA2, KLF6, HOXB13, CDH1, PTEN, CHEK2, FGFR4
regulation of biological quality (GO:0065008) 1.687MSR1, BRCA2, EPHB2, MXI1, PTEN, CHEK2, FGFR4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.357ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
RNA biosynthetic process (GO:0032774) 1.847AR, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
positive regulation of biosynthetic process (GO:0009891) 2.297ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
cellular developmental process (GO:0048869) 1.827EPHB2, BRCA2, KLF6, HOXB13, PTEN, CHEK2, HIP1
positive regulation of cellular biosynthetic process (GO:0031328) 2.37ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.397ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
positive regulation of gene expression (GO:0010628) 2.357ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
transcription, DNA-templated (GO:0006351) 1.917AR, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.297ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2, FGFR4
regulation of localization (GO:0032879) 1.947AR, MSR1, CDH1, MXI1, MAD1L1, PTEN, HIP1
nucleic acid-templated transcription (GO:0097659) 1.917AR, HOXB13, ZFHX3, MXI1, KLF6, CHEK2, HIP1
regulation of cell proliferation (GO:0042127) 2.416AR, BRCA2, MXI1, MAD1L1, PTEN, FGFR4
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.566ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2
cellular response to stimulus (GO:0051716) 1.976BRCA2, KLF6, CDH1, PTEN, MSR1, CHEK2
multicellular organismal process (GO:0032501) 1.456ZFHX3, BRCA2, PTEN, HOXB13, MSR1, EPHB2
negative regulation of metabolic process (GO:0009892) 1.936AR, BRCA2, ZFHX3, MXI1, PTEN, CHEK2
single-multicellular organism process (GO:0044707) 1.786ZFHX3, BRCA2, PTEN, HOXB13, MSR1, EPHB2
positive regulation of RNA metabolic process (GO:0051254) 2.516ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2
regulation of cellular component organization (GO:0051128) 2.016AR, EPHB2, MAD1L1, FGFR4, PTEN, HIP1
positive regulation of RNA biosynthetic process (GO:1902680) 2.546ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2
animal organ development (GO:0048513) 2.536AR, BRCA2, ZFHX3, CDH1, PTEN, MAD1L1
positive regulation of transcription, DNA-templated (GO:0045893) 2.566ZFHX3, BRCA2, AR, CDH1, KLF6, CHEK2
negative regulation of macromolecule metabolic process (GO:0010605) 2.016AR, BRCA2, ZFHX3, MXI1, PTEN, CHEK2
localization (GO:0051179) 1.46AR, BRCA2, CDH1, MXI1, MSR1, HIP1
negative regulation of cell proliferation (GO:0008285) 3.265MXI1, PTEN, BRCA2, AR, MAD1L1
protein modification process (GO:0036211) 1.795CHEK2, FGFR4, BRCA2, PTEN, EPHB2
establishment of localization (GO:0051234) 1.485MSR1, AR, BRCA2, HIP1, CDH1
regulation of cellular localization (GO:0060341) 3.035MXI1, AR, PTEN, MAD1L1, CDH1
negative regulation of biosynthetic process (GO:0009890) 2.475CHEK2, MXI1, BRCA2, AR, ZFHX3
cellular protein metabolic process (GO:0044267) 1.635CHEK2, FGFR4, BRCA2, PTEN, EPHB2
protein metabolic process (GO:0019538) 1.455CHEK2, FGFR4, BRCA2, PTEN, EPHB2
regulation of cell cycle (GO:0051726) 2.935CHEK2, BRCA2, PTEN, MAD1L1, ZFHX3
negative regulation of cellular metabolic process (GO:0031324) 2.015MXI1, BRCA2, CHEK2, PTEN, ZFHX3
response to stress (GO:0006950) 1.85CHEK2, PTEN, BRCA2, HOXB13, KLF6
cellular protein modification process (GO:0006464) 1.795CHEK2, FGFR4, BRCA2, PTEN, EPHB2
macromolecule modification (GO:0043412) 1.735CHEK2, FGFR4, BRCA2, PTEN, EPHB2
cellular component assembly (GO:0022607) 2.145CHEK2, AR, PTEN, HIP1, CDH1
cellular response to chemical stimulus (GO:0070887) 2.575CDH1, CHEK2, MSR1, KLF6, PTEN
regulation of signaling (GO:0023051) 1.725CHEK2, AR, FGFR4, PTEN, EPHB2
regulation of cell communication (GO:0010646) 1.735CHEK2, AR, FGFR4, PTEN, EPHB2
regulation of cell differentiation (GO:0045595) 2.425MSR1, AR, PTEN, EPHB2, ZFHX3
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.535MXI1, BRCA2, CHEK2, AR, ZFHX3
regulation of phosphate metabolic process (GO:0019220) 2.354CHEK2, AR, FGFR4, PTEN
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474MXI1, BRCA2, CHEK2, ZFHX3
regulation of cell cycle process (GO:0010564) 3.54CHEK2, BRCA2, PTEN, MAD1L1
negative regulation of cellular biosynthetic process (GO:0031327) 2.494MXI1, BRCA2, CHEK2, ZFHX3
regulation of transport (GO:0051049) 2.244HIP1, MXI1, PTEN, CDH1
regulation of response to stimulus (GO:0048583) 1.544CHEK2, AR, FGFR4, PTEN
negative regulation of cellular component organization (GO:0051129) 3.354EPHB2, AR, PTEN, MAD1L1
cell cycle process (GO:0022402) 2.754CHEK2, BRCA2, ZFHX3, MAD1L1
cell surface receptor signaling pathway (GO:0007166) 2.094FGFR4, PTEN, EPHB2, CD82
intracellular signal transduction (GO:0035556) 2.394CHEK2, BRCA2, FGFR4, PTEN
regulation of cell death (GO:0010941) 2.434CHEK2, AR, HIP1, PTEN
regulation of apoptotic process (GO:0042981) 2.54AR, PTEN, CHEK2, HIP1
response to endogenous stimulus (GO:0009719) 2.794ZFHX3, PTEN, KLF6, CDH1
regulation of mitotic cell cycle (GO:0007346) 3.714CHEK2, BRCA2, PTEN, MAD1L1
negative regulation of cell cycle (GO:0045786) 3.674CHEK2, PTEN, MAD1L1, ZFHX3
regulation of signal transduction (GO:0009966) 1.844CHEK2, AR, FGFR4, PTEN
response to lipid (GO:0033993) 3.114HOXB13, BRCA2, FGFR4, PTEN
positive regulation of phosphorus metabolic process (GO:0010562) 2.784CHEK2, AR, FGFR4, PTEN
regulation of protein metabolic process (GO:0051246) 1.934HIP1, CHEK2, FGFR4, PTEN
positive regulation of protein metabolic process (GO:0051247) 2.434HIP1, CHEK2, FGFR4, PTEN
peptidyl-amino acid modification (GO:0018193) 2.984CHEK2, BRCA2, FGFR4, EPHB2
negative regulation of developmental process (GO:0051093) 3.174ZFHX3, BRCA2, PTEN, EPHB2
regulation of programmed cell death (GO:0043067) 2.494AR, PTEN, CHEK2, HIP1
positive regulation of cellular protein metabolic process (GO:0032270) 2.494CHEK2, PTEN, FGFR4, HIP1
positive regulation of molecular function (GO:0044093) 2.234HIP1, AR, FGFR4, PTEN
regulation of molecular function (GO:0065009) 1.784HIP1, AR, FGFR4, PTEN
organelle organization (GO:0006996) 2.024CHEK2, BRCA2, PTEN, MAD1L1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554MXI1, BRCA2, CHEK2, ZFHX3
positive regulation of phosphate metabolic process (GO:0045937) 2.784CHEK2, AR, FGFR4, PTEN
regulation of developmental process (GO:0050793) 2.14ZFHX3, BRCA2, PTEN, EPHB2
cellular response to organic substance (GO:0071310) 2.784MSR1, CHEK2, KLF6, CDH1
regulation of phosphorus metabolic process (GO:0051174) 2.354CHEK2, AR, FGFR4, PTEN
developmental process involved in reproduction (GO:0003006) 3.364AR, BRCA2, HOXB13, PTEN
single organism reproductive process (GO:0044702) 2.734AR, BRCA2, HOXB13, PTEN
regulation of multicellular organismal process (GO:0051239) 1.874ZFHX3, BRCA2, PTEN, EPHB2
regulation of phosphorylation (GO:0042325) 2.54CHEK2, AR, FGFR4, PTEN
positive regulation of cell differentiation (GO:0045597) 3.014MSR1, AR, ZFHX3, EPHB2
positive regulation of phosphorylation (GO:0042327) 2.94CHEK2, AR, FGFR4, PTEN
regulation of cellular protein metabolic process (GO:0032268) 1.994HIP1, CHEK2, FGFR4, PTEN
reproductive process (GO:0022414) 2.554AR, BRCA2, HOXB13, PTEN
cellular response to organic cyclic compound (GO:0071407) 3.934MSR1, CHEK2, KLF6, CDH1
phosphate-containing compound metabolic process (GO:0006796) 2.164CHEK2, FGFR4, PTEN, EPHB2
regulation of multicellular organismal development (GO:2000026) 2.314ZFHX3, BRCA2, PTEN, EPHB2
cellular response to stress (GO:0033554) 2.514CHEK2, BRCA2, KLF6, PTEN
phosphorus metabolic process (GO:0006793) 2.154CHEK2, FGFR4, PTEN, EPHB2
gland development (GO:0048732) 4.154AR, BRCA2, CDH1, MAD1L1
positive regulation of cellular component organization (GO:0051130) 2.683AR, HIP1, EPHB2
response to inorganic substance (GO:0010035) 3.563KLF6, PTEN, CDH1
macromolecular complex subunit organization (GO:0043933) 2.143AR, BRCA2, HIP1
positive regulation of catalytic activity (GO:0043085) 2.43HIP1, FGFR4, PTEN
cell projection organization (GO:0030030) 3.143CDH1, PTEN, EPHB2
phosphorylation (GO:0016310) 2.633CHEK2, FGFR4, EPHB2
negative regulation of response to stimulus (GO:0048585) 2.523AR, CHEK2, PTEN
apoptotic signaling pathway (GO:0097190) 4.123CHEK2, BRCA2, HIP1
protein phosphorylation (GO:0006468) 2.893CHEK2, FGFR4, EPHB2
movement of cell or subcellular component (GO:0006928) 2.613FGFR4, PTEN, EPHB2
regulation of cellular protein localization (GO:1903827) 3.433MXI1, AR, CDH1
negative regulation of cell adhesion (GO:0007162) 4.333PTEN, MAD1L1, CDH1
negative regulation of mitotic cell cycle phase transition (GO:1901991) 4.823CHEK2, PTEN, MAD1L1
regulation of mitotic cell cycle phase transition (GO:1901990) 4.233CHEK2, PTEN, MAD1L1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.243FGFR4, PTEN, EPHB2
positive regulation of cell death (GO:0010942) 3.323CHEK2, HIP1, PTEN
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.543FGFR4, PTEN, EPHB2
cell death (GO:0008219) 3.053CHEK2, HIP1, PTEN
anatomical structure morphogenesis (GO:0009653) 2.533HOXB13, PTEN, EPHB2
developmental maturation (GO:0021700) 4.73HOXB13, BRCA2, PTEN
multicellular organism development (GO:0007275) 2.543HOXB13, BRCA2, EPHB2
cell cycle (GO:0007049) 3.143CHEK2, BRCA2, MAD1L1
regulation of protein localization (GO:0032880) 2.883MXI1, AR, CDH1
regulation of neurogenesis (GO:0050767) 3.213ZFHX3, PTEN, EPHB2
angiogenesis (GO:0001525) 4.153HOXB13, PTEN, EPHB2
negative regulation of cell differentiation (GO:0045596) 3.333ZFHX3, PTEN, EPHB2
negative regulation of multicellular organismal process (GO:0051241) 2.843BRCA2, PTEN, EPHB2
nuclear division (GO:0000280) 3.853CHEK2, BRCA2, MAD1L1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63CHEK2, BRCA2, ZFHX3
regulation of cell development (GO:0060284) 3.013ZFHX3, PTEN, EPHB2
positive regulation of apoptotic process (GO:0043065) 3.383CHEK2, HIP1, PTEN
regulation of neuron differentiation (GO:0045664) 3.393ZFHX3, PTEN, EPHB2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243AR, ZFHX3, KLF6
negative regulation of cell cycle phase transition (GO:1901988) 4.743CHEK2, PTEN, MAD1L1
regulation of protein modification process (GO:0031399) 2.323CHEK2, FGFR4, PTEN
positive regulation of programmed cell death (GO:0043068) 3.383CHEK2, HIP1, PTEN
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013HOXB13, PTEN, EPHB2
positive regulation of cell proliferation (GO:0008284) 3.013AR, FGFR4, PTEN
negative regulation of mitotic cell cycle (GO:0045930) 4.453CHEK2, PTEN, MAD1L1
regulation of establishment of protein localization (GO:0070201) 3.023MXI1, AR, CDH1
transport (GO:0006810) 1.513AR, MSR1, HIP1
regulation of DNA metabolic process (GO:0051052) 3.873CHEK2, BRCA2, FGFR4
cell proliferation (GO:0008283) 3.233AR, BRCA2, PTEN
regulation of catalytic activity (GO:0050790) 1.973HIP1, FGFR4, PTEN
establishment of protein localization (GO:0045184) 2.533BRCA2, MSR1, CDH1
programmed cell death (GO:0012501) 3.13CHEK2, PTEN, HIP1
regulation of proteolysis (GO:0030162) 3.23HIP1, FGFR4, PTEN
regulation of cell adhesion (GO:0030155) 3.273CDH1, PTEN, MAD1L1
regulation of intracellular signal transduction (GO:1902531) 2.313CHEK2, FGFR4, PTEN
response to abiotic stimulus (GO:0009628) 2.83CHEK2, BRCA2, PTEN
single-organism localization (GO:1902578) 2.093MXI1, MSR1, CDH1
growth (GO:0040007) 3.83AR, BRCA2, PTEN
cellular response to oxygen-containing compound (GO:1901701) 3.223CHEK2, KLF6, CDH1
aging (GO:0007568) 4.163CHEK2, BRCA2, PTEN
regulation of cell cycle phase transition (GO:1901987) 4.153CHEK2, PTEN, MAD1L1
response to organonitrogen compound (GO:0010243) 3.23KLF6, PTEN, CDH1
positive regulation of protein modification process (GO:0031401) 2.73CHEK2, FGFR4, PTEN
response to drug (GO:0042493) 3.713CHEK2, PTEN, CDH1
negative regulation of cell cycle process (GO:0010948) 4.373CHEK2, PTEN, MAD1L1
positive regulation of protein phosphorylation (GO:0001934) 2.953CHEK2, FGFR4, PTEN
response to ketone (GO:1901654) 4.533CHEK2, HOXB13, KLF6
regulation of nervous system development (GO:0051960) 3.13ZFHX3, PTEN, EPHB2
organelle fission (GO:0048285) 3.793CHEK2, BRCA2, MAD1L1
positive regulation of proteolysis (GO:0045862) 3.863HIP1, FGFR4, PTEN
regulation of protein phosphorylation (GO:0001932) 2.573CHEK2, FGFR4, PTEN
response to alcohol (GO:0097305) 4.583KLF6, PTEN, CDH1
response to nitrogen compound (GO:1901698) 3.123PTEN, KLF6, CDH1
apoptotic process (GO:0006915) 3.143CHEK2, HIP1, PTEN
regulation of intracellular protein transport (GO:0033157) 3.82MXI1, CDH1
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692AR, PTEN
response to gamma radiation (GO:0010332) 5.782CHEK2, BRCA2
regulation of neuron projection development (GO:0010975) 3.692PTEN, EPHB2
developmental growth (GO:0048589) 4.052BRCA2, PTEN
regulation of apoptotic signaling pathway (GO:2001233) 3.832AR, PTEN
regulation of intracellular transport (GO:0032386) 3.582MXI1, CDH1
positive regulation of response to stimulus (GO:0048584) 2.182FGFR4, PTEN
cell maturation (GO:0048469) 4.982HOXB13, BRCA2
behavior (GO:0007610) 3.472PTEN, EPHB2
learning or memory (GO:0007611) 4.332PTEN, EPHB2
membrane organization (GO:0061024) 3.042PTEN, CDH1
plasma membrane organization (GO:0007009) 4.82PTEN, CDH1
negative regulation of cell projection organization (GO:0031345) 4.722PTEN, EPHB2
regulation of cell projection organization (GO:0031344) 3.382PTEN, EPHB2
dendritic spine organization (GO:0097061) 6.92PTEN, EPHB2
single-organism metabolic process (GO:0044710) 1.632FGFR4, PTEN
single-organism biosynthetic process (GO:0044711) 2.82FGFR4, PTEN
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) 5.172CHEK2, PTEN
double-strand break repair (GO:0006302) 4.732CHEK2, BRCA2
negative regulation of signal transduction (GO:0009968) 2.752AR, PTEN
positive regulation of signal transduction (GO:0009967) 2.52FGFR4, PTEN
peptidyl-tyrosine modification (GO:0018212) 4.472FGFR4, EPHB2
response to wounding (GO:0009611) 4.392HOXB13, KLF6
negative regulation of neuron differentiation (GO:0045665) 4.452PTEN, EPHB2
rhythmic process (GO:0048511) 4.022ZFHX3, PTEN
negative regulation of cell development (GO:0010721) 4.022PTEN, EPHB2
phosphatidylinositol biosynthetic process (GO:0006661) 4.942FGFR4, PTEN
macromolecule localization (GO:0033036) 2.342MSR1, CDH1
dendritic spine morphogenesis (GO:0060997) 7.432PTEN, EPHB2
negative regulation of DNA metabolic process (GO:0051053) 4.982CHEK2, BRCA2
negative regulation of transport (GO:0051051) 3.62MXI1, PTEN
positive regulation of transport (GO:0051050) 2.92HIP1, CDH1
negative regulation of cell death (GO:0060548) 2.952AR, PTEN
negative regulation of epithelial cell proliferation (GO:0050680) 4.982BRCA2, PTEN
phosphatidylinositol metabolic process (GO:0046488) 4.462FGFR4, PTEN
response to metal ion (GO:0010038) 3.912PTEN, CDH1
regulation of epithelial cell proliferation (GO:0050678) 4.062BRCA2, PTEN
glycerolipid metabolic process (GO:0046486) 3.912FGFR4, PTEN
cell part morphogenesis (GO:0032990) 3.992PTEN, EPHB2
regulation of transcription factor import into nucleus (GO:0042990) 5.162MXI1, CDH1
system process (GO:0003008) 2.32PTEN, EPHB2
single organism signaling (GO:0044700) 3.252AR, PTEN
vesicle-mediated transport (GO:0016192) 2.722MSR1, HIP1
response to external stimulus (GO:0009605) 2.552BRCA2, PTEN
cell motility (GO:0048870) 3.022FGFR4, PTEN
single-organism behavior (GO:0044708) 3.792PTEN, EPHB2
response to nutrient levels (GO:0031667) 3.772BRCA2, PTEN
regulation of DNA replication (GO:0006275) 5.022CHEK2, BRCA2
immune system process (GO:0002376) 2.292PTEN, KLF6
regulation of protein import (GO:1904589) 4.522MXI1, CDH1
catabolic process (GO:0009056) 2.382CHEK2, PTEN
regulation of cell morphogenesis (GO:0022604) 3.42PTEN, EPHB2
regulation of catabolic process (GO:0009894) 3.522CHEK2, PTEN
regulation of anatomical structure morphogenesis (GO:0022603) 2.792PTEN, EPHB2
protein stabilization (GO:0050821) 4.862CHEK2, PTEN
regulation of synaptic plasticity (GO:0048167) 4.782PTEN, EPHB2
neuron projection development (GO:0031175) 4.582PTEN, CDH1
mitotic nuclear division (GO:0007067) 4.052CHEK2, MAD1L1
regulation of protein transport (GO:0051223) 3.122MXI1, CDH1
signal transduction by p53 class mediator (GO:0072331) 4.882CHEK2, BRCA2
organic substance catabolic process (GO:1901575) 2.452CHEK2, PTEN
positive regulation of hydrolase activity (GO:0051345) 2.912HIP1, FGFR4
macromolecular complex assembly (GO:0065003) 2.552AR, HIP1
regulation of immune system process (GO:0002682) 2.52PTEN, MAD1L1
cell migration (GO:0016477) 3.122FGFR4, PTEN
organ morphogenesis (GO:0009887) 3.552PTEN, EPHB2
circadian rhythm (GO:0007623) 4.792ZFHX3, PTEN
lipid metabolic process (GO:0006629) 2.682FGFR4, PTEN
tissue development (GO:0009888) 3.272HOXB13, PTEN
positive regulation of MAPK cascade (GO:0043410) 3.572FGFR4, PTEN
organophosphate metabolic process (GO:0019637) 3.042FGFR4, PTEN
negative regulation of DNA replication (GO:0008156) 6.172CHEK2, BRCA2
single-organism membrane organization (GO:0044802) 3.192PTEN, CDH1
system development (GO:0048731) 2.922PTEN, EPHB2
regulation of protein import into nucleus (GO:0042306) 4.542MXI1, CDH1
organophosphate biosynthetic process (GO:0090407) 3.672FGFR4, PTEN
inositol lipid-mediated signaling (GO:0048017) 4.912FGFR4, PTEN
positive regulation of cell cycle (GO:0045787) 3.942CHEK2, BRCA2
regulation of hydrolase activity (GO:0051336) 2.532HIP1, FGFR4
regulation of protein localization to nucleus (GO:1900180) 4.342MXI1, CDH1
endocytosis (GO:0006897) 3.692MSR1, HIP1
brain development (GO:0007420) 4.242ZFHX3, BRCA2
phospholipid biosynthetic process (GO:0008654) 4.392FGFR4, PTEN
regulation of response to stress (GO:0080134) 2.532CHEK2, PTEN
receptor-mediated endocytosis (GO:0006898) 4.312MSR1, HIP1
cognition (GO:0050890) 4.22PTEN, EPHB2
negative regulation of nervous system development (GO:0051961) 4.152PTEN, EPHB2
neuron projection morphogenesis (GO:0048812) 4.342PTEN, EPHB2
regulation of nucleocytoplasmic transport (GO:0046822) 4.332MXI1, CDH1
nervous system development (GO:0007399) 3.532PTEN, EPHB2
cellular response to alcohol (GO:0097306) 6.072KLF6, CDH1
synapse organization (GO:0050808) 4.872PTEN, CDH1
regulation of synapse structure or activity (GO:0050803) 4.772PTEN, EPHB2
response to radiation (GO:0009314) 3.692CHEK2, BRCA2
cell differentiation (GO:0030154) 2.142HIP1, KLF6
modulation of synaptic transmission (GO:0050804) 4.092PTEN, EPHB2
positive regulation of signaling (GO:0023056) 2.412FGFR4, PTEN
negative regulation of signaling (GO:0023057) 2.652AR, PTEN
regulation of protein catabolic process (GO:0042176) 3.832CHEK2, PTEN
signaling (GO:0023052) 3.252AR, PTEN
negative regulation of cell communication (GO:0010648) 2.662AR, PTEN
regulation of protein targeting (GO:1903533) 4.02MXI1, CDH1
positive regulation of intracellular signal transduction (GO:1902533) 2.952FGFR4, PTEN
positive regulation of cell communication (GO:0010647) 2.412FGFR4, PTEN
regulation of DNA-dependent DNA replication (GO:0090329) 5.972CHEK2, BRCA2
protein autophosphorylation (GO:0046777) 4.462CHEK2, FGFR4
synapse assembly (GO:0007416) 5.552PTEN, CDH1
regulation of MAPK cascade (GO:0043408) 3.222FGFR4, PTEN
organelle assembly (GO:0070925) 3.752CHEK2, PTEN
response to ionizing radiation (GO:0010212) 4.742CHEK2, BRCA2
phosphatidylinositol-mediated signaling (GO:0048015) 4.932FGFR4, PTEN
negative regulation of neurogenesis (GO:0050768) 4.222PTEN, EPHB2
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912PTEN, EPHB2
central nervous system neuron axonogenesis (GO:0021955) 6.512PTEN, EPHB2
cellular response to endogenous stimulus (GO:0071495) 3.332KLF6, CDH1
phospholipid metabolic process (GO:0006644) 3.882FGFR4, PTEN
reproductive structure development (GO:0048608) 4.082AR, BRCA2
multicellular organismal reproductive process (GO:0048609) 3.352BRCA2, PTEN
cellular response to nitrogen compound (GO:1901699) 3.792KLF6, CDH1
neurological system process (GO:0050877) 2.642PTEN, EPHB2
regulation of vesicle-mediated transport (GO:0060627) 3.632HIP1, PTEN
cellular response to DNA damage stimulus (GO:0006974) 3.172CHEK2, BRCA2
mitotic cell cycle process (GO:1903047) 3.122CHEK2, MAD1L1
axonogenesis (GO:0007409) 4.742PTEN, EPHB2
cellular lipid metabolic process (GO:0044255) 2.922FGFR4, PTEN
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792FGFR4, PTEN
lipid modification (GO:0030258) 4.372FGFR4, PTEN
cell projection morphogenesis (GO:0048858) 4.052PTEN, EPHB2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292AR, PTEN
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832AR, PTEN
negative regulation of axonogenesis (GO:0050771) 5.522PTEN, EPHB2
regulation of G1/S transition of mitotic cell cycle (GO:2000045) 4.812CHEK2, PTEN
positive regulation of developmental process (GO:0051094) 2.772ZFHX3, EPHB2
negative regulation of RNA metabolic process (GO:0051253) 2.662MXI1, ZFHX3
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712MXI1, ZFHX3
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812AR, KLF6
negative regulation of cell morphogenesis involved in differentiation (GO:0010771) 4.962PTEN, EPHB2
glycerophospholipid biosynthetic process (GO:0046474) 4.622FGFR4, PTEN
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562FGFR4, PTEN
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232FGFR4, PTEN
response to extracellular stimulus (GO:0009991) 3.712BRCA2, PTEN
regulation of protein stability (GO:0031647) 4.332CHEK2, PTEN
glycerophospholipid metabolic process (GO:0006650) 4.132FGFR4, PTEN
regulation of axonogenesis (GO:0050770) 4.592PTEN, EPHB2
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) 5.442CHEK2, BRCA2
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482FGFR4, EPHB2
intrinsic apoptotic signaling pathway (GO:0097193) 4.692CHEK2, BRCA2
homeostatic process (GO:0042592) 2.612BRCA2, FGFR4
regulation of cell-cell adhesion (GO:0022407) 3.792CDH1, MAD1L1
cell division (GO:0051301) 3.682CHEK2, MAD1L1
glycerolipid biosynthetic process (GO:0045017) 4.532FGFR4, PTEN
response to estradiol (GO:0032355) 4.732BRCA2, PTEN
protein complex subunit organization (GO:0071822) 2.62AR, HIP1
negative regulation of cell cycle G1/S phase transition (GO:1902807) 5.142CHEK2, PTEN
regulation of growth (GO:0040008) 3.262HOXB13, PTEN
DNA repair (GO:0006281) 3.592CHEK2, BRCA2
cellular component morphogenesis (GO:0032989) 3.52PTEN, EPHB2
negative regulation of apoptotic process (GO:0043066) 3.042AR, PTEN
negative regulation of cell-cell adhesion (GO:0022408) 4.842MAD1L1, CDH1
hematopoietic or lymphoid organ development (GO:0048534) 4.492BRCA2, MAD1L1
negative regulation of programmed cell death (GO:0043069) 3.022AR, PTEN
DNA damage response, signal transduction by p53 class mediator (GO:0030330) 5.32CHEK2, BRCA2
response to nutrient (GO:0007584) 4.492BRCA2, PTEN
protein complex assembly (GO:0006461) 2.782AR, HIP1
negative regulation of RNA biosynthetic process (GO:1902679) 2.72MXI1, ZFHX3
cell-cell signaling (GO:0007267) 3.352AR, PTEN
cell communication (GO:0007154) 3.042AR, PTEN
cell aging (GO:0007569) 5.542CHEK2, BRCA2
regulation of endocytosis (GO:0030100) 4.422HIP1, PTEN
signal transduction in response to DNA damage (GO:0042770) 5.152CHEK2, BRCA2
lipid biosynthetic process (GO:0008610) 3.492FGFR4, PTEN
locomotion (GO:0040011) 2.912FGFR4, PTEN
chromosome organization (GO:0051276) 3.792BRCA2, MAD1L1
cell cycle checkpoint (GO:0000075) 4.792CHEK2, MAD1L1
negative regulation of DNA-dependent DNA replication (GO:2000104) 6.962CHEK2, BRCA2
regulation of cell cycle G1/S phase transition (GO:1902806) 4.742CHEK2, PTEN
regulation of cellular component biogenesis (GO:0044087) 3.082PTEN, EPHB2
regulation of cellular response to stress (GO:0080135) 3.42CHEK2, PTEN
DNA metabolic process (GO:0006259) 3.092CHEK2, BRCA2
negative regulation of neuron projection development (GO:0010977) 4.882PTEN, EPHB2
cellular response to organonitrogen compound (GO:0071417) 3.872KLF6, CDH1

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of cellular biosynthetic process (GO:0031326) -1.380.011ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, FGFR4, KLF6, CHEK2, HIP1
apoptotic signaling pathway (GO:0097190) -4.120.012AR, BRCA2, EPHB2, CDH1, PTEN, CHEK2, HIP1
cell maturation (GO:0048469) -4.980.037CHEK2, HOXB13, BRCA2, AR, CDH1
male gonad development (GO:0008584) NEW5.080.003CHEK2, AR, PTEN, CDH1, MAD1L1
regulation of muscle cell differentiation (GO:0051147) NEW4.680.017ZFHX3, CHEK2, PTEN, CDH1, CD82
reproductive structure development (GO:0048608) -4.080.0AR, BRCA2, EPHB2, HOXB13, CDH1, FGFR4, PTEN, CHEK2, MAD1L1
macromolecular complex assembly (GO:0065003) -2.550.008AR, BRCA2, EPHB2, CDH1, MXI1, PTEN, HIP1, KLF6, CD82, CHEK2, MAD1L1
developmental maturation (GO:0021700) -4.70.011AR, BRCA2, HOXB13, CDH1, PTEN, CHEK2
regulation of cell division (GO:0051302) NEW4.880.037AR, BRCA2, CDH1, PTEN, CHEK2, MAD1L1
regulation of cellular macromolecule biosynthetic process (GO:2000112) -1.460.005AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of neurogenesis (GO:0050767) -3.210.016AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, FGFR4
regulation of sodium-dependent phosphate transport (GO:2000118) NEW8.630.022AR, CDH1
positive regulation of nervous system development (GO:0051962) NEW3.640.042AR, CDH1, EPHB2
cell proliferation (GO:0008283) -3.230.004AR, BRCA2, EPHB2, HOXB13, CDH1, MXI1, PTEN, CD82, CHEK2, MAD1L1
nuclear division (GO:0000280) -3.850.007AR, BRCA2, CDH1, HIP1, PTEN, CHEK2, MAD1L1
negative regulation of neuron differentiation (GO:0045665) -4.450.026CHEK2, AR, PTEN, CDH1
regulation of nervous system development (GO:0051960) -3.10.031AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, PTEN, CHEK2, FGFR4
tissue morphogenesis (GO:0048729) NEW3.870.043AR, PTEN, HOXB13, CDH1, KLF6, CHEK2, EPHB2
positive regulation of biological process (GO:0048518) -1.20.027EPHB2, ZFHX3, BRCA2, PTEN, AR, CDH1, MSR1, FGFR4, KLF6, CHEK2, HIP1
positive regulation of integrin biosynthetic process (GO:0045726) NEW8.630.022AR, CDH1
cell migration (GO:0016477) -3.120.042EPHB2, AR, KLF6, CDH1, FGFR4, PTEN, CD82, CHEK2, MAD1L1
regulation of gene expression (GO:0010468) -1.370.014AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
developmental process (GO:0032502) -1.360.03EPHB2, ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, FGFR4, KLF6, CHEK2, HIP1
organ morphogenesis (GO:0009887) -3.550.02AR, BRCA2, EPHB2, HOXB13, CDH1, MXI1, PTEN, CHEK2
protein complex assembly (GO:0006461) -2.780.025AR, BRCA2, EPHB2, CDH1, MXI1, HIP1, PTEN, CD82, CHEK2, MAD1L1
neurotrophin signaling pathway (GO:0038179) NEW6.550.035EPHB2, AR, CD82, CDH1, PTEN, FGFR4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) -2.550.009ZFHX3, BRCA2, CD82, HOXB13, AR, CDH1, MXI1, PTEN, EPHB2, CHEK2, MAD1L1
dendritic spine organization (GO:0097061) -6.90.04PTEN, EPHB2
regulation of nucleobase-containing compound metabolic process (GO:0019219) -1.430.027AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
gonad development (GO:0008406) NEW4.920.001AR, BRCA2, CDH1, PTEN, CHEK2, MAD1L1
epithelium development (GO:0060429) NEW4.570.0AR, EPHB2, HOXB13, CDH1, MXI1, PTEN, CHEK2, FGFR4
regulation of biosynthetic process (GO:0009889) -1.370.012ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, HIP1, KLF6, CHEK2, FGFR4
tissue development (GO:0009888) -3.270.004AR, BRCA2, CD82, HOXB13, CDH1, MXI1, FGFR4, PTEN, CHEK2, EPHB2
positive regulation of cell differentiation (GO:0045597) -3.010.003AR, BRCA2, EPHB2, HOXB13, ZFHX3, CDH1, MSR1, PTEN, CHEK2, HIP1
regulation of cell cycle phase transition (GO:1901987) -4.150.018AR, BRCA2, CDH1, PTEN, CHEK2, MAD1L1
regulation of nitrogen compound metabolic process (GO:0051171) -1.360.033AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
regulation of RNA biosynthetic process (GO:2001141) -1.550.031ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, KLF6, CHEK2, HIP1
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.029EPHB2, AR, CD82, CDH1, PTEN, FGFR4
negative regulation of cell cycle phase transition (GO:1901988) -4.740.042CDH1, CHEK2, AR, PTEN, MAD1L1
brain development (GO:0007420) -4.240.028ZFHX3, BRCA2, AR, CDH1, CHEK2, FGFR4
epithelial cell maturation involved in prostate gland development (GO:0060743) NEW8.630.03AR, HOXB13
sex differentiation (GO:0007548) NEW6.330.018AR, PTEN, CDH1
single organism reproductive process (GO:0044702) -2.730.008AR, BRCA2, EPHB2, HOXB13, HIP1, CDH1, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
cell aging (GO:0007569) -5.540.0AR, CHEK2, BRCA2, PTEN, CDH1
positive regulation of developmental process (GO:0051094) -2.770.0EPHB2, BRCA2, CD82, AR, HOXB13, ZFHX3, CDH1, MSR1, HIP1, PTEN, CHEK2, FGFR4
regulation of RNA metabolic process (GO:0051252) -1.520.038AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, PTEN, CHEK2, HIP1
dendritic spine morphogenesis (GO:0060997) -7.430.014PTEN, EPHB2
regulation of transcription, DNA-templated (GO:0006355) -1.560.027ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, MXI1, KLF6, CHEK2, HIP1
regulation of macromolecule biosynthetic process (GO:0010556) -1.430.007AR, BRCA2, KLF6, HOXB13, ZFHX3, CDH1, MXI1, HIP1, PTEN, CHEK2, FGFR4
organelle fission (GO:0048285) -3.790.013AR, BRCA2, CDH1, HIP1, PTEN, CHEK2, MAD1L1
positive regulation of synapse assembly (GO:0051965) NEW5.620.042AR, CDH1, EPHB2
developmental process involved in reproduction (GO:0003006) -3.360.001AR, BRCA2, EPHB2, HOXB13, CDH1, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1115ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, MXI1, PTEN, FGFR4, KLF6, CD82, CHEK2, HIP1, MAD1L1
intracellular part (GO:0044424) 0.2814ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, KLF6, MXI1, FGFR4, HIP1, PTEN, CHEK2, MAD1L1
membrane-bounded organelle (GO:0043227) 0.4714ZFHX3, BRCA2, CD82, AR, HOXB13, HIP1, CDH1, MSR1, KLF6, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
organelle (GO:0043226) 0.414ZFHX3, BRCA2, CD82, AR, HOXB13, HIP1, CDH1, MSR1, KLF6, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
intracellular organelle part (GO:0044446) 0.8112ZFHX3, BRCA2, MSR1, HOXB13, AR, CDH1, HIP1, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
intracellular organelle (GO:0043229) 0.5112ZFHX3, BRCA2, PTEN, HOXB13, AR, CDH1, HIP1, MXI1, FGFR4, KLF6, CHEK2, MAD1L1
intracellular membrane-bounded organelle (GO:0043231) 0.612ZFHX3, BRCA2, KLF6, HOXB13, AR, CDH1, MXI1, FGFR4, MAD1L1, PTEN, CHEK2, HIP1
organelle part (GO:0044422) 0.7912AR, BRCA2, MSR1, HOXB13, ZFHX3, CDH1, HIP1, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
cytoplasmic part (GO:0044444) 0.8210AR, BRCA2, EPHB2, CDH1, MSR1, FGFR4, MAD1L1, PTEN, CHEK2, HIP1
nucleus (GO:0005634) 1.0710ZFHX3, BRCA2, PTEN, HOXB13, AR, MXI1, HIP1, KLF6, CHEK2, MAD1L1
cytoplasm (GO:0005737) 1.019AR, BRCA2, ZFHX3, CDH1, HIP1, MXI1, FGFR4, PTEN, MAD1L1
membrane (GO:0016020) 0.689AR, BRCA2, CD82, HIP1, CDH1, MSR1, FGFR4, PTEN, EPHB2
nuclear part (GO:0044428) 1.559AR, BRCA2, HOXB13, ZFHX3, MXI1, FGFR4, PTEN, CHEK2, MAD1L1
membrane part (GO:0044425) 0.958AR, BRCA2, CD82, CDH1, MSR1, FGFR4, PTEN, EPHB2
nucleoplasm (GO:0005654) 1.897ZFHX3, BRCA2, HOXB13, AR, PTEN, CHEK2, FGFR4
protein complex (GO:0043234) 1.517ZFHX3, BRCA2, HOXB13, AR, CDH1, MSR1, MAD1L1
integral component of membrane (GO:0016021) 1.147AR, BRCA2, EPHB2, CDH1, MSR1, CD82, FGFR4
macromolecular complex (GO:0032991) 1.357ZFHX3, BRCA2, HOXB13, AR, CDH1, MSR1, MAD1L1
intrinsic component of membrane (GO:0031224) 1.137AR, BRCA2, EPHB2, CDH1, MSR1, CD82, FGFR4
non-membrane-bounded organelle (GO:0043228) 1.766ZFHX3, BRCA2, CDH1, MXI1, MAD1L1, HIP1
plasma membrane part (GO:0044459) 1.956EPHB2, PTEN, CDH1, MSR1, CD82, FGFR4
vesicle (GO:0031982) 1.646BRCA2, CD82, CDH1, FGFR4, MSR1, HIP1
intracellular non-membrane-bounded organelle (GO:0043232) 1.766ZFHX3, BRCA2, CDH1, MXI1, MAD1L1, HIP1
plasma membrane (GO:0005886) 1.396EPHB2, PTEN, CDH1, MSR1, CD82, FGFR4
cytosol (GO:0005829) 1.685MSR1, AR, MAD1L1, PTEN, EPHB2
membrane-bounded vesicle (GO:0031988) 1.715HIP1, FGFR4, BRCA2, CD82, CDH1
cytoskeleton (GO:0005856) 2.554HIP1, BRCA2, MAD1L1, CDH1
Golgi apparatus (GO:0005794) 2.74HIP1, CHEK2, FGFR4, CDH1
cytoplasmic vesicle (GO:0031410) 2.874MSR1, BRCA2, HIP1, FGFR4
extracellular region (GO:0005576) 2.184CDH1, FGFR4, PTEN, EPHB2
intracellular vesicle (GO:0097708) 2.864MSR1, BRCA2, HIP1, FGFR4
integral component of plasma membrane (GO:0005887) 2.574MSR1, FGFR4, EPHB2, CD82
chromosomal part (GO:0044427) 3.184AR, BRCA2, CHEK2, MAD1L1
intrinsic component of plasma membrane (GO:0031226) 2.534MSR1, FGFR4, EPHB2, CD82
nuclear body (GO:0016604) 3.943CHEK2, ZFHX3, PTEN
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.123BRCA2, HIP1, FGFR4
cytoskeletal part (GO:0044430) 2.493BRCA2, CDH1, MAD1L1
nucleoplasm part (GO:0044451) 3.223CHEK2, ZFHX3, PTEN
cell projection (GO:0042995) 2.473CDH1, PTEN, EPHB2
extracellular region part (GO:0044421) 1.573MSR1, CD82, CDH1
chromosomal region (GO:0098687) 4.193CHEK2, BRCA2, MAD1L1
cell-cell junction (GO:0005911) 3.852FGFR4, CDH1
cytoplasmic side of plasma membrane (GO:0009898) 6.02PTEN, CDH1
chromosome, telomeric region (GO:0000781) 4.92CHEK2, BRCA2
side of membrane (GO:0098552) 4.222PTEN, CDH1
cell junction (GO:0030054) 2.752FGFR4, CDH1
actin cytoskeleton (GO:0015629) 4.392MAD1L1, CDH1
PML body (GO:0016605) 5.242CHEK2, PTEN
extracellular exosome (GO:0070062) 1.892CD82, CDH1
nucleolus (GO:0005730) 3.062MXI1, ZFHX3
vacuole (GO:0005773) 2.922FGFR4, CDH1
centrosome (GO:0005813) 3.752BRCA2, MAD1L1
whole membrane (GO:0098805) 2.852MSR1, HIP1
microtubule organizing center (GO:0005815) 3.422BRCA2, MAD1L1
cytoplasmic vesicle part (GO:0044433) 3.412MSR1, HIP1
neuron part (GO:0097458) 2.642PTEN, EPHB2
neuron projection (GO:0043005) 3.122PTEN, EPHB2
cytoplasmic side of membrane (GO:0098562) 5.812PTEN, CDH1
bounding membrane of organelle (GO:0098588) 2.392MSR1, HIP1
cytoplasmic vesicle membrane (GO:0030659) 3.672MSR1, HIP1
vesicle membrane (GO:0012506) 3.632MSR1, HIP1
extracellular vesicle (GO:1903561) 1.892CD82, CDH1
organelle membrane (GO:0031090) 1.972MSR1, HIP1
extracellular organelle (GO:0043230) 1.892CD82, CDH1
transcription factor complex (GO:0005667) 4.12ZFHX3, HOXB13
endosome (GO:0005768) 3.252FGFR4, CDH1
nuclear chromosome part (GO:0044454) 3.672AR, BRCA2

NET-GE enrichment

Term New enriched termICP valueGenes
protein complex (GO:0043234) -1.510.001ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, MXI1, FGFR4, PTEN, HIP1, KLF6, CD82, CHEK2, MAD1L1
Schmidt-Lanterman incisure (GO:0043220) NEW7.320.004PTEN, CDH1
macromolecular complex (GO:0032991) -1.350.005ZFHX3, BRCA2, EPHB2, HOXB13, AR, CDH1, MSR1, MXI1, FGFR4, PTEN, HIP1, KLF6, CD82, CHEK2, MAD1L1
vesicle (GO:0031982) -1.640.006AR, BRCA2, EPHB2, HOXB13, HIP1, CDH1, MSR1, MXI1, PTEN, FGFR4, KLF6, CD82, CHEK2, MAD1L1
nucleolus (GO:0005730) -3.060.013AR, BRCA2, PTEN, CDH1, MXI1, KLF6, CHEK2, MAD1L1
cytoplasmic vesicle (GO:0031410) -2.870.007AR, BRCA2, CD82, CDH1, MSR1, MXI1, HIP1, PTEN, EPHB2
inclusion body (GO:0016234) NEW5.550.011AR, PTEN, CDH1
axon (GO:0030424) NEW4.150.021AR, PTEN, CDH1, EPHB2, CD82
nuclear chromosome part (GO:0044454) -3.670.0AR, BRCA2, KLF6, HOXB13, CDH1, PTEN, MAD1L1
cytoskeletal part (GO:0044430) -2.490.044EPHB2, BRCA2, KLF6, AR, CDH1, MXI1, HIP1, PTEN, CHEK2, MAD1L1
chromosomal part (GO:0044427) -3.180.026AR, BRCA2, KLF6, HOXB13, CDH1, PTEN, MAD1L1