Gene table of IDH1 : isocitrate dehydrogenase (NADP(+)) 1, cytosolic

Gene-disease associations table

Disease ID	Disease name	Source of annotation with IDH1	OMIM link	Number of associated genes	genes
PS137800	GLIOMA	OMIM	link to OMIM	8	PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Metabolic pathways	hsa01100	2.49
Carbon metabolism	hsa01200	6.03
Glutathione metabolism	hsa00480	6.96
Citrate cycle (TCA cycle)	hsa00020	7.86
Peroxisome	hsa04146	6.34
Biosynthesis of amino acids	hsa01230	6.58
Central carbon metabolism in cancer	hsa05230	6.7
2-Oxocarboxylic acid metabolism	hsa01210	8.68

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	R-HSA-2978092	12.98
Peroxisomal lipid metabolism	R-HSA-390918	8.59
Diseases of metabolism	R-HSA-5668914	6.57
Metabolism	R-HSA-1430728	2.34
NADPH regeneration	R-HSA-389542	12.98
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
NAD binding	GO:0051287	5.77
binding	GO:0005488	0.18
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
(R)-2-hydroxyglutarate dehydrogenase activity	GO:0051990	9.05
oxidoreductase activity	GO:0016491	3.12
coenzyme binding	GO:0050662	4.53
NADP binding	GO:0050661	5.93
magnesium ion binding	GO:0000287	4.41
ion binding	GO:0043167	1.36
nucleoside phosphate binding	GO:1901265	1.96
isocitrate dehydrogenase activity	GO:0004448	8.13
metal ion binding	GO:0046872	1.41
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
cation binding	GO:0043169	1.4
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
cofactor binding	GO:0048037	4.16
protein dimerization activity	GO:0046983	2.72
oxidoreductase activity, acting on CH-OH group of donors	GO:0016614	4.83
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0016616	5.0
organic cyclic compound binding	GO:0097159	1.05
isocitrate dehydrogenase (NADP+) activity	GO:0004450	9.05
protein binding	GO:0005515	0.46
receptor binding	GO:0005102	2.43