Gene table of ERBB2 : erb-b2 receptor tyrosine kinase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ERBB2	OMIM link	Number of associated genes	genes
613659	GASTRIC CANCER	OMIM	link to OMIM	9	KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS
PS137800	GLIOMA	ClinVar, OMIM	link to OMIM	8	PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53
211980	LUNG CANCER	OMIM	link to OMIM	17	RASSF1, PARK2, IRF1, CASP8, ERBB2, PPP2R1B, FASLG, MAP3K8, PIK3CA, BRAF, KRAS, DLEC1, SLC22A18, ERCC6, CYP2A6, MXRA5, EGFR

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Annotation of the gene ERBB2

Associated genes in ENSEMBL

ENSG00000141736

Associated proteins - SwissProt Accession ID

P04626

Associated PDB IDs

Cytogenetic Band

17q12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Bladder cancer	hsa05219	7.38
Proteoglycans in cancer	hsa05205	5.02
Endometrial cancer	hsa05213	6.81
Calcium signaling pathway	hsa04020	5.22
MicroRNAs in cancer	hsa05206	5.38
Pathways in cancer	hsa05200	3.98
Prostate cancer	hsa05215	6.11
Pancreatic cancer	hsa05212	6.56
Adherens junction	hsa04520	6.26
Non-small cell lung cancer	hsa05223	6.88
ErbB signaling pathway	hsa04012	6.15
Focal adhesion	hsa04510	4.92
HIF-1 signaling pathway	hsa04066	5.9
Central carbon metabolism in cancer	hsa05230	6.7

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85
Interleukin-2 signaling	R-HSA-451927	5.05
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
GAB1 signalosome	R-HSA-180292	6.31
Developmental Biology	R-HSA-1266738	3.48
Sema4D in semaphorin signaling	R-HSA-400685	8.23
Signaling by VEGF	R-HSA-194138	4.66
FCERI mediated MAPK activation	R-HSA-2871796	4.32
IRS-mediated signalling	R-HSA-112399	4.87
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
Signaling by EGFR	R-HSA-177929	4.59
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.4
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
PI3K/AKT activation	R-HSA-198203	6.32
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15
Frs2-mediated activation	R-HSA-170968	5.12
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signal transduction	R-HSA-186763	4.65
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Interleukin receptor SHC signaling	R-HSA-912526	5.09
Innate Immune System	R-HSA-168249	3.17
Semaphorin interactions	R-HSA-373755	6.92
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Prolonged ERK activation events	R-HSA-169893	5.11
Downregulation of ERBB2:ERBB3 signaling	R-HSA-1358803	9.28
Signaling by FGFR2	R-HSA-5654738	4.68
GRB2 events in EGFR signaling	R-HSA-179812	5.15
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
Axon guidance	R-HSA-422475	3.93
Signaling by Leptin	R-HSA-2586552	5.1
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05
IGF1R signaling cascade	R-HSA-2428924	4.85
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by Insulin receptor	R-HSA-74752	4.73
Disease	R-HSA-1643685	3.33
Insulin receptor signalling cascade	R-HSA-74751	4.85
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Immune System	R-HSA-168256	2.37
Signalling to RAS	R-HSA-167044	5.08
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
SHC1 events in EGFR signaling	R-HSA-180336	5.15
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15
ARMS-mediated activation	R-HSA-170984	5.12
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15
Signaling by PDGF	R-HSA-186797	4.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Signaling by Interleukins	R-HSA-449147	4.71
GRB7 events in ERBB2 signaling	R-HSA-1306955	10.66
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
SOS-mediated signalling	R-HSA-112412	5.15
Signaling by ERBB4	R-HSA-1236394	4.7
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
Adaptive Immune System	R-HSA-1280218	3.19
MAPK family signaling cascades	R-HSA-5683057	4.89
Signalling by NGF	R-HSA-166520	4.23
RAF/MAP kinase cascade	R-HSA-5673001	5.15
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
Signaling by SCF-KIT	R-HSA-1433557	4.73
NCAM signaling for neurite out-growth	R-HSA-375165	4.9
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Signaling by GPCR	R-HSA-372790	2.68
Signalling to ERKs	R-HSA-187687	5.04
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
Ras guanyl-nucleotide exchange factor activity	GO:0005088	4.31
protein C-terminus binding	GO:0008022	4.5
signaling receptor activity	GO:0038023	2.49
phosphatidylinositol 3-kinase activity	GO:0035004	5.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
guanyl-nucleotide exchange factor activity	GO:0005085	4.02
enzyme binding	GO:0019899	2.27
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
ATP binding	GO:0005524	2.43
molecular function regulator	GO:0098772	2.51
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	5.61
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
RNA polymerase binding	GO:0070063	6.15
receptor signaling protein activity	GO:0005057	4.76
growth factor binding	GO:0019838	4.89
nucleotide binding	GO:0000166	1.96
receptor signaling protein tyrosine kinase activity	GO:0004716	7.44
phosphatidylinositol bisphosphate kinase activity	GO:0052813	5.56
transferase activity	GO:0016740	1.95
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
ErbB-3 class receptor binding	GO:0043125	8.35
identical protein binding	GO:0042802	2.63
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
RNA polymerase I core binding	GO:0001042	9.05
purine nucleotide binding	GO:0017076	2.19
receptor binding	GO:0005102	2.43
protein heterodimerization activity	GO:0046982	3.64
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
RNA polymerase core enzyme binding	GO:0043175	6.6
ribonucleoside binding	GO:0032549	2.22
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
phosphatase binding	GO:0019902	4.63
adenyl ribonucleotide binding	GO:0032559	2.41
ribonucleotide binding	GO:0032553	2.19
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32