Disease table of GLIOMA OMIM ID: PS137800

Gene-disease associations table

Gene	Associated with GLIOMA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ERBB2	ClinVar, OMIM	HGNC link	17q12	3	PS137800, 613659, 211980
BRCA2	ClinVar, OMIM	HGNC link	13q13.1	8	PS227650, PS194070, 155255, 114480, 176807, PS137800, 613347, PS604370
TP53	ClinVar, OMIM	HGNC link	17p13.1	12	114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
PTEN	ClinVar, OMIM, HUMSAVAR	HGNC link	10q23.31	10	276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
IDH2	HUMSAVAR	HGNC link	15q26.1	2	PS137800, PS600721
IDH1	OMIM	HGNC link	2q34	1	PS137800
POT1	ClinVar, OMIM, HUMSAVAR	HGNC link	7q31.33	2	PS137800, PS155600
PPARG	ClinVar	HGNC link	3p25.2	5	601665, PS137800, 125853, 609338, PS151660

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
17	2	ERBB2, TP53

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TP53	YES	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	3	BRCA2, TP53, PTEN
PPARG	YES	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	TP53, PTEN
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	ERBB2, PTEN
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	3	PPARG, TP53, PTEN
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	2	PPARG, TP53
PAX2	NO	7	WT1, L1CAM, TP53, ERBB2, ADAM10, NCAM1, SFRP2	2	ERBB2, TP53
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	2	ERBB2, PTEN
HDAC1	NO	64	NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B	2	BRCA2, TP53
YY1	NO	74	FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A2	2	ERBB2, TP53
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	TP53, PTEN
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	PPARG, TP53
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	BRCA2, TP53, PTEN
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	BRCA2, TP53, PTEN
ELF1	NO	10	FCER1A, BRCA2, TLR9, FLI1, ERBB2, DNTT, CYBB, MEIS1, TEK, CD68	2	ERBB2, BRCA2
TFAP2A	NO	69	SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH1	2	ERBB2, PTEN
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	2	PPARG, TP53

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ERBB2	YES	30	AR, WWP1, ECD, TFAP2A, PAX2, MYB, PURA, PGR, JUND, SP1, ETV4, GATA4, NCOA3, CREB1, VDR, TFAP2B, ATF7, ELK1, FOXP3, ATF1, EP300, ELF1, GABPA, YY1, XRCC6, TFAP2C, YBX1, SP3, SP4, XRCC5	0
BRCA2	YES	11	ESR2, CTBP1, HDAC1, ELF1, TP53, USF2, RELA, PARP1, BRCA1, NFKB1, USF1	1	TP53
TP53	YES	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	2	PPARG, TP53
PTEN	YES	15	SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF	2	PPARG, TP53
PPARG	YES	14	NCOR1, UHRF1, SREBF1, EGR1, SREBF2, CDX1, RB1, CEBPD, SIRT1, NR4A3, KLF2, E2F1, GATA2, STAT1	0
BCL2L1	NO	19	STAT5B, NR1I2, STAT3, NUPR1, BCL11B, SREBF1, FOS, MTA1, NFKB1, STAT5A, TP53, CEBPB, JUN, PAX3, STAT6, PGR, RELA, PPARG, BCL6	2	PPARG, TP53
CAV1	NO	6	SP1, GATA6, SREBF1, TFDP1, TP53, PPARG	2	PPARG, TP53
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	PPARG, TP53
BCL2	NO	43	ATM, ING4, ERCC2, TBP, TP53, TWIST1, CREB1, MYB, SIM2, PGR, PAX5, SP1, CEBPA, ATF5, MSX2, NCOA3, GLI2, NR1I2, HOXA1, GLI1, TFAP2A, E2F1, DEK, WT1, ATF1, ING2, SATB1, PER1, ABL1, PARP1, NFKB1, MYC, DDB2, STAT3, BACH2, ZBTB16, RELA, ZNRD1, ESR1, PAWR, PPARG, IRF1, FOXA1	2	PPARG, TP53
GDF15	NO	7	TWIST2, EGR1, KLF4, ATF3, TWIST1, TP53, PPARG	2	PPARG, TP53
EGFR	NO	30	AR, BCL3, WWP1, NR3C2, TFAP2A, PGR, NFKB2, SP1, EGR1, PML, HDAC3, MTA1, BRCA1, WT1, VDR, HOXB7, JUN, TP53, RELA, LRRFIP1, NFKB1, STAT1, STAT3, YY1, YBX1, ESR1, JUNB, PPARG, CREBBP, TSG101	2	PPARG, TP53
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	2	PPARG, TP53
CCND1	NO	62	POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX6	2	PPARG, TP53
MMP1	NO	24	MAZ, RFWD2, TWIST1, FOSL1, NFKBIA, ETS2, FOS, PAX5, ETV4, BACH1, CITED2, ETV3, NR4A2, JUN, TP53, RELA, ZNF410, NFKB1, ETS1, STAT3, GATA3, FLI1, CEBPB, PPARG	2	PPARG, TP53

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ERBB2	TP53	No	24	ABL1, SUPT6H, PIN1, MUC1, CLTC, TFRC, CRK, PTK2, SOCS1, STUB1, KPNB1, SRPK1, ACTB, HSP90AA1, IRS4, SRC, HSP82, HSP90B1, IGF1R, HSPA4, PPP1R13B, ESR1, PLCG2, ERBB4
ERBB2	PTEN	No	11	HSP90AA1, IRS4, PC, CBL, PTK2, JUP, STUB1, ESR1, CTNNB1, PTK2B, CRKL
ERBB2	IDH2	No	1	EGFR
ERBB2	IDH1	No	2	NXF1, ANXA6
ERBB2	POT1	No	3	CRK, ACTB, STUB1
ERBB2	PPARG	No	5	MUC1, EGFR, CTNNB1, XPO1, PIN1
BRCA2	TP53	Yes	26	KAT2B, ATM, BRE, TP53, AURKB, CCNA2, SP1, ATR, BACH1, RAD23A, PSMD6, RPA1, SMAD3, BRCA1, BARD1, SMAD2, PCNA, H2AFX, BRCC3, CDK2, FLNA, USP11, PLK1, SERPINH1, CHEK2, RAD51
BRCA2	PTEN	No	3	KAT2B, NEDD4, TP53
BRCA2	IDH2	No	1	CDK2
BRCA2	IDH1	No	1	CDK2
BRCA2	PPARG	No	6	SP1, SMAD2, STAT5A, SMAD3, SERPINH1, NEDD4
TP53	PTEN	Yes	73	KAT2B, TXN, HSPA1A, TUBB4B, HSP90AB1, SLC25A5, G3BP2, S100A8, USP10, TP53, RPS9, TUBA1C, RPS6, BMI1, LIMA1, ATP5A1, MVP, DDB1, HSP90AA1, RPS27A, EEF2, USP39, EGR1, PARK7, FZR1, NCOA3, PTK2, ANG, RPL12, DBN1, HSPA1L, HSPA2, ESR1, POLDIP2, RPL27, UTP14A, RPL14, RPL10A, RPS3, RPLP0, TUBB2A, RPS25, USP7, ELAVL1, RPS4X, RPS26, RPS17, IRS4, HSPA8, PPP3CA, STUB1, ETS1, MYO1C, RPLP2, CASP8, SKP1, RPS27, CSNK2A1, DNAJA1, ANXA2, RPL7, PPP1CA, TUBB, HNRNPU, HSPA6, AKAP12, RPS13, UBC, RPL31, UBE2I, RPL13, RPL23, RPS2
TP53	IDH2	No	4	UBC, HDAC1, IDH3B, CDK2
TP53	IDH1	No	9	CDK2, ETHE1, PCBP1, RBBP7, ELAVL1, ZHX1, UBC, IDH3B, MOV10
TP53	POT1	No	30	TUBB2A, RPS6, RPS7, PCBP1, RPS8, YWHAE, HSPA1A, THRAP3, RPS19, MVP, TUBB4B, CALD1, CRK, YTHDF1, DNAJB1, STUB1, DBN1, CSNK2B, PCMT1, S100A8, MDM2, GAPDH, PRKDC, HSP90AB1, ACTB, XRCC6, DDX3X, ANXA2, CREBBP, RPS2
TP53	PPARG	No	43	KAT2A, PIAS1, TRIM24, MDM2, MAPK1, TFAP2A, PIN1, KAT5, STAT6, CDK5, NCOR1, SP1, TCF4, ASH2L, KLF5, NCOA3, RBBP5, COPS5, MUC1, NCOA2, SMAD3, PPARGC1A, SERPINH1, VDR, HDAC1, SMAD2, MED1, NCOA1, RELA, EP300, USP7, NR0B2, NR3C1, CREBBP, XRCC6, IKBKB, RB1, HMGA1, SMARCA4, UBC, NR4A1, UBE2I, PML
PTEN	IDH2	No	1	UBC
PTEN	IDH1	No	4	UBC, NME1, ARF4, ELAVL1
PTEN	POT1	No	16	TUBB4B, TUBB2A, RPS6, SPTAN1, S100A8, ANXA2, HSPA1A, TNKS, CFL1, MVP, HSP90AB1, LDHB, RPS2, STIP1, STUB1, DBN1
PTEN	PPARG	No	7	USP7, NCOA3, CAV1, CTNNB1, UBC, UBE2I, NEDD4
IDH2	IDH1	Yes	6	CDK2, IDH3G, UBC, NTRK1, IDH3A, IDH3B
IDH2	PPARG	No	3	UBC, HDAC1, EGFR
IDH1	POT1	No	3	PCBP1, PEX5, SBDS
IDH1	PPARG	No	2	UBC, PHB2
POT1	PPARG	No	6	SFPQ, MDM2, CREBBP, XRCC6, BCAS2, YWHAG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ERBB2	BRCA2	No	-	2	AR, TP53
ERBB2	TP53	Yes	activation, binding	57	BCL2L1, EGFR, IGF1R, NCOA3, WWOX, PTK6, MMP9, PIK3CA, PIN1, HBEGF, NOTCH3, UBB, STUB1, PTGS2, ANXA2, RPS27A, HGF, MAPK8, CCND1, SMAD7, PTK2, CLU, CD44, COPS5, MUC1, DNAJA3, LEP, UBA52, NOTCH1, BIRC5, MCL1, AR, HRAS, EFNB1, BNIP3L, ELAVL1, HSP90AA1, UBC, MMP1, CDH1, FOXM1, VEGFA, TFF2, STAT3, KRAS, TGFA, PTPN11, PTK2B, HSPA4, IL6, ERBB4, ESR1, MAX, MYC, YY1, HIF1A, PDCD4
ERBB2	PTEN	No	-	35	AR, EGFR, FOXM1, TP53, PIK3CA, PIK3CG, PDGFB, INS, MAPK8, PLXNB1, NCOA3, PTK2, IL8, SOS1, SHC1, BIRC5, CDH1, PIK3CB, GRB2, PIK3R3, SRC, VEGFA, LEP, NOTCH1, IGF1R, CBL, SPRY2, PIK3R1, HIF1A, ESR1, UBC, PIK3CD, CCND1, PIK3R5, RAC3
ERBB2	IDH2	No	-	1	UBC
ERBB2	IDH1	No	-	1	UBC
ERBB2	PPARG	No	-	16	PTGS2, RPS27A, PGR, ESR2, MAPK8, NCOA3, AR, TP53, INS, MMP1, CDH1, ESR1, UBC, LEP, VEGFA, MUC1
BRCA2	TP53	Yes	activation, binding	20	AURKB, AR, STAT5A, TREX1, CDK2, CDK4, BCCIP, CHEK1, ATR, RPA1, BLM, SMAD3, PLK1, RPA3, SNAI2, CHEK2, H2AFX, BRCA1, RAD51, MLH1
BRCA2	PTEN	No	-	3	AR, SMAD3, TP53
BRCA2	POT1	No	-	1	HIST3H3
BRCA2	PPARG	No	-	3	STAT5A, AR, TP53
TP53	PTEN	Yes	activation	65	KAT2B, TXN, EPHB4, FOXM1, THBS1, ZBTB16, SNAI1, CDKN1A, SMAD4, MMP2, CAV1, CREB1, PIK3CA, EGFR, HDAC9, FOS, BMI1, SMARCA4, NRP2, SP1, MAPK8, EGR1, PARK7, NCOA3, MTA1, PTK2, MTA3, PTP4A3, SMAD3, TGFB1, TGM2, UBE2I, BIRC5, ESR1, TSC2, AR, NGFR, NOTCH1, CDH1, IL17A, IKBKB, AKT1, VEGFA, PBK, FOXO3, CSNK2A1, USP7, BAX, SUMO1, BCL2, PPARG, PLK3, STK11, JUN, MTOR, EZH2, LEP, IGFBP2, MAPK14, UBC, APEX1, CCND1, FBXW7, IGF1R, HIF1A
TP53	IDH2	No	-	2	UBC, SIRT3
TP53	IDH1	No	-	1	UBC
TP53	POT1	No	-	3	STAG2, TERF2, TERT
TP53	PPARG	Yes	activation, binding	66	PRKAA2, RBBP5, IVL, MUC1, MMP1, AR, PRKAA1, CDK8, SERPINE1, CTGF, CDK5, ASH2L, VEGFA, TXNIP, PTGS2, RPS27A, E2F4, SUMO1, NFKB1, KLF5, NCOA3, RB1, NFATC2, SPP1, STAT5A, NCOR1, FOXO1, TGFB1, LEP, PTEN, HDAC1, SIRT1, SP1, PPARGC1A, NR2F2, ESR1, VDR, NR4A2, MAPK8, SMAD2, IL17A, FOS, NFE2L2, NR4A1, CDH1, RELA, MTOR, ICAM1, EP300, NR0B2, SLC2A4, CREBBP, MED1, CCL2, IGFBP3, GADD45A, BHLHE40, HMGA1, KLF2, SETDB1, UBC, PAPPA, HMOX1, MAF, KLF4, HNF4A
PTEN	IDH2	No	-	1	UBC
PTEN	IDH1	No	-	1	UBC
PTEN	PPARG	Yes	activation, binding	21	SP1, INS, MAPK8, SUMO1, UBC, AR, MTOR, NCOA3, RPTOR, TP53, IL17A, SCD, RPS6KB1, ATF2, CDH1, ESR1, TGFB1, LEP, FOS, VEGFA, ABCG2
IDH2	IDH1	No	-	11	UEVLD, LDHAL6B, MDH1B, MDH1, LDHAL6A, LDHC, UBC, IDH3A, IDH3B, LDHA, LDHB
IDH2	PPARG	No	-	1	UBC
IDH1	PPARG	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
BRCA2	TP53	No	-	2	BARD1, RAD51

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TP53	PPARG	No	1	CREBBP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	5	PPARG, ERBB2, BRCA2, TP53, PTEN
Central carbon metabolism in cancer	hsa05230	6.7	4	TP53, ERBB2, IDH1, PTEN
Pancreatic cancer	hsa05212	6.56	3	ERBB2, BRCA2, TP53
Endometrial cancer	hsa05213	6.81	3	ERBB2, TP53, PTEN
MicroRNAs in cancer	hsa05206	5.38	3	ERBB2, TP53, PTEN
Prostate cancer	hsa05215	6.11	3	ERBB2, TP53, PTEN
Melanoma	hsa05218	6.56	2	TP53, PTEN
Bladder cancer	hsa05219	7.38	2	ERBB2, TP53
Small cell lung cancer	hsa05222	6.17	2	TP53, PTEN
Proteoglycans in cancer	hsa05205	5.02	2	ERBB2, TP53
Metabolic pathways	hsa01100	2.49	2	IDH1, IDH2
Thyroid cancer	hsa05216	7.48	2	PPARG, TP53
Glioma	hsa05214	6.66	2	TP53, PTEN
p53 signaling pathway	hsa04115	6.56	2	TP53, PTEN
Carbon metabolism	hsa01200	6.03	2	IDH1, IDH2
Glutathione metabolism	hsa00480	6.96	2	IDH1, IDH2
Citrate cycle (TCA cycle)	hsa00020	7.86	2	IDH1, IDH2
Focal adhesion	hsa04510	4.92	2	ERBB2, PTEN
Peroxisome	hsa04146	6.34	2	IDH1, IDH2
Biosynthesis of amino acids	hsa01230	6.58	2	IDH1, IDH2
Non-small cell lung cancer	hsa05223	6.88	2	ERBB2, TP53
Huntington's disease	hsa05016	5.17	2	PPARG, TP53
Transcriptional misregulation in cancer	hsa05202	5.21	2	PPARG, TP53
Hepatitis B	hsa05161	5.52	2	TP53, PTEN
2-Oxocarboxylic acid metabolism	hsa01210	8.68	2	IDH1, IDH2
PI3K-Akt signaling pathway	hsa04151	4.21	2	TP53, PTEN

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Melanoma (hsa05218)	-	6.56	0.001	ERBB2, PPARG, TP53, PTEN
Pancreatic cancer (hsa05212)	-	6.56	0.025	ERBB2, BRCA2, TP53
Endometrial cancer (hsa05213)	-	6.81	0.013	ERBB2, TP53, PTEN
MAPK signaling pathway (hsa04010)	NEW	4.63	0.012	ERBB2, PTEN, PPARG, POT1, TP53
Thyroid cancer (hsa05216)	-	7.48	0.049	PPARG, TP53
Glioma (hsa05214)	-	6.66	0.017	ERBB2, TP53, PTEN
Prostate cancer (hsa05215)	-	6.11	0.008	ERBB2, TP53, PTEN
Metabolism of other amino acids	NEW	5.87	0.0	PPARG, IDH1, POT1, TP53, IDH2
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.0	TP53, ERBB2, IDH1, PTEN
FoxO signaling pathway (hsa04068)	NEW	5.63	0.027	ERBB2, PPARG, TP53, PTEN
Peroxisome (hsa04146)	-	6.34	0.032	IDH1, POT1, IDH2
Chemokine signaling pathway (hsa04062)	NEW	5.19	0.041	ERBB2, PPARG, PTEN, TP53
Citrate cycle (TCA cycle) (hsa00020)	-	7.86	0.029	IDH1, IDH2
Cancers: Overview	NEW	2.72	0.006	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
Cancers: Specific types	NEW	4.1	0.001	BRCA2, ERBB2, PPARG, PTEN, TP53
MicroRNAs in cancer (hsa05206)	-	5.38	0.035	ERBB2, TP53, PTEN
NOD-like receptor signaling pathway (hsa04621)	NEW	6.88	0.022	PPARG, PTEN, TP53
Pathways in cancer (hsa05200)	-	3.98	0.001	PPARG, ERBB2, BRCA2, TP53, PTEN
Non-small cell lung cancer (hsa05223)	-	6.88	0.02	ERBB2, PPARG, TP53
Chronic myeloid leukemia (hsa05220)	NEW	6.48	0.029	ERBB2, TP53, PTEN
p53 signaling pathway (hsa04115)	-	6.56	0.029	PPARG, PTEN, TP53
Carbohydrate metabolism	NEW	4.36	0.018	IDH2, IDH1, PPARG, POT1, PTEN
2-Oxocarboxylic acid metabolism (hsa01210)	-	8.68	0.03	IDH1, IDH2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	4	IDH1, PPARG, IDH2, PTEN
Generic Transcription Pathway	R-HSA-212436	3.86	3	PPARG, TP53, PTEN
Gene Expression	R-HSA-74160	2.72	3	PPARG, PTEN, TP53
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	3	IDH1, PPARG, PTEN
Disease	R-HSA-1643685	3.33	3	ERBB2, IDH1, PTEN
Cell Cycle	R-HSA-1640170	3.89	3	BRCA2, POT1, TP53
Signal Transduction	R-HSA-162582	1.78	3	ERBB2, TP53, PTEN
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	2	TP53, PTEN
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.15	2	POT1, TP53
PI3K/AKT activation	R-HSA-198203	6.32	2	ERBB2, PTEN
Cellular Senescence	R-HSA-2559583	5.7	2	POT1, TP53
Immune System	R-HSA-168256	2.37	2	ERBB2, PTEN
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	2	ERBB2, PTEN
Downstream signal transduction	R-HSA-186763	4.65	2	ERBB2, PTEN
GAB1 signalosome	R-HSA-180292	6.31	2	ERBB2, PTEN
Signaling by ERBB4	R-HSA-1236394	4.7	2	ERBB2, PTEN
Adaptive Immune System	R-HSA-1280218	3.19	2	ERBB2, PTEN
Developmental Biology	R-HSA-1266738	3.48	2	ERBB2, PPARG
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	2	ERBB2, PTEN
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	ERBB2, PTEN
PIP3 activates AKT signaling	R-HSA-1257604	6.37	2	ERBB2, PTEN
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	2	ERBB2, PTEN
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	2	ERBB2, PTEN
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	2	ERBB2, PTEN
Cellular responses to stress	R-HSA-2262752	4.56	2	POT1, TP53
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	2	ERBB2, PTEN
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	ERBB2, PTEN
Signaling by FGFR4	R-HSA-5654743	4.69	2	ERBB2, PTEN
Signaling by FGFR3	R-HSA-5654741	4.69	2	ERBB2, PTEN
Signaling by FGFR	R-HSA-190236	4.67	2	ERBB2, PTEN
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	2	ERBB2, PTEN
Diseases of signal transduction	R-HSA-5663202	4.89	2	ERBB2, PTEN
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	ERBB2, PTEN
Innate Immune System	R-HSA-168249	3.17	2	ERBB2, PTEN
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	ERBB2, PTEN
Signaling by PDGF	R-HSA-186797	4.53	2	ERBB2, PTEN
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	2	ERBB2, PTEN
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	2	ERBB2, PTEN
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	ERBB2, PTEN
Signaling by EGFR	R-HSA-177929	4.59	2	ERBB2, PTEN
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	ERBB2, PTEN
Signalling by NGF	R-HSA-166520	4.23	2	ERBB2, PTEN
Signaling by FGFR2	R-HSA-5654738	4.68	2	ERBB2, PTEN
Signaling by FGFR1	R-HSA-5654736	4.69	2	ERBB2, PTEN
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	2	ERBB2, PTEN
Meiosis	R-HSA-1500620	6.59	2	BRCA2, POT1
DAP12 interactions	R-HSA-2172127	4.56	2	ERBB2, PTEN
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	ERBB2, PTEN
Signaling by ERBB2	R-HSA-1227986	4.66	2	ERBB2, PTEN
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	2	TP53, PTEN
DAP12 signaling	R-HSA-2424491	4.64	2	ERBB2, PTEN

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
RHO GTPase Effectors (R-HSA-195258)	NEW	4.94	0.013	ERBB2, PTEN, PPARG, POT1, TP53
Meiosis (R-HSA-1500620)	-	6.59	0.037	BRCA2, POT1, TP53
Phospholipid metabolism (R-HSA-1483257)	NEW	5.83	0.0	ERBB2, PTEN, PPARG, POT1, TP53
Cell Cycle (R-HSA-1640170)	-	3.89	0.007	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.037	ERBB2, PPARG, TP53, PTEN
Metabolism of lipids and lipoproteins (R-HSA-556833)	-	3.79	0.005	IDH1, IDH2, POT1, TP53, ERBB2, PTEN, PPARG
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)	NEW	5.88	0.028	BRCA2, ERBB2, PPARG, TP53

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
organic cyclic compound binding (GO:0097159)	1.05	7	IDH1, BRCA2, IDH2, POT1, TP53, ERBB2, PPARG
heterocyclic compound binding (GO:1901363)	1.06	7	IDH1, BRCA2, IDH2, POT1, TP53, ERBB2, PPARG
protein binding (GO:0005515)	0.46	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
enzyme binding (GO:0019899)	2.27	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cation binding (GO:0043169)	1.4	5	IDH2, IDH1, PPARG, TP53, PTEN
ion binding (GO:0043167)	1.36	5	TP53, IDH1, PPARG, IDH2, PTEN
catalytic activity (GO:0003824)	1.05	5	ERBB2, PTEN, BRCA2, IDH1, IDH2
receptor binding (GO:0005102)	2.43	5	ERBB2, PTEN, PPARG, IDH1, TP53
metal ion binding (GO:0046872)	1.41	5	IDH2, IDH1, PPARG, TP53, PTEN
identical protein binding (GO:0042802)	2.63	5	TP53, ERBB2, PPARG, IDH1, PTEN
small molecule binding (GO:0036094)	1.89	4	TP53, ERBB2, IDH1, IDH2
DNA binding (GO:0003677)	1.92	4	BRCA2, PPARG, POT1, TP53
nucleoside phosphate binding (GO:1901265)	1.96	4	TP53, ERBB2, IDH1, IDH2
nucleic acid binding (GO:0003676)	1.44	4	BRCA2, PPARG, POT1, TP53
nucleotide binding (GO:0000166)	1.96	4	TP53, ERBB2, IDH1, IDH2
sequence-specific DNA binding (GO:0043565)	2.79	3	PPARG, POT1, TP53
magnesium ion binding (GO:0000287)	4.41	3	IDH1, PTEN, IDH2
protein phosphatase binding (GO:0019903)	4.93	3	ERBB2, PPARG, TP53
phosphatase binding (GO:0019902)	4.63	3	ERBB2, PPARG, TP53
macromolecular complex binding (GO:0044877)	2.61	3	PPARG, TP53, PTEN
protein dimerization activity (GO:0046983)	2.72	3	ERBB2, IDH1, TP53
signaling receptor activity (GO:0038023)	2.49	2	ERBB2, PPARG
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	ERBB2, TP53
NAD binding (GO:0051287)	5.77	2	IDH1, IDH2
molecular transducer activity (GO:0060089)	2.32	2	ERBB2, PPARG
zinc ion binding (GO:0008270)	2.66	2	PPARG, TP53
signal transducer activity (GO:0004871)	2.28	2	ERBB2, PPARG
molecular function regulator (GO:0098772)	2.51	2	ERBB2, POT1
purine nucleoside binding (GO:0001883)	2.22	2	ERBB2, TP53
oxidoreductase activity (GO:0016491)	3.12	2	IDH1, IDH2
coenzyme binding (GO:0050662)	4.53	2	IDH1, IDH2
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	PPARG, TP53
transition metal ion binding (GO:0046914)	2.48	2	PPARG, TP53
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	2	PPARG, TP53
transferase activity (GO:0016740)	1.95	2	ERBB2, BRCA2
ribonucleotide binding (GO:0032553)	2.19	2	ERBB2, TP53
protease binding (GO:0002020)	5.08	2	BRCA2, TP53
ribonucleoside binding (GO:0032549)	2.22	2	ERBB2, TP53
receptor activity (GO:0004872)	2.32	2	ERBB2, PPARG
purine nucleotide binding (GO:0017076)	2.19	2	ERBB2, TP53
double-stranded DNA binding (GO:0003690)	3.09	2	PPARG, TP53
nucleoside binding (GO:0001882)	2.21	2	ERBB2, TP53
single-stranded DNA binding (GO:0003697)	5.17	2	BRCA2, POT1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	2	PPARG, TP53
transcription factor binding (GO:0008134)	3.46	2	PPARG, TP53
regulatory region nucleic acid binding (GO:0001067)	3.03	2	PPARG, TP53
lipid binding (GO:0008289)	3.26	2	PPARG, PTEN
protein kinase binding (GO:0019901)	3.44	2	TP53, PTEN
kinase binding (GO:0019900)	3.32	2	TP53, PTEN
cofactor binding (GO:0048037)	4.16	2	IDH1, IDH2
core promoter binding (GO:0001047)	4.71	2	PPARG, TP53
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	PPARG, TP53
isocitrate dehydrogenase activity (GO:0004448)	8.13	2	IDH1, IDH2
transcription regulatory region DNA binding (GO:0044212)	3.03	2	PPARG, TP53
chromatin binding (GO:0003682)	3.64	2	PPARG, TP53
oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)	4.83	2	IDH1, IDH2
adenyl ribonucleotide binding (GO:0032559)	2.41	2	ERBB2, TP53
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	5.0	2	IDH1, IDH2
cytoskeletal protein binding (GO:0008092)	3.02	2	BRCA2, PPARG
carbohydrate derivative binding (GO:0097367)	2.03	2	ERBB2, TP53
adenyl nucleotide binding (GO:0030554)	2.4	2	ERBB2, TP53
isocitrate dehydrogenase (NADP+) activity (GO:0004450)	9.05	2	IDH1, IDH2
transmembrane signaling receptor activity (GO:0004888)	2.57	2	ERBB2, PPARG
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	PPARG, TP53
ATP binding (GO:0005524)	2.43	2	ERBB2, TP53
regulatory region DNA binding (GO:0000975)	3.03	2	PPARG, TP53
purine ribonucleotide binding (GO:0032555)	2.2	2	ERBB2, TP53
protein heterodimerization activity (GO:0046982)	3.64	2	ERBB2, TP53
purine ribonucleoside binding (GO:0032550)	2.22	2	ERBB2, TP53
transmembrane receptor activity (GO:0099600)	2.53	2	ERBB2, PPARG
nucleic acid binding transcription factor activity (GO:0001071)	2.65	2	PPARG, TP53

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	NEW	4.14	0.002	PPARG, ERBB2, POT1, TP53, PTEN
protein C-terminus binding (GO:0008022)	NEW	4.5	0.034	ERBB2, PPARG, PTEN, TP53
transcription corepressor activity (GO:0003714)	NEW	4.33	0.002	ERBB2, PTEN, PPARG, IDH1, TP53
kinase regulator activity (GO:0019207)	NEW	4.5	0.011	ERBB2, POT1, TP53, PTEN
NAD binding (GO:0051287)	-	5.77	0.006	IDH1, TP53, IDH2
kinase activator activity (GO:0019209)	NEW	5.58	0.016	ERBB2, POT1, PTEN
enzyme binding (GO:0019899)	-	2.27	0.001	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
phosphoric ester hydrolase activity (GO:0042578)	NEW	3.82	0.012	PPARG, ERBB2, POT1, TP53, PTEN
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	NEW	4.31	0.016	ERBB2, PPARG, TP53, PTEN
protein dimerization activity (GO:0046983)	-	2.72	0.032	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	NEW	3.88	0.024	ERBB2, PPARG, TP53, PTEN
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.027	ERBB2, PTEN, PPARG, POT1, TP53
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (GO:0001078)	NEW	5.08	0.026	ERBB2, PPARG, TP53
NADP binding (GO:0050661)	NEW	5.93	0.005	IDH1, TP53, IDH2
nucleoside phosphate binding (GO:1901265)	-	1.96	0.045	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
oxidoreductase activity (GO:0016491)	-	3.12	0.001	IDH1, IDH2, POT1, TP53, ERBB2, PTEN, PPARG
coenzyme binding (GO:0050662)	-	4.53	0.018	TP53, ERBB2, IDH1, IDH2
structure-specific DNA binding (GO:0043566)	NEW	4.98	0.002	BRCA2, PTEN, PPARG, POT1, TP53
growth factor activity (GO:0008083)	NEW	4.66	0.018	ERBB2, PPARG, PTEN, TP53
hormone binding (GO:0042562)	NEW	5.53	0.022	PPARG, PTEN, TP53
isocitrate dehydrogenase (NADP+) activity (GO:0004450)	-	9.05	0.0	IDH1, IDH2
receptor signaling protein activity (GO:0005057)	NEW	4.76	0.004	ERBB2, POT1, TP53, PTEN
magnesium ion binding (GO:0000287)	-	4.41	0.021	IDH2, ERBB2, IDH1, PTEN
sequence-specific DNA binding (GO:0043565)	-	2.79	0.021	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
nucleotide binding (GO:0000166)	-	1.96	0.045	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
actin binding (GO:0003779)	NEW	3.74	0.013	PPARG, ERBB2, POT1, TP53, PTEN
fatty acid binding (GO:0005504)	NEW	6.37	0.002	PPARG, POT1, TP53
isocitrate dehydrogenase activity (GO:0004448)	-	8.13	0.001	IDH1, IDH2
active transmembrane transporter activity (GO:0022804)	NEW	3.85	0.041	ERBB2, PPARG, IDH1, TP53
protein homodimerization activity (GO:0042803)	NEW	3.16	0.002	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
solute (GO:0015294)	NEW	5.15	0.017	ERBB2, PPARG, TP53
tubulin binding (GO:0015631)	NEW	4.1	0.003	POT1, ERBB2, BRCA2, TP53, PTEN
cytokine activity (GO:0005125)	NEW	4.34	0.043	ERBB2, PPARG, PTEN, TP53
protein tyrosine/serine/threonine phosphatase activity (GO:0008138)	NEW	5.91	0.004	ERBB2, TP53, PTEN
protein kinase regulator activity (GO:0019887)	NEW	4.6	0.005	ERBB2, POT1, TP53, PTEN
transcription factor binding (GO:0008134)	-	3.46	0.048	ERBB2, PTEN, PPARG, POT1, TP53
nuclear hormone receptor binding (GO:0035257)	NEW	4.7	0.002	PPARG, POT1, TP53, PTEN
protein binding, bridging (GO:0030674)	NEW	4.68	0.009	ERBB2, POT1, TP53, PTEN
ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374)	NEW	5.77	0.003	PPARG, PTEN, TP53
core promoter proximal region sequence-specific DNA binding (GO:0000987)	NEW	3.83	0.027	ERBB2, PPARG, PTEN, TP53
phosphatase binding (GO:0019902)	-	4.63	0.007	ERBB2, POT1, TP53, PTEN
cofactor binding (GO:0048037)	-	4.16	0.003	TP53, ERBB2, POT1, IDH1, IDH2
core promoter proximal region DNA binding (GO:0001159)	NEW	3.82	0.027	ERBB2, PPARG, PTEN, TP53
hormone receptor binding (GO:0051427)	NEW	4.57	0.008	PPARG, POT1, TP53, PTEN
monocarboxylic acid binding (GO:0033293)	NEW	5.61	0.016	PPARG, POT1, TP53
iron ion binding (GO:0005506)	NEW	4.65	0.014	ERBB2, PPARG, POT1, TP53
protein kinase activator activity (GO:0030295)	NEW	5.68	0.012	ERBB2, POT1, PTEN
amino acid binding (GO:0016597)	NEW	5.71	0.003	ERBB2, POT1, TP53, PTEN
binding, bridging (GO:0060090)	NEW	4.57	0.014	ERBB2, POT1, TP53, PTEN
phospholipid binding (GO:0005543)	NEW	3.91	0.014	PPARG, ERBB2, POT1, TP53, PTEN
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription (GO:0001227)	NEW	4.61	0.001	ERBB2, PPARG, TP53, PTEN
transmembrane receptor protein kinase activity (GO:0019199)	NEW	5.32	0.034	ERBB2, TP53, PTEN
oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)	-	4.83	0.002	IDH1, POT1, TP53, IDH2
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	-	5.0	0.001	IDH1, POT1, TP53, IDH2
dioxygenase activity (GO:0051213)	NEW	5.25	0.045	PPARG, POT1, TP53
cytoskeletal protein binding (GO:0008092)	-	3.02	0.042	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
organic acid binding (GO:0043177)	NEW	6.6	0.001	ERBB2, PTEN, PPARG, POT1, TP53
RNA polymerase core enzyme binding (GO:0043175)	NEW	6.6	0.018	ERBB2, TP53
carboxylic acid binding (GO:0031406)	NEW	4.64	0.001	ERBB2, PTEN, PPARG, POT1, TP53
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.048	ERBB2, PPARG, PTEN, TP53
signaling adaptor activity (GO:0035591)	NEW	5.43	0.017	ERBB2, POT1, TP53
transmembrane transporter activity (GO:0022857)	NEW	2.82	0.038	IDH1, POT1, TP53, ERBB2, PTEN, PPARG
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.013	ERBB2, PTEN, PPARG, POT1, TP53
receptor binding (GO:0005102)	-	2.43	0.017	ERBB2, PTEN, PPARG, IDH1, TP53
protein heterodimerization activity (GO:0046982)	-	3.64	0.004	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
endopeptidase activity (GO:0004175)	NEW	3.63	0.034	PPARG, ERBB2, POT1, TP53, PTEN

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
primary metabolic process (GO:0044238)	0.69	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cellular process (GO:0009987)	0.26	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
metabolic process (GO:0008152)	0.58	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cellular metabolic process (GO:0044237)	0.69	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
organic substance metabolic process (GO:0071704)	0.63	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
regulation of primary metabolic process (GO:0080090)	1.08	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of metabolic process (GO:0019222)	1.02	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of cellular biosynthetic process (GO:0031326)	1.38	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of cellular metabolic process (GO:0031323)	1.07	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of biosynthetic process (GO:0009889)	1.37	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of cellular process (GO:0050794)	0.5	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
single-organism cellular process (GO:0044763)	0.65	7	IDH1, BRCA2, IDH2, TP53, ERBB2, PTEN, PPARG
biological regulation (GO:0065007)	0.39	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of biological process (GO:0050789)	0.45	7	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
single-organism process (GO:0044699)	0.48	7	IDH1, BRCA2, IDH2, TP53, ERBB2, PTEN, PPARG
positive regulation of metabolic process (GO:0009893)	1.74	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of cellular metabolic process (GO:0031325)	1.81	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cellular biosynthetic process (GO:0044249)	1.37	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cellular nitrogen compound metabolic process (GO:0034641)	1.22	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
nitrogen compound metabolic process (GO:0006807)	1.13	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
organic cyclic compound metabolic process (GO:1901360)	1.26	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cellular macromolecule metabolic process (GO:0044260)	0.93	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of macromolecule metabolic process (GO:0060255)	1.08	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of biological process (GO:0048518)	1.2	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of biological process (GO:0048519)	1.33	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
developmental process (GO:0032502)	1.36	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
organic substance biosynthetic process (GO:1901576)	1.34	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
single-organism developmental process (GO:0044767)	1.49	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
biosynthetic process (GO:0009058)	1.32	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
response to chemical (GO:0042221)	1.98	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
heterocycle metabolic process (GO:0046483)	1.31	6	IDH1, BRCA2, POT1, TP53, ERBB2, PPARG
response to stimulus (GO:0050896)	1.22	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
anatomical structure development (GO:0048856)	1.58	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
response to stress (GO:0006950)	1.8	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
macromolecule metabolic process (GO:0043170)	0.83	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of cellular process (GO:0048523)	1.41	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of cellular process (GO:0048522)	1.3	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of metabolic process (GO:0009892)	1.93	5	PPARG, POT1, BRCA2, TP53, PTEN
positive regulation of biosynthetic process (GO:0009891)	2.29	5	BRCA2, ERBB2, PPARG, POT1, TP53
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	5	BRCA2, ERBB2, PPARG, POT1, TP53
regulation of cellular component organization (GO:0051128)	2.01	5	PPARG, ERBB2, POT1, TP53, PTEN
nucleic acid metabolic process (GO:0090304)	1.46	5	BRCA2, ERBB2, PPARG, POT1, TP53
signal transduction (GO:0007165)	1.28	5	PPARG, ERBB2, BRCA2, TP53, PTEN
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	BRCA2, ERBB2, PPARG, POT1, TP53
organic cyclic compound biosynthetic process (GO:1901362)	1.66	5	BRCA2, ERBB2, PPARG, POT1, TP53
cellular component organization or biogenesis (GO:0071840)	1.22	5	POT1, ERBB2, BRCA2, TP53, PTEN
cellular response to stimulus (GO:0051716)	1.97	5	PPARG, ERBB2, BRCA2, TP53, PTEN
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	5	BRCA2, PTEN, PPARG, POT1, TP53
cellular developmental process (GO:0048869)	1.82	5	PPARG, ERBB2, BRCA2, TP53, PTEN
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	BRCA2, ERBB2, PPARG, POT1, TP53
cellular component organization (GO:0016043)	1.24	5	POT1, ERBB2, BRCA2, TP53, PTEN
animal organ development (GO:0048513)	2.53	5	BRCA2, ERBB2, PPARG, IDH1, PTEN
regulation of molecular function (GO:0065009)	1.78	5	PPARG, ERBB2, POT1, TP53, PTEN
regulation of biological quality (GO:0065008)	1.68	5	BRCA2, PTEN, PPARG, POT1, TP53
regulation of gene expression (GO:0010468)	1.37	5	PPARG, ERBB2, BRCA2, TP53, PTEN
heterocycle biosynthetic process (GO:0018130)	1.7	5	BRCA2, ERBB2, PPARG, POT1, TP53
regulation of cell proliferation (GO:0042127)	2.41	5	BRCA2, ERBB2, PPARG, PTEN, TP53
negative regulation of cell proliferation (GO:0008285)	3.26	5	PPARG, ERBB2, BRCA2, TP53, PTEN
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	BRCA2, PTEN, PPARG, POT1, TP53
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	5	BRCA2, ERBB2, PPARG, POT1, TP53
regulation of catalytic activity (GO:0050790)	1.97	5	PPARG, ERBB2, POT1, TP53, PTEN
single-organism metabolic process (GO:0044710)	1.63	5	ERBB2, PTEN, PPARG, IDH1, IDH2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	BRCA2, ERBB2, PPARG, PTEN, TP53
macromolecule biosynthetic process (GO:0009059)	1.61	5	BRCA2, ERBB2, PPARG, POT1, TP53
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	BRCA2, ERBB2, PPARG, PTEN, TP53
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	5	BRCA2, ERBB2, PPARG, POT1, TP53
response to organic substance (GO:0010033)	2.2	5	BRCA2, ERBB2, PPARG, IDH1, PTEN
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	5	BRCA2, ERBB2, PPARG, POT1, TP53
protein metabolic process (GO:0019538)	1.45	5	BRCA2, ERBB2, PPARG, PTEN, TP53
regulation of RNA metabolic process (GO:0051252)	1.52	5	BRCA2, ERBB2, PPARG, PTEN, TP53
regulation of transferase activity (GO:0051338)	2.88	5	ERBB2, PTEN, PPARG, POT1, TP53
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	PPARG, ERBB2, BRCA2, TP53, PTEN
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	BRCA2, ERBB2, PPARG, POT1, TP53
aromatic compound biosynthetic process (GO:0019438)	1.7	5	BRCA2, ERBB2, PPARG, POT1, TP53
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	BRCA2, ERBB2, PPARG, TP53
response to extracellular stimulus (GO:0009991)	3.71	4	BRCA2, PPARG, PTEN, TP53
negative regulation of multicellular organismal process (GO:0051241)	2.84	4	BRCA2, ERBB2, PPARG, PTEN
regulation of phosphate metabolic process (GO:0019220)	2.35	4	TP53, ERBB2, IDH1, PTEN
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	4	BRCA2, PPARG, POT1, TP53
negative regulation of biosynthetic process (GO:0009890)	2.47	4	BRCA2, PPARG, POT1, TP53
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	4	BRCA2, PPARG, POT1, TP53
regulation of transport (GO:0051049)	2.24	4	ERBB2, PPARG, TP53, PTEN
regulation of response to stimulus (GO:0048583)	1.54	4	ERBB2, PPARG, PTEN, TP53
positive regulation of protein metabolic process (GO:0051247)	2.43	4	ERBB2, PPARG, PTEN, TP53
positive regulation of gene expression (GO:0010628)	2.35	4	BRCA2, ERBB2, PPARG, TP53
small molecule metabolic process (GO:0044281)	2.38	4	IDH1, PPARG, IDH2, PTEN
cellular response to chemical stimulus (GO:0070887)	2.57	4	ERBB2, PPARG, PTEN, TP53
regulation of signaling (GO:0023051)	1.72	4	ERBB2, PPARG, TP53, PTEN
intracellular signal transduction (GO:0035556)	2.39	4	ERBB2, BRCA2, TP53, PTEN
regulation of cell communication (GO:0010646)	1.73	4	ERBB2, PPARG, PTEN, TP53
negative regulation of catalytic activity (GO:0043086)	3.0	4	PTEN, PPARG, POT1, TP53
response to organic cyclic compound (GO:0014070)	3.07	4	BRCA2, IDH1, PPARG, PTEN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	4	BRCA2, PPARG, POT1, TP53
cellular protein metabolic process (GO:0044267)	1.63	4	ERBB2, BRCA2, TP53, PTEN
protein modification process (GO:0036211)	1.79	4	ERBB2, BRCA2, TP53, PTEN
regulation of signal transduction (GO:0009966)	1.84	4	ERBB2, PPARG, PTEN, TP53
response to lipid (GO:0033993)	3.11	4	PPARG, IDH1, BRCA2, PTEN
regulation of growth (GO:0040008)	3.26	4	ERBB2, PPARG, PTEN, TP53
negative regulation of transferase activity (GO:0051348)	3.87	4	PTEN, PPARG, POT1, TP53
regulation of protein metabolic process (GO:0051246)	1.93	4	ERBB2, PPARG, TP53, PTEN
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	4	BRCA2, PPARG, POT1, TP53
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	ERBB2, PPARG, TP53, PTEN
positive regulation of catalytic activity (GO:0043085)	2.4	4	ERBB2, PPARG, POT1, PTEN
positive regulation of molecular function (GO:0044093)	2.23	4	ERBB2, PPARG, PTEN, POT1
negative regulation of molecular function (GO:0044092)	2.74	4	PPARG, POT1, TP53, PTEN
positive regulation of cellular component organization (GO:0051130)	2.68	4	ERBB2, PPARG, POT1, TP53
organelle organization (GO:0006996)	2.02	4	POT1, BRCA2, TP53, PTEN
negative regulation of DNA metabolic process (GO:0051053)	4.98	4	BRCA2, PPARG, POT1, TP53
regulation of DNA metabolic process (GO:0051052)	3.87	4	BRCA2, PPARG, POT1, TP53
cell proliferation (GO:0008283)	3.23	4	ERBB2, BRCA2, TP53, PTEN
regulation of developmental process (GO:0050793)	2.1	4	BRCA2, ERBB2, PPARG, PTEN
cellular protein modification process (GO:0006464)	1.79	4	ERBB2, BRCA2, TP53, PTEN
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	TP53, ERBB2, IDH1, PTEN
reproductive process (GO:0022414)	2.55	4	BRCA2, IDH1, PPARG, PTEN
macromolecule modification (GO:0043412)	1.73	4	ERBB2, BRCA2, TP53, PTEN
single organism reproductive process (GO:0044702)	2.73	4	PPARG, IDH1, BRCA2, PTEN
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	BRCA2, ERBB2, PPARG, TP53
regulation of multicellular organismal process (GO:0051239)	1.87	4	PPARG, ERBB2, BRCA2, PTEN
regulation of localization (GO:0032879)	1.94	4	ERBB2, PPARG, TP53, PTEN
localization (GO:0051179)	1.4	4	BRCA2, PPARG, POT1, TP53
regulation of hydrolase activity (GO:0051336)	2.53	4	ERBB2, PPARG, POT1, TP53
response to abiotic stimulus (GO:0009628)	2.8	4	BRCA2, PPARG, PTEN, TP53
regulation of cellular protein metabolic process (GO:0032268)	1.99	4	ERBB2, PPARG, PTEN, TP53
response to external stimulus (GO:0009605)	2.55	4	BRCA2, PPARG, PTEN, TP53
developmental process involved in reproduction (GO:0003006)	3.36	4	BRCA2, IDH1, PPARG, PTEN
response to nutrient levels (GO:0031667)	3.77	4	BRCA2, PPARG, PTEN, TP53
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	4	BRCA2, ERBB2, PPARG, TP53
positive regulation of RNA metabolic process (GO:0051254)	2.51	4	BRCA2, ERBB2, PPARG, TP53
regulation of multicellular organismal development (GO:2000026)	2.31	4	PPARG, ERBB2, BRCA2, PTEN
cellular response to stress (GO:0033554)	2.51	4	PPARG, BRCA2, TP53, PTEN
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	4	BRCA2, PPARG, POT1, TP53
cellular component assembly (GO:0022607)	2.14	3	POT1, TP53, PTEN
negative regulation of growth (GO:0045926)	4.24	3	PPARG, TP53, PTEN
RNA biosynthetic process (GO:0032774)	1.84	3	ERBB2, PPARG, TP53
regulation of cellular localization (GO:0060341)	3.03	3	ERBB2, TP53, PTEN
positive regulation of response to stimulus (GO:0048584)	2.18	3	ERBB2, TP53, PTEN
carboxylic acid metabolic process (GO:0019752)	3.12	3	IDH1, PPARG, IDH2
homeostatic process (GO:0042592)	2.61	3	BRCA2, PPARG, POT1
oxoacid metabolic process (GO:0043436)	3.12	3	IDH1, PPARG, IDH2
multicellular organismal process (GO:0032501)	1.45	3	BRCA2, TP53, PTEN
regulation of intracellular signal transduction (GO:1902531)	2.31	3	ERBB2, TP53, PTEN
positive regulation of intracellular signal transduction (GO:1902533)	2.95	3	ERBB2, TP53, PTEN
positive regulation of cell death (GO:0010942)	3.32	3	PPARG, PTEN, TP53
positive regulation of cell communication (GO:0010647)	2.41	3	ERBB2, TP53, PTEN
regulation of cell death (GO:0010941)	2.43	3	PPARG, TP53, PTEN
regulation of apoptotic process (GO:0042981)	2.5	3	PPARG, TP53, PTEN
carbohydrate metabolic process (GO:0005975)	3.26	3	IDH1, PTEN, IDH2
nucleic acid-templated transcription (GO:0097659)	1.91	3	ERBB2, PPARG, TP53
response to endogenous stimulus (GO:0009719)	2.79	3	IDH1, PPARG, PTEN
regulation of mitotic cell cycle (GO:0007346)	3.71	3	BRCA2, TP53, PTEN
organophosphate metabolic process (GO:0019637)	3.04	3	ERBB2, IDH1, PTEN
positive regulation of transferase activity (GO:0051347)	3.31	3	ERBB2, POT1, PTEN
positive regulation of hydrolase activity (GO:0051345)	2.91	3	ERBB2, PPARG, POT1
positive regulation of signal transduction (GO:0009967)	2.5	3	ERBB2, TP53, PTEN
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	ERBB2, TP53, PTEN
regulation of cell cycle process (GO:0010564)	3.5	3	BRCA2, TP53, PTEN
regulation of programmed cell death (GO:0043067)	2.49	3	PPARG, TP53, PTEN
peptidyl-amino acid modification (GO:0018193)	2.98	3	ERBB2, BRCA2, TP53
positive regulation of apoptotic process (GO:0043065)	3.38	3	PPARG, TP53, PTEN
rhythmic process (GO:0048511)	4.02	3	PPARG, TP53, PTEN
cellular response to oxygen levels (GO:0071453)	4.97	3	PPARG, TP53, PTEN
regulation of immune system process (GO:0002682)	2.5	3	ERBB2, PPARG, PTEN
organic acid metabolic process (GO:0006082)	3.01	3	IDH1, PPARG, IDH2
regulation of protein modification process (GO:0031399)	2.32	3	ERBB2, TP53, PTEN
negative regulation of telomerase activity (GO:0051974)	7.02	3	PPARG, POT1, TP53
aging (GO:0007568)	4.16	3	BRCA2, TP53, PTEN
response to oxygen levels (GO:0070482)	4.02	3	PPARG, PTEN, TP53
positive regulation of programmed cell death (GO:0043068)	3.38	3	PPARG, TP53, PTEN
regulation of telomerase activity (GO:0051972)	5.97	3	PPARG, POT1, TP53
positive regulation of signaling (GO:0023056)	2.41	3	ERBB2, TP53, PTEN
RNA metabolic process (GO:0016070)	1.59	3	ERBB2, PPARG, TP53
cell communication (GO:0007154)	3.04	3	PPARG, PTEN, TP53
cell differentiation (GO:0030154)	2.14	3	ERBB2, PPARG, TP53
reproductive structure development (GO:0048608)	4.08	3	BRCA2, IDH1, PPARG
lipid metabolic process (GO:0006629)	2.68	3	ERBB2, PPARG, PTEN
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	ERBB2, TP53, PTEN
positive regulation of transport (GO:0051050)	2.9	3	ERBB2, PPARG, TP53
response to nutrient (GO:0007584)	4.49	3	PPARG, BRCA2, PTEN
regulation of DNA biosynthetic process (GO:2000278)	5.17	3	PPARG, POT1, TP53
monocarboxylic acid metabolic process (GO:0032787)	3.57	3	IDH1, PPARG, IDH2
establishment of protein localization (GO:0045184)	2.53	3	BRCA2, PPARG, POT1
DNA metabolic process (GO:0006259)	3.09	3	BRCA2, POT1, TP53
regulation of cell differentiation (GO:0045595)	2.42	3	ERBB2, PPARG, PTEN
regulation of cell growth (GO:0001558)	3.75	3	ERBB2, PPARG, TP53
response to oxygen-containing compound (GO:1901700)	2.57	3	PPARG, BRCA2, PTEN
single-organism carbohydrate metabolic process (GO:0044723)	3.42	3	IDH1, PTEN, IDH2
cellular carbohydrate metabolic process (GO:0044262)	4.74	3	IDH1, PTEN, IDH2
cellular lipid metabolic process (GO:0044255)	2.92	3	ERBB2, PPARG, PTEN
establishment of localization (GO:0051234)	1.48	3	BRCA2, PPARG, POT1
lipid modification (GO:0030258)	4.37	3	ERBB2, PPARG, PTEN
oxidation-reduction process (GO:0055114)	2.91	3	IDH1, PPARG, IDH2
developmental maturation (GO:0021700)	4.7	3	PPARG, BRCA2, PTEN
regulation of phosphorylation (GO:0042325)	2.5	3	ERBB2, TP53, PTEN
heart development (GO:0007507)	4.24	3	ERBB2, PPARG, PTEN
positive regulation of phosphorylation (GO:0042327)	2.9	3	ERBB2, TP53, PTEN
regulation of epithelial cell proliferation (GO:0050678)	4.06	3	ERBB2, BRCA2, PTEN
negative regulation of developmental process (GO:0051093)	3.17	3	ERBB2, BRCA2, PTEN
single-multicellular organism process (GO:0044707)	1.78	3	BRCA2, TP53, PTEN
regulation of cell cycle (GO:0051726)	2.93	3	BRCA2, TP53, PTEN
positive regulation of protein modification process (GO:0031401)	2.7	3	ERBB2, TP53, PTEN
response to drug (GO:0042493)	3.71	3	PPARG, TP53, PTEN
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	ERBB2, IDH1, PTEN
transcription, DNA-templated (GO:0006351)	1.91	3	ERBB2, PPARG, TP53
phosphorus metabolic process (GO:0006793)	2.15	3	ERBB2, IDH1, PTEN
negative regulation of DNA biosynthetic process (GO:2000279)	6.23	3	PPARG, POT1, TP53
regulation of protein phosphorylation (GO:0001932)	2.57	3	ERBB2, TP53, PTEN
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	ERBB2, TP53, PTEN
negative regulation of cell differentiation (GO:0045596)	3.33	3	ERBB2, PPARG, PTEN
regulation of intracellular protein transport (GO:0033157)	3.8	2	ERBB2, TP53
regulation of kinase activity (GO:0043549)	3.07	2	ERBB2, PTEN
positive regulation of intracellular transport (GO:0032388)	4.08	2	ERBB2, TP53
developmental growth (GO:0048589)	4.05	2	BRCA2, PTEN
anatomical structure homeostasis (GO:0060249)	4.25	2	BRCA2, POT1
regulation of intracellular transport (GO:0032386)	3.58	2	ERBB2, TP53
cell maturation (GO:0048469)	4.98	2	BRCA2, PPARG
behavior (GO:0007610)	3.47	2	TP53, PTEN
membrane organization (GO:0061024)	3.04	2	TP53, PTEN
negative regulation of cell adhesion (GO:0007162)	4.33	2	ERBB2, PTEN
cell surface receptor signaling pathway (GO:0007166)	2.09	2	ERBB2, PTEN
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	ERBB2, PTEN
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	2	ERBB2, PTEN
tricarboxylic acid metabolic process (GO:0072350)	7.09	2	IDH1, IDH2
negative regulation of cell cycle (GO:0045786)	3.67	2	TP53, PTEN
positive regulation of cell cycle (GO:0045787)	3.94	2	BRCA2, TP53
negative regulation of signal transduction (GO:0009968)	2.75	2	PPARG, PTEN
regulation of organelle organization (GO:0033043)	2.72	2	POT1, TP53
circadian behavior (GO:0048512)	6.84	2	TP53, PTEN
macromolecule localization (GO:0033036)	2.34	2	PPARG, TP53
negative regulation of response to stimulus (GO:0048585)	2.52	2	PPARG, PTEN
negative regulation of immune system process (GO:0002683)	3.85	2	ERBB2, PPARG
regulation of lymphocyte apoptotic process (GO:0070228)	5.7	2	TP53, PTEN
DNA repair (GO:0006281)	3.59	2	BRCA2, TP53
negative regulation of cell death (GO:0060548)	2.95	2	TP53, PTEN
regulation of protein kinase activity (GO:0045859)	3.15	2	ERBB2, PTEN
nucleotide-excision repair (GO:0006289)	5.05	2	BRCA2, TP53
regulation of circadian rhythm (GO:0042752)	5.09	2	PPARG, TP53
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	PPARG, PTEN
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	ERBB2, PTEN
female gonad development (GO:0008585)	6.64	2	IDH1, BRCA2
glycerolipid metabolic process (GO:0046486)	3.91	2	ERBB2, PTEN
glyoxylate metabolic process (GO:0046487)	6.4	2	IDH1, IDH2
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	2	BRCA2, TP53
dicarboxylic acid metabolic process (GO:0043648)	5.3	2	IDH1, IDH2
cellular response to extracellular stimulus (GO:0031668)	4.57	2	PPARG, TP53
cellular response to nutrient levels (GO:0031669)	4.7	2	PPARG, TP53
peptidyl-lysine modification (GO:0018205)	3.98	2	BRCA2, TP53
response to organonitrogen compound (GO:0010243)	3.2	2	PPARG, PTEN
positive regulation of organelle organization (GO:0010638)	3.38	2	POT1, TP53
immune system process (GO:0002376)	2.29	2	PPARG, PTEN
response to light stimulus (GO:0009416)	4.08	2	BRCA2, TP53
negative regulation of epithelial cell proliferation (GO:0050680)	4.98	2	BRCA2, PTEN
negative regulation of cell communication (GO:0010648)	2.66	2	PPARG, PTEN
regulation of catabolic process (GO:0009894)	3.52	2	IDH1, PTEN
positive regulation of apoptotic signaling pathway (GO:2001235)	4.58	2	TP53, PTEN
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	ERBB2, PTEN
movement of cell or subcellular component (GO:0006928)	2.61	2	ERBB2, PTEN
negative regulation of gene expression (GO:0010629)	2.48	2	PPARG, TP53
positive regulation of protein transport (GO:0051222)	3.61	2	ERBB2, TP53
regulation of protein transport (GO:0051223)	3.12	2	ERBB2, TP53
signal transduction by p53 class mediator (GO:0072331)	4.88	2	BRCA2, TP53
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	5.76	2	BRCA2, TP53
organic substance catabolic process (GO:1901575)	2.45	2	TP53, PTEN
positive regulation of establishment of protein localization (GO:1904951)	3.49	2	ERBB2, TP53
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	PPARG, TP53
regulation of lipid metabolic process (GO:0019216)	4.08	2	IDH1, PPARG
gonad development (GO:0008406)	4.92	2	IDH1, BRCA2
positive regulation of cellular protein localization (GO:1903829)	3.85	2	ERBB2, TP53
cellular response to hypoxia (GO:0071456)	5.11	2	TP53, PTEN
regulation of MAPK cascade (GO:0043408)	3.22	2	ERBB2, PTEN
regulation of establishment of protein localization (GO:0070201)	3.02	2	ERBB2, TP53
establishment of protein localization to telomere (GO:0070200)	7.94	2	BRCA2, POT1
circadian rhythm (GO:0007623)	4.79	2	TP53, PTEN
rhythmic behavior (GO:0007622)	6.78	2	TP53, PTEN
response to X-ray (GO:0010165)	6.33	2	BRCA2, TP53
positive regulation of MAPK cascade (GO:0043410)	3.57	2	ERBB2, PTEN
programmed cell death (GO:0012501)	3.1	2	TP53, PTEN
single-organism membrane organization (GO:0044802)	3.19	2	TP53, PTEN
cell aging (GO:0007569)	5.54	2	BRCA2, TP53
negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)	5.17	2	TP53, PTEN
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	2	ERBB2, PTEN
inositol lipid-mediated signaling (GO:0048017)	4.91	2	ERBB2, PTEN
regulation of cell cycle phase transition (GO:1901987)	4.15	2	TP53, PTEN
response to decreased oxygen levels (GO:0036293)	4.09	2	TP53, PTEN
regulation of response to stress (GO:0080134)	2.53	2	PPARG, PTEN
establishment of protein localization to chromosome (GO:0070199)	7.16	2	BRCA2, POT1
regulation of nervous system development (GO:0051960)	3.1	2	PPARG, PTEN
regulation of cell motility (GO:2000145)	3.16	2	ERBB2, PTEN
2-oxoglutarate metabolic process (GO:0006103)	6.78	2	IDH1, IDH2
isocitrate metabolic process (GO:0006102)	8.12	2	IDH1, IDH2
positive regulation of chromosome organization (GO:2001252)	4.76	2	POT1, TP53
regulation of chromosome organization (GO:0033044)	4.11	2	POT1, TP53
synapse organization (GO:0050808)	4.87	2	ERBB2, PTEN
negative regulation of response to external stimulus (GO:0032102)	4.18	2	PPARG, PTEN
negative regulation of cell growth (GO:0030308)	4.58	2	PPARG, TP53
regulation of response to external stimulus (GO:0032101)	3.06	2	PPARG, PTEN
negative regulation of fibroblast proliferation (GO:0048147)	6.4	2	PPARG, TP53
response to radiation (GO:0009314)	3.69	2	BRCA2, TP53
regulation of fibroblast proliferation (GO:0048145)	5.32	2	PPARG, TP53
DNA damage response, signal transduction resulting in transcription (GO:0042772)	7.02	2	BRCA2, TP53
regulation of cellular protein localization (GO:1903827)	3.43	2	ERBB2, TP53
negative regulation of signaling (GO:0023057)	2.65	2	PPARG, PTEN
response to UV (GO:0009411)	4.88	2	BRCA2, TP53
negative regulation of mitotic cell cycle phase transition (GO:1901991)	4.82	2	TP53, PTEN
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	2	TP53, PTEN
response to purine-containing compound (GO:0014074)	4.67	2	PPARG, PTEN
response to hypoxia (GO:0001666)	4.13	2	TP53, PTEN
cell cycle (GO:0007049)	3.14	2	BRCA2, TP53
regulation of protein localization (GO:0032880)	2.88	2	ERBB2, TP53
telomere maintenance (GO:0000723)	5.37	2	BRCA2, POT1
regulation of neurogenesis (GO:0050767)	3.21	2	PPARG, PTEN
regulation of phagocytosis (GO:0050764)	5.49	2	PPARG, PTEN
response to ionizing radiation (GO:0010212)	4.74	2	BRCA2, TP53
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	PPARG, TP53
catabolic process (GO:0009056)	2.38	2	TP53, PTEN
response to nitrogen compound (GO:1901698)	3.12	2	PPARG, PTEN
regulation of cell development (GO:0060284)	3.01	2	PPARG, PTEN
negative regulation of cell cycle phase transition (GO:1901988)	4.74	2	TP53, PTEN
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	TP53, PTEN
positive regulation of cell proliferation (GO:0008284)	3.01	2	ERBB2, PTEN
phospholipid metabolic process (GO:0006644)	3.88	2	ERBB2, PTEN
cellular response to external stimulus (GO:0071496)	4.2	2	PPARG, TP53
multicellular organismal reproductive process (GO:0048609)	3.35	2	BRCA2, PTEN
establishment of protein localization to organelle (GO:0072594)	3.92	2	BRCA2, POT1
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	2	PPARG, TP53
cellular response to DNA damage stimulus (GO:0006974)	3.17	2	BRCA2, TP53
regulation of locomotion (GO:0040012)	3.12	2	ERBB2, PTEN
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	2	PPARG, TP53
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	2	ERBB2, PTEN
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	7.09	2	BRCA2, TP53
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	PPARG, PTEN
regulation of immune response (GO:0050776)	2.98	2	PPARG, PTEN
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	TP53, PTEN
regulation of helicase activity (GO:0051095)	7.53	2	POT1, TP53
response to hormone (GO:0009725)	3.33	2	IDH1, PPARG
negative regulation of RNA metabolic process (GO:0051253)	2.66	2	PPARG, TP53
negative regulation of cell cycle process (GO:0010948)	4.37	2	TP53, PTEN
positive regulation of proteolysis (GO:0045862)	3.86	2	PPARG, PTEN
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	2	PPARG, TP53
system development (GO:0048731)	2.92	2	ERBB2, PTEN
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	2	ERBB2, PTEN
DNA biosynthetic process (GO:0071897)	4.89	2	BRCA2, POT1
glycerophospholipid metabolic process (GO:0006650)	4.13	2	ERBB2, PTEN
regulation of cellular catabolic process (GO:0031329)	3.83	2	IDH1, PTEN
macromolecular complex subunit organization (GO:0043933)	2.14	2	BRCA2, TP53
apoptotic signaling pathway (GO:0097190)	4.12	2	BRCA2, TP53
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	2	BRCA2, TP53
tricarboxylic acid cycle (GO:0006099)	6.33	2	IDH1, IDH2
cell cycle process (GO:0022402)	2.75	2	BRCA2, TP53
cellular response to decreased oxygen levels (GO:0036294)	5.05	2	TP53, PTEN
response to starvation (GO:0042594)	4.69	2	PPARG, TP53
cell death (GO:0008219)	3.05	2	TP53, PTEN
glyoxylate cycle (GO:0006097)	9.04	2	IDH1, IDH2
multicellular organism development (GO:0007275)	2.54	2	BRCA2, TP53
response to estradiol (GO:0032355)	4.73	2	BRCA2, PTEN
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	ERBB2, PTEN
growth (GO:0040007)	3.8	2	BRCA2, PTEN
regulation of cellular component biogenesis (GO:0044087)	3.08	2	TP53, PTEN
chromatin organization (GO:0006325)	3.28	2	BRCA2, TP53
response to gamma radiation (GO:0010332)	5.78	2	BRCA2, TP53
cellular response to organic substance (GO:0071310)	2.78	2	ERBB2, PPARG
negative regulation of apoptotic process (GO:0043066)	3.04	2	TP53, PTEN
multi-organism process (GO:0051704)	2.65	2	TP53, PTEN
negative regulation of programmed cell death (GO:0043069)	3.02	2	TP53, PTEN
negative regulation of mitotic cell cycle (GO:0045930)	4.45	2	TP53, PTEN
DNA damage response, signal transduction by p53 class mediator (GO:0030330)	5.3	2	BRCA2, TP53
apoptotic process (GO:0006915)	3.14	2	TP53, PTEN
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	ERBB2, TP53
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	2	PPARG, TP53
regulation of cell adhesion (GO:0030155)	3.27	2	ERBB2, PTEN
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	PPARG, PTEN
regulation of endocytosis (GO:0030100)	4.42	2	PPARG, PTEN
signal transduction in response to DNA damage (GO:0042770)	5.15	2	BRCA2, TP53
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)	6.33	2	BRCA2, TP53
regulation of cellular component movement (GO:0051270)	3.08	2	ERBB2, PTEN
chromosome organization (GO:0051276)	3.79	2	BRCA2, POT1
nervous system development (GO:0007399)	3.53	2	ERBB2, PTEN
regulation of leukocyte apoptotic process (GO:2000106)	5.33	2	TP53, PTEN
telomere organization (GO:0032200)	5.33	2	BRCA2, POT1
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	TP53, PTEN
negative regulation of cell cycle G1/S phase transition (GO:1902807)	5.14	2	TP53, PTEN
regulation of proteolysis (GO:0030162)	3.2	2	PPARG, PTEN

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of intracellular protein transport (GO:0033157)	-	3.8	0.026	PPARG, ERBB2, POT1, TP53, PTEN
protein localization (GO:0008104)	NEW	2.36	0.019	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of intracellular transport (GO:0032388)	-	4.08	0.013	PPARG, ERBB2, POT1, TP53, PTEN
memory (GO:0007613)	NEW	5.13	0.022	PTEN, PPARG, POT1, TP53
female gonad development (GO:0008585)	-	6.64	0.003	IDH1, BRCA2, TP53
learning or memory (GO:0007611)	NEW	4.33	0.012	ERBB2, PTEN, PPARG, POT1, TP53
negative regulation of cell adhesion (GO:0007162)	-	4.33	0.001	ERBB2, PTEN, PPARG, POT1, TP53
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	NEW	5.13	0.015	ERBB2, PPARG, PTEN, TP53
face morphogenesis (GO:0060325)	NEW	6.29	0.021	ERBB2, TP53, PTEN
positive regulation of chemotaxis (GO:0050921)	NEW	4.94	0.019	PTEN, PPARG, POT1, TP53
multicellular organism growth (GO:0035264)	NEW	5.37	0.007	ERBB2, PPARG, POT1, TP53
response to alkaloid (GO:0043279)	NEW	4.83	0.03	BRCA2, PPARG, POT1, TP53
response to zinc ion (GO:0010043)	NEW	5.67	0.032	POT1, TP53, PTEN
hemostasis (GO:0007599)	NEW	4.5	0.016	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
tricarboxylic acid metabolic process (GO:0072350)	-	7.09	0.017	IDH1, IDH2
activation of protein kinase activity (GO:0032147)	NEW	4.08	0.019	PPARG, ERBB2, POT1, TP53, PTEN
signal transduction by phosphorylation (GO:0023014)	NEW	3.79	0.005	ERBB2, PTEN, PPARG, POT1, TP53
response to amino acid (GO:0043200)	NEW	5.12	0.01	ERBB2, PPARG, PTEN, TP53
single-organism metabolic process (GO:0044710)	-	1.63	0.027	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
negative regulation of cell cycle (GO:0045786)	-	3.67	0.022	PPARG, ERBB2, POT1, TP53, PTEN
positive regulation of cell cycle (GO:0045787)	-	3.94	0.001	PPARG, ERBB2, BRCA2, TP53, PTEN
taxis (GO:0042330)	NEW	4.03	0.023	ERBB2, PTEN, PPARG, POT1, TP53
MAPK cascade (GO:0000165)	NEW	3.91	0.002	PPARG, ERBB2, POT1, TP53, PTEN
hormone secretion (GO:0046879)	NEW	5.48	0.005	PPARG, POT1, TP53, PTEN
regulation of neuron differentiation (GO:0045664)	NEW	3.39	0.042	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of osteoblast differentiation (GO:0045667)	NEW	4.99	0.017	ERBB2, PPARG, TP53, PTEN
organ development (GO:0048513)	-	2.53	0.002	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
positive regulation of lipid metabolic process (GO:0045834)	NEW	4.88	0.013	ERBB2, PPARG, PTEN, TP53
nucleobase-containing small molecule metabolic process (GO:0055086)	NEW	3.59	0.037	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of cell development (GO:0010720)	NEW	3.57	0.038	ERBB2, PTEN, PPARG, POT1, TP53
regulation of phosphatase activity (GO:0010921)	NEW	4.88	0.023	ERBB2, POT1, TP53, PTEN
macromolecule localization (GO:0033036)	-	2.34	0.021	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of osteoblast differentiation (GO:0045668)	NEW	6.02	0.029	ERBB2, PPARG, TP53
epithelial cell development (GO:0002064)	NEW	4.92	0.023	PTEN, PPARG, POT1, TP53
cellular homeostasis (GO:0019725)	NEW	3.23	0.039	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of DNA metabolic process (GO:0051054)	NEW	4.49	0.001	ERBB2, PTEN, PPARG, POT1, TP53
negative regulation of DNA metabolic process (GO:0051053)	-	4.98	0.004	BRCA2, POT1, TP53
chemotaxis (GO:0006935)	NEW	4.04	0.023	ERBB2, PTEN, PPARG, POT1, TP53
histone H3 acetylation (GO:0043966)	NEW	5.92	0.024	BRCA2, POT1, TP53
histone H4 acetylation (GO:0043967)	NEW	5.82	0.021	BRCA2, POT1, TP53
response to corticosteroid (GO:0031960)	NEW	4.56	0.004	PPARG, ERBB2, POT1, TP53, PTEN
negative regulation of cellular protein metabolic process (GO:0032269)	NEW	2.88	0.042	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of small GTPase mediated signal transduction (GO:0051058)	NEW	6.04	0.026	ERBB2, TP53, PTEN
positive regulation of protein tyrosine kinase activity (GO:0061098)	NEW	6.07	0.022	ERBB2, POT1, TP53
regulation of blood vessel endothelial cell migration (GO:0043535)	NEW	5.8	0.044	PPARG, TP53, PTEN
response to cAMP (GO:0051591)	NEW	5.08	0.021	ERBB2, PPARG, POT1, TP53
regionalization (GO:0003002)	NEW	4.24	0.042	BRCA2, ERBB2, PPARG, PTEN, TP53
regulation of embryonic development (GO:0045995)	NEW	4.98	0.017	ERBB2, PPARG, TP53, PTEN
oxoacid metabolic process (GO:0043436)	-	3.12	0.03	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
glyoxylate metabolic process (GO:0046487)	-	6.4	0.005	IDH1, IDH2
oxidation-reduction process (GO:0055114)	-	2.91	0.031	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cell aging (GO:0007569)	-	5.54	0.001	ERBB2, BRCA2, TP53, PTEN
dicarboxylic acid metabolic process (GO:0043648)	-	5.3	0.002	IDH1, POT1, TP53, IDH2
cellular response to extracellular stimulus (GO:0031668)	-	4.57	0.001	ERBB2, PTEN, PPARG, POT1, TP53
cellular amide metabolic process (GO:0043603)	NEW	3.23	0.032	IDH1, PPARG, PTEN, POT1
multicellular organismal homeostasis (GO:0048871)	NEW	5.07	0.047	PPARG, POT1, TP53
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	NEW	4.62	0.002	ERBB2, PTEN, PPARG, POT1, TP53
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	NEW	4.35	0.006	ERBB2, PTEN, PPARG, POT1, TP53
fertilization (GO:0009566)	NEW	5.1	0.014	ERBB2, PPARG, POT1, TP53
regulation of DNA replication (GO:0006275)	NEW	5.02	0.0	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
long-term synaptic potentiation (GO:0060291)	NEW	6.07	0.015	PPARG, TP53, PTEN
response to UV (GO:0009411)	-	4.88	0.006	POT1, BRCA2, TP53, PTEN
SMAD protein signal transduction (GO:0060395)	NEW	5.65	0.001	PPARG, PTEN, TP53
muscle cell differentiation (GO:0042692)	NEW	5.09	0.035	ERBB2, PPARG, PTEN, TP53
negative regulation of epithelial cell proliferation (GO:0050680)	-	4.98	0.031	ERBB2, BRCA2, TP53, PTEN
chromatin modification (GO:0016568)	NEW	4.06	0.005	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
covalent chromatin modification (GO:0016569)	NEW	3.89	0.001	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
establishment or maintenance of bipolar cell polarity (GO:0061245)	NEW	6.15	0.008	ERBB2, TP53, PTEN
small molecule catabolic process (GO:0044282)	NEW	3.99	0.013	POT1, PTEN, PPARG, TP53, IDH2
regulation of glucose metabolic process (GO:0010906)	NEW	5.08	0.014	ERBB2, PPARG, PTEN, TP53
regulation of synaptic plasticity (GO:0048167)	NEW	4.78	0.001	PPARG, ERBB2, POT1, TP53, PTEN
single organism cell adhesion (GO:0098602)	NEW	3.63	0.04	ERBB2, PTEN, PPARG, POT1, TP53
nicotinamide nucleotide metabolic process (GO:0046496)	NEW	5.14	0.034	IDH1, POT1, TP53
regulation of microtubule-based process (GO:0032886)	NEW	4.79	0.014	ERBB2, POT1, TP53, PTEN
positive regulation of protein serine/threonine kinase activity (GO:0071902)	NEW	4.06	0.03	PPARG, ERBB2, POT1, TP53, PTEN
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.046	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
developmental maturation (GO:0021700)	-	4.7	0.006	PPARG, ERBB2, BRCA2, TP53, PTEN
insulin secretion (GO:0030073)	NEW	6.09	0.046	PPARG, POT1, TP53
protein acylation (GO:0043543)	NEW	4.65	0.031	POT1, BRCA2, TP53, PTEN
establishment or maintenance of apical/basal cell polarity (GO:0035088)	NEW	6.15	0.008	ERBB2, TP53, PTEN
regulation of DNA-dependent DNA replication (GO:0090329)	NEW	5.97	0.009	BRCA2, PPARG, TP53
cellular carbohydrate metabolic process (GO:0044262)	-	4.74	0.048	IDH2, IDH1, PPARG, POT1, PTEN
cell morphogenesis (GO:0000902)	NEW	4.35	0.013	ERBB2, PTEN, PPARG, POT1, TP53
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100)	NEW	5.12	0.003	ERBB2, PPARG, PTEN, TP53
negative regulation of transferase activity (GO:0051348)	-	3.87	0.028	PPARG, ERBB2, POT1, TP53, PTEN
gonad development (GO:0008406)	-	4.92	0.001	BRCA2, IDH1, PPARG, PTEN, TP53
inflammatory response to antigenic stimulus (GO:0002437)	NEW	6.51	0.005	ERBB2, POT1, TP53
regulation of anatomical structure size (GO:0090066)	NEW	3.78	0.014	ERBB2, PTEN, PPARG, POT1, TP53
regulation of leukocyte migration (GO:0002685)	NEW	4.72	0.033	PPARG, POT1, TP53, PTEN
histone modification (GO:0016570)	NEW	3.91	0.0	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of cytokine-mediated signaling pathway (GO:0001960)	NEW	6.07	0.019	PPARG, TP53, PTEN
regulation of protein tyrosine kinase activity (GO:0061097)	NEW	5.59	0.001	ERBB2, POT1, TP53, PTEN
negative regulation of telomerase activity (GO:0051974)	-	7.02	0.005	PPARG, POT1
cellular response to abiotic stimulus (GO:0071214)	NEW	4.15	0.025	ERBB2, PTEN, PPARG, POT1, TP53
regulation of telomerase activity (GO:0051972)	-	5.97	0.012	PPARG, POT1
organ morphogenesis (GO:0009887)	NEW	3.55	0.027	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of DNA biosynthetic process (GO:2000278)	-	5.17	0.019	PPARG, POT1, TP53
amine metabolic process (GO:0009308)	NEW	5.74	0.04	ERBB2, PPARG, POT1, TP53
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.041	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of cell motility (GO:2000146)	NEW	4.36	0.007	PPARG, ERBB2, POT1, TP53, PTEN
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.042	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of DNA replication (GO:0008156)	NEW	6.17	0.0	BRCA2, POT1, TP53
exocytosis (GO:0006887)	NEW	4.11	0.015	ERBB2, PTEN, PPARG, POT1, TP53
single-organism carbohydrate metabolic process (GO:0044723)	-	3.42	0.001	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
regulation of carbohydrate biosynthetic process (GO:0043255)	NEW	5.25	0.0	ERBB2, PTEN, PPARG, POT1, TP53
leukocyte differentiation (GO:0002521)	NEW	4.13	0.032	ERBB2, PTEN, PPARG, POT1, TP53
Fc receptor signaling pathway (GO:0038093)	NEW	4.45	0.009	ERBB2, PTEN, PPARG, POT1, TP53
response to decreased oxygen levels (GO:0036293)	-	4.09	0.038	ERBB2, PTEN, PPARG, POT1, TP53
negative regulation of protein modification process (GO:0031400)	NEW	3.4	0.008	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of protein stability (GO:0031647)	NEW	4.33	0.036	ERBB2, PPARG, TP53, PTEN
cognition (GO:0050890)	NEW	4.2	0.024	PPARG, ERBB2, POT1, TP53, PTEN
positive regulation of leukocyte activation (GO:0002696)	NEW	4.0	0.001	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
lung cell differentiation (GO:0060479)	NEW	6.47	0.013	ERBB2, PPARG, TP53
2-oxoglutarate metabolic process (GO:0006103)	-	6.78	0.022	IDH1, IDH2
isocitrate metabolic process (GO:0006102)	-	8.12	0.012	IDH1, IDH2
nucleoside phosphate metabolic process (GO:0006753)	NEW	3.71	0.026	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of immune effector process (GO:0002699)	NEW	4.69	0.002	PPARG, ERBB2, POT1, TP53, PTEN
cellular biogenic amine metabolic process (GO:0006576)	NEW	5.92	0.024	ERBB2, PPARG, POT1, TP53
synapse organization (GO:0050808)	-	4.87	0.001	PPARG, ERBB2, POT1, TP53, PTEN
negative regulation of response to external stimulus (GO:0032102)	-	4.18	0.049	PPARG, TP53, PTEN
positive regulation of response to external stimulus (GO:0032103)	NEW	4.17	0.013	ERBB2, PTEN, PPARG, POT1, TP53
negative regulation of cell growth (GO:0030308)	-	4.58	0.004	PPARG, ERBB2, POT1, TP53, PTEN
response to radiation (GO:0009314)	-	3.69	0.021	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of phosphatase activity (GO:0010923)	NEW	5.48	0.001	ERBB2, POT1, TP53, PTEN
regulation of cytokine-mediated signaling pathway (GO:0001959)	NEW	4.82	0.011	PTEN, PPARG, POT1, TP53
regulation of synaptic transmission (GO:0050804)	NEW	4.09	0.027	ERBB2, PTEN, PPARG, POT1, TP53
regulation of T cell differentiation (GO:0045580)	NEW	5.07	0.021	ERBB2, PPARG, TP53, PTEN
negative regulation of response to cytokine stimulus (GO:0060761)	NEW	5.97	0.029	PPARG, TP53, PTEN
embryo development ending in birth or egg hatching (GO:0009792)	NEW	4.35	0.018	ERBB2, PTEN, PPARG, POT1, TP53
response to light stimulus (GO:0009416)	-	4.08	0.004	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of response to cytokine stimulus (GO:0060759)	NEW	4.77	0.017	PTEN, PPARG, POT1, TP53
negative regulation of signal transduction in absence of ligand (GO:1901099)	NEW	6.2	0.023	ERBB2, TP53, PTEN
negative regulation of growth (GO:0045926)	-	4.24	0.03	ERBB2, PTEN, PPARG, POT1, TP53
response to hypoxia (GO:0001666)	-	4.13	0.036	ERBB2, PTEN, PPARG, POT1, TP53
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.031	ERBB2, POT1, TP53, PTEN
synapse assembly (GO:0007416)	NEW	5.55	0.001	ERBB2, PPARG, TP53, PTEN
central nervous system development (GO:0007417)	NEW	4.84	0.003	PPARG, ERBB2, POT1, TP53, PTEN
in utero embryonic development (GO:0001701)	NEW	4.4	0.014	PPARG, ERBB2, POT1, TP53, PTEN
response to ionizing radiation (GO:0010212)	-	4.74	0.014	PPARG, BRCA2, TP53, PTEN
rhythmic process (GO:0048511)	-	4.02	0.028	PPARG, ERBB2, BRCA2, TP53, PTEN
phototransduction (GO:0007602)	NEW	5.99	0.04	PPARG, POT1, TP53, PTEN
nuclear division (GO:0000280)	NEW	3.85	0.047	POT1, ERBB2, BRCA2, TP53, PTEN
stress-activated protein kinase signaling cascade (GO:0031098)	NEW	5.41	0.003	ERBB2, POT1, TP53, PTEN
negative regulation of neurogenesis (GO:0050768)	NEW	4.22	0.042	ERBB2, PPARG, TP53, PTEN
positive regulation of neurogenesis (GO:0050769)	NEW	3.77	0.005	ERBB2, PTEN, PPARG, POT1, TP53
positive regulation of DNA replication (GO:0045740)	NEW	5.8	0.001	ERBB2, POT1, TP53, PTEN
central nervous system neuron axonogenesis (GO:0021955)	NEW	6.51	0.013	PPARG, PTEN, TP53
chordate embryonic development (GO:0043009)	NEW	4.38	0.015	PPARG, ERBB2, POT1, TP53, PTEN
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)	NEW	6.2	0.023	ERBB2, TP53, PTEN
negative regulation of cell proliferation (GO:0008285)	-	3.26	0.002	PPARG, ERBB2, BRCA2, TP53, PTEN
cellular response to external stimulus (GO:0071496)	-	4.2	0.011	ERBB2, PTEN, PPARG, POT1, TP53
reproductive structure development (GO:0048608)	-	4.08	0.0	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
negative regulation of locomotion (GO:0040013)	NEW	4.22	0.018	ERBB2, PTEN, PPARG, POT1, TP53
positive regulation of T cell activation (GO:0050870)	NEW	4.39	0.006	ERBB2, PTEN, PPARG, POT1, TP53
B cell activation (GO:0042113)	NEW	4.84	0.042	ERBB2, PPARG, TP53, PTEN
cellular amine metabolic process (GO:0044106)	NEW	5.92	0.024	ERBB2, PPARG, POT1, TP53
defense response to other organism (GO:0098542)	NEW	3.75	0.045	ERBB2, PTEN, PPARG, POT1, TP53
T cell activation (GO:0042110)	NEW	4.45	0.012	PPARG, POT1, BRCA2, TP53, PTEN
response to cold (GO:0009409)	NEW	5.9	0.0	ERBB2, PPARG, PTEN, TP53
positive regulation of lipid biosynthetic process (GO:0046889)	NEW	5.55	0.001	ERBB2, PPARG, PTEN, TP53
cellular lipid metabolic process (GO:0044255)	-	2.92	0.015	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (GO:0006978)	-	7.09	0.017	BRCA2, TP53
response to oxidative stress (GO:0006979)	NEW	3.9	0.001	IDH1, POT1, TP53, ERBB2, PTEN, PPARG
placenta development (GO:0001890)	NEW	5.99	0.017	PPARG, POT1, TP53
cell projection morphogenesis (GO:0048858)	NEW	4.05	0.021	PPARG, ERBB2, POT1, TP53, PTEN
protein oligomerization (GO:0051259)	NEW	3.71	0.006	IDH2, POT1, TP53, ERBB2, PTEN, PPARG
organic acid metabolic process (GO:0006082)	-	3.01	0.033	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	-	4.29	0.009	PPARG, ERBB2, POT1, TP53, PTEN
aging (GO:0007568)	-	4.16	0.012	BRCA2, PTEN, PPARG, POT1, TP53
cellular aldehyde metabolic process (GO:0006081)	NEW	5.74	0.011	IDH1, POT1, IDH2
regulation of dendrite development (GO:0050773)	NEW	4.93	0.0	ERBB2, PTEN, PPARG, POT1, TP53
positive regulation of lymphocyte activation (GO:0051251)	NEW	4.07	0.001	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of binding (GO:0051098)	NEW	4.08	0.017	PPARG, ERBB2, POT1, TP53, PTEN
platelet-derived growth factor receptor signaling pathway (GO:0048008)	NEW	6.15	0.0	ERBB2, POT1, TP53, PTEN
cardiac muscle tissue development (GO:0048738)	NEW	6.33	0.009	ERBB2, TP53, PTEN
positive regulation of transcription from RNA polymerase I promoter (GO:0045943)	NEW	7.09	0.043	ERBB2, TP53
regulation of helicase activity (GO:0051095)	-	7.53	0.007	POT1, TP53
lymphocyte differentiation (GO:0030098)	NEW	4.49	0.006	ERBB2, PTEN, PPARG, POT1, TP53
glycerophospholipid biosynthetic process (GO:0046474)	NEW	4.62	0.049	PTEN, PPARG, POT1, TP53
response to steroid hormone (GO:0048545)	NEW	4.24	0.01	IDH1, POT1, TP53, ERBB2, PTEN, PPARG
positive regulation of cytokine production (GO:0001819)	NEW	3.82	0.044	PPARG, ERBB2, POT1, TP53, PTEN
response to glucocorticoid (GO:0051384)	NEW	4.63	0.002	ERBB2, PTEN, PPARG, POT1, TP53
single organismal cell-cell adhesion (GO:0016337)	NEW	3.69	0.027	ERBB2, PTEN, PPARG, POT1, TP53
regulation of cytokine secretion (GO:0050707)	NEW	4.74	0.045	PPARG, POT1, TP53, PTEN
regulation of cellular carbohydrate metabolic process (GO:0010675)	NEW	4.81	0.002	PPARG, ERBB2, POT1, TP53, PTEN
regulation of smooth muscle cell migration (GO:0014910)	NEW	5.84	0.021	PPARG, TP53, PTEN
positive regulation of cell activation (GO:0050867)	NEW	3.97	0.001	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
extrinsic apoptotic signaling pathway (GO:0097191)	NEW	5.16	0.007	ERBB2, PPARG, PTEN, TP53
regulation of T cell activation (GO:0050863)	NEW	4.05	0.03	ERBB2, PTEN, PPARG, POT1, TP53
regulation of cell-cell adhesion (GO:0022407)	NEW	3.79	0.012	ERBB2, PPARG, PTEN, TP53
striated muscle tissue development (GO:0014706)	NEW	5.23	0.014	ERBB2, PPARG, PTEN, TP53
regulation of muscle cell differentiation (GO:0051147)	NEW	4.68	0.032	ERBB2, PPARG, PTEN, TP53
regulation of lipid biosynthetic process (GO:0046890)	NEW	4.87	0.032	ERBB2, PPARG, PTEN, TP53
pyridine-containing compound metabolic process (GO:0072524)	NEW	5.07	0.047	IDH1, POT1, TP53
regulation of cell division (GO:0051302)	NEW	4.88	0.018	PPARG, ERBB2, BRCA2, TP53, PTEN
regulation of DNA metabolic process (GO:0051052)	-	3.87	0.003	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.014	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
carboxylic acid metabolic process (GO:0019752)	-	3.12	0.015	IDH1, IDH2, POT1, TP53, ERBB2, PTEN, PPARG
chromatin organization (GO:0006325)	-	3.28	0.011	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
glyoxylate cycle (GO:0006097)	-	9.04	0.0	IDH1, IDH2
cellular response to organonitrogen compound (GO:0071417)	NEW	3.87	0.013	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
response to gamma radiation (GO:0010332)	-	5.78	0.024	BRCA2, PPARG, TP53
neuron projection morphogenesis (GO:0048812)	NEW	4.34	0.007	PPARG, ERBB2, POT1, TP53, PTEN
Type I pneumocyte differentiation (GO:0060509)	NEW	7.94	0.037	PPARG, TP53
positive regulation of epidermal cell differentiation (GO:0045606)	NEW	6.73	0.002	PPARG, POT1, TP53
hematopoietic or lymphoid organ development (GO:0048534)	NEW	4.49	0.006	BRCA2, ERBB2, PPARG, PTEN, TP53
response to organophosphorus (GO:0046683)	NEW	4.79	0.001	PPARG, ERBB2, POT1, TP53, PTEN
positive regulation of mitotic cell cycle (GO:0045931)	NEW	4.98	0.014	BRCA2, TP53, PTEN
negative regulation of cell migration (GO:0030336)	NEW	4.41	0.006	ERBB2, PTEN, PPARG, POT1, TP53
regulation of smooth muscle cell proliferation (GO:0048660)	NEW	5.1	0.005	ERBB2, PPARG, PTEN, TP53
regulation of steroid metabolic process (GO:0019218)	NEW	5.42	0.007	ERBB2, PPARG, TP53, PTEN
protein complex assembly (GO:0006461)	NEW	2.78	0.046	BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
regulation of mitotic cell cycle (GO:0007346)	-	3.71	0.005	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
signal release (GO:0023061)	NEW	4.65	0.001	ERBB2, PTEN, PPARG, POT1, TP53
response to ethanol (GO:0045471)	NEW	4.83	0.025	PPARG, POT1, TP53, PTEN
stress-activated MAPK cascade (GO:0051403)	NEW	5.45	0.003	ERBB2, POT1, TP53, PTEN
nucleotide metabolic process (GO:0009117)	NEW	3.73	0.025	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
reactive oxygen species metabolic process (GO:0072593)	NEW	5.14	0.006	ERBB2, PPARG, TP53, PTEN
cellular process involved in reproduction in multicellular organism (GO:0022412)	NEW	4.3	0.036	POT1, ERBB2, BRCA2, TP53, PTEN
regulation of protein secretion (GO:0050708)	NEW	3.77	0.007	ERBB2, PTEN, PPARG, POT1, TP53
monocarboxylic acid metabolic process (GO:0032787)	-	3.57	0.013	IDH1, POT1, IDH2, TP53, PTEN, PPARG
DNA damage response, signal transduction resulting in transcription (GO:0042772)	-	7.02	0.019	BRCA2, TP53
heart development (GO:0007507)	-	4.24	0.045	ERBB2, PPARG, PTEN
negative regulation of cellular component movement (GO:0051271)	NEW	4.22	0.008	PPARG, ERBB2, POT1, TP53, PTEN
carbohydrate metabolic process (GO:0005975)	-	3.26	0.004	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cell part morphogenesis (GO:0032990)	NEW	3.99	0.036	PPARG, ERBB2, POT1, TP53, PTEN
developmental process involved in reproduction (GO:0003006)	-	3.36	0.005	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
regulation of carbohydrate metabolic process (GO:0006109)	NEW	4.57	0.002	PPARG, ERBB2, POT1, TP53, PTEN
hormone transport (GO:0009914)	NEW	5.33	0.009	PPARG, POT1, TP53, PTEN
muscle tissue development (GO:0060537)	NEW	5.1	0.025	ERBB2, PPARG, TP53, PTEN
negative regulation of protein phosphorylation (GO:0001933)	NEW	3.79	0.038	PPARG, ERBB2, POT1, TP53, PTEN
positive regulation of behavior (GO:0048520)	NEW	6.47	0.035	PTEN, PPARG, POT1, TP53
lung epithelial cell differentiation (GO:0060487)	NEW	6.51	0.013	ERBB2, PPARG, TP53
pyridine nucleotide metabolic process (GO:0019362)	NEW	5.14	0.034	IDH1, POT1, TP53

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular membrane-bounded organelle (GO:0043231)	0.6	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cell part (GO:0044464)	0.11	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
intracellular organelle part (GO:0044446)	0.81	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
intracellular organelle (GO:0043229)	0.51	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
intracellular part (GO:0044424)	0.28	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
membrane-bounded organelle (GO:0043227)	0.47	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
organelle (GO:0043226)	0.4	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
organelle part (GO:0044422)	0.79	8	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
cytoplasmic part (GO:0044444)	0.82	7	IDH1, BRCA2, IDH2, TP53, ERBB2, PTEN, PPARG
cytoplasm (GO:0005737)	1.01	6	IDH1, BRCA2, TP53, ERBB2, PTEN, PPARG
nucleus (GO:0005634)	1.07	6	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
nucleoplasm (GO:0005654)	1.89	5	PPARG, POT1, BRCA2, TP53, PTEN
macromolecular complex (GO:0032991)	1.35	5	BRCA2, ERBB2, PPARG, POT1, TP53
cytosol (GO:0005829)	1.68	5	IDH2, IDH1, PPARG, TP53, PTEN
membrane (GO:0016020)	0.68	5	ERBB2, PTEN, BRCA2, TP53, IDH2
nuclear part (GO:0044428)	1.55	5	PPARG, POT1, BRCA2, TP53, PTEN
protein complex (GO:0043234)	1.51	4	BRCA2, ERBB2, PPARG, TP53
membrane part (GO:0044425)	0.95	4	ERBB2, BRCA2, TP53, PTEN
vesicle (GO:0031982)	1.64	4	ERBB2, BRCA2, IDH1, IDH2
mitochondrion (GO:0005739)	2.42	4	IDH2, IDH1, TP53, PTEN
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	3	BRCA2, POT1, TP53
organelle lumen (GO:0043233)	3.05	3	IDH1, TP53, IDH2
integral component of membrane (GO:0016021)	1.14	3	ERBB2, BRCA2, TP53
intracellular organelle lumen (GO:0070013)	3.05	3	IDH1, TP53, IDH2
membrane-enclosed lumen (GO:0031974)	3.05	3	IDH1, TP53, IDH2
membrane-bounded vesicle (GO:0031988)	1.71	3	IDH1, BRCA2, IDH2
nuclear chromosome part (GO:0044454)	3.67	3	BRCA2, POT1, TP53
non-membrane-bounded organelle (GO:0043228)	1.76	3	BRCA2, POT1, TP53
chromosomal part (GO:0044427)	3.18	3	BRCA2, POT1, TP53
intrinsic component of membrane (GO:0031224)	1.13	3	ERBB2, BRCA2, TP53
plasma membrane region (GO:0098590)	2.97	2	ERBB2, PTEN
chromosome, telomeric region (GO:0000781)	4.9	2	BRCA2, POT1
microbody (GO:0042579)	4.93	2	IDH1, IDH2
RNA polymerase II transcription factor complex (GO:0090575)	5.18	2	PPARG, TP53
nuclear chromosome, telomeric region (GO:0000784)	5.16	2	BRCA2, POT1
PML body (GO:0016605)	5.24	2	TP53, PTEN
nuclear body (GO:0016604)	3.94	2	TP53, PTEN
organelle membrane (GO:0031090)	1.97	2	ERBB2, IDH2
cytoplasmic vesicle (GO:0031410)	2.87	2	ERBB2, BRCA2
peroxisome (GO:0005777)	5.01	2	IDH1, IDH2
nuclear transcription factor complex (GO:0044798)	4.95	2	PPARG, TP53
nucleoplasm part (GO:0044451)	3.22	2	TP53, PTEN
mitochondrial matrix (GO:0005759)	4.03	2	TP53, IDH2
perinuclear region of cytoplasm (GO:0048471)	3.35	2	ERBB2, PPARG
plasma membrane part (GO:0044459)	1.95	2	ERBB2, PTEN
apical plasma membrane (GO:0016324)	4.13	2	ERBB2, PTEN
intracellular vesicle (GO:0097708)	2.86	2	ERBB2, BRCA2
plasma membrane (GO:0005886)	1.39	2	ERBB2, PTEN
extracellular vesicle (GO:1903561)	1.89	2	IDH1, IDH2
chromosomal region (GO:0098687)	4.19	2	BRCA2, POT1
extracellular exosome (GO:0070062)	1.89	2	IDH1, IDH2
extracellular organelle (GO:0043230)	1.89	2	IDH1, IDH2
mitochondrial part (GO:0044429)	2.92	2	TP53, IDH2
transcription factor complex (GO:0005667)	4.1	2	PPARG, TP53
extracellular region part (GO:0044421)	1.57	2	IDH1, IDH2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	NEW	4.46	0.029	ERBB2, PPARG, PTEN, TP53
membrane-enclosed lumen (GO:0031974)	-	3.05	0.001	IDH1, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
extrinsic component of membrane (GO:0019898)	NEW	4.51	0.002	PTEN, PPARG, POT1, TP53
chromatin (GO:0000785)	NEW	3.99	0.043	ERBB2, PPARG, TP53, PTEN
blood microparticle (GO:0072562)	NEW	4.88	0.005	PTEN, PPARG, POT1, TP53
cell-substrate adherens junction (GO:0005924)	NEW	3.83	0.005	ERBB2, PTEN, PPARG, POT1, TP53
focal adhesion (GO:0005925)	NEW	3.83	0.005	PPARG, ERBB2, POT1, TP53, PTEN
anchored component of membrane (GO:0031225)	NEW	4.77	0.013	ERBB2, PPARG, TP53, PTEN
synaptic membrane (GO:0097060)	NEW	4.22	0.045	ERBB2, POT1, TP53, PTEN
PML body (GO:0016605)	-	5.24	0.049	POT1, TP53, PTEN
postsynaptic membrane (GO:0045211)	NEW	4.47	0.021	ERBB2, POT1, TP53, PTEN
nucleolus (GO:0005730)	NEW	3.06	0.01	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cytoplasmic membrane-bounded vesicle (GO:0016023)	NEW	3.12	0.014	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cytoplasmic vesicle (GO:0031410)	-	2.87	0.033	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
mitochondrion (GO:0005739)	-	2.42	0.0	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
nuclear chromosome part (GO:0044454)	-	3.67	0.0	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cytoskeletal part (GO:0044430)	NEW	2.49	0.036	IDH1, BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
cell-substrate junction (GO:0030055)	NEW	3.82	0.005	ERBB2, PTEN, PPARG, POT1, TP53
Golgi lumen (GO:0005796)	NEW	5.28	0.032	ERBB2, TP53, PTEN
secretory granule (GO:0030141)	NEW	4.34	0.025	BRCA2, PPARG, POT1, TP53
anchoring junction (GO:0070161)	NEW	3.61	0.014	ERBB2, PTEN, PPARG, POT1, TP53
secretory granule membrane (GO:0030667)	NEW	5.5	0.013	PPARG, TP53, PTEN
basolateral plasma membrane (GO:0016323)	NEW	4.56	0.011	ERBB2, PPARG, POT1, TP53
cytoplasmic vesicle membrane (GO:0030659)	NEW	3.67	0.025	PPARG, ERBB2, POT1, TP53, PTEN
adherens junction (GO:0005912)	NEW	3.66	0.012	ERBB2, PTEN, PPARG, POT1, TP53
vesicle membrane (GO:0012506)	NEW	3.63	0.028	ERBB2, PTEN, PPARG, POT1, TP53
axolemma (GO:0030673)	NEW	7.16	0.026	ERBB2, TP53
dendritic spine (GO:0043197)	NEW	5.06	0.047	ERBB2, POT1, PTEN
organelle lumen (GO:0043233)	-	3.05	0.0	IDH1, IDH2, POT1, TP53, ERBB2, PTEN, PPARG
intracellular organelle part (GO:0044446)	-	0.81	0.028	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
intracellular organelle lumen (GO:0070013)	-	3.05	0.0	IDH1, IDH2, POT1, TP53, ERBB2, PTEN, PPARG
chromosomal part (GO:0044427)	-	3.18	0.003	BRCA2, POT1, TP53, ERBB2, PTEN, PPARG
proteinaceous extracellular matrix (GO:0005578)	NEW	4.01	0.035	ERBB2, PPARG, TP53, PTEN
organelle part (GO:0044422)	-	0.79	0.035	IDH1, BRCA2, POT1, IDH2, TP53, ERBB2, PTEN, PPARG
endomembrane system (GO:0012505)	NEW	4.84	0.008	PPARG, TP53, PTEN