| Disease ID | Disease name | Source of annotation with INS | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 606176 | DIABETES MELLITUS, PERMANENT NEONATAL | ClinVar, OMIM, HUMSAVAR | link to OMIM | 4 | GCK, INS, ABCC8, KCNJ11 |
| 125852 | DIABETES MELLITUS, INSULIN-DEPENDENT, 2 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | INS |
| 613370 | MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | INS |
| 616214 | HYPERPROINSULINEMIA | OMIM, HUMSAVAR | link to OMIM | 1 | INS |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| cGMP-PKG signaling pathway | hsa04022 | 5.32 |
| Prostate cancer | hsa05215 | 6.11 |
| Regulation of autophagy | hsa04140 | 7.48 |
| FoxO signaling pathway | hsa04068 | 5.63 |
| HIF-1 signaling pathway | hsa04066 | 5.9 |
| Type I diabetes mellitus | hsa04940 | 6.79 |
| Aldosterone-regulated sodium reabsorption | hsa04960 | 7.41 |
| AMPK signaling pathway | hsa04152 | 5.8 |
| mTOR signaling pathway | hsa04150 | 6.72 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| Oocyte meiosis | hsa04114 | 5.91 |
| Ovarian steroidogenesis | hsa04913 | 7.07 |
| Rap1 signaling pathway | hsa04015 | 4.97 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Prolactin signaling pathway | hsa04917 | 6.6 |
| Progesterone-mediated oocyte maturation | hsa04914 | 6.18 |
| Type II diabetes mellitus | hsa04930 | 7.12 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| Maturity onset diabetes of the young | hsa04950 | 8.07 |
| Insulin signaling pathway | hsa04910 | 5.55 |
| Insulin secretion | hsa04911 | 6.18 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| IRS activation | R-HSA-74713 | 10.66 |
| Regulation of gene expression in beta cells | R-HSA-210745 | 8.66 |
| Regulation of insulin secretion | R-HSA-422356 | 6.66 |
| Regulation of beta-cell development | R-HSA-186712 | 7.98 |
| Insulin processing | R-HSA-264876 | 8.28 |
| Insulin receptor recycling | R-HSA-77387 | 8.28 |
| Integration of energy metabolism | R-HSA-163685 | 6.24 |
| Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
| Signal attenuation | R-HSA-74749 | 9.66 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.89 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| Signaling by Insulin receptor | R-HSA-74752 | 4.73 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| Insulin receptor signalling cascade | R-HSA-74751 | 4.85 |
| GO term | GO ID | GO IC |
|---|---|---|
| hormone activity | GO:0005179 | 4.95 |
| protein binding | GO:0005515 | 0.46 |
| insulin-like growth factor receptor binding | GO:0005159 | 7.03 |
| insulin receptor binding | GO:0005158 | 6.27 |
| enzyme binding | GO:0019899 | 2.27 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protease binding | GO:0002020 | 5.08 |
| protein complex binding | GO:0032403 | 3.09 |
| receptor binding | GO:0005102 | 2.43 |
| identical protein binding | GO:0042802 | 2.63 |