Gene table of GCK : glucokinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with GCK	OMIM link	Number of associated genes	genes
PS256450	HYPERINSULINEMIA HYPOGLYCEMIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	GCK, INSR, SLC16A1, GLUD1, HADH, ABCC8, KCNJ11
125853	DIABETES MELLITUS, NONINSULIN-DEPENDENT	OMIM	link to OMIM	33	SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11
125851	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 2	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	GCK
606176	DIABETES MELLITUS, PERMANENT NEONATAL	ClinVar, OMIM	link to OMIM	4	ABCC8, INS, GCK, KCNJ11

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Annotation of the gene GCK

Associated genes in ENSEMBL

ENSG00000106633

Associated proteins - SwissProt Accession ID

P35557

Associated PDB IDs

Cytogenetic Band

7p13

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Butirosin and neomycin biosynthesis	hsa00524	10.45
Maturity onset diabetes of the young	hsa04950	8.07
Metabolic pathways	hsa01100	2.49
Prolactin signaling pathway	hsa04917	6.6
Carbon metabolism	hsa01200	6.03
Insulin signaling pathway	hsa04910	5.55
Insulin secretion	hsa04911	6.18
Central carbon metabolism in cancer	hsa05230	6.7
Galactose metabolism	hsa00052	7.72
Starch and sucrose metabolism	hsa00500	6.91
Glycolysis / Gluconeogenesis	hsa00010	6.64
Type II diabetes mellitus	hsa04930	7.12
Amino sugar and nucleotide sugar metabolism	hsa00520	7.15

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Regulation of gene expression in beta cells	R-HSA-210745	8.66
Regulation of beta-cell development	R-HSA-186712	7.98
Glucose metabolism	R-HSA-70326	6.77
Regulation of Glucokinase by Glucokinase Regulatory Protein	R-HSA-170822	8.12
Hexose transport	R-HSA-189200	7.43
Glycolysis	R-HSA-70171	8.03
Metabolism	R-HSA-1430728	2.34
Transmembrane transport of small molecules	R-HSA-382551	3.79
SLC-mediated transmembrane transport	R-HSA-425407	4.95
Glucose transport	R-HSA-70153	7.62
Developmental Biology	R-HSA-1266738	3.48
Metabolism of carbohydrates	R-HSA-71387	4.93

Associated GO terms for Molecular function

GO term	GO ID	GO IC
carbohydrate kinase activity	GO:0019200	6.74
purine ribonucleoside triphosphate binding	GO:0035639	2.22
fructokinase activity	GO:0008865	8.13
hexokinase activity	GO:0004396	8.13
carbohydrate binding	GO:0030246	4.17
enzyme binding	GO:0019899	2.27
monosaccharide binding	GO:0048029	5.85
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
magnesium ion binding	GO:0000287	4.41
glucokinase activity	GO:0004340	8.13
ion binding	GO:0043167	1.36
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
mannokinase activity	GO:0019158	8.13
ADP binding	GO:0043531	6.24
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
glucose binding	GO:0005536	7.25
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
binding	GO:0005488	0.18