Disease table of DIABETES MELLITUS, PERMANENT NEONATAL OMIM ID: 606176

Gene-disease associations table

GeneAssociated with DIABETES MELLITUS, PERMANENT NEONATAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GCKClinVar, OMIMHGNC link7p134125851, PS256450, 606176, 125853
ABCC8ClinVar, OMIM, HUMSAVARHGNC link11p15.15240800, 610374, 606176, PS256450, 125853
KCNJ11ClinVar, OMIM, HUMSAVARHGNC link11p15.15610582, 606176, 616329, PS256450, 125853
INSClinVar, OMIM, HUMSAVARHGNC link11p15.54613370, 125852, 606176, 616214

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
11p15.12KCNJ11, ABCC8
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
11p153KCNJ11, ABCC8, INS
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
11p13KCNJ11, ABCC8, INS
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
11p3KCNJ11, ABCC8, INS
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
113KCNJ11, ABCC8, INS
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HNF4ANO43GPR39, TBP, CYP2C9, CEACAM1, KCNJ11, LDLR, SHBG, APOA1, UGT2B7, MMP7, CYP7A1, HNF1A, ABCC6, SERPINC1, GH1, PCSK9, CYP2B6, NR1I2, CYP2D6, ABCG8, PPARA, APOB, ABCG5, CDKN1A, AFP, CYP27A1, ACMSD, SLC26A3, RNASE2, SLC22A6, UGT1A7, AKR1C4, GCK, NPC1L1, C1QTNF5, APOA2, APOC3, ACAT2, CYP2C8, FABP2, GFER, MYC, LIPC2KCNJ11, GCK
PDX1NO3INS, SLC2A2, GCK2INS, GCK
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GCKYES5HNF4A, HIF1A, PDX1, PAX6, USF10
KCNJ11YES1HNF4A0
INSYES9GLIS3, PAX4, NEUROD1, NR1H4, KLF11, PDX1, TCF3, MAFA, ATF20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ABCC8KCNJ11Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
GCKABCC8No-2INS, FOXA2
GCKKCNJ11No-1FOXA2
GCKINSYesactivation, binding6PDX1, NEUROD1, ATF3, INPPL1, FOXA2, HIF1A
ABCC8KCNJ11Yesbinding8RAPGEF4, HSP90AA1, PRKACG, FOXA2, RAPGEF3, PRKACA, KCNJ8, PRKACB
ABCC8INSYesactivation, binding, ptmod1FOXA2
KCNJ11INSNo-4GAPDH, FOXA2, ABCC8, ISL1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Insulin secretionhsa049116.184INS, KCNJ11, GCK, ABCC8
Type II diabetes mellitushsa049307.124INS, KCNJ11, GCK, ABCC8
Insulin signaling pathwayhsa049105.552INS, GCK
Prolactin signaling pathwayhsa049176.62INS, GCK
Maturity onset diabetes of the younghsa049508.072INS, GCK

NET-GE enrichment

Term New enriched termICP valueGenes
ABC transporters (hsa02010) NEW7.280.039INS, ABCC8
Endocrine and metabolic diseasesNEW4.750.003INS, KCNJ11, ABCC8, GCK
Maturity onset diabetes of the young (hsa04950) -8.070.004INS, GCK
cGMP-PKG signaling pathway (hsa04022) NEW5.320.039INS, KCNJ11, ABCC8
Membrane transportNEW7.280.039INS, ABCC8
Insulin secretion (hsa04911) -6.180.0INS, KCNJ11, GCK, ABCC8
Endocrine systemNEW3.260.006INS, KCNJ11, ABCC8, GCK
Biosynthesis of other secondary metabolitesNEW9.450.004INS, GCK
Galactose metabolism (hsa00052) NEW7.720.027INS, GCK
Type II diabetes mellitus (hsa04930) -7.120.0INS, KCNJ11, GCK, ABCC8
Prolactin signaling pathway (hsa04917) -6.60.031INS, GCK
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.344INS, KCNJ11, GCK, ABCC8
Regulation of insulin secretionR-HSA-4223566.663INS, KCNJ11, ABCC8
Integration of energy metabolismR-HSA-1636856.243INS, KCNJ11, ABCC8
Transmembrane transport of small moleculesR-HSA-3825513.793KCNJ11, ABCC8, GCK
Inwardly rectifying K+ channelsR-HSA-12960658.032KCNJ11, ABCC8
Regulation of gene expression in beta cellsR-HSA-2107458.662INS, GCK
Regulation of beta-cell developmentR-HSA-1867127.982INS, GCK
Potassium ChannelsR-HSA-12960716.352KCNJ11, ABCC8
ABC-family proteins mediated transportR-HSA-3825567.592KCNJ11, ABCC8
Neuronal SystemR-HSA-1123164.822KCNJ11, ABCC8
ATP sensitive Potassium channelsR-HSA-129602510.982KCNJ11, ABCC8
Developmental BiologyR-HSA-12667383.482INS, GCK

NET-GE enrichment

Term New enriched termICP valueGenes
Inwardly rectifying K+ channels (R-HSA-1296065) -8.030.003KCNJ11, ABCC8
Regulation of gene expression in beta cells (R-HSA-210745) -8.660.001INS, GCK
Regulation of insulin secretion (R-HSA-422356) -6.660.004INS, KCNJ11, ABCC8
Regulation of beta-cell development (R-HSA-186712) -7.980.003INS, GCK
Potassium Channels (R-HSA-1296071) -6.350.026KCNJ11, ABCC8
ABC-family proteins mediated transport (R-HSA-382556) -7.590.0INS, KCNJ11, ABCC8
Integration of energy metabolism (R-HSA-163685) -6.240.0INS, KCNJ11, ABCC8
Transmembrane transport of small molecules (R-HSA-382551) -3.790.043KCNJ11, ABCC8, GCK
Hexose transport (R-HSA-189200) NEW7.430.045INS, GCK
Glycolysis (R-HSA-70171) NEW8.030.021INS, GCK
Metabolism (R-HSA-1430728) -2.340.046INS, KCNJ11, GCK, ABCC8
Glucose transport (R-HSA-70153) NEW7.620.03INS, GCK
ATP sensitive Potassium channels (R-HSA-1296025) -10.980.0KCNJ11, ABCC8
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184INS, KCNJ11, ABCC8, GCK
protein binding (GO:0005515) 0.464INS, KCNJ11, ABCC8, GCK
adenyl nucleotide binding (GO:0030554) 2.43KCNJ11, ABCC8, GCK
carbohydrate derivative binding (GO:0097367) 2.033KCNJ11, ABCC8, GCK
organic cyclic compound binding (GO:0097159) 1.053KCNJ11, ABCC8, GCK
nucleoside phosphate binding (GO:1901265) 1.963KCNJ11, ABCC8, GCK
nucleotide binding (GO:0000166) 1.963KCNJ11, ABCC8, GCK
small molecule binding (GO:0036094) 1.893KCNJ11, GCK, ABCC8
purine ribonucleoside triphosphate binding (GO:0035639) 2.223KCNJ11, GCK, ABCC8
purine ribonucleoside binding (GO:0032550) 2.223KCNJ11, ABCC8, GCK
adenyl ribonucleotide binding (GO:0032559) 2.413KCNJ11, ABCC8, GCK
ribonucleotide binding (GO:0032553) 2.193KCNJ11, ABCC8, GCK
purine nucleoside binding (GO:0001883) 2.223KCNJ11, ABCC8, GCK
ribonucleoside binding (GO:0032549) 2.223KCNJ11, GCK, ABCC8
purine ribonucleotide binding (GO:0032555) 2.23KCNJ11, ABCC8, GCK
purine nucleotide binding (GO:0017076) 2.193KCNJ11, GCK, ABCC8
heterocyclic compound binding (GO:1901363) 1.063KCNJ11, ABCC8, GCK
ATP binding (GO:0005524) 2.433KCNJ11, GCK, ABCC8
nucleoside binding (GO:0001882) 2.213KCNJ11, GCK, ABCC8
potassium channel activity (GO:0005267) 4.942KCNJ11, ABCC8
cation channel activity (GO:0005261) 4.042KCNJ11, ABCC8
enzyme binding (GO:0019899) 2.272INS, GCK
molecular transducer activity (GO:0060089) 2.322KCNJ11, ABCC8
receptor activity (GO:0004872) 2.322KCNJ11, ABCC8
ion channel binding (GO:0044325) 5.022KCNJ11, ABCC8
substrate-specific channel activity (GO:0022838) 3.672KCNJ11, ABCC8
cation binding (GO:0043169) 1.42KCNJ11, GCK
ATP-activated inward rectifier potassium channel activity (GO:0015272) 8.132KCNJ11, ABCC8
ligand-gated ion channel activity (GO:0015276) 4.82KCNJ11, ABCC8
ion binding (GO:0043167) 1.362KCNJ11, GCK
transmembrane transporter activity (GO:0022857) 2.822KCNJ11, ABCC8
voltage-gated cation channel activity (GO:0022843) 4.832KCNJ11, ABCC8
passive transmembrane transporter activity (GO:0022803) 3.62KCNJ11, ABCC8
metal ion transmembrane transporter activity (GO:0046873) 3.712KCNJ11, ABCC8
metal ion binding (GO:0046872) 1.412KCNJ11, GCK
transporter activity (GO:0005215) 2.572KCNJ11, ABCC8
ion channel activity (GO:0005216) 3.712KCNJ11, ABCC8
cation transmembrane transporter activity (GO:0008324) 3.322KCNJ11, ABCC8
catalytic activity (GO:0003824) 1.052ABCC8, GCK
substrate-specific transmembrane transporter activity (GO:0022891) 2.92KCNJ11, ABCC8
inorganic cation transmembrane transporter activity (GO:0022890) 3.492KCNJ11, ABCC8
substrate-specific transporter activity (GO:0022892) 2.722KCNJ11, ABCC8
ion transmembrane transporter activity (GO:0015075) 3.042KCNJ11, ABCC8
voltage-gated channel activity (GO:0022832) 4.492KCNJ11, ABCC8
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.872KCNJ11, ABCC8
channel activity (GO:0015267) 3.62KCNJ11, ABCC8
gated channel activity (GO:0022836) 3.962KCNJ11, ABCC8
voltage-gated potassium channel activity (GO:0005249) 5.242KCNJ11, ABCC8
ligand-gated channel activity (GO:0022834) 4.82KCNJ11, ABCC8
voltage-gated ion channel activity (GO:0005244) 4.492KCNJ11, ABCC8
potassium ion transmembrane transporter activity (GO:0015079) 4.772KCNJ11, ABCC8
inward rectifier potassium channel activity (GO:0005242) 6.652KCNJ11, ABCC8
transmembrane receptor activity (GO:0099600) 2.532KCNJ11, ABCC8

NET-GE enrichment

Term New enriched termICP valueGenes
potassium channel activity (GO:0005267) -4.940.003INS, KCNJ11, ABCC8
voltage-gated potassium channel activity (GO:0005249) -5.240.001INS, KCNJ11, ABCC8
ligand-gated ion channel activity (GO:0015276) -4.80.009INS, KCNJ11, ABCC8
ADP binding (GO:0043531) NEW6.240.011INS, GCK
ligand-gated channel activity (GO:0022834) -4.80.009INS, KCNJ11, ABCC8
ion channel binding (GO:0044325) -5.020.011INS, KCNJ11, ABCC8
potassium ion transmembrane transporter activity (GO:0015079) -4.770.004INS, KCNJ11, ABCC8
inward rectifier potassium channel activity (GO:0005242) -6.650.012KCNJ11, ABCC8
carbohydrate kinase activity (GO:0019200) NEW6.740.007INS, GCK
glucose binding (GO:0005536) NEW7.250.001INS, GCK
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of peptide transport (GO:0090087) 4.374INS, KCNJ11, GCK, ABCC8
regulation of secretion (GO:0051046) 3.24INS, KCNJ11, ABCC8, GCK
negative regulation of secretion (GO:0051048) 4.444INS, KCNJ11, GCK, ABCC8
regulation of transport (GO:0051049) 2.244INS, KCNJ11, ABCC8, GCK
negative regulation of signaling (GO:0023057) 2.654INS, KCNJ11, GCK, ABCC8
negative regulation of secretion by cell (GO:1903531) 4.554INS, KCNJ11, GCK, ABCC8
regulation of secretion by cell (GO:1903530) 3.284INS, KCNJ11, GCK, ABCC8
regulation of signaling (GO:0023051) 1.724INS, KCNJ11, ABCC8, GCK
regulation of protein transport (GO:0051223) 3.124INS, KCNJ11, GCK, ABCC8
regulation of biological process (GO:0050789) 0.454INS, KCNJ11, GCK, ABCC8
single-organism process (GO:0044699) 0.484INS, KCNJ11, GCK, ABCC8
regulation of protein localization (GO:0032880) 2.884INS, KCNJ11, ABCC8, GCK
response to endogenous stimulus (GO:0009719) 2.794INS, KCNJ11, GCK, ABCC8
regulation of localization (GO:0032879) 1.944INS, KCNJ11, GCK, ABCC8
regulation of protein secretion (GO:0050708) 3.774INS, KCNJ11, ABCC8, GCK
regulation of hormone levels (GO:0010817) 3.564INS, KCNJ11, GCK, ABCC8
regulation of cell communication (GO:0010646) 1.734INS, KCNJ11, GCK, ABCC8
response to nitrogen compound (GO:1901698) 3.124INS, KCNJ11, GCK, ABCC8
localization (GO:0051179) 1.44INS, KCNJ11, GCK, ABCC8
biological regulation (GO:0065007) 0.394INS, KCNJ11, GCK, ABCC8
positive regulation of biological process (GO:0048518) 1.24INS, KCNJ11, ABCC8, GCK
negative regulation of biological process (GO:0048519) 1.334INS, KCNJ11, ABCC8, GCK
regulation of biological quality (GO:0065008) 1.684INS, KCNJ11, GCK, ABCC8
regulation of establishment of protein localization (GO:0070201) 3.024INS, KCNJ11, GCK, ABCC8
cellular process (GO:0009987) 0.264INS, KCNJ11, GCK, ABCC8
negative regulation of transport (GO:0051051) 3.64INS, KCNJ11, GCK, ABCC8
positive regulation of transport (GO:0051050) 2.94INS, KCNJ11, ABCC8, GCK
transport (GO:0006810) 1.514INS, KCNJ11, ABCC8, GCK
regulation of cellular process (GO:0050794) 0.54INS, KCNJ11, ABCC8, GCK
single-organism transport (GO:0044765) 2.184INS, KCNJ11, ABCC8, GCK
regulation of hormone secretion (GO:0046883) 4.184INS, KCNJ11, GCK, ABCC8
single-organism cellular process (GO:0044763) 0.654INS, KCNJ11, ABCC8, GCK
response to chemical (GO:0042221) 1.984INS, KCNJ11, ABCC8, GCK
establishment of localization (GO:0051234) 1.484INS, KCNJ11, ABCC8, GCK
response to organic substance (GO:0010033) 2.24INS, KCNJ11, GCK, ABCC8
single-organism localization (GO:1902578) 2.094INS, KCNJ11, ABCC8, GCK
response to oxygen-containing compound (GO:1901700) 2.574INS, KCNJ11, ABCC8, GCK
regulation of peptide secretion (GO:0002791) 4.384INS, KCNJ11, GCK, ABCC8
response to stimulus (GO:0050896) 1.224INS, KCNJ11, GCK, ABCC8
regulation of peptide hormone secretion (GO:0090276) 4.414INS, KCNJ11, ABCC8, GCK
response to organonitrogen compound (GO:0010243) 3.24INS, KCNJ11, GCK, ABCC8
negative regulation of cellular process (GO:0048523) 1.414INS, KCNJ11, ABCC8, GCK
negative regulation of cell communication (GO:0010648) 2.664INS, KCNJ11, ABCC8, GCK
homeostatic process (GO:0042592) 2.613INS, KCNJ11, GCK
glucose homeostasis (GO:0042593) 4.63INS, KCNJ11, GCK
small molecule metabolic process (GO:0044281) 2.383INS, KCNJ11, GCK
cellular response to chemical stimulus (GO:0070887) 2.573KCNJ11, GCK, ABCC8
negative regulation of establishment of protein localization (GO:1904950) 4.393INS, KCNJ11, ABCC8
single-organism carbohydrate metabolic process (GO:0044723) 3.423INS, KCNJ11, GCK
regulation of ion transport (GO:0043269) 3.43KCNJ11, ABCC8, GCK
cellular response to stimulus (GO:0051716) 1.973KCNJ11, ABCC8, GCK
negative regulation of protein secretion (GO:0050709) 5.063INS, KCNJ11, ABCC8
negative regulation of protein transport (GO:0051224) 4.443INS, KCNJ11, ABCC8
carbohydrate homeostasis (GO:0033500) 4.63INS, KCNJ11, GCK
organic substance metabolic process (GO:0071704) 0.633INS, KCNJ11, GCK
cellular response to organic substance (GO:0071310) 2.783KCNJ11, GCK, ABCC8
cation transport (GO:0006812) 3.113KCNJ11, GCK, ABCC8
ion transport (GO:0006811) 2.663KCNJ11, GCK, ABCC8
hexose metabolic process (GO:0019318) 4.643INS, KCNJ11, GCK
single-organism metabolic process (GO:0044710) 1.633INS, KCNJ11, GCK
regulation of insulin secretion (GO:0050796) 4.573KCNJ11, GCK, ABCC8
response to stress (GO:0006950) 1.83INS, KCNJ11, GCK
metal ion transport (GO:0030001) 3.363KCNJ11, ABCC8, GCK
metabolic process (GO:0008152) 0.583INS, KCNJ11, GCK
negative regulation of hormone secretion (GO:0046888) 5.413KCNJ11, GCK, ABCC8
primary metabolic process (GO:0044238) 0.693INS, KCNJ11, GCK
carbohydrate metabolic process (GO:0005975) 3.263INS, KCNJ11, GCK
monosaccharide metabolic process (GO:0005996) 4.573INS, KCNJ11, GCK
chemical homeostasis (GO:0048878) 2.973INS, KCNJ11, GCK
glucose metabolic process (GO:0006006) 4.943INS, KCNJ11, GCK
signal transduction (GO:0007165) 1.283INS, ABCC8, GCK
regulation of phosphate metabolic process (GO:0019220) 2.352INS, GCK
regulation of primary metabolic process (GO:0080090) 1.082INS, GCK
regulation of metabolic process (GO:0019222) 1.022INS, GCK
positive regulation of secretion (GO:0051047) 3.852INS, GCK
negative regulation of cellular carbohydrate metabolic process (GO:0010677) 5.882INS, GCK
regulation of ATP metabolic process (GO:1903578) 5.822INS, GCK
positive regulation of nucleotide metabolic process (GO:0045981) 4.852INS, GCK
regulation of glucan biosynthetic process (GO:0010962) 6.332INS, GCK
positive regulation of ATP metabolic process (GO:1903580) 6.552INS, GCK
positive regulation of macromolecule metabolic process (GO:0010604) 1.812INS, GCK
positive regulation of molecular function (GO:0044093) 2.232INS, KCNJ11
inorganic cation transmembrane transport (GO:0098662) 3.552KCNJ11, ABCC8
cellular homeostasis (GO:0019725) 3.232KCNJ11, GCK
regulation of phosphorylation (GO:0042325) 2.52INS, GCK
regulation of macromolecule metabolic process (GO:0060255) 1.082INS, GCK
inorganic ion transmembrane transport (GO:0098660) 3.382KCNJ11, ABCC8
positive regulation of phosphorylation (GO:0042327) 2.92INS, GCK
positive regulation of peptide hormone secretion (GO:0090277) 5.262INS, GCK
positive regulation of glycogen biosynthetic process (GO:0045725) 7.022INS, GCK
response to peptide hormone (GO:0043434) 4.062ABCC8, GCK
regulation of glycogen metabolic process (GO:0070873) 6.172INS, GCK
negative regulation of peptide hormone secretion (GO:0090278) 5.882KCNJ11, ABCC8
positive regulation of glycogen metabolic process (GO:0070875) 6.92INS, GCK
system process (GO:0003008) 2.32INS, KCNJ11
regulation of coenzyme metabolic process (GO:0051196) 5.82INS, GCK
positive regulation of coenzyme metabolic process (GO:0051197) 7.022INS, GCK
positive regulation of cofactor metabolic process (GO:0051194) 7.022INS, GCK
regulation of cofactor metabolic process (GO:0051193) 5.82INS, GCK
response to external stimulus (GO:0009605) 2.552ABCC8, GCK
response to monosaccharide (GO:0034284) 4.772KCNJ11, GCK
positive regulation of glycolytic process (GO:0045821) 7.092INS, GCK
positive regulation of catabolic process (GO:0009896) 3.942INS, GCK
regulation of catabolic process (GO:0009894) 3.522INS, GCK
negative regulation of metabolic process (GO:0009892) 1.932INS, GCK
positive regulation of metabolic process (GO:0009893) 1.742INS, GCK
negative regulation of biosynthetic process (GO:0009890) 2.472INS, GCK
positive regulation of biosynthetic process (GO:0009891) 2.292INS, GCK
regulation of glucose metabolic process (GO:0010906) 5.082INS, GCK
positive regulation of glucose metabolic process (GO:0010907) 6.152INS, GCK
intracellular signal transduction (GO:0035556) 2.392INS, GCK
positive regulation of cell communication (GO:0010647) 2.412INS, GCK
cellular macromolecule metabolic process (GO:0044260) 0.932INS, GCK
hexose transport (GO:0008645) 5.762INS, GCK
carbohydrate transport (GO:0008643) 5.162INS, GCK
regulation of transmembrane transport (GO:0034762) 3.742INS, KCNJ11
regulation of glycolytic process (GO:0006110) 6.262INS, GCK
regulation of gluconeogenesis (GO:0006111) 6.072INS, GCK
positive regulation of carbohydrate metabolic process (GO:0045913) 5.42INS, GCK
negative regulation of carbohydrate metabolic process (GO:0045912) 5.762INS, GCK
regulation of molecular function (GO:0065009) 1.782INS, KCNJ11
negative regulation of gluconeogenesis (GO:0045721) 7.162INS, GCK
potassium ion transport (GO:0006813) 4.682KCNJ11, ABCC8
regulation of biosynthetic process (GO:0009889) 1.372INS, GCK
regulation of blood circulation (GO:1903522) 4.052INS, KCNJ11
regulation of multicellular organismal process (GO:0051239) 1.872INS, KCNJ11
regulation of carbohydrate biosynthetic process (GO:0043255) 5.252INS, GCK
regulation of phosphorus metabolic process (GO:0051174) 2.352INS, GCK
regulation of system process (GO:0044057) 3.532INS, KCNJ11
positive regulation of protein secretion (GO:0050714) 4.392INS, GCK
regulation of transmembrane transporter activity (GO:0022898) 4.522INS, KCNJ11
cellular response to nitrogen compound (GO:1901699) 3.792KCNJ11, GCK
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392INS, GCK
regulation of macromolecule biosynthetic process (GO:0010556) 1.432INS, GCK
regulation of carbohydrate metabolic process (GO:0006109) 4.572INS, GCK
cellular glucose homeostasis (GO:0001678) 5.482KCNJ11, GCK
phosphorylation (GO:0016310) 2.632INS, GCK
positive regulation of signaling (GO:0023056) 2.412INS, GCK
negative regulation of insulin secretion (GO:0046676) 5.992KCNJ11, ABCC8
positive regulation of secretion by cell (GO:1903532) 3.932INS, GCK
regulation of polysaccharide biosynthetic process (GO:0032885) 6.092INS, GCK
positive regulation of establishment of protein localization (GO:1904951) 3.492INS, GCK
regulation of polysaccharide metabolic process (GO:0032881) 5.972INS, GCK
cellular potassium ion transport (GO:0071804) 4.792KCNJ11, ABCC8
potassium ion transmembrane transport (GO:0071805) 4.792KCNJ11, ABCC8
positive regulation of phosphorus metabolic process (GO:0010562) 2.782INS, GCK
regulation of transporter activity (GO:0032409) 4.452INS, KCNJ11
positive regulation of nucleoside metabolic process (GO:0045979) 6.552INS, GCK
monovalent inorganic cation transport (GO:0015672) 3.742KCNJ11, ABCC8
cellular response to endogenous stimulus (GO:0071495) 3.332KCNJ11, GCK
multicellular organismal process (GO:0032501) 1.452INS, KCNJ11
cellular response to oxygen-containing compound (GO:1901701) 3.222KCNJ11, GCK
positive regulation of cellular catabolic process (GO:0031331) 4.152INS, GCK
lipid homeostasis (GO:0055088) 5.02INS, GCK
regulation of cellular carbohydrate metabolic process (GO:0010675) 4.812INS, GCK
positive regulation of cellular carbohydrate metabolic process (GO:0010676) 5.722INS, GCK
positive regulation of hormone secretion (GO:0046887) 4.982INS, GCK
cellular chemical homeostasis (GO:0055082) 3.42KCNJ11, GCK
transmembrane transport (GO:0055085) 2.722KCNJ11, ABCC8
positive regulation of purine nucleotide metabolic process (GO:1900544) 4.852INS, GCK
regulation of carbohydrate catabolic process (GO:0043470) 5.972INS, GCK
response to hormone (GO:0009725) 3.332ABCC8, GCK
response to drug (GO:0042493) 3.712KCNJ11, ABCC8
macromolecule metabolic process (GO:0043170) 0.832INS, GCK
regulation of cellular catabolic process (GO:0031329) 3.832INS, GCK
positive regulation of cellular biosynthetic process (GO:0031328) 2.32INS, GCK
negative regulation of cellular biosynthetic process (GO:0031327) 2.492INS, GCK
regulation of cellular biosynthetic process (GO:0031326) 1.382INS, GCK
positive regulation of cellular metabolic process (GO:0031325) 1.812INS, GCK
negative regulation of cellular metabolic process (GO:0031324) 2.012INS, GCK
regulation of cellular metabolic process (GO:0031323) 1.072INS, GCK
regulation of potassium ion transport (GO:0043266) 5.312ABCC8, GCK
regulation of glucose transport (GO:0010827) 5.122INS, GCK
response to insulin (GO:0032868) 4.722ABCC8, GCK
positive regulation of protein transport (GO:0051222) 3.612INS, GCK
regulation of generation of precursor metabolites and energy (GO:0043467) 5.242INS, GCK
response to lipid (GO:0033993) 3.112KCNJ11, ABCC8
cellular response to organonitrogen compound (GO:0071417) 3.872KCNJ11, GCK
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462INS, GCK
glucose transport (GO:0015758) 5.82INS, GCK
organic substance transport (GO:0071702) 2.152INS, GCK
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352INS, GCK
positive regulation of phosphate metabolic process (GO:0045937) 2.782INS, GCK
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432INS, GCK
regulation of metal ion transport (GO:0010959) 3.942ABCC8, GCK
ion transmembrane transport (GO:0034220) 3.082KCNJ11, ABCC8
regulation of nitrogen compound metabolic process (GO:0051171) 1.362INS, GCK
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292INS, GCK
cell communication (GO:0007154) 3.042INS, GCK
regulation of nucleoside metabolic process (GO:0009118) 5.822INS, GCK
response to hexose (GO:0009746) 4.822KCNJ11, GCK
positive regulation of ion transport (GO:0043270) 4.362KCNJ11, ABCC8
regulation of purine nucleotide metabolic process (GO:1900542) 4.412INS, GCK
response to carbohydrate (GO:0009743) 4.622KCNJ11, GCK
regulation of glycogen biosynthetic process (GO:0005979) 6.332INS, GCK
negative regulation of peptide secretion (GO:0002792) 5.842KCNJ11, ABCC8
positive regulation of peptide secretion (GO:0002793) 5.222INS, GCK
cellular metabolic process (GO:0044237) 0.692INS, GCK
response to glucose (GO:0009749) 4.862KCNJ11, GCK
phosphate-containing compound metabolic process (GO:0006796) 2.162INS, GCK
response to peptide (GO:1901652) 3.942ABCC8, GCK
monosaccharide transport (GO:0015749) 5.762INS, GCK
phosphorus metabolic process (GO:0006793) 2.152INS, GCK
regulation of nucleotide metabolic process (GO:0006140) 4.382INS, GCK
cation transmembrane transport (GO:0098655) 3.432KCNJ11, ABCC8
positive regulation of cellular process (GO:0048522) 1.32INS, GCK

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of peptide transport (GO:0090087) -4.370.0INS, KCNJ11, ABCC8, GCK
cellular glucose homeostasis (GO:0001678) -5.480.003INS, KCNJ11, GCK
regulation of secretion (GO:0051046) -3.20.0INS, KCNJ11, GCK, ABCC8
negative regulation of secretion (GO:0051048) -4.440.001INS, KCNJ11, GCK, ABCC8
regulation of transport (GO:0051049) -2.240.02INS, KCNJ11, GCK, ABCC8
cellular response to glucose starvation (GO:0042149) NEW6.290.028INS, GCK
response to estradiol (GO:0032355) NEW4.730.043INS, KCNJ11, ABCC8
glucose homeostasis (GO:0042593) -4.60.001INS, KCNJ11, GCK
negative regulation of insulin secretion (GO:0046676) -5.990.001INS, KCNJ11, ABCC8
regulation of polysaccharide biosynthetic process (GO:0032885) -6.090.012INS, GCK
generation of precursor metabolites and energy (GO:0006091) NEW4.070.0INS, KCNJ11, GCK, ABCC8
regulation of glucan biosynthetic process (GO:0010962) -6.330.008INS, GCK
cellular response to leptin stimulus (GO:0044320) NEW7.530.028INS, GCK
detection of hexose stimulus (GO:0009732) NEW8.630.001INS, GCK
negative regulation of carbohydrate metabolic process (GO:0045912) -5.760.014INS, GCK
detection of carbohydrate stimulus (GO:0009730) NEW8.630.001INS, GCK
positive regulation of cellular carbohydrate metabolic process (GO:0010676) -5.720.026INS, GCK
regulation of cellular localization (GO:0060341) NEW3.030.004INS, KCNJ11, GCK, ABCC8
cellular potassium ion transport (GO:0071804) -4.790.025INS, KCNJ11, ABCC8
potassium ion transmembrane transport (GO:0071805) -4.790.025INS, KCNJ11, ABCC8
cellular response to organonitrogen compound (GO:0071417) -3.870.025INS, KCNJ11, GCK
carbohydrate homeostasis (GO:0033500) -4.60.001INS, KCNJ11, GCK
positive regulation of glycogen metabolic process (GO:0070875) -6.90.003INS, GCK
glucose transport (GO:0015758) -5.80.047INS, GCK
energy reserve metabolic process (GO:0006112) NEW5.440.0INS, KCNJ11, ABCC8, GCK
regulation of polysaccharide metabolic process (GO:0032881) -5.970.017INS, GCK
regulation of glycolytic process (GO:0006110) -6.260.007INS, GCK
regulation of gluconeogenesis (GO:0006111) -6.070.013INS, GCK
positive regulation of carbohydrate metabolic process (GO:0045913) -5.40.033INS, GCK
positive regulation of glycogen biosynthetic process (GO:0045725) -7.020.002INS, GCK
negative regulation of gluconeogenesis (GO:0045721) -7.160.009INS, GCK
negative regulation of epinephrine secretion (GO:0032811) NEW7.650.003INS, GCK
negative regulation of catecholamine secretion (GO:0033604) NEW6.960.013INS, GCK
endocrine pancreas development (GO:0031018) NEW6.360.015INS, GCK
negative regulation of transport (GO:0051051) -3.60.047INS, KCNJ11, GCK, ABCC8
potassium ion transport (GO:0006813) -4.680.04INS, KCNJ11, ABCC8
positive regulation of glucose metabolic process (GO:0010907) -6.150.01INS, GCK
response to leptin (GO:0044321) NEW6.840.036INS, GCK
hexose metabolic process (GO:0019318) -4.640.003INS, KCNJ11, GCK
regulation of insulin secretion (GO:0050796) -4.570.0INS, KCNJ11, GCK, ABCC8
regulation of peptide hormone secretion (GO:0090276) -4.410.0INS, KCNJ11, GCK, ABCC8
regulation of hormone secretion (GO:0046883) -4.180.0INS, KCNJ11, GCK, ABCC8
glucose 6-phosphate metabolic process (GO:0051156) NEW6.680.007INS, GCK
detection of glucose (GO:0051594) NEW8.630.001INS, GCK
negative regulation of cellular carbohydrate metabolic process (GO:0010677) -5.880.009INS, GCK
negative regulation of hormone secretion (GO:0046888) -5.410.0INS, KCNJ11, GCK, ABCC8
cell communication (GO:0007154) -3.040.003INS, KCNJ11, ABCC8, GCK
cellular chemical homeostasis (GO:0055082) -3.40.049INS, KCNJ11, ABCC8, GCK
regulation of glycogen metabolic process (GO:0070873) -6.170.012INS, GCK
regulation of epinephrine secretion (GO:0014060) NEW7.530.004INS, GCK
oxidation-reduction process (GO:0055114) NEW2.910.007INS, KCNJ11, GCK, ABCC8
energy derivation by oxidation of organic compounds (GO:0015980) NEW4.930.001INS, KCNJ11, ABCC8, GCK
regulation of carbohydrate catabolic process (GO:0043470) -5.970.011INS, GCK
regulation of cellular carbohydrate catabolic process (GO:0043471) NEW7.090.011INS, GCK
detection of monosaccharide stimulus (GO:0034287) NEW8.630.001INS, GCK
response to carbohydrate (GO:0009743) -4.620.001INS, KCNJ11, ABCC8, GCK
carbohydrate metabolic process (GO:0005975) -3.260.002INS, KCNJ11, GCK, ABCC8
regulation of glycogen biosynthetic process (GO:0005979) -6.330.008INS, GCK
regulation of peptide secretion (GO:0002791) -4.380.0INS, KCNJ11, GCK, ABCC8
cellular response to nitrogen compound (GO:1901699) -3.790.031INS, KCNJ11, GCK
positive regulation of peptide hormone secretion (GO:0090277) -5.260.046INS, GCK
positive regulation of glycolytic process (GO:0045821) -7.090.002INS, GCK
monosaccharide metabolic process (GO:0005996) -4.570.004INS, KCNJ11, GCK
glucose metabolic process (GO:0006006) -4.940.001INS, KCNJ11, GCK
fructose 2,6-bisphosphate metabolic process (GO:0006003) NEW7.940.003INS, GCK
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.284INS, KCNJ11, ABCC8, GCK
intracellular organelle part (GO:0044446) 0.814INS, KCNJ11, GCK, ABCC8
cytoplasmic part (GO:0044444) 0.824INS, KCNJ11, ABCC8, GCK
cell part (GO:0044464) 0.114INS, KCNJ11, GCK, ABCC8
organelle part (GO:0044422) 0.794INS, KCNJ11, ABCC8, GCK
intracellular organelle (GO:0043229) 0.513INS, KCNJ11, GCK
membrane (GO:0016020) 0.683INS, KCNJ11, ABCC8
membrane-bounded organelle (GO:0043227) 0.473INS, KCNJ11, GCK
intracellular membrane-bounded organelle (GO:0043231) 0.63INS, KCNJ11, GCK
organelle (GO:0043226) 0.43INS, KCNJ11, GCK
potassium channel complex (GO:0034705) 5.322KCNJ11, ABCC8
ion channel complex (GO:0034702) 4.182KCNJ11, ABCC8
cation channel complex (GO:0034703) 4.692KCNJ11, ABCC8
transmembrane transporter complex (GO:1902495) 4.062KCNJ11, ABCC8
intrinsic component of membrane (GO:0031224) 1.132KCNJ11, ABCC8
vesicle (GO:0031982) 1.642INS, GCK
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122INS, GCK
cytoplasmic vesicle (GO:0031410) 2.872INS, GCK
integral component of membrane (GO:0016021) 1.142KCNJ11, ABCC8
mitochondrion (GO:0005739) 2.422KCNJ11, GCK
membrane-bounded vesicle (GO:0031988) 1.712INS, GCK
cytoplasmic vesicle part (GO:0044433) 3.412INS, ABCC8
neuron part (GO:0097458) 2.642KCNJ11, ABCC8
plasma membrane part (GO:0044459) 1.952KCNJ11, ABCC8
sarcolemma (GO:0042383) 5.22KCNJ11, ABCC8
bounding membrane of organelle (GO:0098588) 2.392INS, ABCC8
transporter complex (GO:1990351) 4.042KCNJ11, ABCC8
voltage-gated potassium channel complex (GO:0008076) 5.342KCNJ11, ABCC8
intracellular vesicle (GO:0097708) 2.862INS, GCK
plasma membrane (GO:0005886) 1.392KCNJ11, ABCC8
organelle membrane (GO:0031090) 1.972INS, ABCC8
protein complex (GO:0043234) 1.512KCNJ11, ABCC8
macromolecular complex (GO:0032991) 1.352KCNJ11, ABCC8
cytosol (GO:0005829) 1.682KCNJ11, GCK
plasma membrane protein complex (GO:0098797) 3.552KCNJ11, ABCC8
membrane protein complex (GO:0098796) 2.842KCNJ11, ABCC8
nuclear part (GO:0044428) 1.552KCNJ11, GCK
membrane part (GO:0044425) 0.952KCNJ11, ABCC8

NET-GE enrichment

Term New enriched termICP valueGenes
intercalated disc (GO:0014704) NEW5.930.025KCNJ11, ABCC8
sarcolemma (GO:0042383) -5.20.001INS, KCNJ11, ABCC8
myelin sheath (GO:0043209) NEW4.760.007KCNJ11, ABCC8
leading edge membrane (GO:0031256) NEW4.90.006INS, KCNJ11, ABCC8
cell-cell contact zone (GO:0044291) NEW5.690.043KCNJ11, ABCC8
transporter complex (GO:1990351) -4.040.029INS, KCNJ11, ABCC8
voltage-gated potassium channel complex (GO:0008076) -5.340.006KCNJ11, ABCC8
myofibril (GO:0030016) NEW6.140.018KCNJ11, ABCC8
potassium channel complex (GO:0034705) -5.320.006KCNJ11, ABCC8
ion channel complex (GO:0034702) -4.180.019INS, KCNJ11, ABCC8
cation channel complex (GO:0034703) -4.690.027INS, KCNJ11, ABCC8
contractile fiber (GO:0043292) NEW5.810.036KCNJ11, ABCC8
transmembrane transporter complex (GO:1902495) -4.060.027INS, KCNJ11, ABCC8