Gene table of LIG3 : DNA ligase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with LIG3	OMIM link	Number of associated genes	genes
115000	CARDIAC ARRHYTHMIA	ClinVar	link to OMIM	25	KCNE3, CACNB2, AKAP9, NPPA, KCNE1, SCN4B, CASQ2, KCNJ5, TANGO2, JUP, ANK2, KCNJ2, DSG2, NOS1AP, KCNJ8, LIG3, RYR2, CACNA1C, KCNE2, KCNH2, SCN5A, HCN4, SNTA1, SCN1B, KCNQ1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Base excision repair	hsa03410	7.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
DNA Repair	R-HSA-73894	5.8
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	R-HSA-5649702	10.18
Base Excision Repair	R-HSA-73884	7.85
Resolution of Abasic Sites (AP sites)	R-HSA-73933	7.85
Resolution of AP sites via the single-nucleotide replacement pathway	R-HSA-110381	10.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
ligase activity, forming phosphoric ester bonds	GO:0016886	7.44
zinc ion binding	GO:0008270	2.66
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
transition metal ion binding	GO:0046914	2.48
DNA ligase (ATP) activity	GO:0003910	7.95
nucleotide binding	GO:0000166	1.96
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
ligase activity	GO:0016874	3.72
DNA ligase activity	GO:0003909	7.79
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
binding	GO:0005488	0.18