Gene table of HCN4 : hyperpolarization activated cyclic nucleotide gated potassium channel 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with HCN4	OMIM link	Number of associated genes	genes
PS601144	BRUGADA SYNDROME	ClinVar, OMIM	link to OMIM	9	KCNE3, KCND3, CACNB2, SCN3B, HCN4, CACNA1C, GPD1L, SCN5A, SCN1B
PS608567	SICK SINUS SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	MYH6, SCN5A, HCN4
115000	CARDIAC ARRHYTHMIA	ClinVar	link to OMIM	25	KCNE3, CACNB2, AKAP9, NPPA, KCNE1, SCN4B, CASQ2, KCNJ5, TANGO2, JUP, ANK2, KCNJ2, DSG2, NOS1AP, KCNJ8, LIG3, RYR2, CACNA1C, KCNE2, KCNH2, SCN5A, HCN4, SNTA1, SCN1B, KCNQ1

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Annotation of the gene HCN4

Associated genes in ENSEMBL

ENSG00000138622

Associated proteins - SwissProt Accession ID

Q9Y3Q4

Associated PDB IDs

Cytogenetic Band

15q24.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
cAMP signaling pathway	hsa04024	5.05

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Neuronal System	R-HSA-112316	4.82
HCN channels	R-HSA-1296061	10.98
Potassium Channels	R-HSA-1296071	6.35

Associated GO terms for Molecular function

GO term	GO ID	GO IC
potassium channel activity	GO:0005267	4.94
cation channel activity	GO:0005261	4.04
cyclic nucleotide-gated ion channel activity	GO:0043855	7.34
intracellular cyclic nucleotide activated cation channel activity	GO:0005221	7.34
intracellular cAMP activated cation channel activity	GO:0005222	7.54
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential	GO:1905030	6.74
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
ligand-gated channel activity	GO:0022834	4.8
sodium ion transmembrane transporter activity	GO:0015081	4.83
ligand-gated ion channel activity	GO:0015276	4.8
nucleotide binding	GO:0000166	1.96
transmembrane transporter activity	GO:0022857	2.82
voltage-gated cation channel activity	GO:0022843	4.83
purine nucleotide binding	GO:0017076	2.19
metal ion transmembrane transporter activity	GO:0046873	3.71
identical protein binding	GO:0042802	2.63
cation transmembrane transporter activity	GO:0008324	3.32
sodium channel activity	GO:0005272	6.13
protein binding	GO:0005515	0.46
inorganic cation transmembrane transporter activity	GO:0022890	3.49
transporter activity	GO:0005215	2.57
ion channel activity	GO:0005216	3.71
intracellular ligand-gated ion channel activity	GO:0005217	6.41
small molecule binding	GO:0036094	1.89
substrate-specific transporter activity	GO:0022892	2.72
transmembrane receptor activity	GO:0099600	2.53
passive transmembrane transporter activity	GO:0022803	3.6
substrate-specific transmembrane transporter activity	GO:0022891	2.9
cAMP binding	GO:0030552	6.56
cyclic nucleotide binding	GO:0030551	6.13
substrate-specific channel activity	GO:0022838	3.67
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ion transmembrane transporter activity	GO:0015075	3.04
voltage-gated channel activity	GO:0022832	4.49
monovalent inorganic cation transmembrane transporter activity	GO:0015077	3.87
channel activity	GO:0015267	3.6
adenyl ribonucleotide binding	GO:0032559	2.41
gated channel activity	GO:0022836	3.96
voltage-gated potassium channel activity	GO:0005249	5.24
voltage-gated sodium channel activity	GO:0005248	6.74
purine ribonucleotide binding	GO:0032555	2.2
voltage-gated ion channel activity	GO:0005244	4.49
potassium ion transmembrane transporter activity	GO:0015079	4.77
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32