Disease table of CARDIAC ARRHYTHMIA OMIM ID: 115000

Gene-disease associations table

Gene	Associated with CARDIAC ARRHYTHMIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
KCNE2	ClinVar	HGNC link	21q22.11	3	PS192500, PS608583, 115000
KCNE3	ClinVar	HGNC link	11q13.4	2	PS601144, 115000
KCNE1	ClinVar	HGNC link	21q22.12	5	612347, 115000, 613035, 220400, PS192500
HCN4	ClinVar	HGNC link	15q24.1	3	PS601144, PS608567, 115000
TANGO2	ClinVar	HGNC link	22q11.21	2	115000, 616878
CASQ2	ClinVar	HGNC link	1p13.1	2	115000, PS604772
CACNB2	ClinVar	HGNC link	10p12.33	2	PS601144, 115000
RYR2	ClinVar	HGNC link	1q43	4	115000, PS604772, PS107970, 603829
CACNA1C	ClinVar	HGNC link	12p13.33	4	PS601144, 603829, 115000, PS192500
JUP	ClinVar	HGNC link	17q21.2	4	601214, PS107970, 115000, 603829
LIG3	ClinVar	HGNC link	17q12	1	115000
DSG2	ClinVar	HGNC link	18q12.1	4	115000, PS604772, PS115200, PS107970
SCN4B	ClinVar	HGNC link	11q23.3	4	272120, PS608583, 115000, PS192500
NOS1AP	ClinVar	HGNC link	1q23.3	1	115000
NPPA	ClinVar	HGNC link	1p36.22	3	115000, PS608583, 615745
SNTA1	ClinVar	HGNC link	20q11.21	3	PS192500, 603829, 115000
KCNQ1	ClinVar	HGNC link	11p15.5	6	115000, 272120, PS609620, PS608583, PS192500, 220400
KCNJ2	ClinVar	HGNC link	17q24.3	4	PS609620, PS608583, 115000, PS192500
KCNJ5	ClinVar	HGNC link	11q24.3	3	PS192500, 613677, 115000
KCNH2	ClinVar	HGNC link	7q36.1	6	272120, 603829, PS609620, PS604772, 115000, PS192500
KCNJ8	ClinVar	HGNC link	12p12.1	2	272120, 115000
AKAP9	ClinVar	HGNC link	7q21.2	2	PS192500, 115000
ANK2	ClinVar	HGNC link	4q25	3	PS192500, PS604772, 115000
SCN1B	ClinVar	HGNC link	19q13.11	4	PS601144, PS608583, 115000, PS604233
SCN5A	ClinVar	HGNC link	3p22.2	11	272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
21q22	2	KCNE1, KCNE2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
17q2	2	JUP, KCNJ2
12p1	2	KCNJ8, CACNA1C
11q2	2	SCN4B, KCNJ5
21q2	2	KCNE1, KCNE2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1p	2	NPPA, CASQ2
21q	2	KCNE1, KCNE2
12p	2	KCNJ8, CACNA1C
11q	3	KCNE3, KCNJ5, SCN4B
17q	3	JUP, LIG3, KCNJ2
7q	2	KCNH2, AKAP9
1q	2	NOS1AP, RYR2

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	4	KCNJ5, KCNE3, KCNQ1, SCN4B
12	2	KCNJ8, CACNA1C
21	2	KCNE1, KCNE2
1	4	NPPA, NOS1AP, CASQ2, RYR2
17	3	JUP, LIG3, KCNJ2
7	2	KCNH2, AKAP9

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	KCNH2, HCN4

regulated gene	associated to this disease	# TFs	TFs
HCN4	YES	1	SP1
JUP	YES	1	DNMT3A
NPPA	YES	7	JARID2, GATA4, TBX5, NKX2-2, ANKRD1, FOS, HAND2
KCNH2	YES	1	SP1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
KCNE2	KCNE1	No	1	KCNQ1
KCNE2	KCNQ1	Yes	1	ATP4A
KCNE2	AKAP9	No	1	KCNQ1
KCNE3	TANGO2	No	1	GAPDH
KCNE1	DSG2	No	1	ADRB2
KCNE1	KCNQ1	Yes	0
KCNE1	KCNJ5	No	1	ADRB2
KCNE1	KCNH2	Yes	0
KCNE1	AKAP9	No	1	KCNQ1
TANGO2	JUP	No	1	CAT
TANGO2	NOS1AP	No	1	HSPD1
CASQ2	JUP	No	3	OBSL1, CUL7, CCDC8
CASQ2	LIG3	No	1	CCDC8
CASQ2	DSG2	No	3	OBSL1, CUL7, CCDC8
RYR2	CACNA1C	Yes	3	SRI, RYR2, CALM1
RYR2	SNTA1	Yes	1	RYR2
RYR2	KCNQ1	No	3	PRKAR2A, PRKACA, PPP1CA
RYR2	AKAP9	No	5	CALM1, PRKAR2A, PRKAR2B, PRKACA, PRKACB
RYR2	SCN5A	No	3	SNTA1, CALM1, ALB
CACNA1C	JUP	No	1	COPS5
CACNA1C	SNTA1	No	1	RYR2
CACNA1C	KCNH2	No	1	CUL1
CACNA1C	AKAP9	No	1	CALM1
CACNA1C	SCN5A	No	1	CALM1
JUP	LIG3	No	5	EED, NTRK1, XRCC6, XRCC5, CCDC8
JUP	DSG2	Yes	27	TPM1, DSC2, BMPR1A, MYH9, PKP3, EGFR, LIMA1, PAN2, ABCE1, DBN1, FLNB, OBSL1, DSC1, TMEM17, EED, GOLT1B, PPP1CB, TMOD3, PKP2, CHMP4B, FLOT1, CORO1C, FLNA, CCDC8, SYNPO, MYH10, CUL7
JUP	NOS1AP	No	1	BTRC
JUP	NPPA	No	1	ESR1
JUP	SNTA1	No	1	XRCC6
JUP	KCNQ1	No	1	HSPA4
JUP	KCNH2	No	2	NTRK1, HSPA4
JUP	AKAP9	No	1	DYNLL1
JUP	ANK2	No	2	NTRK1, ABCE1
JUP	SCN5A	No	1	CDK2
LIG3	DSG2	No	3	EED, CBX1, CCDC8
LIG3	NOS1AP	No	1	APP
LIG3	SNTA1	No	1	XRCC6
LIG3	KCNH2	No	2	NTRK1, NDUFS6
LIG3	ANK2	No	1	NTRK1
DSG2	KCNJ5	No	1	ADRB2
DSG2	ANK2	No	1	ABCE1
NOS1AP	SNTA1	No	1	NOS1
NOS1AP	KCNQ1	No	1	AP2M1
SNTA1	SCN5A	Yes	0
KCNQ1	KCNH2	No	3	HSPA4, NEDD4L, KCNE1
KCNQ1	AKAP9	Yes	2	PRKAR2A, PRKACA
KCNQ1	SCN5A	No	1	NEDD4
KCNH2	ANK2	No	1	NTRK1
KCNH2	SCN5A	No	1	CAV3
AKAP9	ANK2	No	1	TNIK
AKAP9	SCN5A	No	1	CALM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
HCN4	NPPA	No	-	1	SRC
CASQ2	RYR2	Yes	activation, binding	2	ASPH, TRDN
CACNB2	RYR2	No	-	27	PPP2R5D, PPP2CA, PPP2R2A, PPP2R2C, PPP2R1B, PRKACA, CAMK2B, CAMK2A, PPP2CB, PPP1CC, PPP2R5C, CAMK2G, PPP2R5A, PPP1CB, PPP2R2B, PRKACG, PPP2R1A, CAMK2D, PPP2R3C, PPP2R3A, PRKX, PPP2R3B, PPP1CA, PRKACB, PPP2R5B, PPP2R5E, CACNA1D
CACNB2	SCN1B	No	-	8	PRKX, CAMK2A, CAMK2B, PRKACG, PRKACB, CAMK2D, PRKACA, CAMK2G
RYR2	NOS1AP	No	-	1	NOS1
RYR2	SCN1B	No	-	8	PRKX, CAMK2A, CAMK2B, PRKACG, PRKACB, CAMK2D, PRKACA, CAMK2G
JUP	DSG2	Yes	activation	1	DSC2
LIG3	DSG2	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
KCNQ1	AKAP9	Yes	KCNQ1 macromolecular complex	8	PRKAR2A, PRKAR2B, PPP1CA, PRKACG, PPP1CB, PPP1CC, PRKACA, PRKACB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CACNA1C	KCNQ1	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
CACNA1C	SCN5A	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3
KCNQ1	SCN5A	No	4	CALM1, CALM2, CALM3, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
KCNE1	KCNQ1	yes, complex	They are in interaction. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	8	CACNA1C, RYR2, SCN5A, KCNQ1, CACNB2, KCNE1, SCN4B, SCN1B
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	5	RYR2, CACNA1C, CACNB2, JUP, DSG2
Oxytocin signaling pathway	hsa04921	5.4	5	KCNJ2, CACNA1C, CACNB2, RYR2, KCNJ5
Circadian entrainment	hsa04713	6.11	4	CACNA1C, RYR2, NOS1AP, KCNJ5
Gastric acid secretion	hsa04971	6.48	3	KCNJ2, KCNQ1, KCNE2
Cardiac muscle contraction	hsa04260	6.34	3	CACNA1C, CACNB2, RYR2
cAMP signaling pathway	hsa04024	5.05	3	CACNA1C, RYR2, HCN4
Cholinergic synapse	hsa04725	5.88	3	KCNJ2, CACNA1C, KCNQ1
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	3	CACNA1C, CACNB2, RYR2
Dilated cardiomyopathy	hsa05414	6.08	3	CACNA1C, CACNB2, RYR2
Pancreatic secretion	hsa04972	6.07	2	RYR2, KCNQ1
Protein digestion and absorption	hsa04974	6.2	2	KCNQ1, KCNE3
cGMP-PKG signaling pathway	hsa04022	5.32	2	CACNA1C, KCNJ8
Calcium signaling pathway	hsa04020	5.22	2	CACNA1C, RYR2
MAPK signaling pathway	hsa04010	4.63	2	CACNA1C, CACNB2
Retrograde endocannabinoid signaling	hsa04723	6.03	2	CACNA1C, KCNJ5
Insulin secretion	hsa04911	6.18	2	CACNA1C, RYR2
Serotonergic synapse	hsa04726	5.84	2	CACNA1C, KCNJ5
Dopaminergic synapse	hsa04728	5.69	2	CACNA1C, KCNJ5

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Gastric acid secretion (hsa04971)	-	6.48	0.003	KCNJ2, CACNA1C, KCNQ1, KCNE2, KCNH2
Cardiovascular diseases	NEW	5.06	0.014	CACNA1C, RYR2, JUP, DSG2, CACNB2
Circulatory system	NEW	4.63	0.0	CACNA1C, AKAP9, RYR2, SCN5A, KCNE1, NPPA, KCNQ1, KCNH2, CACNB2, ANK2, SCN4B, SNTA1, SCN1B
Oxytocin signaling pathway (hsa04921)	-	5.4	0.025	CACNA1C, RYR2, KCNJ5, KCNJ2, CACNB2, NPPA
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)	-	6.32	0.0	RYR2, CACNA1C, CACNB2, JUP, DSG2
Circadian entrainment (hsa04713)	-	6.11	0.009	CACNA1C, AKAP9, RYR2, NOS1AP, KCNJ5
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNQ1, KCNH2, CACNB2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
Environmental adaptation	NEW	5.77	0.023	CACNA1C, AKAP9, RYR2, NOS1AP, KCNJ5

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Neuronal System	R-HSA-112316	4.82	8	AKAP9, HCN4, KCNQ1, KCNH2, KCNJ2, CACNB2, KCNJ5, KCNJ8
Axon guidance	R-HSA-422475	3.93	7	CACNA1C, AKAP9, SCN4B, CACNB2, ANK2, SCN5A, SCN1B
Developmental Biology	R-HSA-1266738	3.48	7	CACNA1C, AKAP9, SCN5A, CACNB2, ANK2, SCN4B, SCN1B
Potassium Channels	R-HSA-1296071	6.35	6	HCN4, KCNQ1, KCNH2, KCNJ2, KCNJ5, KCNJ8
Transmission across Chemical Synapses	R-HSA-112315	5.28	4	AKAP9, KCNJ2, CACNB2, KCNJ5
L1CAM interactions	R-HSA-373760	6.19	4	SCN5A, SCN4B, SCN1B, ANK2
Interaction between L1 and Ankyrins	R-HSA-445095	8.03	4	SCN5A, SCN4B, SCN1B, ANK2
Inwardly rectifying K+ channels	R-HSA-1296065	8.03	3	KCNJ2, KCNJ8, KCNJ5
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	CACNA1C, AKAP9, CACNB2
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	3	KCNJ2, AKAP9, KCNJ5
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	R-HSA-997272	8.34	2	KCNJ2, KCNJ5
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	AKAP9, JUP
Activation of G protein gated Potassium channels	R-HSA-1296041	8.34	2	KCNJ2, KCNJ5
Voltage gated Potassium channels	R-HSA-1296072	7.56	2	KCNH2, KCNQ1
Adrenaline,noradrenaline inhibits insulin secretion	R-HSA-400042	8.18	2	CACNA1C, CACNB2
Ion channel transport	R-HSA-983712	5.34	2	RYR2, CASQ2
GABA B receptor activation	R-HSA-977444	7.7	2	KCNJ2, KCNJ5
Integration of energy metabolism	R-HSA-163685	6.24	2	CACNA1C, CACNB2
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	RYR2, CASQ2
GABA receptor activation	R-HSA-977443	7.2	2	KCNJ2, KCNJ5
Signaling by VEGF	R-HSA-194138	4.66	2	AKAP9, JUP
NCAM1 interactions	R-HSA-419037	7.59	2	CACNA1C, CACNB2
Activation of GABAB receptors	R-HSA-991365	7.7	2	KCNJ2, KCNJ5
Metabolism	R-HSA-1430728	2.34	2	CACNA1C, CACNB2
G protein gated Potassium channels	R-HSA-1296059	8.34	2	KCNJ2, KCNJ5
Stimuli-sensing channels	R-HSA-2672351	6.28	2	RYR2, CASQ2
Regulation of insulin secretion	R-HSA-422356	6.66	2	CACNA1C, CACNB2
Signal Transduction	R-HSA-162582	1.78	2	AKAP9, JUP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Inwardly rectifying K+ channels (R-HSA-1296065)	-	8.03	0.0	KCNJ2, CACNA1C, KCNJ8, KCNJ5, ANK2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (R-HSA-997272)	-	8.34	0.01	KCNJ2, CACNA1C, KCNJ5
Activation of G protein gated Potassium channels (R-HSA-1296041)	-	8.34	0.01	KCNJ2, CACNA1C, KCNJ5
L1CAM interactions (R-HSA-373760)	-	6.19	0.014	SCN5A, SCN4B, SCN1B, ANK2
Potassium Channels (R-HSA-1296071)	-	6.35	0.0	CACNA1C, ANK2, HCN4, KCNQ1, KCNH2, KCNJ2, KCNJ5, KCNJ8
Interaction between L1 and Ankyrins (R-HSA-445095)	-	8.03	0.0	SCN5A, SCN4B, SCN1B, ANK2
Integration of energy metabolism (R-HSA-163685)	-	6.24	0.017	CACNA1C, KCNQ1, CACNB2, KCNH2, ANK2
Activation of GABAB receptors (R-HSA-991365)	-	7.7	0.034	KCNJ2, CACNA1C, KCNJ5
G protein gated Potassium channels (R-HSA-1296059)	-	8.34	0.01	KCNJ2, CACNA1C, KCNJ5
GABA B receptor activation (R-HSA-977444)	-	7.7	0.034	KCNJ2, CACNA1C, KCNJ5
Neuronal System (R-HSA-112316)	-	4.82	0.0	AKAP9, CACNA1C, RYR2, ANK2, HCN4, KCNQ1, KCNH2, KCNJ2, CACNB2, KCNJ5, SNTA1, KCNJ8
Axon guidance (R-HSA-422475)	-	3.93	0.016	CACNA1C, AKAP9, RYR2, SCN5A, NPPA, CACNB2, ANK2, SCN4B, SNTA1, SCN1B
Transmission across Chemical Synapses (R-HSA-112315)	-	5.28	0.03	CACNA1C, AKAP9, KCNJ2, CACNB2, KCNJ5, SNTA1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	23	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
protein binding (GO:0005515)	0.46	23	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	15	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, KCNJ8, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	15	CACNA1C, RYR2, SCN5A, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
substrate-specific transporter activity (GO:0022892)	2.72	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNE1, SCN4B, KCNJ8, SCN1B
cation channel activity (GO:0005261)	4.04	15	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNE3, KCNE1, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, KCNJ8, SCN1B
transporter activity (GO:0005215)	2.57	15	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNE3, KCNE1, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, KCNJ8, SCN1B
ion channel activity (GO:0005216)	3.71	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNE1, SCN4B, KCNJ8, SCN1B
cation transmembrane transporter activity (GO:0008324)	3.32	15	CACNA1C, RYR2, SCN5A, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
ion transmembrane transporter activity (GO:0015075)	3.04	15	CACNA1C, RYR2, KCNE1, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN5A, SCN4B, KCNJ8, SCN1B
transmembrane transporter activity (GO:0022857)	2.82	15	CACNA1C, RYR2, SCN5A, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
channel activity (GO:0015267)	3.6	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
gated channel activity (GO:0022836)	3.96	15	CACNA1C, RYR2, SCN5A, HCN4, KCNH2, KCNE1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
passive transmembrane transporter activity (GO:0022803)	3.6	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
metal ion transmembrane transporter activity (GO:0046873)	3.71	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
substrate-specific channel activity (GO:0022838)	3.67	15	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, KCNJ8, SCN1B
voltage-gated channel activity (GO:0022832)	4.49	14	CACNA1C, SCN5A, HCN4, KCNH2, KCNE1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
voltage-gated ion channel activity (GO:0005244)	4.49	14	CACNA1C, SCN5A, KCNE1, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, KCNJ8, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	12	SCN5A, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
voltage-gated cation channel activity (GO:0022843)	4.83	11	CACNA1C, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, KCNJ8
potassium channel activity (GO:0005267)	4.94	9	KCNE1, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNH2, KCNJ8
enzyme binding (GO:0019899)	2.27	9	RYR2, SCN5A, KCNQ1, NOS1AP, KCNH2, CACNB2, JUP, ANK2, SNTA1
potassium ion transmembrane transporter activity (GO:0015079)	4.77	9	KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
ion channel binding (GO:0044325)	5.02	9	AKAP9, RYR2, SCN4B, KCNQ1, KCNE3, KCNE2, ANK2, SCN5A, SNTA1
voltage-gated potassium channel activity (GO:0005249)	5.24	9	KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
channel regulator activity (GO:0016247)	4.88	8	AKAP9, KCNE1, KCNE3, KCNE2, CACNB2, SCN4B, SNTA1, SCN1B
molecular function regulator (GO:0098772)	2.51	8	AKAP9, KCNE1, KCNE3, KCNE2, CACNB2, SCN4B, SNTA1, SCN1B
ligand-gated ion channel activity (GO:0015276)	4.8	7	RYR2, HCN4, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
molecular transducer activity (GO:0060089)	2.32	7	RYR2, HCN4, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
receptor activity (GO:0004872)	2.32	7	RYR2, HCN4, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
ligand-gated channel activity (GO:0022834)	4.8	7	RYR2, HCN4, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
transmembrane receptor activity (GO:0099600)	2.53	7	RYR2, HCN4, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
identical protein binding (GO:0042802)	2.63	7	RYR2, CASQ2, HCN4, KCNH2, KCNE2, KCNJ2, JUP
protein kinase binding (GO:0019901)	3.44	6	RYR2, SCN5A, KCNQ1, CACNB2, JUP, ANK2
kinase binding (GO:0019900)	3.32	6	RYR2, SCN5A, KCNQ1, CACNB2, JUP, ANK2
cytoskeletal protein binding (GO:0008092)	3.02	6	CACNA1C, SCN5A, CACNB2, ANK2, KCNE1, SNTA1
cation binding (GO:0043169)	1.4	5	CACNA1C, RYR2, CASQ2, LIG3, DSG2
organic cyclic compound binding (GO:0097159)	1.05	5	AKAP9, RYR2, KCNJ8, HCN4, LIG3
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008)	7.79	5	KCNJ2, KCNH2, KCNE1, KCNE2, KCNQ1
ion binding (GO:0043167)	1.36	5	CACNA1C, RYR2, CASQ2, LIG3, DSG2
calmodulin binding (GO:0005516)	4.55	5	CACNA1C, KCNQ1, RYR2, SCN5A, SNTA1
metal ion binding (GO:0046872)	1.41	5	CACNA1C, RYR2, CASQ2, LIG3, DSG2
inward rectifier potassium channel activity (GO:0005242)	6.65	5	KCNJ2, KCNH2, KCNJ8, KCNJ5, KCNE2
sodium channel activity (GO:0005272)	6.13	4	SCN5A, SCN4B, HCN4, SCN1B
sodium ion transmembrane transporter activity (GO:0015081)	4.83	4	SCN5A, SCN4B, HCN4, SCN1B
potassium channel regulator activity (GO:0015459)	5.93	4	AKAP9, KCNE1, KCNE3, KCNE2
heterocyclic compound binding (GO:1901363)	1.06	4	AKAP9, KCNJ8, HCN4, LIG3
protein domain specific binding (GO:0019904)	3.32	4	KCNH2, CACNB2, SCN5A, SNTA1
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282)	8.35	4	KCNQ1, KCNE1, KCNE2, KCNH2
voltage-gated sodium channel activity (GO:0005248)	6.74	4	SCN5A, SCN4B, HCN4, SCN1B
delayed rectifier potassium channel activity (GO:0005251)	6.15	4	KCNQ1, KCNH2, KCNE1, KCNE2
protein dimerization activity (GO:0046983)	2.72	4	KCNH2, JUP, CASQ2, KCNE2
structural molecule activity (GO:0005198)	3.1	4	AKAP9, SNTA1, JUP, ANK2
voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1905030)	6.74	4	SCN5A, SCN4B, HCN4, SCN1B
protein homodimerization activity (GO:0042803)	3.16	4	CASQ2, JUP, KCNH2, KCNE2
calcium channel activity (GO:0005262)	5.03	3	CACNA1C, RYR2, CACNB2
protein kinase A regulatory subunit binding (GO:0034237)	6.97	3	AKAP9, RYR2, KCNQ1
signal transducer activity (GO:0004871)	2.28	3	JUP, KCNH2, RYR2
divalent inorganic cation transmembrane transporter activity (GO:0072509)	4.62	3	CACNA1C, CACNB2, RYR2
nucleoside phosphate binding (GO:1901265)	1.96	3	KCNJ8, LIG3, HCN4
calcium ion transmembrane transporter activity (GO:0015085)	4.89	3	CACNA1C, CACNB2, RYR2
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	8.13	3	SCN5A, SCN4B, SCN1B
nucleotide binding (GO:0000166)	1.96	3	KCNJ8, LIG3, HCN4
calcium ion binding (GO:0005509)	3.17	3	RYR2, CASQ2, DSG2
purine nucleotide binding (GO:0017076)	2.19	3	KCNJ8, LIG3, HCN4
protein kinase A binding (GO:0051018)	6.02	3	AKAP9, RYR2, KCNQ1
small molecule binding (GO:0036094)	1.89	3	KCNJ8, LIG3, HCN4
catalytic activity (GO:0003824)	1.05	3	AKAP9, KCNH2, LIG3
nitric-oxide synthase binding (GO:0050998)	6.91	3	SNTA1, SCN5A, NOS1AP
adenyl nucleotide binding (GO:0030554)	2.4	3	KCNJ8, LIG3, HCN4
carbohydrate derivative binding (GO:0097367)	2.03	3	KCNJ8, LIG3, HCN4
sodium channel regulator activity (GO:0017080)	6.3	3	SNTA1, SCN4B, SCN1B
adenyl ribonucleotide binding (GO:0032559)	2.41	3	KCNJ8, LIG3, HCN4
purine ribonucleotide binding (GO:0032555)	2.2	3	KCNJ8, LIG3, HCN4
receptor binding (GO:0005102)	2.43	3	AKAP9, KCNJ8, NPPA
scaffold protein binding (GO:0097110)	5.93	3	KCNQ1, KCNH2, SCN5A
ribonucleotide binding (GO:0032553)	2.19	3	KCNJ8, LIG3, HCN4
signaling receptor activity (GO:0038023)	2.49	2	RYR2, KCNH2
protein binding involved in cell adhesion (GO:0098631)	6.91	2	JUP, DSG2
protein binding involved in cell-cell adhesion (GO:0098632)	7.34	2	JUP, DSG2
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	KCNJ8, LIG3
high voltage-gated calcium channel activity (GO:0008331)	7.34	2	CACNA1C, CACNB2
G-protein activated inward rectifier potassium channel activity (GO:0015467)	7.44	2	KCNJ2, KCNJ5
protein kinase A catalytic subunit binding (GO:0034236)	7.03	2	RYR2, KCNQ1
nucleic acid binding (GO:0003676)	1.44	2	AKAP9, LIG3
DNA binding (GO:0003677)	1.92	2	AKAP9, LIG3
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	KCNH2, SCN5A
voltage-gated sodium channel activity involved in Purkinje myocyte action potential (GO:0086062)	9.05	2	SCN5A, SCN1B
purine nucleoside binding (GO:0001883)	2.22	2	KCNJ8, LIG3
nucleoside binding (GO:0001882)	2.21	2	KCNJ8, LIG3
phosphatidylinositol bisphosphate binding (GO:1902936)	5.79	2	KCNJ2, KCNQ1
voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007)	8.13	2	CACNA1C, CACNB2
phospholipid binding (GO:0005543)	3.91	2	KCNJ2, KCNQ1
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	5.81	2	KCNJ2, KCNQ1
actin binding (GO:0003779)	3.74	2	CACNB2, SNTA1
transferase activity (GO:0016740)	1.95	2	AKAP9, KCNH2
ribonucleoside binding (GO:0032549)	2.22	2	KCNJ8, LIG3
protein binding involved in heterotypic cell-cell adhesion (GO:0086080)	7.54	2	JUP, DSG2
ATP binding (GO:0005524)	2.43	2	KCNJ8, LIG3
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083)	7.95	2	JUP, DSG2
intracellular ligand-gated ion channel activity (GO:0005217)	6.41	2	RYR2, HCN4
ATPase binding (GO:0051117)	5.41	2	SNTA1, ANK2
kinase activity (GO:0016301)	2.93	2	AKAP9, KCNH2
lipid binding (GO:0008289)	3.26	2	KCNJ2, KCNQ1
voltage-gated calcium channel activity involved in AV node cell action potential (GO:0086056)	8.64	2	CACNA1C, CACNB2
protein phosphatase binding (GO:0019903)	4.93	2	JUP, KCNQ1
phosphatase binding (GO:0019902)	4.63	2	JUP, KCNQ1
phosphatidylinositol phosphate binding (GO:1901981)	5.05	2	KCNJ2, KCNQ1
cell adhesion molecule binding (GO:0050839)	4.5	2	JUP, DSG2
ubiquitin protein ligase binding (GO:0031625)	4.17	2	KCNH2, SCN5A
phosphatidylinositol binding (GO:0035091)	4.47	2	KCNJ2, KCNQ1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	AKAP9, KCNH2
voltage-gated calcium channel activity (GO:0005245)	6.0	2	CACNA1C, CACNB2
purine ribonucleoside binding (GO:0032550)	2.22	2	KCNJ8, LIG3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
potassium channel activity (GO:0005267)	-	4.94	0.0	CACNA1C, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNH2, KCNJ8
cation channel activity (GO:0005261)	-	4.04	0.0	CACNA1C, AKAP9, RYR2, SCN4B, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN5A, SNTA1, KCNJ8, SCN1B
enzyme binding (GO:0019899)	-	2.27	0.048	CACNA1C, AKAP9, RYR2, CASQ2, NPPA, KCNQ1, NOS1AP, KCNH2, KCNJ2, JUP, ANK2, SCN5A, SNTA1, SCN1B
protein kinase A catalytic subunit binding (GO:0034236)	-	7.03	0.018	RYR2, KCNQ1
protein kinase A regulatory subunit binding (GO:0034237)	-	6.97	0.012	RYR2, KCNQ1
sodium channel activity (GO:0005272)	-	6.13	0.0	SCN5A, SCN4B, HCN4, SCN1B
ion channel binding (GO:0044325)	-	5.02	0.0	AKAP9, CACNA1C, RYR2, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, ANK2, CASQ2, SNTA1
ankyrin binding (GO:0030506)	NEW	6.74	0.009	RYR2, SCN5A, ANK2
voltage-gated sodium channel activity involved in cardiac muscle cell action potential (GO:0086006)	-	8.13	0.0	SCN5A, SCN4B, SCN1B
ligand-gated channel activity (GO:0022834)	-	4.8	0.0	AKAP9, RYR2, ANK2, HCN4, KCNH2, KCNJ2, KCNJ5, KCNJ8
sodium ion transmembrane transporter activity (GO:0015081)	-	4.83	0.009	SCN5A, SCN4B, SCN1B, ANK2, HCN4
sodium channel inhibitor activity (GO:0019871)	NEW	8.13	0.014	SCN5A, SCN1B
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	-	3.87	0.0	SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, SNTA1, KCNJ8, SCN1B
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization (GO:0086008)	-	7.79	0.0	KCNJ2, KCNQ1, KCNH2, KCNE2
ligand-gated ion channel activity (GO:0015276)	-	4.8	0.0	AKAP9, RYR2, ANK2, HCN4, KCNH2, KCNJ2, KCNJ5, KCNJ8
voltage-gated cation channel activity (GO:0022843)	-	4.83	0.0	CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization (GO:1902282)	-	8.35	0.0	KCNH2, KCNQ1, KCNE2
channel inhibitor activity (GO:0016248)	NEW	6.13	0.001	KCNH2, RYR2, SCN5A, SCN1B
channel regulator activity (GO:0016247)	-	4.88	0.0	RYR2, SCN5A, KCNE1, KCNE3, KCNQ1, KCNE2, ANK2, KCNH2, SCN4B, SCN1B
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.0	CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
potassium channel regulator activity (GO:0015459)	-	5.93	0.0	KCNE1, KCNE3, KCNQ1, KCNE2, ANK2, KCNH2
identical protein binding (GO:0042802)	-	2.63	0.007	RYR2, CASQ2, HCN4, KCNH2, KCNQ1, KCNE2, KCNJ2, JUP
gated channel activity (GO:0022836)	-	3.96	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
intracellular ligand-gated ion channel activity (GO:0005217)	-	6.41	0.007	CACNA1C, RYR2, HCN4
voltage-gated potassium channel activity (GO:0005249)	-	5.24	0.0	ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNH2, KCNJ8
nitric-oxide synthase binding (GO:0050998)	-	6.91	0.0	SNTA1, SCN5A, NOS1AP
transporter activity (GO:0005215)	-	2.57	0.0	CACNA1C, AKAP9, RYR2, SCN4B, ANK2, HCN4, KCNQ1, KCNH2, CACNB2, KCNE2, KCNJ2, JUP, KCNE3, NPPA, KCNJ5, SCN5A, SNTA1, KCNJ8, SCN1B
ion channel activity (GO:0005216)	-	3.71	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
protein kinase binding (GO:0019901)	-	3.44	0.037	KCNQ1, RYR2, SCN5A, JUP, ANK2
substrate-specific transporter activity (GO:0022892)	-	2.72	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
ion channel inhibitor activity (GO:0008200)	NEW	6.15	0.001	KCNH2, RYR2, SCN5A, SCN1B
substrate-specific transmembrane transporter activity (GO:0022891)	-	2.9	0.0	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, KCNJ8, SCN1B
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.0	CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
substrate-specific channel activity (GO:0022838)	-	3.67	0.0	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, KCNJ8, SCN1B
ATPase binding (GO:0051117)	-	5.41	0.004	RYR2, SCN5A, SNTA1, ANK2
cytoskeletal protein binding (GO:0008092)	-	3.02	0.0	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, NPPA, KCNH2, NOS1AP, KCNQ1, TANGO2, ANK2, KCNE1, SNTA1, SCN1B
ion transmembrane transporter activity (GO:0015075)	-	3.04	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
voltage-gated channel activity (GO:0022832)	-	4.49	0.0	CACNA1C, AKAP9, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
transmembrane transporter activity (GO:0022857)	-	2.82	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNH2, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
channel activity (GO:0015267)	-	3.6	0.0	CACNA1C, AKAP9, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
scaffold protein binding (GO:0097110)	-	5.93	0.044	KCNQ1, RYR2, SCN5A
calmodulin binding (GO:0005516)	-	4.55	0.0	CACNA1C, RYR2, SCN5A, KCNQ1, ANK2, SNTA1
protein binding (GO:0005515)	-	0.46	0.008	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, LIG3, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, NOS1AP
voltage-gated sodium channel activity (GO:0005248)	-	6.74	0.0	SCN5A, SCN4B, HCN4, SCN1B
sodium channel regulator activity (GO:0017080)	-	6.3	0.016	SCN5A, SCN4B, SCN1B
voltage-gated calcium channel activity (GO:0005245)	-	6.0	0.03	CACNA1C, RYR2, CACNB2
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.0	CACNA1C, AKAP9, RYR2, SCN4B, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN5A, SNTA1, KCNJ8, SCN1B
potassium ion transmembrane transporter activity (GO:0015079)	-	4.77	0.0	CACNA1C, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNH2, KCNJ8
inward rectifier potassium channel activity (GO:0005242)	-	6.65	0.0	KCNJ2, KCNH2, KCNJ8, KCNJ5, ANK2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
biological regulation (GO:0065007)	0.39	24	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
regulation of biological process (GO:0050789)	0.45	24	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
regulation of localization (GO:0032879)	1.94	23	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, KCNQ1, DSG2, KCNJ2, SNTA1
regulation of transport (GO:0051049)	2.24	22	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN4B, KCNJ8, SCN1B, AKAP9, KCNQ1, KCNJ2, SNTA1
regulation of biological quality (GO:0065008)	1.68	22	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN4B, KCNJ8, SCN1B, AKAP9, KCNQ1, DSG2, KCNJ2, SNTA1
single-organism process (GO:0044699)	0.48	22	CACNA1C, KCNE1, ANK2, KCNE3, CASQ2, SCN5A, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, NPPA, SCN4B, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2
regulation of membrane potential (GO:0042391)	3.89	21	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, NPPA, HCN4, KCNE3, KCNE1, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNQ1, SNTA1, NOS1AP, SCN1B
cellular process (GO:0009987)	0.26	21	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, HCN4, NPPA, KCNE3, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, LIG3, DSG2, KCNJ5, KCNH2, KCNE1, KCNJ8, SCN1B
single-organism cellular process (GO:0044763)	0.65	21	CACNA1C, AKAP9, RYR2, SCN5A, KCNE1, ANK2, HCN4, NPPA, KCNE3, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, LIG3, DSG2, KCNJ5, KCNQ1, KCNJ8, SCN1B
regulation of ion transport (GO:0043269)	3.4	21	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, NOS1AP, CASQ2, KCNE3, KCNE2, KCNQ1, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, KCNJ2, SCN1B
regulation of ion transmembrane transport (GO:0034765)	3.77	21	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE1, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, KCNJ8, NOS1AP, SCN1B
regulation of transmembrane transport (GO:0034762)	3.74	21	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, NOS1AP, CASQ2, KCNE3, KCNE2, KCNQ1, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, KCNJ2, SCN1B
multicellular organismal process (GO:0032501)	1.45	20	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, NPPA, HCN4, KCNQ1, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, SCN4B, SNTA1, KCNJ8, SCN1B
regulation of system process (GO:0044057)	3.53	20	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, DSG2, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, SCN1B, ANK2, SCN4B, SNTA1, NPPA, CASQ2
regulation of heart contraction (GO:0008016)	4.35	20	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, NPPA, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, CASQ2, SNTA1, SCN4B, SCN1B
regulation of cellular process (GO:0050794)	0.5	20	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, LIG3, HCN4, NPPA, KCNH2, NOS1AP, KCNE3, KCNE2, KCNQ1, JUP, DSG2, ANK2, CASQ2, SNTA1, KCNJ2, SCN1B
regulation of heart rate (GO:0002027)	5.29	20	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of blood circulation (GO:1903522)	4.05	20	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of multicellular organismal process (GO:0051239)	1.87	20	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, DSG2, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, SCN1B, ANK2, SCN4B, SNTA1, NPPA, CASQ2
establishment of localization (GO:0051234)	1.48	19	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNQ1, CACNB2, KCNJ5, SCN4B, KCNJ8, KCNJ2, SCN1B
localization (GO:0051179)	1.4	19	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
regulation of metal ion transport (GO:0010959)	3.94	18	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, NPPA, KCNH2, KCNE1, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2, KCNQ1, SNTA1, NOS1AP, SCN1B
transport (GO:0006810)	1.51	18	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
regulation of cation transmembrane transport (GO:1904062)	4.4	18	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, KCNJ2, KCNH2, NOS1AP, KCNE3, KCNE2, KCNQ1, CACNB2, SCN1B, ANK2, SCN4B, SNTA1, NPPA, CASQ2
positive regulation of biological process (GO:0048518)	1.2	17	AKAP9, RYR2, CASQ2, NPPA, KCNQ1, KCNE1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, KCNE3, ANK2, SCN5A, SCN4B, NOS1AP, SCN1B
single organism signaling (GO:0044700)	3.25	17	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, HCN4, KCNH2, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SCN4B, SCN1B
response to stimulus (GO:0050896)	1.22	17	AKAP9, RYR2, SCN5A, CASQ2, LIG3, HCN4, NPPA, KCNH2, KCNQ1, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, KCNJ8, SCN1B
signaling (GO:0023052)	3.25	17	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, HCN4, KCNQ1, KCNE1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, SCN4B, SCN1B
ion transport (GO:0006811)	2.66	17	CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNE3, KCNE1, KCNQ1, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, KCNJ8, SCN1B
single-multicellular organism process (GO:0044707)	1.78	16	CACNA1C, AKAP9, RYR2, SCN5A, HCN4, KCNH2, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SCN4B, SCN1B
positive regulation of transport (GO:0051050)	2.9	16	AKAP9, KCNJ2, RYR2, SCN5A, KCNE1, NPPA, KCNH2, NOS1AP, KCNE3, JUP, KCNE2, KCNQ1, CACNB2, ANK2, SCN4B, SCN1B
cation transport (GO:0006812)	3.11	16	CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
ion transmembrane transport (GO:0034220)	3.08	16	CACNA1C, RYR2, SCN5A, CASQ2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
metal ion transport (GO:0030001)	3.36	16	CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNE3, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
transmembrane transport (GO:0055085)	2.72	16	CACNA1C, RYR2, SCN5A, HCN4, KCNE3, KCNE1, CASQ2, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
multicellular organismal signaling (GO:0035637)	5.36	15	CACNA1C, AKAP9, SCN5A, HCN4, KCNQ1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SCN4B, SCN1B
cardiac conduction (GO:0061337)	5.54	15	CACNA1C, AKAP9, KCNE1, HCN4, KCNQ1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, SCN5A, SCN4B, SCN1B
regulation of membrane repolarization (GO:0060306)	6.4	15	AKAP9, CASQ2, NPPA, KCNQ1, KCNE1, KCNH2, KCNE3, KCNE2, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B, NOS1AP, SCN1B
positive regulation of ion transport (GO:0043270)	4.36	15	AKAP9, RYR2, SCN5A, KCNE1, NPPA, KCNH2, NOS1AP, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2, KCNQ1, SCN4B, SCN1B
regulation of heart rate by cardiac conduction (GO:0086091)	6.33	15	CACNA1C, AKAP9, SCN5A, SCN4B, HCN4, KCNQ1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SCN1B
inorganic cation transmembrane transport (GO:0098662)	3.55	15	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNE3, KCNE1, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, KCNJ8, SCN1B
inorganic ion transmembrane transport (GO:0098660)	3.38	15	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
response to chemical (GO:0042221)	1.98	15	AKAP9, RYR2, SCN5A, KCNE1, NPPA, HCN4, KCNQ1, KCNH2, KCNE2, JUP, DSG2, ANK2, CASQ2, KCNJ8, SCN1B
cation transmembrane transport (GO:0098655)	3.43	15	CACNA1C, RYR2, SCN5A, KCNE1, HCN4, KCNE3, KCNQ1, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, KCNJ8, SCN1B
regulation of molecular function (GO:0065009)	1.78	14	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNE3, JUP, KCNE2, CACNB2, ANK2, CASQ2, SCN4B, SCN1B
system process (GO:0003008)	2.3	14	RYR2, KCNE1, HCN4, KCNQ1, CASQ2, KCNH2, KCNJ2, CACNB2, NPPA, SCN5A, SNTA1, SCN4B, KCNJ8, SCN1B
positive regulation of cellular process (GO:0048522)	1.3	14	AKAP9, RYR2, SCN5A, CASQ2, NPPA, KCNH2, NOS1AP, KCNQ1, KCNE2, KCNJ2, JUP, ANK2, KCNE1, SCN1B
cellular response to stimulus (GO:0051716)	1.97	13	AKAP9, RYR2, SCN5A, CASQ2, LIG3, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, NPPA, KCNE1
cardiac muscle cell action potential (GO:0086001)	6.33	13	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, ANK2, KCNE1, SNTA1, SCN1B
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	13	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2, CASQ2, SCN4B, SCN1B
regulation of transmembrane transporter activity (GO:0022898)	4.52	13	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2, CASQ2, SCN4B, SCN1B
regulation of transporter activity (GO:0032409)	4.45	13	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2, CASQ2, SCN4B, SCN1B
action potential (GO:0001508)	5.42	13	CACNA1C, RYR2, SCN5A, HCN4, KCNH2, KCNQ1, KCNE2, KCNJ2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
single-organism localization (GO:1902578)	2.09	13	CACNA1C, RYR2, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, JUP, KCNJ5, KCNQ1, KCNJ8
cardiac muscle cell action potential involved in contraction (GO:0086002)	6.47	12	CACNA1C, RYR2, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of muscle contraction (GO:0006937)	4.75	12	CACNA1C, RYR2, CASQ2, NPPA, HCN4, NOS1AP, KCNQ1, DSG2, KCNJ2, JUP, ANK2, SCN5A
regulation of striated muscle contraction (GO:0006942)	5.38	12	CACNA1C, RYR2, CASQ2, NPPA, HCN4, NOS1AP, KCNQ1, DSG2, KCNJ2, JUP, ANK2, SCN5A
positive regulation of cation transmembrane transport (GO:1904064)	5.17	12	AKAP9, RYR2, KCNE1, NPPA, KCNH2, NOS1AP, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2, KCNQ1
regulation of cardiac muscle contraction (GO:0055117)	5.57	12	CACNA1C, RYR2, CASQ2, NPPA, HCN4, NOS1AP, KCNQ1, DSG2, KCNJ2, JUP, ANK2, SCN5A
single-organism transport (GO:0044765)	2.18	12	CACNA1C, RYR2, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
regulation of cardiac muscle cell membrane repolarization (GO:0099623)	6.68	12	AKAP9, KCNE1, NPPA, KCNQ1, NOS1AP, KCNH2, KCNE2, ANK2, SCN5A, SNTA1, SCN4B, SCN1B
regulation of muscle system process (GO:0090257)	4.51	12	CACNA1C, RYR2, CASQ2, NPPA, HCN4, NOS1AP, KCNQ1, DSG2, KCNJ2, JUP, ANK2, SCN5A
positive regulation of transmembrane transport (GO:0034764)	4.99	12	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2
positive regulation of ion transmembrane transport (GO:0034767)	5.05	12	AKAP9, RYR2, KCNE1, NPPA, KCNQ1, NOS1AP, KCNH2, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2
monovalent inorganic cation transport (GO:0015672)	3.74	12	SCN5A, KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
regulation of potassium ion transmembrane transport (GO:1901379)	5.62	11	AKAP9, KCNJ2, KCNE1, NPPA, KCNH2, NOS1AP, KCNE3, KCNE2, KCNQ1, ANK2, CASQ2
regulation of potassium ion transport (GO:0043266)	5.31	11	AKAP9, CASQ2, KCNE1, NPPA, KCNH2, NOS1AP, KCNE3, KCNE2, KCNJ2, ANK2, KCNQ1
muscle system process (GO:0003012)	4.18	11	RYR2, CASQ2, HCN4, KCNQ1, KCNH2, KCNJ2, NPPA, SCN5A, SNTA1, SCN4B, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	6.84	11	AKAP9, SCN5A, KCNQ1, NOS1AP, KCNH2, KCNE2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
response to organic substance (GO:0010033)	2.2	11	AKAP9, RYR2, CASQ2, NPPA, HCN4, KCNQ1, DSG2, JUP, ANK2, KCNE1, KCNJ8
developmental process (GO:0032502)	1.36	10	CACNA1C, RYR2, SCN5A, NPPA, KCNQ1, KCNE2, JUP, DSG2, ANK2, KCNJ8
negative regulation of biological process (GO:0048519)	1.33	10	RYR2, KCNE1, LIG3, KCNH2, KCNE3, KCNE2, NPPA, KCNQ1, SNTA1, CASQ2
cellular response to chemical stimulus (GO:0070887)	2.57	10	AKAP9, RYR2, SCN5A, CASQ2, HCN4, KCNH2, KCNQ1, KCNE2, JUP, KCNE1
negative regulation of cellular process (GO:0048523)	1.41	10	RYR2, KCNE1, LIG3, KCNH2, KCNE3, KCNE2, NPPA, KCNQ1, SNTA1, CASQ2
response to oxygen-containing compound (GO:1901700)	2.57	9	AKAP9, RYR2, KCNE1, HCN4, KCNQ1, DSG2, JUP, NPPA, KCNJ8
response to endogenous stimulus (GO:0009719)	2.79	9	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, DSG2, JUP, NPPA, KCNE1
regulation of calcium ion transport (GO:0051924)	4.38	9	CACNA1C, RYR2, CASQ2, NPPA, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2
regulation of metabolic process (GO:0019222)	1.02	9	AKAP9, RYR2, LIG3, NOS1AP, KCNQ1, KCNE2, JUP, ANK2, SNTA1
cellular potassium ion transport (GO:0071804)	4.79	9	KCNE1, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNJ8
potassium ion transmembrane transport (GO:0071805)	4.79	9	KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
potassium ion transport (GO:0006813)	4.68	9	KCNE1, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
response to nitrogen compound (GO:1901698)	3.12	9	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, NPPA, KCNE1, KCNJ8
anatomical structure development (GO:0048856)	1.58	9	CACNA1C, RYR2, SCN5A, KCNQ1, KCNE2, JUP, DSG2, ANK2, KCNJ8
muscle contraction (GO:0006936)	4.37	9	RYR2, SCN5A, SCN4B, HCN4, KCNH2, KCNQ1, CASQ2, SNTA1, SCN1B
regulation of potassium ion transmembrane transporter activity (GO:1901016)	6.02	9	AKAP9, KCNE1, NPPA, KCNQ1, NOS1AP, KCNE3, KCNE2, ANK2, CASQ2
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	9	CACNA1C, RYR2, CASQ2, NPPA, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2
regulation of macromolecule metabolic process (GO:0060255)	1.08	9	AKAP9, RYR2, LIG3, NOS1AP, KCNQ1, KCNE2, JUP, ANK2, SNTA1
positive regulation of molecular function (GO:0044093)	2.23	9	AKAP9, RYR2, NPPA, NOS1AP, KCNE3, CACNB2, KCNE2, JUP, ANK2
regulation of cation channel activity (GO:2001257)	5.27	9	KCNE1, NPPA, KCNE3, NOS1AP, KCNQ1, KCNE2, CACNB2, ANK2, CASQ2
response to organic cyclic compound (GO:0014070)	3.07	9	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, DSG2, JUP, KCNE1, KCNJ8
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	8	AKAP9, RYR2, NPPA, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2
ventricular cardiac muscle cell action potential (GO:0086005)	7.02	8	RYR2, KCNE1, KCNH2, KCNQ1, KCNE2, ANK2, SCN5A, SNTA1
regulation of cellular component movement (GO:0051270)	3.08	8	CACNA1C, RYR2, SCN5A, NOS1AP, DSG2, KCNJ2, JUP, ANK2
positive regulation of transporter activity (GO:0032411)	5.44	8	AKAP9, RYR2, NPPA, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2
regulation of actin filament-based movement (GO:1903115)	6.33	8	CACNA1C, RYR2, SCN5A, NOS1AP, DSG2, KCNJ2, JUP, ANK2
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	8	RYR2, CASQ2, NPPA, NOS1AP, KCNE3, KCNE2, CACNB2, ANK2
response to organonitrogen compound (GO:0010243)	3.2	8	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, NPPA, KCNE1
regulation of actin filament-based process (GO:0032970)	3.97	8	CACNA1C, RYR2, SCN5A, NOS1AP, DSG2, KCNJ2, JUP, ANK2
cellular component organization (GO:0016043)	1.24	8	AKAP9, CASQ2, LIG3, JUP, DSG2, KCNJ2, CACNB2, ANK2
regulation of cardiac muscle cell contraction (GO:0086004)	6.51	8	CACNA1C, RYR2, SCN5A, NOS1AP, DSG2, KCNJ2, JUP, ANK2
single-organism developmental process (GO:0044767)	1.49	8	CACNA1C, RYR2, SCN5A, NPPA, KCNQ1, KCNE2, ANK2, KCNJ8
membrane depolarization (GO:0051899)	5.62	8	CACNA1C, SCN4B, KCNH2, KCNJ2, CACNB2, ANK2, SCN5A, SCN1B
signal transduction (GO:0007165)	1.28	8	CACNA1C, AKAP9, RYR2, CASQ2, NPPA, KCNH2, JUP, ANK2
regulation of action potential (GO:0098900)	6.07	8	CACNA1C, RYR2, SCN5A, NOS1AP, DSG2, KCNJ2, JUP, ANK2
regulation of signaling (GO:0023051)	1.72	8	CACNA1C, RYR2, CASQ2, NPPA, NOS1AP, KCNE2, JUP, ANK2
cell communication (GO:0007154)	3.04	8	CACNA1C, AKAP9, RYR2, CASQ2, CACNB2, ANK2, SCN5A, SCN1B
membrane depolarization during action potential (GO:0086010)	6.07	8	CACNA1C, SCN4B, KCNH2, KCNJ2, CACNB2, ANK2, SCN5A, SCN1B
positive regulation of potassium ion transmembrane transport (GO:1901381)	6.43	8	AKAP9, KCNE1, NPPA, KCNQ1, NOS1AP, KCNH2, KCNJ2, ANK2
cellular component organization or biogenesis (GO:0071840)	1.22	8	AKAP9, CASQ2, LIG3, JUP, DSG2, KCNJ2, CACNB2, ANK2
positive regulation of potassium ion transport (GO:0043268)	6.09	8	AKAP9, KCNE1, NPPA, KCNQ1, NOS1AP, KCNH2, KCNJ2, ANK2
cellular response to endogenous stimulus (GO:0071495)	3.33	7	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, KCNE1
regulation of primary metabolic process (GO:0080090)	1.08	7	AKAP9, RYR2, LIG3, NOS1AP, KCNE2, JUP, SNTA1
cellular response to organic cyclic compound (GO:0071407)	3.93	7	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, KCNE1
cellular response to organonitrogen compound (GO:0071417)	3.87	7	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, KCNE1
cellular response to nitrogen compound (GO:1901699)	3.79	7	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, KCNE1
regulation of cellular metabolic process (GO:0031323)	1.07	7	AKAP9, RYR2, LIG3, NOS1AP, KCNE2, JUP, SNTA1
regulation of homeostatic process (GO:0032844)	3.65	7	CACNA1C, RYR2, CASQ2, HCN4, ANK2, SCN5A, SCN1B
striated muscle contraction (GO:0006941)	5.37	7	RYR2, CASQ2, KCNH2, KCNQ1, SCN5A, SCN4B, SCN1B
cellular response to organic substance (GO:0071310)	2.78	7	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, JUP, KCNE1
regulation of ion homeostasis (GO:2000021)	4.44	7	CACNA1C, RYR2, CASQ2, HCN4, ANK2, SCN5A, SCN1B
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	7.09	7	CACNA1C, SCN5A, KCNJ2, CACNB2, ANK2, SCN4B, SCN1B
regulation of cell communication (GO:0010646)	1.73	7	CACNA1C, RYR2, CASQ2, NOS1AP, KCNE2, JUP, ANK2
cardiac muscle contraction (GO:0060048)	5.88	7	RYR2, SCN5A, CASQ2, KCNH2, KCNQ1, SCN4B, SCN1B
cellular response to oxygen-containing compound (GO:1901701)	3.22	6	AKAP9, RYR2, KCNE1, HCN4, KCNQ1, JUP
negative regulation of ion transmembrane transport (GO:0034766)	5.47	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
primary metabolic process (GO:0044238)	0.69	6	AKAP9, KCNE1, LIG3, KCNQ1, KCNH2, NPPA
regulation of cellular localization (GO:0060341)	3.03	6	CACNA1C, RYR2, CASQ2, JUP, ANK2, KCNE1
negative regulation of transport (GO:0051051)	3.6	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
organic substance metabolic process (GO:0071704)	0.63	6	AKAP9, KCNE1, LIG3, KCNQ1, KCNH2, NPPA
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	RYR2, SCN5A, NOS1AP, KCNQ1, NPPA, SCN1B
regulation of cardiac muscle cell action potential (GO:0098901)	6.78	6	CACNA1C, RYR2, NOS1AP, DSG2, JUP, ANK2
negative regulation of cation transmembrane transport (GO:1904063)	5.65	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
cellular metabolic process (GO:0044237)	0.69	6	AKAP9, KCNE1, LIG3, KCNQ1, KCNH2, NPPA
negative regulation of potassium ion transport (GO:0043267)	6.26	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
negative regulation of ion transport (GO:0043271)	4.94	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
metabolic process (GO:0008152)	0.58	6	AKAP9, KCNE1, LIG3, KCNQ1, KCNH2, NPPA
regulation of delayed rectifier potassium channel activity (GO:1902259)	6.84	6	KCNE1, KCNE3, NOS1AP, KCNQ1, KCNE2, NPPA
positive regulation of cation channel activity (GO:2001259)	6.17	6	ANK2, NOS1AP, KCNE3, KCNE2, CACNB2, NPPA
intracellular signal transduction (GO:0035556)	2.39	6	CACNA1C, AKAP9, RYR2, CASQ2, KCNH2, ANK2
negative regulation of potassium ion transmembrane transport (GO:1901380)	6.68	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
response to purine-containing compound (GO:0014074)	4.67	6	AKAP9, RYR2, CASQ2, HCN4, KCNQ1, KCNE1
negative regulation of transmembrane transport (GO:0034763)	5.38	6	KCNE1, KCNE3, KCNQ1, KCNE2, KCNH2, CASQ2
negative regulation of transporter activity (GO:0032410)	5.59	5	KCNQ1, KCNE1, CASQ2, KCNE3, KCNE2
negative regulation of ion transmembrane transporter activity (GO:0032413)	5.74	5	KCNQ1, KCNE1, CASQ2, KCNE3, KCNE2
ion homeostasis (GO:0050801)	3.42	5	CACNA1C, KCNJ2, RYR2, KCNH2, ANK2
metal ion homeostasis (GO:0055065)	3.61	5	KCNJ2, CACNA1C, RYR2, KCNH2, ANK2
regulation of response to stimulus (GO:0048583)	1.54	5	KCNQ1, JUP, CASQ2, NOS1AP, KCNE2
membrane repolarization during cardiac muscle cell action potential (GO:0086013)	7.43	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
homeostatic process (GO:0042592)	2.61	5	KCNJ2, CACNA1C, RYR2, KCNH2, ANK2
cell-cell signaling (GO:0007267)	3.35	5	AKAP9, CACNB2, CASQ2, RYR2, SCN1B
inorganic ion homeostasis (GO:0098771)	3.43	5	KCNJ2, CACNA1C, RYR2, KCNH2, ANK2
cell communication involved in cardiac conduction (GO:0086065)	6.73	5	CACNA1C, SCN5A, RYR2, CASQ2, ANK2
regulation of voltage-gated calcium channel activity (GO:1901385)	6.59	5	CACNB2, KCNE3, NOS1AP, KCNE2, NPPA
cellular macromolecule metabolic process (GO:0044260)	0.93	5	AKAP9, KCNE1, KCNH2, LIG3, NPPA
membrane repolarization (GO:0086009)	7.02	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	6.36	5	RYR2, CACNB2, KCNE3, ANK2, KCNE2
negative regulation of molecular function (GO:0044092)	2.74	5	KCNQ1, KCNE1, CASQ2, KCNE3, KCNE2
regulation of ventricular cardiac muscle cell action potential (GO:0098911)	7.33	5	CACNA1C, RYR2, JUP, DSG2, NOS1AP
regulation of gene expression (GO:0010468)	1.37	5	JUP, KCNQ1, RYR2, ANK2, NOS1AP
macromolecule metabolic process (GO:0043170)	0.83	5	AKAP9, KCNH2, KCNE1, NPPA, LIG3
negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.96	5	KCNQ1, KCNE1, CASQ2, KCNE3, KCNE2
positive regulation of blood circulation (GO:1903524)	5.16	5	KCNQ1, RYR2, SCN5A, NOS1AP, NPPA
positive regulation of calcium ion transmembrane transport (GO:1904427)	5.69	5	RYR2, KCNE3, ANK2, KCNE2, CACNB2
cation homeostasis (GO:0055080)	3.46	5	KCNJ2, CACNA1C, RYR2, KCNH2, ANK2
divalent metal ion transport (GO:0070838)	4.15	5	CACNA1C, KCNJ2, RYR2, CACNB2, ANK2
membrane repolarization during action potential (GO:0086011)	7.43	5	KCNJ2, KCNH2, KCNE1, KCNE2, KCNQ1
response to abiotic stimulus (GO:0009628)	2.8	5	KCNJ2, JUP, KCNJ8, RYR2, NPPA
divalent inorganic cation transport (GO:0072511)	4.13	5	CACNA1C, KCNJ2, CACNB2, RYR2, ANK2
response to external stimulus (GO:0009605)	2.55	5	KCNJ2, RYR2, KCNJ8, JUP, NPPA
positive regulation of calcium ion transport (GO:0051928)	5.06	5	RYR2, CACNB2, KCNE3, ANK2, KCNE2
chemical homeostasis (GO:0048878)	2.97	5	KCNJ2, CACNA1C, RYR2, KCNH2, ANK2
cardiac muscle cell membrane repolarization (GO:0099622)	7.43	5	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
positive regulation of heart contraction (GO:0045823)	6.15	5	KCNQ1, RYR2, SCN5A, NOS1AP, NPPA
negative regulation of cation channel activity (GO:2001258)	6.26	5	KCNQ1, KCNE1, CASQ2, KCNE3, KCNE2
cellular homeostasis (GO:0019725)	3.23	4	KCNJ2, CACNA1C, RYR2, ANK2
cellular component assembly (GO:0022607)	2.14	4	KCNJ2, JUP, CASQ2, ANK2
positive regulation of metabolic process (GO:0009893)	1.74	4	AKAP9, NOS1AP, ANK2, KCNE2
regulation of cardiac conduction (GO:1903779)	5.57	4	RYR2, CASQ2, NPPA, ANK2
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	6.68	4	CACNA1C, RYR2, CASQ2, ANK2
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	JUP, RYR2, LIG3, NOS1AP
regulation of sequestering of calcium ion (GO:0051282)	5.07	4	CACNA1C, RYR2, CASQ2, ANK2
regulation of cellular component organization (GO:0051128)	2.01	4	LIG3, KCNE1, SCN1B, NPPA
second-messenger-mediated signaling (GO:0019932)	4.65	4	CACNA1C, RYR2, CASQ2, ANK2
negative regulation of voltage-gated potassium channel activity (GO:1903817)	7.53	4	KCNQ1, KCNE1, KCNE3, KCNE2
potassium ion import (GO:0010107)	6.4	4	KCNJ2, KCNJ8, KCNJ5, KCNE2
cellular protein metabolic process (GO:0044267)	1.63	4	AKAP9, KCNH2, KCNE1, NPPA
single-organism metabolic process (GO:0044710)	1.63	4	AKAP9, KCNH2, KCNE1, NPPA
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	AKAP9, NOS1AP, ANK2, KCNE2
regulation of signal transduction (GO:0009966)	1.84	4	JUP, CASQ2, NOS1AP, KCNE2
regulation of protein metabolic process (GO:0051246)	1.93	4	AKAP9, SNTA1, NOS1AP, KCNE2
response to mechanical stimulus (GO:0009612)	4.41	4	KCNJ2, JUP, RYR2, NPPA
sodium ion transmembrane transport (GO:0035725)	5.23	4	SCN5A, SCN4B, HCN4, SCN1B
animal organ development (GO:0048513)	2.53	4	CACNA1C, JUP, KCNJ8, KCNE2
positive regulation of heart rate (GO:0010460)	6.59	4	KCNQ1, RYR2, SCN5A, NPPA
response to organophosphorus (GO:0046683)	4.79	4	AKAP9, KCNQ1, KCNE1, HCN4
regulation of sodium ion transport (GO:0002028)	5.4	4	SCN5A, SNTA1, SCN4B, SCN1B
ventricular cardiac muscle cell membrane repolarization (GO:0099625)	8.34	4	KCNQ1, KCNH2, KCNE1, KCNE2
regulation of sodium ion transmembrane transport (GO:1902305)	5.86	4	SCN5A, SNTA1, SCN4B, SCN1B
positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	6.96	4	AKAP9, NOS1AP, NPPA, ANK2
negative regulation of delayed rectifier potassium channel activity (GO:1902260)	7.53	4	KCNQ1, KCNE1, KCNE3, KCNE2
calcium-mediated signaling (GO:0019722)	5.24	4	CACNA1C, RYR2, CASQ2, ANK2
cellular metal ion homeostasis (GO:0006875)	3.75	4	CACNA1C, KCNJ2, RYR2, ANK2
neurological system process (GO:0050877)	2.64	4	KCNQ1, CACNB2, KCNE1, SCN1B
regulation of biosynthetic process (GO:0009889)	1.37	4	JUP, RYR2, LIG3, NOS1AP
potassium ion export (GO:0071435)	7.43	4	KCNQ1, KCNH2, KCNE1, KCNE2
cellular ion homeostasis (GO:0006873)	3.57	4	CACNA1C, KCNJ2, RYR2, ANK2
calcium ion transport (GO:0006816)	4.33	4	CACNA1C, CACNB2, RYR2, ANK2
establishment of protein localization (GO:0045184)	2.53	4	JUP, CACNB2, RYR2, ANK2
response to stress (GO:0006950)	1.8	4	RYR2, KCNJ8, NPPA, LIG3
response to cAMP (GO:0051591)	5.08	4	AKAP9, KCNQ1, KCNE1, HCN4
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	JUP, RYR2, LIG3, NOS1AP
cellular cation homeostasis (GO:0030003)	3.6	4	CACNA1C, KCNJ2, RYR2, ANK2
regulation of postsynaptic membrane potential (GO:0060078)	5.72	4	SCN5A, SCN4B, HCN4, SCN1B
cellular chemical homeostasis (GO:0055082)	3.4	4	KCNJ2, CACNA1C, RYR2, ANK2
sodium ion transport (GO:0006814)	4.75	4	SCN5A, SCN4B, HCN4, SCN1B
regulation of calcium ion import (GO:0090279)	5.08	4	CACNA1C, RYR2, CASQ2, ANK2
organelle organization (GO:0006996)	2.02	4	AKAP9, JUP, CASQ2, LIG3
regulation of cellular protein metabolic process (GO:0032268)	1.99	4	AKAP9, SNTA1, NOS1AP, KCNE2
protein metabolic process (GO:0019538)	1.45	4	AKAP9, KCNH2, KCNE1, NPPA
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	5.44	4	CACNA1C, RYR2, CASQ2, ANK2
cellular response to cAMP (GO:0071320)	5.82	4	AKAP9, KCNQ1, KCNE1, HCN4
membrane repolarization during ventricular cardiac muscle cell action potential (GO:0098915)	8.34	4	KCNQ1, KCNE1, KCNE2, KCNH2
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	4	CACNA1C, RYR2, CASQ2, ANK2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	6.9	4	CACNA1C, RYR2, CASQ2, ANK2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.59	4	CACNA1C, RYR2, CASQ2, ANK2
negative regulation of metabolic process (GO:0009892)	1.93	3	SNTA1, KCNQ1, LIG3
cell-cell junction organization (GO:0045216)	4.66	3	JUP, ANK2, DSG2
macromolecular complex subunit organization (GO:0043933)	2.14	3	KCNJ2, JUP, CASQ2
calcium ion transmembrane transport (GO:0070588)	4.67	3	CACNA1C, CACNB2, RYR2
calcium ion homeostasis (GO:0055074)	3.97	3	CACNA1C, RYR2, ANK2
cell junction organization (GO:0034330)	4.51	3	JUP, ANK2, DSG2
cellular response to drug (GO:0035690)	5.48	3	KCNH2, KCNQ1, KCNE2
positive regulation of muscle contraction (GO:0045933)	5.9	3	NOS1AP, KCNQ1, NPPA
single-organism organelle organization (GO:1902589)	2.68	3	AKAP9, JUP, CASQ2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	KCNQ1, NPPA, LIG3
circulatory system process (GO:0003013)	4.38	3	KCNJ8, NPPA, HCN4
nitrogen compound metabolic process (GO:0006807)	1.13	3	KCNQ1, NPPA, LIG3
positive regulation of striated muscle contraction (GO:0045989)	6.96	3	NOS1AP, KCNQ1, NPPA
anatomical structure morphogenesis (GO:0009653)	2.53	3	CACNA1C, RYR2, SCN5A
establishment of protein localization to plasma membrane (GO:0090002)	5.2	3	CACNB2, JUP, ANK2
organic cyclic compound metabolic process (GO:1901360)	1.26	3	KCNQ1, NPPA, LIG3
regulation of protein localization (GO:0032880)	2.88	3	CACNA1C, JUP, KCNE1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	KCNQ1, LIG3, NPPA
regulation of protein transport (GO:0051223)	3.12	3	CACNA1C, JUP, KCNE1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	SNTA1, KCNQ1, LIG3
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	3	CACNA1C, RYR2, ANK2
protein complex subunit organization (GO:0071822)	2.6	3	KCNJ2, JUP, CASQ2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	JUP, RYR2, LIG3
positive regulation of protein metabolic process (GO:0051247)	2.43	3	AKAP9, NOS1AP, KCNE2
macromolecular complex assembly (GO:0065003)	2.55	3	KCNJ2, JUP, CASQ2
chemical synaptic transmission (GO:0007268)	3.98	3	AKAP9, CACNB2, SCN1B
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	AKAP9, NOS1AP, KCNE2
positive regulation of catalytic activity (GO:0043085)	2.4	3	AKAP9, RYR2, NOS1AP
regulation of protein modification process (GO:0031399)	2.32	3	AKAP9, SNTA1, NOS1AP
regulation of high voltage-gated calcium channel activity (GO:1901841)	7.65	3	CACNB2, NOS1AP, NPPA
positive regulation of voltage-gated calcium channel activity (GO:1901387)	7.94	3	CACNB2, KCNE3, KCNE2
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	AKAP9, NOS1AP, KCNE2
positive regulation of sodium ion transport (GO:0010765)	6.23	3	SCN5A, SCN4B, SCN1B
regulation of establishment of protein localization (GO:0070201)	3.02	3	CACNA1C, JUP, KCNE1
regulation of catalytic activity (GO:0050790)	1.97	3	AKAP9, RYR2, NOS1AP
divalent inorganic cation homeostasis (GO:0072507)	3.9	3	CACNA1C, RYR2, ANK2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	JUP, RYR2, LIG3
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	KCNQ1, NPPA, LIG3
protein complex assembly (GO:0006461)	2.78	3	KCNJ2, JUP, CASQ2
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372)	7.94	3	KCNQ1, SCN5A, NPPA
sensory perception (GO:0007600)	2.93	3	KCNQ1, CACNB2, KCNE1
cellular protein modification process (GO:0006464)	1.79	3	AKAP9, KCNH2, KCNE1
response to calcium ion (GO:0051592)	4.98	3	SCN5A, RYR2, CASQ2
macromolecule modification (GO:0043412)	1.73	3	AKAP9, KCNH2, KCNE1
protein modification process (GO:0036211)	1.79	3	AKAP9, KCNH2, KCNE1
cell adhesion (GO:0007155)	2.82	3	JUP, SCN1B, DSG2
response to metal ion (GO:0010038)	3.91	3	SCN5A, RYR2, CASQ2
establishment of localization in cell (GO:0051649)	2.47	3	CACNA1C, RYR2, ANK2
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel (GO:1902514)	8.12	3	CACNB2, NOS1AP, NPPA
cytoskeleton organization (GO:0007010)	3.22	3	AKAP9, JUP, CASQ2
response to inorganic substance (GO:0010035)	3.56	3	CASQ2, RYR2, SCN5A
SA node cell action potential (GO:0086015)	7.94	3	SCN5A, HCN4, ANK2
heterocycle metabolic process (GO:0046483)	1.31	3	KCNQ1, LIG3, NPPA
cellular calcium ion homeostasis (GO:0006874)	4.01	3	CACNA1C, RYR2, ANK2
anterograde trans-synaptic signaling (GO:0098916)	3.98	3	AKAP9, CACNB2, SCN1B
detection of stimulus (GO:0051606)	3.22	3	JUP, CASQ2, RYR2
biological adhesion (GO:0022610)	2.81	3	JUP, SCN1B, DSG2
establishment of protein localization to membrane (GO:0090150)	4.14	3	CACNB2, JUP, ANK2
response to drug (GO:0042493)	3.71	3	KCNQ1, KCNH2, KCNE2
regulation of membrane depolarization (GO:0003254)	6.04	3	SCN5A, HCN4, SCN1B
immune system process (GO:0002376)	2.29	3	CACNA1C, KCNJ8, LIG3
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	AKAP9, KCNH2, NPPA
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	JUP, RYR2, LIG3
positive regulation of cardiac muscle contraction (GO:0060452)	7.24	3	NOS1AP, KCNQ1, NPPA
phosphorus metabolic process (GO:0006793)	2.15	3	AKAP9, KCNH2, NPPA
system development (GO:0048731)	2.92	3	CACNA1C, KCNQ1, ANK2
trans-synaptic signaling (GO:0099537)	3.98	3	AKAP9, CACNB2, SCN1B
synaptic signaling (GO:0099536)	3.98	3	AKAP9, CACNB2, SCN1B
membrane depolarization during AV node cell action potential (GO:0086045)	8.34	3	CACNA1C, CACNB2, SCN5A
regulation of intracellular protein transport (GO:0033157)	3.8	2	JUP, KCNE1
heterotypic cell-cell adhesion (GO:0034113)	6.43	2	JUP, DSG2
regulation of secretion (GO:0051046)	3.2	2	CACNA1C, KCNQ1
regulation of intracellular transport (GO:0032386)	3.58	2	JUP, KCNE1
positive regulation of response to stimulus (GO:0048584)	2.18	2	JUP, NOS1AP
positive regulation of homeostatic process (GO:0032846)	4.38	2	RYR2, CASQ2
negative regulation of homeostatic process (GO:0032845)	4.91	2	RYR2, CASQ2
cardiac muscle cell-cardiac muscle cell adhesion (GO:0086042)	7.94	2	JUP, DSG2
potassium ion homeostasis (GO:0055075)	6.84	2	KCNJ2, KCNH2
cell surface receptor signaling pathway (GO:0007166)	2.09	2	RYR2, NPPA
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	RYR2, NPPA
vascular process in circulatory system (GO:0003018)	4.65	2	KCNJ8, NPPA
detection of chemical stimulus (GO:0009593)	3.49	2	RYR2, CASQ2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	2	LIG3, NPPA
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	AKAP9, KCNH2
positive regulation of signal transduction (GO:0009967)	2.5	2	JUP, NOS1AP
cell junction assembly (GO:0034329)	4.86	2	JUP, ANK2
regulation of SA node cell action potential (GO:0098907)	9.04	2	RYR2, ANK2
positive regulation of sequestering of calcium ion (GO:0051284)	7.09	2	RYR2, CASQ2
regulation of cell proliferation (GO:0042127)	2.41	2	JUP, SCN5A
regulation of potassium ion export (GO:1902302)	8.63	2	KCNH2, NPPA
sensory perception of sound (GO:0007605)	4.82	2	KCNQ1, KCNE1
positive regulation of voltage-gated potassium channel activity (GO:1903818)	8.12	2	NOS1AP, NPPA
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	JUP, RYR2
desmosome organization (GO:0002934)	7.53	2	JUP, DSG2
multi-organism process (GO:0051704)	2.65	2	KCNJ8, NPPA
positive regulation of signaling (GO:0023056)	2.41	2	JUP, NOS1AP
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	CACNA1C, RYR2
regulation of atrial cardiac muscle cell action potential (GO:0098910)	8.12	2	RYR2, ANK2
membrane depolarization during atrial cardiac muscle cell action potential (GO:0098912)	9.04	2	CACNA1C, CACNB2
aromatic compound biosynthetic process (GO:0019438)	1.7	2	NPPA, LIG3
heterocycle biosynthetic process (GO:0018130)	1.7	2	LIG3, NPPA
membrane depolarization during SA node cell action potential (GO:0086046)	8.34	2	SCN5A, ANK2
cellular response to mechanical stimulus (GO:0071260)	5.33	2	KCNJ2, NPPA
membrane depolarization during Purkinje myocyte cell action potential (GO:0086047)	9.04	2	SCN5A, SCN1B
movement of cell or subcellular component (GO:0006928)	2.61	2	JUP, SCN1B
positive regulation of gene expression (GO:0010628)	2.35	2	NOS1AP, ANK2
response to monoamine (GO:0071867)	6.17	2	RYR2, KCNQ1
cellular response to monoamine stimulus (GO:0071868)	6.29	2	RYR2, KCNQ1
response to catecholamine (GO:0071869)	6.23	2	RYR2, KCNQ1
response to muscle stretch (GO:0035994)	6.78	2	RYR2, NPPA
organic substance biosynthetic process (GO:1901576)	1.34	2	NPPA, LIG3
positive regulation of hydrolase activity (GO:0051345)	2.91	2	AKAP9, RYR2
Purkinje myocyte to ventricular cardiac muscle cell signaling (GO:0086029)	9.04	2	RYR2, CASQ2
regulation of anatomical structure size (GO:0090066)	3.78	2	KCNJ8, NPPA
regulation of sodium ion transmembrane transporter activity (GO:2000649)	6.09	2	SCN4B, SCN1B
cellular response to abiotic stimulus (GO:0071214)	4.15	2	KCNJ2, NPPA
calcium ion import (GO:0070509)	5.57	2	CACNB2, RYR2
regulation of tube size (GO:0035150)	4.79	2	KCNJ8, NPPA
single organism cell adhesion (GO:0098602)	3.63	2	JUP, DSG2
cell-cell adhesion (GO:0098609)	3.34	2	JUP, DSG2
sensory perception of mechanical stimulus (GO:0050954)	4.79	2	KCNQ1, KCNE1
response to caffeine (GO:0031000)	6.84	2	RYR2, CASQ2
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	7.65	2	SCN5A, SCN1B
cellular response to epinephrine stimulus (GO:0071872)	7.24	2	RYR2, KCNQ1
response to epinephrine (GO:0071871)	6.96	2	RYR2, KCNQ1
cellular response to catecholamine stimulus (GO:0071870)	6.33	2	RYR2, KCNQ1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	2	LIG3, NPPA
maintenance of location (GO:0051235)	4.77	2	JUP, CASQ2
regulation of intracellular signal transduction (GO:1902531)	2.31	2	NOS1AP, CASQ2
regulation of hydrolase activity (GO:0051336)	2.53	2	AKAP9, RYR2
potassium ion export across plasma membrane (GO:0097623)	9.04	2	KCNH2, KCNQ1
regulation of heart rate by chemical signal (GO:0003062)	8.12	2	NOS1AP, KCNH2
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	NPPA, LIG3
sensory organ development (GO:0007423)	4.82	2	CACNA1C, KCNE2
response to decreased oxygen levels (GO:0036293)	4.09	2	RYR2, NPPA
positive regulation of protein modification process (GO:0031401)	2.7	2	AKAP9, NOS1AP
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	JUP, RYR2
muscle hypertrophy (GO:0014896)	6.68	2	RYR2, NPPA
striated muscle hypertrophy (GO:0014897)	6.78	2	RYR2, NPPA
phosphorylation (GO:0016310)	2.63	2	AKAP9, KCNH2
negative regulation of cellular component organization (GO:0051129)	3.35	2	KCNE1, LIG3
regulation of cellular protein localization (GO:1903827)	3.43	2	JUP, KCNE1
cellular biosynthetic process (GO:0044249)	1.37	2	LIG3, NPPA
cell-cell junction assembly (GO:0007043)	5.42	2	JUP, ANK2
regulation of protein targeting (GO:1903533)	4.0	2	JUP, KCNE1
cell communication by electrical coupling (GO:0010644)	7.02	2	CACNA1C, RYR2
positive regulation of cell communication (GO:0010647)	2.41	2	JUP, NOS1AP
response to hypoxia (GO:0001666)	4.13	2	RYR2, NPPA
regulation of blood vessel size (GO:0050880)	4.8	2	KCNJ8, NPPA
cardiac muscle hypertrophy (GO:0003300)	6.84	2	RYR2, NPPA
RNA metabolic process (GO:0016070)	1.59	2	LIG3, NPPA
cellular response to external stimulus (GO:0071496)	4.2	2	KCNJ2, NPPA
positive regulation of delayed rectifier potassium channel activity (GO:1902261)	8.12	2	NOS1AP, NPPA
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	JUP, RYR2
cell-cell signaling involved in cardiac conduction (GO:0086019)	8.12	2	RYR2, CASQ2
response to alkaloid (GO:0043279)	4.83	2	RYR2, CASQ2
AV node cell action potential (GO:0086016)	8.34	2	SCN5A, SCN4B
atrial cardiac muscle cell action potential (GO:0086014)	7.65	2	KCNQ1, ANK2
protein oligomerization (GO:0051259)	3.71	2	KCNJ2, JUP
regulation of peptidyl-cysteine S-nitrosylation (GO:2000169)	8.12	2	SNTA1, NOS1AP
response to hormone (GO:0009725)	3.33	2	NPPA, DSG2
regulation of RNA metabolic process (GO:0051252)	1.52	2	JUP, RYR2
detection of calcium ion (GO:0005513)	7.24	2	RYR2, CASQ2
single organismal cell-cell adhesion (GO:0016337)	3.69	2	JUP, DSG2
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	SNTA1, LIG3
nucleic acid metabolic process (GO:0090304)	1.46	2	NPPA, LIG3
Purkinje myocyte to ventricular cardiac muscle cell communication (GO:0086068)	9.04	2	RYR2, CASQ2
cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	7.16	2	CACNA1C, RYR2
positive regulation of action potential (GO:0045760)	7.33	2	NOS1AP, SCN5A
response to lipid (GO:0033993)	3.11	2	KCNJ8, DSG2
sarcoplasmic reticulum calcium ion transport (GO:0070296)	7.33	2	RYR2, ANK2
cellular response to alkaloid (GO:0071312)	6.2	2	RYR2, CASQ2
cellular response to caffeine (GO:0071313)	7.65	2	RYR2, CASQ2
regulation of receptor activity (GO:0010469)	4.98	2	CASQ2, KCNE2
embryonic morphogenesis (GO:0048598)	3.72	2	CACNA1C, RYR2
protein phosphorylation (GO:0006468)	2.89	2	AKAP9, KCNH2
cytosolic calcium ion transport (GO:0060401)	5.74	2	CACNA1C, RYR2
calcium ion transport into cytosol (GO:0060402)	5.78	2	CACNA1C, RYR2
homotypic cell-cell adhesion (GO:0034109)	5.76	2	JUP, DSG2
reproductive process (GO:0022414)	2.55	2	NPPA, DSG2
biosynthetic process (GO:0009058)	1.32	2	NPPA, LIG3
macromolecule biosynthetic process (GO:0009059)	1.61	2	LIG3, NPPA
monovalent inorganic cation homeostasis (GO:0055067)	4.93	2	KCNJ2, KCNH2
bundle of His cell-Purkinje myocyte adhesion involved in cell communication (GO:0086073)	7.94	2	JUP, DSG2
response to oxygen levels (GO:0070482)	4.02	2	RYR2, NPPA
locomotion (GO:0040011)	2.91	2	JUP, SCN1B
heart development (GO:0007507)	4.24	2	CACNA1C, KCNJ8
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	CACNA1C, RYR2
cellular response to purine-containing compound (GO:0071415)	7.53	2	RYR2, CASQ2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of peptide transport (GO:0090087)	NEW	4.37	0.002	CACNA1C, RYR2, NPPA, KCNH2, KCNQ1, JUP, ANK2, KCNJ8
protein localization (GO:0008104)	NEW	2.36	0.015	AKAP9, RYR2, SCN5A, NPPA, KCNH2, KCNQ1, KCNE2, JUP, ANK2, SCN1B
regulation of transport (GO:0051049)	-	2.24	0.0	CACNA1C, KCNJ2, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNQ1, CACNB2, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
regulation of homeostatic process (GO:0032844)	-	3.65	0.002	CACNA1C, RYR2, SCN5A, ANK2, CASQ2, SCN1B
potassium ion import (GO:0010107)	-	6.4	0.0	KCNJ2, KCNH2, KCNJ8, KCNE2
membrane depolarization (GO:0051899)	-	5.62	0.0	CACNA1C, SCN4B, KCNH2, KCNJ2, ANK2, SCN5A, SNTA1, SCN1B
circulatory system process (GO:0003013)	-	4.38	0.002	RYR2, CASQ2, NPPA, HCN4, JUP, ANK2, KCNJ8
membrane depolarization during SA node cell action potential (GO:0086046)	-	8.34	0.004	SCN5A, ANK2
action potential (GO:0001508)	-	5.42	0.0	CACNA1C, RYR2, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.0	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE1, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, KCNJ8, SCN1B
positive regulation of ion transmembrane transport (GO:0034767)	-	5.05	0.0	KCNJ2, KCNQ1, RYR2, KCNE1, KCNH2
regulation of transmembrane transport (GO:0034762)	-	3.74	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, KCNE2, KCNQ1, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, KCNJ2, SCN1B
potassium ion export (GO:0071435)	-	7.43	0.0	KCNQ1, KCNH2, KCNE1, KCNE2
regulation of localization (GO:0032879)	-	1.94	0.0	CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNE3, KCNE1, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B
response to organic substance (GO:0010033)	-	2.2	0.045	RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, DSG2, JUP, ANK2, KCNE1, KCNJ8
macromolecule localization (GO:0033036)	NEW	2.34	0.018	AKAP9, RYR2, SCN5A, NPPA, KCNH2, KCNQ1, KCNE2, JUP, ANK2, SCN1B
regulation of calcium ion transport into cytosol (GO:0010522)	-	5.23	0.002	CACNA1C, RYR2, CASQ2, ANK2
positive regulation of heart rate (GO:0010460)	-	6.59	0.032	RYR2, SCN5A, NPPA
regulation of sodium ion transmembrane transport (GO:1902305)	-	5.86	0.0	SCN5A, SNTA1, SCN4B, SCN1B
negative regulation of transport (GO:0051051)	-	3.6	0.046	CACNA1C, RYR2, CASQ2, NPPA, KCNH2, KCNQ1, JUP, ANK2, KCNJ8
regulation of muscle contraction (GO:0006937)	-	4.75	0.0	CACNA1C, RYR2, SCN5A, NPPA, KCNJ2, ANK2, CASQ2
sensory perception of sound (GO:0007605)	-	4.82	0.041	AKAP9, SCN5A, KCNQ1, KCNH2, KCNE1, SCN1B
sensory perception (GO:0007600)	-	2.93	0.005	CACNA1C, AKAP9, RYR2, KCNE1, NPPA, KCNQ1, KCNH2, CACNB2, ANK2, SCN5A, SCN1B
adult walking behavior (GO:0007628)	NEW	6.23	0.045	CACNA1C, SCN5A, SCN1B, ANK2
regulation of peptide hormone secretion (GO:0090276)	NEW	4.41	0.001	CACNA1C, RYR2, NPPA, KCNQ1, KCNH2, JUP, ANK2, KCNJ8
regulation of potassium ion transmembrane transport (GO:1901379)	-	5.62	0.0	RYR2, CASQ2, KCNH2, KCNQ1, KCNE2, KCNJ2, ANK2, KCNE1
divalent inorganic cation transport (GO:0072511)	-	4.13	0.013	CACNA1C, KCNJ2, CACNB2, RYR2, ANK2
regulation of cardiac muscle contraction (GO:0055117)	-	5.57	0.0	CACNA1C, SCN5A, RYR2, CASQ2, ANK2
system process (GO:0003008)	-	2.3	0.0	CACNA1C, RYR2, KCNE1, NPPA, HCN4, KCNQ1, CASQ2, KCNH2, KCNJ2, CACNB2, ANK2, SCN5A, SNTA1, SCN4B, KCNJ8, SCN1B
single organism signaling (GO:0044700)	-	3.25	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, KCNJ5, HCN4, KCNH2, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, ANK2, DSG2, NPPA, CASQ2, SNTA1, SCN4B, KCNJ8, SCN1B
single-multicellular organism process (GO:0044707)	-	1.78	0.0	CACNA1C, RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNH2, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
response to organonitrogen compound (GO:0010243)	-	3.2	0.015	AKAP9, CACNA1C, RYR2, CASQ2, NPPA, HCN4, KCNH2, KCNQ1, JUP, ANK2, KCNE1, KCNJ8
cellular response to cAMP (GO:0071320)	-	5.82	0.036	KCNQ1, KCNH2, KCNE1, HCN4
muscle system process (GO:0003012)	-	4.18	0.0	CACNA1C, RYR2, CASQ2, NPPA, HCN4, KCNQ1, KCNH2, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B, SCN1B
response to organophosphorus (GO:0046683)	-	4.79	0.0	RYR2, CASQ2, HCN4, KCNH2, KCNQ1, ANK2, KCNE1, KCNJ8
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	-	6.68	0.0	CACNA1C, RYR2, CASQ2, ANK2
regulation of delayed rectifier potassium channel activity (GO:1902259)	-	6.84	0.008	KCNQ1, KCNE1, KCNE2, KCNH2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	-	6.59	0.0	CACNA1C, RYR2, CASQ2, ANK2
regulation of cell communication by electrical coupling (GO:0010649)	NEW	7.33	0.002	CACNA1C, RYR2, CASQ2
positive regulation of ion transmembrane transporter activity (GO:0032414)	-	5.55	0.035	RYR2, CASQ2, NPPA, ANK2
regulation of membrane potential (GO:0042391)	-	3.89	0.0	CACNA1C, AKAP9, RYR2, SCN5A, SCN4B, NPPA, HCN4, KCNQ1, CASQ2, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN1B
regulation of ion transmembrane transporter activity (GO:0032412)	-	4.55	0.0	CACNA1C, RYR2, SCN5A, CASQ2, NPPA, KCNQ1, KCNH2, KCNE2, ANK2, KCNE1, SCN4B, KCNJ8, SCN1B
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	-	6.84	0.0	SCN5A, KCNH2, KCNQ1, KCNE2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of membrane repolarization (GO:0060306)	-	6.4	0.0	RYR2, CASQ2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, ANK2, SCN5A, SNTA1, SCN4B, SCN1B
positive regulation of transmembrane transport (GO:0034764)	-	4.99	0.0	KCNQ1, KCNH2, RYR2, KCNE1, KCNJ2
second-messenger-mediated signaling (GO:0019932)	-	4.65	0.02	CACNA1C, RYR2, CASQ2, ANK2
regulation of biological process (GO:0050789)	-	0.45	0.002	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
cardiac muscle cell action potential involved in contraction (GO:0086002)	-	6.47	0.0	RYR2, SCN5A, KCNH2, KCNQ1, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
Purkinje myocyte to ventricular cardiac muscle cell signaling (GO:0086029)	-	9.04	0.003	RYR2, CASQ2
biological regulation (GO:0065007)	-	0.39	0.004	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.0	CACNA1C, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE1, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SNTA1, KCNJ8, SCN1B
inorganic ion transmembrane transport (GO:0098660)	-	3.38	0.0	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
regulation of biological quality (GO:0065008)	-	1.68	0.0	CACNA1C, RYR2, SCN5A, NPPA, HCN4, KCNQ1, CASQ2, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
transport (GO:0006810)	-	1.51	0.0	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	-	6.9	0.0	CACNA1C, RYR2, CASQ2, ANK2
potassium ion transport (GO:0006813)	-	4.68	0.0	CACNA1C, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
cation transport (GO:0006812)	-	3.11	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
ion transport (GO:0006811)	-	2.66	0.0	AKAP9, CACNA1C, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNH2, KCNE1, KCNQ1, JUP, KCNE2, KCNJ2, CACNB2, KCNE3, NPPA, KCNJ5, CASQ2, SNTA1, KCNJ8, SCN1B
regulation of heart contraction (GO:0008016)	-	4.35	0.0	CACNA1C, RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372)	-	7.94	0.013	KCNQ1, SCN5A
regulation of cellular process (GO:0050794)	-	0.5	0.009	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, KCNJ2, SNTA1
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	CACNA1C, RYR2, SCN5A, KCNE1, DSG2, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, SCN1B, ANK2, SCN4B, SNTA1, CASQ2
establishment of localization (GO:0051234)	-	1.48	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNQ1, CACNB2, KCNJ5, SCN4B, KCNJ8, KCNJ2, SCN1B
regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	-	7.65	0.036	SCN5A, SCN1B
cellular potassium ion transport (GO:0071804)	-	4.79	0.0	CACNA1C, KCNE1, ANK2, HCN4, KCNQ1, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNJ8
regulation of transmembrane transporter activity (GO:0022898)	-	4.52	0.0	CACNA1C, RYR2, SCN5A, SCN4B, NPPA, KCNQ1, CASQ2, KCNH2, KCNE2, ANK2, KCNE1, KCNJ8, SCN1B
response to nitrogen compound (GO:1901698)	-	3.12	0.03	CACNA1C, AKAP9, RYR2, KCNE1, NPPA, HCN4, KCNQ1, KCNH2, JUP, ANK2, CASQ2, KCNJ8
cellular response to nitrogen compound (GO:1901699)	-	3.79	0.002	AKAP9, CACNA1C, RYR2, CASQ2, HCN4, KCNH2, KCNQ1, JUP, ANK2, KCNE1, KCNJ8
sarcoplasmic reticulum calcium ion transport (GO:0070296)	-	7.33	0.006	RYR2, CASQ2, ANK2
negative regulation of cation channel activity (GO:2001258)	-	6.26	0.041	CACNA1C, RYR2, CASQ2
regulation of cation channel activity (GO:2001257)	-	5.27	0.0	CACNA1C, RYR2, CASQ2, KCNQ1, KCNE2, ANK2, KCNE1
multicellular organismal signaling (GO:0035637)	-	5.36	0.0	SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SCN1B
striated muscle contraction (GO:0006941)	-	5.37	0.0	RYR2, CASQ2, NPPA, KCNH2, KCNQ1, ANK2, SCN5A, SCN4B, SCN1B
regulation of striated muscle contraction (GO:0006942)	-	5.38	0.0	CACNA1C, RYR2, SCN5A, KCNJ2, ANK2, CASQ2
signaling (GO:0023052)	-	3.25	0.0	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, HCN4, NPPA, KCNQ1, KCNE1, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
response to chemical (GO:0042221)	-	1.98	0.007	RYR2, SCN5A, KCNE1, NPPA, HCN4, KCNH2, KCNQ1, KCNE2, JUP, DSG2, ANK2, CASQ2, KCNJ8, SCN1B
response to purine-containing compound (GO:0014074)	-	4.67	0.0	RYR2, KCNE1, HCN4, KCNH2, KCNQ1, ANK2, CASQ2, KCNJ8
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	RYR2, SCN5A, KCNH2, KCNQ1, ANK2, CASQ2, SCN4B, SCN1B
response to organic cyclic compound (GO:0014070)	-	3.07	0.0	CACNA1C, RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, KCNH2, DSG2, JUP, ANK2, KCNE1, KCNJ8
ventricular cardiac muscle cell action potential (GO:0086005)	-	7.02	0.0	RYR2, KCNE1, KCNQ1, KCNH2, KCNE2, JUP, DSG2, ANK2, SCN5A, SNTA1
cardiac muscle cell action potential (GO:0086001)	-	6.33	0.0	RYR2, SCN5A, SCN4B, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN1B
regulation of system process (GO:0044057)	-	3.53	0.0	CACNA1C, RYR2, SCN5A, KCNE1, DSG2, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, SCN1B, ANK2, SCN4B, SNTA1, NPPA, CASQ2
potassium ion transmembrane transport (GO:0071805)	-	4.79	0.0	CACNA1C, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
membrane repolarization (GO:0086009)	-	7.02	0.0	KCNJ2, KCNQ1, KCNE1, KCNE2, KCNH2
localization (GO:0051179)	-	1.4	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SCN4B, KCNJ8, SCN1B
regulation of heart rate (GO:0002027)	-	5.29	0.0	RYR2, SCN5A, CASQ2, NPPA, HCN4, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, SCN4B, SCN1B
regulation of transporter activity (GO:0032409)	-	4.45	0.0	CACNA1C, RYR2, SCN5A, CASQ2, ANK2, KCNH2, KCNQ1, KCNE2, NPPA, KCNE1, SCN4B, KCNJ8, SCN1B
monovalent inorganic cation transport (GO:0015672)	-	3.74	0.0	CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
regulation of sodium ion transport (GO:0002028)	-	5.4	0.001	SCN5A, SNTA1, SCN4B, SCN1B, ANK2
positive regulation of sodium ion transport (GO:0010765)	-	6.23	0.001	SCN5A, SCN4B, SCN1B, ANK2
multicellular organismal process (GO:0032501)	-	1.45	0.0	CACNA1C, RYR2, SCN5A, KCNE1, NPPA, HCN4, KCNQ1, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, DSG2, ANK2, SCN4B, SNTA1, KCNJ8, SCN1B
regulation of calcium ion transmembrane transporter activity (GO:1901019)	-	5.49	0.024	CACNA1C, RYR2, CASQ2, ANK2
neurological system process (GO:0050877)	-	2.64	0.01	AKAP9, CACNA1C, RYR2, KCNE1, NPPA, KCNQ1, KCNH2, CACNB2, ANK2, SCN5A, SNTA1, KCNJ8, SCN1B
positive regulation of ion transport (GO:0043270)	-	4.36	0.0	RYR2, SCN5A, KCNE1, NPPA, KCNQ1, KCNH2, KCNJ2, CACNB2, ANK2, SCN4B, SCN1B
cell-cell signaling involved in cardiac conduction (GO:0086019)	-	8.12	0.004	RYR2, CASQ2
regulation of hormone secretion (GO:0046883)	NEW	4.18	0.006	CACNA1C, RYR2, NPPA, KCNH2, KCNQ1, JUP, ANK2, KCNJ8
metal ion transport (GO:0030001)	-	3.36	0.0	CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, CASQ2, SNTA1, SCN4B, KCNJ8, SCN1B
membrane repolarization during cardiac muscle cell action potential (GO:0086013)	-	7.43	0.0	KCNJ2, KCNQ1, KCNE1, KCNH2
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	-	7.09	0.0	KCNJ2, SCN5A, SCN4B, SCN1B, ANK2
membrane repolarization during action potential (GO:0086011)	-	7.43	0.0	KCNJ2, KCNH2, KCNE1, KCNE2, KCNQ1
membrane depolarization during action potential (GO:0086010)	-	6.07	0.0	CACNA1C, SCN5A, KCNH2, KCNJ2, ANK2, SCN4B, SNTA1, SCN1B
transmembrane transport (GO:0055085)	-	2.72	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNE3, KCNE1, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
atrial cardiac muscle cell action potential (GO:0086014)	-	7.65	0.002	KCNQ1, SCN5A, ANK2
divalent metal ion transport (GO:0070838)	-	4.15	0.012	CACNA1C, KCNJ2, RYR2, CACNB2, ANK2
cellular response to organic cyclic compound (GO:0071407)	-	3.93	0.001	CACNA1C, RYR2, KCNE1, NPPA, HCN4, KCNH2, KCNQ1, JUP, ANK2, CASQ2, KCNJ8
response to drug (GO:0042493)	-	3.71	0.034	RYR2, CASQ2, NPPA, KCNH2, KCNQ1, KCNE2, ANK2, SCN5A, KCNJ8
regulation of heart rate by cardiac conduction (GO:0086091)	-	6.33	0.0	SCN5A, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SCN4B, SCN1B
calcium-mediated signaling (GO:0019722)	-	5.24	0.002	CACNA1C, RYR2, CASQ2, ANK2
regulation of calcium ion transmembrane transport (GO:1903169)	-	4.98	0.024	CACNA1C, RYR2, CASQ2, ANK2
negative regulation of potassium ion transport (GO:0043267)	-	6.26	0.032	KCNH2, RYR2, CASQ2
regulation of potassium ion transport (GO:0043266)	-	5.31	0.0	RYR2, KCNE1, KCNQ1, KCNE3, KCNE2, KCNJ2, ANK2, KCNH2, CASQ2
cellular response to drug (GO:0035690)	-	5.48	0.0	RYR2, CASQ2, KCNH2, KCNQ1, KCNE2, NPPA
Purkinje myocyte to ventricular cardiac muscle cell communication (GO:0086068)	-	9.04	0.003	RYR2, CASQ2
bundle of His cell to Purkinje myocyte communication (GO:0086069)	NEW	9.04	0.001	JUP, SCN5A, DSG2
AV node cell to bundle of His cell communication (GO:0086067)	NEW	8.34	0.013	SCN5A, SCN4B
generation of precursor metabolites and energy (GO:0006091)	NEW	4.07	0.041	CACNA1C, RYR2, NPPA, KCNH2, KCNQ1, TANGO2, ANK2, KCNJ8
cell communication involved in cardiac conduction (GO:0086065)	-	6.73	0.0	CACNA1C, RYR2, SCN5A, CASQ2, DSG2, JUP, ANK2, SCN4B
regulation of ion transport (GO:0043269)	-	3.4	0.0	AKAP9, CACNA1C, RYR2, SCN5A, KCNE1, ANK2, HCN4, KCNH2, CASQ2, KCNE3, KCNE2, KCNQ1, CACNB2, NPPA, KCNJ5, SCN4B, SNTA1, KCNJ8, KCNJ2, SCN1B
positive regulation of potassium ion transport (GO:0043268)	-	6.09	0.0	KCNJ2, KCNH2, KCNE1, ANK2, KCNQ1
muscle contraction (GO:0006936)	-	4.37	0.0	CACNA1C, RYR2, SCN5A, SCN4B, NPPA, HCN4, KCNQ1, KCNH2, ANK2, CASQ2, SNTA1, SCN1B
cellular response to purine-containing compound (GO:0071415)	-	7.53	0.036	RYR2, CASQ2
cellular response to organonitrogen compound (GO:0071417)	-	3.87	0.009	CACNA1C, AKAP9, RYR2, CASQ2, HCN4, KCNH2, KCNQ1, JUP, ANK2, KCNE1, KCNJ8
positive regulation of transport (GO:0051050)	-	2.9	0.0	CACNA1C, RYR2, SCN5A, SCN4B, NPPA, KCNQ1, CASQ2, KCNH2, JUP, KCNJ2, CACNB2, ANK2, KCNE1, KCNJ8, SCN1B
regulation of inward rectifier potassium channel activity (GO:1901979)	NEW	9.04	0.017	KCNQ1, KCNE2
sodium ion transport (GO:0006814)	-	4.75	0.0	CACNA1C, RYR2, SCN4B, HCN4, ANK2, SCN5A, SNTA1, SCN1B
cellular response to caffeine (GO:0071313)	-	7.65	0.036	RYR2, CASQ2
sodium ion transmembrane transport (GO:0035725)	-	5.23	0.009	SCN5A, SCN4B, SCN1B, ANK2, HCN4
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	-	6.36	0.025	RYR2, CASQ2, ANK2
negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	NEW	6.59	0.023	CACNA1C, RYR2, CASQ2
regulation of voltage-gated calcium channel activity (GO:1901385)	-	6.59	0.02	CACNA1C, RYR2, NPPA
positive regulation of potassium ion transmembrane transport (GO:1901381)	-	6.43	0.0	KCNJ2, KCNH2, KCNE1, KCNQ1
cardiac conduction (GO:0061337)	-	5.54	0.0	KCNE1, KCNQ1, KCNH2, KCNE2, KCNJ2, JUP, DSG2, ANK2, SCN5A, SCN4B, SCN1B
regulation of metal ion transport (GO:0010959)	-	3.94	0.0	CACNA1C, RYR2, SCN5A, SCN4B, NPPA, KCNH2, KCNE1, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, ANK2, KCNQ1, SNTA1, SCN1B
ion transmembrane transport (GO:0034220)	-	3.08	0.0	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, NPPA, KCNJ5, KCNH2, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
single-organism transport (GO:0044765)	-	2.18	0.0	CACNA1C, RYR2, SCN5A, SCN4B, ANK2, HCN4, KCNE3, KCNE1, CASQ2, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, KCNJ8, SCN1B
single-organism cellular process (GO:0044763)	-	0.65	0.003	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
regulation of muscle system process (GO:0090257)	-	4.51	0.0	CACNA1C, RYR2, SCN5A, NPPA, KCNJ2, ANK2, CASQ2
synaptic transmission (GO:0007268)	-	3.98	0.0	CACNA1C, AKAP9, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNH2, KCNJ2, CACNB2, NPPA, KCNJ5, SNTA1, KCNJ8, SCN1B
cell-cell signaling (GO:0007267)	-	3.35	0.0	CACNA1C, AKAP9, RYR2, CASQ2, ANK2, HCN4, KCNQ1, KCNH2, JUP, KCNJ2, CACNB2, NPPA, KCNJ5, SCN5A, SNTA1, KCNJ8, SCN1B
cell communication (GO:0007154)	-	3.04	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNQ1, KCNH2, JUP, DSG2, KCNJ2, CACNB2, NPPA, KCNJ5, CASQ2, SNTA1, SCN4B, KCNJ8, SCN1B
SA node cell to atrial cardiac muscle cell communication (GO:0086070)	NEW	9.04	0.017	SCN5A, ANK2
cellular localization (GO:0051641)	NEW	2.32	0.049	RYR2, SCN5A, NPPA, KCNH2, KCNQ1, KCNE2, JUP, ANK2, SCN1B
cellular response to oxygen-containing compound (GO:1901701)	-	3.22	0.003	AKAP9, CACNA1C, RYR2, CASQ2, NPPA, HCN4, KCNQ1, KCNH2, TANGO2, JUP, ANK2, KCNE1, KCNJ8
regulation of peptide secretion (GO:0002791)	NEW	4.38	0.002	CACNA1C, RYR2, NPPA, KCNH2, KCNQ1, JUP, ANK2, KCNJ8
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	-	5.44	0.0	CACNA1C, RYR2, CASQ2, ANK2
regulation of calcium ion transport (GO:0051924)	-	4.38	0.002	CACNA1C, CACNB2, CASQ2, RYR2, ANK2
regulation of potassium ion transmembrane transporter activity (GO:1901016)	-	6.02	0.0	RYR2, CASQ2, KCNH2, KCNQ1, KCNE2, ANK2, KCNE1
regulation of ion homeostasis (GO:2000021)	-	4.44	0.003	CACNA1C, RYR2, SCN5A, NPPA, ANK2, CASQ2, SCN1B
cation transmembrane transport (GO:0098655)	-	3.43	0.0	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNE3, KCNE1, KCNQ1, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, SCN1B

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	24	CACNA1C, KCNE1, ANK2, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, NPPA, SCN5A, KCNJ8, SCN1B, AKAP9, LIG3, KCNQ1, DSG2, KCNJ2, SNTA1
membrane part (GO:0044425)	0.95	22	CACNA1C, KCNE1, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN4B, KCNJ8, SCN1B, AKAP9, KCNQ1, DSG2, KCNJ2, SNTA1
membrane (GO:0016020)	0.68	21	CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE1, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, NOS1AP, SCN1B
plasma membrane part (GO:0044459)	1.95	21	CACNA1C, AKAP9, SCN5A, KCNE1, ANK2, HCN4, KCNQ1, NOS1AP, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, CASQ2, SNTA1, SCN4B, KCNJ8, SCN1B
protein complex (GO:0043234)	1.51	20	AKAP9, CACNA1C, RYR2, SCN5A, LIG3, KCNQ1, NOS1AP, CASQ2, KCNH2, JUP, KCNE2, KCNJ2, CACNB2, KCNE3, KCNJ5, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
macromolecular complex (GO:0032991)	1.35	20	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, LIG3, KCNQ1, KCNE1, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, SNTA1, KCNJ8, NOS1AP, SCN1B
plasma membrane (GO:0005886)	1.39	20	CACNA1C, RYR2, KCNE1, ANK2, HCN4, KCNQ1, NOS1AP, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, SCN5A, SNTA1, SCN4B, KCNJ8, SCN1B
intracellular part (GO:0044424)	0.28	19	CACNA1C, AKAP9, RYR2, SCN5A, KCNE1, LIG3, HCN4, KCNQ1, NOS1AP, KCNH2, KCNE3, KCNE2, KCNJ2, JUP, NPPA, ANK2, CASQ2, SNTA1, KCNJ8
membrane protein complex (GO:0098796)	2.84	19	AKAP9, CACNA1C, RYR2, SCN5A, CASQ2, KCNQ1, NOS1AP, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
plasma membrane protein complex (GO:0098797)	3.55	18	AKAP9, CACNA1C, CASQ2, SCN5A, KCNE1, KCNH2, NOS1AP, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
organelle (GO:0043226)	0.4	18	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, NPPA, LIG3, KCNE3, NOS1AP, KCNQ1, KCNE2, KCNJ2, JUP, DSG2, ANK2, KCNE1, SNTA1, KCNJ8
ion channel complex (GO:0034702)	4.18	17	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, KCNQ1, NOS1AP, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
cytoplasmic part (GO:0044444)	0.82	17	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, LIG3, HCN4, KCNQ1, NOS1AP, KCNH2, KCNE2, KCNJ2, JUP, NPPA, ANK2, KCNE1, KCNJ8
transporter complex (GO:1990351)	4.04	17	AKAP9, CACNA1C, RYR2, SCN5A, KCNQ1, NOS1AP, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
transmembrane transporter complex (GO:1902495)	4.06	17	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, KCNQ1, KCNE1, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, SCN4B, KCNJ8, NOS1AP, SCN1B
cation channel complex (GO:0034703)	4.69	17	AKAP9, CACNA1C, RYR2, SCN5A, KCNQ1, NOS1AP, CASQ2, KCNE3, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
integral component of membrane (GO:0016021)	1.14	16	CACNA1C, RYR2, SCN5A, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, KCNE1, SCN4B, KCNJ8, SCN1B
intracellular organelle (GO:0043229)	0.51	16	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, NPPA, LIG3, NOS1AP, KCNQ1, KCNE2, KCNJ2, JUP, ANK2, KCNE1, SNTA1, KCNJ8
intrinsic component of membrane (GO:0031224)	1.13	16	CACNA1C, RYR2, SCN5A, SCN4B, HCN4, KCNQ1, KCNE3, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, KCNE1, KCNJ8, SCN1B
membrane-bounded organelle (GO:0043227)	0.47	15	AKAP9, RYR2, SCN5A, CASQ2, LIG3, KCNE3, NOS1AP, KCNQ1, KCNE2, KCNJ2, JUP, DSG2, NPPA, KCNE1, KCNJ8
intracellular membrane-bounded organelle (GO:0043231)	0.6	13	AKAP9, RYR2, SCN5A, CASQ2, LIG3, NOS1AP, KCNQ1, KCNE2, KCNJ2, JUP, NPPA, KCNE1, KCNJ8
organelle part (GO:0044422)	0.79	11	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, LIG3, NOS1AP, KCNQ1, JUP, ANK2, KCNE1
potassium channel complex (GO:0034705)	5.32	10	AKAP9, KCNE1, KCNQ1, NOS1AP, KCNH2, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNJ8
voltage-gated potassium channel complex (GO:0008076)	5.34	10	AKAP9, KCNE1, KCNH2, NOS1AP, KCNE3, KCNE2, KCNJ2, KCNJ5, KCNQ1, KCNJ8
cytoplasm (GO:0005737)	1.01	9	CACNA1C, AKAP9, CASQ2, NPPA, KCNQ1, KCNE3, JUP, ANK2, SNTA1
Z disc (GO:0030018)	5.11	8	CACNA1C, RYR2, SCN5A, KCNE1, NOS1AP, JUP, ANK2, CASQ2
cell junction (GO:0030054)	2.75	8	SCN5A, DSG2, KCNJ2, JUP, ANK2, SCN4B, SNTA1, SCN1B
contractile fiber part (GO:0044449)	4.53	8	CACNA1C, RYR2, SCN5A, CASQ2, NOS1AP, JUP, ANK2, KCNE1
intracellular organelle part (GO:0044446)	0.81	7	AKAP9, RYR2, CASQ2, LIG3, NOS1AP, KCNQ1, JUP
plasma membrane region (GO:0098590)	2.97	7	SCN5A, NOS1AP, KCNQ1, DSG2, JUP, ANK2, KCNE1
intercalated disc (GO:0014704)	5.93	7	SCN5A, DSG2, KCNJ2, JUP, ANK2, SCN4B, SCN1B
cell-cell contact zone (GO:0044291)	5.69	7	SCN5A, DSG2, KCNJ2, JUP, ANK2, SCN4B, SCN1B
cell-cell junction (GO:0005911)	3.85	7	SCN5A, DSG2, KCNJ2, JUP, ANK2, SCN4B, SCN1B
membrane raft (GO:0045121)	4.18	6	KCNE1, KCNE3, NOS1AP, KCNQ1, ANK2, SCN5A
sarcolemma (GO:0042383)	5.2	6	SCN5A, NOS1AP, CACNB2, ANK2, SNTA1, KCNJ8
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	6	CACNA1C, AKAP9, JUP, ANK2, SNTA1, KCNJ8
T-tubule (GO:0030315)	6.09	6	SCN5A, KCNJ5, NOS1AP, KCNJ2, ANK2, SCN1B
membrane region (GO:0098589)	3.95	6	KCNE1, KCNE3, NOS1AP, KCNQ1, ANK2, SCN5A
intracellular (GO:0005622)	2.37	6	RYR2, SCN5A, KCNH2, ANK2, CASQ2, SNTA1
non-membrane-bounded organelle (GO:0043228)	1.76	6	CACNA1C, AKAP9, JUP, ANK2, SNTA1, KCNJ8
membrane microdomain (GO:0098857)	4.17	6	KCNE1, KCNE3, NOS1AP, KCNQ1, ANK2, SCN5A
neuron part (GO:0097458)	2.64	5	CACNA1C, KCNJ2, KCNE3, SCN1B, ANK2
cell surface (GO:0009986)	3.44	5	SCN5A, KCNE1, KCNE2, DSG2, KCNH2
endoplasmic reticulum (GO:0005783)	2.56	5	KCNJ2, KCNQ1, RYR2, SCN5A, CASQ2
calcium channel complex (GO:0034704)	5.72	5	CACNA1C, CASQ2, CACNB2, RYR2, NOS1AP
vesicle (GO:0031982)	1.64	5	KCNQ1, JUP, KCNE3, RYR2, DSG2
cytoskeleton (GO:0005856)	2.55	4	AKAP9, SNTA1, JUP, ANK2
lytic vacuole (GO:0000323)	3.89	4	KCNQ1, KCNE1, NPPA, KCNE2
organelle membrane (GO:0031090)	1.97	4	KCNQ1, RYR2, CASQ2, NOS1AP
vacuole (GO:0005773)	2.92	4	KCNQ1, KCNE1, NPPA, KCNE2
cytosol (GO:0005829)	1.68	4	AKAP9, JUP, NOS1AP, ANK2
lysosome (GO:0005764)	3.89	4	KCNQ1, KCNE1, NPPA, KCNE2
voltage-gated calcium channel complex (GO:0005891)	6.11	4	CACNA1C, CACNB2, CASQ2, NOS1AP
lateral plasma membrane (GO:0016328)	5.89	4	SNTA1, SCN5A, JUP, DSG2
perinuclear region of cytoplasm (GO:0048471)	3.35	4	NOS1AP, KCNH2, NPPA, HCN4
nucleus (GO:0005634)	1.07	4	JUP, NPPA, NOS1AP, LIG3
intrinsic component of plasma membrane (GO:0031226)	2.53	4	KCNJ2, CACNB2, SCN4B, HCN4
extracellular region part (GO:0044421)	1.57	4	JUP, NPPA, RYR2, DSG2
apical plasma membrane (GO:0016324)	4.13	3	KCNE1, ANK2, DSG2
sarcoplasmic reticulum membrane (GO:0033017)	6.14	3	RYR2, CASQ2, NOS1AP
extracellular vesicle (GO:1903561)	1.89	3	JUP, RYR2, DSG2
extracellular organelle (GO:0043230)	1.89	3	JUP, RYR2, DSG2
extracellular exosome (GO:0070062)	1.89	3	JUP, RYR2, DSG2
L-type voltage-gated calcium channel complex (GO:1990454)	8.01	3	CACNA1C, CACNB2, NOS1AP
endoplasmic reticulum membrane (GO:0005789)	2.95	3	RYR2, CASQ2, NOS1AP
bounding membrane of organelle (GO:0098588)	2.39	3	RYR2, CASQ2, NOS1AP
mitochondrion (GO:0005739)	2.42	3	NOS1AP, KCNJ8, LIG3
membrane-bounded vesicle (GO:0031988)	1.71	3	JUP, RYR2, DSG2
sodium channel complex (GO:0034706)	6.97	3	SCN5A, SCN4B, SCN1B
endoplasmic reticulum part (GO:0044432)	2.73	3	RYR2, CASQ2, NOS1AP
synapse part (GO:0044456)	3.42	3	KCNJ2, CACNA1C, ANK2
nuclear part (GO:0044428)	1.55	3	JUP, NOS1AP, LIG3
neuron projection (GO:0043005)	3.12	3	KCNJ2, KCNE3, ANK2
integral component of plasma membrane (GO:0005887)	2.57	3	KCNJ2, CACNB2, HCN4
cell projection (GO:0042995)	2.47	3	KCNJ2, KCNE3, ANK2
voltage-gated sodium channel complex (GO:0001518)	7.16	3	SCN5A, SCN4B, SCN1B
Golgi apparatus (GO:0005794)	2.7	2	KCNJ2, AKAP9
cell projection part (GO:0044463)	2.97	2	KCNJ2, SCN1B
smooth endoplasmic reticulum (GO:0005790)	6.58	2	KCNJ2, RYR2
anchoring junction (GO:0070161)	3.61	2	JUP, DSG2
dendrite (GO:0030425)	3.92	2	KCNJ2, KCNE3
basolateral plasma membrane (GO:0016323)	4.56	2	KCNQ1, ANK2
caveola (GO:0005901)	5.55	2	NOS1AP, SCN5A
sarcoplasmic reticulum (GO:0016529)	5.81	2	RYR2, CASQ2
cytoskeletal part (GO:0044430)	2.49	2	AKAP9, JUP
side of membrane (GO:0098552)	4.22	2	JUP, KCNJ5
junctional sarcoplasmic reticulum membrane (GO:0014701)	7.5	2	RYR2, CASQ2
extracellular region (GO:0005576)	2.18	2	NPPA, SCN1B
plasma membrane raft (GO:0044853)	5.42	2	NOS1AP, SCN5A
desmosome (GO:0030057)	6.58	2	JUP, DSG2
synapse (GO:0045202)	3.58	2	SNTA1, ANK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
lytic vacuole (GO:0000323)	-	3.89	0.021	KCNQ1, KCNE1, NPPA, KCNE2
integral component of plasma membrane (GO:0005887)	-	2.57	0.0	CACNA1C, AKAP9, RYR2, SCN5A, NPPA, HCN4, KCNQ1, NOS1AP, KCNH2, JUP, KCNJ2, CACNB2, KCNE3, ANK2, SCN1B
sodium channel complex (GO:0034706)	-	6.97	0.001	SCN5A, SCN4B, SCN1B
calcium channel complex (GO:0034704)	-	5.72	0.0	CACNA1C, CACNB2, CASQ2, RYR2
potassium channel complex (GO:0034705)	-	5.32	0.0	AKAP9, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
ion channel complex (GO:0034702)	-	4.18	0.0	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, KCNH2, KCNQ1, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
cation channel complex (GO:0034703)	-	4.69	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, KCNQ1, CASQ2, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
transmembrane transporter complex (GO:1902495)	-	4.06	0.0	CACNA1C, AKAP9, RYR2, SCN5A, CASQ2, ANK2, KCNH2, KCNE1, KCNQ1, KCNE2, KCNJ2, CACNB2, KCNJ5, SCN4B, SNTA1, KCNJ8, SCN1B
intrinsic component of plasma membrane (GO:0031226)	-	2.53	0.001	SCN5A, SCN4B, HCN4, ANK2
desmosome (GO:0030057)	-	6.58	0.048	JUP, DSG2
cell junction (GO:0030054)	-	2.75	0.007	CACNA1C, AKAP9, RYR2, SCN5A, NPPA, NOS1AP, DSG2, KCNJ2, JUP, ANK2, SCN4B, SNTA1, SCN1B
lateral plasma membrane (GO:0016328)	-	5.89	0.046	JUP, SCN5A, DSG2
vacuole (GO:0005773)	-	2.92	0.032	KCNQ1, KCNE1, NPPA, KCNE2
membrane (GO:0016020)	-	0.68	0.014	CACNA1C, RYR2, SCN5A, CASQ2, ANK2, HCN4, KCNQ1, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNH2, KCNE1, SNTA1, KCNJ8
I band (GO:0031674)	NEW	6.67	0.008	CACNA1C, RYR2, CASQ2
neuron part (GO:0097458)	-	2.64	0.0	AKAP9, CACNA1C, RYR2, SCN5A, NPPA, HCN4, KCNQ1, NOS1AP, KCNH2, KCNJ2, JUP, ANK2, SNTA1, KCNJ8, SCN1B
Z disc (GO:0030018)	-	5.11	0.0	CACNA1C, RYR2, SCN5A, CASQ2, KCNH2, KCNQ1, JUP, ANK2, KCNE1
intrinsic component of membrane (GO:0031224)	-	1.13	0.008	KCNJ2, SCN5A, SCN4B, HCN4, ANK2
neuron projection (GO:0043005)	-	3.12	0.007	CACNA1C, RYR2, SCN5A, KCNQ1, NOS1AP, KCNH2, KCNJ2, JUP, ANK2, KCNJ8, SCN1B
plasma membrane part (GO:0044459)	-	1.95	0.0	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN4B, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN5A, KCNJ8, SCN1B, AKAP9, KCNQ1, DSG2, KCNJ2, SNTA1
cell-cell contact zone (GO:0044291)	-	5.69	0.0	RYR2, SCN5A, KCNJ2, JUP, ANK2, SCN4B, SNTA1, SCN1B
sarcoplasmic reticulum lumen (GO:0033018)	NEW	7.72	0.031	RYR2, CASQ2
intercalated disc (GO:0014704)	-	5.93	0.0	RYR2, SCN4B, KCNJ2, JUP, ANK2, SCN5A, SNTA1, SCN1B
sarcolemma (GO:0042383)	-	5.2	0.0	CACNA1C, RYR2, SCN5A, KCNQ1, CACNB2, ANK2, SNTA1, KCNJ8
smooth endoplasmic reticulum (GO:0005790)	-	6.58	0.019	KCNJ2, RYR2
T-tubule (GO:0030315)	-	6.09	0.0	CACNA1C, RYR2, SCN5A, KCNJ2, ANK2, SNTA1, SCN1B
transporter complex (GO:1990351)	-	4.04	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, KCNQ1, CASQ2, KCNH2, KCNE2, KCNJ2, CACNB2, KCNJ5, KCNE1, SNTA1, SCN4B, KCNJ8, SCN1B
cell surface (GO:0009986)	-	3.44	0.005	RYR2, KCNE1, KCNH2, KCNQ1, KCNE2, JUP, DSG2, NPPA, SCN5A, SNTA1
cell body (GO:0044297)	NEW	3.74	0.0	CACNA1C, RYR2, SCN5A, NPPA, KCNQ1, KCNH2, KCNJ2, JUP, ANK2, SNTA1, SCN1B
voltage-gated potassium channel complex (GO:0008076)	-	5.34	0.0	AKAP9, KCNE1, ANK2, KCNQ1, KCNH2, KCNE2, KCNJ2, KCNJ5, KCNJ8
cell-cell junction (GO:0005911)	-	3.85	0.0	AKAP9, SCN5A, NPPA, DSG2, KCNJ2, JUP, ANK2, SCN4B, SNTA1, SCN1B
plasma membrane (GO:0005886)	-	1.39	0.0	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, TANGO2, JUP, KCNE2, ANK2, KCNJ8, SCN1B, AKAP9, KCNQ1, DSG2, KCNJ2, SNTA1
voltage-gated sodium channel complex (GO:0001518)	-	7.16	0.0	SCN5A, SCN4B, SCN1B
protein complex (GO:0043234)	-	1.51	0.0	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN4B, KCNJ8, SCN1B, AKAP9, KCNQ1, KCNJ2, SNTA1
neuromuscular junction (GO:0031594)	NEW	5.81	0.009	SCN5A, SNTA1, KCNQ1, RYR2
macromolecular complex (GO:0032991)	-	1.35	0.0	CACNA1C, KCNE1, NPPA, KCNE3, CASQ2, SCN5A, NOS1AP, CACNB2, KCNJ5, RYR2, HCN4, KCNH2, KCNE2, JUP, ANK2, SCN4B, KCNJ8, SCN1B, AKAP9, KCNQ1, KCNJ2, SNTA1
neuronal cell body (GO:0043025)	NEW	3.9	0.0	CACNA1C, RYR2, SCN5A, NPPA, KCNQ1, KCNH2, KCNJ2, JUP, ANK2, SNTA1, SCN1B
cell projection part (GO:0044463)	-	2.97	0.001	CACNA1C, AKAP9, RYR2, SCN5A, HCN4, KCNH2, KCNQ1, KCNJ2, JUP, ANK2, SNTA1, KCNJ8, SCN1B
lysosome (GO:0005764)	-	3.89	0.02	KCNQ1, KCNE1, NPPA, KCNE2
axon part (GO:0033267)	NEW	4.4	0.001	CACNA1C, SCN5A, HCN4, KCNH2, ANK2, KCNJ8, SCN1B
membrane part (GO:0044425)	-	0.95	0.0	AKAP9, CACNA1C, RYR2, SCN5A, ANK2, HCN4, KCNH2, KCNE1, CASQ2, KCNE3, JUP, KCNE2, KCNJ2, CACNB2, DSG2, KCNJ5, KCNQ1, SNTA1, SCN4B, KCNJ8, SCN1B
contractile fiber part (GO:0044449)	-	4.53	0.0	CACNA1C, RYR2, SCN5A, CASQ2, NPPA, KCNH2, KCNQ1, TANGO2, JUP, ANK2, KCNE1
junctional sarcoplasmic reticulum membrane (GO:0014701)	-	7.5	0.009	RYR2, CASQ2