Gene table of SLC22A4 : solute carrier family 22 member 4

Gene-disease associations table

Disease IDDisease nameSource of annotation with SLC22A4OMIM linkNumber of associated genesgenes
180300RHEUMATOID ARTHRITISClinVar, OMIM link to OMIM 9IL10, PTPN22, SLC22A4, PADI4, HLA-DRB1, NFKBIL1, IRF5, CIITA, CD244

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Annotation of the gene SLC22A4

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation

The gene is in the tandem Group 251, together with the genes:

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Choline metabolism in cancerhsa052316.09
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
SLC-mediated transmembrane transportR-HSA-4254074.95
Organic cation/anion/zwitterion transportR-HSA-5491329.18
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsR-HSA-4253666.34
Transmembrane transport of small moleculesR-HSA-3825513.79
Organic cation transportR-HSA-5491279.81
Associated GO terms for Molecular function
GO termGO IDGO IC
ion antiporter activityGO:00995165.75
purine ribonucleoside triphosphate bindingGO:00356392.22
bindingGO:00054880.18
quaternary ammonium group transmembrane transporter activityGO:00156517.66
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
cation:cation antiporter activityGO:00154916.48
nucleotide bindingGO:00001661.96
organic cation transmembrane transporter activityGO:00151017.34
nucleoside phosphate bindingGO:19012651.96
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
active transmembrane transporter activityGO:00228043.85
antiporter activityGO:00152975.33
secondary active transmembrane transporter activityGO:00152914.29
symporter activityGO:00152934.78
transporter activityGO:00052152.57
cation transmembrane transporter activityGO:00083243.32
solute:cation antiporter activityGO:00152986.24
small molecule bindingGO:00360941.89
PDZ domain bindingGO:00301655.22
protein domain specific bindingGO:00199043.32
amino-acid betaine transmembrane transporter activityGO:00151998.64
substrate-specific transmembrane transporter activityGO:00228912.9
substrate-specific transporter activityGO:00228922.72
carnitine transmembrane transporter activityGO:00152268.64
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
modified amino acid transmembrane transporter activityGO:00723496.97
secondary active organic cation transmembrane transporter activityGO:00085139.05
ion transmembrane transporter activityGO:00150753.04
transmembrane transporter activityGO:00228572.82
adenyl ribonucleotide bindingGO:00325592.41
ATP bindingGO:00055242.43
protein bindingGO:00055150.46
purine ribonucleotide bindingGO:00325552.2
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19