Disease table of RHEUMATOID ARTHRITIS OMIM ID: 180300

Gene-disease associations table

GeneAssociated with RHEUMATOID ARTHRITIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PTPN22ClinVar, OMIM, HUMSAVARHGNC link1p13.23180300, 152700, 222100
SLC22A4ClinVar, OMIMHGNC link5q31.11180300
IRF5ClinVarHGNC link7q32.13612251, 180300, PS266600
IL10OMIMHGNC link1q32.13180300, 614395, 609423
CIITAClinVar, OMIMHGNC link16p13.132209920, 180300
HLA-DRB1OMIMHGNC link6p21.323PS126200, 180300, 181000
CD244ClinVar, OMIMHGNC link1q23.31180300
PADI4OMIMHGNC link1p36.131180300
NFKBIL1ClinVar, OMIMHGNC link6p21.331180300

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
6p212HLA-DRB1, NFKBIL1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22HLA-DRB1, NFKBIL1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2IL10, CD244
1p2PADI4, PTPN22
6p2HLA-DRB1, NFKBIL1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
14IL10, CD244, PADI4, PTPN22
62HLA-DRB1, NFKBIL1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
IRF5YES2TNF, IFNA10
CIITAYES30IRF2, HDAC2, COL1A2, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRA, IL4, HLA-DMA, HLA-C, SIRT1, HLA-DQB1, HLA-B, SLC26A3, HLA-A, PLXNA1, COL1A1, HLA-DMB, HLA-DRB5, S100A4, MMP9, IRF1, PSMC5, HLA-DOB, HLA-DOA, HLA-DPB1, HLA-G, RAB4B, CREBBP, FASLG1HLA-DRB1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12IRF5, IL10
IRF1NO51EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG2CIITA, IL10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SLC22A4YES1RUNX10
IRF5YES2SP1, IRF30
IL10YES23HDAC4, NFATC2, FLI1, PGR, TBX21, REL, SP1, IRF4, CREB1, NR1I2, STAT5A, VDR, HDAC11, ATF1, RELA, PARP1, NFKB1, STAT3, GATA3, CEBPA, IRF1, MSC, CEBPB0
CIITAYES9IRF2, PRDM1, IRF1, USF1, EZH2, STAT1, RFX1, PPARG, MYCN0
HLA-DRB1YES5CIITA, RFXANK, ILF3, RFXAP, RFX51CIITA
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTPN22IRF5No1GRB2
PTPN22HLA-DRB1No1VCP
IRF5CIITANo2HDAC1, EP300
IRF5HLA-DRB1No1TRIM21
IRF5PADI4No1HDAC1
CIITAPADI4No2HDAC1, HDAC2
CIITANFKBIL1No1RFXANK

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTPN22CD244No-1FYN
IRF5IL10No-7IRF4, EGR1, JUN, IL8, IL6, UBC, ICAM1
IRF5PADI4No-1TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Tuberculosishsa051525.173CIITA, HLA-DRB1, IL10
Toxoplasmosishsa051455.713CIITA, HLA-DRB1, IL10
Antigen processing and presentationhsa046126.042CIITA, HLA-DRB1
Systemic lupus erythematosushsa053225.952HLA-DRB1, IL10
Autoimmune thyroid diseasehsa053206.622HLA-DRB1, IL10
Inflammatory bowel disease (IBD)hsa053216.432HLA-DRB1, IL10
Allograft rejectionhsa053306.912HLA-DRB1, IL10
Intestinal immune network for IgA productionhsa046726.792HLA-DRB1, IL10
Leishmaniasishsa051406.322HLA-DRB1, IL10
Epstein-Barr virus infectionhsa051694.972HLA-DRB1, IL10
Asthmahsa053107.342HLA-DRB1, IL10
Influenza Ahsa051645.212CIITA, HLA-DRB1
Staphylococcus aureus infectionhsa051506.642HLA-DRB1, IL10

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen processing and presentation (hsa04612) -6.040.0CIITA, HLA-DRB1, IL10
Allograft rejection (hsa05330) -6.910.001HLA-DRB1, IL10
Graft-versus-host disease (hsa05332) NEW6.840.003HLA-DRB1, IL10
Intestinal immune network for IgA production (hsa04672) -6.790.001HLA-DRB1, IL10
Cell adhesion molecules (CAMs) (hsa04514) NEW5.360.017CIITA, HLA-DRB1, IL10
Immune systemNEW2.920.002IRF5, HLA-DRB1, IL10, CD244, NFKBIL1, CIITA
Asthma (hsa05310) -7.340.001HLA-DRB1, IL10
Type I diabetes mellitus (hsa04940) NEW6.790.007HLA-DRB1, IL10
Viral myocarditis (hsa05416) NEW6.450.012HLA-DRB1, IL10
Leishmaniasis (hsa05140) -6.320.001CIITA, HLA-DRB1, IL10
Epstein-Barr virus infection (hsa05169) -4.970.002CIITA, IRF5, HLA-DRB1, IL10
Toxoplasmosis (hsa05145) -5.710.0CIITA, HLA-DRB1, IL10
Influenza A (hsa05164) -5.210.032CIITA, HLA-DRB1, IL10
Immune diseasesNEW4.470.006CIITA, NFKBIL1, HLA-DRB1, IL10
Inflammatory bowel disease (IBD) (hsa05321) -6.430.0CIITA, HLA-DRB1, IL10
Infectious diseases: BacterialNEW3.760.044CIITA, HLA-DRB1, IL10
Systemic lupus erythematosus (hsa05322) -5.950.007HLA-DRB1, IL10
Autoimmune thyroid disease (hsa05320) -6.620.008HLA-DRB1, IL10
Infectious diseases: ParasiticNEW4.460.007CIITA, HLA-DRB1, IL10
Hematopoietic cell lineage (hsa04640) NEW6.180.046HLA-DRB1, IL10
Staphylococcus aureus infection (hsa05150) -6.640.002HLA-DRB1, IL10
Tuberculosis (hsa05152) -5.170.001CIITA, HLA-DRB1, IL10
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cytokine Signaling in Immune systemR-HSA-12802153.743CIITA, IRF5, HLA-DRB1
Interferon SignalingR-HSA-9135314.953CIITA, IRF5, HLA-DRB1
Interferon gamma signalingR-HSA-8773005.673CIITA, IRF5, HLA-DRB1
Immune SystemR-HSA-1682562.373CIITA, IRF5, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
Immune System (R-HSA-168256) -2.370.0CIITA, CD244, HLA-DRB1, IL10, IRF5
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.0CIITA, IRF5, HLA-DRB1, IL10
Interferon gamma signaling (R-HSA-877300) -5.670.0CIITA, IRF5, HLA-DRB1
MHC class II antigen presentation (R-HSA-2132295) NEW6.010.0CIITA, HLA-DRB1
Interferon Signaling (R-HSA-913531) -4.950.0CIITA, IRF5, HLA-DRB1, IL10
Adaptive Immune System (R-HSA-1280218) NEW3.190.0CIITA, CD244, HLA-DRB1, IL10, IRF5
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
protein binding (GO:0005515) 0.469IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
catalytic activity (GO:0003824) 1.053CIITA, PTPN22, PADI4
heterocyclic compound binding (GO:1901363) 1.063CIITA, IRF5, SLC22A4
organic cyclic compound binding (GO:0097159) 1.053CIITA, IRF5, SLC22A4
purine ribonucleoside triphosphate binding (GO:0035639) 2.222CIITA, SLC22A4
molecular transducer activity (GO:0060089) 2.322CD244, HLA-DRB1
macromolecular complex binding (GO:0044877) 2.612CIITA, HLA-DRB1
receptor activity (GO:0004872) 2.322CD244, HLA-DRB1
nucleic acid binding (GO:0003676) 1.442CIITA, IRF5
DNA binding (GO:0003677) 1.922CIITA, IRF5
nucleoside phosphate binding (GO:1901265) 1.962CIITA, SLC22A4
nucleoside binding (GO:0001882) 2.212CIITA, SLC22A4
nucleotide binding (GO:0000166) 1.962CIITA, SLC22A4
purine nucleoside binding (GO:0001883) 2.222CIITA, SLC22A4
ribonucleoside binding (GO:0032549) 2.222CIITA, SLC22A4
protein complex binding (GO:0032403) 3.092CIITA, HLA-DRB1
purine nucleotide binding (GO:0017076) 2.192CIITA, SLC22A4
ATP binding (GO:0005524) 2.432CIITA, SLC22A4
hydrolase activity (GO:0016787) 1.92PTPN22, PADI4
regulatory region nucleic acid binding (GO:0001067) 3.032CIITA, IRF5
small molecule binding (GO:0036094) 1.892CIITA, SLC22A4
protein domain specific binding (GO:0019904) 3.322PTPN22, SLC22A4
adenyl nucleotide binding (GO:0030554) 2.42CIITA, SLC22A4
carbohydrate derivative binding (GO:0097367) 2.032CIITA, SLC22A4
adenyl ribonucleotide binding (GO:0032559) 2.412CIITA, SLC22A4
regulatory region DNA binding (GO:0000975) 3.032CIITA, IRF5
purine ribonucleotide binding (GO:0032555) 2.22CIITA, SLC22A4
receptor binding (GO:0005102) 2.432CD244, IL10
purine ribonucleoside binding (GO:0032550) 2.222CIITA, SLC22A4
ribonucleotide binding (GO:0032553) 2.192CIITA, SLC22A4

NET-GE enrichment

Term New enriched termICP valueGenes
peptide binding (GO:0042277) NEW4.220.0HLA-DRB1, IL10
peptide antigen binding (GO:0042605) NEW6.180.0HLA-DRB1, IL10
amide binding (GO:0033218) NEW4.140.0HLA-DRB1, IL10
antigen binding (GO:0003823) NEW5.020.0HLA-DRB1, IL10
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.269IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
biological regulation (GO:0065007) 0.399IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
response to stimulus (GO:0050896) 1.228IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
regulation of biological process (GO:0050789) 0.458IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
regulation of cellular process (GO:0050794) 0.58IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
regulation of primary metabolic process (GO:0080090) 1.087IRF5, CD244, IL10, PTPN22, PADI4, NFKBIL1, CIITA
regulation of metabolic process (GO:0019222) 1.027IRF5, CD244, IL10, PTPN22, PADI4, NFKBIL1, CIITA
regulation of cellular metabolic process (GO:0031323) 1.077IRF5, CD244, IL10, PTPN22, PADI4, NFKBIL1, CIITA
immune system process (GO:0002376) 2.297IRF5, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
regulation of multicellular organismal process (GO:0051239) 1.877IRF5, NFKBIL1, CD244, IL10, PTPN22, HLA-DRB1, CIITA
single-organism process (GO:0044699) 0.487CD244, IL10, PTPN22, PADI4, NFKBIL1, CIITA, SLC22A4
organic substance metabolic process (GO:0071704) 0.636IRF5, IL10, PTPN22, PADI4, CIITA, SLC22A4
regulation of macromolecule metabolic process (GO:0060255) 1.086IRF5, IL10, PTPN22, PADI4, NFKBIL1, CIITA
regulation of cellular biosynthetic process (GO:0031326) 1.386IRF5, IL10, CD244, PADI4, NFKBIL1, CIITA
regulation of biosynthetic process (GO:0009889) 1.376IRF5, IL10, CD244, PADI4, NFKBIL1, CIITA
cellular metabolic process (GO:0044237) 0.696IRF5, IL10, PTPN22, PADI4, CIITA, SLC22A4
defense response (GO:0006952) 2.786IRF5, IL10, CD244, PADI4, HLA-DRB1, CIITA
regulation of cytokine production (GO:0001817) 3.46IRF5, NFKBIL1, CD244, IL10, PTPN22, HLA-DRB1
response to stress (GO:0006950) 1.86IRF5, IL10, CD244, PADI4, HLA-DRB1, CIITA
single-organism cellular process (GO:0044763) 0.656CD244, IL10, PTPN22, PADI4, NFKBIL1, SLC22A4
signal transduction (GO:0007165) 1.286IRF5, HLA-DRB1, CD244, PTPN22, NFKBIL1, CIITA
metabolic process (GO:0008152) 0.586IRF5, IL10, PTPN22, PADI4, CIITA, SLC22A4
immune response (GO:0006955) 2.866IRF5, IL10, CD244, PADI4, HLA-DRB1, CIITA
positive regulation of biological process (GO:0048518) 1.26IRF5, CD244, IL10, PTPN22, HLA-DRB1, CIITA
regulation of gene expression (GO:0010468) 1.376IRF5, IL10, PTPN22, PADI4, NFKBIL1, CIITA
positive regulation of cellular process (GO:0048522) 1.36IRF5, CD244, IL10, PTPN22, HLA-DRB1, CIITA
positive regulation of metabolic process (GO:0009893) 1.745CIITA, PTPN22, CD244, IL10, IRF5
regulation of transport (GO:0051049) 2.245HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
positive regulation of cellular metabolic process (GO:0031325) 1.815CIITA, CD244, PTPN22, IL10, IRF5
regulation of protein transport (GO:0051223) 3.125HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
regulation of protein localization (GO:0032880) 2.885HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
response to external biotic stimulus (GO:0043207) 3.135NFKBIL1, PTPN22, HLA-DRB1, IL10, IRF5
negative regulation of multicellular organismal process (GO:0051241) 2.845CIITA, NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465CIITA, IRF5, PADI4, NFKBIL1, IL10
regulation of immune system process (GO:0002682) 2.55HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
negative regulation of biological process (GO:0048519) 1.335CIITA, NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of establishment of protein localization (GO:0070201) 3.025HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435CIITA, IRF5, PADI4, NFKBIL1, IL10
regulation of nucleic acid-templated transcription (GO:1903506) 1.555CIITA, IRF5, PADI4, NFKBIL1, IL10
regulation of nitrogen compound metabolic process (GO:0051171) 1.365CIITA, IRF5, PADI4, NFKBIL1, IL10
regulation of RNA biosynthetic process (GO:2001141) 1.555CIITA, IRF5, PADI4, NFKBIL1, IL10
response to chemical (GO:0042221) 1.985CIITA, PTPN22, NFKBIL1, IL10, IRF5
regulation of localization (GO:0032879) 1.945HLA-DRB1, NFKBIL1, PTPN22, CD244, IL10
response to organic substance (GO:0010033) 2.25CIITA, PTPN22, NFKBIL1, IL10, IRF5
primary metabolic process (GO:0044238) 0.695CIITA, PTPN22, PADI4, IRF5, SLC22A4
response to biotic stimulus (GO:0009607) 3.095NFKBIL1, PTPN22, HLA-DRB1, IL10, IRF5
cellular macromolecule metabolic process (GO:0044260) 0.935CIITA, PTPN22, PADI4, IRF5, IL10
response to external stimulus (GO:0009605) 2.555NFKBIL1, PTPN22, HLA-DRB1, IL10, IRF5
regulation of RNA metabolic process (GO:0051252) 1.525CIITA, IRF5, PADI4, NFKBIL1, IL10
macromolecule metabolic process (GO:0043170) 0.835CIITA, PTPN22, PADI4, IRF5, IL10
regulation of transcription, DNA-templated (GO:0006355) 1.565CIITA, IRF5, PADI4, NFKBIL1, IL10
regulation of macromolecule biosynthetic process (GO:0010556) 1.435CIITA, IRF5, PADI4, NFKBIL1, IL10
negative regulation of cellular process (GO:0048523) 1.415CIITA, NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of cytokine secretion (GO:0050707) 4.744CD244, PTPN22, HLA-DRB1, IL10
regulation of mononuclear cell proliferation (GO:0032944) 4.454CD244, PTPN22, HLA-DRB1, IL10
cell surface receptor signaling pathway (GO:0007166) 2.094CIITA, PTPN22, IRF5, HLA-DRB1
regulation of cellular localization (GO:0060341) 3.034NFKBIL1, PTPN22, HLA-DRB1, IL10
positive regulation of biosynthetic process (GO:0009891) 2.294CIITA, CD244, IRF5, IL10
regulation of cell activation (GO:0050865) 3.534HLA-DRB1, PTPN22, CD244, IL10
negative regulation of response to stimulus (GO:0048585) 2.524NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of signaling (GO:0023051) 1.724NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of response to stimulus (GO:0048583) 1.544NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of T cell activation (GO:0050863) 4.054CD244, IL10, PTPN22, HLA-DRB1
regulation of cell-cell adhesion (GO:0022407) 3.794HLA-DRB1, PTPN22, CD244, IL10
cellular nitrogen compound metabolic process (GO:0034641) 1.224CIITA, IRF5, PADI4, SLC22A4
positive regulation of gene expression (GO:0010628) 2.354CIITA, PTPN22, IRF5, IL10
positive regulation of cellular biosynthetic process (GO:0031328) 2.34CIITA, CD244, IRF5, IL10
regulation of secretion by cell (GO:1903530) 3.284PTPN22, IL10, CD244, HLA-DRB1
cellular response to chemical stimulus (GO:0070887) 2.574CIITA, PTPN22, NFKBIL1, IL10
positive regulation of secretion by cell (GO:1903532) 3.934CD244, PTPN22, HLA-DRB1, IL10
positive regulation of protein transport (GO:0051222) 3.614HLA-DRB1, PTPN22, CD244, IL10
regulation of cell communication (GO:0010646) 1.734NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of defense response (GO:0031347) 3.114NFKBIL1, PTPN22, HLA-DRB1, IL10
organic substance biosynthetic process (GO:1901576) 1.344CIITA, IRF5, PADI4, IL10
cellular response to stimulus (GO:0051716) 1.974CIITA, PTPN22, NFKBIL1, IL10
regulation of lymphocyte activation (GO:0051249) 3.734HLA-DRB1, PTPN22, CD244, IL10
regulation of protein secretion (GO:0050708) 3.774CD244, PTPN22, HLA-DRB1, IL10
regulation of secretion (GO:0051046) 3.24CD244, PTPN22, HLA-DRB1, IL10
positive regulation of multicellular organismal process (GO:0051240) 2.494PTPN22, CD244, IL10, IRF5
positive regulation of secretion (GO:0051047) 3.854HLA-DRB1, PTPN22, CD244, IL10
regulation of leukocyte proliferation (GO:0070663) 4.44HLA-DRB1, PTPN22, CD244, IL10
regulation of response to external stimulus (GO:0032101) 3.064NFKBIL1, PTPN22, HLA-DRB1, IL10
cellular response to organic substance (GO:0071310) 2.784CIITA, PTPN22, NFKBIL1, IL10
negative regulation of immune system process (GO:0002683) 3.854NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of biological quality (GO:0065008) 1.684HLA-DRB1, NFKBIL1, IL10, SLC22A4
regulation of cell adhesion (GO:0030155) 3.274HLA-DRB1, PTPN22, CD244, IL10
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.014CD244, PTPN22, HLA-DRB1, IL10
regulation of cell proliferation (GO:0042127) 2.414CD244, PTPN22, HLA-DRB1, IL10
positive regulation of transport (GO:0051050) 2.94HLA-DRB1, PTPN22, CD244, IL10
regulation of interferon-gamma production (GO:0032649) 5.214HLA-DRB1, PTPN22, CD244, IL10
regulation of T cell proliferation (GO:0042129) 4.744HLA-DRB1, PTPN22, CD244, IL10
biosynthetic process (GO:0009058) 1.324CIITA, IRF5, PADI4, IL10
macromolecule biosynthetic process (GO:0009059) 1.614CIITA, IRF5, PADI4, IL10
positive regulation of establishment of protein localization (GO:1904951) 3.494CD244, IL10, PTPN22, HLA-DRB1
positive regulation of macromolecule metabolic process (GO:0010604) 1.814CIITA, PTPN22, IRF5, IL10
response to oxygen-containing compound (GO:1901700) 2.574PTPN22, NFKBIL1, IL10, IRF5
regulation of immune response (GO:0050776) 2.984NFKBIL1, PTPN22, HLA-DRB1, IL10
positive regulation of protein secretion (GO:0050714) 4.394CD244, PTPN22, HLA-DRB1, IL10
regulation of response to stress (GO:0080134) 2.534NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of lymphocyte proliferation (GO:0050670) 4.464HLA-DRB1, PTPN22, CD244, IL10
regulation of leukocyte activation (GO:0002694) 3.64CD244, IL10, PTPN22, HLA-DRB1
nitrogen compound metabolic process (GO:0006807) 1.134CIITA, IRF5, PADI4, SLC22A4
response to molecule of bacterial origin (GO:0002237) 3.994NFKBIL1, PTPN22, IRF5, IL10
response to nitrogen compound (GO:1901698) 3.124CIITA, PTPN22, IRF5, IL10
negative regulation of cytokine production (GO:0001818) 4.44NFKBIL1, PTPN22, HLA-DRB1, IL10
positive regulation of cytokine production (GO:0001819) 3.824CD244, PTPN22, IL10, IRF5
regulation of intracellular protein transport (GO:0033157) 3.83PTPN22, NFKBIL1, IL10
cytokine-mediated signaling pathway (GO:0019221) 3.63CIITA, IRF5, HLA-DRB1
regulation of intracellular transport (GO:0032386) 3.583PTPN22, NFKBIL1, IL10
positive regulation of response to stimulus (GO:0048584) 2.183PTPN22, HLA-DRB1, IL10
negative regulation of cell adhesion (GO:0007162) 4.333PTPN22, HLA-DRB1, IL10
regulation of production of molecular mediator of immune response (GO:0002700) 5.13PTPN22, CD244, IL10
organic cyclic compound biosynthetic process (GO:1901362) 1.663CIITA, IRF5, PADI4
organic cyclic compound metabolic process (GO:1901360) 1.263CIITA, IRF5, PADI4
negative regulation of macromolecule metabolic process (GO:0010605) 2.013CIITA, PTPN22, IL10
negative regulation of signal transduction (GO:0009968) 2.753PTPN22, NFKBIL1, IL10
positive regulation of cell adhesion (GO:0045785) 3.793CD244, PTPN22, HLA-DRB1
regulation of signal transduction (GO:0009966) 1.843PTPN22, NFKBIL1, IL10
negative regulation of molecular function (GO:0044092) 2.743PTPN22, NFKBIL1, IL10
heterocycle metabolic process (GO:0046483) 1.313CIITA, IRF5, PADI4
negative regulation of tumor necrosis factor production (GO:0032720) 5.993PTPN22, NFKBIL1, IL10
negative regulation of transport (GO:0051051) 3.63PTPN22, NFKBIL1, IL10
lymphocyte activation (GO:0046649) 3.963CD244, PTPN22, IL10
response to other organism (GO:0051707) 3.483IRF5, HLA-DRB1, IL10
regulation of transcription factor import into nucleus (GO:0042990) 5.163PTPN22, NFKBIL1, IL10
multi-organism process (GO:0051704) 2.653IRF5, HLA-DRB1, IL10
positive regulation of signaling (GO:0023056) 2.413PTPN22, HLA-DRB1, IL10
negative regulation of signaling (GO:0023057) 2.653PTPN22, NFKBIL1, IL10
response to organonitrogen compound (GO:0010243) 3.23PTPN22, IRF5, IL10
regulation of protein import (GO:1904589) 4.523PTPN22, NFKBIL1, IL10
aromatic compound biosynthetic process (GO:0019438) 1.73CIITA, IRF5, PADI4
regulation of interferon-alpha production (GO:0032647) 6.733PTPN22, IRF5, IL10
negative regulation of metabolic process (GO:0009892) 1.933CIITA, PTPN22, IL10
regulation of protein targeting (GO:1903533) 4.03PTPN22, NFKBIL1, IL10
leukocyte activation (GO:0045321) 3.763PTPN22, CD244, IL10
negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) 5.943PTPN22, NFKBIL1, IL10
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 5.13PTPN22, NFKBIL1, IL10
response to lipopolysaccharide (GO:0032496) 4.033PTPN22, NFKBIL1, IL10
negative regulation of protein transport (GO:0051224) 4.443PTPN22, NFKBIL1, IL10
positive regulation of cell communication (GO:0010647) 2.413PTPN22, HLA-DRB1, IL10
nucleic acid-templated transcription (GO:0097659) 1.913CIITA, IRF5, PADI4
positive regulation of immune system process (GO:0002684) 2.963CD244, PTPN22, HLA-DRB1
regulation of molecular function (GO:0065009) 1.783PTPN22, NFKBIL1, IL10
heterocycle biosynthetic process (GO:0018130) 1.73CIITA, IRF5, PADI4
regulation of multi-organism process (GO:0043900) 3.63PTPN22, NFKBIL1, IL10
inflammatory response (GO:0006954) 3.643CIITA, HLA-DRB1, IL10
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723CIITA, IRF5, PADI4
regulation of protein import into nucleus (GO:0042306) 4.543PTPN22, NFKBIL1, IL10
RNA metabolic process (GO:0016070) 1.593CIITA, IRF5, PADI4
regulation of protein localization to nucleus (GO:1900180) 4.343PTPN22, NFKBIL1, IL10
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593CIITA, IRF5, PADI4
positive regulation of cytokine secretion (GO:0050715) 5.163PTPN22, CD244, IL10
cell activation (GO:0001775) 3.473PTPN22, CD244, IL10
negative regulation of leukocyte activation (GO:0002695) 4.793PTPN22, HLA-DRB1, IL10
regulation of immune effector process (GO:0002697) 3.713CD244, PTPN22, IL10
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243CIITA, IRF5, IL10
regulation of nucleocytoplasmic transport (GO:0046822) 4.333PTPN22, NFKBIL1, IL10
transcription, DNA-templated (GO:0006351) 1.913CIITA, IRF5, PADI4
negative regulation of response to external stimulus (GO:0032102) 4.183NFKBIL1, HLA-DRB1, IL10
RNA biosynthetic process (GO:0032774) 1.843CIITA, IRF5, PADI4
regulation of cellular protein localization (GO:1903827) 3.433PTPN22, NFKBIL1, IL10
cellular biosynthetic process (GO:0044249) 1.373CIITA, IRF5, PADI4
negative regulation of cell communication (GO:0010648) 2.663PTPN22, NFKBIL1, IL10
cellular macromolecule biosynthetic process (GO:0034645) 1.663CIITA, IRF5, PADI4
negative regulation of establishment of protein localization (GO:1904950) 4.393PTPN22, NFKBIL1, IL10
response to endogenous stimulus (GO:0009719) 2.793PTPN22, IRF5, IL10
nucleobase-containing compound metabolic process (GO:0006139) 1.353CIITA, IRF5, PADI4
negative regulation of leukocyte cell-cell adhesion (GO:1903038) 5.193PTPN22, HLA-DRB1, IL10
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.353CD244, PTPN22, HLA-DRB1
regulation of interleukin-8 production (GO:0032677) 5.623PTPN22, CD244, IL10
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563CIITA, IRF5, IL10
negative regulation of cellular metabolic process (GO:0031324) 2.013CIITA, PTPN22, IL10
cellular aromatic compound metabolic process (GO:0006725) 1.33CIITA, IRF5, PADI4
positive regulation of T cell activation (GO:0050870) 4.393PTPN22, CD244, HLA-DRB1
positive regulation of transcription, DNA-templated (GO:0045893) 2.563CIITA, IRF5, IL10
positive regulation of lymphocyte activation (GO:0051251) 4.073PTPN22, CD244, HLA-DRB1
negative regulation of lymphocyte activation (GO:0051250) 4.953PTPN22, HLA-DRB1, IL10
positive regulation of RNA metabolic process (GO:0051254) 2.513CIITA, IRF5, IL10
positive regulation of RNA biosynthetic process (GO:1902680) 2.543CIITA, IRF5, IL10
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813CIITA, IRF5, IL10
regulation of type I interferon production (GO:0032479) 5.033PTPN22, IRF5, IL10
developmental process (GO:0032502) 1.363CIITA, PADI4, IL10
negative regulation of T cell activation (GO:0050868) 5.263PTPN22, HLA-DRB1, IL10
positive regulation of cell activation (GO:0050867) 3.973CD244, PTPN22, HLA-DRB1
negative regulation of cell activation (GO:0050866) 4.673PTPN22, HLA-DRB1, IL10
nucleic acid metabolic process (GO:0090304) 1.463CIITA, IRF5, PADI4
negative regulation of cell-cell adhesion (GO:0022408) 4.843PTPN22, HLA-DRB1, IL10
positive regulation of cell-cell adhesion (GO:0022409) 4.233CD244, PTPN22, HLA-DRB1
response to lipid (GO:0033993) 3.113PTPN22, NFKBIL1, IL10
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393CIITA, IRF5, IL10
positive regulation of leukocyte activation (GO:0002696) 4.03CD244, PTPN22, HLA-DRB1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353CIITA, IRF5, IL10
innate immune response (GO:0045087) 3.553CD244, PADI4, IRF5
single-organism developmental process (GO:0044767) 1.493CIITA, PADI4, IL10
interferon-gamma-mediated signaling pathway (GO:0060333) 5.483CIITA, IRF5, HLA-DRB1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293CIITA, IRF5, IL10
localization (GO:0051179) 1.43NFKBIL1, SLC22A4, IL10
single-organism localization (GO:1902578) 2.093NFKBIL1, SLC22A4, IL10
cellular response to oxygen-containing compound (GO:1901701) 3.223PTPN22, NFKBIL1, IL10
regulation of tumor necrosis factor production (GO:0032680) 5.133PTPN22, NFKBIL1, IL10
response to peptide (GO:1901652) 3.943PTPN22, IRF5, IL10
immune effector process (GO:0002252) 3.583CD244, IRF5, HLA-DRB1
negative regulation of T cell proliferation (GO:0042130) 5.822HLA-DRB1, IL10
regulation of phosphate metabolic process (GO:0019220) 2.352CD244, PTPN22
negative regulation of secretion (GO:0051048) 4.442PTPN22, IL10
positive regulation of alpha-beta T cell activation (GO:0046635) 5.762PTPN22, CD244
negative regulation of intracellular transport (GO:0032387) 5.022NFKBIL1, IL10
negative regulation of defense response (GO:0031348) 4.752HLA-DRB1, IL10
positive regulation of production of molecular mediator of immune response (GO:0002702) 5.552PTPN22, CD244
maintenance of location in cell (GO:0051651) 5.132NFKBIL1, IL10
regulation of alpha-beta T cell proliferation (GO:0046640) 6.512CD244, PTPN22
cellular component organization or biogenesis (GO:0071840) 1.222PADI4, HLA-DRB1
single-organism metabolic process (GO:0044710) 1.632PADI4, SLC22A4
cellular developmental process (GO:0048869) 1.822PTPN22, IL10
response to bacterium (GO:0009617) 4.182HLA-DRB1, IL10
regulation of inflammatory response (GO:0050727) 4.032HLA-DRB1, IL10
interspecies interaction between organisms (GO:0044419) 3.082IRF5, HLA-DRB1
negative regulation of protein import (GO:1904590) 5.62NFKBIL1, IL10
positive regulation of interferon-beta production (GO:0032728) 6.292PTPN22, IRF5
positive regulation of interferon-gamma production (GO:0032729) 5.592CD244, PTPN22
positive regulation of interferon-alpha production (GO:0032727) 6.92PTPN22, IRF5
regulation of interferon-gamma secretion (GO:1902713) 7.432CD244, PTPN22
regulation of interleukin-12 production (GO:0032655) 5.782IRF5, IL10
positive regulation of interferon-gamma secretion (GO:1902715) 7.782CD244, PTPN22
regulation of interleukin-8 secretion (GO:2000482) 6.782CD244, PTPN22
negative regulation of cellular protein metabolic process (GO:0032269) 2.882PTPN22, IL10
maintenance of protein location (GO:0045185) 5.212NFKBIL1, IL10
regulation of cellular protein metabolic process (GO:0032268) 1.992PTPN22, IL10
cytoplasmic sequestering of transcription factor (GO:0042994) 6.782NFKBIL1, IL10
positive regulation of alpha-beta T cell proliferation (GO:0046641) 6.682PTPN22, CD244
negative regulation of transcription factor import into nucleus (GO:0042992) 6.072NFKBIL1, IL10
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062PTPN22, HLA-DRB1
organonitrogen compound metabolic process (GO:1901564) 2.322PADI4, SLC22A4
single-multicellular organism process (GO:0044707) 1.782PADI4, IL10
cell motility (GO:0048870) 3.022CD244, IL10
protein metabolic process (GO:0019538) 1.452PTPN22, PADI4
cellular component assembly (GO:0022607) 2.142PADI4, HLA-DRB1
negative regulation of biosynthetic process (GO:0009890) 2.472CIITA, IL10
regulation of response to biotic stimulus (GO:0002831) 4.32PTPN22, NFKBIL1
regulation of interferon-beta production (GO:0032648) 5.922PTPN22, IRF5
movement of cell or subcellular component (GO:0006928) 2.612CD244, IL10
negative regulation of gene expression (GO:0010629) 2.482CIITA, PTPN22
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842CD244, PTPN22
negative regulation of mononuclear cell proliferation (GO:0032945) 5.592HLA-DRB1, IL10
cytoplasmic sequestering of protein (GO:0051220) 6.042NFKBIL1, IL10
response to muramyl dipeptide (GO:0032495) 7.092PTPN22, IRF5
regulation of apoptotic process (GO:0042981) 2.52IRF5, IL10
cellular protein metabolic process (GO:0044267) 1.632PTPN22, PADI4
immune response-regulating signaling pathway (GO:0002764) 3.722PTPN22, HLA-DRB1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962PTPN22, HLA-DRB1
cellular component organization (GO:0016043) 1.242PADI4, HLA-DRB1
macromolecular complex assembly (GO:0065003) 2.552PADI4, HLA-DRB1
positive regulation of granzyme B production (GO:0071663) 8.632CD244, PTPN22
cellular response to molecule of bacterial origin (GO:0071219) 4.882NFKBIL1, IL10
regulation of granzyme B production (GO:0071661) 8.632CD244, PTPN22
cellular response to biotic stimulus (GO:0071216) 4.762NFKBIL1, IL10
cell migration (GO:0016477) 3.122CD244, IL10
regulation of natural killer cell activation (GO:0032814) 6.42PTPN22, CD244
regulation of natural killer cell proliferation (GO:0032817) 7.532CD244, PTPN22
negative regulation of inflammatory response (GO:0050728) 5.112HLA-DRB1, IL10
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822PTPN22, IL10
macromolecule modification (GO:0043412) 1.732PTPN22, PADI4
negative regulation of multi-organism process (GO:0043901) 4.72NFKBIL1, IL10
negative regulation of protein import into nucleus (GO:0042308) 5.62NFKBIL1, IL10
negative regulation of intracellular signal transduction (GO:1902532) 3.632PTPN22, IL10
positive regulation of intracellular signal transduction (GO:1902533) 2.952PTPN22, IL10
maintenance of location (GO:0051235) 4.772NFKBIL1, IL10
regulation of intracellular signal transduction (GO:1902531) 2.312PTPN22, IL10
leukocyte differentiation (GO:0002521) 4.132PTPN22, IL10
negative regulation of protein localization to nucleus (GO:1900181) 5.492NFKBIL1, IL10
negative regulation of cytokine secretion (GO:0050710) 5.922PTPN22, IL10
cellular response to nitrogen compound (GO:1901699) 3.792CIITA, PTPN22
positive regulation of type I interferon production (GO:0032481) 5.482PTPN22, IRF5
negative regulation of interleukin-8 production (GO:0032717) 7.022PTPN22, IL10
negative regulation of interleukin-6 production (GO:0032715) 6.172PTPN22, IL10
protein modification process (GO:0036211) 1.792PTPN22, PADI4
negative regulation of nucleocytoplasmic transport (GO:0046823) 5.472NFKBIL1, IL10
positive regulation of signal transduction (GO:0009967) 2.52PTPN22, IL10
positive regulation of immune effector process (GO:0002699) 4.692PTPN22, CD244
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532CIITA, IL10
cell differentiation (GO:0030154) 2.142PTPN22, IL10
negative regulation of secretion by cell (GO:1903531) 4.552PTPN22, IL10
response to organic cyclic compound (GO:0014070) 3.072CIITA, IL10
negative regulation of cellular protein localization (GO:1903828) 4.822NFKBIL1, IL10
negative regulation of protein metabolic process (GO:0051248) 2.822PTPN22, IL10
regulation of MHC class II biosynthetic process (GO:0045346) 7.162CIITA, IL10
positive regulation of phosphorus metabolic process (GO:0010562) 2.782PTPN22, CD244
regulation of protein metabolic process (GO:0051246) 1.932PTPN22, IL10
negative regulation of cellular biosynthetic process (GO:0031327) 2.492CIITA, IL10
regulation of interleukin-6 production (GO:0032675) 5.082PTPN22, IL10
positive regulation of cell proliferation (GO:0008284) 3.012PTPN22, CD244
negative regulation of cell proliferation (GO:0008285) 3.262HLA-DRB1, IL10
multicellular organismal process (GO:0032501) 1.452PADI4, IL10
positive regulation of CD8-positive, alpha-beta T cell activation (GO:2001187) 7.942CD244, PTPN22
regulation of CD8-positive, alpha-beta T cell activation (GO:2001185) 7.532PTPN22, CD244
cellular response to lipid (GO:0071396) 3.962NFKBIL1, IL10
regulation of toll-like receptor signaling pathway (GO:0034121) 5.882PTPN22, NFKBIL1
negative regulation of inflammatory response to antigenic stimulus (GO:0002862) 7.432HLA-DRB1, IL10
immune response-activating signal transduction (GO:0002757) 3.82PTPN22, HLA-DRB1
defense response to other organism (GO:0098542) 3.752IRF5, IL10
viral process (GO:0016032) 3.152IRF5, HLA-DRB1
positive regulation of MHC class II biosynthetic process (GO:0045348) 7.652CIITA, IL10
negative regulation of immune response (GO:0050777) 4.942HLA-DRB1, IL10
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832NFKBIL1, IL10
aging (GO:0007568) 4.162CIITA, IL10
positive regulation of lymphocyte proliferation (GO:0050671) 4.852PTPN22, CD244
cellular response to organic cyclic compound (GO:0071407) 3.932CIITA, IL10
positive regulation of immune response (GO:0050778) 3.42PTPN22, HLA-DRB1
negative regulation of lymphocyte proliferation (GO:0050672) 5.592HLA-DRB1, IL10
lymphocyte differentiation (GO:0030098) 4.492PTPN22, IL10
positive regulation of CD8-positive, alpha-beta T cell proliferation (GO:2000566) 8.122CD244, PTPN22
regulation of CD8-positive, alpha-beta T cell proliferation (GO:2000564) 7.942PTPN22, CD244
cellular response to lipopolysaccharide (GO:0071222) 4.942NFKBIL1, IL10
macromolecular complex subunit organization (GO:0043933) 2.142PADI4, HLA-DRB1
leukocyte migration (GO:0050900) 4.192CD244, IL10
cellular macromolecular complex assembly (GO:0034622) 3.182PADI4, HLA-DRB1
positive regulation of cell death (GO:0010942) 3.322IRF5, IL10
regulation of cell death (GO:0010941) 2.432IRF5, IL10
maintenance of protein location in cell (GO:0032507) 5.272NFKBIL1, IL10
protein complex subunit organization (GO:0071822) 2.62PADI4, HLA-DRB1
positive regulation of apoptotic process (GO:0043065) 3.382IRF5, IL10
regulation of programmed cell death (GO:0043067) 2.492IRF5, IL10
positive regulation of leukocyte proliferation (GO:0070665) 4.792PTPN22, CD244
negative regulation of leukocyte proliferation (GO:0070664) 5.522HLA-DRB1, IL10
positive regulation of programmed cell death (GO:0043068) 3.382IRF5, IL10
regulation of alpha-beta T cell activation (GO:0046634) 5.482CD244, PTPN22
antigen receptor-mediated signaling pathway (GO:0050851) 4.432PTPN22, HLA-DRB1
T cell receptor signaling pathway (GO:0050852) 4.712PTPN22, HLA-DRB1
regulation of innate immune response (GO:0045088) 3.862PTPN22, NFKBIL1
positive regulation of phosphate metabolic process (GO:0045937) 2.782CD244, PTPN22
protein complex assembly (GO:0006461) 2.782PADI4, HLA-DRB1
negative regulation of intracellular protein transport (GO:0090317) 5.232NFKBIL1, IL10
cellular protein modification process (GO:0006464) 1.792PTPN22, PADI4
positive regulation of T cell proliferation (GO:0042102) 5.162CD244, PTPN22
regulation of phosphorus metabolic process (GO:0051174) 2.352CD244, PTPN22
multi-organism cellular process (GO:0044764) 3.142IRF5, HLA-DRB1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472CIITA, IL10
negative regulation of protein secretion (GO:0050709) 5.062PTPN22, IL10
locomotion (GO:0040011) 2.912CD244, IL10
phosphate-containing compound metabolic process (GO:0006796) 2.162CIITA, PTPN22
regulation of inflammatory response to antigenic stimulus (GO:0002861) 6.732HLA-DRB1, IL10
adaptive immune response (GO:0002250) 4.432CD244, HLA-DRB1
activation of immune response (GO:0002253) 3.672PTPN22, HLA-DRB1
phosphorus metabolic process (GO:0006793) 2.152CIITA, PTPN22
negative regulation of interferon-gamma production (GO:0032689) 6.262HLA-DRB1, IL10
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152IRF5, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of T cell proliferation (GO:0042130) -5.820.0CIITA, HLA-DRB1, IL10
detection of biotic stimulus (GO:0009595) NEW6.550.0HLA-DRB1, IL10
cytokine-mediated signaling pathway (GO:0019221) -3.60.0CIITA, IRF5, HLA-DRB1, IL10
regulation of secretion (GO:0051046) -3.20.011HLA-DRB1, IL10
positive regulation of secretion (GO:0051047) -3.850.0HLA-DRB1, IL10
positive regulation of response to stimulus (GO:0048584) -2.180.0PTPN22, HLA-DRB1
regulation of response to stimulus (GO:0048583) -1.540.0NFKBIL1, PTPN22, HLA-DRB1, IL10
signal transduction (GO:0007165) -1.280.0IRF5, HLA-DRB1, CD244, PTPN22, NFKBIL1, CIITA
cell surface receptor signaling pathway (GO:0007166) -2.090.0CIITA, PTPN22, IRF5, HLA-DRB1
cellular response to stimulus (GO:0051716) -1.970.0IRF5, NFKBIL1, CD244, IL10, PTPN22, HLA-DRB1, CIITA
response to external biotic stimulus (GO:0043207) -3.130.0NFKBIL1, IRF5, HLA-DRB1, IL10
response to bacterium (GO:0009617) -4.180.0IRF5, HLA-DRB1, IL10
regulation of leukocyte proliferation (GO:0070663) -4.40.0CIITA, PTPN22, HLA-DRB1, IL10
positive regulation of biological process (GO:0048518) -1.20.0CIITA, IRF5, PTPN22, HLA-DRB1, IL10
regulation of immune system process (GO:0002682) -2.50.0NFKBIL1, PTPN22, HLA-DRB1, IL10
detection of external biotic stimulus (GO:0098581) NEW6.680.0HLA-DRB1, IL10
regulation of interleukin-10 production (GO:0032653) NEW5.970.0CIITA, IRF5, HLA-DRB1
positive regulation of transport (GO:0051050) -2.90.025HLA-DRB1, IL10
regulation of T cell proliferation (GO:0042129) -4.740.0HLA-DRB1, IL10
response to other organism (GO:0051707) -3.480.0IRF5, HLA-DRB1, IL10
response to organic substance (GO:0010033) -2.20.0CIITA, NFKBIL1, HLA-DRB1, IL10, IRF5
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) NEW5.140.0CIITA, HLA-DRB1
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.0PTPN22, HLA-DRB1, IL10
T-helper 1 type immune response (GO:0042088) NEW7.330.0HLA-DRB1, IL10
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) NEW5.570.0HLA-DRB1, IL10
immune system process (GO:0002376) -2.290.0IRF5, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
regulation of interferon-gamma production (GO:0032649) -5.210.0IRF5, HLA-DRB1, IL10
antigen processing and presentation (GO:0019882) NEW4.360.0CIITA, HLA-DRB1, IL10
regulation of mononuclear cell proliferation (GO:0032944) -4.450.0CIITA, PTPN22, HLA-DRB1, IL10
negative regulation of mononuclear cell proliferation (GO:0032945) -5.590.0CIITA, HLA-DRB1, IL10
antigen processing and presentation of peptide antigen (GO:0048002) NEW4.560.0CIITA, HLA-DRB1, IL10
regulation of protein transport (GO:0051223) -3.120.0NFKBIL1, HLA-DRB1, IL10
regulation of protein secretion (GO:0050708) -3.770.003CIITA, HLA-DRB1, IL10
immune response-regulating signaling pathway (GO:0002764) -3.720.0PTPN22, HLA-DRB1, IL10
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.0PTPN22, HLA-DRB1, IL10
regulation of cytokine secretion (GO:0050707) -4.740.0CIITA, HLA-DRB1, IL10
macromolecular complex assembly (GO:0065003) -2.550.044PADI4, HLA-DRB1
positive regulation of immune system process (GO:0002684) -2.960.0CIITA, PTPN22, HLA-DRB1, IL10, IRF5
biological regulation (GO:0065007) -0.390.024IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
negative regulation of immune system process (GO:0002683) -3.850.0CIITA, NFKBIL1, PTPN22, HLA-DRB1, IL10
regulation of establishment of protein localization (GO:0070201) -3.020.0NFKBIL1, HLA-DRB1, IL10
antigen processing and presentation of exogenous antigen (GO:0019884) NEW4.590.0CIITA, HLA-DRB1, IL10
response to cytokine (GO:0034097) NEW3.840.0CIITA, IRF5, HLA-DRB1, IL10
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) NEW5.210.0CIITA, HLA-DRB1
defense response (GO:0006952) -2.780.002CIITA, IRF5, PADI4, HLA-DRB1, IL10
regulation of lymphocyte activation (GO:0051249) -3.730.0CIITA, PTPN22, HLA-DRB1, IL10
inflammatory response (GO:0006954) -3.640.0CIITA, HLA-DRB1, IL10
immune response (GO:0006955) -2.860.001CIITA, PADI4, HLA-DRB1, IL10
humoral immune response (GO:0006959) NEW4.590.0HLA-DRB1, IL10
immune response-activating signal transduction (GO:0002757) -3.80.0PTPN22, HLA-DRB1, IL10
lymphocyte mediated immunity (GO:0002449) NEW5.590.0HLA-DRB1, IL10
cellular response to cytokine stimulus (GO:0071345) NEW4.330.0CIITA, IRF5, HLA-DRB1, IL10
response to stimulus (GO:0050896) -1.220.0IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA
cellular response to interferon-gamma (GO:0071346) NEW5.780.0CIITA, IRF5, HLA-DRB1, IL10
negative regulation of leukocyte activation (GO:0002695) -4.790.0CIITA, PTPN22, HLA-DRB1, IL10
regulation of leukocyte activation (GO:0002694) -3.60.0CIITA, PTPN22, HLA-DRB1, IL10
positive regulation of leukocyte activation (GO:0002696) -4.00.0CIITA, HLA-DRB1, IL10
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) NEW5.190.0CIITA, HLA-DRB1
cellular response to chemical stimulus (GO:0070887) -2.570.0CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
regulation of protein localization (GO:0032880) -2.880.001NFKBIL1, HLA-DRB1, IL10
regulation of MHC class I biosynthetic process (GO:0045343) NEW7.780.02CIITA, IRF5, IL10
regulation of MHC class II biosynthetic process (GO:0045346) -7.160.036CIITA, IL10
positive regulation of MHC class II biosynthetic process (GO:0045348) -7.650.033CIITA, IL10
negative regulation of multicellular organismal process (GO:0051241) -2.840.0CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
negative regulation of cell proliferation (GO:0008285) -3.260.018HLA-DRB1, IL10
positive regulation of T cell activation (GO:0050870) -4.390.0HLA-DRB1, IL10
negative regulation of inflammatory response to antigenic stimulus (GO:0002862) -7.430.036HLA-DRB1, IL10
protein oligomerization (GO:0051259) NEW3.710.023CIITA, IRF5, HLA-DRB1, IL10
regulation of immune response (GO:0050776) -2.980.0IRF5, HLA-DRB1, IL10, PTPN22, NFKBIL1, CIITA
positive regulation of lymphocyte activation (GO:0051251) -4.070.0CIITA, HLA-DRB1, IL10
negative regulation of lymphocyte activation (GO:0051250) -4.950.0CIITA, PTPN22, HLA-DRB1, IL10
regulation of lymphocyte proliferation (GO:0050670) -4.460.0CIITA, PTPN22, HLA-DRB1, IL10
positive regulation of immune response (GO:0050778) -3.40.0CIITA, PTPN22, HLA-DRB1, IL10
negative regulation of lymphocyte proliferation (GO:0050672) -5.590.0CIITA, HLA-DRB1, IL10
regulation of cytokine production (GO:0001817) -3.40.023CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
negative regulation of cytokine production (GO:0001818) -4.40.0CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
response to biotic stimulus (GO:0009607) -3.090.0NFKBIL1, IRF5, HLA-DRB1, IL10
negative regulation of T cell activation (GO:0050868) -5.260.0CIITA, PTPN22, HLA-DRB1, IL10
regulation of cellular localization (GO:0060341) -3.030.019NFKBIL1, HLA-DRB1, IL10
regulation of cell activation (GO:0050865) -3.530.0CIITA, PTPN22, HLA-DRB1, IL10
positive regulation of cell activation (GO:0050867) -3.970.0CIITA, HLA-DRB1, IL10
negative regulation of cell activation (GO:0050866) -4.670.0CIITA, PTPN22, HLA-DRB1, IL10
regulation of T cell activation (GO:0050863) -4.050.0PTPN22, HLA-DRB1, IL10
antigen processing and presentation of exogenous peptide antigen (GO:0002478) NEW4.630.0CIITA, HLA-DRB1, IL10
cellular response to organic substance (GO:0071310) -2.780.0CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
negative regulation of leukocyte proliferation (GO:0070664) -5.520.0CIITA, HLA-DRB1, IL10
response to external stimulus (GO:0009605) -2.550.027NFKBIL1, HLA-DRB1, IL10, IRF5
antigen receptor-mediated signaling pathway (GO:0050851) -4.430.0PTPN22, HLA-DRB1, IL10
T cell receptor signaling pathway (GO:0050852) -4.710.0PTPN22, HLA-DRB1
protein complex assembly (GO:0006461) -2.780.014PADI4, HLA-DRB1
response to interferon-gamma (GO:0034341) NEW5.40.0CIITA, IRF5, HLA-DRB1, IL10
interferon-gamma-mediated signaling pathway (GO:0060333) -5.480.0CIITA, IRF5, HLA-DRB1
response to chemical (GO:0042221) -1.980.0CIITA, NFKBIL1, IRF5, HLA-DRB1, IL10
leukocyte mediated immunity (GO:0002443) NEW5.310.0HLA-DRB1, IL10
adaptive immune response (GO:0002250) -4.430.0HLA-DRB1, IL10
activation of immune response (GO:0002253) -3.670.0CIITA, PTPN22, HLA-DRB1, IL10
immune effector process (GO:0002252) -3.580.004CIITA, IRF5, HLA-DRB1, IL10
negative regulation of interferon-gamma production (GO:0032689) -6.260.0HLA-DRB1, IL10
positive regulation of cellular process (GO:0048522) -1.30.0CIITA, IRF5, HLA-DRB1, IL10
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.119IRF5, NFKBIL1, CD244, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
intracellular part (GO:0044424) 0.288IRF5, NFKBIL1, IL10, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
intracellular organelle (GO:0043229) 0.517IRF5, NFKBIL1, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
membrane-bounded organelle (GO:0043227) 0.477IRF5, NFKBIL1, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
intracellular membrane-bounded organelle (GO:0043231) 0.67IRF5, NFKBIL1, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
organelle (GO:0043226) 0.47IRF5, NFKBIL1, PTPN22, PADI4, HLA-DRB1, CIITA, SLC22A4
cytoplasmic part (GO:0044444) 0.826IRF5, HLA-DRB1, PTPN22, PADI4, NFKBIL1, SLC22A4
nucleus (GO:0005634) 1.075CIITA, PTPN22, PADI4, IRF5, NFKBIL1
cytoplasm (GO:0005737) 1.014PTPN22, PADI4, IRF5, IL10
membrane part (GO:0044425) 0.954HLA-DRB1, PTPN22, CD244, SLC22A4
plasma membrane part (GO:0044459) 1.954CD244, SLC22A4, PTPN22, HLA-DRB1
intracellular organelle part (GO:0044446) 0.814CIITA, PADI4, NFKBIL1, HLA-DRB1
organelle part (GO:0044422) 0.794CIITA, PADI4, NFKBIL1, HLA-DRB1
integral component of membrane (GO:0016021) 1.143CD244, HLA-DRB1, SLC22A4
membrane (GO:0016020) 0.683CD244, HLA-DRB1, SLC22A4
nucleoplasm (GO:0005654) 1.893CIITA, PADI4, NFKBIL1
nuclear part (GO:0044428) 1.553CIITA, PADI4, NFKBIL1
plasma membrane (GO:0005886) 1.393CD244, HLA-DRB1, SLC22A4
side of membrane (GO:0098552) 4.223PTPN22, CD244, HLA-DRB1
cytosol (GO:0005829) 1.683IRF5, PADI4, NFKBIL1
intrinsic component of membrane (GO:0031224) 1.133CD244, HLA-DRB1, SLC22A4
external side of plasma membrane (GO:0009897) 4.462CD244, HLA-DRB1
extracellular space (GO:0005615) 2.632HLA-DRB1, IL10
cell surface (GO:0009986) 3.442CIITA, HLA-DRB1
integral component of plasma membrane (GO:0005887) 2.572HLA-DRB1, SLC22A4
intrinsic component of plasma membrane (GO:0031226) 2.532HLA-DRB1, SLC22A4
extracellular region part (GO:0044421) 1.572HLA-DRB1, IL10

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.0CD244, HLA-DRB1, IL10
integral component of endoplasmic reticulum membrane (GO:0030176) NEW5.010.0HLA-DRB1, IL10
integral component of organelle membrane (GO:0031301) NEW4.850.0HLA-DRB1, IL10
side of membrane (GO:0098552) -4.220.0HLA-DRB1, PTPN22, CD244, IL10
endosome membrane (GO:0010008) NEW3.830.0CIITA, IRF5, HLA-DRB1, IL10
endocytic vesicle membrane (GO:0030666) NEW4.820.0HLA-DRB1, IL10
organelle membrane (GO:0031090) NEW1.970.0CIITA, IRF5, HLA-DRB1, IL10
coated vesicle membrane (GO:0030662) NEW5.00.0HLA-DRB1, IL10
integral component of membrane (GO:0016021) -1.140.01CD244, HLA-DRB1, SLC22A4
cytoplasmic vesicle part (GO:0044433) NEW3.410.0CIITA, IRF5, HLA-DRB1, IL10
endoplasmic reticulum part (GO:0044432) NEW2.730.0CIITA, HLA-DRB1, IL10
Golgi apparatus part (GO:0044431) NEW3.00.0CIITA, IRF5, HLA-DRB1, IL10
vacuolar part (GO:0044437) NEW3.260.0IRF5, HLA-DRB1
plasma membrane part (GO:0044459) -1.950.0IRF5, CD244, IL10, PTPN22, HLA-DRB1, CIITA, SLC22A4
late endosome membrane (GO:0031902) NEW5.160.0IRF5, HLA-DRB1
transport vesicle membrane (GO:0030658) NEW4.860.0HLA-DRB1, IL10
cytoplasmic vesicle membrane (GO:0030659) NEW3.670.0IRF5, HLA-DRB1, IL10
vesicle membrane (GO:0012506) NEW3.630.0IRF5, HLA-DRB1, IL10
plasma membrane (GO:0005886) -1.390.017IRF5, IL10, CD244, HLA-DRB1, CIITA, SLC22A4
MHC protein complex (GO:0042611) NEW6.430.0HLA-DRB1, IL10
macromolecular complex (GO:0032991) NEW1.350.014IRF5, NFKBIL1, IL10, CD244, PADI4, HLA-DRB1, CIITA
Golgi membrane (GO:0000139) NEW3.280.0CIITA, IRF5, HLA-DRB1, IL10
cytoplasmic part (GO:0044444) -0.820.019NFKBIL1, PTPN22, HLA-DRB1, SLC22A4, IRF5
endosomal part (GO:0044440) NEW3.730.0CIITA, IRF5, HLA-DRB1, IL10
membrane part (GO:0044425) -0.950.029HLA-DRB1, PTPN22, CD244, SLC22A4