Gene table of SOS1 : SOS Ras/Rac guanine nucleotide exchange factor 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with SOS1OMIM linkNumber of associated genesgenes
PS163950NOONAN SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 9LZTR1, BRAF, RIT1, NRAS, KRAS, SOS2, PTPN11, SOS1, RAF1
PS135300GINGIVAL FIBROMATOSISClinVar, OMIM link to OMIM 1SOS1

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Annotation of the gene SOS1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
FoxO signaling pathwayhsa040685.63
Natural killer cell mediated cytotoxicityhsa046505.53
Renal cell carcinomahsa052116.6
Gliomahsa052146.66
Jak-STAT signaling pathwayhsa046305.44
Neurotrophin signaling pathwayhsa047225.78
Choline metabolism in cancerhsa052316.09
Focal adhesionhsa045104.92
Chemokine signaling pathwayhsa040625.19
Endometrial cancerhsa052136.81
PI3K-Akt signaling pathwayhsa041514.21
Hepatitis Chsa051605.68
Gap junctionhsa045406.24
Proteoglycans in cancerhsa052055.02
Estrogen signaling pathwayhsa049156.11
MicroRNAs in cancerhsa052065.38
Pathways in cancerhsa052003.98
GnRH signaling pathwayhsa049126.18
Insulin signaling pathwayhsa049105.55
Ras signaling pathwayhsa040144.9
Fc epsilon RI signaling pathwayhsa046646.6
Prolactin signaling pathwayhsa049176.6
Acute myeloid leukemiahsa052216.74
Chronic myeloid leukemiahsa052206.48
Prostate cancerhsa052156.11
Regulation of actin cytoskeletonhsa048104.9
T cell receptor signaling pathwayhsa046606.01
MAPK signaling pathwayhsa040104.63
B cell receptor signaling pathwayhsa046626.52
Dorso-ventral axis formationhsa043208.01
Alcoholismhsa050345.59
Non-small cell lung cancerhsa052236.88
ErbB signaling pathwayhsa040126.15
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Robo receptorR-HSA-3761767.98
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.73
Constitutive Signaling by EGFRvIIIR-HSA-56378109.08
Signaling by EGFRvIII in CancerR-HSA-56378129.08
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by FGFR1 in diseaseR-HSA-56553027.81
Signaling by EGFRR-HSA-1779294.59
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-3541949.08
Integrin alphaIIb beta3 signalingR-HSA-3541928.23
DAP12 interactionsR-HSA-21721274.56
Tie2 SignalingR-HSA-2109938.81
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Frs2-mediated activationR-HSA-1709685.12
Downstream signal transductionR-HSA-1867634.65
RAF/MAP kinase cascadeR-HSA-56730015.15
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
SHC-mediated cascade:FGFR3R-HSA-56547048.81
Signaling by EGFR in CancerR-HSA-16437138.73
Signaling by FGFR in diseaseR-HSA-12260997.49
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
Signal attenuationR-HSA-747499.66
SHC-mediated cascade:FGFR4R-HSA-56547198.46
SHC-related events triggered by IGF1RR-HSA-24289339.81
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
Cell death signalling via NRAGE, NRIF and NADER-HSA-2049987.05
EGFR Transactivation by GastrinR-HSA-21793929.81
Axon guidanceR-HSA-4224753.93
Signaling by FGFR2 in diseaseR-HSA-56552538.23
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Activation of RacR-HSA-4285409.18
Signaling by FGFR3 in diseaseR-HSA-56553328.52
Signaling by LeptinR-HSA-25865525.1
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
SHC-mediated cascade:FGFR1R-HSA-56546888.59
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-9836955.6
Diseases of signal transductionR-HSA-56632024.89
FCERI mediated Ca+2 mobilizationR-HSA-28718095.45
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
SHC-mediated cascade:FGFR2R-HSA-56546998.28
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
Rho GTPase cycleR-HSA-1948406.04
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Signaling by Rho GTPasesR-HSA-1943154.43
Cell surface interactions at the vascular wallR-HSA-2027336.32
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
Platelet Aggregation (Plug Formation)R-HSA-760097.77
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Platelet activation, signaling and aggregationR-HSA-760025.15
NRAGE signals death through JNKR-HSA-1936487.49
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Regulation of KIT signalingR-HSA-14335598.98
Signaling by FGFRR-HSA-1902364.67
G alpha (12/13) signalling eventsR-HSA-4164826.75
GPCR downstream signalingR-HSA-3883963.07
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.73
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signaling by FGFR4 in diseaseR-HSA-56552919.52
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Rho guanyl-nucleotide exchange factor activityGO:00050895.37
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
protein heterodimerization activityGO:00469823.64
protein bindingGO:00055150.46
organic cyclic compound bindingGO:00971591.05
enzyme regulator activityGO:00302342.85
guanyl-nucleotide exchange factor activityGO:00050854.02
SH3 domain bindingGO:00171244.98
GTPase activator activityGO:00050964.11
GTPase regulator activityGO:00306954.01
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
enzyme activator activityGO:00080473.56
protein dimerization activityGO:00469832.72
molecular function regulatorGO:00987722.51
nucleoside-triphosphatase regulator activityGO:00605893.92
heterocyclic compound bindingGO:19013631.06
protein domain specific bindingGO:00199043.32