Disease table of NOONAN SYNDROME OMIM ID: PS163950

Gene-disease associations table

Gene	Associated with NOONAN SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
SOS2	ClinVar, OMIM, HUMSAVAR	HGNC link	14q21.3	1	PS163950
SOS1	ClinVar, OMIM, HUMSAVAR	HGNC link	2p22.1	2	PS163950, PS135300
RAF1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.2	3	PS163950, PS115200, PS151100
PTPN11	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.13	4	PS163950, 607785, 156250, PS151100
NRAS	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.2	8	137550, PS163950, 249400, 163200, 607785, 114500, 614470, 162900
RIT1	ClinVar, OMIM, HUMSAVAR	HGNC link	1q22	1	PS163950
BRAF	ClinVar, OMIM, HUMSAVAR	HGNC link	7q34	8	605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
LZTR1	ClinVar, OMIM, HUMSAVAR	HGNC link	22q11.21	2	PS163950, PS162091
KRAS	ClinVar, OMIM, HUMSAVAR	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	KRAS, PTPN11
1	2	NRAS, RIT1

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
NRAS	YES	1	AR	0
KRAS	YES	1	MYC	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SOS2	SOS1	No	10	PLCG1, BIN1, LRRK1, SHC1, CRK, ITSN2, EGFR, NTRK1, GRB2, DLG4
SOS2	RAF1	No	1	EGFR
SOS2	PTPN11	No	5	CRK, LRRK1, GRB2, NTRK1, EGFR
SOS1	RAF1	No	5	SH3KBP1, LCK, HRAS, FYN, EGFR
SOS1	PTPN11	Yes	11	PTPN11, LRRK1, CBL, CRK, PIK3R1, GRB2, EGFR, NTRK1, FYN, FRS2, CRKL
SOS1	RIT1	No	1	NF2
SOS1	BRAF	No	1	HRAS
SOS1	LZTR1	No	2	NCK2, RIT2
RAF1	PTPN11	No	7	PDGFRB, MAP2K1, JAK1, JAK2, MAP3K5, EGFR, FYN
RAF1	NRAS	Yes	2	EEF1A1, RAF1
RAF1	BRAF	Yes	26	MAP2K2, CDC37, YWHAE, MAPK1, BRAF, NEDD4L, KSR1, RAP1A, HSPA5, YWHAB, YWHAH, PRKCE, BRAP, RAF1, YWHAZ, HRAS, HSP90AA1, AKT1, BAD, HSPA8, MRAS, MAPK3, YWHAG, SFN, YWHAQ, MAP2K1
RAF1	KRAS	Yes	7	PHB, CALM1, BCL2, MAPK1, RAF1, EEF1A1, SHOC2
PTPN11	NRAS	No	1	ELAVL1
PTPN11	BRAF	No	1	MAP2K1
PTPN11	KRAS	No	2	PIK3R2, ELAVL1
NRAS	RIT1	No	1	MLLT4
NRAS	BRAF	No	1	RAF1
NRAS	KRAS	No	6	RGL2, RAP1GDS1, ELAVL1, PIK3CG, RAF1, EEF1A1
RIT1	KRAS	No	1	RALGDS
BRAF	KRAS	No	3	MAPK1, ARAF, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SOS2	SOS1	Yes	binding	59	PLCG1, RHOV, RRAS2, RHOU, GRAPL, RAC1, PRKX, CDC42, RRAS, EGFR, VAV2, PRKACA, RHOJ, RASGRP1, ROBO1, FGFR2, MAPK11, FGFR3, RHOA, RHOT2, RHOH, RHOC, NCK1, MAPK14, FGFR4, CD2AP, GPC1, PRKG1, GRAP, MAPK1, HRAS, NCK2, MAPK13, SHC1, PRKACG, RHOG, ABL1, RHOBTB1, PDGFRA, GRB2, GRAP2, MAPK12, RHOB, SLIT2, PDGFRB, RHOT1, PTPN11, FGFR1, MRAS, MAPK3, RASGRP3, RHOD, PRKACB, RHOF, INSRR, RHOBTB2, PRKG2, RHOQ, RAC3
SOS2	RAF1	No	-	17	RAC1, PRKX, PDGFRB, MAPK3, HRAS, RRAS2, MAPK1, RRAS, PRKACG, CDC42, PRKACB, PRKG1, RHOA, PRKACA, PRKG2, MRAS, RAC3
SOS2	PTPN11	Yes	activation, binding	16	PLCG1, PRKACA, PDGFRB, MAPK11, MAPK1, HRAS, MAPK3, SOS1, MAPK14, GRB2, EGFR, RHOA, MAPK12, SHC1, MAPK13, VAV2
SOS2	BRAF	No	-	6	MAPK3, HRAS, MAPK1, RRAS, PRKACA, MRAS
SOS2	KRAS	No	-	15	RASGRP1, PTPN11, MAPK13, MAPK11, MAPK1, HRAS, MAPK3, SOS1, RASGRP3, ABL1, MAPK12, GRB2, EGFR, SHC1, MAPK14
SOS1	RAF1	No	-	51	FCER1A, DOK1, MS4A2, PRKCZ, RRAS2, MAPK1, JAK2, PAK2, AGT, PIK3CA, RAP1A, PRKACA, RAP1B, FCER1G, PDGFRB, PRKCD, YWHAH, MAP2K2, RRAS, PRKACB, PAK1, IGF1, LCK, HRAS, VAV1, RANBP9, PIK3CB, HSP90AA1, AKT1, RHOA, SRC, FYN, IL2, KRAS, PRKX, RAC1, IL3, IGF1R, MAPK3, PRKACG, GNB2L1, SPRY2, MRAS, JAK1, PRKG1, UBC, CDC42, PIK3CD, PRKG2, MAP2K1, RAC3
SOS1	PTPN11	Yes	activation, binding	101	MS4A2, RET, PLCG1, CAV1, RAP1A, PDGFB, TEK, VEGFA, KITLG, PDGFRB, PTK2, SOS2, CSF2RA, MAPK14, SGMS1, MAPK13, PIK3CB, AKT1, IL2, CBL, MAPK3, CCND3, MTOR, INS, PIK3R1, IGF1, FRS2, EGFR, FLT1, JAK2, PRKACA, RHOA, JAK1, UGCG, HGF, GRB2, VAV2, INSR, IGF1R, SPRY2, CSF2RB, UBC, GAB1, MAP2K2, SMPD1, A2M, SYK, RAP1B, MAPK11, KRAS, MET, ERBB3, LCP2, GDNF, LRPPRC, KIT, LCK, HRAS, IL3RA, GAB2, DOK1, FCER1G, MAPK12, YES1, PRKCZ, IL2RB, PIK3CD, EPOR, FCER1A, HCK, LYN, IRS1, GNAI1, ANGPT1, ITSN1, CRK, MAP2K1, PIK3CA, ERBB2, SHC1, GNB1, CSF2, SDC2, FRS3, LMO4, EGF, VAV1, SRC, FYN, IL6ST, GFRA1, IL6R, KDR, IL3, PTK2B, MAPK1, GNB2L1, IL6, IRS2, LAT, ERBB4
SOS1	RIT1	No	-	1	RIT2
SOS1	BRAF	No	-	21	HSP90AA1, MAP2K2, YWHAH, RAP1A, RPS6KA2, CRK, MAPK1, MRAS, MAPK3, RRAS, SPRY2, PRKCD, PAK2, KRAS, AKT1, UBC, PRKACA, RAP1B, HRAS, RIT2, MAP2K1
SOS1	KRAS	Yes	activation, binding	55	PTPN11, AKT1, SPTAN1, MAPK1, RET, MAP2K2, SHC1, SPTBN4, MAPK14, SHC2, EGFR, HBEGF, TEK, VEGFA, HSP90AA1, RASGRP3, SPTBN1, MAPK11, NCAM1, MAP2K1, PTK2, ERBB2, ERBB3, MAPK12, KIT, SPRY2, HRAS, ANGPT1, MAPK13, UBC, PIK3CB, SPTBN2, ABL1, SRC, FYN, GRB2, SPTBN5, YES1, SPTA1, ITSN1, SPTB, MEN1, MAPK3, SHC3, MTOR, RASGRP1, ERBB4, IRS2, PIK3CA, EGF, IRS1, FRS2, PTPRA, PIK3CD, TSG101
RAF1	PTPN11	No	-	50	PIK3R3, FCER1A, RAP1A, MS4A2, PRKCZ, MAPK3, TP53, MAPK1, JAK2, SRC, KRAS, PIK3CG, PRKACA, RAP1B, FCER1G, RPS27A, STAT2, PDGFRB, CXCL12, MAP2K2, PIK3CA, UBA52, MAPK7, INPP5D, LCK, HRAS, NOS3, VAV1, PIK3CB, DOK1, PPP2CA, AKT1, RHOA, PPP2R1A, FYN, MYC, STAT3, IL2, UBB, IL3, IGF1R, HSPA4, GNB2L1, SPRY2, JAK1, IGF1, UBC, PIK3CD, PIK3R5, MAP2K1
RAF1	RIT1	No	-	1	BRAF
RAF1	BRAF	Yes	binding	40	MAP2K2, HSP90AB1, CDC37, KSR2, YWHAE, MAPK1, PPP2CA, PAK2, KSR1, RAP1A, PRKACA, RAP1B, YWHAB, PRKCE, PRKCD, YWHAH, RRAS, CNKSR3, PRKCG, RHEB, YWHAZ, PRKCA, HRAS, HSP90AA1, PPP2R2B, AKT1, PAK4, PPP2R1A, KRAS, PRKCB, MRAS, MAPK3, SPRY2, YWHAG, SFN, UBC, PRKCQ, PIN1, YWHAQ, MAP2K1
RAF1	KRAS	Yes	activation, binding	32	MAP2K2, RASA1, MAPK3, KSR2, BCL2L1, TP53, BRAF, KSR1, PIK3CG, YWHAB, BCL2, MAP2K1, PPP2CA, PIK3CA, CNKSR3, IL8, SHOC2, MAPK7, AKT2, HRAS, HSP90AA1, PIK3CB, ETS2, AKT1, SRC, FYN, RALGDS, MAPK1, SPRY2, UBC, PIK3CD, CCND1
PTPN11	BRAF	No	-	15	MAP2K2, AKT1, CRK, MAPK1, HRAS, MAPK3, PPP2CA, SPRY2, UBC, KRAS, RAP1A, PPP2R1A, PRKACA, RAP1B, MAP2K1
PTPN11	KRAS	Yes	activation, binding	44	MAP2K2, EGFR, MAPK1, RET, TP53, SHC1, PIK3CA, PIK3CG, TEK, VEGFA, GRB2, ANGPT1, MAPK11, MAP2K1, PTK2, EPHA2, ERBB2, ERBB3, SOS1, MAPK12, MAPK7, KIT, HRAS, MAPK13, FRS2, UBC, PIK3CB, PPP2CA, AKT1, SRC, FYN, MAPK14, YES1, ITSN1, MAPK3, JUN, MTOR, SPRY2, IRS2, EGF, IRS1, PIK3CD, MLLT4, ERBB4
RIT1	BRAF	Yes	activation, binding	1	RIT2
RIT1	KRAS	No	-	4	MAP3K19, MAP3K2, MAP3K3, BRAF
BRAF	KRAS	Yes	activation, binding	16	MAP2K2, RAF1, ARAF, MAPK1, HRAS, MAPK3, PPP2CA, SPRY2, CNKSR3, KSR2, HSP90AA1, AKT1, UBC, MAP2K1, YWHAB, KSR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
SOS1	PTPN11	No	-	3	PLCG1, GRB2, PIK3R1
RAF1	NRAS	Yes	RAF1-RAS complex, EGF induced	2	HRAS, KRAS
RAF1	BRAF	Yes	RAF1-BRAF complex, RAS stimulated;BRAF-RAF1-14-3-3 complex;MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex	11	MAP2K2, YWHAH, YWHAE, KSR1, YWHAG, YWHAB, SFN, CNKSR1, YWHAQ, MAP2K1, YWHAZ
RAF1	KRAS	Yes	RAF1-RAS complex, EGF induced	2	HRAS, NRAS
NRAS	BRAF	No	-	1	RAF1
NRAS	KRAS	Yes	RAF1-RAS complex, EGF induced	2	HRAS, RAF1
BRAF	KRAS	No	-	1	RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
SOS1	RAF1	No	1	HRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
KRAS	NRAS	maybe, indirect	They are members of the same protein family.

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Neurotrophin signaling pathway	hsa04722	5.78	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Natural killer cell mediated cytotoxicity	hsa04650	5.53	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Renal cell carcinoma	hsa05211	6.6	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Proteoglycans in cancer	hsa05205	5.02	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Chronic myeloid leukemia	hsa05220	6.48	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Acute myeloid leukemia	hsa05221	6.74	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Endometrial cancer	hsa05213	6.81	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Alcoholism	hsa05034	5.59	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Pathways in cancer	hsa05200	3.98	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Glioma	hsa05214	6.66	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Hepatitis C	hsa05160	5.68	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Insulin signaling pathway	hsa04910	5.55	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Ras signaling pathway	hsa04014	4.9	6	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Non-small cell lung cancer	hsa05223	6.88	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
ErbB signaling pathway	hsa04012	6.15	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
FoxO signaling pathway	hsa04068	5.63	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
MAPK signaling pathway	hsa04010	4.63	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Prostate cancer	hsa05215	6.11	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Chemokine signaling pathway	hsa04062	5.19	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Regulation of actin cytoskeleton	hsa04810	4.9	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
T cell receptor signaling pathway	hsa04660	6.01	5	SOS2, KRAS, RAF1, NRAS, SOS1
Gap junction	hsa04540	6.24	5	SOS2, KRAS, RAF1, NRAS, SOS1
MicroRNAs in cancer	hsa05206	5.38	5	SOS2, KRAS, NRAS, RAF1, SOS1
Prolactin signaling pathway	hsa04917	6.6	5	SOS2, KRAS, RAF1, NRAS, SOS1
GnRH signaling pathway	hsa04912	6.18	5	SOS2, KRAS, NRAS, RAF1, SOS1
B cell receptor signaling pathway	hsa04662	6.52	5	SOS2, KRAS, NRAS, RAF1, SOS1
Fc epsilon RI signaling pathway	hsa04664	6.6	5	SOS2, KRAS, NRAS, RAF1, SOS1
Choline metabolism in cancer	hsa05231	6.09	5	SOS2, KRAS, NRAS, RAF1, SOS1
Estrogen signaling pathway	hsa04915	6.11	5	SOS2, KRAS, NRAS, RAF1, SOS1
PI3K-Akt signaling pathway	hsa04151	4.21	5	SOS2, KRAS, NRAS, RAF1, SOS1
Melanoma	hsa05218	6.56	4	BRAF, KRAS, RAF1, NRAS
Bladder cancer	hsa05219	7.38	4	BRAF, KRAS, NRAS, RAF1
Long-term potentiation	hsa04720	6.64	4	BRAF, KRAS, NRAS, RAF1
Rap1 signaling pathway	hsa04015	4.97	4	BRAF, KRAS, RAF1, NRAS
Focal adhesion	hsa04510	4.92	4	BRAF, SOS2, SOS1, RAF1
Serotonergic synapse	hsa04726	5.84	4	BRAF, KRAS, NRAS, RAF1
Long-term depression	hsa04730	6.74	4	BRAF, KRAS, NRAS, RAF1
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	3	KRAS, RAF1, NRAS
VEGF signaling pathway	hsa04370	6.77	3	KRAS, RAF1, NRAS
Pancreatic cancer	hsa05212	6.56	3	BRAF, KRAS, RAF1
Colorectal cancer	hsa05210	6.52	3	BRAF, KRAS, RAF1
Thyroid cancer	hsa05216	7.48	3	BRAF, KRAS, NRAS
Jak-STAT signaling pathway	hsa04630	5.44	3	PTPN11, SOS2, SOS1
Central carbon metabolism in cancer	hsa05230	6.7	3	KRAS, RAF1, NRAS
Dorso-ventral axis formation	hsa04320	8.01	3	SOS2, KRAS, SOS1
Progesterone-mediated oocyte maturation	hsa04914	6.18	3	BRAF, KRAS, RAF1
Melanogenesis	hsa04916	5.97	3	KRAS, NRAS, RAF1
Thyroid hormone signaling pathway	hsa04919	5.82	3	KRAS, NRAS, RAF1
Hepatitis B	hsa05161	5.52	3	KRAS, RAF1, NRAS
Oxytocin signaling pathway	hsa04921	5.4	3	KRAS, NRAS, RAF1
cAMP signaling pathway	hsa04024	5.05	2	BRAF, RAF1
Tight junction	hsa04530	5.53	2	KRAS, NRAS
Cholinergic synapse	hsa04725	5.88	2	KRAS, NRAS
Viral carcinogenesis	hsa05203	5.08	2	KRAS, NRAS
Axon guidance	hsa04360	5.63	2	KRAS, NRAS
HTLV-I infection	hsa05166	4.59	2	KRAS, NRAS
Vascular smooth muscle contraction	hsa04270	5.74	2	BRAF, RAF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Melanoma (hsa05218)	-	6.56	0.0	BRAF, KRAS, RAF1, NRAS
Bladder cancer (hsa05219)	-	7.38	0.0	BRAF, KRAS, RAF1, NRAS
Progesterone-mediated oocyte maturation (hsa04914)	-	6.18	0.007	SOS2, BRAF, RAF1, KRAS, SOS1
Pancreatic cancer (hsa05212)	-	6.56	0.02	BRAF, KRAS, RAF1
Natural killer cell mediated cytotoxicity (hsa04650)	-	5.53	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Colorectal cancer (hsa05210)	-	6.52	0.02	BRAF, KRAS, RAF1
Renal cell carcinoma (hsa05211)	-	6.6	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Osteoclast differentiation (hsa04380)	NEW	5.64	0.012	PTPN11, SOS2, RAF1, SOS1
Signaling pathways regulating pluripotency of stem cells (hsa04550)	-	5.6	0.024	KRAS, RAF1, NRAS
cAMP signaling pathway (hsa04024)	-	5.05	0.003	PTPN11, SOS2, BRAF, RAF1, SOS1
Jak-STAT signaling pathway (hsa04630)	-	5.44	0.008	PTPN11, SOS2, RAF1, SOS1
Tight junction (hsa04530)	-	5.53	0.0	LZTR1, KRAS, RAF1, NRAS, BRAF
Nervous system	NEW	3.77	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.013	KRAS, NRAS, RAF1
Choline metabolism in cancer (hsa05231)	-	6.09	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Immune system	NEW	2.92	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Serotonergic synapse (hsa04726)	-	5.84	0.0	BRAF, KRAS, NRAS, RAF1, SOS1
Chemokine signaling pathway (hsa04062)	-	5.19	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Oxytocin signaling pathway (hsa04921)	-	5.4	0.001	SOS2, KRAS, NRAS, RAF1, SOS1
Development	NEW	4.58	0.001	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Cellular community	NEW	3.57	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
Thyroid hormone signaling pathway (hsa04919)	-	5.82	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Substance dependence	NEW	4.77	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
FoxO signaling pathway (hsa04068)	-	5.63	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Cancers: Overview	NEW	2.72	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ErbB signaling pathway (hsa04012)	-	6.15	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Insulin signaling pathway (hsa04910)	-	5.55	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Cholinergic synapse (hsa04725)	-	5.88	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Endometrial cancer (hsa05213)	-	6.81	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Apoptosis (hsa04210)	NEW	6.23	0.045	PTPN11, SOS2, SOS1
HTLV-I infection (hsa05166)	-	4.59	0.001	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Regulation of actin cytoskeleton (hsa04810)	-	4.9	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Hepatitis C (hsa05160)	-	5.68	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Hepatitis B (hsa05161)	-	5.52	0.029	KRAS, RAF1, NRAS
Chronic myeloid leukemia (hsa05220)	-	6.48	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Cancers: Specific types	NEW	4.1	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Gap junction (hsa04540)	-	6.24	0.0	SOS2, KRAS, RAF1, NRAS, SOS1
Circulatory system	NEW	4.63	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Proteoglycans in cancer (hsa05205)	-	5.02	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Thyroid cancer (hsa05216)	-	7.48	0.0	BRAF, KRAS, NRAS
Infectious diseases: Viral	NEW	3.29	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
MicroRNAs in cancer (hsa05206)	-	5.38	0.001	SOS2, KRAS, NRAS, RAF1, SOS1
Pathways in cancer (hsa05200)	-	3.98	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
GnRH signaling pathway (hsa04912)	-	6.18	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Signal transduction	NEW	2.06	0.004	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Rap1 signaling pathway (hsa04015)	-	4.97	0.003	PTPN11, KRAS, NRAS, RAF1, BRAF
Ras signaling pathway (hsa04014)	-	4.9	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Melanogenesis (hsa04916)	-	5.97	0.011	KRAS, NRAS, RAF1
Prolactin signaling pathway (hsa04917)	-	6.6	0.0	SOS2, KRAS, RAF1, NRAS, SOS1
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Estrogen signaling pathway (hsa04915)	-	6.11	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Prostate cancer (hsa05215)	-	6.11	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Cell motility	NEW	4.9	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Long-term depression (hsa04730)	-	6.74	0.0	BRAF, KRAS, RAF1, NRAS
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.003	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Human Diseases	NEW	1.54	0.049	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
T cell receptor signaling pathway (hsa04660)	-	6.01	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Focal adhesion (hsa04510)	-	4.92	0.003	SOS2, SOS1, RAF1, BRAF
Cellular Processes	NEW	2.22	0.047	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Long-term potentiation (hsa04720)	-	6.64	0.0	BRAF, KRAS, RAF1, NRAS, SOS1
VEGF signaling pathway (hsa04370)	-	6.77	0.002	SOS2, KRAS, NRAS, RAF1, SOS1
MAPK signaling pathway (hsa04010)	-	4.63	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Environmental Information Processing	NEW	1.71	0.022	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
B cell receptor signaling pathway (hsa04662)	-	6.52	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Dorso-ventral axis formation (hsa04320)	-	8.01	0.001	SOS2, KRAS, SOS1
Alcoholism (hsa05034)	-	5.59	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Non-small cell lung cancer (hsa05223)	-	6.88	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Glioma (hsa05214)	-	6.66	0.0	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Fc epsilon RI signaling pathway (hsa04664)	-	6.6	0.0	SOS2, KRAS, NRAS, RAF1, SOS1
Adrenergic signaling in cardiomyocytes (hsa04261)	NEW	5.44	0.017	PTPN11, KRAS, SOS2, SOS1
Endocrine system	NEW	3.26	0.014	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signalling by NGF	R-HSA-166520	4.23	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Axon guidance	R-HSA-422475	3.93	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	7	PTPN11, RIT1, NRAS, BRAF, SOS1, KRAS, RAF1
Developmental Biology	R-HSA-1266738	3.48	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by Interleukins	R-HSA-449147	4.71	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by Leptin	R-HSA-2586552	5.1	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
IGF1R signaling cascade	R-HSA-2428924	4.85	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Downstream signal transduction	R-HSA-186763	4.65	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by ERBB4	R-HSA-1236394	4.7	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by Insulin receptor	R-HSA-74752	4.73	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Insulin receptor signalling cascade	R-HSA-74751	4.85	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
MAPK family signaling cascades	R-HSA-5683057	4.89	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	6	RIT1, NRAS, BRAF, KRAS, SOS1, RAF1
IRS-mediated signalling	R-HSA-112399	4.87	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
DAP12 interactions	R-HSA-2172127	4.56	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by FGFR4	R-HSA-5654743	4.69	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by FGFR3	R-HSA-5654741	4.69	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by FGFR	R-HSA-190236	4.67	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Immune System	R-HSA-168256	2.37	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Innate Immune System	R-HSA-168249	3.17	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by SCF-KIT	R-HSA-1433557	4.73	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by PDGF	R-HSA-186797	4.53	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
DAP12 signaling	R-HSA-2424491	4.64	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by EGFR	R-HSA-177929	4.59	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signalling to ERKs	R-HSA-187687	5.04	6	RIT1, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by GPCR	R-HSA-372790	2.68	6	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
Signaling by FGFR2	R-HSA-5654738	4.68	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by FGFR1	R-HSA-5654736	4.69	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Signaling by ERBB2	R-HSA-1227986	4.66	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
Prolonged ERK activation events	R-HSA-169893	5.11	5	BRAF, KRAS, NRAS, RAF1, SOS1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	5	BRAF, KRAS, NRAS, RAF1, SOS1
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	5	BRAF, KRAS, RAF1, NRAS, SOS1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	5	BRAF, KRAS, NRAS, RAF1, SOS1
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	5	BRAF, KRAS, NRAS, RAF1, SOS1
Signaling by VEGF	R-HSA-194138	4.66	5	BRAF, KRAS, RAF1, NRAS, SOS1
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	5	BRAF, KRAS, RAF1, NRAS, SOS1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	5	BRAF, KRAS, RAF1, NRAS, SOS1
Interleukin-2 signaling	R-HSA-451927	5.05	5	BRAF, KRAS, NRAS, RAF1, SOS1
Frs2-mediated activation	R-HSA-170968	5.12	5	BRAF, KRAS, RAF1, NRAS, SOS1
ARMS-mediated activation	R-HSA-170984	5.12	5	BRAF, KRAS, NRAS, RAF1, SOS1
GRB2 events in EGFR signaling	R-HSA-179812	5.15	5	BRAF, KRAS, NRAS, RAF1, SOS1
Signalling to RAS	R-HSA-167044	5.08	5	BRAF, KRAS, NRAS, RAF1, SOS1
SOS-mediated signalling	R-HSA-112412	5.15	5	BRAF, KRAS, RAF1, NRAS, SOS1
Hemostasis	R-HSA-109582	3.98	5	PTPN11, KRAS, RAF1, NRAS, SOS1
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	5	BRAF, KRAS, RAF1, NRAS, SOS1
Adaptive Immune System	R-HSA-1280218	3.19	5	PTPN11, KRAS, RAF1, NRAS, SOS1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	5	BRAF, KRAS, NRAS, RAF1, SOS1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	5	BRAF, KRAS, RAF1, NRAS, SOS1
SHC1 events in EGFR signaling	R-HSA-180336	5.15	5	BRAF, KRAS, RAF1, NRAS, SOS1
RAF/MAP kinase cascade	R-HSA-5673001	5.15	5	BRAF, KRAS, NRAS, RAF1, SOS1
Negative regulation of MAPK pathway	R-HSA-5675221	7.66	4	BRAF, KRAS, NRAS, RAF1
Diseases of signal transduction	R-HSA-5663202	4.89	4	PTPN11, KRAS, SOS1, NRAS
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	4	PTPN11, KRAS, SOS1, NRAS
MAP2K and MAPK activation	R-HSA-5674135	7.66	4	BRAF, KRAS, NRAS, RAF1
Cell surface interactions at the vascular wall	R-HSA-202733	6.32	4	PTPN11, KRAS, SOS1, NRAS
Tie2 Signaling	R-HSA-210993	8.81	4	PTPN11, KRAS, SOS1, NRAS
RAF activation	R-HSA-5673000	8.34	4	BRAF, KRAS, RAF1, NRAS
SHC-mediated cascade:FGFR4	R-HSA-5654719	8.46	4	PTPN11, KRAS, SOS1, NRAS
Disease	R-HSA-1643685	3.33	4	PTPN11, KRAS, SOS1, NRAS
SHC-mediated cascade:FGFR2	R-HSA-5654699	8.28	4	PTPN11, KRAS, SOS1, NRAS
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	3	KRAS, NRAS, RAF1
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	PTPN11, KRAS, NRAS
Signaling by FGFR3 in disease	R-HSA-5655332	8.52	3	KRAS, SOS1, NRAS
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	R-HSA-1236382	8.73	3	KRAS, SOS1, NRAS
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	PTPN11, SOS1, RAF1
SHC-mediated cascade:FGFR1	R-HSA-5654688	8.59	3	KRAS, SOS1, NRAS
Signaling by FGFR1 in disease	R-HSA-5655302	7.81	3	KRAS, SOS1, NRAS
Signaling by Ligand-Responsive EGFR Variants in Cancer	R-HSA-5637815	8.73	3	KRAS, SOS1, NRAS
Signaling by FGFR4 in disease	R-HSA-5655291	9.52	3	KRAS, SOS1, NRAS
SHC-related events triggered by IGF1R	R-HSA-2428933	9.81	3	KRAS, SOS1, NRAS
Constitutive Signaling by EGFRvIII	R-HSA-5637810	9.08	3	KRAS, SOS1, NRAS
SHC-mediated cascade:FGFR3	R-HSA-5654704	8.81	3	KRAS, SOS1, NRAS
Signaling by EGFRvIII in Cancer	R-HSA-5637812	9.08	3	KRAS, SOS1, NRAS
EGFR Transactivation by Gastrin	R-HSA-2179392	9.81	3	KRAS, SOS1, NRAS
Signaling by EGFR in Cancer	R-HSA-1643713	8.73	3	KRAS, SOS1, NRAS
Signaling by FGFR2 in disease	R-HSA-5655253	8.23	3	KRAS, SOS1, NRAS
CD209 (DC-SIGN) signaling	R-HSA-5621575	8.59	3	KRAS, RAF1, NRAS
Signaling by FGFR in disease	R-HSA-1226099	7.49	3	KRAS, SOS1, NRAS
p38MAPK events	R-HSA-171007	9.28	2	KRAS, NRAS
Signaling by Robo receptor	R-HSA-376176	7.98	2	SOS2, SOS1
Activation of Rac	R-HSA-428540	9.18	2	SOS2, SOS1
Negative feedback regulation of MAPK pathway	R-HSA-5674499	10.4	2	BRAF, RAF1
p75 NTR receptor-mediated signalling	R-HSA-193704	6.59	2	SOS2, SOS1
Post NMDA receptor activation events	R-HSA-438064	7.85	2	BRAF, RAF1
CREB phosphorylation through the activation of Ras	R-HSA-442742	8.23	2	BRAF, RAF1
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	2	PTPN11, SOS1
Negative regulation of FGFR1 signaling	R-HSA-5654726	7.98	2	PTPN11, BRAF
Negative regulation of FGFR2 signaling	R-HSA-5654727	7.89	2	PTPN11, BRAF
Neuronal System	R-HSA-112316	4.82	2	BRAF, RAF1
Activation of RAS in B cells	R-HSA-1169092	10.66	2	KRAS, NRAS
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	R-HSA-112314	5.85	2	BRAF, RAF1
Transmission across Chemical Synapses	R-HSA-112315	5.28	2	BRAF, RAF1
Spry regulation of FGF signaling	R-HSA-1295596	9.18	2	PTPN11, BRAF
G alpha (12/13) signalling events	R-HSA-416482	6.75	2	SOS2, SOS1
GPCR downstream signaling	R-HSA-388396	3.07	2	SOS2, SOS1
Signaling by Rho GTPases	R-HSA-194315	4.43	2	SOS2, SOS1
Activation of NMDA receptor upon glutamate binding and postsynaptic events	R-HSA-442755	7.7	2	BRAF, RAF1
NRAGE signals death through JNK	R-HSA-193648	7.49	2	SOS2, SOS1
Regulation of RAS by GAPs	R-HSA-5658442	6.92	2	KRAS, NRAS
Negative regulation of FGFR4 signaling	R-HSA-5654733	8.03	2	PTPN11, BRAF
Negative regulation of FGFR3 signaling	R-HSA-5654732	8.12	2	PTPN11, BRAF
Rho GTPase cycle	R-HSA-194840	6.04	2	SOS2, SOS1
Cell death signalling via NRAGE, NRIF and NADE	R-HSA-204998	7.05	2	SOS2, SOS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by the B Cell Receptor (BCR) (R-HSA-983705)	-	4.62	0.028	PTPN11, KRAS, SOS2, NRAS, SOS1
Developmental Biology (R-HSA-1266738)	-	3.48	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by VEGF (R-HSA-194138)	-	4.66	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
FCERI mediated MAPK activation (R-HSA-2871796)	-	4.32	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
IRS-mediated signalling (R-HSA-112399)	-	4.87	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by Ligand-Responsive EGFR Variants in Cancer (R-HSA-5637815)	-	8.73	0.0	KRAS, SOS1, NRAS
Constitutive Signaling by EGFRvIII (R-HSA-5637810)	-	9.08	0.0	KRAS, SOS1, NRAS
Signaling by EGFRvIII in Cancer (R-HSA-5637812)	-	9.08	0.0	KRAS, SOS1, NRAS
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Spry regulation of FGF signaling (R-HSA-1295596)	-	9.18	0.017	PTPN11, BRAF
Signaling by FGFR1 in disease (R-HSA-5655302)	-	7.81	0.007	KRAS, SOS1, NRAS
Signaling by EGFR in Cancer (R-HSA-1643713)	-	8.73	0.0	KRAS, SOS1, NRAS
DAP12 interactions (R-HSA-2172127)	-	4.56	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Tie2 Signaling (R-HSA-210993)	-	8.81	0.0	PTPN11, KRAS, SOS1, NRAS
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
VEGFR2 mediated cell proliferation (R-HSA-5218921)	-	5.07	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
GRB2 events in ERBB2 signaling (R-HSA-1963640)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Frs2-mediated activation (R-HSA-170968)	-	5.12	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Downstream signal transduction (R-HSA-186763)	-	4.65	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
RAF activation (R-HSA-5673000)	-	8.34	0.0	BRAF, KRAS, NRAS, RAF1
RAF/MAP kinase cascade (R-HSA-5673001)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signalling to p38 via RIT and RIN (R-HSA-187706)	-	5.12	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
FRS-mediated FGFR2 signaling (R-HSA-5654700)	-	5.14	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
FRS-mediated FGFR4 signaling (R-HSA-5654712)	-	5.14	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
FRS-mediated FGFR3 signaling (R-HSA-5654706)	-	5.14	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SHC-mediated cascade:FGFR3 (R-HSA-5654704)	-	8.81	0.0	KRAS, SOS1, NRAS
Activation of RAS in B cells (R-HSA-1169092)	-	10.66	0.002	KRAS, NRAS
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR in disease (R-HSA-1226099)	-	7.49	0.011	KRAS, SOS1, NRAS
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Interleukin receptor SHC signaling (R-HSA-912526)	-	5.09	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Innate Immune System (R-HSA-168249)	-	3.17	0.007	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
SHC-mediated cascade:FGFR4 (R-HSA-5654719)	-	8.46	0.0	PTPN11, KRAS, SOS1, NRAS
SHC-related events triggered by IGF1R (R-HSA-2428933)	-	9.81	0.0	KRAS, SOS1, NRAS
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
GRB2 events in EGFR signaling (R-HSA-179812)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
EGFR Transactivation by Gastrin (R-HSA-2179392)	-	9.81	0.0	KRAS, SOS1, NRAS
Axon guidance (R-HSA-422475)	-	3.93	0.004	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR2 in disease (R-HSA-5655253)	-	8.23	0.0	KRAS, SOS1, NRAS
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Activation of Rac (R-HSA-428540)	-	9.18	0.017	SOS2, SOS1
Signaling by FGFR3 in disease (R-HSA-5655332)	-	8.52	0.0	KRAS, SOS1, NRAS
Signaling by Leptin (R-HSA-2586552)	-	5.1	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
MAP2K and MAPK activation (R-HSA-5674135)	-	7.66	0.0	BRAF, KRAS, NRAS, RAF1, SOS1
IGF1R signaling cascade (R-HSA-2428924)	-	4.85	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
IRS-related events triggered by IGF1R (R-HSA-2428928)	-	4.85	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by Insulin receptor (R-HSA-74752)	-	4.73	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Insulin receptor signalling cascade (R-HSA-74751)	-	4.85	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SHC-mediated cascade:FGFR1 (R-HSA-5654688)	-	8.59	0.0	KRAS, SOS1, NRAS
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.002	PTPN11, KRAS, SOS2, NRAS, SOS1
C-type lectin receptors (CLRs) (R-HSA-5621481)	-	6.06	0.03	KRAS, RAF1, NRAS, SOS1
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.033	PTPN11, KRAS, SOS2, NRAS, SOS1
Immune System (R-HSA-168256)	-	2.37	0.013	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
Signalling to RAS (R-HSA-167044)	-	5.08	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SHC-mediated cascade:FGFR2 (R-HSA-5654699)	-	8.28	0.0	PTPN11, KRAS, SOS1, NRAS
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SHC1 events in EGFR signaling (R-HSA-180336)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
FRS-mediated FGFR1 signaling (R-HSA-5654693)	-	5.14	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SHC1 events in ERBB2 signaling (R-HSA-1250196)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by EGFR (R-HSA-177929)	-	4.59	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
CD209 (DC-SIGN) signaling (R-HSA-5621575)	-	8.59	0.0	KRAS, RAF1, NRAS, SOS1
SHC1 events in ERBB4 signaling (R-HSA-1250347)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by PDGF (R-HSA-186797)	-	4.53	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192)	-	4.85	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
p38MAPK events (R-HSA-171007)	-	9.28	0.011	KRAS, NRAS
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Negative feedback regulation of MAPK pathway (R-HSA-5674499)	-	10.4	0.002	BRAF, RAF1
Cell surface interactions at the vascular wall (R-HSA-202733)	-	6.32	0.005	PTPN11, KRAS, SOS1, NRAS
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SOS-mediated signalling (R-HSA-112412)	-	5.15	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
MAPK1/MAPK3 signaling (R-HSA-5684996)	-	5.11	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Adaptive Immune System (R-HSA-1280218)	-	3.19	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signalling by NGF (R-HSA-166520)	-	4.23	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.013	PTPN11, KRAS, BRAF, RAF1, SOS1
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR (R-HSA-190236)	-	4.67	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
G alpha (12/13) signalling events (R-HSA-416482)	-	6.75	0.039	SOS2, SOS1, RAF1
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
DAP12 signaling (R-HSA-2424491)	-	4.64	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (R-HSA-1236382)	-	8.73	0.0	KRAS, SOS1, NRAS
Negative regulation of MAPK pathway (R-HSA-5675221)	-	7.66	0.0	BRAF, KRAS, NRAS, RAF1
Signalling to ERKs (R-HSA-187687)	-	5.04	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Signaling by FGFR4 in disease (R-HSA-5655291)	-	9.52	0.0	KRAS, SOS1, NRAS
Hemostasis (R-HSA-109582)	-	3.98	0.008	PTPN11, KRAS, RAF1, NRAS, SOS1
Signal Transduction (R-HSA-162582)	-	1.78	0.009	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
protein binding (GO:0005515)	0.46	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
organic cyclic compound binding (GO:0097159)	1.05	7	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
heterocyclic compound binding (GO:1901363)	1.06	7	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
carbohydrate derivative binding (GO:0097367)	2.03	5	BRAF, KRAS, NRAS, RAF1, RIT1
nucleotide binding (GO:0000166)	1.96	5	BRAF, KRAS, RAF1, NRAS, RIT1
small molecule binding (GO:0036094)	1.89	5	BRAF, KRAS, RAF1, NRAS, RIT1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	5	BRAF, KRAS, NRAS, RAF1, RIT1
ribonucleotide binding (GO:0032553)	2.19	5	BRAF, KRAS, NRAS, RAF1, RIT1
purine nucleoside binding (GO:0001883)	2.22	5	BRAF, KRAS, NRAS, RAF1, RIT1
ribonucleoside binding (GO:0032549)	2.22	5	BRAF, KRAS, RAF1, NRAS, RIT1
purine ribonucleotide binding (GO:0032555)	2.2	5	BRAF, KRAS, NRAS, RAF1, RIT1
purine nucleotide binding (GO:0017076)	2.19	5	BRAF, KRAS, NRAS, RAF1, RIT1
purine ribonucleoside binding (GO:0032550)	2.22	5	BRAF, KRAS, NRAS, RAF1, RIT1
nucleoside phosphate binding (GO:1901265)	1.96	5	BRAF, KRAS, RAF1, NRAS, RIT1
nucleoside binding (GO:0001882)	2.21	5	BRAF, KRAS, RAF1, NRAS, RIT1
catalytic activity (GO:0003824)	1.05	4	PTPN11, KRAS, BRAF, RAF1
protein dimerization activity (GO:0046983)	2.72	4	SOS2, SOS1, RAF1, BRAF
protein heterodimerization activity (GO:0046982)	3.64	4	BRAF, SOS2, SOS1, RAF1
hydrolase activity (GO:0016787)	1.9	3	PTPN11, KRAS, RAF1
guanyl nucleotide binding (GO:0019001)	3.73	3	KRAS, RIT1, NRAS
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	PTPN11, BRAF, RAF1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	PTPN11, BRAF, RAF1
kinase activity (GO:0016301)	2.93	3	PTPN11, BRAF, RAF1
cation binding (GO:0043169)	1.4	3	BRAF, KRAS, RAF1
enzyme binding (GO:0019899)	2.27	3	PTPN11, BRAF, RAF1
ion binding (GO:0043167)	1.36	3	BRAF, KRAS, RAF1
protein kinase binding (GO:0019901)	3.44	3	PTPN11, BRAF, RAF1
kinase binding (GO:0019900)	3.32	3	PTPN11, BRAF, RAF1
transferase activity (GO:0016740)	1.95	3	PTPN11, BRAF, RAF1
macromolecular complex binding (GO:0044877)	2.61	3	PTPN11, KRAS, NRAS
protein domain specific binding (GO:0019904)	3.32	3	PTPN11, KRAS, SOS1
nucleic acid binding (GO:0003676)	1.44	3	SOS2, SOS1, RAF1
protein complex binding (GO:0032403)	3.09	3	PTPN11, KRAS, NRAS
metal ion binding (GO:0046872)	1.41	3	BRAF, KRAS, RAF1
guanyl ribonucleotide binding (GO:0032561)	3.73	3	KRAS, RIT1, NRAS
GTP binding (GO:0005525)	3.78	3	KRAS, RIT1, NRAS
Rho guanyl-nucleotide exchange factor activity (GO:0005089)	5.37	2	SOS2, SOS1
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	SOS2, SOS1
protein serine/threonine kinase activity (GO:0004674)	3.64	2	BRAF, RAF1
adenyl nucleotide binding (GO:0030554)	2.4	2	BRAF, RAF1
receptor signaling protein activity (GO:0005057)	4.76	2	BRAF, RAF1
DNA binding (GO:0003677)	1.92	2	SOS2, SOS1
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	SOS2, SOS1
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	2	PTPN11, RAF1
small GTPase binding (GO:0031267)	4.13	2	BRAF, RAF1
GTPase binding (GO:0051020)	4.05	2	BRAF, RAF1
adenyl ribonucleotide binding (GO:0032559)	2.41	2	BRAF, RAF1
identical protein binding (GO:0042802)	2.63	2	BRAF, RAF1
signal transducer activity (GO:0004871)	2.28	2	BRAF, RAF1
receptor signaling protein serine/threonine kinase activity (GO:0004702)	5.23	2	BRAF, RAF1
mitogen-activated protein kinase kinase binding (GO:0031434)	6.97	2	BRAF, RAF1
protein kinase activity (GO:0004672)	3.27	2	BRAF, RAF1
molecular function regulator (GO:0098772)	2.51	2	SOS2, SOS1
MAP kinase kinase kinase activity (GO:0004709)	6.6	2	BRAF, RAF1
ATP binding (GO:0005524)	2.43	2	BRAF, RAF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	-	4.31	0.0	PTPN11, BRAF, SOS2, RAF1, SOS1
guanyl-nucleotide exchange factor activity (GO:0005085)	-	4.02	0.0	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
purine nucleoside binding (GO:0001883)	-	2.22	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
nucleoside binding (GO:0001882)	-	2.21	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
anion binding (GO:0043168)	NEW	4.17	0.02	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
signaling adaptor activity (GO:0035591)	NEW	5.43	0.0	PTPN11, KRAS, SOS1, NRAS
mitogen-activated protein kinase kinase binding (GO:0031434)	-	6.97	0.015	BRAF, RAF1
nucleotide binding (GO:0000166)	-	1.96	0.007	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
guanyl ribonucleotide binding (GO:0032561)	-	3.73	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
calcium ion binding (GO:0005509)	NEW	3.17	0.046	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
ribonucleoside binding (GO:0032549)	-	2.22	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
protein complex binding (GO:0032403)	-	3.09	0.007	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
purine nucleotide binding (GO:0017076)	-	2.19	0.002	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
GTP binding (GO:0005525)	-	3.78	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
SH3/SH2 adaptor activity (GO:0005070)	NEW	5.79	0.0	PTPN11, KRAS, SOS1, NRAS
nucleoside phosphate binding (GO:1901265)	-	1.96	0.007	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
kinase binding (GO:0019900)	-	3.32	0.006	PTPN11, BRAF, KRAS, SOS1, RAF1, LZTR1
protein phosphatase binding (GO:0019903)	NEW	4.93	0.001	PTPN11, KRAS, SOS1, RAF1
phosphatase binding (GO:0019902)	NEW	4.63	0.006	PTPN11, KRAS, SOS1, RAF1
binding, bridging (GO:0060090)	NEW	4.57	0.0	PTPN11, KRAS, RAF1, NRAS, SOS1
protein binding, bridging (GO:0030674)	NEW	4.68	0.0	PTPN11, KRAS, RAF1, NRAS, SOS1
carbohydrate derivative binding (GO:0097367)	-	2.03	0.006	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
guanyl nucleotide binding (GO:0019001)	-	3.73	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
calmodulin binding (GO:0005516)	NEW	4.55	0.008	BRAF, RAF1, SOS1, RIT1
receptor signaling protein serine/threonine kinase activity (GO:0004702)	-	5.23	0.034	BRAF, RAF1
purine ribonucleotide binding (GO:0032555)	-	2.2	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
protein heterodimerization activity (GO:0046982)	-	3.64	0.0	PTPN11, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
MAP kinase kinase kinase activity (GO:0004709)	-	6.6	0.004	BRAF, RAF1
purine ribonucleoside binding (GO:0032550)	-	2.22	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
ribonucleotide binding (GO:0032553)	-	2.19	0.001	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
biological regulation (GO:0065007)	0.39	9	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of biological process (GO:0050789)	0.45	9	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of cellular process (GO:0050794)	0.5	9	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
intracellular signal transduction (GO:0035556)	2.39	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
signal transduction (GO:0007165)	1.28	8	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of biological process (GO:0048518)	1.2	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of response to stimulus (GO:0048584)	2.18	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of response to stimulus (GO:0048583)	1.54	7	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
phosphorylation (GO:0016310)	2.63	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
positive regulation of signaling (GO:0023056)	2.41	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of signaling (GO:0023051)	1.72	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
positive regulation of cell communication (GO:0010647)	2.41	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of cell communication (GO:0010646)	1.73	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
single-organism process (GO:0044699)	0.48	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
cellular protein metabolic process (GO:0044267)	1.63	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
single-organism metabolic process (GO:0044710)	1.63	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
cellular macromolecule metabolic process (GO:0044260)	0.93	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
regulation of signal transduction (GO:0009966)	1.84	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
positive regulation of signal transduction (GO:0009967)	2.5	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
organic substance metabolic process (GO:0071704)	0.63	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
positive regulation of catalytic activity (GO:0043085)	2.4	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
positive regulation of molecular function (GO:0044093)	2.23	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of molecular function (GO:0065009)	1.78	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
developmental process (GO:0032502)	1.36	6	PTPN11, BRAF, KRAS, SOS1, RAF1, LZTR1
cellular process (GO:0009987)	0.26	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
regulation of catalytic activity (GO:0050790)	1.97	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
cellular protein modification process (GO:0006464)	1.79	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
macromolecule modification (GO:0043412)	1.73	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
protein modification process (GO:0036211)	1.79	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
single-organism cellular process (GO:0044763)	0.65	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
metabolic process (GO:0008152)	0.58	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
positive regulation of intracellular signal transduction (GO:1902533)	2.95	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of intracellular signal transduction (GO:1902531)	2.31	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
primary metabolic process (GO:0044238)	0.69	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
protein metabolic process (GO:0019538)	1.45	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
cellular metabolic process (GO:0044237)	0.69	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
macromolecule metabolic process (GO:0043170)	0.83	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
immune system process (GO:0002376)	2.29	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
phosphate-containing compound metabolic process (GO:0006796)	2.16	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
phosphorus metabolic process (GO:0006793)	2.15	6	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
positive regulation of cellular process (GO:0048522)	1.3	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of primary metabolic process (GO:0080090)	1.08	5	PTPN11, KRAS, LZTR1, RAF1, BRAF
regulation of metabolic process (GO:0019222)	1.02	5	PTPN11, KRAS, LZTR1, RAF1, BRAF
regulation of cellular metabolic process (GO:0031323)	1.07	5	LZTR1, KRAS, PTPN11, RAF1, BRAF
cell surface receptor signaling pathway (GO:0007166)	2.09	5	PTPN11, KRAS, RAF1, NRAS, SOS1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	5	PTPN11, KRAS, NRAS, RAF1, SOS1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	5	PTPN11, KRAS, RAF1, NRAS, SOS1
anatomical structure morphogenesis (GO:0009653)	2.53	5	PTPN11, KRAS, LZTR1, SOS1, BRAF
regulation of apoptotic process (GO:0042981)	2.5	5	BRAF, SOS2, RAF1, KRAS, SOS1
signal transduction by protein phosphorylation (GO:0023014)	3.79	5	BRAF, KRAS, NRAS, RAF1, SOS1
regulation of cell death (GO:0010941)	2.43	5	BRAF, KRAS, SOS2, RAF1, SOS1
MAPK cascade (GO:0000165)	3.91	5	BRAF, KRAS, RAF1, NRAS, SOS1
cellular component organization (GO:0016043)	1.24	5	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of programmed cell death (GO:0043067)	2.49	5	SOS2, KRAS, BRAF, RAF1, SOS1
regulation of immune system process (GO:0002682)	2.5	5	PTPN11, KRAS, RAF1, NRAS, SOS1
cellular component organization or biogenesis (GO:0071840)	1.22	5	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of biological quality (GO:0065008)	1.68	5	PTPN11, KRAS, BRAF, RAF1, SOS1
protein phosphorylation (GO:0006468)	2.89	5	BRAF, KRAS, NRAS, RAF1, SOS1
multicellular organismal process (GO:0032501)	1.45	5	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of macromolecule metabolic process (GO:0060255)	1.08	5	LZTR1, KRAS, PTPN11, RAF1, BRAF
single-organism developmental process (GO:0044767)	1.49	5	PTPN11, KRAS, BRAF, RAF1, SOS1
small GTPase mediated signal transduction (GO:0007264)	3.85	5	SOS2, KRAS, NRAS, SOS1, RIT1
regulation of immune response (GO:0050776)	2.98	5	PTPN11, KRAS, RAF1, NRAS, SOS1
single-multicellular organism process (GO:0044707)	1.78	5	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of response to stress (GO:0080134)	2.53	5	PTPN11, KRAS, RAF1, NRAS, BRAF
anatomical structure development (GO:0048856)	1.58	5	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of phosphate metabolic process (GO:0019220)	2.35	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of metabolic process (GO:0009893)	1.74	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of kinase activity (GO:0033674)	3.54	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	PTPN11, KRAS, BRAF, RAF1
cell differentiation (GO:0030154)	2.14	4	PTPN11, KRAS, BRAF, RAF1
regulation of Ras protein signal transduction (GO:0046578)	4.49	4	SOS2, KRAS, SOS1, RAF1
movement of cell or subcellular component (GO:0006928)	2.61	4	PTPN11, KRAS, SOS1, NRAS
homeostatic process (GO:0042592)	2.61	4	PTPN11, KRAS, SOS1, RAF1
leukocyte migration (GO:0050900)	4.19	4	PTPN11, KRAS, SOS1, NRAS
ERBB signaling pathway (GO:0038127)	5.36	4	PTPN11, KRAS, SOS1, NRAS
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	4	PTPN11, KRAS, BRAF, RAF1
regulation of defense response (GO:0031347)	3.11	4	PTPN11, KRAS, NRAS, RAF1
regulation of MAPK cascade (GO:0043408)	3.22	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of transferase activity (GO:0051347)	3.31	4	PTPN11, KRAS, BRAF, RAF1
immune response-regulating signaling pathway (GO:0002764)	3.72	4	KRAS, RAF1, NRAS, SOS1
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	4	KRAS, NRAS, RAF1, SOS1
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	PTPN11, KRAS, BRAF, RAF1
regulation of kinase activity (GO:0043549)	3.07	4	PTPN11, KRAS, BRAF, RAF1
regulation of protein metabolic process (GO:0051246)	1.93	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of protein metabolic process (GO:0051247)	2.43	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of immune system process (GO:0002684)	2.96	4	PTPN11, KRAS, NRAS, RAF1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	PTPN11, KRAS, BRAF, RAF1
regulation of protein modification process (GO:0031399)	2.32	4	PTPN11, KRAS, BRAF, RAF1
negative regulation of biological process (GO:0048519)	1.33	4	PTPN11, KRAS, BRAF, RAF1
cell migration (GO:0016477)	3.12	4	PTPN11, KRAS, SOS1, NRAS
regulation of gene expression (GO:0010468)	1.37	4	LZTR1, KRAS, BRAF, RAF1
regulation of cell proliferation (GO:0042127)	2.41	4	BRAF, KRAS, SOS1, RAF1
regulation of small GTPase mediated signal transduction (GO:0051056)	4.08	4	SOS2, KRAS, SOS1, RAF1
regulation of innate immune response (GO:0045088)	3.86	4	PTPN11, KRAS, NRAS, RAF1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	PTPN11, KRAS, BRAF, RAF1
regulation of protein kinase activity (GO:0045859)	3.15	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of MAPK cascade (GO:0043410)	3.57	4	PTPN11, KRAS, BRAF, RAF1
regulation of cell differentiation (GO:0045595)	2.42	4	BRAF, KRAS, SOS1, RAF1
epidermal growth factor receptor signaling pathway (GO:0007173)	5.72	4	PTPN11, KRAS, SOS1, NRAS
locomotion (GO:0040011)	2.91	4	PTPN11, KRAS, SOS1, NRAS
Ras protein signal transduction (GO:0007265)	4.76	4	KRAS, RIT1, NRAS, SOS1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	PTPN11, KRAS, BRAF, RAF1
regulation of phosphorylation (GO:0042325)	2.5	4	PTPN11, KRAS, BRAF, RAF1
regulation of phosphorus metabolic process (GO:0051174)	2.35	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of phosphorylation (GO:0042327)	2.9	4	PTPN11, KRAS, BRAF, RAF1
regulation of cellular protein metabolic process (GO:0032268)	1.99	4	PTPN11, KRAS, BRAF, RAF1
cell motility (GO:0048870)	3.02	4	PTPN11, KRAS, SOS1, NRAS
response to stimulus (GO:0050896)	1.22	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of protein modification process (GO:0031401)	2.7	4	PTPN11, KRAS, BRAF, RAF1
regulation of MAP kinase activity (GO:0043405)	3.95	4	PTPN11, KRAS, BRAF, RAF1
regulation of transferase activity (GO:0051338)	2.88	4	PTPN11, KRAS, BRAF, RAF1
regulation of protein phosphorylation (GO:0001932)	2.57	4	PTPN11, KRAS, BRAF, RAF1
cellular developmental process (GO:0048869)	1.82	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of protein kinase activity (GO:0045860)	3.61	4	PTPN11, KRAS, BRAF, RAF1
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	PTPN11, KRAS, BRAF, RAF1
negative regulation of cellular process (GO:0048523)	1.41	4	PTPN11, KRAS, BRAF, RAF1
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	LZTR1, KRAS, RAF1
regulation of cell adhesion (GO:0030155)	3.27	3	PTPN11, BRAF, SOS1
activation of protein kinase activity (GO:0032147)	4.08	3	PTPN11, BRAF, RAF1
regulation of cellular component organization (GO:0051128)	2.01	3	PTPN11, BRAF, RAF1
positive regulation of defense response (GO:0031349)	3.83	3	KRAS, RAF1, NRAS
negative regulation of signaling (GO:0023057)	2.65	3	PTPN11, BRAF, RAF1
positive regulation of gene expression (GO:0010628)	2.35	3	BRAF, KRAS, RAF1
negative regulation of cell communication (GO:0010648)	2.66	3	PTPN11, BRAF, RAF1
regulation of Rho protein signal transduction (GO:0035023)	5.02	3	SOS2, SOS1, RAF1
neurotrophin signaling pathway (GO:0038179)	6.55	3	PTPN11, SOS1, RAF1
ERBB2 signaling pathway (GO:0038128)	6.09	3	KRAS, SOS1, NRAS
establishment of localization (GO:0051234)	1.48	3	BRAF, RAF1, NRAS
activation of innate immune response (GO:0002218)	4.41	3	KRAS, NRAS, RAF1
axon guidance (GO:0007411)	4.44	3	KRAS, SOS1, NRAS
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	LZTR1, KRAS, RAF1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	LZTR1, KRAS, RAF1
negative regulation of apoptotic process (GO:0043066)	3.04	3	BRAF, KRAS, RAF1
regulation of localization (GO:0032879)	1.94	3	PTPN11, BRAF, RAF1
innate immune response activating cell surface receptor signaling pathway (GO:0002220)	5.07	3	KRAS, NRAS, RAF1
stimulatory C-type lectin receptor signaling pathway (GO:0002223)	5.09	3	KRAS, RAF1, NRAS
positive regulation of small GTPase mediated signal transduction (GO:0051057)	6.04	3	SOS2, KRAS, SOS1
regulation of cellular component biogenesis (GO:0044087)	3.08	3	PTPN11, BRAF, RAF1
positive regulation of innate immune response (GO:0045089)	4.22	3	KRAS, RAF1, NRAS
response to abiotic stimulus (GO:0009628)	2.8	3	BRAF, KRAS, RAF1
regulation of developmental process (GO:0050793)	2.1	3	PTPN11, BRAF, SOS1
negative regulation of cell death (GO:0060548)	2.95	3	BRAF, KRAS, RAF1
regulation of biosynthetic process (GO:0009889)	1.37	3	LZTR1, KRAS, RAF1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	LZTR1, KRAS, RAF1
establishment of protein localization (GO:0045184)	2.53	3	BRAF, NRAS, RAF1
cell activation (GO:0001775)	3.47	3	PTPN11, BRAF, RAF1
immune response-activating signal transduction (GO:0002757)	3.8	3	KRAS, RAF1, NRAS
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	3	LZTR1, KRAS, RAF1
regulation of multicellular organismal process (GO:0051239)	1.87	3	PTPN11, BRAF, SOS1
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	LZTR1, KRAS, RAF1
neurotrophin TRK receptor signaling pathway (GO:0048011)	6.96	3	PTPN11, SOS1, RAF1
neuron projection guidance (GO:0097485)	4.43	3	KRAS, SOS1, NRAS
localization (GO:0051179)	1.4	3	BRAF, RAF1, NRAS
Fc receptor signaling pathway (GO:0038093)	4.45	3	KRAS, SOS1, NRAS
regulation of hydrolase activity (GO:0051336)	2.53	3	SOS2, SOS1, RAF1
animal organ development (GO:0048513)	2.53	3	PTPN11, BRAF, RAF1
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	3	KRAS, RAF1, NRAS
homeostasis of number of cells (GO:0048872)	4.98	3	PTPN11, KRAS, SOS1
negative regulation of programmed cell death (GO:0043069)	3.02	3	BRAF, KRAS, RAF1
regulation of RNA metabolic process (GO:0051252)	1.52	3	LZTR1, KRAS, RAF1
innate immune response-activating signal transduction (GO:0002758)	4.45	3	KRAS, RAF1, NRAS
positive regulation of immune response (GO:0050778)	3.4	3	KRAS, RAF1, NRAS
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	LZTR1, KRAS, RAF1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	LZTR1, KRAS, RAF1
activation of immune response (GO:0002253)	3.67	3	KRAS, RAF1, NRAS
Fc-epsilon receptor signaling pathway (GO:0038095)	4.84	3	KRAS, SOS1, NRAS
developmental growth (GO:0048589)	4.05	2	PTPN11, SOS1
anatomical structure homeostasis (GO:0060249)	4.25	2	PTPN11, KRAS
negative regulation of secretion (GO:0051048)	4.44	2	PTPN11, BRAF
regulation of transport (GO:0051049)	2.24	2	PTPN11, BRAF
cell development (GO:0048468)	3.28	2	PTPN11, KRAS
behavior (GO:0007610)	3.47	2	BRAF, KRAS
learning or memory (GO:0007611)	4.33	2	BRAF, KRAS
regulation of neuron apoptotic process (GO:0043523)	4.47	2	BRAF, KRAS
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	BRAF, KRAS
face development (GO:0060324)	6.78	2	BRAF, RAF1
multicellular organism growth (GO:0035264)	5.37	2	PTPN11, SOS1
cellular response to stimulus (GO:0051716)	1.97	2	PTPN11, BRAF
regulation of secretion (GO:0051046)	3.2	2	PTPN11, BRAF
positive regulation of cell adhesion (GO:0045785)	3.79	2	PTPN11, BRAF
thymus development (GO:0048538)	5.88	2	BRAF, RAF1
negative regulation of transport (GO:0051051)	3.6	2	PTPN11, BRAF
regulation of protein complex assembly (GO:0043254)	3.83	2	PTPN11, RAF1
learning (GO:0007612)	4.85	2	BRAF, KRAS
response to organic substance (GO:0010033)	2.2	2	BRAF, KRAS
platelet activation (GO:0030168)	4.96	2	PTPN11, RAF1
system process (GO:0003008)	2.3	2	BRAF, KRAS
stem cell population maintenance (GO:0019827)	4.83	2	BRAF, RAF1
single organism reproductive process (GO:0044702)	2.73	2	PTPN11, SOS1
homeostasis of number of cells within a tissue (GO:0048873)	6.33	2	PTPN11, KRAS
single-organism behavior (GO:0044708)	3.79	2	BRAF, KRAS
chemical homeostasis (GO:0048878)	2.97	2	PTPN11, RAF1
negative regulation of secretion by cell (GO:1903531)	4.55	2	PTPN11, BRAF
visual behavior (GO:0007632)	5.82	2	BRAF, KRAS
cellular component assembly (GO:0022607)	2.14	2	BRAF, RAF1
regulation of synaptic plasticity (GO:0048167)	4.78	2	BRAF, KRAS
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	PTPN11, KRAS
positive regulation of GTPase activity (GO:0043547)	3.28	2	SOS2, SOS1
positive regulation of hydrolase activity (GO:0051345)	2.91	2	SOS2, SOS1
macromolecular complex assembly (GO:0065003)	2.55	2	BRAF, RAF1
thyroid gland development (GO:0030878)	6.47	2	BRAF, RAF1
organ morphogenesis (GO:0009887)	3.55	2	BRAF, SOS1
transport (GO:0006810)	1.51	2	BRAF, RAF1
maintenance of cell number (GO:0098727)	4.82	2	BRAF, RAF1
response to stress (GO:0006950)	1.8	2	PTPN11, RAF1
associative learning (GO:0008306)	5.44	2	BRAF, KRAS
somatic stem cell population maintenance (GO:0035019)	5.52	2	BRAF, RAF1
regulation of neuron death (GO:1901214)	4.19	2	BRAF, KRAS
negative regulation of neuron death (GO:1901215)	4.57	2	BRAF, KRAS
cognition (GO:0050890)	4.2	2	BRAF, KRAS
regulation of leukocyte activation (GO:0002694)	3.6	2	PTPN11, SOS1
regulation of cell motility (GO:2000145)	3.16	2	BRAF, RAF1
regulation of synapse structure or activity (GO:0050803)	4.77	2	BRAF, KRAS
response to radiation (GO:0009314)	3.69	2	BRAF, KRAS
modulation of synaptic transmission (GO:0050804)	4.09	2	BRAF, KRAS
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	PTPN11, KRAS
response to light stimulus (GO:0009416)	4.08	2	BRAF, KRAS
regulation of secretion by cell (GO:1903530)	3.28	2	PTPN11, BRAF
regulation of GTPase activity (GO:0043087)	3.21	2	SOS2, SOS1
visual learning (GO:0008542)	5.92	2	BRAF, KRAS
response to organic cyclic compound (GO:0014070)	3.07	2	BRAF, KRAS
response to endogenous stimulus (GO:0009719)	2.79	2	BRAF, KRAS
regulation of lymphocyte activation (GO:0051249)	3.73	2	PTPN11, SOS1
regulation of cell activation (GO:0050865)	3.53	2	PTPN11, SOS1
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	2	PTPN11, SOS1
neurological system process (GO:0050877)	2.64	2	BRAF, KRAS
regulation of cellular component movement (GO:0051270)	3.08	2	BRAF, RAF1
tissue homeostasis (GO:0001894)	4.78	2	PTPN11, KRAS
regulation of cell-cell adhesion (GO:0022407)	3.79	2	PTPN11, SOS1
response to hormone (GO:0009725)	3.33	2	BRAF, KRAS
gland development (GO:0048732)	4.15	2	BRAF, RAF1
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	2	PTPN11, BRAF
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	2	PTPN11, BRAF
activation of MAPKK activity (GO:0000186)	5.74	2	BRAF, RAF1
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	2	BRAF, RAF1
regulation of cellular localization (GO:0060341)	3.03	2	PTPN11, BRAF
macromolecular complex subunit organization (GO:0043933)	2.14	2	BRAF, RAF1
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	BRAF, RAF1
regulation of T cell activation (GO:0050863)	4.05	2	PTPN11, SOS1
glucose homeostasis (GO:0042593)	4.6	2	PTPN11, RAF1
positive regulation of cell death (GO:0010942)	3.32	2	SOS2, SOS1
morphogenesis of an epithelium (GO:0002009)	4.08	2	KRAS, SOS1
growth (GO:0040007)	3.8	2	PTPN11, SOS1
protein complex subunit organization (GO:0071822)	2.6	2	BRAF, RAF1
carbohydrate homeostasis (GO:0033500)	4.6	2	PTPN11, RAF1
positive regulation of apoptotic process (GO:0043065)	3.38	2	SOS2, SOS1
tissue morphogenesis (GO:0048729)	3.87	2	KRAS, SOS1
organic substance transport (GO:0071702)	2.15	2	BRAF, RAF1
hematopoietic or lymphoid organ development (GO:0048534)	4.49	2	BRAF, RAF1
positive regulation of programmed cell death (GO:0043068)	3.38	2	SOS2, SOS1
protein complex assembly (GO:0006461)	2.78	2	BRAF, RAF1
regulation of hormone levels (GO:0010817)	3.56	2	PTPN11, RAF1
reproductive process (GO:0022414)	2.55	2	PTPN11, SOS1
single-organism transport (GO:0044765)	2.18	2	BRAF, RAF1
response to chemical (GO:0042221)	1.98	2	BRAF, KRAS
single-organism localization (GO:1902578)	2.09	2	BRAF, RAF1
organelle organization (GO:0006996)	2.02	2	KRAS, RAF1
heart development (GO:0007507)	4.24	2	PTPN11, RAF1
regulation of locomotion (GO:0040012)	3.12	2	BRAF, RAF1
cytoskeleton organization (GO:0007010)	3.22	2	KRAS, RAF1
single-organism organelle organization (GO:1902589)	2.68	2	KRAS, RAF1
regulation of multicellular organismal development (GO:2000026)	2.31	2	BRAF, SOS1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hemostasis (GO:0007599)	NEW	4.5	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of response to stimulus (GO:0048584)	-	2.18	0.022	PTPN11, NRAS, BRAF, KRAS, SOS2, SOS1
learning (GO:0007612)	-	4.85	0.012	BRAF, KRAS, NRAS
activation of protein kinase activity (GO:0032147)	-	4.08	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
behavior (GO:0007610)	-	3.47	0.004	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
learning or memory (GO:0007611)	-	4.33	0.014	KRAS, PTPN11, SOS2, BRAF, NRAS
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.003	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of neuron apoptotic process (GO:0043523)	-	4.47	0.0	PTPN11, NRAS, BRAF, KRAS, RAF1, LZTR1
negative regulation of neuron apoptotic process (GO:0043524)	-	4.82	0.019	PTPN11, NRAS, BRAF, KRAS, RAF1, LZTR1
cell surface receptor signaling pathway (GO:0007166)	-	2.09	0.003	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
enzyme linked receptor protein signaling pathway (GO:0007167)	-	3.24	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	-	3.54	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleobase-containing compound catabolic process (GO:0034655)	NEW	3.9	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
glycerolipid metabolic process (GO:0046486)	NEW	3.91	0.026	PTPN11, KRAS, SOS2, RAF1, SOS1
signal transduction by phosphorylation (GO:0023014)	-	3.79	0.005	PTPN11, KRAS, RAF1, NRAS, BRAF
positive regulation of cell projection organization (GO:0031346)	NEW	3.99	0.024	PTPN11, KRAS, BRAF, RAF1, SOS1
neuron projection guidance (GO:0097485)	-	4.43	0.008	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
monosaccharide metabolic process (GO:0005996)	NEW	4.57	0.005	LZTR1, KRAS, BRAF, RAF1, SOS1
regulation of signal transduction (GO:0009966)	-	1.84	0.006	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of signal transduction (GO:0009967)	-	2.5	0.002	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
MAPK cascade (GO:0000165)	-	3.91	0.001	PTPN11, KRAS, RAF1, NRAS, BRAF
response to growth factor (GO:0070848)	NEW	4.14	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
Ras protein signal transduction (GO:0007265)	-	4.76	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.004	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular glucan metabolic process (GO:0006073)	NEW	5.65	0.032	PTPN11, BRAF, RAF1
positive regulation of small GTPase mediated signal transduction (GO:0051057)	-	6.04	0.0	SOS2, KRAS, SOS1, NRAS
regulation of small GTPase mediated signal transduction (GO:0051056)	-	4.08	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.004	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
blood coagulation (GO:0007596)	NEW	4.52	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
GTP metabolic process (GO:0046039)	NEW	6.59	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of protein kinase activity (GO:0045859)	-	3.15	0.018	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
epidermal growth factor receptor signaling pathway (GO:0007173)	-	5.72	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
positive regulation of neuron projection development (GO:0010976)	NEW	4.26	0.01	PTPN11, BRAF, RAF1, SOS1
response to peptide hormone (GO:0043434)	NEW	4.06	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.009	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to organic substance (GO:0010033)	-	2.2	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
platelet activation (GO:0030168)	-	4.96	0.004	PTPN11, KRAS, BRAF, RAF1, SOS1
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.009	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
negative regulation of phosphorylation (GO:0042326)	NEW	3.7	0.004	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
organonitrogen compound catabolic process (GO:1901565)	NEW	3.91	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
single-organism behavior (GO:0044708)	-	3.79	0.013	PTPN11, NRAS, BRAF, KRAS, SOS2, SOS1
response to organonitrogen compound (GO:0010243)	NEW	3.2	0.016	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
immune system process (GO:0002376)	-	2.29	0.045	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
response to hormone (GO:0009725)	-	3.33	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of cell morphogenesis (GO:0022604)	NEW	3.4	0.028	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
visual behavior (GO:0007632)	-	5.82	0.001	BRAF, KRAS, NRAS
cellular response to chemical stimulus (GO:0070887)	NEW	2.57	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of kinase activity (GO:0033674)	-	3.54	0.002	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.005	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.004	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular component movement (GO:0006928)	-	2.61	0.005	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
regulation of synaptic plasticity (GO:0048167)	-	4.78	0.013	PTPN11, KRAS, BRAF, NRAS
actin filament-based process (GO:0030029)	NEW	3.94	0.001	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
intracellular signal transduction (GO:0035556)	-	2.39	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of apoptotic process (GO:0042981)	-	2.5	0.005	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
neurotrophin signaling pathway (GO:0038179)	-	6.55	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine nucleotide metabolic process (GO:0006163)	NEW	4.09	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of transferase activity (GO:0051347)	-	3.31	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
immune response-regulating signaling pathway (GO:0002764)	-	3.72	0.011	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of kinase activity (GO:0043549)	-	3.07	0.007	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ribonucleotide metabolic process (GO:0009259)	NEW	4.11	0.014	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
guanosine-containing compound catabolic process (GO:1901069)	NEW	8.63	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
guanosine-containing compound metabolic process (GO:1901068)	NEW	5.9	0.0	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
energy reserve metabolic process (GO:0006112)	NEW	5.44	0.04	PTPN11, BRAF, RAF1, SOS1
positive regulation of catalytic activity (GO:0043085)	-	2.4	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of molecular function (GO:0065009)	-	1.78	0.017	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of cellular component organization (GO:0051130)	NEW	2.68	0.042	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of catalytic activity (GO:0050790)	-	1.97	0.005	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
hexose metabolic process (GO:0019318)	NEW	4.64	0.003	LZTR1, KRAS, BRAF, RAF1, SOS1
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.012	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
associative learning (GO:0008306)	-	5.44	0.002	BRAF, KRAS, NRAS
neurotrophin TRK receptor signaling pathway (GO:0048011)	-	6.96	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
negative regulation of neuron death (GO:1901215)	-	4.57	0.026	PTPN11, NRAS, BRAF, KRAS, RAF1, LZTR1
leukocyte differentiation (GO:0002521)	NEW	4.13	0.034	PTPN11, KRAS, LZTR1, SOS1, BRAF
glucan metabolic process (GO:0044042)	NEW	5.65	0.032	PTPN11, BRAF, RAF1
Fc-epsilon receptor signaling pathway (GO:0038095)	-	4.84	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
Fc receptor signaling pathway (GO:0038093)	-	4.45	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
response to nitrogen compound (GO:1901698)	NEW	3.12	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular response to nitrogen compound (GO:1901699)	NEW	3.79	0.001	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
cognition (GO:0050890)	-	4.2	0.026	PTPN11, SOS2, NRAS, KRAS, BRAF
regulation of transferase activity (GO:0051338)	-	2.88	0.002	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
coagulation (GO:0050817)	NEW	4.51	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside phosphate metabolic process (GO:0006753)	NEW	3.71	0.002	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.009	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to radiation (GO:0009314)	-	3.69	0.029	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
regulation of Ras protein signal transduction (GO:0046578)	-	4.49	0.011	PTPN11, KRAS, RAF1, NRAS, SOS1
regulation of synaptic transmission (GO:0050804)	-	4.09	0.029	PTPN11, KRAS, BRAF, NRAS, SOS1
positive regulation of signaling (GO:0023056)	-	2.41	0.002	PTPN11, NRAS, BRAF, KRAS, SOS2, SOS1
single-organism carbohydrate metabolic process (GO:0044723)	NEW	3.42	0.031	PTPN11, BRAF, KRAS, SOS1, RAF1, LZTR1
regulation of MAP kinase activity (GO:0043405)	-	3.95	0.037	PTPN11, KRAS, SOS2, RAF1, SOS1
regulation of Rac protein signal transduction (GO:0035020)	NEW	7.24	0.0	KRAS, SOS1, NRAS
ERBB signaling pathway (GO:0038127)	-	5.36	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
positive regulation of Rac protein signal transduction (GO:0035022)	NEW	8.63	0.001	KRAS, NRAS
regulation of signaling (GO:0023051)	-	1.72	0.014	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
axon guidance (GO:0007411)	-	4.44	0.008	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
positive regulation of cell communication (GO:0010647)	-	2.41	0.002	PTPN11, NRAS, BRAF, KRAS, SOS2, SOS1
regulation of cell communication (GO:0010646)	-	1.73	0.014	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of GTPase activity (GO:0043087)	-	3.21	0.028	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
visual learning (GO:0008542)	-	5.92	0.043	BRAF, KRAS, NRAS
negative regulation of MAPK cascade (GO:0043409)	NEW	4.74	0.001	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of MAPK cascade (GO:0043408)	-	3.22	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to endogenous stimulus (GO:0009719)	-	2.79	0.004	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
regulation of intracellular signal transduction (GO:1902531)	-	2.31	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular response to peptide hormone stimulus (GO:0071375)	NEW	4.63	0.001	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.015	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of anatomical structure morphogenesis (GO:0022603)	NEW	2.79	0.002	PTPN11, RIT1, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
positive regulation of protein metabolic process (GO:0051247)	-	2.43	0.011	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
epithelial tube branching involved in lung morphogenesis (GO:0060441)	NEW	6.9	0.025	KRAS, NRAS
positive regulation of cellular protein metabolic process (GO:0032270)	-	2.49	0.007	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
cellular response to endogenous stimulus (GO:0071495)	NEW	3.33	0.0	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
insulin receptor signaling pathway (GO:0008286)	NEW	5.33	0.0	PTPN11, KRAS, NRAS, RAF1, SOS1
positive regulation of molecular function (GO:0044093)	-	2.23	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of body fluid levels (GO:0050878)	NEW	3.76	0.004	PTPN11, NRAS, SOS1, SOS2, KRAS, RAF1, LZTR1
neurological system process (GO:0050877)	-	2.64	0.041	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of cell differentiation (GO:0045597)	NEW	3.01	0.018	PTPN11, RIT1, BRAF, SOS1, KRAS, RAF1, LZTR1
negative regulation of cell differentiation (GO:0045596)	NEW	3.33	0.047	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
cellular response to hormone stimulus (GO:0032870)	NEW	3.99	0.026	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
nucleobase-containing small molecule metabolic process (GO:0055086)	NEW	3.59	0.003	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular nitrogen compound catabolic process (GO:0044270)	NEW	3.8	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
negative regulation of developmental process (GO:0051093)	NEW	3.17	0.031	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
regulation of immune response (GO:0050776)	-	2.98	0.022	PTPN11, NRAS, SOS1, SOS2, KRAS, RAF1, LZTR1
cellular response to growth factor stimulus (GO:0071363)	NEW	4.27	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.012	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to drug (GO:0042493)	NEW	3.71	0.011	PTPN11, BRAF, KRAS, SOS1, RAF1, LZTR1
heterocycle catabolic process (GO:0046700)	NEW	3.82	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
system development (GO:0048731)	NEW	2.92	0.042	PTPN11, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
glucose metabolic process (GO:0006006)	NEW	4.94	0.032	LZTR1, BRAF, RAF1, SOS1
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.001	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
activation of MAPKK activity (GO:0000186)	-	5.74	0.0	BRAF, KRAS, NRAS, RAF1, SOS1
positive regulation of protein modification process (GO:0031401)	-	2.7	0.014	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of peptidyl-serine phosphorylation (GO:0033135)	-	4.98	0.01	PTPN11, KRAS, BRAF, RAF1
actin cytoskeleton organization (GO:0030036)	NEW	4.1	0.001	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
positive regulation of cell death (GO:0010942)	-	3.32	0.026	PTPN11, KRAS, SOS2, SOS1, RAF1, LZTR1
leukocyte migration (GO:0050900)	-	4.19	0.002	PTPN11, KRAS, SOS1, NRAS
cellular response to insulin stimulus (GO:0032869)	NEW	5.29	0.005	PTPN11, KRAS, RAF1, NRAS, SOS1
response to insulin (GO:0032868)	NEW	4.72	0.018	PTPN11, KRAS, RAF1, NRAS, SOS1
regulation of cell death (GO:0010941)	-	2.43	0.007	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
regulation of phosphate metabolic process (GO:0019220)	-	2.35	0.002	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
regulation of long-term neuronal synaptic plasticity (GO:0048169)	NEW	6.55	0.045	KRAS, NRAS
cellular response to organonitrogen compound (GO:0071417)	NEW	3.87	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
regulation of programmed cell death (GO:0043067)	-	2.49	0.005	NRAS, BRAF, KRAS, SOS2, SOS1, RAF1
positive regulation of apoptotic process (GO:0043065)	-	3.38	0.015	PTPN11, KRAS, SOS2, SOS1, RAF1, LZTR1
cellular response to organic substance (GO:0071310)	NEW	2.78	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
tissue morphogenesis (GO:0048729)	-	3.87	0.008	PTPN11, NRAS, KRAS, SOS2, SOS1, LZTR1
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.002	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of programmed cell death (GO:0043068)	-	3.38	0.016	PTPN11, KRAS, SOS2, SOS1, RAF1, LZTR1
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.015	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
negative regulation of phosphate metabolic process (GO:0045936)	NEW	3.45	0.011	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
innate immune response (GO:0045087)	NEW	3.55	0.008	PTPN11, NRAS, SOS1, SOS2, KRAS, RAF1, LZTR1
regulation of phosphorus metabolic process (GO:0051174)	-	2.35	0.002	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleotide metabolic process (GO:0009117)	NEW	3.73	0.002	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
nucleoside metabolic process (GO:0009116)	NEW	4.12	0.013	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to chemical (GO:0042221)	-	1.98	0.004	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.011	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
small GTPase mediated signal transduction (GO:0007264)	-	3.85	0.0	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
positive regulation of GTPase activity (GO:0043547)	-	3.28	0.017	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
response to oxygen-containing compound (GO:1901700)	NEW	2.57	0.003	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
cellular response to oxygen-containing compound (GO:1901701)	NEW	3.22	0.006	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
negative regulation of locomotion (GO:0040013)	NEW	4.22	0.02	PTPN11, KRAS, BRAF, RAF1, SOS1
cytoskeleton organization (GO:0007010)	-	3.22	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
glycogen metabolic process (GO:0005977)	NEW	5.67	0.031	PTPN11, BRAF, RAF1
negative regulation of phosphorus metabolic process (GO:0010563)	NEW	3.45	0.011	PTPN11, NRAS, BRAF, KRAS, SOS1, RAF1
ribose phosphate metabolic process (GO:0019693)	NEW	4.06	0.015	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
glycosyl compound metabolic process (GO:1901657)	NEW	4.04	0.016	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
response to peptide (GO:1901652)	NEW	3.94	0.0	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
cellular response to peptide (GO:1901653)	NEW	4.52	0.0	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	-	3.96	0.003	PTPN11, NRAS, KRAS, SOS2, SOS1, RAF1
negative regulation of protein phosphorylation (GO:0001933)	NEW	3.79	0.041	PTPN11, KRAS, BRAF, RAF1, SOS1
regulation of protein phosphorylation (GO:0001932)	-	2.57	0.026	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
positive regulation of protein phosphorylation (GO:0001934)	-	2.95	0.004	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.003	RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	9	PTPN11, RIT1, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
intracellular part (GO:0044424)	0.28	8	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
cytoplasmic part (GO:0044444)	0.82	8	PTPN11, NRAS, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
intracellular organelle (GO:0043229)	0.51	7	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
organelle (GO:0043226)	0.4	7	PTPN11, NRAS, BRAF, SOS1, KRAS, RAF1, LZTR1
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	PTPN11, NRAS, BRAF, KRAS, RAF1, LZTR1
cytosol (GO:0005829)	1.68	6	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
membrane (GO:0016020)	0.68	6	RIT1, NRAS, BRAF, KRAS, SOS1, RAF1
intracellular (GO:0005622)	2.37	6	RIT1, NRAS, KRAS, SOS2, SOS1, RAF1
plasma membrane (GO:0005886)	1.39	6	RIT1, NRAS, BRAF, KRAS, SOS1, RAF1
membrane-bounded organelle (GO:0043227)	0.47	6	PTPN11, NRAS, BRAF, KRAS, RAF1, LZTR1
cytoplasm (GO:0005737)	1.01	4	PTPN11, KRAS, BRAF, RAF1
mitochondrion (GO:0005739)	2.42	4	PTPN11, KRAS, BRAF, RAF1
Golgi apparatus (GO:0005794)	2.7	3	LZTR1, RAF1, NRAS
nucleus (GO:0005634)	1.07	3	PTPN11, BRAF, RAF1
organelle membrane (GO:0031090)	1.97	2	RAF1, NRAS
bounding membrane of organelle (GO:0098588)	2.39	2	RAF1, NRAS
cell body (GO:0044297)	3.74	2	BRAF, SOS1
intracellular organelle part (GO:0044446)	0.81	2	RAF1, NRAS
neuron part (GO:0097458)	2.64	2	BRAF, SOS1
cell projection (GO:0042995)	2.47	2	BRAF, RAF1
organelle part (GO:0044422)	0.79	2	RAF1, NRAS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Golgi apparatus (GO:0005794)	-	2.7	0.042	PTPN11, KRAS, SOS2, SOS1, RAF1, LZTR1
catalytic complex (GO:1902494)	NEW	2.9	0.001	PTPN11, BRAF, SOS1, SOS2, KRAS, RAF1, LZTR1
cell-substrate junction (GO:0030055)	NEW	3.82	0.006	PTPN11, KRAS, BRAF, RAF1, SOS1
protein kinase complex (GO:1902911)	NEW	5.31	0.009	BRAF, KRAS, RAF1
anchoring junction (GO:0070161)	NEW	3.61	0.016	PTPN11, KRAS, BRAF, RAF1, SOS1
adherens junction (GO:0005912)	NEW	3.66	0.013	PTPN11, KRAS, BRAF, RAF1, SOS1
transferase complex (GO:1990234)	NEW	3.32	0.001	PTPN11, BRAF, KRAS, SOS2, SOS1, RAF1
cell-substrate adherens junction (GO:0005924)	NEW	3.83	0.006	PTPN11, KRAS, BRAF, RAF1, SOS1
focal adhesion (GO:0005925)	NEW	3.83	0.005	PTPN11, KRAS, BRAF, RAF1, SOS1
endoplasmic reticulum (GO:0005783)	NEW	2.56	0.047	PTPN11, BRAF, KRAS, SOS1, RAF1, LZTR1