| Disease ID | Disease name | Source of annotation with SOS2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS163950 | NOONAN SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 9 | LZTR1, BRAF, RIT1, NRAS, KRAS, SOS2, PTPN11, SOS1, RAF1 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| FoxO signaling pathway | hsa04068 | 5.63 |
| Natural killer cell mediated cytotoxicity | hsa04650 | 5.53 |
| Renal cell carcinoma | hsa05211 | 6.6 |
| Glioma | hsa05214 | 6.66 |
| Jak-STAT signaling pathway | hsa04630 | 5.44 |
| Neurotrophin signaling pathway | hsa04722 | 5.78 |
| Choline metabolism in cancer | hsa05231 | 6.09 |
| Focal adhesion | hsa04510 | 4.92 |
| Chemokine signaling pathway | hsa04062 | 5.19 |
| Endometrial cancer | hsa05213 | 6.81 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| Hepatitis C | hsa05160 | 5.68 |
| Gap junction | hsa04540 | 6.24 |
| Proteoglycans in cancer | hsa05205 | 5.02 |
| Estrogen signaling pathway | hsa04915 | 6.11 |
| MicroRNAs in cancer | hsa05206 | 5.38 |
| Pathways in cancer | hsa05200 | 3.98 |
| GnRH signaling pathway | hsa04912 | 6.18 |
| Insulin signaling pathway | hsa04910 | 5.55 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Fc epsilon RI signaling pathway | hsa04664 | 6.6 |
| Prolactin signaling pathway | hsa04917 | 6.6 |
| Acute myeloid leukemia | hsa05221 | 6.74 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| Prostate cancer | hsa05215 | 6.11 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| T cell receptor signaling pathway | hsa04660 | 6.01 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| B cell receptor signaling pathway | hsa04662 | 6.52 |
| Dorso-ventral axis formation | hsa04320 | 8.01 |
| Alcoholism | hsa05034 | 5.59 |
| Non-small cell lung cancer | hsa05223 | 6.88 |
| ErbB signaling pathway | hsa04012 | 6.15 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Cell death signalling via NRAGE, NRIF and NADE | R-HSA-204998 | 7.05 |
| Signaling by Robo receptor | R-HSA-376176 | 7.98 |
| Activation of Rac | R-HSA-428540 | 9.18 |
| Signalling by NGF | R-HSA-166520 | 4.23 |
| G alpha (12/13) signalling events | R-HSA-416482 | 6.75 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| Rho GTPase cycle | R-HSA-194840 | 6.04 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| p75 NTR receptor-mediated signalling | R-HSA-193704 | 6.59 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Axon guidance | R-HSA-422475 | 3.93 |
| Developmental Biology | R-HSA-1266738 | 3.48 |
| NRAGE signals death through JNK | R-HSA-193648 | 7.49 |
| GO term | GO ID | GO IC |
|---|---|---|
| Rho guanyl-nucleotide exchange factor activity | GO:0005089 | 5.37 |
| Ras guanyl-nucleotide exchange factor activity | GO:0005088 | 4.31 |
| protein heterodimerization activity | GO:0046982 | 3.64 |
| nucleic acid binding | GO:0003676 | 1.44 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| DNA binding | GO:0003677 | 1.92 |
| protein dimerization activity | GO:0046983 | 2.72 |
| molecular function regulator | GO:0098772 | 2.51 |
| heterocyclic compound binding | GO:1901363 | 1.06 |