Disease ID | Disease name | Source of annotation with TSHR | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS275200 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 5 | PAX8, THRA, NKX2-5, TSHB, TSHR |
603373 | HYPERTHYROIDISM, FAMILIAL GESTATIONAL | OMIM, HUMSAVAR | link to OMIM | 1 | TSHR |
609152 | HYPERTHYROIDISM, NONAUTOIMMUNE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | TSHR |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Thyroid hormone synthesis | hsa04918 | 6.56 |
Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
Autoimmune thyroid disease | hsa05320 | 6.62 |
cAMP signaling pathway | hsa04024 | 5.05 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Hormone ligand-binding receptors | R-HSA-375281 | 9.52 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
G alpha (s) signalling events | R-HSA-418555 | 5.99 |
Signal Transduction | R-HSA-162582 | 1.78 |
GO term | GO ID | GO IC |
---|---|---|
G-protein coupled peptide receptor activity | GO:0008528 | 4.86 |
G-protein coupled receptor activity | GO:0004930 | 2.95 |
signaling receptor activity | GO:0038023 | 2.49 |
protein binding | GO:0005515 | 0.46 |
molecular transducer activity | GO:0060089 | 2.32 |
transmembrane signaling receptor activity | GO:0004888 | 2.57 |
peptide receptor activity | GO:0001653 | 4.84 |
receptor activity | GO:0004872 | 2.32 |
signal transducer activity | GO:0004871 | 2.28 |
thyroid-stimulating hormone receptor activity | GO:0004996 | 9.05 |
protein-hormone receptor activity | GO:0016500 | 7.17 |
transmembrane receptor activity | GO:0099600 | 2.53 |
binding | GO:0005488 | 0.18 |