Gene table of TSHR : thyroid stimulating hormone receptor

Gene-disease associations table

Disease IDDisease nameSource of annotation with TSHROMIM linkNumber of associated genesgenes
PS275200HYPOTHYROIDISM, CONGENITAL, NONGOITROUSClinVar, OMIM, HUMSAVAR link to OMIM 5PAX8, THRA, NKX2-5, TSHB, TSHR
603373HYPERTHYROIDISM, FAMILIAL GESTATIONALOMIM, HUMSAVAR link to OMIM 1TSHR
609152HYPERTHYROIDISM, NONAUTOIMMUNEClinVar, OMIM, HUMSAVAR link to OMIM 1TSHR

Download the gene annotation in CSV format

Annotation of the gene TSHR

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Thyroid hormone synthesishsa049186.56
Neuroactive ligand-receptor interactionhsa040804.58
Autoimmune thyroid diseasehsa053206.62
cAMP signaling pathwayhsa040245.05
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Hormone ligand-binding receptorsR-HSA-3752819.52
Signaling by GPCRR-HSA-3727902.68
GPCR downstream signalingR-HSA-3883963.07
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.69
GPCR ligand bindingR-HSA-5007924.19
G alpha (s) signalling eventsR-HSA-4185555.99
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
G-protein coupled peptide receptor activityGO:00085284.86
G-protein coupled receptor activityGO:00049302.95
signaling receptor activityGO:00380232.49
protein bindingGO:00055150.46
molecular transducer activityGO:00600892.32
transmembrane signaling receptor activityGO:00048882.57
peptide receptor activityGO:00016534.84
receptor activityGO:00048722.32
signal transducer activityGO:00048712.28
thyroid-stimulating hormone receptor activityGO:00049969.05
protein-hormone receptor activityGO:00165007.17
transmembrane receptor activityGO:00996002.53
bindingGO:00054880.18