Disease table of HYPOTHYROIDISM, CONGENITAL, NONGOITROUS OMIM ID: PS275200

Gene-disease associations table

GeneAssociated with HYPOTHYROIDISM, CONGENITAL, NONGOITROUS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TSHRClinVar, OMIM, HUMSAVARHGNC link14q31.13PS275200, 603373, 609152
TSHBClinVar, OMIMHGNC link1p13.21PS275200
THRAClinVar, OMIM, HUMSAVARHGNC link17q21.11PS275200
PAX8ClinVar, OMIM, HUMSAVARHGNC link2q14.11PS275200
NKX2-5ClinVar, OMIM, HUMSAVARHGNC link5q35.17217095, PS614429, PS241550, PS108800, PS275200, 187500, 271400

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
THRAYES2SERPINC1, CGA0
PAX8YES7WT1, TG, TP53, TSHR, SLC5A5, E2F1, NCAM11TSHR
NKX2-5YES9DACT2, DACT1, GATA4, TBX5, DACT3, NPPB, CTNNB1, MEF2C, LYL10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TSHRYES2PAX8, PPARG1PAX8
TSHBYES3GATA2, LHX2, POU1F10
NKX2-5YES1GATA40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
THRAPAX8No1EP300

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TSHRTSHBYesactivation, binding1CGA
TSHRPAX8No-1NKX2-1
THRAPAX8No-3EP300, RXRG, PPARG
PAX8NKX2-5No-1BCL2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Thyroid hormone synthesishsa049186.563TSHB, PAX8, TSHR
Neuroactive ligand-receptor interactionhsa040804.583TSHR, TSHB, THRA
Autoimmune thyroid diseasehsa053206.622TSHB, TSHR

NET-GE enrichment

Term New enriched termICP valueGenes
Autoimmune thyroid disease (hsa05320) -6.620.011TSHR, TSHB
Neuroactive ligand-receptor interaction (hsa04080) -4.580.005TSHR, TSHB, THRA
Thyroid hormone synthesis (hsa04918) -6.560.0TSHB, PAX8, TSHR
Endocrine systemNEW3.260.013NKX2-5, TSHB, TSHR, THRA, PAX8
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Hormone ligand-binding receptorsR-HSA-3752819.522TSHR, TSHB
Signaling by GPCRR-HSA-3727902.682TSHB, TSHR
Generic Transcription PathwayR-HSA-2124363.862NKX2-5, THRA
Gene ExpressionR-HSA-741602.722NKX2-5, THRA
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692TSHR, TSHB
GPCR downstream signalingR-HSA-3883963.072TSHR, TSHB
GPCR ligand bindingR-HSA-5007924.192TSHB, TSHR
G alpha (s) signalling eventsR-HSA-4185555.992TSHB, TSHR
Signal TransductionR-HSA-1625821.782TSHB, TSHR

NET-GE enrichment

Term New enriched termICP valueGenes
Hormone ligand-binding receptors (R-HSA-375281) -9.520.0TSHR, TSHB
Amine-derived hormones (R-HSA-209776) NEW8.980.01TSHR, TSHB
Thyroxine biosynthesis (R-HSA-209968) NEW9.980.001TSHB, TSHR
Peptide hormone biosynthesis (R-HSA-209952) NEW9.40.002TSHB, TSHR
TCF dependent signaling in response to WNT (R-HSA-201681) NEW5.360.034TSHR, PAX8, NKX2-5
G alpha (s) signalling events (R-HSA-418555) -5.990.029TSHR, TSHB
Glycoprotein hormones (R-HSA-209822) NEW9.660.001TSHB, TSHR
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185THRA, TSHR, TSHB, NKX2-5, PAX8
protein binding (GO:0005515) 0.465THRA, TSHR, TSHB, NKX2-5, PAX8
sequence-specific DNA binding (GO:0043565) 2.793PAX8, NKX2-5, THRA
sequence-specific double-stranded DNA binding (GO:1990837) 3.23PAX8, NKX2-5, THRA
signaling receptor activity (GO:0038023) 2.493TSHR, PAX8, THRA
nucleic acid binding (GO:0003676) 1.443PAX8, NKX2-5, THRA
transcription regulatory region DNA binding (GO:0044212) 3.033PAX8, THRA, NKX2-5
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653PAX8, NKX2-5, THRA
organic cyclic compound binding (GO:0097159) 1.053PAX8, THRA, NKX2-5
regulatory region DNA binding (GO:0000975) 3.033PAX8, THRA, NKX2-5
regulatory region nucleic acid binding (GO:0001067) 3.033PAX8, THRA, NKX2-5
molecular transducer activity (GO:0060089) 2.323TSHR, PAX8, THRA
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.243PAX8, THRA, NKX2-5
nucleic acid binding transcription factor activity (GO:0001071) 2.653PAX8, NKX2-5, THRA
signal transducer activity (GO:0004871) 2.283TSHR, PAX8, THRA
DNA binding (GO:0003677) 1.923PAX8, THRA, NKX2-5
double-stranded DNA binding (GO:0003690) 3.093PAX8, THRA, NKX2-5
heterocyclic compound binding (GO:1901363) 1.063PAX8, THRA, NKX2-5
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.293PAX8, THRA, NKX2-5
receptor activity (GO:0004872) 2.323TSHR, PAX8, THRA
G-protein coupled receptor activity (GO:0004930) 2.952TSHR, PAX8
protein heterodimerization activity (GO:0046982) 3.642NKX2-5, THRA
thyroid-stimulating hormone receptor activity (GO:0004996) 9.052TSHR, PAX8
protein dimerization activity (GO:0046983) 2.722THRA, NKX2-5
transcription factor binding (GO:0008134) 3.462NKX2-5, THRA
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362PAX8, NKX2-5
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982PAX8, NKX2-5
core promoter proximal region DNA binding (GO:0001159) 3.822PAX8, NKX2-5
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232NKX2-5, THRA
transmembrane signaling receptor activity (GO:0004888) 2.572TSHR, PAX8
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) 4.312PAX8, NKX2-5
macromolecular complex binding (GO:0044877) 2.612THRA, NKX2-5
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372PAX8, NKX2-5
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832PAX8, NKX2-5
transmembrane receptor activity (GO:0099600) 2.532TSHR, PAX8
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882PAX8, NKX2-5
chromatin binding (GO:0003682) 3.642THRA, NKX2-5
protein-hormone receptor activity (GO:0016500) 7.172TSHR, PAX8
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.942PAX8, NKX2-5
identical protein binding (GO:0042802) 2.632NKX2-5, THRA
protein homodimerization activity (GO:0042803) 3.162THRA, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) -2.790.002TSHR, TSHB, THRA, NKX2-5, PAX8
transcription regulatory region DNA binding (GO:0044212) -3.030.013PAX8, NKX2-5, THRA
protein binding transcription factor activity (GO:0000988) NEW3.350.041THRA, TSHB, PAX8, NKX2-5
regulatory region nucleic acid binding (GO:0001067) -3.030.014PAX8, THRA, NKX2-5
transcription cofactor activity (GO:0003712) NEW3.440.034THRA, TSHB, PAX8, NKX2-5
zinc ion binding (GO:0008270) NEW2.660.048NKX2-5, TSHR, TSHB, THRA, PAX8
transcription factor binding transcription factor activity (GO:0000989) NEW3.360.041TSHB, PAX8, THRA, NKX2-5
regulatory region DNA binding (GO:0000975) -3.030.014PAX8, NKX2-5, THRA
receptor binding (GO:0005102) NEW2.430.047NKX2-5, TSHB, TSHR, THRA, PAX8
protein-hormone receptor activity (GO:0016500) -7.170.0TSHR, PAX8
thyroid-stimulating hormone receptor activity (GO:0004996) -9.050.0TSHR, PAX8
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.365THRA, TSHB, TSHR, NKX2-5, PAX8
cellular process (GO:0009987) 0.265NKX2-5, TSHB, TSHR, THRA, PAX8
regulation of cellular process (GO:0050794) 0.55NKX2-5, TSHR, TSHB, THRA, PAX8
single-organism cellular process (GO:0044763) 0.655THRA, TSHR, TSHB, NKX2-5, PAX8
signal transduction (GO:0007165) 1.285TSHR, TSHB, THRA, NKX2-5, PAX8
biological regulation (GO:0065007) 0.395THRA, TSHB, TSHR, NKX2-5, PAX8
anatomical structure morphogenesis (GO:0009653) 2.535THRA, TSHR, TSHB, NKX2-5, PAX8
regulation of biological process (GO:0050789) 0.455NKX2-5, TSHB, TSHR, THRA, PAX8
single-organism process (GO:0044699) 0.485THRA, TSHB, TSHR, NKX2-5, PAX8
positive regulation of metabolic process (GO:0009893) 1.744TSHR, PAX8, THRA, NKX2-5
regulation of metabolic process (GO:0019222) 1.024THRA, TSHR, PAX8, NKX2-5
positive regulation of biosynthetic process (GO:0009891) 2.294TSHR, PAX8, THRA, NKX2-5
regulation of cellular biosynthetic process (GO:0031326) 1.384THRA, TSHR, PAX8, NKX2-5
positive regulation of cellular metabolic process (GO:0031325) 1.814THRA, TSHR, PAX8, NKX2-5
cell differentiation (GO:0030154) 2.144TSHR, PAX8, THRA, NKX2-5
regulation of developmental process (GO:0050793) 2.14TSHR, PAX8, THRA, NKX2-5
metabolic process (GO:0008152) 0.584THRA, TSHB, PAX8, NKX2-5
cellular nitrogen compound metabolic process (GO:0034641) 1.224THRA, TSHB, PAX8, NKX2-5
nitrogen compound metabolic process (GO:0006807) 1.134TSHB, PAX8, THRA, NKX2-5
regulation of primary metabolic process (GO:0080090) 1.084THRA, TSHR, PAX8, NKX2-5
cellular developmental process (GO:0048869) 1.824TSHR, PAX8, THRA, NKX2-5
positive regulation of cellular biosynthetic process (GO:0031328) 2.34THRA, TSHR, PAX8, NKX2-5
organic substance metabolic process (GO:0071704) 0.634TSHB, PAX8, THRA, NKX2-5
positive regulation of biological process (GO:0048518) 1.24TSHR, PAX8, THRA, NKX2-5
multicellular organismal process (GO:0032501) 1.454THRA, TSHR, PAX8, NKX2-5
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354TSHR, PAX8, THRA, NKX2-5
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434TSHR, PAX8, THRA, NKX2-5
regulation of cellular metabolic process (GO:0031323) 1.074TSHR, PAX8, THRA, NKX2-5
regulation of biosynthetic process (GO:0009889) 1.374TSHR, PAX8, THRA, NKX2-5
single-organism developmental process (GO:0044767) 1.494TSHR, PAX8, THRA, NKX2-5
regulation of nitrogen compound metabolic process (GO:0051171) 1.364TSHR, PAX8, THRA, NKX2-5
regulation of multicellular organismal process (GO:0051239) 1.874TSHR, PAX8, THRA, NKX2-5
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294THRA, TSHR, PAX8, NKX2-5
primary metabolic process (GO:0044238) 0.694THRA, TSHB, PAX8, NKX2-5
single-multicellular organism process (GO:0044707) 1.784TSHR, PAX8, THRA, NKX2-5
positive regulation of developmental process (GO:0051094) 2.774TSHR, PAX8, THRA, NKX2-5
anatomical structure development (GO:0048856) 1.584THRA, TSHR, PAX8, NKX2-5
cellular metabolic process (GO:0044237) 0.694THRA, TSHB, PAX8, NKX2-5
macromolecule metabolic process (GO:0043170) 0.834TSHB, PAX8, THRA, NKX2-5
positive regulation of cellular process (GO:0048522) 1.34TSHR, PAX8, THRA, NKX2-5
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563PAX8, NKX2-5, THRA
RNA biosynthetic process (GO:0032774) 1.843PAX8, THRA, NKX2-5
regulation of transport (GO:0051049) 2.243PAX8, THRA, NKX2-5
regulation of cellular component organization (GO:0051128) 2.013PAX8, THRA, NKX2-5
nucleic acid metabolic process (GO:0090304) 1.463PAX8, THRA, NKX2-5
cellular biosynthetic process (GO:0044249) 1.373PAX8, NKX2-5, THRA
positive regulation of gene expression (GO:0010628) 2.353PAX8, NKX2-5, THRA
cellular component organization (GO:0016043) 1.243TSHR, PAX8, NKX2-5
cellular macromolecule biosynthetic process (GO:0034645) 1.663PAX8, THRA, NKX2-5
regulation of signaling (GO:0023051) 1.723PAX8, THRA, NKX2-5
regulation of cell differentiation (GO:0045595) 2.423PAX8, THRA, NKX2-5
regulation of cell communication (GO:0010646) 1.733PAX8, NKX2-5, THRA
organic cyclic compound biosynthetic process (GO:1901362) 1.663PAX8, NKX2-5, THRA
cellular component organization or biogenesis (GO:0071840) 1.223TSHR, PAX8, NKX2-5
nucleobase-containing compound metabolic process (GO:0006139) 1.353PAX8, NKX2-5, THRA
regulation of cell death (GO:0010941) 2.433PAX8, THRA, NKX2-5
positive regulation of macromolecule metabolic process (GO:0010604) 1.813PAX8, THRA, NKX2-5
cellular macromolecule metabolic process (GO:0044260) 0.933PAX8, THRA, NKX2-5
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243PAX8, THRA, NKX2-5
regulation of apoptotic process (GO:0042981) 2.53PAX8, NKX2-5, THRA
positive regulation of multicellular organismal process (GO:0051240) 2.493TSHR, PAX8, NKX2-5
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463PAX8, NKX2-5, THRA
nucleic acid-templated transcription (GO:0097659) 1.913PAX8, THRA, NKX2-5
regulation of programmed cell death (GO:0043067) 2.493PAX8, THRA, NKX2-5
animal organ development (GO:0048513) 2.533PAX8, THRA, NKX2-5
organic cyclic compound metabolic process (GO:1901360) 1.263PAX8, THRA, NKX2-5
transcription from RNA polymerase II promoter (GO:0006366) 3.383PAX8, THRA, NKX2-5
negative regulation of biological process (GO:0048519) 1.333PAX8, NKX2-5, THRA
regulation of biological quality (GO:0065008) 1.683TSHB, PAX8, THRA
G-protein coupled receptor signaling pathway (GO:0007186) 2.643TSHR, TSHB, PAX8
regulation of gene expression (GO:0010468) 1.373PAX8, NKX2-5, THRA
heterocycle biosynthetic process (GO:0018130) 1.73PAX8, NKX2-5, THRA
embryonic morphogenesis (GO:0048598) 3.723TSHR, PAX8, NKX2-5
organic substance biosynthetic process (GO:1901576) 1.343PAX8, THRA, NKX2-5
regulation of macromolecule metabolic process (GO:0060255) 1.083PAX8, THRA, NKX2-5
cellular aromatic compound metabolic process (GO:0006725) 1.33PAX8, THRA, NKX2-5
regulation of nucleic acid-templated transcription (GO:1903506) 1.553PAX8, THRA, NKX2-5
positive regulation of cell differentiation (GO:0045597) 3.013PAX8, NKX2-5, THRA
biosynthetic process (GO:0009058) 1.323PAX8, NKX2-5, THRA
macromolecule biosynthetic process (GO:0009059) 1.613PAX8, THRA, NKX2-5
positive regulation of transcription, DNA-templated (GO:0045893) 2.563PAX8, NKX2-5, THRA
regulation of RNA biosynthetic process (GO:2001141) 1.553PAX8, THRA, NKX2-5
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723PAX8, THRA, NKX2-5
response to chemical (GO:0042221) 1.983TSHB, PAX8, THRA
tube development (GO:0035295) 4.413PAX8, THRA, NKX2-5
regulation of localization (GO:0032879) 1.943PAX8, THRA, NKX2-5
heterocycle metabolic process (GO:0046483) 1.313PAX8, NKX2-5, THRA
RNA metabolic process (GO:0016070) 1.593PAX8, NKX2-5, THRA
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593PAX8, THRA, NKX2-5
aromatic compound biosynthetic process (GO:0019438) 1.73PAX8, NKX2-5, THRA
thyroid gland development (GO:0030878) 6.473PAX8, NKX2-5, THRA
response to stimulus (GO:0050896) 1.223TSHB, PAX8, THRA
regulation of RNA metabolic process (GO:0051252) 1.523PAX8, NKX2-5, THRA
positive regulation of RNA metabolic process (GO:0051254) 2.513PAX8, NKX2-5, THRA
positive regulation of RNA biosynthetic process (GO:1902680) 2.543PAX8, NKX2-5, THRA
regulation of transcription, DNA-templated (GO:0006355) 1.563PAX8, THRA, NKX2-5
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393PAX8, THRA, NKX2-5
regulation of macromolecule biosynthetic process (GO:0010556) 1.433PAX8, THRA, NKX2-5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813PAX8, NKX2-5, THRA
transcription, DNA-templated (GO:0006351) 1.913PAX8, NKX2-5, THRA
system development (GO:0048731) 2.923TSHR, PAX8, NKX2-5
gland development (GO:0048732) 4.153PAX8, THRA, NKX2-5
negative regulation of cellular process (GO:0048523) 1.413PAX8, THRA, NKX2-5
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) 6.592NKX2-5, THRA
regulation of developmental growth (GO:0048638) 4.042TSHR, NKX2-5
response to extracellular stimulus (GO:0009991) 3.712TSHB, THRA
negative regulation of metabolic process (GO:0009892) 1.932NKX2-5, THRA
regulation of myotube differentiation (GO:0010830) 5.692THRA, NKX2-5
negative regulation of biosynthetic process (GO:0009890) 2.472THRA, NKX2-5
negative regulation of cellular biosynthetic process (GO:0031327) 2.492THRA, NKX2-5
negative regulation of cellular metabolic process (GO:0031324) 2.012THRA, NKX2-5
cell development (GO:0048468) 3.282TSHR, NKX2-5
behavior (GO:0007610) 3.472TSHR, THRA
kidney development (GO:0001822) 4.792PAX8, THRA
regulation of cell proliferation (GO:0042127) 2.412TSHR, NKX2-5
negative regulation of gene expression (GO:0010629) 2.482NKX2-5, THRA
signaling (GO:0023052) 3.252TSHB, TSHR
regulation of muscle cell differentiation (GO:0051147) 4.682NKX2-5, THRA
multicellular organism development (GO:0007275) 2.542PAX8, NKX2-5
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552THRA, NKX2-5
hormone-mediated signaling pathway (GO:0009755) 4.662TSHR, THRA
pattern specification process (GO:0007389) 3.792PAX8, NKX2-5
negative regulation of macromolecule metabolic process (GO:0010605) 2.012THRA, NKX2-5
regulation of system process (GO:0044057) 3.532NKX2-5, THRA
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122NKX2-5, THRA
regulation of signal transduction (GO:0009966) 1.842NKX2-5, THRA
regulation of growth (GO:0040008) 3.262TSHR, NKX2-5
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62NKX2-5, THRA
regulation of cell development (GO:0060284) 3.012PAX8, NKX2-5
negative regulation of apoptotic process (GO:0043066) 3.042PAX8, NKX2-5
positive regulation of cell development (GO:0010720) 3.572PAX8, NKX2-5
regulation of molecular function (GO:0065009) 1.782TSHR, THRA
negative regulation of programmed cell death (GO:0043069) 3.022PAX8, NKX2-5
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012PAX8, NKX2-5
positive regulation of cell proliferation (GO:0008284) 3.012TSHR, NKX2-5
organ morphogenesis (GO:0009887) 3.552NKX2-5, THRA
epithelium development (GO:0060429) 4.572PAX8, NKX2-5
tube morphogenesis (GO:0035239) 4.352PAX8, NKX2-5
tissue morphogenesis (GO:0048729) 3.872PAX8, NKX2-5
morphogenesis of an epithelium (GO:0002009) 4.082PAX8, NKX2-5
negative regulation of cell death (GO:0060548) 2.952PAX8, NKX2-5
regulation of heart contraction (GO:0008016) 4.352THRA, NKX2-5
tissue development (GO:0009888) 3.272PAX8, NKX2-5
regulation of response to stimulus (GO:0048583) 1.542THRA, NKX2-5
regulation of hormone levels (GO:0010817) 3.562TSHB, PAX8
negative regulation of RNA biosynthetic process (GO:1902679) 2.72THRA, NKX2-5
regulation of striated muscle cell differentiation (GO:0051153) 5.262NKX2-5, THRA
regulation of blood circulation (GO:1903522) 4.052NKX2-5, THRA
regionalization (GO:0003002) 4.242PAX8, NKX2-5
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472NKX2-5, THRA
cell-cell signaling (GO:0007267) 3.352TSHB, TSHR
cell communication (GO:0007154) 3.042TSHR, TSHB
regulation of protein complex assembly (GO:0043254) 3.832THRA, NKX2-5
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712NKX2-5, THRA
response to organic substance (GO:0010033) 2.22TSHB, PAX8
system process (GO:0003008) 2.32THRA, NKX2-5
negative regulation of developmental process (GO:0051093) 3.172PAX8, NKX2-5
single organism signaling (GO:0044700) 3.252TSHR, TSHB
response to external stimulus (GO:0009605) 2.552TSHB, THRA
thyroid-stimulating hormone signaling pathway (GO:0038194) 9.042TSHR, PAX8
single-organism behavior (GO:0044708) 3.792TSHR, THRA
negative regulation of RNA metabolic process (GO:0051253) 2.662THRA, NKX2-5
response to nutrient levels (GO:0031667) 3.772TSHB, THRA
regulation of cellular component biogenesis (GO:0044087) 3.082NKX2-5, THRA
regulation of DNA-templated transcription, initiation (GO:2000142) 6.292NKX2-5, THRA
regulation of multicellular organismal development (GO:2000026) 2.312PAX8, NKX2-5
negative regulation of transcription, DNA-templated (GO:0045892) 2.752NKX2-5, THRA
positive regulation of cellular component organization (GO:0051130) 2.682PAX8, NKX2-5
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532THRA, NKX2-5

NET-GE enrichment

Term New enriched termICP valueGenes
hormone-mediated signaling pathway (GO:0009755) -4.660.0TSHB, TSHR, THRA, NKX2-5
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) -6.590.038THRA, NKX2-5
epithelium development (GO:0060429) -4.570.032THRA, TSHR, PAX8, NKX2-5
thyroid-stimulating hormone signaling pathway (GO:0038194) -9.040.0TSHR, PAX8
response to lipid (GO:0033993) NEW3.110.027NKX2-5, TSHB, TSHR, THRA, PAX8
specification of organ identity (GO:0010092) NEW7.160.042PAX8, NKX2-5
pattern specification involved in kidney development (GO:0061004) NEW7.530.009PAX8, NKX2-5
cellular response to lipid (GO:0071396) NEW3.960.047TSHR, PAX8, THRA, NKX2-5
regulation of striated muscle cell differentiation (GO:0051153) -5.260.023TSHR, THRA, NKX2-5
cellular response to hormone stimulus (GO:0032870) NEW3.990.003THRA, TSHR, TSHB, NKX2-5, PAX8
regulation of DNA-templated transcription, initiation (GO:2000142) -6.290.004NKX2-5, THRA
regulation of myotube differentiation (GO:0010830) -5.690.046NKX2-5, THRA
response to hormone (GO:0009725) NEW3.330.042THRA, TSHR, TSHB, NKX2-5, PAX8
response to vitamin A (GO:0033189) NEW6.640.0TSHB, TSHR, THRA
gland development (GO:0048732) -4.150.009TSHR, PAX8, THRA, NKX2-5
peptide hormone processing (GO:0016486) NEW6.290.001TSHB, TSHR, NKX2-5
thyroid gland development (GO:0030878) -6.470.0TSHR, PAX8, THRA, NKX2-5
tube development (GO:0035295) -4.410.006TSHR, PAX8, THRA, NKX2-5
response to organic cyclic compound (GO:0014070) NEW3.070.038NKX2-5, TSHB, TSHR, THRA, PAX8
morphogenesis of an epithelium (GO:0002009) -4.080.043TSHR, PAX8, THRA, NKX2-5
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.114TSHR, PAX8, THRA, NKX2-5
intracellular membrane-bounded organelle (GO:0043231) 0.63PAX8, THRA, NKX2-5
nucleus (GO:0005634) 1.073PAX8, NKX2-5, THRA
intracellular organelle part (GO:0044446) 0.813PAX8, NKX2-5, THRA
intracellular organelle (GO:0043229) 0.513PAX8, NKX2-5, THRA
nuclear part (GO:0044428) 1.553PAX8, THRA, NKX2-5
intracellular part (GO:0044424) 0.283PAX8, THRA, NKX2-5
membrane-bounded organelle (GO:0043227) 0.473PAX8, NKX2-5, THRA
organelle (GO:0043226) 0.43PAX8, NKX2-5, THRA
organelle part (GO:0044422) 0.793PAX8, THRA, NKX2-5
cytoplasm (GO:0005737) 1.012NKX2-5, THRA
nucleoplasm (GO:0005654) 1.892PAX8, THRA
protein complex (GO:0043234) 1.512TSHR, NKX2-5
macromolecular complex (GO:0032991) 1.352TSHR, NKX2-5