Disease ID | Disease name | Source of annotation with TSHB | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS275200 | HYPOTHYROIDISM, CONGENITAL, NONGOITROUS | ClinVar, OMIM | link to OMIM | 5 | PAX8, THRA, NKX2-5, TSHB, TSHR |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Thyroid hormone synthesis | hsa04918 | 6.56 |
Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
Autoimmune thyroid disease | hsa05320 | 6.62 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Hormone ligand-binding receptors | R-HSA-375281 | 9.52 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
Metabolism of amino acids and derivatives | R-HSA-71291 | 5.4 |
Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
Peptide hormone biosynthesis | R-HSA-209952 | 9.4 |
Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
Amine-derived hormones | R-HSA-209776 | 8.98 |
Metabolism | R-HSA-1430728 | 2.34 |
Metabolism of proteins | R-HSA-392499 | 3.41 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Thyroxine biosynthesis | R-HSA-209968 | 9.98 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
G alpha (s) signalling events | R-HSA-418555 | 5.99 |
Signal Transduction | R-HSA-162582 | 1.78 |
Glycoprotein hormones | R-HSA-209822 | 9.66 |
GO term | GO ID | GO IC |
---|---|---|
hormone activity | GO:0005179 | 4.95 |
receptor binding | GO:0005102 | 2.43 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |