Disease table of CIRRHOSIS, FAMILIAL OMIM ID: 215600

Gene-disease associations table

GeneAssociated with CIRRHOSIS, FAMILIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
KRT8OMIM, HUMSAVARHGNC link12q13.132215600, 609532
KRT18OMIM, HUMSAVARHGNC link12q13.132215600, 609532

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
12q13.132KRT8, KRT18
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
12q132KRT8, KRT18
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12q12KRT8, KRT18
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
12q2KRT8, KRT18
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122KRT8, KRT18
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KRT18YES3SP1, BRCA1, CTBP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
KRT8KRT18Yes21NOS2, USP32, CDH1, PNN, IKBKG, KRT18, FN1, RCHY1, KPNA2, EED, KRT15, IQCB1, PRKCE, ESR1, VCAM1, ATF2, FAF2, ITGA4, YWHAQ, GRB2, PAN2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
KRT8KRT18Yesbinding4UBC, USP10, TCHP, DSP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
KRT18KRT8yes, complexKRT18 associates with KRT8. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
scaffold protein binding (GO:0097110) 5.932KRT18, KRT8
binding (GO:0005488) 0.182KRT18, KRT8
protein binding (GO:0005515) 0.462KRT18, KRT8
structural molecule activity (GO:0005198) 3.12KRT18, KRT8

NET-GE enrichment

Term New enriched termICP valueGenes
scaffold protein binding (GO:0097110) -5.930.0KRT18, KRT8
structural molecule activity (GO:0005198) -3.10.017KRT18, KRT8
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytokine-mediated signaling pathway (GO:0019221) 3.62KRT18, KRT8
tumor necrosis factor-mediated signaling pathway (GO:0033209) 4.962KRT18, KRT8
apoptotic signaling pathway (GO:0097190) 4.122KRT18, KRT8
extrinsic apoptotic signaling pathway (GO:0097191) 5.162KRT18, KRT8
signal transduction (GO:0007165) 1.282KRT18, KRT8
cell surface receptor signaling pathway (GO:0007166) 2.092KRT18, KRT8
cell death (GO:0008219) 3.052KRT18, KRT8
regulation of biological process (GO:0050789) 0.452KRT18, KRT8
single-organism process (GO:0044699) 0.482KRT18, KRT8
epithelial cell apoptotic process (GO:1904019) 6.512KRT18, KRT8
cellular component organization (GO:0016043) 1.242KRT18, KRT8
interspecies interaction between organisms (GO:0044419) 3.082KRT18, KRT8
biological regulation (GO:0065007) 0.392KRT18, KRT8
cellular component organization or biogenesis (GO:0071840) 1.222KRT18, KRT8
hepatocyte apoptotic process (GO:0097284) 7.162KRT18, KRT8
developmental process (GO:0032502) 1.362KRT18, KRT8
cellular process (GO:0009987) 0.262KRT18, KRT8
apoptotic process (GO:0006915) 3.142KRT18, KRT8
regulation of cellular process (GO:0050794) 0.52KRT18, KRT8
programmed cell death (GO:0012501) 3.12KRT18, KRT8
multi-organism cellular process (GO:0044764) 3.142KRT18, KRT8
single-organism cellular process (GO:0044763) 0.652KRT18, KRT8
multi-organism process (GO:0051704) 2.652KRT18, KRT8
organelle organization (GO:0006996) 2.022KRT18, KRT8
cytoskeleton organization (GO:0007010) 3.222KRT18, KRT8
single-organism organelle organization (GO:1902589) 2.682KRT18, KRT8
viral process (GO:0016032) 3.152KRT18, KRT8
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152KRT18, KRT8

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine-mediated signaling pathway (GO:0019221) -3.60.047KRT18, KRT8
intermediate filament cytoskeleton organization (GO:0045104) NEW6.040.003KRT18, KRT8
response to tumor necrosis factor (GO:0034612) NEW4.930.003KRT18, KRT8
tumor necrosis factor-mediated signaling pathway (GO:0033209) -4.960.0KRT18, KRT8
apoptotic signaling pathway (GO:0097190) -4.120.029KRT18, KRT8
extrinsic apoptotic signaling pathway (GO:0097191) -5.160.002KRT18, KRT8
intermediate filament-based process (GO:0045103) NEW6.020.003KRT18, KRT8
cellular response to tumor necrosis factor (GO:0071356) NEW5.190.002KRT18, KRT8
hepatocyte apoptotic process (GO:0097284) -7.160.0KRT18, KRT8
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
supramolecular fiber (GO:0099512) 3.312KRT18, KRT8
polymeric cytoskeletal fiber (GO:0099513) 3.312KRT18, KRT8
keratin filament (GO:0045095) 5.212KRT18, KRT8
intracellular organelle (GO:0043229) 0.512KRT18, KRT8
cell periphery (GO:0071944) 5.782KRT18, KRT8
membrane-bounded organelle (GO:0043227) 0.472KRT18, KRT8
organelle (GO:0043226) 0.42KRT18, KRT8
cytoplasm (GO:0005737) 1.012KRT18, KRT8
vesicle (GO:0031982) 1.642KRT18, KRT8
nucleus (GO:0005634) 1.072KRT18, KRT8
membrane-bounded vesicle (GO:0031988) 1.712KRT18, KRT8
cytoskeletal part (GO:0044430) 2.492KRT18, KRT8
intermediate filament (GO:0005882) 4.482KRT18, KRT8
extracellular vesicle (GO:1903561) 1.892KRT18, KRT8
extracellular exosome (GO:0070062) 1.892KRT18, KRT8
extracellular organelle (GO:0043230) 1.892KRT18, KRT8
intracellular membrane-bounded organelle (GO:0043231) 0.62KRT18, KRT8
cell part (GO:0044464) 0.112KRT18, KRT8
intracellular organelle part (GO:0044446) 0.812KRT18, KRT8
cytoplasmic part (GO:0044444) 0.822KRT18, KRT8
nuclear part (GO:0044428) 1.552KRT18, KRT8
intracellular part (GO:0044424) 0.282KRT18, KRT8
extracellular region part (GO:0044421) 1.572KRT18, KRT8
organelle part (GO:0044422) 0.792KRT18, KRT8

NET-GE enrichment

Term New enriched termICP valueGenes
keratin filament (GO:0045095) -5.210.001KRT18, KRT8
intermediate filament (GO:0005882) -4.480.005KRT18, KRT8