Disease table of HEPATITIS C VIRUS, SUSCEPTIBILITY TO OMIM ID: 609532

Gene-disease associations table

GeneAssociated with HEPATITIS C VIRUS, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IFNL3OMIMHGNC link19q13.21609532
IFNGOMIMHGNC link12q155609135, PS191100, 609532, 607948, 609423
PTPRCClinVar, OMIMHGNC link1q31.32608971, 609532
CCR5OMIMHGNC link3p21.314612522, 609423, 610379, 609532
KRT8ClinVarHGNC link12q13.132215600, 609532
KRT18ClinVarHGNC link12q13.132215600, 609532

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
12q13.132KRT8, KRT18
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
12q132KRT8, KRT18
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12q13IFNG, KRT8, KRT18
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
12q3IFNG, KRT8, KRT18
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
123IFNG, KRT8, KRT18
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
YY1NO74FCER1A, CFTR, EGFR, GDAP1, POSTN, TP53, ATP2C1, IFNG, ADORA2A, KIR3DL1, TOP3A, HBE1, LDLR, SERPINE1, LRIG2, HSPA5, GBP1, HLA-DRA, APC, HAS2, CCL13, SNRPN, FMO3, TFRC, CTCF, FAS, TF, CXCR4, FCGR3B, DNAJB4, HSD3B2, ERBB2, SURF1, TDO2, IVL, BRCA1, DEK, COX7C, CETP, ERCC5, NOS2, BDKRB1, SLC26A3, EPAS1, ACTC1, ZNF175, BAP1, TNFRSF10B, HOXB7, NF1, OPRM1, PCNA, PARP1, PRDM2, VWF, TP73, CCR5, CBX5, SURF2, IL4, NR3C1, PDIA6, CYP3A5, CREBBP, HCFC1, IL5, DBH, RB1, FDPS, FCGR2B, LSS, MYC, HOXB13, COL1A22CCR5, IFNG
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62CCR5, IFNG
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62CCR5, IFNG
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IFNL3YES1IRF70
IFNGYES29BCL6, TFAP4, NFATC2, TBX21, EGR1, NFKB1, CREB1, STAT5A, NFATC1, JUN, GATA1, ATF2, RELA, PARP1, GATA3, EP300, STAT1, STAT3, PROX1, RFX5, EOMES, YY1, NFIL3, STAT5B, MSC, MYCN, STAT4, IRF1, USF10
PTPRCYES1ESR20
CCR5YES5NR3C2, YY1, NFKB1, KLF2, RELA0
KRT18YES3SP1, BRCA1, CTBP10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTPRCCCR5No1CD4
KRT8KRT18Yes21NOS2, USP32, CDH1, PNN, IKBKG, KRT18, FN1, RCHY1, KPNA2, EED, KRT15, IQCB1, PRKCE, ESR1, VCAM1, ATF2, FAF2, ITGA4, YWHAQ, GRB2, PAN2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IFNGPTPRCNo-1IL2
IFNGCCR5No-12IL12RB2, STAT3, CXCL11, IL18R1, IL18RAP, IL18, TYK2, JUN, JAK2, IL12RB1, IL12A, ETV5
PTPRCCCR5No-0
CCR5KRT8No-1IL4
KRT8KRT18Yesbinding4UBC, USP10, TCHP, DSP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
KRT18KRT8yes, complexKRT18 associates with KRT8. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Cytokine-cytokine receptor interactionhsa040604.673IFNL3, CCR5, IFNG
T cell receptor signaling pathwayhsa046606.012PTPRC, IFNG
Toxoplasmosishsa051455.712CCR5, IFNG
Jak-STAT signaling pathwayhsa046305.442IFNL3, IFNG

NET-GE enrichment

Term New enriched termICP valueGenes
Intestinal immune network for IgA production (hsa04672) NEW6.790.004CCR5, PTPRC, IFNG
Signaling molecules and interactionNEW3.090.045CCR5, IFNL3, PTPRC, IFNG
Infectious diseases: BacterialNEW3.760.036KRT18, PTPRC, CCR5, KRT8, IFNG
Cytokine-cytokine receptor interaction (hsa04060) -4.670.03IFNL3, CCR5, IFNG
Salmonella infection (hsa05132) NEW6.290.023CCR5, KRT8, IFNG
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.372PTPRC, IFNG

NET-GE enrichment

Term New enriched termICP valueGenes
Cross-presentation of soluble exogenous antigens (endosomes) (R-HSA-1236978) NEW7.370.037CCR5, IFNG
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
protein binding (GO:0005515) 0.466KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
hydrolase activity (GO:0016787) 1.92CCR5, PTPRC
cytokine activity (GO:0005125) 4.342IFNL3, IFNG
signaling receptor activity (GO:0038023) 2.492CCR5, PTPRC
catalytic activity (GO:0003824) 1.052CCR5, PTPRC
hydrolase activity, acting on ester bonds (GO:0016788) 3.12CCR5, PTPRC
structural molecule activity (GO:0005198) 3.12KRT18, KRT8
phosphoric ester hydrolase activity (GO:0042578) 3.822CCR5, PTPRC
molecular transducer activity (GO:0060089) 2.322CCR5, PTPRC
transmembrane signaling receptor activity (GO:0004888) 2.572CCR5, PTPRC
scaffold protein binding (GO:0097110) 5.932KRT18, KRT8
receptor activity (GO:0004872) 2.322CCR5, PTPRC
signal transducer activity (GO:0004871) 2.282CCR5, PTPRC
receptor binding (GO:0005102) 2.432IFNL3, IFNG
transmembrane receptor activity (GO:0099600) 2.532CCR5, PTPRC

NET-GE enrichment

Term New enriched termICP valueGenes
chemokine binding (GO:0019956) NEW6.690.004CCR5, IFNG
proteoglycan binding (GO:0043394) NEW6.340.045PTPRC, IFNG
scaffold protein binding (GO:0097110) -5.930.003KRT18, KRT8
receptor binding (GO:0005102) -2.430.013KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.266KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
regulation of cellular process (GO:0050794) 0.56KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
interspecies interaction between organisms (GO:0044419) 3.086KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
multi-organism cellular process (GO:0044764) 3.146KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
biological regulation (GO:0065007) 0.396KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
signal transduction (GO:0007165) 1.286KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
viral process (GO:0016032) 3.156KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.156KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
regulation of biological process (GO:0050789) 0.456KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
multi-organism process (GO:0051704) 2.656KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
response to biotic stimulus (GO:0009607) 3.095IFNL3, PTPRC, CCR5, KRT8, IFNG
response to external stimulus (GO:0009605) 2.555CCR5, PTPRC, IFNL3, KRT8, IFNG
response to external biotic stimulus (GO:0043207) 3.135CCR5, IFNL3, PTPRC, IFNG, KRT8
response to stimulus (GO:0050896) 1.225CCR5, PTPRC, IFNL3, KRT8, IFNG
response to stress (GO:0006950) 1.85CCR5, PTPRC, IFNL3, KRT8, IFNG
single-organism cellular process (GO:0044763) 0.655KRT18, PTPRC, CCR5, KRT8, IFNG
single-organism process (GO:0044699) 0.485KRT18, PTPRC, CCR5, KRT8, IFNG
cell surface receptor signaling pathway (GO:0007166) 2.095KRT18, PTPRC, CCR5, KRT8, IFNG
negative regulation of biological process (GO:0048519) 1.335KRT18, CCR5, IFNL3, PTPRC, IFNG
negative regulation of cellular process (GO:0048523) 1.415KRT18, CCR5, IFNL3, PTPRC, IFNG
defense response (GO:0006952) 2.784CCR5, IFNL3, PTPRC, IFNG
regulation of localization (GO:0032879) 1.944CCR5, IFNL3, PTPRC, IFNG
cytokine-mediated signaling pathway (GO:0019221) 3.64KRT18, CCR5, KRT8, IFNG
transport (GO:0006810) 1.514KRT18, CCR5, PTPRC, IFNG
immune system process (GO:0002376) 2.294CCR5, IFNL3, PTPRC, IFNG
establishment of localization (GO:0051234) 1.484KRT18, CCR5, PTPRC, IFNG
response to other organism (GO:0051707) 3.484PTPRC, IFNL3, IFNG, KRT8
localization (GO:0051179) 1.44KRT18, CCR5, PTPRC, IFNG
regulation of cell activation (GO:0050865) 3.533IFNL3, PTPRC, IFNG
regulation of cell adhesion (GO:0030155) 3.273IFNL3, PTPRC, IFNG
positive regulation of response to stimulus (GO:0048584) 2.183IFNL3, PTPRC, IFNG
regulation of response to stimulus (GO:0048583) 1.543IFNL3, PTPRC, IFNG
extrinsic apoptotic signaling pathway (GO:0097191) 5.163KRT18, KRT8, IFNG
regulation of T cell activation (GO:0050863) 4.053IFNL3, PTPRC, IFNG
regulation of cell-cell adhesion (GO:0022407) 3.793IFNL3, PTPRC, IFNG
cell death (GO:0008219) 3.053KRT18, KRT8, IFNG
cellular component organization or biogenesis (GO:0071840) 1.223KRT18, CCR5, KRT8
regulation of lymphocyte activation (GO:0051249) 3.733IFNL3, PTPRC, IFNG
establishment of localization in cell (GO:0051649) 2.473CCR5, PTPRC, IFNG
cellular developmental process (GO:0048869) 1.823PTPRC, KRT8, IFNG
cellular component organization (GO:0016043) 1.243KRT18, CCR5, KRT8
positive regulation of immune system process (GO:0002684) 2.963IFNL3, PTPRC, IFNG
regulation of immune system process (GO:0002682) 2.53IFNL3, PTPRC, IFNG
immune effector process (GO:0002252) 3.583IFNL3, PTPRC, IFNG
positive regulation of biological process (GO:0048518) 1.23IFNL3, PTPRC, IFNG
regulation of biological quality (GO:0065008) 1.683CCR5, PTPRC, IFNG
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013IFNL3, PTPRC, IFNG
developmental process (GO:0032502) 1.363KRT18, PTPRC, KRT8
cell differentiation (GO:0030154) 2.143PTPRC, KRT8, IFNG
apoptotic signaling pathway (GO:0097190) 4.123KRT18, KRT8, IFNG
apoptotic process (GO:0006915) 3.143KRT18, KRT8, IFNG
programmed cell death (GO:0012501) 3.13KRT18, KRT8, IFNG
single-organism transport (GO:0044765) 2.183KRT18, CCR5, PTPRC
defense response to other organism (GO:0098542) 3.753IFNL3, PTPRC, IFNG
immune response (GO:0006955) 2.863IFNL3, CCR5, IFNG
response to chemical (GO:0042221) 1.983CCR5, KRT8, IFNG
single-organism localization (GO:1902578) 2.093KRT18, CCR5, PTPRC
response to oxygen-containing compound (GO:1901700) 2.573CCR5, KRT8, IFNG
regulation of immune response (GO:0050776) 2.983IFNL3, PTPRC, IFNG
defense response to virus (GO:0051607) 4.633IFNL3, PTPRC, IFNG
positive regulation of immune response (GO:0050778) 3.43IFNL3, PTPRC, IFNG
regulation of leukocyte activation (GO:0002694) 3.63IFNL3, PTPRC, IFNG
response to virus (GO:0009615) 4.213IFNL3, PTPRC, IFNG
positive regulation of cellular process (GO:0048522) 1.33IFNL3, PTPRC, IFNG
protein localization (GO:0008104) 2.362KRT18, IFNG
regulation of phosphate metabolic process (GO:0019220) 2.352PTPRC, IFNG
regulation of primary metabolic process (GO:0080090) 1.082PTPRC, IFNG
regulation of metabolic process (GO:0019222) 1.022PTPRC, IFNG
regulation of transport (GO:0051049) 2.242IFNL3, IFNG
regulation of sequestering of calcium ion (GO:0051282) 5.072CCR5, PTPRC
negative regulation of sequestering of calcium ion (GO:0051283) 6.042CCR5, PTPRC
negative regulation of homeostatic process (GO:0032845) 4.912CCR5, PTPRC
regulation of homeostatic process (GO:0032844) 3.652CCR5, PTPRC
regulation of lymphocyte mediated immunity (GO:0002706) 4.992PTPRC, IFNG
regulation of leukocyte mediated immunity (GO:0002703) 4.72PTPRC, IFNG
calcium ion homeostasis (GO:0055074) 3.972CCR5, PTPRC
cell chemotaxis (GO:0060326) 4.632CCR5, IFNG
inorganic ion homeostasis (GO:0098771) 3.432CCR5, PTPRC
cellular response to stimulus (GO:0051716) 1.972CCR5, IFNG
negative regulation of macromolecule metabolic process (GO:0010605) 2.012PTPRC, IFNG
positive regulation of macromolecule metabolic process (GO:0010604) 1.812PTPRC, IFNG
taxis (GO:0042330) 4.032CCR5, IFNG
positive regulation of cell adhesion (GO:0045785) 3.792PTPRC, IFNG
regulation of signal transduction (GO:0009966) 1.842PTPRC, IFNG
positive regulation of signal transduction (GO:0009967) 2.52PTPRC, IFNG
cellular response to organic substance (GO:0071310) 2.782CCR5, IFNG
release of sequestered calcium ion into cytosol (GO:0051209) 6.042CCR5, PTPRC
positive regulation of molecular function (GO:0044093) 2.232PTPRC, IFNG
macromolecule localization (GO:0033036) 2.342KRT18, IFNG
regulation of cell proliferation (GO:0042127) 2.412PTPRC, IFNG
leukocyte chemotaxis (GO:0030595) 4.962CCR5, IFNG
chemotaxis (GO:0006935) 4.042CCR5, IFNG
T cell differentiation (GO:0030217) 5.112PTPRC, IFNG
regulation of macromolecule metabolic process (GO:0060255) 1.082PTPRC, IFNG
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 4.992PTPRC, IFNG
regulation of T cell proliferation (GO:0042129) 4.742PTPRC, IFNG
establishment of protein localization (GO:0045184) 2.532KRT18, IFNG
lymphocyte activation (GO:0046649) 3.962PTPRC, IFNG
calcium ion import into cytosol (GO:1902656) 5.992CCR5, PTPRC
divalent inorganic cation transport (GO:0072511) 4.132CCR5, PTPRC
response to abiotic stimulus (GO:0009628) 2.82PTPRC, KRT8
response to organic substance (GO:0010033) 2.22CCR5, IFNG
regulation of phosphorylation (GO:0042325) 2.52PTPRC, IFNG
positive regulation of signaling (GO:0023056) 2.412PTPRC, IFNG
positive regulation of phosphorylation (GO:0042327) 2.92PTPRC, IFNG
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062PTPRC, IFNG
membrane organization (GO:0061024) 3.042KRT18, CCR5
protein metabolic process (GO:0019538) 1.452CCR5, PTPRC
cell motility (GO:0048870) 3.022CCR5, IFNG
calcium ion transmembrane transport (GO:0070588) 4.672CCR5, PTPRC
positive regulation of cytosolic calcium ion concentration (GO:0007204) 4.562CCR5, PTPRC
chemical homeostasis (GO:0048878) 2.972CCR5, PTPRC
calcium ion import (GO:0070509) 5.572CCR5, PTPRC
negative regulation of metabolic process (GO:0009892) 1.932PTPRC, IFNG
positive regulation of metabolic process (GO:0009893) 1.742PTPRC, IFNG
regulation of multi-organism process (GO:0043900) 3.62IFNL3, IFNG
positive regulation of cell migration (GO:0030335) 3.772PTPRC, IFNG
movement of cell or subcellular component (GO:0006928) 2.612CCR5, IFNG
regulation of cell killing (GO:0031341) 5.62PTPRC, IFNG
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842PTPRC, IFNG
regulation of mononuclear cell proliferation (GO:0032944) 4.452PTPRC, IFNG
intracellular signal transduction (GO:0035556) 2.392IFNL3, CCR5
regulation of protein transport (GO:0051223) 3.122IFNL3, IFNG
regulation of apoptotic process (GO:0042981) 2.52KRT18, IFNG
cellular protein metabolic process (GO:0044267) 1.632CCR5, PTPRC
regulation of cell communication (GO:0010646) 1.732PTPRC, IFNG
immune response-regulating signaling pathway (GO:0002764) 3.722PTPRC, IFNG
cellular macromolecule metabolic process (GO:0044260) 0.932CCR5, PTPRC
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962PTPRC, IFNG
cation transmembrane transport (GO:0098655) 3.432CCR5, PTPRC
inorganic cation transmembrane transport (GO:0098662) 3.552CCR5, PTPRC
cellular response to molecule of bacterial origin (GO:0071219) 4.882CCR5, IFNG
inorganic ion transmembrane transport (GO:0098660) 3.382CCR5, PTPRC
cellular response to biotic stimulus (GO:0071216) 4.762CCR5, IFNG
regulation of molecular function (GO:0065009) 1.782PTPRC, IFNG
lymphocyte aggregation (GO:0071593) 4.442PTPRC, IFNG
calcium ion transmembrane import into cytosol (GO:0097553) 5.992CCR5, PTPRC
positive regulation of cellular component organization (GO:0051130) 2.682IFNL3, IFNG
regulation of establishment of protein localization (GO:0070201) 3.022IFNL3, IFNG
single organism cell adhesion (GO:0098602) 3.632PTPRC, IFNG
cell-cell adhesion (GO:0098609) 3.342PTPRC, IFNG
cation transport (GO:0006812) 3.112CCR5, PTPRC
ion transport (GO:0006811) 2.662CCR5, PTPRC
regulation of catalytic activity (GO:0050790) 1.972PTPRC, IFNG
calcium ion transport (GO:0006816) 4.332CCR5, PTPRC
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822IFNL3, IFNG
cell activation (GO:0001775) 3.472PTPRC, IFNG
negative regulation of multi-organism process (GO:0043901) 4.72IFNL3, IFNG
metabolic process (GO:0008152) 0.582CCR5, PTPRC
primary metabolic process (GO:0044238) 0.692CCR5, PTPRC
leukocyte differentiation (GO:0002521) 4.132PTPRC, IFNG
single-organism developmental process (GO:0044767) 1.492PTPRC, KRT8
immune response-activating signal transduction (GO:0002757) 3.82PTPRC, IFNG
positive regulation of protein modification process (GO:0031401) 2.72PTPRC, IFNG
macromolecule modification (GO:0043412) 1.732CCR5, PTPRC
regulation of immune effector process (GO:0002697) 3.712PTPRC, IFNG
positive regulation of leukocyte activation (GO:0002696) 4.02PTPRC, IFNG
regulation of cell motility (GO:2000145) 3.162PTPRC, IFNG
positive regulation of cell motility (GO:2000147) 3.742PTPRC, IFNG
leukocyte cell-cell adhesion (GO:0007159) 4.262PTPRC, IFNG
positive regulation of catalytic activity (GO:0043085) 2.42PTPRC, IFNG
ion homeostasis (GO:0050801) 3.422CCR5, PTPRC
tumor necrosis factor-mediated signaling pathway (GO:0033209) 4.962KRT18, KRT8
regulation of adaptive immune response (GO:0002819) 4.912PTPRC, IFNG
regulation of cellular component organization (GO:0051128) 2.012IFNL3, IFNG
regulation of cellular protein localization (GO:1903827) 3.432IFNL3, IFNG
regulation of response to cytokine stimulus (GO:0060759) 4.772PTPRC, IFNG
cellular response to chemical stimulus (GO:0070887) 2.572CCR5, IFNG
regulation of signaling (GO:0023051) 1.722PTPRC, IFNG
cellular response to lipopolysaccharide (GO:0071222) 4.942CCR5, IFNG
positive regulation of cell communication (GO:0010647) 2.412PTPRC, IFNG
positive regulation of establishment of protein localization (GO:1904951) 3.492IFNL3, IFNG
positive regulation of cellular protein localization (GO:1903829) 3.852IFNL3, IFNG
regulation of protein localization (GO:0032880) 2.882IFNL3, IFNG
divalent inorganic cation homeostasis (GO:0072507) 3.92CCR5, PTPRC
epithelial cell apoptotic process (GO:1904019) 6.512KRT18, KRT8
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962CCR5, PTPRC
positive regulation of phosphorus metabolic process (GO:0010562) 2.782PTPRC, IFNG
regulation of protein metabolic process (GO:0051246) 1.932PTPRC, IFNG
positive regulation of protein metabolic process (GO:0051247) 2.432PTPRC, IFNG
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.352PTPRC, IFNG
positive regulation of cellular protein metabolic process (GO:0032270) 2.492PTPRC, IFNG
protein modification process (GO:0036211) 1.792CCR5, PTPRC
regulation of protein modification process (GO:0031399) 2.322PTPRC, IFNG
biological adhesion (GO:0022610) 2.812PTPRC, IFNG
positive regulation of cellular metabolic process (GO:0031325) 1.812PTPRC, IFNG
positive regulation of cell proliferation (GO:0008284) 3.012PTPRC, IFNG
organelle organization (GO:0006996) 2.022KRT18, KRT8
cellular response to oxygen-containing compound (GO:1901701) 3.222CCR5, IFNG
cellular metal ion homeostasis (GO:0006875) 3.752CCR5, PTPRC
cellular calcium ion homeostasis (GO:0006874) 4.012CCR5, PTPRC
cellular response to lipid (GO:0071396) 3.962CCR5, IFNG
cellular ion homeostasis (GO:0006873) 3.572CCR5, PTPRC
positive regulation of B cell activation (GO:0050871) 5.272PTPRC, IFNG
regulation of cellular component movement (GO:0051270) 3.082PTPRC, IFNG
metal ion transport (GO:0030001) 3.362CCR5, PTPRC
cellular cation homeostasis (GO:0030003) 3.62CCR5, PTPRC
cation homeostasis (GO:0055080) 3.462CCR5, PTPRC
cellular chemical homeostasis (GO:0055082) 3.42CCR5, PTPRC
regulation of protein phosphorylation (GO:0001932) 2.572PTPRC, IFNG
transmembrane transport (GO:0055085) 2.722CCR5, PTPRC
regulation of cellular protein metabolic process (GO:0032268) 1.992PTPRC, IFNG
divalent metal ion transport (GO:0070838) 4.152CCR5, PTPRC
regulation of cytokine-mediated signaling pathway (GO:0001959) 4.822PTPRC, IFNG
leukocyte activation (GO:0045321) 3.762PTPRC, IFNG
positive regulation of lymphocyte activation (GO:0051251) 4.072PTPRC, IFNG
regulation of lymphocyte proliferation (GO:0050670) 4.462PTPRC, IFNG
positive regulation of lymphocyte proliferation (GO:0050671) 4.852PTPRC, IFNG
macromolecule metabolic process (GO:0043170) 0.832CCR5, PTPRC
response to molecule of bacterial origin (GO:0002237) 3.992CCR5, IFNG
lymphocyte differentiation (GO:0030098) 4.492PTPRC, IFNG
cellular homeostasis (GO:0019725) 3.232CCR5, PTPRC
single organismal cell-cell adhesion (GO:0016337) 3.692PTPRC, IFNG
regulation of cellular localization (GO:0060341) 3.032IFNL3, IFNG
regulation of B cell activation (GO:0050864) 4.922PTPRC, IFNG
positive regulation of cell activation (GO:0050867) 3.972PTPRC, IFNG
negative regulation of cellular metabolic process (GO:0031324) 2.012PTPRC, IFNG
regulation of cellular metabolic process (GO:0031323) 1.072PTPRC, IFNG
T cell activation (GO:0042110) 4.452PTPRC, IFNG
homeostatic process (GO:0042592) 2.612CCR5, PTPRC
leukocyte migration (GO:0050900) 4.192CCR5, IFNG
cell cycle process (GO:0022402) 2.752PTPRC, IFNG
cell migration (GO:0016477) 3.122CCR5, IFNG
regulation of cell death (GO:0010941) 2.432KRT18, IFNG
positive regulation of protein transport (GO:0051222) 3.612IFNL3, IFNG
positive regulation of cell-cell adhesion (GO:0022409) 4.232PTPRC, IFNG
response to lipid (GO:0033993) 3.112CCR5, IFNG
positive regulation of transport (GO:0051050) 2.92IFNL3, IFNG
single-organism organelle organization (GO:1902589) 2.682KRT18, KRT8
organic substance metabolic process (GO:0071704) 0.632CCR5, PTPRC
regulation of programmed cell death (GO:0043067) 2.492KRT18, IFNG
positive regulation of leukocyte proliferation (GO:0070665) 4.792PTPRC, IFNG
organic substance transport (GO:0071702) 2.152KRT18, IFNG
hepatocyte apoptotic process (GO:0097284) 7.162KRT18, KRT8
antigen receptor-mediated signaling pathway (GO:0050851) 4.432PTPRC, IFNG
T cell receptor signaling pathway (GO:0050852) 4.712PTPRC, IFNG
regulation of cell migration (GO:0030334) 3.232PTPRC, IFNG
cytosolic calcium ion transport (GO:0060401) 5.742CCR5, PTPRC
positive regulation of phosphate metabolic process (GO:0045937) 2.782PTPRC, IFNG
cellular protein modification process (GO:0006464) 1.792CCR5, PTPRC
positive regulation of T cell proliferation (GO:0042102) 5.162PTPRC, IFNG
regulation of phosphorus metabolic process (GO:0051174) 2.352PTPRC, IFNG
ion transmembrane transport (GO:0034220) 3.082CCR5, PTPRC
T cell aggregation (GO:0070489) 4.452PTPRC, IFNG
positive regulation of T cell activation (GO:0050870) 4.392PTPRC, IFNG
metal ion homeostasis (GO:0055065) 3.612CCR5, PTPRC
cell adhesion (GO:0007155) 2.822PTPRC, IFNG
leukocyte aggregation (GO:0070486) 4.412PTPRC, IFNG
cellular localization (GO:0051641) 2.322KRT18, IFNG
locomotion (GO:0040011) 2.912CCR5, IFNG
positive regulation of cellular component movement (GO:0051272) 3.712PTPRC, IFNG
regulation of locomotion (GO:0040012) 3.122PTPRC, IFNG
cytoskeleton organization (GO:0007010) 3.222KRT18, KRT8
positive regulation of locomotion (GO:0040017) 3.712PTPRC, IFNG
regulation of cell cycle (GO:0051726) 2.932PTPRC, IFNG
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412CCR5, PTPRC
cellular metabolic process (GO:0044237) 0.692CCR5, PTPRC
regulation of leukocyte proliferation (GO:0070663) 4.42PTPRC, IFNG
phosphate-containing compound metabolic process (GO:0006796) 2.162CCR5, PTPRC
regulation of ion homeostasis (GO:2000021) 4.442CCR5, PTPRC
activation of immune response (GO:0002253) 3.672PTPRC, IFNG
phosphorus metabolic process (GO:0006793) 2.152CCR5, PTPRC
protein transport (GO:0015031) 2.622KRT18, IFNG
calcium ion transport into cytosol (GO:0060402) 5.782CCR5, PTPRC
response to lipopolysaccharide (GO:0032496) 4.032CCR5, IFNG
positive regulation of protein phosphorylation (GO:0001934) 2.952PTPRC, IFNG

NET-GE enrichment

Term New enriched termICP valueGenes
inflammatory cell apoptotic process (GO:0006925) NEW7.780.014CCR5, IFNG
regulation of isotype switching to IgG isotypes (GO:0048302) NEW7.530.014PTPRC, IFNG
positive regulation of isotype switching to IgG isotypes (GO:0048304) NEW7.940.004PTPRC, IFNG
positive regulation of kinase activity (GO:0033674) NEW3.540.041KRT18, PTPRC, CCR5, KRT8, IFNG
regulation of isotype switching (GO:0045191) NEW6.550.014PTPRC, IFNG
tumor necrosis factor-mediated signaling pathway (GO:0033209) -4.960.001KRT18, KRT8, IFNG
regulation of sequestering of calcium ion (GO:0051282) -5.070.03CCR5, PTPRC
extrinsic apoptotic signaling pathway (GO:0097191) -5.160.002KRT18, KRT8, IFNG
positive regulation of MAP kinase activity (GO:0043406) NEW4.390.025PTPRC, CCR5, KRT8, IFNG
regulation of MAP kinase activity (GO:0043405) NEW3.950.002KRT18, PTPRC, CCR5, KRT8, IFNG
positive regulation of muscle cell apoptotic process (GO:0010661) NEW7.090.045CCR5, IFNG
positive regulation of protein serine/threonine kinase activity (GO:0071902) NEW4.060.002KRT18, PTPRC, CCR5, KRT8, IFNG
regulation of protein serine/threonine kinase activity (GO:0071900) NEW3.580.019KRT18, PTPRC, CCR5, KRT8, IFNG
cytokine-mediated signaling pathway (GO:0019221) -3.60.003KRT18, CCR5, KRT8, IFNG
response to external biotic stimulus (GO:0043207) -3.130.0CCR5, IFNL3, PTPRC, IFNG, KRT8
positive regulation of cell adhesion (GO:0045785) -3.790.02PTPRC, CCR5, KRT8, IFNG
cellular response to tumor necrosis factor (GO:0071356) NEW5.190.001KRT18, CCR5, KRT8, IFNG
response to virus (GO:0009615) -4.210.049CCR5, IFNL3, PTPRC, IFNG
positive regulation of smooth muscle cell apoptotic process (GO:0034393) NEW7.650.011CCR5, IFNG
release of sequestered calcium ion into cytosol (GO:0051209) -6.040.027CCR5, PTPRC
positive regulation of isotype switching (GO:0045830) NEW6.960.006PTPRC, IFNG
positive regulation of DNA recombination (GO:0045911) NEW6.840.007PTPRC, IFNG
regulation of MAPK cascade (GO:0043408) NEW3.220.047KRT18, PTPRC, CCR5, KRT8, IFNG
hepatocyte apoptotic process (GO:0097284) -7.160.013KRT18, KRT8
T cell costimulation (GO:0031295) NEW5.350.032CCR5, PTPRC, IFNG
lymphocyte costimulation (GO:0031294) NEW5.330.032CCR5, PTPRC, IFNG
response to cytokine (GO:0034097) NEW3.840.014KRT18, CCR5, KRT8, IFNG
response to tumor necrosis factor (GO:0034612) NEW4.930.003KRT18, CCR5, KRT8, IFNG
negative regulation of sequestering of calcium ion (GO:0051283) -6.040.027CCR5, PTPRC
regulation of immunoglobulin production (GO:0002637) NEW5.860.045PTPRC, IFNG
regulation of immunoglobulin mediated immune response (GO:0002889) NEW6.040.009CCR5, PTPRC, IFNG
regulation of B cell mediated immunity (GO:0002712) NEW6.020.009CCR5, PTPRC, IFNG
regulation of cell growth (GO:0001558) NEW3.750.015KRT18, PTPRC, CCR5, KRT8, IFNG
response to other organism (GO:0051707) -3.480.017CCR5, IFNL3, PTPRC, IFNG, KRT8
multi-organism process (GO:0051704) -2.650.0KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
response to biotic stimulus (GO:0009607) -3.090.0CCR5, PTPRC, IFNL3, KRT8, IFNG
defense response to virus (GO:0051607) -4.630.007IFNL3, PTPRC, IFNG
response to external stimulus (GO:0009605) -2.550.008CCR5, IFNL3, PTPRC, IFNG, KRT8
cellular response to cytokine stimulus (GO:0071345) NEW4.330.007KRT18, CCR5, KRT8, IFNG
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) NEW4.350.025PTPRC, CCR5, KRT8, IFNG
positive regulation of T cell differentiation (GO:0045582) NEW5.520.035CCR5, PTPRC, IFNG
myeloid cell apoptotic process (GO:0033028) NEW7.940.011CCR5, IFNG
positive regulation of protein kinase activity (GO:0045860) NEW3.610.033KRT18, PTPRC, CCR5, KRT8, IFNG
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.116KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
extracellular region part (GO:0044421) 1.575KRT18, PTPRC, IFNL3, KRT8, IFNG
plasma membrane part (GO:0044459) 1.954PTPRC, CCR5, KRT8, IFNG
membrane-bounded organelle (GO:0043227) 0.474KRT18, CCR5, PTPRC, KRT8
organelle (GO:0043226) 0.44KRT18, CCR5, PTPRC, KRT8
membrane part (GO:0044425) 0.954PTPRC, CCR5, KRT8, IFNG
cytoplasm (GO:0005737) 1.013KRT18, CCR5, KRT8
external side of plasma membrane (GO:0009897) 4.463CCR5, PTPRC, IFNG
intracellular (GO:0005622) 2.373IFNL3, PTPRC, IFNG
extracellular organelle (GO:0043230) 1.893KRT18, PTPRC, KRT8
extracellular exosome (GO:0070062) 1.893KRT18, PTPRC, KRT8
membrane (GO:0016020) 0.683CCR5, PTPRC, KRT8
cytoplasmic part (GO:0044444) 0.823KRT18, CCR5, KRT8
membrane-bounded vesicle (GO:0031988) 1.713KRT18, PTPRC, KRT8
intracellular organelle (GO:0043229) 0.513KRT18, CCR5, KRT8
plasma membrane (GO:0005886) 1.393CCR5, PTPRC, KRT8
side of membrane (GO:0098552) 4.223CCR5, PTPRC, IFNG
intracellular part (GO:0044424) 0.283KRT18, CCR5, KRT8
extracellular vesicle (GO:1903561) 1.893KRT18, PTPRC, KRT8
intracellular membrane-bounded organelle (GO:0043231) 0.63KRT18, CCR5, KRT8
vesicle (GO:0031982) 1.643KRT18, PTPRC, KRT8
nuclear part (GO:0044428) 1.552KRT18, KRT8
intermediate filament (GO:0005882) 4.482KRT18, KRT8
supramolecular fiber (GO:0099512) 3.312KRT18, KRT8
polymeric cytoskeletal fiber (GO:0099513) 3.312KRT18, KRT8
integral component of membrane (GO:0016021) 1.142CCR5, PTPRC
keratin filament (GO:0045095) 5.212KRT18, KRT8
organelle part (GO:0044422) 0.792KRT18, KRT8
intracellular organelle part (GO:0044446) 0.812KRT18, KRT8
cell surface (GO:0009986) 3.442CCR5, PTPRC
cell periphery (GO:0071944) 5.782KRT18, KRT8
cell junction (GO:0030054) 2.752PTPRC, KRT8
cytoskeletal part (GO:0044430) 2.492KRT18, KRT8
integral component of plasma membrane (GO:0005887) 2.572CCR5, PTPRC
extracellular region (GO:0005576) 2.182IFNL3, IFNG
intrinsic component of plasma membrane (GO:0031226) 2.532CCR5, PTPRC
nucleus (GO:0005634) 1.072KRT18, KRT8
intrinsic component of membrane (GO:0031224) 1.132CCR5, PTPRC
extracellular space (GO:0005615) 2.632IFNL3, IFNG

NET-GE enrichment

Term New enriched termICP valueGenes
plasma membrane region (GO:0098590) NEW2.970.002KRT18, PTPRC, CCR5, KRT8, IFNG
anchoring junction (GO:0070161) NEW3.610.028PTPRC, KRT18, KRT8, IFNG
extracellular space (GO:0005615) -2.630.006KRT18, IFNG, KRT8, PTPRC, IFNL3, CCR5
external side of plasma membrane (GO:0009897) -4.460.001CCR5, PTPRC, IFNG
apical plasma membrane (GO:0016324) NEW4.130.01KRT18, CCR5, PTPRC, IFNG
keratin filament (GO:0045095) -5.210.023KRT18, KRT8
cell projection membrane (GO:0031253) NEW4.110.01KRT18, CCR5, PTPRC, IFNG
cell-cell junction (GO:0005911) NEW3.850.016PTPRC, KRT18, KRT8, IFNG
side of membrane (GO:0098552) -4.220.002CCR5, PTPRC, IFNG