Disease table of HEPATITIS B VIRUS, SUSCEPTIBILITY TO OMIM ID: 610424

Gene-disease associations table

GeneAssociated with HEPATITIS B VIRUS, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IFNAR2ClinVar, OMIMHGNC link21q22.112616669, 610424
IFNGR1ClinVar, OMIMHGNC link6q23.35209950, 600263, 615978, 607948, 610424
IL10RBClinVar, OMIMHGNC link21q22.112PS266600, 610424

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 9242IFNAR2, IL10RB
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
21q22.112IFNAR2, IL10RB
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
21q222IFNAR2, IL10RB
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
21q22IFNAR2, IL10RB
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
21q2IFNAR2, IL10RB
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
212IFNAR2, IL10RB
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IFNGR1YES2SP1, IRF20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IFNAR2IFNGR1No2JAK1, STAT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Cytokine-cytokine receptor interactionhsa040604.673IL10RB, IFNGR1, IFNAR2
Jak-STAT signaling pathwayhsa046305.443IL10RB, IFNGR1, IFNAR2
Natural killer cell mediated cytotoxicityhsa046505.532IFNGR1, IFNAR2
Toxoplasmosishsa051455.712IL10RB, IFNGR1
Osteoclast differentiationhsa043805.642IFNGR1, IFNAR2
Herpes simplex infectionhsa051685.082IFNGR1, IFNAR2
Tuberculosishsa051525.172IL10RB, IFNGR1
Influenza Ahsa051645.212IFNGR1, IFNAR2
Measleshsa051625.62IFNGR1, IFNAR2

NET-GE enrichment

Term New enriched termICP valueGenes
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.041IFNGR1, IFNAR2
Infectious diseases: ViralNEW3.290.032IL10RB, IFNGR1, IFNAR2
Tuberculosis (hsa05152) -5.170.004IL10RB, IFNGR1, IFNAR2
Osteoclast differentiation (hsa04380) -5.640.036IFNGR1, IFNAR2
Jak-STAT signaling pathway (hsa04630) -5.440.001IL10RB, IFNGR1, IFNAR2
Signaling molecules and interactionNEW3.090.048IL10RB, IFNGR1, IFNAR2
Measles (hsa05162) -5.60.038IFNGR1, IFNAR2
Toxoplasmosis (hsa05145) -5.710.032IL10RB, IFNGR1
Cytokine-cytokine receptor interaction (hsa04060) -4.670.008IL10RB, IFNGR1, IFNAR2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cytokine Signaling in Immune systemR-HSA-12802153.742IFNGR1, IFNAR2
Interferon SignalingR-HSA-9135314.952IFNGR1, IFNAR2
Immune SystemR-HSA-1682562.372IFNGR1, IFNAR2

NET-GE enrichment

Term New enriched termICP valueGenes
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.045IFNGR1, IFNAR2
Interferon Signaling (R-HSA-913531) -4.950.008IFNGR1, IFNAR2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
signaling receptor activity (GO:0038023) 2.493IL10RB, IFNGR1, IFNAR2
signal transducer activity (GO:0004871) 2.283IL10RB, IFNGR1, IFNAR2
molecular transducer activity (GO:0060089) 2.323IL10RB, IFNGR1, IFNAR2
transmembrane signaling receptor activity (GO:0004888) 2.573IL10RB, IFNGR1, IFNAR2
binding (GO:0005488) 0.183IL10RB, IFNGR1, IFNAR2
protein binding (GO:0005515) 0.463IL10RB, IFNGR1, IFNAR2
cytokine receptor activity (GO:0004896) 5.243IL10RB, IFNGR1, IFNAR2
transmembrane receptor activity (GO:0099600) 2.533IL10RB, IFNGR1, IFNAR2
receptor activity (GO:0004872) 2.323IL10RB, IFNGR1, IFNAR2
cytokine binding (GO:0019955) 5.212IFNGR1, IFNAR2
interleukin-20 binding (GO:0042015) 8.132IFNGR1, IFNAR2
interferon receptor activity (GO:0004904) 8.132IFNGR1, IFNAR2

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine binding (GO:0019955) -5.210.001IFNGR1, IFNAR2
receptor activity (GO:0004872) -2.320.013IL10RB, IFNGR1, IFNAR2
interferon receptor activity (GO:0004904) -8.130.0IFNGR1, IFNAR2
cytokine receptor activity (GO:0004896) -5.240.013IFNGR1, IFNAR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to external stimulus (GO:0009605) 2.553IL10RB, IFNGR1, IFNAR2
response to biotic stimulus (GO:0009607) 3.093IL10RB, IFNGR1, IFNAR2
cytokine-mediated signaling pathway (GO:0019221) 3.63IL10RB, IFNGR1, IFNAR2
response to external biotic stimulus (GO:0043207) 3.133IL10RB, IFNGR1, IFNAR2
response to virus (GO:0009615) 4.213IL10RB, IFNGR1, IFNAR2
response to stimulus (GO:0050896) 1.223IL10RB, IFNGR1, IFNAR2
cellular process (GO:0009987) 0.263IL10RB, IFNGR1, IFNAR2
regulation of cellular process (GO:0050794) 0.53IL10RB, IFNGR1, IFNAR2
interspecies interaction between organisms (GO:0044419) 3.083IL10RB, IFNGR1, IFNAR2
multi-organism cellular process (GO:0044764) 3.143IL10RB, IFNGR1, IFNAR2
biological regulation (GO:0065007) 0.393IL10RB, IFNGR1, IFNAR2
signal transduction (GO:0007165) 1.283IL10RB, IFNGR1, IFNAR2
cell surface receptor signaling pathway (GO:0007166) 2.093IL10RB, IFNGR1, IFNAR2
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.153IL10RB, IFNGR1, IFNAR2
viral process (GO:0016032) 3.153IL10RB, IFNGR1, IFNAR2
response to other organism (GO:0051707) 3.483IL10RB, IFNGR1, IFNAR2
regulation of biological process (GO:0050789) 0.453IL10RB, IFNGR1, IFNAR2
multi-organism process (GO:0051704) 2.653IL10RB, IFNGR1, IFNAR2
regulation of immune response (GO:0050776) 2.982IFNGR1, IFNAR2
regulation of innate immune response (GO:0045088) 3.862IFNGR1, IFNAR2
regulation of cytokine-mediated signaling pathway (GO:0001959) 4.822IFNGR1, IFNAR2
regulation of signal transduction (GO:0009966) 1.842IFNGR1, IFNAR2
regulation of response to stress (GO:0080134) 2.532IFNGR1, IFNAR2
regulation of response to stimulus (GO:0048583) 1.542IFNGR1, IFNAR2
regulation of immune system process (GO:0002682) 2.52IFNGR1, IFNAR2
regulation of response to cytokine stimulus (GO:0060759) 4.772IFNGR1, IFNAR2
regulation of signaling (GO:0023051) 1.722IFNGR1, IFNAR2
regulation of cell communication (GO:0010646) 1.732IFNGR1, IFNAR2
regulation of defense response (GO:0031347) 3.112IFNGR1, IFNAR2

NET-GE enrichment

Term New enriched termICP valueGenes
response to cytokine (GO:0034097) NEW3.840.003IL10RB, IFNGR1, IFNAR2
response to biotic stimulus (GO:0009607) -3.090.003IL10RB, IFNGR1, IFNAR2
regulation of innate immune response (GO:0045088) -3.860.038IFNGR1, IFNAR2
regulation of cytokine-mediated signaling pathway (GO:0001959) -4.820.005IFNGR1, IFNAR2
cellular response to cytokine stimulus (GO:0071345) NEW4.330.002IL10RB, IFNGR1, IFNAR2
response to virus (GO:0009615) -4.210.009IL10RB, IFNGR1, IFNAR2
regulation of response to cytokine stimulus (GO:0060759) -4.770.006IFNGR1, IFNAR2
cytokine-mediated signaling pathway (GO:0019221) -3.60.027IL10RB, IFNGR1, IFNAR2
response to external biotic stimulus (GO:0043207) -3.130.003IL10RB, IFNGR1, IFNAR2
response to other organism (GO:0051707) -3.480.001IL10RB, IFNGR1, IFNAR2
response to external stimulus (GO:0009605) -2.550.027IL10RB, IFNGR1, IFNAR2
multi-organism process (GO:0051704) -2.650.024IL10RB, IFNGR1, IFNAR2
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
integral component of membrane (GO:0016021) 1.143IL10RB, IFNGR1, IFNAR2
membrane (GO:0016020) 0.683IL10RB, IFNGR1, IFNAR2
cell part (GO:0044464) 0.113IL10RB, IFNGR1, IFNAR2
plasma membrane (GO:0005886) 1.393IL10RB, IFNGR1, IFNAR2
membrane part (GO:0044425) 0.953IL10RB, IFNGR1, IFNAR2
plasma membrane part (GO:0044459) 1.953IL10RB, IFNGR1, IFNAR2
intrinsic component of membrane (GO:0031224) 1.133IL10RB, IFNGR1, IFNAR2
intrinsic component of plasma membrane (GO:0031226) 2.532IFNGR1, IFNAR2
extracellular region part (GO:0044421) 1.572IL10RB, IFNAR2
integral component of plasma membrane (GO:0005887) 2.572IFNGR1, IFNAR2