Disease table of INFLAMMATORY BOWEL DISEASE OMIM ID: PS266600

Gene-disease associations table

GeneAssociated with INFLAMMATORY BOWEL DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IL10RAOMIM, HUMSAVARHGNC link11q23.31PS266600
IL10RBClinVar, OMIMHGNC link21q22.112PS266600, 610424
SLC22A5ClinVarHGNC link5q31.12212140, PS266600
ATG16L1OMIMHGNC link2q37.11PS266600
IL6OMIMHGNC link7p15.35108010, 148000, 604302, 125853, PS266600
IRF5OMIMHGNC link7q32.13612251, 180300, PS266600
ABCB1OMIMHGNC link7q21.122PS266600, 120080
IL23ROMIM, HUMSAVARHGNC link1p31.32PS266600, PS177900
NOD2OMIMHGNC link16q12.14PS266600, 607507, 186580, 609464
IRGMClinVar, OMIMHGNC link5q33.12PS266600, 607948

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
5q32IRGM, SLC22A5
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
5q2IRGM, SLC22A5
7q2ABCB1, IRF5
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
52IRGM, SLC22A5
73IL6, ABCB1, IRF5
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
IRF5YES2TNF, IFNA10
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2IL6, ABCB1
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC2IL6, ABCB1
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63IL6, NOD2, ABCB1
CEBPBNO60GADD45G, BCL2L1, IRF4, GOT1, PRL, DDIT3, CDKN1A, SMAD4, S100A9, SAA2, PTPN13, MMP1, F8, IL5RA, TFF3, ADM, CYP19A1, INSR, SFTPD, IL6, STAR, TNF, SMAD3, PCK2, IL1B, GNLY, FURIN, SAA1, SLC19A1, PTGS2, XBP1, HSF1, PRDM1, TNFAIP6, HP, IL24, IL10, SLC10A1, DAPK1, CSH2, OXTR, IL13, MAD1L1, CRP, CXCL8, SLC5A8, CSH1, HBB, ASNS, ALB, CSF3R, IL5, IL3, PRSS50, ABCB1, TOP1, GFER, IL4, CSRP1, FASLG2IL6, ABCB1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC13IL6, IRF5, ABCB1
EP300NO56ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD512IL6, ABCB1
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62IL6, ABCB1
NR1I2NO26BCL2L1, CYP2C9, FOSL1, PTAFR, TNFRSF12A, THRSP, ABCB1, THBS1, CYP2B6, CYP3A4, CYP2C8, NOD2, HP, IL10, CYP4F12, NOD1, UGT1A1, RELA, NFKB1, RXRA, FGF19, BCL2, CORO1C, CCL2, RAB3A, KLF62NOD2, ABCB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IL6YES29OTX2, TBP, ATF4, DDIT3, JUND, REL, SP1, EGR1, EP300, KLF4, CREB1, ZMYND11, FOXO1, PPARA, XBP1, ZNF300, VDR, JUN, RELA, NFKB1, AHR, STAT1, STAT3, CEBPA, RBPJ, CEBPB, GBX2, MYC, ZFP360
IRF5YES2SP1, IRF30
ABCB1YES30NFYA, EAPP, TP53, TCF7L2, SP1, TCF4, NFKB1, NR1I2, E2F1, HIPK2, SIRT1, WT1, HSF1, HDAC1, NFYC, JUN, MBD1, RELA, EP300, ETS1, NFYB, UHRF1, EGR1, PITX2, YBX1, CEBPB, ZNRD1, HIF1A, CDX2, MYCN0
IL23RYES1TBX210
NOD2YES2NR1I2, NFKB10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IL10RAIL10RBYes0
SLC22A5ATG16L1No1ELAVL1
ATG16L1NOD2Yes6NOD2, IRGM, ATG16L1, NOD1, UBC, IKBKG
ATG16L1IRGMYes5ATG16L1, IRGM, NOD2, NOD1, ULK1
IRF5NOD2No3COPS6, TRAF6, BIRC3
NOD2IRGMYes4ATG16L1, NOD2, IRGM, NOD1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SLC22A5IL6No-1PPARA
ATG16L1IL6No-1UBC
ATG16L1IRF5No-1UBC
ATG16L1ABCB1No-1UBC
IL6IRF5Yesbinding, activation, expression12KAT2B, ATF3, RELA, IRF4, IL12A, TP53, JUN, ATF2, IL8, IL1B, UBC, ICAM1
IL6ABCB1No-10SP1, KAT2B, HSF1, EZH2, TP53, CEBPB, JUN, PRKCA, UBC, NR1I2
IL6IL23RYesactivation, binding31TYK2, OSM, IL11, JAK2, IL12RB1, CNTF, CSF3, CLCF1, IL4, TPO, IL15, SOCS3, SOCS1, IL1B, LEP, IL12A, IL7, CSF2, STAT5A, IFNA1, IL2, IL10, IL13, RELA, CTF1, NFKB1, STAT3, IL23A, CCL2, JAK1, IL22
IRF5ABCB1No-6KAT2B, EGR1, IFNA17, TP53, JUN, UBC
IRF5IL23RNo-6IFNB1, IL1B, IL12A, IL6, IFNA17, RELA
ABCB1IL23RNo-1IFNA17

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Tuberculosishsa051525.174IL6, IL10RA, NOD2, IL10RB
Cytokine-cytokine receptor interactionhsa040604.674IL23R, IL6, IL10RB, IL10RA
Jak-STAT signaling pathwayhsa046305.444IL23R, IL6, IL10RB, IL10RA
Inflammatory bowel disease (IBD)hsa053216.433IL23R, IL6, NOD2
Toxoplasmosishsa051455.713IL10RA, IL10RB, IRGM
TNF signaling pathwayhsa046685.962IL6, NOD2
Toll-like receptor signaling pathwayhsa046206.02IL6, IRF5
Epstein-Barr virus infectionhsa051694.972IL10RA, IL10RB
NOD-like receptor signaling pathwayhsa046216.882IL6, NOD2

NET-GE enrichment

Term New enriched termICP valueGenes
Infectious diseases: ParasiticNEW4.460.042IL6, IL10RB, IRGM, IL10RA
Inflammatory bowel disease (IBD) (hsa05321) -6.430.01IL23R, IL6, NOD2
Jak-STAT signaling pathway (hsa04630) -5.440.001IL23R, IL6, IL10RA, IRF5, IL10RB
Tuberculosis (hsa05152) -5.170.006IL6, IL10RA, NOD2, IL10RB
Toxoplasmosis (hsa05145) -5.710.044IL6, IL10RB, IRGM, IL10RA
Cytokine-cytokine receptor interaction (hsa04060) -4.670.024IL23R, IL6, IL10RB, IL10RA
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cytokine Signaling in Immune systemR-HSA-12802153.743IL6, IRF5, NOD2
Immune SystemR-HSA-1682562.373IL6, IRF5, NOD2
Cellular responses to stressR-HSA-22627524.562ATG16L1, IL6
Transmembrane transport of small moleculesR-HSA-3825513.792SLC22A5, ABCB1
Signaling by InterleukinsR-HSA-4491474.712IL6, NOD2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1810IL23R, IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IRGM, ATG16L1, IL6, IL10RA
protein binding (GO:0005515) 0.469IL23R, IRF5, NOD2, ABCB1, SLC22A5, IL10RB, ATG16L1, IL6, IL10RA
organic cyclic compound binding (GO:0097159) 1.055SLC22A5, IRF5, NOD2, IRGM, ABCB1
heterocyclic compound binding (GO:1901363) 1.065SLC22A5, IRF5, NOD2, IRGM, ABCB1
carbohydrate derivative binding (GO:0097367) 2.034SLC22A5, NOD2, IRGM, ABCB1
nucleotide binding (GO:0000166) 1.964SLC22A5, NOD2, IRGM, ABCB1
small molecule binding (GO:0036094) 1.894SLC22A5, NOD2, IRGM, ABCB1
purine ribonucleoside triphosphate binding (GO:0035639) 2.224SLC22A5, NOD2, IRGM, ABCB1
ribonucleotide binding (GO:0032553) 2.194SLC22A5, NOD2, IRGM, ABCB1
purine nucleoside binding (GO:0001883) 2.224SLC22A5, NOD2, IRGM, ABCB1
ribonucleoside binding (GO:0032549) 2.224SLC22A5, NOD2, IRGM, ABCB1
purine ribonucleotide binding (GO:0032555) 2.24SLC22A5, NOD2, IRGM, ABCB1
purine nucleotide binding (GO:0017076) 2.194SLC22A5, NOD2, IRGM, ABCB1
purine ribonucleoside binding (GO:0032550) 2.224SLC22A5, NOD2, IRGM, ABCB1
nucleoside phosphate binding (GO:1901265) 1.964SLC22A5, NOD2, IRGM, ABCB1
nucleoside binding (GO:0001882) 2.214SLC22A5, NOD2, IRGM, ABCB1
signaling receptor activity (GO:0038023) 2.493IL23R, IL10RB, IL10RA
adenyl nucleotide binding (GO:0030554) 2.43SLC22A5, NOD2, ABCB1
catalytic activity (GO:0003824) 1.053ATG16L1, IRGM, ABCB1
molecular transducer activity (GO:0060089) 2.323IL23R, IL10RA, IL10RB
transmembrane signaling receptor activity (GO:0004888) 2.573IL23R, IL10RA, IL10RB
adenyl ribonucleotide binding (GO:0032559) 2.413SLC22A5, NOD2, ABCB1
ATP binding (GO:0005524) 2.433SLC22A5, NOD2, ABCB1
signal transducer activity (GO:0004871) 2.283IL23R, IL10RB, IL10RA
receptor activity (GO:0004872) 2.323IL23R, IL10RB, IL10RA
transmembrane receptor activity (GO:0099600) 2.533IL23R, IL10RA, IL10RB
cytokine receptor activity (GO:0004896) 5.243IL23R, IL10RA, IL10RB
cytokine receptor binding (GO:0005126) 4.142IL23R, IL6
hydrolase activity (GO:0016787) 1.92IRGM, ABCB1
growth factor receptor binding (GO:0070851) 4.872IL23R, IL6
interleukin-10 receptor activity (GO:0004920) 8.642IL10RA, IL10RB
transporter activity (GO:0005215) 2.572SLC22A5, ABCB1
cytokine binding (GO:0019955) 5.212IL23R, IL10RA
drug transmembrane transporter activity (GO:0015238) 6.852SLC22A5, ABCB1
transmembrane transporter activity (GO:0022857) 2.822SLC22A5, ABCB1
protein domain specific binding (GO:0019904) 3.322SLC22A5, NOD2
drug transporter activity (GO:0090484) 6.692SLC22A5, ABCB1
receptor binding (GO:0005102) 2.432IL23R, IL6
active transmembrane transporter activity (GO:0022804) 3.852SLC22A5, ABCB1

NET-GE enrichment

Term New enriched termICP valueGenes
drug transmembrane transporter activity (GO:0015238) -6.850.022SLC22A5, ABCB1
drug transporter activity (GO:0090484) -6.690.04SLC22A5, ABCB1
GTP binding (GO:0005525) NEW3.780.035ATG16L1, IL6, IRGM, ABCB1, IRF5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.228IRF5, ABCB1, NOD2, IL10RB, IRGM, IL23R, IL6, IL10RA
cellular process (GO:0009987) 0.268IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IRGM, ATG16L1, IL6
biological regulation (GO:0065007) 0.398IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IL23R, IL6, IL10RA
regulation of biological process (GO:0050789) 0.458IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IL23R, IL6, IL10RA
immune system process (GO:0002376) 2.297IRF5, ABCB1, NOD2, IL10RB, IRGM, IL23R, IL6
multi-organism process (GO:0051704) 2.657IL23R, IRF5, NOD2, SLC22A5, IL10RB, ATG16L1, IL6
response to biotic stimulus (GO:0009607) 3.096IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
response to external biotic stimulus (GO:0043207) 3.136IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
response to external stimulus (GO:0009605) 2.556IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
regulation of cellular process (GO:0050794) 0.56IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
defense response (GO:0006952) 2.786IRF5, NOD2, IL10RB, IRGM, IL23R, IL6
response to stress (GO:0006950) 1.86IRF5, NOD2, IL10RB, IRGM, IL23R, IL6
signal transduction (GO:0007165) 1.286IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
immune response (GO:0006955) 2.866IRF5, NOD2, IL10RB, IRGM, IL23R, IL6
positive regulation of biological process (GO:0048518) 1.26IRF5, ABCB1, NOD2, SLC22A5, IL23R, IL6
response to chemical (GO:0042221) 1.986IRF5, ABCB1, NOD2, IL23R, IL6, IL10RA
response to oxygen-containing compound (GO:1901700) 2.575IL23R, IL6, IRF5, NOD2, IL10RA
regulation of multicellular organismal process (GO:0051239) 1.875SLC22A5, IL23R, IL6, IRF5, NOD2
positive regulation of multicellular organismal process (GO:0051240) 2.495SLC22A5, IL23R, IL6, IRF5, NOD2
transport (GO:0006810) 1.515SLC22A5, ATG16L1, IL6, NOD2, ABCB1
localization (GO:0051179) 1.45ATG16L1, SLC22A5, IL6, NOD2, ABCB1
interspecies interaction between organisms (GO:0044419) 3.085SLC22A5, ATG16L1, IL6, IRF5, IL10RB
multi-organism cellular process (GO:0044764) 3.145ATG16L1, SLC22A5, IL6, IL10RB, IRF5
defense response to other organism (GO:0098542) 3.755IL23R, IL6, IRF5, NOD2, IL10RB
cell surface receptor signaling pathway (GO:0007166) 2.095IL23R, IL6, IL10RA, IRF5, IL10RB
response to molecule of bacterial origin (GO:0002237) 3.995IL23R, IL10RA, NOD2, IL6, IRF5
establishment of localization (GO:0051234) 1.485SLC22A5, ATG16L1, IL6, NOD2, ABCB1
response to other organism (GO:0051707) 3.485IL23R, IL6, IL10RB, NOD2, IRF5
response to organic substance (GO:0010033) 2.25IL23R, IL6, NOD2, IL10RA, IRF5
cytokine-mediated signaling pathway (GO:0019221) 3.65IL23R, IL6, IL10RA, IRF5, IL10RB
inflammatory response (GO:0006954) 3.644IL23R, IL6, IL10RB, IRGM
positive regulation of metabolic process (GO:0009893) 1.744IL23R, IL6, IRF5, NOD2
regulation of metabolic process (GO:0019222) 1.024IL23R, IL6, IRF5, NOD2
positive regulation of cellular metabolic process (GO:0031325) 1.814IL23R, IL6, IRF5, NOD2
regulation of cellular metabolic process (GO:0031323) 1.074IL23R, IL6, IRF5, NOD2
single-organism process (GO:0044699) 0.484SLC22A5, IL6, NOD2, ABCB1
regulation of primary metabolic process (GO:0080090) 1.084IL23R, IL6, IRF5, NOD2
positive regulation of macromolecule metabolic process (GO:0010604) 1.814IL23R, IL6, IRF5, NOD2
organic substance metabolic process (GO:0071704) 0.634ATG16L1, SLC22A5, IRF5, NOD2
positive regulation of immune system process (GO:0002684) 2.964IL23R, IL6, NOD2, ABCB1
regulation of immune system process (GO:0002682) 2.54IL23R, IL6, NOD2, ABCB1
organic substance transport (GO:0071702) 2.154ATG16L1, SLC22A5, IL6, NOD2
regulation of macromolecule metabolic process (GO:0060255) 1.084IL23R, IL6, IRF5, NOD2
innate immune response (GO:0045087) 3.554IL23R, IRF5, NOD2, IRGM
single-organism transport (GO:0044765) 2.184SLC22A5, IL6, NOD2, ABCB1
metabolic process (GO:0008152) 0.584ATG16L1, SLC22A5, IRF5, NOD2
single-organism localization (GO:1902578) 2.094SLC22A5, IL6, NOD2, ABCB1
cellular metabolic process (GO:0044237) 0.694SLC22A5, ATG16L1, IRF5, NOD2
regulation of cytokine production (GO:0001817) 3.44IL23R, IL6, IRF5, NOD2
viral process (GO:0016032) 3.154ATG16L1, IL6, IL10RB, IRF5
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.154ATG16L1, IL6, IL10RB, IRF5
positive regulation of cellular process (GO:0048522) 1.34IL23R, IL6, IRF5, NOD2
positive regulation of cytokine production (GO:0001819) 3.824IL23R, IL6, IRF5, NOD2
regulation of phosphate metabolic process (GO:0019220) 2.353IL23R, IL6, NOD2
positive regulation of response to stimulus (GO:0048584) 2.183IL23R, IL6, NOD2
regulation of response to stimulus (GO:0048583) 1.543IL23R, IL6, NOD2
regulation of defense response (GO:0031347) 3.113IL23R, IL6, NOD2
positive regulation of cell adhesion (GO:0045785) 3.793IL23R, IL6, NOD2
regulation of signal transduction (GO:0009966) 1.843IL23R, IL6, NOD2
response to virus (GO:0009615) 4.213IL6, IL10RB, IRF5
response to bacterium (GO:0009617) 4.183IL23R, IL6, NOD2
negative regulation of biological process (GO:0048519) 1.333IL23R, IL6, NOD2
regulation of cell proliferation (GO:0042127) 2.413IL23R, IL6, NOD2
regulation of protein kinase activity (GO:0045859) 3.153IL23R, IL6, NOD2
regulation of cellular protein metabolic process (GO:0032268) 1.993IL23R, IL6, NOD2
regulation of RNA biosynthetic process (GO:2001141) 1.553IL6, IRF5, NOD2
regulation of phosphorylation (GO:0042325) 2.53IL23R, IL6, NOD2
positive regulation of phosphorylation (GO:0042327) 2.93IL23R, IL6, NOD2
response to organonitrogen compound (GO:0010243) 3.23IL6, IRF5, NOD2
positive regulation of biosynthetic process (GO:0009891) 2.293IL6, IRF5, NOD2
positive regulation of immune response (GO:0050778) 3.43IL23R, IL6, NOD2
nitrogen compound metabolic process (GO:0006807) 1.133ATG16L1, SLC22A5, IRF5
defense response to bacterium (GO:0042742) 4.313IL23R, IL6, NOD2
response to peptidoglycan (GO:0032494) 7.433IL6, IRF5, NOD2
response to lipopolysaccharide (GO:0032496) 4.033IL23R, IL6, IL10RA
regulation of apoptotic process (GO:0042981) 2.53IL6, IRF5, NOD2
cellular macromolecule metabolic process (GO:0044260) 0.933ATG16L1, IRF5, NOD2
regulation of kinase activity (GO:0043549) 3.073IL23R, IL6, NOD2
cellular component organization (GO:0016043) 1.243ATG16L1, IL6, NOD2
cellular component organization or biogenesis (GO:0071840) 1.223ATG16L1, IL6, NOD2
regulation of molecular function (GO:0065009) 1.783IL23R, IL6, NOD2
regulation of biological quality (GO:0065008) 1.683SLC22A5, IL6, NOD2
regulation of catalytic activity (GO:0050790) 1.973IL23R, IL6, NOD2
regulation of biosynthetic process (GO:0009889) 1.373IL6, IRF5, NOD2
positive regulation of intracellular signal transduction (GO:1902533) 2.953IL23R, IL6, NOD2
regulation of intracellular signal transduction (GO:1902531) 2.313IL23R, IL6, NOD2
defense response to virus (GO:0051607) 4.633IL6, IL10RB, IRF5
response to nitrogen compound (GO:1901698) 3.123IL6, IRF5, NOD2
positive regulation of protein modification process (GO:0031401) 2.73IL23R, IL6, NOD2
regulation of transferase activity (GO:0051338) 2.883IL23R, IL6, NOD2
regulation of transcription, DNA-templated (GO:0006355) 1.563IL6, IRF5, NOD2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393IL6, IRF5, NOD2
positive regulation of leukocyte activation (GO:0002696) 4.03IL23R, IL6, NOD2
positive regulation of signal transduction (GO:0009967) 2.53IL23R, IL6, NOD2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363IL6, IRF5, NOD2
regulation of response to external stimulus (GO:0032101) 3.063IL23R, IL6, NOD2
regulation of cell adhesion (GO:0030155) 3.273IL23R, IL6, NOD2
positive regulation of signaling (GO:0023056) 2.413IL23R, IL6, NOD2
cellular nitrogen compound metabolic process (GO:0034641) 1.223SLC22A5, ATG16L1, IRF5
regulation of signaling (GO:0023051) 1.723IL23R, IL6, NOD2
positive regulation of cell communication (GO:0010647) 2.413IL23R, IL6, NOD2
regulation of cell communication (GO:0010646) 1.733IL23R, IL6, NOD2
response to endogenous stimulus (GO:0009719) 2.793IL6, IRF5, NOD2
regulation of lymphocyte activation (GO:0051249) 3.733IL23R, IL6, NOD2
positive regulation of phosphorus metabolic process (GO:0010562) 2.783IL23R, IL6, NOD2
regulation of protein metabolic process (GO:0051246) 1.933IL23R, IL6, NOD2
positive regulation of protein metabolic process (GO:0051247) 2.433IL23R, IL6, NOD2
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.353IL23R, IL6, NOD2
positive regulation of cellular protein metabolic process (GO:0032270) 2.493IL23R, IL6, NOD2
regulation of protein modification process (GO:0031399) 2.323IL23R, IL6, NOD2
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013IL23R, IL6, NOD2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563IL6, IRF5, NOD2
regulation of macromolecule biosynthetic process (GO:0010556) 1.433IL6, IRF5, NOD2
positive regulation of T cell activation (GO:0050870) 4.393IL23R, IL6, NOD2
positive regulation of transcription, DNA-templated (GO:0045893) 2.563IL6, IRF5, NOD2
regulation of immune response (GO:0050776) 2.983IL23R, IL6, NOD2
positive regulation of lymphocyte activation (GO:0051251) 4.073IL23R, IL6, NOD2
regulation of RNA metabolic process (GO:0051252) 1.523IL6, IRF5, NOD2
positive regulation of RNA metabolic process (GO:0051254) 2.513IL6, IRF5, NOD2
macromolecule metabolic process (GO:0043170) 0.833ATG16L1, IRF5, NOD2
positive regulation of RNA biosynthetic process (GO:1902680) 2.543IL6, IRF5, NOD2
positive regulation of gene expression (GO:0010628) 2.353IL6, IRF5, NOD2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813IL6, IRF5, NOD2
regulation of response to stress (GO:0080134) 2.533IL23R, IL6, NOD2
positive regulation of cell proliferation (GO:0008284) 3.013IL23R, IL6, NOD2
positive regulation of cellular biosynthetic process (GO:0031328) 2.33IL6, IRF5, NOD2
regulation of cell activation (GO:0050865) 3.533IL23R, IL6, NOD2
regulation of cellular biosynthetic process (GO:0031326) 1.383IL6, IRF5, NOD2
positive regulation of cell activation (GO:0050867) 3.973IL23R, IL6, NOD2
regulation of T cell activation (GO:0050863) 4.053IL23R, IL6, NOD2
homeostatic process (GO:0042592) 2.613SLC22A5, IL6, NOD2
regulation of cell-cell adhesion (GO:0022407) 3.793IL23R, IL6, NOD2
regulation of cell death (GO:0010941) 2.433IL6, IRF5, NOD2
positive regulation of cell-cell adhesion (GO:0022409) 4.233IL23R, IL6, NOD2
regulation of leukocyte activation (GO:0002694) 3.63IL23R, IL6, NOD2
response to lipid (GO:0033993) 3.113IL23R, IL6, IL10RA
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463IL6, IRF5, NOD2
regulation of programmed cell death (GO:0043067) 2.493IL6, IRF5, NOD2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243IL6, IRF5, NOD2
regulation of gene expression (GO:0010468) 1.373IL6, IRF5, NOD2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353IL6, IRF5, NOD2
positive regulation of phosphate metabolic process (GO:0045937) 2.783IL23R, IL6, NOD2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433IL6, IRF5, NOD2
regulation of phosphorus metabolic process (GO:0051174) 2.353IL23R, IL6, NOD2
regulation of nucleic acid-templated transcription (GO:1903506) 1.553IL6, IRF5, NOD2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293IL6, IRF5, NOD2
primary metabolic process (GO:0044238) 0.693ATG16L1, IRF5, NOD2
response to peptide (GO:1901652) 3.943IL6, IRF5, NOD2
immune effector process (GO:0002252) 3.583IL6, IRF5, IL10RB
regulation of protein phosphorylation (GO:0001932) 2.573IL23R, IL6, NOD2
positive regulation of protein phosphorylation (GO:0001934) 2.953IL23R, IL6, NOD2
protein localization (GO:0008104) 2.362ATG16L1, NOD2
regulation of secretion (GO:0051046) 3.22IL6, NOD2
positive regulation of secretion (GO:0051047) 3.852IL6, NOD2
regulation of alpha-beta T cell differentiation (GO:0046637) 5.92IL23R, IL6
regulation of transport (GO:0051049) 2.242IL6, NOD2
positive regulation of alpha-beta T cell activation (GO:0046635) 5.762IL23R, IL6
regulation of alpha-beta T cell activation (GO:0046634) 5.482IL23R, IL6
positive regulation of defense response (GO:0031349) 3.832IL6, NOD2
organic cyclic compound biosynthetic process (GO:1901362) 1.662ATG16L1, IRF5
organic cyclic compound metabolic process (GO:1901360) 1.262ATG16L1, IRF5
RNA biosynthetic process (GO:0032774) 1.842ATG16L1, IRF5
nitrogen compound transport (GO:0071705) 3.542SLC22A5, IL6
cellular response to stimulus (GO:0051716) 1.972IL6, NOD2
positive regulation of inflammatory response (GO:0050729) 4.982IL6, NOD2
anatomical structure homeostasis (GO:0060249) 4.252IL6, NOD2
regulation of inflammatory response (GO:0050727) 4.032IL6, NOD2
positive regulation of molecular function (GO:0044093) 2.232IL6, NOD2
macromolecule localization (GO:0033036) 2.342ATG16L1, NOD2
regulation of interleukin-12 production (GO:0032655) 5.782IL23R, IRF5
regulation of interleukin-10 production (GO:0032653) 5.972IL23R, NOD2
regulation of type 2 immune response (GO:0002828) 6.472IL6, NOD2
positive regulation of transport (GO:0051050) 2.92IL6, NOD2
negative regulation of cell death (GO:0060548) 2.952IL6, NOD2
regulation of T cell proliferation (GO:0042129) 4.742IL23R, IL6
establishment of protein localization (GO:0045184) 2.532ATG16L1, NOD2
positive regulation of hemopoiesis (GO:1903708) 4.632IL23R, IL6
regulation of hemopoiesis (GO:1903706) 4.02IL23R, IL6
heterocycle metabolic process (GO:0046483) 1.312ATG16L1, IRF5
homeostasis of number of cells (GO:0048872) 4.982SLC22A5, IL6
single-multicellular organism process (GO:0044707) 1.782IL6, NOD2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622IL23R, IL6
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352IL23R, IL6
cellular response to stress (GO:0033554) 2.512IL6, NOD2
positive regulation of interleukin-12 production (GO:0032735) 6.232IL23R, IRF5
aromatic compound biosynthetic process (GO:0019438) 1.72ATG16L1, IRF5
cellular component assembly (GO:0022607) 2.142ATG16L1, NOD2
regulation of lymphocyte proliferation (GO:0050670) 4.462IL23R, IL6
positive regulation of type 2 immune response (GO:0002830) 7.092IL6, NOD2
secretion by cell (GO:0032940) 3.592IL6, NOD2
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842IL23R, IL6
regulation of mononuclear cell proliferation (GO:0032944) 4.452IL23R, IL6
defense response to Gram-negative bacterium (GO:0050829) 5.992IL23R, IL6
response to muramyl dipeptide (GO:0032495) 7.092IRF5, NOD2
positive regulation of protein transport (GO:0051222) 3.612IL6, NOD2
regulation of protein transport (GO:0051223) 3.122IL6, NOD2
organic substance biosynthetic process (GO:1901576) 1.342ATG16L1, IRF5
regulation of protein secretion (GO:0050708) 3.772IL6, NOD2
regulation of cytokine secretion (GO:0050707) 4.742IL6, NOD2
macromolecular complex assembly (GO:0065003) 2.552ATG16L1, NOD2
regulation of MAPK cascade (GO:0043408) 3.222IL6, NOD2
heterocycle biosynthetic process (GO:0018130) 1.72ATG16L1, IRF5
regulation of establishment of protein localization (GO:0070201) 3.022IL6, NOD2
response to cytokine (GO:0034097) 3.842IL23R, IL6
regulation of developmental process (GO:0050793) 2.12IL23R, IL6
cellular response to organic substance (GO:0071310) 2.782IL6, NOD2
positive regulation of MAPK cascade (GO:0043410) 3.572IL6, NOD2
regulation of STAT cascade (GO:1904892) 4.782IL23R, IL6
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722ATG16L1, IRF5
RNA metabolic process (GO:0016070) 1.592ATG16L1, IRF5
secretion (GO:0046903) 3.382IL6, NOD2
positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) 6.552IL23R, IL6
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592ATG16L1, IRF5
positive regulation of protein secretion (GO:0050714) 4.392IL6, NOD2
regulation of immune effector process (GO:0002697) 3.712IL23R, IL6
positive regulation of STAT cascade (GO:1904894) 5.442IL23R, IL6
positive regulation of immune effector process (GO:0002699) 4.692IL23R, IL6
positive regulation of response to external stimulus (GO:0032103) 4.172IL6, NOD2
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) 5.632IL23R, IL6
regulation of T cell differentiation (GO:0045580) 5.072IL23R, IL6
cellular biosynthetic process (GO:0044249) 1.372ATG16L1, IRF5
positive regulation of T cell differentiation (GO:0045582) 5.522IL23R, IL6
regulation of secretion by cell (GO:1903530) 3.282IL6, NOD2
cellular response to chemical stimulus (GO:0070887) 2.572IL6, NOD2
positive regulation of secretion by cell (GO:1903532) 3.932IL6, NOD2
positive regulation of establishment of protein localization (GO:1904951) 3.492IL6, NOD2
regulation of protein localization (GO:0032880) 2.882IL6, NOD2
nucleobase-containing compound metabolic process (GO:0006139) 1.352ATG16L1, IRF5
regulation of system process (GO:0044057) 3.532SLC22A5, IL6
negative regulation of multicellular organismal process (GO:0051241) 2.842IL23R, IL6
positive regulation of lymphocyte differentiation (GO:0045621) 5.352IL23R, IL6
regulation of T-helper cell differentiation (GO:0045622) 6.472IL23R, IL6
positive regulation of T-helper cell differentiation (GO:0045624) 6.842IL23R, IL6
cellular response to endogenous stimulus (GO:0071495) 3.332IL6, NOD2
multicellular organismal process (GO:0032501) 1.452IL6, NOD2
positive regulation of interleukin-17 production (GO:0032740) 7.162IL23R, NOD2
cell proliferation (GO:0008283) 3.232IL6, ABCB1
positive regulation of alpha-beta T cell differentiation (GO:0046638) 6.122IL23R, IL6
positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) 6.432IL23R, IL6
regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) 6.092IL23R, IL6
positive regulation of B cell activation (GO:0050871) 5.272IL6, NOD2
positive regulation of cell differentiation (GO:0045597) 3.012IL23R, IL6
regulation of cell differentiation (GO:0045595) 2.422IL23R, IL6
regulation of localization (GO:0032879) 1.942IL6, NOD2
transmembrane transport (GO:0055085) 2.722SLC22A5, ABCB1
protein oligomerization (GO:0051259) 3.712ATG16L1, NOD2
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852IL6, NOD2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292IL6, NOD2
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832IL6, NOD2
regulation of epithelial cell proliferation (GO:0050678) 4.062IL6, NOD2
positive regulation of epithelial cell proliferation (GO:0050679) 4.672IL6, NOD2
positive regulation of developmental process (GO:0051094) 2.772IL23R, IL6
response to drug (GO:0042493) 3.712IL6, ABCB1
positive regulation of lymphocyte proliferation (GO:0050671) 4.852IL23R, IL6
regulation of interleukin-6 production (GO:0032675) 5.082IL6, NOD2
regulation of lymphocyte differentiation (GO:0045619) 4.842IL23R, IL6
regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) 6.232IL23R, IL6
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562IL6, NOD2
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232IL6, NOD2
negative regulation of cytokine production (GO:0001818) 4.42IL23R, IL6
regulation of interleukin-17 production (GO:0032660) 6.642IL23R, NOD2
macromolecular complex subunit organization (GO:0043933) 2.142ATG16L1, NOD2
regulation of B cell activation (GO:0050864) 4.922IL6, NOD2
nucleic acid metabolic process (GO:0090304) 1.462ATG16L1, IRF5
positive regulation of cell death (GO:0010942) 3.322IL6, IRF5
drug transport (GO:0015893) 6.512SLC22A5, ABCB1
positive regulation of antigen processing and presentation (GO:0002579) 6.92NOD2, ABCB1
protein complex subunit organization (GO:0071822) 2.62ATG16L1, NOD2
regulation of antigen processing and presentation (GO:0002577) 6.552NOD2, ABCB1
regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516) 5.942IL23R, IL6
positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) 6.122IL23R, IL6
positive regulation of apoptotic process (GO:0043065) 3.382IL6, IRF5
regulation of leukocyte proliferation (GO:0070663) 4.42IL23R, IL6
negative regulation of apoptotic process (GO:0043066) 3.042IL6, NOD2
positive regulation of leukocyte proliferation (GO:0070665) 4.792IL23R, IL6
negative regulation of programmed cell death (GO:0043069) 3.022IL6, NOD2
positive regulation of programmed cell death (GO:0043068) 3.382IL6, IRF5
drug transmembrane transport (GO:0006855) 6.782SLC22A5, ABCB1
positive regulation of JAK-STAT cascade (GO:0046427) 5.442IL23R, IL6
regulation of JAK-STAT cascade (GO:0046425) 4.782IL23R, IL6
cellular aromatic compound metabolic process (GO:0006725) 1.32ATG16L1, IRF5
autophagy (GO:0006914) 3.822ATG16L1, IRGM
protein complex assembly (GO:0006461) 2.782ATG16L1, NOD2
positive regulation of T cell proliferation (GO:0042102) 5.162IL23R, IL6
biosynthetic process (GO:0009058) 1.322ATG16L1, IRF5
macromolecule biosynthetic process (GO:0009059) 1.612ATG16L1, IRF5
single-organism cellular process (GO:0044763) 0.652IL6, NOD2
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) 5.492IL23R, IL6
cellular response to oxygen-containing compound (GO:1901701) 3.222IL6, NOD2
positive regulation of leukocyte differentiation (GO:1902107) 4.852IL23R, IL6
regulation of leukocyte differentiation (GO:1902105) 4.262IL23R, IL6
regulation of multicellular organismal development (GO:2000026) 2.312IL23R, IL6
positive regulation of interleukin-6 production (GO:0032755) 5.512IL6, NOD2
protein transport (GO:0015031) 2.622ATG16L1, NOD2
negative regulation of cellular process (GO:0048523) 1.412IL6, NOD2

NET-GE enrichment

Term New enriched termICP valueGenes
modulation by symbiont of host immune response (GO:0052553) NEW9.040.046IL6, NOD2
cytokine-mediated signaling pathway (GO:0019221) -3.60.001IL23R, IL6, IL10RB, IRF5, IL10RA
regulation of response to external stimulus (GO:0032101) -3.060.037IRF5, NOD2, ABCB1, IL10RB, IL23R, IL6, IL10RA
regulation of defense response to virus (GO:0050688) NEW4.530.005IL23R, IL6, IRF5, IL10RB
positive regulation by organism of defense response of other organism involved in symbiotic interaction (GO:0052510) NEW9.040.046IL6, NOD2
regulation of interferon-gamma production (GO:0032649) NEW5.210.018IL23R, IL6, IRF5, NOD2
regulation of memory T cell differentiation (GO:0043380) NEW7.530.039IL23R, IL6
positive regulation of memory T cell differentiation (GO:0043382) NEW7.780.021IL23R, IL6
response to peptidoglycan (GO:0032494) -7.430.0IL6, IRF5, NOD2
response to muramyl dipeptide (GO:0032495) -7.090.016IRF5, NOD2
response to lipopolysaccharide (GO:0032496) -4.030.004IL23R, IL6, IL10RA, NOD2, IRF5
mucosal immune response (GO:0002385) NEW6.590.012IL6, IL10RB, NOD2
modulation by organism of immune response of other organism involved in symbiotic interaction (GO:0052552) NEW9.040.046IL6, NOD2
microglial cell activation involved in immune response (GO:0002282) NEW9.040.039IL6, NOD2
regulation of response to biotic stimulus (GO:0002831) NEW4.30.001IL23R, IL6, IRF5, NOD2, IL10RB
response to external biotic stimulus (GO:0043207) -3.130.0IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
response to virus (GO:0009615) -4.210.042IL23R, IL6, IL10RB, IRF5, IL10RA
positive regulation of multicellular organismal process (GO:0051240) -2.490.007SLC22A5, IL23R, IL6, IRF5, NOD2
modulation by symbiont of host defense response (GO:0052031) NEW9.040.046IL6, NOD2
positive regulation of T-helper 17 type immune response (GO:2000318) NEW7.780.021IL23R, IL6
regulation of T-helper 17 type immune response (GO:2000316) NEW7.430.033IL23R, IL6
regulation of defense response (GO:0031347) -3.110.005IRF5, NOD2, ABCB1, IL10RB, IL23R, IL6, IL10RA
response to molecule of bacterial origin (GO:0002237) -3.990.0IL23R, IL6, IRF5, NOD2, IL10RA
regulation of interleukin-10 production (GO:0032653) -5.970.0IL23R, IL6, IRF5, NOD2
drug transport (GO:0015893) -6.510.003SLC22A5, IL6, ABCB1
drug transmembrane transport (GO:0006855) -6.780.038SLC22A5, ABCB1
regulation of interleukin-12 production (GO:0032655) -5.780.001IL23R, IL6, IRF5, NOD2
positive regulation of interleukin-17 production (GO:0032740) -7.160.014IL23R, IL6, NOD2
response to cytokine (GO:0034097) -3.840.01IRF5, ABCB1, NOD2, IL10RB, IL23R, IL6, IL10RA
positive regulation of natural killer cell proliferation (GO:0032819) NEW7.780.033IL23R, IL6
regulation of defense response to virus by host (GO:0050691) NEW4.890.013IL23R, IL6, IRF5
defense response (GO:0006952) -2.780.021IRF5, NOD2, IL10RB, IRGM, IL23R, IL6
defense response to other organism (GO:0098542) -3.750.0IL23R, IL6, IRF5, NOD2, IL10RB
modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0052255) NEW9.040.046IL6, NOD2
inflammatory response (GO:0006954) -3.640.037NOD2, IL10RB, IRGM, IL23R, IL6, IL10RA
response to other organism (GO:0051707) -3.480.002IL23R, IL6, IRF5, NOD2, IL10RB
positive regulation by symbiont of host defense response (GO:0052509) NEW9.040.046IL6, NOD2
multi-organism process (GO:0051704) -2.650.001IL23R, IRF5, NOD2, SLC22A5, IL10RB, ATG16L1, IL6
response to biotic stimulus (GO:0009607) -3.090.0IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
response to external stimulus (GO:0009605) -2.550.024IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
cellular response to cytokine stimulus (GO:0071345) NEW4.330.005IRF5, NOD2, ABCB1, IL10RB, IL23R, IL6, IL10RA
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) -4.350.018IL23R, IL6, NOD2, IL10RB, ABCB1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) -4.620.045IL23R, IL6, NOD2
organ or tissue specific immune response (GO:0002251) NEW6.510.015IL6, IL10RB, NOD2
positive regulation of activation of Janus kinase activity (GO:0010536) NEW7.780.033IL23R, IL6
positive regulation of activation of JAK2 kinase activity (GO:0010535) NEW7.940.021IL23R, IL6
immune effector process (GO:0002252) -3.580.049IRF5, NOD2, IL10RB, IL23R, IL6, IL10RA
positive regulation of interleukin-12 production (GO:0032735) -6.230.0IL23R, IL6, IRF5, NOD2
regulation of interleukin-17 production (GO:0032660) -6.640.047IL23R, IL6, NOD2
positive regulation of cytokine production (GO:0001819) -3.820.009IL23R, IL6, IRF5, NOD2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1110IL23R, IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IRGM, ATG16L1, IL6, IL10RA
membrane part (GO:0044425) 0.958NOD2, ABCB1, SLC22A5, IL10RB, IRGM, IL23R, IL6, IL10RA
membrane (GO:0016020) 0.688IL23R, NOD2, ABCB1, SLC22A5, IRGM, ATG16L1, IL10RB, IL10RA
membrane-bounded organelle (GO:0043227) 0.477IRF5, ABCB1, NOD2, SLC22A5, IRGM, ATG16L1, IL10RB
organelle (GO:0043226) 0.47IRF5, ABCB1, NOD2, SLC22A5, IRGM, ATG16L1, IL10RB
plasma membrane (GO:0005886) 1.397ABCB1, NOD2, SLC22A5, IRGM, IL23R, IL10RB, IL10RA
plasma membrane part (GO:0044459) 1.956NOD2, SLC22A5, IL6, IRGM, IL23R, IL10RB
intracellular part (GO:0044424) 0.285ATG16L1, IL6, NOD2, IRF5, IRGM
integral component of membrane (GO:0016021) 1.145SLC22A5, IL23R, IL10RB, IL10RA, ABCB1
vesicle (GO:0031982) 1.645SLC22A5, IL10RB, NOD2, IRGM, ABCB1
intrinsic component of membrane (GO:0031224) 1.135SLC22A5, IL23R, IL10RB, IL10RA, ABCB1
cytoplasm (GO:0005737) 1.014ATG16L1, IL6, IRF5, NOD2
protein complex (GO:0043234) 1.514IL23R, IL6, IL10RB, NOD2
macromolecular complex (GO:0032991) 1.354IL23R, IL6, IL10RB, NOD2
cytoplasmic part (GO:0044444) 0.824ATG16L1, IRF5, NOD2, IRGM
intracellular organelle (GO:0043229) 0.514ATG16L1, IRF5, NOD2, IRGM
extracellular region part (GO:0044421) 1.574SLC22A5, IL6, IL10RB, ABCB1
intracellular organelle part (GO:0044446) 0.813ATG16L1, NOD2, IRGM
receptor complex (GO:0043235) 4.013IL23R, IL6, IL10RB
extracellular organelle (GO:0043230) 1.893SLC22A5, IL10RB, ABCB1
extracellular exosome (GO:0070062) 1.893SLC22A5, IL10RB, ABCB1
cytosol (GO:0005829) 1.683ATG16L1, IRF5, NOD2
plasma membrane receptor complex (GO:0098802) 4.633IL23R, IL6, IL10RB
membrane-bounded vesicle (GO:0031988) 1.713SLC22A5, IL10RB, ABCB1
plasma membrane protein complex (GO:0098797) 3.553IL23R, IL6, IL10RB
membrane protein complex (GO:0098796) 2.843IL23R, IL6, IL10RB
extracellular vesicle (GO:1903561) 1.893SLC22A5, IL10RB, ABCB1
organelle part (GO:0044422) 0.793ATG16L1, NOD2, IRGM
intracellular membrane-bounded organelle (GO:0043231) 0.63ATG16L1, IRF5, IRGM
plasma membrane region (GO:0098590) 2.972SLC22A5, NOD2
autophagosome membrane (GO:0000421) 6.542ATG16L1, IRGM
bounding membrane of organelle (GO:0098588) 2.392ATG16L1, IRGM
cell projection part (GO:0044463) 2.972SLC22A5, ATG16L1
vacuolar membrane (GO:0005774) 3.452ATG16L1, IRGM
vacuolar part (GO:0044437) 3.262ATG16L1, IRGM
whole membrane (GO:0098805) 2.852ATG16L1, IRGM
cell surface (GO:0009986) 3.442NOD2, ABCB1
organelle membrane (GO:0031090) 1.972ATG16L1, IRGM

NET-GE enrichment

Term New enriched termICP valueGenes
plasma membrane part (GO:0044459) -1.950.023IRF5, NOD2, ABCB1, SLC22A5, IL10RB, IRGM, IL23R, IL6, IL10RA
vacuolar part (GO:0044437) -3.260.014ATG16L1, IL6, IRGM, ABCB1, IRF5
autophagic vacuole membrane (GO:0000421) -6.540.002ATG16L1, IRGM
receptor complex (GO:0043235) -4.010.019IL23R, IL6, IL10RB