Disease table of MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO OMIM ID: 607948

Gene-disease associations table

Gene	Associated with MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CCL2	OMIM	HGNC link	17q12	3	609423, 607948, 182940
SLC11A1	OMIM	HGNC link	2q35	2	607948, 610446
IFNG	OMIM	HGNC link	12q15	5	609135, PS191100, 609532, 607948, 609423
MC3R	OMIM	HGNC link	20q13.2	2	602025, 607948
TIRAP	OMIM	HGNC link	11q24.2	4	611162, PS610799, 607948, 614382
TLR2	OMIM	HGNC link	4q31.3	3	114500, 607948, 246300
CD209	OMIM	HGNC link	19p13.2	3	609423, 607948, 614371
CISH	OMIM	HGNC link	3p21.2	3	614383, 607948, 611162
SP110	OMIM	HGNC link	2q37.1	2	235550, 607948
IRGM	OMIM	HGNC link	5q33.1	2	PS266600, 607948
IFNGR1	OMIM	HGNC link	6q23.3	5	209950, 600263, 615978, 607948, 610424

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
2q3	2	SP110, SLC11A1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	2	SP110, SLC11A1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
2	2	SP110, SLC11A1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	CISH, IFNG
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	IFNG, CCL2
JUN	NO	155	PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC	2	IFNG, CCL2
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	TLR2, IFNG, CCL2
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	TLR2, IFNG, CCL2
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	IFNGR1, TLR2, CCL2

regulated gene	associated to this disease	# TFs	TFs
CCL2	YES	17	SP1, XBP1, NFAT5, NFKB1, PREB, HEY1, HDAC2, NFIC, NR1I2, ATF4, JUN, IRF3, RELA, APEX1, MAML1, REL, STAT1
IFNG	YES	29	BCL6, TFAP4, NFATC2, TBX21, EGR1, NFKB1, CREB1, STAT5A, NFATC1, JUN, GATA1, ATF2, RELA, PARP1, GATA3, EP300, STAT1, STAT3, PROX1, RFX5, EOMES, YY1, NFIL3, STAT5B, MSC, MYCN, STAT4, IRF1, USF1
TLR2	YES	4	SP1, NFKB1, HIF1A, RELA
CISH	YES	2	STAT3, STAT6
IFNGR1	YES	2	SP1, IRF2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CCL2	TIRAP	No	1	PCNA
IFNG	IFNGR1	Yes	1	IFNG
TIRAP	TLR2	Yes	4	TIRAP, MYD88, IRAK1, TLR2
TIRAP	CISH	No	1	MYD88
TIRAP	IFNGR1	No	1	JAK1
TLR2	CD209	No	1	CLEC4M
TLR2	CISH	No	2	MYD88, EGFR
TLR2	IRGM	No	1	ATG16L1
CISH	IRGM	No	1	AMBRA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CCL2	IFNG	No	-	8	TYK2, IL23A, JUN, JAK2, IL23R, IL12RB1, TGFB1, FOS
CCL2	MC3R	No	-	1	PTH
CCL2	TIRAP	No	-	1	IL6
CCL2	TLR2	No	-	11	CSF2, IL4, MMP1, CXCR2, MMP9, MMP2, IL6, SRC, MAPK14, NFKB1, ICAM1
CCL2	CD209	No	-	4	SRC, TGFB1, IL4, IL10
CCL2	CISH	No	-	4	TYK2, FOS, JAK2, TP53
SLC11A1	IFNG	No	-	1	IRF1
IFNG	TIRAP	No	-	1	EIF2AK2
IFNG	TLR2	No	-	3	SOCS1, STAT3, RELA
IFNG	CD209	No	-	1	TGFB1
IFNG	CISH	No	-	15	STAT3, STAT5A, IL2, GHR, STAT6, FOS, SOCS3, JAK2, IL2RB, JAK1, PRLR, TYK2, SOCS1, STAT4, EPOR
MC3R	TLR2	No	-	1	VIP
TIRAP	TLR2	Yes	activation	13	HMGB1, IRAK2, IKBKB, TOLLIP, TRAF6, IL6, TLR1, CD14, TLR4, HSPD1, MAP3K7, CHUK, LY96
TIRAP	CISH	No	-	0
TLR2	CD209	No	-	2	SRC, IL4
TLR2	CISH	No	-	2	STAT3, SOCS1
CD209	CISH	No	-	1	LCK

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
IFNG	IFNGR1	Yes	2	IFNGR1, IFNG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Tuberculosis	hsa05152	5.17	5	TIRAP, IFNGR1, CD209, TLR2, IFNG
Chagas disease (American trypanosomiasis)	hsa05142	5.99	4	IFNGR1, TLR2, IFNG, CCL2
Herpes simplex infection	hsa05168	5.08	4	IFNGR1, IFNG, TLR2, CCL2
Measles	hsa05162	5.6	4	IFNGR1, CD209, TLR2, IFNG
Toxoplasmosis	hsa05145	5.71	4	IFNGR1, IRGM, IFNG, TLR2
Rheumatoid arthritis	hsa05323	6.05	3	IFNG, TLR2, CCL2
Inflammatory bowel disease (IBD)	hsa05321	6.43	3	IFNGR1, IFNG, TLR2
Jak-STAT signaling pathway	hsa04630	5.44	3	CISH, IFNGR1, IFNG
Leishmaniasis	hsa05140	6.32	3	IFNGR1, IFNG, TLR2
Malaria	hsa05144	7.15	3	IFNG, TLR2, CCL2
Influenza A	hsa05164	5.21	3	IFNGR1, CCL2, IFNG
Cytokine-cytokine receptor interaction	hsa04060	4.67	3	IFNGR1, CCL2, IFNG
Salmonella infection	hsa05132	6.29	2	IFNGR1, IFNG
Natural killer cell mediated cytotoxicity	hsa04650	5.53	2	IFNGR1, IFNG
Toll-like receptor signaling pathway	hsa04620	6.0	2	TIRAP, TLR2
Phagosome	hsa04145	5.27	2	CD209, TLR2
Osteoclast differentiation	hsa04380	5.64	2	IFNGR1, IFNG
HIF-1 signaling pathway	hsa04066	5.9	2	IFNGR1, IFNG
Amoebiasis	hsa05146	5.82	2	IFNG, TLR2
Hepatitis B	hsa05161	5.52	2	TIRAP, TLR2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Immune diseases	NEW	4.47	0.043	IFNGR1, IFNG, TLR2, CCL2
Salmonella infection (hsa05132)	-	6.29	0.008	IFNGR1, TLR2, IFNG, CCL2
Infectious diseases: Parasitic	NEW	4.46	0.002	TIRAP, IRGM, IFNG, IFNGR1, CCL2, TLR2
Infectious diseases: Bacterial	NEW	3.76	0.025	TIRAP, IFNGR1, CD209, TLR2, IFNG
Rheumatoid arthritis (hsa05323)	-	6.05	0.023	IFNG, TLR2, CCL2
Infectious diseases: Viral	NEW	3.29	0.01	TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
Inflammatory bowel disease (IBD) (hsa05321)	-	6.43	0.011	IFNGR1, IFNG, TLR2
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.007	TIRAP, TLR2, IFNG, CCL2
Chagas disease (American trypanosomiasis) (hsa05142)	-	5.99	0.01	IFNGR1, TLR2, IFNG, CCL2
Leishmaniasis (hsa05140)	-	6.32	0.013	IFNGR1, IFNG, TLR2
Herpes simplex infection (hsa05168)	-	5.08	0.009	IFNGR1, IFNG, TLR2, CCL2
Malaria (hsa05144)	-	7.15	0.036	IFNG, TLR2, CCL2
Tuberculosis (hsa05152)	-	5.17	0.013	TIRAP, IFNGR1, CD209, TLR2, IFNG
NF-kappa B signaling pathway (hsa04064)	NEW	6.21	0.004	IFNG, TIRAP, TLR2, CCL2
Toxoplasmosis (hsa05145)	-	5.71	0.001	IFNGR1, IRGM, TIRAP, IFNG, TLR2
Measles (hsa05162)	-	5.6	0.029	IFNGR1, CD209, TLR2, IFNG

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	6	TIRAP, CISH, CD209, IFNG, IFNGR1, TLR2
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	CISH, IFNGR1, IFNG
Innate Immune System	R-HSA-168249	3.17	3	TIRAP, CD209, TLR2
Disease	R-HSA-1643685	3.33	3	SLC11A1, TIRAP, TLR2
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56	2	TIRAP, TLR2
Regulation of IFNG signaling	R-HSA-877312	9.18	2	IFNGR1, IFNG
Signaling by GPCR	R-HSA-372790	2.68	2	MC3R, CCL2
Diseases of Immune System	R-HSA-5260271	8.34	2	TIRAP, TLR2
MyD88 deficiency (TLR2/4)	R-HSA-5602498	9.52	2	TIRAP, TLR2
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	MC3R, CCL2
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51	2	TIRAP, TLR2
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11	2	TIRAP, TLR2
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51	2	TIRAP, TLR2
Peptide ligand-binding receptors	R-HSA-375276	5.41	2	MC3R, CCL2
Toll-Like Receptors Cascades	R-HSA-168898	5.91	2	TIRAP, TLR2
Interferon Signaling	R-HSA-913531	4.95	2	IFNGR1, IFNG
Diseases associated with the TLR signaling cascade	R-HSA-5602358	8.34	2	TIRAP, TLR2
Interferon gamma signaling	R-HSA-877300	5.67	2	IFNGR1, IFNG
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56	2	TIRAP, TLR2
IRAK4 deficiency (TLR2/4)	R-HSA-5603041	9.52	2	TIRAP, TLR2
Activated TLR4 signalling	R-HSA-166054	6.27	2	TIRAP, TLR2
GPCR ligand binding	R-HSA-500792	4.19	2	MC3R, CCL2
Signal Transduction	R-HSA-162582	1.78	2	MC3R, CCL2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
MyD88 deficiency (TLR2/4) (R-HSA-5602498)	-	9.52	0.003	TIRAP, TLR2
Regulation of IFNG signaling (R-HSA-877312)	-	9.18	0.004	IFNGR1, IFNG
Toll-Like Receptors Cascades (R-HSA-168898)	-	5.91	0.012	TIRAP, TLR2, CCL2, IFNG
IRAK4 deficiency (TLR2/4) (R-HSA-5603041)	-	9.52	0.005	TIRAP, TLR2
Diseases associated with the TLR signaling cascade (R-HSA-5602358)	-	8.34	0.014	TIRAP, TLR2
Diseases of Immune System (R-HSA-5260271)	-	8.34	0.014	TIRAP, TLR2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	11	IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
protein binding (GO:0005515)	0.46	9	IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
molecular transducer activity (GO:0060089)	2.32	4	IFNGR1, CD209, MC3R, TLR2
receptor binding (GO:0005102)	2.43	4	TIRAP, TLR2, IFNG, CCL2
receptor activity (GO:0004872)	2.32	4	IFNGR1, CD209, MC3R, TLR2
signal transducer activity (GO:0004871)	2.28	4	IFNGR1, MC3R, SP110, TLR2
signaling receptor activity (GO:0038023)	2.49	3	IFNGR1, MC3R, TLR2
carbohydrate derivative binding (GO:0097367)	2.03	3	IRGM, TLR2, CCL2
amide binding (GO:0033218)	4.14	3	CD209, MC3R, TLR2
transmembrane signaling receptor activity (GO:0004888)	2.57	3	IFNGR1, MC3R, TLR2
peptide binding (GO:0042277)	4.22	3	CD209, MC3R, TLR2
protein dimerization activity (GO:0046983)	2.72	3	SLC11A1, TIRAP, TLR2
transmembrane receptor activity (GO:0099600)	2.53	3	IFNGR1, MC3R, TLR2
cytokine receptor binding (GO:0005126)	4.14	2	IFNG, CCL2
cation binding (GO:0043169)	1.4	2	CD209, SP110
cytokine activity (GO:0005125)	4.34	2	CCL2, IFNG
protein heterodimerization activity (GO:0046982)	3.64	2	TIRAP, TLR2
organic cyclic compound binding (GO:0097159)	1.05	2	IRGM, SP110
lipid binding (GO:0008289)	3.26	2	TIRAP, TLR2
ion binding (GO:0043167)	1.36	2	CD209, SP110
glycosaminoglycan binding (GO:0005539)	4.42	2	TLR2, CCL2
catalytic activity (GO:0003824)	1.05	2	IRGM, CCL2
small molecule binding (GO:0036094)	1.89	2	CD209, IRGM
Toll-like receptor binding (GO:0035325)	7.66	2	TIRAP, TLR2
metal ion binding (GO:0046872)	1.41	2	CD209, SP110
heterocyclic compound binding (GO:1901363)	1.06	2	IRGM, SP110
identical protein binding (GO:0042802)	2.63	2	SLC11A1, TIRAP
protein homodimerization activity (GO:0042803)	3.16	2	SLC11A1, TIRAP

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
amide binding (GO:0033218)	-	4.14	0.04	CD209, MC3R, TLR2
molecular transducer activity (GO:0060089)	-	2.32	0.004	IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
peptide binding (GO:0042277)	-	4.22	0.037	CD209, MC3R, TLR2
signal transducer activity (GO:0004871)	-	2.28	0.004	IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
cytokine receptor activity (GO:0004896)	NEW	5.24	0.001	CISH, IFNGR1, TLR2, IFNG

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	10	IRGM, TIRAP, CISH, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
biological regulation (GO:0065007)	0.39	10	IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of biological process (GO:0050789)	0.45	10	IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of cellular process (GO:0050794)	0.5	10	IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
signal transduction (GO:0007165)	1.28	9	IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
regulation of primary metabolic process (GO:0080090)	1.08	8	CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of metabolic process (GO:0019222)	1.02	8	CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of cellular metabolic process (GO:0031323)	1.07	8	CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
response to stimulus (GO:0050896)	1.22	8	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of response to stimulus (GO:0048583)	1.54	8	TIRAP, CISH, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
multi-organism process (GO:0051704)	2.65	8	TIRAP, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
defense response (GO:0006952)	2.78	7	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of biosynthetic process (GO:0009889)	1.37	7	TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
immune system process (GO:0002376)	2.29	7	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
response to stress (GO:0006950)	1.8	7	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of immune system process (GO:0002682)	2.5	7	TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
cell surface receptor signaling pathway (GO:0007166)	2.09	7	TIRAP, CISH, CD209, IFNG, CCL2, IFNGR1, TLR2
immune response (GO:0006955)	2.86	7	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
positive regulation of biological process (GO:0048518)	1.2	7	CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
single-organism process (GO:0044699)	0.48	7	CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
regulation of phosphate metabolic process (GO:0019220)	2.35	6	CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R
positive regulation of metabolic process (GO:0009893)	1.74	6	TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
positive regulation of biosynthetic process (GO:0009891)	2.29	6	TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
positive regulation of cellular metabolic process (GO:0031325)	1.81	6	TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
positive regulation of response to stimulus (GO:0048584)	2.18	6	TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of signaling (GO:0023051)	1.72	6	CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
regulation of cell communication (GO:0010646)	1.73	6	CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
regulation of defense response (GO:0031347)	3.11	6	TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
response to external biotic stimulus (GO:0043207)	3.13	6	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of signal transduction (GO:0009966)	1.84	6	CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
positive regulation of immune system process (GO:0002684)	2.96	6	TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of molecular function (GO:0065009)	1.78	6	CISH, TIRAP, IFNG, SLC11A1, CCL2, TLR2
regulation of biological quality (GO:0065008)	1.68	6	TIRAP, CD209, IFNG, SLC11A1, CCL2, MC3R
regulation of gene expression (GO:0010468)	1.37	6	TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of phosphorus metabolic process (GO:0051174)	2.35	6	CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R
single-organism cellular process (GO:0044763)	0.65	6	TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of multicellular organismal process (GO:0051239)	1.87	6	TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
response to other organism (GO:0051707)	3.48	6	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of immune response (GO:0050776)	2.98	6	TIRAP, CD209, IFNG, SLC11A1, IFNGR1, TLR2
response to biotic stimulus (GO:0009607)	3.09	6	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
response to external stimulus (GO:0009605)	2.55	6	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of response to stress (GO:0080134)	2.53	6	TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	TIRAP, SP110, SLC11A1, IFNG, CCL2, TLR2
positive regulation of cellular process (GO:0048522)	1.3	6	TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
metabolic process (GO:0008152)	0.58	5	SLC11A1, CISH, TLR2, SP110, CCL2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	5	SLC11A1, MC3R, TIRAP, IFNG, TLR2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	5	SLC11A1, SP110, TIRAP, IFNG, TLR2
regulation of localization (GO:0032879)	1.94	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	SLC11A1, IFNG, TIRAP, TLR2, CCL2
regulation of cytokine production (GO:0001817)	3.4	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	SLC11A1, IFNG, TIRAP, TLR2, CCL2
response to bacterium (GO:0009617)	4.18	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of protein metabolic process (GO:0051246)	1.93	5	SLC11A1, CISH, TIRAP, IFNG, CCL2
interspecies interaction between organisms (GO:0044419)	3.08	5	IFNGR1, IFNG, CD209, CCL2, SP110
organic substance metabolic process (GO:0071704)	0.63	5	SLC11A1, CISH, TLR2, CCL2, SP110
positive regulation of molecular function (GO:0044093)	2.23	5	SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of protein modification process (GO:0031399)	2.32	5	SLC11A1, CISH, TIRAP, IFNG, CCL2
negative regulation of biological process (GO:0048519)	1.33	5	SLC11A1, CISH, TIRAP, CCL2, IFNG
response to oxygen-containing compound (GO:1901700)	2.57	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of innate immune response (GO:0045088)	3.86	5	CD209, IFNGR1, TIRAP, IFNG, TLR2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	5	SLC11A1, MC3R, TIRAP, IFNG, CCL2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	SLC11A1, TIRAP, TLR2, IFNG, SP110
multi-organism cellular process (GO:0044764)	3.14	5	IFNGR1, SP110, CD209, CCL2, IFNG
inflammatory response (GO:0006954)	3.64	5	SLC11A1, IRGM, TIRAP, TLR2, CCL2
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	SLC11A1, SP110, TIRAP, IFNG, TLR2
response to chemical (GO:0042221)	1.98	5	SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of intracellular signal transduction (GO:1902531)	2.31	5	CISH, IFNG, TIRAP, TLR2, CCL2
response to organic substance (GO:0010033)	2.2	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of phosphorylation (GO:0042325)	2.5	5	SLC11A1, CISH, TIRAP, CCL2, IFNG
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	SLC11A1, CISH, TIRAP, IFNG, CCL2
regulation of RNA metabolic process (GO:0051252)	1.52	5	SLC11A1, SP110, TIRAP, IFNG, TLR2
positive regulation of immune response (GO:0050778)	3.4	5	SLC11A1, TIRAP, CD209, TLR2, IFNG
macromolecule metabolic process (GO:0043170)	0.83	5	SLC11A1, CISH, SP110, TLR2, CCL2
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	SLC11A1, IFNG, TIRAP, TLR2, SP110
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	5	SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to molecule of bacterial origin (GO:0002237)	3.99	5	SLC11A1, TIRAP, IFNG, TLR2, CCL2
viral process (GO:0016032)	3.15	5	IFNGR1, SP110, CD209, CCL2, IFNG
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	5	IFNGR1, SP110, CD209, CCL2, IFNG
regulation of protein phosphorylation (GO:0001932)	2.57	5	SLC11A1, CISH, TIRAP, CCL2, IFNG
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	5	SLC11A1, MC3R, TIRAP, CCL2, IFNG
positive regulation of cytokine production (GO:0001819)	3.82	5	SLC11A1, TIRAP, IFNG, TLR2, CCL2
primary metabolic process (GO:0044238)	0.69	4	CISH, TLR2, SP110, CCL2
cytokine-mediated signaling pathway (GO:0019221)	3.6	4	CISH, IFNGR1, IFNG, CCL2
regulation of cell activation (GO:0050865)	3.53	4	TIRAP, CD209, IFNG, CCL2
regulation of transport (GO:0051049)	2.24	4	SLC11A1, TLR2, IFNG, CCL2
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)	5.1	4	TIRAP, IFNG, TLR2, CCL2
regulation of cellular component organization (GO:0051128)	2.01	4	SLC11A1, CISH, IFNG, CCL2
positive regulation of defense response (GO:0031349)	3.83	4	TIRAP, CD209, TLR2, CCL2
multicellular organismal process (GO:0032501)	1.45	4	SLC11A1, MC3R, TLR2, IFNG
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)	5.67	4	IFNG, TIRAP, TLR2, CCL2
defense response to bacterium (GO:0042742)	4.31	4	SLC11A1, TIRAP, TLR2, IFNG
cellular response to chemical stimulus (GO:0070887)	2.57	4	IFNG, TIRAP, TLR2, CCL2
response to lipopolysaccharide (GO:0032496)	4.03	4	SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cell communication (GO:0010647)	2.41	4	TIRAP, IFNG, TLR2, CCL2
cellular response to stimulus (GO:0051716)	1.97	4	TIRAP, TLR2, IFNG, CCL2
regulation of lymphocyte activation (GO:0051249)	3.73	4	TIRAP, CD209, IFNG, CCL2
immune response-regulating signaling pathway (GO:0002764)	3.72	4	TIRAP, CD209, TLR2, IFNG
cellular macromolecule metabolic process (GO:0044260)	0.93	4	CISH, SP110, CCL2, TLR2
regulation of tumor necrosis factor production (GO:0032680)	5.13	4	IFNG, TIRAP, TLR2, CCL2
response to lipid (GO:0033993)	3.11	4	SLC11A1, TIRAP, IFNG, CCL2
positive regulation of protein metabolic process (GO:0051247)	2.43	4	SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	4	SLC11A1, TIRAP, IFNG, CCL2
cellular response to molecule of bacterial origin (GO:0071219)	4.88	4	TIRAP, IFNG, TLR2, CCL2
organic substance transport (GO:0071702)	2.15	4	SLC11A1, CD209, IFNG, TLR2
cellular response to biotic stimulus (GO:0071216)	4.76	4	IFNG, TIRAP, TLR2, CCL2
biological adhesion (GO:0022610)	2.81	4	SLC11A1, CD209, CCL2, IFNG
regulation of cell proliferation (GO:0042127)	2.41	4	TIRAP, CD209, IFNG, CCL2
positive regulation of tumor necrosis factor production (GO:0032760)	5.7	4	IFNG, TIRAP, TLR2, CCL2
transport (GO:0006810)	1.51	4	SLC11A1, CD209, TLR2, IFNG
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	SLC11A1, MC3R, IFNG, TLR2
positive regulation of transport (GO:0051050)	2.9	4	SLC11A1, TLR2, IFNG, CCL2
innate immune response (GO:0045087)	3.55	4	TIRAP, CD209, IRGM, TLR2
regulation of catalytic activity (GO:0050790)	1.97	4	SLC11A1, CISH, CCL2, IFNG
defense response to other organism (GO:0098542)	3.75	4	SLC11A1, TIRAP, IFNG, TLR2
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	SLC11A1, MC3R, IFNG, TLR2
cell adhesion (GO:0007155)	2.82	4	SLC11A1, CD209, CCL2, IFNG
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	IFNG, TIRAP, TLR2, CCL2
establishment of localization (GO:0051234)	1.48	4	SLC11A1, CD209, IFNG, TLR2
localization (GO:0051179)	1.4	4	SLC11A1, CD209, IFNG, TLR2
positive regulation of signaling (GO:0023056)	2.41	4	IFNG, TIRAP, TLR2, CCL2
cellular response to oxygen-containing compound (GO:1901701)	3.22	4	TIRAP, TLR2, IFNG, CCL2
positive regulation of phosphorylation (GO:0042327)	2.9	4	SLC11A1, TIRAP, IFNG, CCL2
immune response-activating signal transduction (GO:0002757)	3.8	4	TIRAP, CD209, IFNG, TLR2
positive regulation of protein modification process (GO:0031401)	2.7	4	SLC11A1, TIRAP, IFNG, CCL2
cellular metabolic process (GO:0044237)	0.69	4	CISH, SP110, TLR2, CCL2
regulation of leukocyte activation (GO:0002694)	3.6	4	TIRAP, CD209, CCL2, IFNG
activation of immune response (GO:0002253)	3.67	4	TIRAP, CD209, TLR2, IFNG
positive regulation of signal transduction (GO:0009967)	2.5	4	IFNG, TIRAP, TLR2, CCL2
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cellular component organization (GO:0051130)	2.68	3	SLC11A1, CCL2, IFNG
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	3	SLC11A1, IFNG, TLR2
protein localization (GO:0008104)	2.36	3	SLC11A1, IFNG, TLR2
single organismal cell-cell adhesion (GO:0016337)	3.69	3	SLC11A1, CD209, IFNG
positive regulation of response to external stimulus (GO:0032103)	4.17	3	TIRAP, TLR2, CCL2
regulation of cellular localization (GO:0060341)	3.03	3	IFNG, TLR2, CCL2
regulation of response to external stimulus (GO:0032101)	3.06	3	TIRAP, CCL2, TLR2
innate immune response-activating signal transduction (GO:0002758)	4.45	3	TIRAP, CD209, TLR2
positive regulation of cell activation (GO:0050867)	3.97	3	TIRAP, CCL2, IFNG
establishment of localization in cell (GO:0051649)	2.47	3	SLC11A1, CD209, IFNG
regulation of chemokine production (GO:0032642)	5.54	3	TIRAP, TLR2, IFNG
regulation of establishment of protein localization (GO:0070201)	3.02	3	TLR2, IFNG, CCL2
regulation of T cell activation (GO:0050863)	4.05	3	CD209, CCL2, IFNG
homeostatic process (GO:0042592)	2.61	3	SLC11A1, MC3R, CCL2
regulation of cell-cell adhesion (GO:0022407)	3.79	3	CD209, IFNG, CCL2
regulation of interleukin-12 production (GO:0032655)	5.78	3	TIRAP, IFNG, TLR2
positive regulation of gene expression (GO:0010628)	2.35	3	SLC11A1, TLR2, IFNG
adaptive immune response (GO:0002250)	4.43	3	SLC11A1, CD209, IFNG
regulation of mononuclear cell proliferation (GO:0032944)	4.45	3	TIRAP, CD209, IFNG
inorganic ion homeostasis (GO:0098771)	3.43	3	SLC11A1, MC3R, CCL2
intracellular signal transduction (GO:0035556)	2.39	3	CISH, CD209, CCL2
regulation of protein transport (GO:0051223)	3.12	3	TLR2, IFNG, CCL2
positive regulation of protein transport (GO:0051222)	3.61	3	TLR2, IFNG, CCL2
positive regulation of cellular protein localization (GO:1903829)	3.85	3	IFNG, TLR2, CCL2
regulation of protein localization (GO:0032880)	2.88	3	IFNG, TLR2, CCL2
cellular protein metabolic process (GO:0044267)	1.63	3	CISH, TLR2, CCL2
positive regulation of establishment of protein localization (GO:1904951)	3.49	3	IFNG, TLR2, CCL2
activation of innate immune response (GO:0002218)	4.41	3	TIRAP, CD209, TLR2
regulation of growth (GO:0040008)	3.26	3	CISH, TIRAP, IFNG
negative regulation of multicellular organismal process (GO:0051241)	2.84	3	SLC11A1, CCL2, IFNG
positive regulation of cell migration (GO:0030335)	3.77	3	TIRAP, IFNG, CCL2
intracellular transport (GO:0046907)	2.67	3	SLC11A1, CD209, IFNG
regulation of leukocyte proliferation (GO:0070663)	4.4	3	TIRAP, CD209, IFNG
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	3	SLC11A1, IFNG, TLR2
positive regulation of catalytic activity (GO:0043085)	2.4	3	SLC11A1, CCL2, IFNG
protein modification process (GO:0036211)	1.79	3	CISH, TLR2, CCL2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	3	SLC11A1, IFNG, TLR2
macromolecule localization (GO:0033036)	2.34	3	SLC11A1, TLR2, IFNG
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	3	CISH, MC3R, CCL2
regulation of cell adhesion (GO:0030155)	3.27	3	CD209, IFNG, CCL2
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	3	CD209, IFNG, CCL2
positive regulation of cell proliferation (GO:0008284)	3.01	3	TIRAP, IFNG, CCL2
antigen processing and presentation (GO:0019882)	4.36	3	SLC11A1, CD209, IFNG
single organism cell adhesion (GO:0098602)	3.63	3	SLC11A1, CD209, IFNG
positive regulation of innate immune response (GO:0045089)	4.22	3	TIRAP, CD209, TLR2
response to cytokine (GO:0034097)	3.84	3	SLC11A1, CCL2, IFNG
positive regulation of cellular component movement (GO:0051272)	3.71	3	TIRAP, IFNG, CCL2
cell-cell adhesion (GO:0098609)	3.34	3	SLC11A1, CD209, IFNG
cellular protein modification process (GO:0006464)	1.79	3	CISH, CCL2, TLR2
regulation of vesicle-mediated transport (GO:0060627)	3.63	3	SLC11A1, CCL2, IFNG
establishment of protein localization (GO:0045184)	2.53	3	SLC11A1, TLR2, IFNG
protein transport (GO:0015031)	2.62	3	SLC11A1, TLR2, IFNG
macromolecule modification (GO:0043412)	1.73	3	CISH, CCL2, TLR2
regulation of cellular component movement (GO:0051270)	3.08	3	TIRAP, CCL2, IFNG
leukocyte cell-cell adhesion (GO:0007159)	4.26	3	SLC11A1, CD209, IFNG
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	3	SLC11A1, IFNG, TLR2
metal ion homeostasis (GO:0055065)	3.61	3	SLC11A1, MC3R, CCL2
cation homeostasis (GO:0055080)	3.46	3	SLC11A1, MC3R, CCL2
regulation of cell migration (GO:0030334)	3.23	3	TIRAP, CCL2, IFNG
cellular localization (GO:0051641)	2.32	3	SLC11A1, CD209, IFNG
regulation of cellular protein localization (GO:1903827)	3.43	3	TLR2, IFNG, CCL2
regulation of locomotion (GO:0040012)	3.12	3	TIRAP, IFNG, CCL2
single-multicellular organism process (GO:0044707)	1.78	3	SLC11A1, MC3R, TLR2
positive regulation of locomotion (GO:0040017)	3.71	3	TIRAP, CCL2, IFNG
protein metabolic process (GO:0019538)	1.45	3	CISH, TLR2, CCL2
positive regulation of chemokine production (GO:0032722)	5.82	3	TIRAP, IFNG, TLR2
ion homeostasis (GO:0050801)	3.42	3	SLC11A1, MC3R, CCL2
regulation of lymphocyte proliferation (GO:0050670)	4.46	3	TIRAP, CD209, IFNG
positive regulation of RNA metabolic process (GO:0051254)	2.51	3	SLC11A1, TLR2, IFNG
regulation of interleukin-6 production (GO:0032675)	5.08	3	TIRAP, TLR2, IFNG
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	3	SLC11A1, IFNG, TLR2
positive regulation of lymphocyte activation (GO:0051251)	4.07	3	TIRAP, IFNG, CCL2
positive regulation of leukocyte activation (GO:0002696)	4.0	3	TIRAP, CCL2, IFNG
regulation of cell motility (GO:2000145)	3.16	3	TIRAP, CCL2, IFNG
negative regulation of cellular process (GO:0048523)	1.41	3	CISH, CCL2, IFNG
positive regulation of cell motility (GO:2000147)	3.74	3	TIRAP, IFNG, CCL2
positive regulation of interleukin-12 production (GO:0032735)	6.23	3	TIRAP, TLR2, IFNG
chemical homeostasis (GO:0048878)	2.97	3	SLC11A1, MC3R, CCL2
positive regulation of interleukin-6 production (GO:0032755)	5.51	3	TIRAP, IFNG, TLR2
regulation of intracellular protein transport (GO:0033157)	3.8	2	TLR2, CCL2
regulation of cytokine secretion (GO:0050707)	4.74	2	TLR2, IFNG
positive regulation of intracellular transport (GO:0032388)	4.08	2	CCL2, TLR2
regulation of secretion (GO:0051046)	3.2	2	IFNG, TLR2
response to bacterial lipopeptide (GO:0070339)	7.94	2	TIRAP, TLR2
regulation of cytokine biosynthetic process (GO:0042035)	5.15	2	TIRAP, IFNG
positive regulation of chemotaxis (GO:0050921)	4.94	2	TIRAP, CCL2
cell chemotaxis (GO:0060326)	4.63	2	CCL2, IFNG
regulation of cell killing (GO:0031341)	5.6	2	IFNG, CCL2
positive regulation of cell killing (GO:0031343)	6.09	2	CCL2, IFNG
single-organism metabolic process (GO:0044710)	1.63	2	SLC11A1, CCL2
positive regulation of inflammatory response (GO:0050729)	4.98	2	CCL2, TLR2
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	CISH, IFNG
taxis (GO:0042330)	4.03	2	CCL2, IFNG
positive regulation of cell adhesion (GO:0045785)	3.79	2	CCL2, IFNG
cellular developmental process (GO:0048869)	1.82	2	TIRAP, IFNG
cell activation involved in immune response (GO:0002263)	4.86	2	SLC11A1, IFNG
regulation of inflammatory response (GO:0050727)	4.03	2	CCL2, TLR2
leukocyte activation involved in immune response (GO:0002366)	4.88	2	SLC11A1, IFNG
negative regulation of response to stimulus (GO:0048585)	2.52	2	CISH, CCL2
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122)	4.27	2	TIRAP, TLR2
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123)	4.54	2	TIRAP, TLR2
cellular homeostasis (GO:0019725)	3.23	2	SLC11A1, CCL2
leukocyte chemotaxis (GO:0030595)	4.96	2	CCL2, IFNG
neutrophil chemotaxis (GO:0030593)	5.59	2	IFNG, CCL2
chemotaxis (GO:0006935)	4.04	2	IFNG, CCL2
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824)	5.48	2	SLC11A1, IFNG
regulation of protein kinase activity (GO:0045859)	3.15	2	SLC11A1, CISH
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822)	4.99	2	SLC11A1, IFNG
regulation of T cell proliferation (GO:0042129)	4.74	2	CD209, IFNG
positive regulation of adaptive immune response (GO:0002821)	5.42	2	SLC11A1, IFNG
defense response to Gram-positive bacterium (GO:0050830)	5.54	2	TIRAP, TLR2
lymphocyte activation (GO:0046649)	3.96	2	SLC11A1, IFNG
modulation of synaptic transmission (GO:0050804)	4.09	2	IFNG, CCL2
negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	6.96	2	TIRAP, IFNG
modulation of growth of symbiont involved in interaction with host (GO:0044144)	6.9	2	TIRAP, IFNG
positive regulation of interleukin-6 biosynthetic process (GO:0045410)	7.65	2	TIRAP, IFNG
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	CD209, IFNG
vesicle-mediated transport (GO:0016192)	2.72	2	SLC11A1, CD209
endoplasmic reticulum unfolded protein response (GO:0030968)	5.07	2	IFNG, CCL2
cell motility (GO:0048870)	3.02	2	CCL2, IFNG
lipopolysaccharide-mediated signaling pathway (GO:0031663)	6.26	2	TLR2, CCL2
multicellular organismal homeostasis (GO:0048871)	5.07	2	SLC11A1, MC3R
cellular response to stress (GO:0033554)	2.51	2	IFNG, CCL2
regulation of chemotaxis (GO:0050920)	4.53	2	TIRAP, CCL2
regulation of secretion by cell (GO:1903530)	3.28	2	TLR2, IFNG
negative regulation of metabolic process (GO:0009892)	1.93	2	CISH, IFNG
response to virus (GO:0009615)	4.21	2	IFNGR1, IFNG
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	IFNG, CCL2
regulation of multi-organism process (GO:0043900)	3.6	2	TIRAP, IFNG
regulation of interferon-beta production (GO:0032648)	5.92	2	TIRAP, TLR2
movement of cell or subcellular component (GO:0006928)	2.61	2	IFNG, CCL2
leukocyte activation (GO:0045321)	3.76	2	SLC11A1, IFNG
positive regulation of mononuclear cell proliferation (GO:0032946)	4.84	2	TIRAP, IFNG
regulation of apoptotic process (GO:0042981)	2.5	2	CCL2, IFNG
negative regulation of growth of symbiont in host (GO:0044130)	7.02	2	TIRAP, IFNG
response to bacterial lipoprotein (GO:0032493)	7.78	2	TIRAP, TLR2
response to protozoan (GO:0001562)	6.73	2	SLC11A1, IFNG
organic substance biosynthetic process (GO:1901576)	1.34	2	SLC11A1, SP110
T cell activation involved in immune response (GO:0002286)	5.76	2	SLC11A1, IFNG
positive regulation of hydrolase activity (GO:0051345)	2.91	2	IFNG, CCL2
lymphocyte activation involved in immune response (GO:0002285)	5.22	2	SLC11A1, IFNG
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	CD209, IFNG
intracellular protein transport (GO:0006886)	3.2	2	SLC11A1, IFNG
regulation of kinase activity (GO:0043549)	3.07	2	SLC11A1, CISH
positive regulation of leukocyte migration (GO:0002687)	5.05	2	TIRAP, CCL2
regulation of leukocyte migration (GO:0002685)	4.72	2	TIRAP, CCL2
immune effector process (GO:0002252)	3.58	2	SLC11A1, IFNG
cell migration (GO:0016477)	3.12	2	CCL2, IFNG
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)	4.6	2	MC3R, CCL2
regulation of leukocyte chemotaxis (GO:0002688)	5.17	2	TIRAP, CCL2
regulation of developmental process (GO:0050793)	2.1	2	CCL2, IFNG
regulation of heart contraction (GO:0008016)	4.35	2	MC3R, IFNG
cellular response to organic substance (GO:0071310)	2.78	2	IFNG, CCL2
positive regulation of MAPK cascade (GO:0043410)	3.57	2	TIRAP, CCL2
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903)	3.82	2	TIRAP, IFNG
cell activation (GO:0001775)	3.47	2	SLC11A1, IFNG
negative regulation of multi-organism process (GO:0043901)	4.7	2	TIRAP, IFNG
regulation of blood circulation (GO:1903522)	4.05	2	MC3R, IFNG
mRNA stabilization (GO:0048255)	6.29	2	SLC11A1, TIRAP
regulation of growth of symbiont in host (GO:0044126)	6.96	2	TIRAP, IFNG
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	SLC11A1, CCL2
regulation of hydrolase activity (GO:0051336)	2.53	2	IFNG, CCL2
MyD88-dependent toll-like receptor signaling pathway (GO:0002755)	6.2	2	TIRAP, TLR2
endocytosis (GO:0006897)	3.69	2	SLC11A1, CD209
RNA stabilization (GO:0043489)	6.26	2	SLC11A1, TIRAP
programmed cell death (GO:0012501)	3.1	2	TLR2, IFNG
cellular response to cytokine stimulus (GO:0071345)	4.33	2	CCL2, IFNG
regulation of response to interferon-gamma (GO:0060330)	6.64	2	IFNGR1, IFNG
regulation of transferase activity (GO:0051338)	2.88	2	SLC11A1, CISH
regulation of immune effector process (GO:0002697)	3.71	2	CCL2, IFNG
positive regulation of leukocyte chemotaxis (GO:0002690)	5.35	2	TIRAP, CCL2
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	SLC11A1, TIRAP
regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	6.78	2	CCL2, TLR2
defense response to protozoan (GO:0042832)	6.84	2	SLC11A1, IFNG
positive regulation of immune effector process (GO:0002699)	4.69	2	IFNG, CCL2
phosphorylation (GO:0016310)	2.63	2	TLR2, CCL2
cell differentiation (GO:0030154)	2.14	2	TIRAP, IFNG
positive regulation of synaptic transmission (GO:0050806)	5.07	2	IFNG, CCL2
regulation of adaptive immune response (GO:0002819)	4.91	2	SLC11A1, IFNG
response to wounding (GO:0009611)	4.39	2	SLC11A1, CCL2
regulation of response to cytokine stimulus (GO:0060759)	4.77	2	IFNGR1, IFNG
regulation of protein targeting (GO:1903533)	4.0	2	TLR2, CCL2
cellular response to lipopolysaccharide (GO:0071222)	4.94	2	IFNG, CCL2
regulation of MAPK cascade (GO:0043408)	3.22	2	TIRAP, CCL2
positive regulation of phagocytosis (GO:0050766)	5.9	2	SLC11A1, CCL2
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	SLC11A1, CCL2
regulation of phagocytosis (GO:0050764)	5.49	2	SLC11A1, CCL2
leukocyte aggregation (GO:0070486)	4.41	2	SLC11A1, IFNG
lymphocyte aggregation (GO:0071593)	4.44	2	SLC11A1, IFNG
regulation of system process (GO:0044057)	3.53	2	MC3R, IFNG
regulation of mRNA stability (GO:0043488)	4.81	2	SLC11A1, TIRAP
regulation of RNA stability (GO:0043487)	4.78	2	SLC11A1, TIRAP
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	IFNG, CCL2
granulocyte migration (GO:0097530)	5.41	2	IFNG, CCL2
toll-like receptor signaling pathway (GO:0002224)	5.26	2	TIRAP, TLR2
pattern recognition receptor signaling pathway (GO:0002221)	5.02	2	TIRAP, TLR2
regulation of interleukin-8 production (GO:0032677)	5.62	2	TIRAP, TLR2
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	CISH, IFNG
cellular metal ion homeostasis (GO:0006875)	3.75	2	SLC11A1, CCL2
cellular response to lipid (GO:0071396)	3.96	2	IFNG, CCL2
positive regulation of toll-like receptor signaling pathway (GO:0034123)	6.78	2	TIRAP, TLR2
cellular ion homeostasis (GO:0006873)	3.57	2	SLC11A1, CCL2
positive regulation of B cell activation (GO:0050871)	5.27	2	TIRAP, IFNG
biosynthetic process (GO:0009058)	1.32	2	SLC11A1, SP110
regulation of intracellular transport (GO:0032386)	3.58	2	CCL2, TLR2
cellular cation homeostasis (GO:0030003)	3.6	2	SLC11A1, CCL2
cellular chemical homeostasis (GO:0055082)	3.4	2	SLC11A1, CCL2
negative regulation of developmental process (GO:0051093)	3.17	2	CCL2, IFNG
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	TIRAP, TLR2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	TIRAP, TLR2
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	TIRAP, TLR2
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	CCL2, IFNG
regulation of cytokine-mediated signaling pathway (GO:0001959)	4.82	2	IFNGR1, IFNG
response to drug (GO:0042493)	3.71	2	IFNG, CCL2
positive regulation of lymphocyte proliferation (GO:0050671)	4.85	2	TIRAP, IFNG
cytokine production (GO:0001816)	5.42	2	SLC11A1, TLR2
positive regulation of T cell activation (GO:0050870)	4.39	2	IFNG, CCL2
regulation of type I interferon production (GO:0032479)	5.03	2	TIRAP, TLR2
regulation of STAT cascade (GO:1904892)	4.78	2	CISH, IFNG
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	2	TIRAP, CCL2
myeloid leukocyte migration (GO:0097529)	5.13	2	CCL2, IFNG
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	2	TIRAP, CCL2
negative regulation of cytokine production (GO:0001818)	4.4	2	SLC11A1, IFNG
response to endoplasmic reticulum stress (GO:0034976)	4.46	2	CCL2, IFNG
negative regulation of growth (GO:0045926)	4.24	2	TIRAP, IFNG
cellular response to lipoteichoic acid (GO:0071223)	7.53	2	TIRAP, TLR2
cellular response to bacterial lipoprotein (GO:0071220)	7.94	2	TIRAP, TLR2
cellular response to bacterial lipopeptide (GO:0071221)	7.94	2	TIRAP, TLR2
regulation of B cell activation (GO:0050864)	4.92	2	TIRAP, IFNG
neutrophil migration (GO:1990266)	5.52	2	IFNG, CCL2
T cell activation (GO:0042110)	4.45	2	SLC11A1, IFNG
leukocyte migration (GO:0050900)	4.19	2	IFNG, CCL2
humoral immune response (GO:0006959)	4.59	2	CCL2, IFNG
regulation of interleukin-6 biosynthetic process (GO:0045408)	6.96	2	TIRAP, IFNG
cell death (GO:0008219)	3.05	2	TLR2, IFNG
regulation of cell death (GO:0010941)	2.43	2	IFNG, CCL2
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	IFNG, CCL2
protein import into nucleus, translocation (GO:0000060)	6.36	2	SLC11A1, IFNG
nitrogen compound transport (GO:0071705)	3.54	2	SLC11A1, CD209
viral genome replication (GO:0019079)	6.73	2	CD209, CCL2
regulation of programmed cell death (GO:0043067)	2.49	2	CCL2, IFNG
positive regulation of leukocyte proliferation (GO:0070665)	4.79	2	TIRAP, IFNG
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	7.09	2	TLR2, CCL2
regulation of granulocyte chemotaxis (GO:0071622)	6.07	2	TIRAP, CCL2
granulocyte chemotaxis (GO:0071621)	5.48	2	CCL2, IFNG
protein phosphorylation (GO:0006468)	2.89	2	CCL2, TLR2
positive regulation of cytokine biosynthetic process (GO:0042108)	5.65	2	TIRAP, IFNG
regulation of JAK-STAT cascade (GO:0046425)	4.78	2	CISH, IFNG
apoptotic process (GO:0006915)	3.14	2	TLR2, IFNG
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	TLR2, CCL2
response to interferon-gamma (GO:0034341)	5.4	2	SLC11A1, CCL2
interferon-gamma-mediated signaling pathway (GO:0060333)	5.48	2	IFNGR1, IFNG
single-organism transport (GO:0044765)	2.18	2	SLC11A1, TLR2
macromolecule biosynthetic process (GO:0009059)	1.61	2	SLC11A1, SP110
T cell aggregation (GO:0070489)	4.45	2	SLC11A1, IFNG
monovalent inorganic cation homeostasis (GO:0055067)	4.93	2	SLC11A1, MC3R
regulation of interferon-gamma-mediated signaling pathway (GO:0060334)	6.68	2	IFNGR1, IFNG
regulation of protein secretion (GO:0050708)	3.77	2	IFNG, TLR2
regulation of toll-like receptor signaling pathway (GO:0034121)	5.88	2	TIRAP, TLR2
regulation of endocytosis (GO:0030100)	4.42	2	SLC11A1, CCL2
single-organism localization (GO:1902578)	2.09	2	SLC11A1, TLR2
locomotion (GO:0040011)	2.91	2	IFNG, CCL2
response to lipoteichoic acid (GO:0070391)	7.53	2	TIRAP, TLR2
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	CCL2, TLR2
regulation of multicellular organismal development (GO:2000026)	2.31	2	IFNG, CCL2
phosphorus metabolic process (GO:0006793)	2.15	2	CCL2, TLR2
positive regulation of endocytosis (GO:0045807)	4.98	2	SLC11A1, CCL2
positive regulation of interleukin-8 production (GO:0032757)	5.92	2	TIRAP, TLR2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cell activation involved in immune response (GO:0002263)	-	4.86	0.035	SLC11A1, IFNG, TLR2
cellular response to lipopolysaccharide (GO:0071222)	-	4.94	0.033	TLR2, IFNG, CCL2
cellular response to lipoteichoic acid (GO:0071223)	-	7.53	0.024	TIRAP, TLR2
cellular response to bacterial lipoprotein (GO:0071220)	-	7.94	0.003	TIRAP, TLR2
regulation of chemokine production (GO:0032642)	-	5.54	0.002	TIRAP, TLR2, IFNG, CCL2
macrophage activation (GO:0042116)	NEW	6.29	0.013	SLC11A1, TIRAP, TLR2
response to bacterial lipopeptide (GO:0070339)	-	7.94	0.003	TIRAP, TLR2
regulation of cytokine biosynthetic process (GO:0042035)	-	5.15	0.02	TIRAP, TLR2, IFNG
defense response to bacterium (GO:0042742)	-	4.31	0.003	SLC11A1, TIRAP, TLR2, IFNG
regulation of mononuclear cell proliferation (GO:0032944)	-	4.45	0.017	CD209, TIRAP, TLR2, IFNG, CCL2
interspecies interaction between organisms (GO:0044419)	-	3.08	0.041	SLC11A1, SP110, CD209, TLR2, CCL2
response to lipopolysaccharide (GO:0032496)	-	4.03	0.0	SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	-	7.09	0.018	CCL2, TLR2
response to bacterial lipoprotein (GO:0032493)	-	7.78	0.024	TIRAP, TLR2
response to protozoan (GO:0001562)	-	6.73	0.002	SLC11A1, IFNG, TLR2
cytokine production (GO:0001816)	-	5.42	0.006	SLC11A1, TIRAP, IFNG, TLR2
regulation of lymphocyte activation (GO:0051249)	-	3.73	0.041	TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
response to lipoteichoic acid (GO:0070391)	-	7.53	0.024	TIRAP, TLR2
response to external biotic stimulus (GO:0043207)	-	3.13	0.001	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of cytokine production (GO:0001817)	-	3.4	0.005	SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to cytokine (GO:0034097)	-	3.84	0.038	CISH, TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
response to lipid (GO:0033993)	-	3.11	0.026	SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to bacterium (GO:0009617)	-	4.18	0.0	SLC11A1, TIRAP, TLR2, IFNG, CCL2
JAK-STAT cascade (GO:0007259)	NEW	5.99	0.029	CISH, IFNG, CCL2
negative regulation of interleukin-17 production (GO:0032700)	NEW	7.33	0.015	TLR2, IFNG
positive regulation of leukocyte migration (GO:0002687)	-	5.05	0.013	TIRAP, IFNG, TLR2, CCL2
regulation of leukocyte proliferation (GO:0070663)	-	4.4	0.019	CD209, TIRAP, TLR2, IFNG, CCL2
leukocyte activation involved in immune response (GO:0002366)	-	4.88	0.035	SLC11A1, TLR2, IFNG
regulation of immune system process (GO:0002682)	-	2.5	0.003	TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
negative regulation of growth of symbiont in host (GO:0044130)	-	7.02	0.0	TIRAP, IFNG, TLR2
cellular response to molecule of bacterial origin (GO:0071219)	-	4.88	0.038	IFNG, TIRAP, TLR2, CCL2
regulation of granulocyte chemotaxis (GO:0071622)	-	6.07	0.02	TIRAP, TLR2, CCL2
cellular response to biotic stimulus (GO:0071216)	-	4.76	0.001	IFNG, TIRAP, TLR2, CCL2
multi-organism process (GO:0051704)	-	2.65	0.0	TIRAP, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
regulation of interleukin-6 production (GO:0032675)	-	5.08	0.021	TIRAP, TLR2, IFNG, CCL2
regulation of leukocyte migration (GO:0002685)	-	4.72	0.031	TIRAP, CCL2, TLR2
positive regulation of phagocytosis (GO:0050766)	-	5.9	0.05	SLC11A1, CCL2, IFNG
positive regulation of tumor necrosis factor production (GO:0032760)	-	5.7	0.037	TIRAP, IFNG, TLR2
regulation of interleukin-12 production (GO:0032655)	-	5.78	0.002	TIRAP, IFNG, TLR2
cellular response to bacterial lipopeptide (GO:0071221)	-	7.94	0.008	TIRAP, TLR2
regulation of innate immune response (GO:0045088)	-	3.86	0.011	IFNGR1, TIRAP, IFNG, TLR2
viral genome replication (GO:0019079)	-	6.73	0.05	CD209, CCL2
positive regulation of cytokine biosynthetic process (GO:0042108)	-	5.65	0.005	TIRAP, TLR2, IFNG
positive regulation of chemokine biosynthetic process (GO:0045080)	NEW	7.43	0.048	IFNG, TLR2
response to interferon-gamma (GO:0034341)	-	5.4	0.002	SLC11A1, IFNGR1, TLR2, IFNG, CCL2
defense response (GO:0006952)	-	2.78	0.002	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
negative regulation of multi-organism process (GO:0043901)	-	4.7	0.032	TIRAP, TLR2, IFNG, CCL2
defense response to other organism (GO:0098542)	-	3.75	0.03	SLC11A1, TIRAP, IFNG, TLR2
inflammatory response (GO:0006954)	-	3.64	0.001	SLC11A1, IRGM, TIRAP, TLR2, CCL2
immune response (GO:0006955)	-	2.86	0.001	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
production of molecular mediator of immune response (GO:0002440)	NEW	6.4	0.004	SLC11A1, TLR2, IFNG
interaction with host (GO:0051701)	NEW	4.86	0.019	SLC11A1, CD209, TLR2
regulation of growth of symbiont in host (GO:0044126)	-	6.96	0.0	TIRAP, IFNG, TLR2
response to other organism (GO:0051707)	-	3.48	0.0	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	-	6.96	0.0	TIRAP, IFNG, TLR2
modulation of growth of symbiont involved in interaction with host (GO:0044144)	-	6.9	0.0	TIRAP, IFNG, TLR2
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	-	4.85	0.032	TIRAP, IFNG, TLR2, CCL2
positive regulation of interleukin-6 biosynthetic process (GO:0045410)	-	7.65	0.0	TIRAP, TLR2, IFNG
response to biotic stimulus (GO:0009607)	-	3.09	0.001	TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
positive regulation of toll-like receptor signaling pathway (GO:0034123)	-	6.78	0.03	TIRAP, TLR2
response to stimulus (GO:0050896)	-	1.22	0.034	IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
myeloid leukocyte activation (GO:0002274)	NEW	5.15	0.021	SLC11A1, TIRAP, IFNG, TLR2
regulation of lymphocyte proliferation (GO:0050670)	-	4.46	0.017	CD209, TIRAP, TLR2, IFNG, CCL2
immune system process (GO:0002376)	-	2.29	0.027	IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of tumor necrosis factor production (GO:0032680)	-	5.13	0.025	IFNG, TIRAP, TLR2, CCL2
response to molecule of bacterial origin (GO:0002237)	-	3.99	0.0	SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of interleukin-6 biosynthetic process (GO:0045408)	-	6.96	0.005	TIRAP, IFNG, TLR2
positive regulation of interleukin-12 production (GO:0032735)	-	6.23	0.0	TIRAP, TLR2, IFNG
regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	-	6.78	0.034	CCL2, TLR2
positive regulation of macrophage chemotaxis (GO:0010759)	NEW	7.33	0.035	CCL2, TLR2
defense response to protozoan (GO:0042832)	-	6.84	0.001	SLC11A1, TLR2, IFNG
positive regulation of cytokine production (GO:0001819)	-	3.82	0.014	SLC11A1, TIRAP, IFNG, TLR2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	11	IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
intracellular part (GO:0044424)	0.28	8	IRGM, TIRAP, CISH, CD209, CCL2, SLC11A1, SP110, TLR2
membrane part (GO:0044425)	0.95	8	IFNGR1, TIRAP, CD209, IFNG, SLC11A1, IRGM, MC3R, TLR2
membrane (GO:0016020)	0.68	8	IFNGR1, TIRAP, CISH, CD209, IRGM, SLC11A1, MC3R, TLR2
plasma membrane (GO:0005886)	1.39	8	MC3R, TIRAP, CISH, CD209, IRGM, SLC11A1, IFNGR1, TLR2
plasma membrane part (GO:0044459)	1.95	7	MC3R, TIRAP, IFNG, SLC11A1, IRGM, IFNGR1, TLR2
membrane-bounded organelle (GO:0043227)	0.47	7	IRGM, TIRAP, CD209, SP110, SLC11A1, CCL2, TLR2
organelle (GO:0043226)	0.4	7	IRGM, TIRAP, CD209, SP110, SLC11A1, CCL2, TLR2
cytoplasmic part (GO:0044444)	0.82	6	CISH, TIRAP, IRGM, SLC11A1, CCL2, TLR2
intracellular organelle (GO:0043229)	0.51	6	TIRAP, IRGM, SLC11A1, SP110, CCL2, TLR2
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	TIRAP, IRGM, SLC11A1, SP110, CCL2, TLR2
cytoplasm (GO:0005737)	1.01	5	TIRAP, CISH, CD209, CCL2, TLR2
vesicle (GO:0031982)	1.64	5	TIRAP, IRGM, CD209, TLR2, CCL2
integral component of membrane (GO:0016021)	1.14	5	SLC11A1, IFNGR1, CD209, MC3R, TLR2
intracellular organelle part (GO:0044446)	0.81	5	SLC11A1, IRGM, TIRAP, TLR2, SP110
intrinsic component of membrane (GO:0031224)	1.13	5	SLC11A1, IFNGR1, CD209, MC3R, TLR2
organelle part (GO:0044422)	0.79	5	SLC11A1, IRGM, TIRAP, SP110, TLR2
cytoplasmic vesicle (GO:0031410)	2.87	4	IRGM, TIRAP, CCL2, TLR2
intrinsic component of plasma membrane (GO:0031226)	2.53	4	SLC11A1, IFNGR1, MC3R, TLR2
extracellular region part (GO:0044421)	1.57	4	TIRAP, CD209, IFNG, CCL2
integral component of plasma membrane (GO:0005887)	2.57	4	SLC11A1, IFNGR1, MC3R, TLR2
intracellular vesicle (GO:0097708)	2.86	4	IRGM, TIRAP, CCL2, TLR2
endocytic vesicle membrane (GO:0030666)	4.82	3	SLC11A1, IRGM, TLR2
organelle membrane (GO:0031090)	1.97	3	SLC11A1, IRGM, TLR2
phagocytic vesicle membrane (GO:0030670)	5.71	3	SLC11A1, IRGM, TLR2
bounding membrane of organelle (GO:0098588)	2.39	3	SLC11A1, IRGM, TLR2
membrane-bounded vesicle (GO:0031988)	1.71	3	TIRAP, CD209, CCL2
cytoplasmic vesicle part (GO:0044433)	3.41	3	SLC11A1, IRGM, TLR2
cytoplasmic vesicle membrane (GO:0030659)	3.67	3	SLC11A1, IRGM, TLR2
extracellular region (GO:0005576)	2.18	3	CD209, CCL2, IFNG
vesicle membrane (GO:0012506)	3.63	3	SLC11A1, IRGM, TLR2
whole membrane (GO:0098805)	2.85	3	SLC11A1, IRGM, TLR2
Golgi apparatus (GO:0005794)	2.7	2	IRGM, TLR2
extracellular space (GO:0005615)	2.63	2	CCL2, IFNG
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	TIRAP, CCL2
cytosol (GO:0005829)	1.68	2	CISH, TIRAP
cell projection part (GO:0044463)	2.97	2	TIRAP, CCL2
vacuolar membrane (GO:0005774)	3.45	2	SLC11A1, IRGM
endocytic vesicle (GO:0030139)	5.04	2	TIRAP, CCL2
nuclear part (GO:0044428)	1.55	2	TIRAP, SP110
vacuolar part (GO:0044437)	3.26	2	SLC11A1, IRGM
cell projection (GO:0042995)	2.47	2	IRGM, CCL2
cell surface (GO:0009986)	3.44	2	CD209, TLR2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
endocytic vesicle membrane (GO:0030666)	-	4.82	0.013	SLC11A1, IRGM, TLR2, IFNG
plasma membrane part (GO:0044459)	-	1.95	0.006	MC3R, TIRAP, IFNG, SLC11A1, IRGM, IFNGR1, TLR2
integral component of plasma membrane (GO:0005887)	-	2.57	0.01	IFNGR1, CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
phagocytic vesicle membrane (GO:0030670)	-	5.71	0.022	SLC11A1, IRGM, TLR2