Disease table of MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO OMIM ID: 607948

Gene-disease associations table

GeneAssociated with MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CCL2OMIMHGNC link17q123609423, 607948, 182940
SLC11A1OMIMHGNC link2q352607948, 610446
IFNGOMIMHGNC link12q155609135, PS191100, 609532, 607948, 609423
MC3ROMIMHGNC link20q13.22602025, 607948
TIRAPOMIMHGNC link11q24.24611162, PS610799, 607948, 614382
TLR2OMIMHGNC link4q31.33114500, 607948, 246300
CD209OMIMHGNC link19p13.23609423, 607948, 614371
CISHOMIMHGNC link3p21.23614383, 607948, 611162
SP110OMIMHGNC link2q37.12235550, 607948
IRGMOMIMHGNC link5q33.12PS266600, 607948
IFNGR1OMIMHGNC link6q23.35209950, 600263, 615978, 607948, 610424

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
2q32SP110, SLC11A1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2q2SP110, SLC11A1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22SP110, SLC11A1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122CISH, IFNG
STAT1NO79CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML2IFNG, CCL2
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC2IFNG, CCL2
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63TLR2, IFNG, CCL2
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63TLR2, IFNG, CCL2
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC13IFNGR1, TLR2, CCL2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CCL2YES17SP1, XBP1, NFAT5, NFKB1, PREB, HEY1, HDAC2, NFIC, NR1I2, ATF4, JUN, IRF3, RELA, APEX1, MAML1, REL, STAT10
IFNGYES29BCL6, TFAP4, NFATC2, TBX21, EGR1, NFKB1, CREB1, STAT5A, NFATC1, JUN, GATA1, ATF2, RELA, PARP1, GATA3, EP300, STAT1, STAT3, PROX1, RFX5, EOMES, YY1, NFIL3, STAT5B, MSC, MYCN, STAT4, IRF1, USF10
TLR2YES4SP1, NFKB1, HIF1A, RELA0
CISHYES2STAT3, STAT60
IFNGR1YES2SP1, IRF20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CCL2TIRAPNo1PCNA
IFNGIFNGR1Yes1IFNG
TIRAPTLR2Yes4TIRAP, MYD88, IRAK1, TLR2
TIRAPCISHNo1MYD88
TIRAPIFNGR1No1JAK1
TLR2CD209No1CLEC4M
TLR2CISHNo2MYD88, EGFR
TLR2IRGMNo1ATG16L1
CISHIRGMNo1AMBRA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CCL2IFNGNo-8TYK2, IL23A, JUN, JAK2, IL23R, IL12RB1, TGFB1, FOS
CCL2MC3RNo-1PTH
CCL2TIRAPNo-1IL6
CCL2TLR2No-11CSF2, IL4, MMP1, CXCR2, MMP9, MMP2, IL6, SRC, MAPK14, NFKB1, ICAM1
CCL2CD209No-4SRC, TGFB1, IL4, IL10
CCL2CISHNo-4TYK2, FOS, JAK2, TP53
SLC11A1IFNGNo-1IRF1
IFNGTIRAPNo-1EIF2AK2
IFNGTLR2No-3SOCS1, STAT3, RELA
IFNGCD209No-1TGFB1
IFNGCISHNo-15STAT3, STAT5A, IL2, GHR, STAT6, FOS, SOCS3, JAK2, IL2RB, JAK1, PRLR, TYK2, SOCS1, STAT4, EPOR
MC3RTLR2No-1VIP
TIRAPTLR2Yesactivation13HMGB1, IRAK2, IKBKB, TOLLIP, TRAF6, IL6, TLR1, CD14, TLR4, HSPD1, MAP3K7, CHUK, LY96
TIRAPCISHNo-0
TLR2CD209No-2SRC, IL4
TLR2CISHNo-2STAT3, SOCS1
CD209CISHNo-1LCK

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
IFNGIFNGR1Yes2IFNGR1, IFNG

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Tuberculosishsa051525.175TIRAP, IFNGR1, CD209, TLR2, IFNG
Chagas disease (American trypanosomiasis)hsa051425.994IFNGR1, TLR2, IFNG, CCL2
Herpes simplex infectionhsa051685.084IFNGR1, IFNG, TLR2, CCL2
Measleshsa051625.64IFNGR1, CD209, TLR2, IFNG
Toxoplasmosishsa051455.714IFNGR1, IRGM, IFNG, TLR2
Rheumatoid arthritishsa053236.053IFNG, TLR2, CCL2
Inflammatory bowel disease (IBD)hsa053216.433IFNGR1, IFNG, TLR2
Jak-STAT signaling pathwayhsa046305.443CISH, IFNGR1, IFNG
Leishmaniasishsa051406.323IFNGR1, IFNG, TLR2
Malariahsa051447.153IFNG, TLR2, CCL2
Influenza Ahsa051645.213IFNGR1, CCL2, IFNG
Cytokine-cytokine receptor interactionhsa040604.673IFNGR1, CCL2, IFNG
Salmonella infectionhsa051326.292IFNGR1, IFNG
Natural killer cell mediated cytotoxicityhsa046505.532IFNGR1, IFNG
Toll-like receptor signaling pathwayhsa046206.02TIRAP, TLR2
Phagosomehsa041455.272CD209, TLR2
Osteoclast differentiationhsa043805.642IFNGR1, IFNG
HIF-1 signaling pathwayhsa040665.92IFNGR1, IFNG
Amoebiasishsa051465.822IFNG, TLR2
Hepatitis Bhsa051615.522TIRAP, TLR2

NET-GE enrichment

Term New enriched termICP valueGenes
Immune diseasesNEW4.470.043IFNGR1, IFNG, TLR2, CCL2
Salmonella infection (hsa05132) -6.290.008IFNGR1, TLR2, IFNG, CCL2
Infectious diseases: ParasiticNEW4.460.002TIRAP, IRGM, IFNG, IFNGR1, CCL2, TLR2
Infectious diseases: BacterialNEW3.760.025TIRAP, IFNGR1, CD209, TLR2, IFNG
Rheumatoid arthritis (hsa05323) -6.050.023IFNG, TLR2, CCL2
Infectious diseases: ViralNEW3.290.01TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
Inflammatory bowel disease (IBD) (hsa05321) -6.430.011IFNGR1, IFNG, TLR2
Toll-like receptor signaling pathway (hsa04620) -6.00.007TIRAP, TLR2, IFNG, CCL2
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.01IFNGR1, TLR2, IFNG, CCL2
Leishmaniasis (hsa05140) -6.320.013IFNGR1, IFNG, TLR2
Herpes simplex infection (hsa05168) -5.080.009IFNGR1, IFNG, TLR2, CCL2
Malaria (hsa05144) -7.150.036IFNG, TLR2, CCL2
Tuberculosis (hsa05152) -5.170.013TIRAP, IFNGR1, CD209, TLR2, IFNG
NF-kappa B signaling pathway (hsa04064) NEW6.210.004IFNG, TIRAP, TLR2, CCL2
Toxoplasmosis (hsa05145) -5.710.001IFNGR1, IRGM, TIRAP, IFNG, TLR2
Measles (hsa05162) -5.60.029IFNGR1, CD209, TLR2, IFNG
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.376TIRAP, CISH, CD209, IFNG, IFNGR1, TLR2
Cytokine Signaling in Immune systemR-HSA-12802153.743CISH, IFNGR1, IFNG
Innate Immune SystemR-HSA-1682493.173TIRAP, CD209, TLR2
DiseaseR-HSA-16436853.333SLC11A1, TIRAP, TLR2
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.562TIRAP, TLR2
Regulation of IFNG signalingR-HSA-8773129.182IFNGR1, IFNG
Signaling by GPCRR-HSA-3727902.682MC3R, CCL2
Diseases of Immune SystemR-HSA-52602718.342TIRAP, TLR2
MyD88 deficiency (TLR2/4)R-HSA-56024989.522TIRAP, TLR2
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692MC3R, CCL2
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.512TIRAP, TLR2
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.112TIRAP, TLR2
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.512TIRAP, TLR2
Peptide ligand-binding receptorsR-HSA-3752765.412MC3R, CCL2
Toll-Like Receptors CascadesR-HSA-1688985.912TIRAP, TLR2
Interferon SignalingR-HSA-9135314.952IFNGR1, IFNG
Diseases associated with the TLR signaling cascadeR-HSA-56023588.342TIRAP, TLR2
Interferon gamma signalingR-HSA-8773005.672IFNGR1, IFNG
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.562TIRAP, TLR2
IRAK4 deficiency (TLR2/4)R-HSA-56030419.522TIRAP, TLR2
Activated TLR4 signallingR-HSA-1660546.272TIRAP, TLR2
GPCR ligand bindingR-HSA-5007924.192MC3R, CCL2
Signal TransductionR-HSA-1625821.782MC3R, CCL2

NET-GE enrichment

Term New enriched termICP valueGenes
MyD88 deficiency (TLR2/4) (R-HSA-5602498) -9.520.003TIRAP, TLR2
Regulation of IFNG signaling (R-HSA-877312) -9.180.004IFNGR1, IFNG
Toll-Like Receptors Cascades (R-HSA-168898) -5.910.012TIRAP, TLR2, CCL2, IFNG
IRAK4 deficiency (TLR2/4) (R-HSA-5603041) -9.520.005TIRAP, TLR2
Diseases associated with the TLR signaling cascade (R-HSA-5602358) -8.340.014TIRAP, TLR2
Diseases of Immune System (R-HSA-5260271) -8.340.014TIRAP, TLR2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1811IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
protein binding (GO:0005515) 0.469IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
molecular transducer activity (GO:0060089) 2.324IFNGR1, CD209, MC3R, TLR2
receptor binding (GO:0005102) 2.434TIRAP, TLR2, IFNG, CCL2
receptor activity (GO:0004872) 2.324IFNGR1, CD209, MC3R, TLR2
signal transducer activity (GO:0004871) 2.284IFNGR1, MC3R, SP110, TLR2
signaling receptor activity (GO:0038023) 2.493IFNGR1, MC3R, TLR2
carbohydrate derivative binding (GO:0097367) 2.033IRGM, TLR2, CCL2
amide binding (GO:0033218) 4.143CD209, MC3R, TLR2
transmembrane signaling receptor activity (GO:0004888) 2.573IFNGR1, MC3R, TLR2
peptide binding (GO:0042277) 4.223CD209, MC3R, TLR2
protein dimerization activity (GO:0046983) 2.723SLC11A1, TIRAP, TLR2
transmembrane receptor activity (GO:0099600) 2.533IFNGR1, MC3R, TLR2
cytokine receptor binding (GO:0005126) 4.142IFNG, CCL2
cation binding (GO:0043169) 1.42CD209, SP110
cytokine activity (GO:0005125) 4.342CCL2, IFNG
protein heterodimerization activity (GO:0046982) 3.642TIRAP, TLR2
organic cyclic compound binding (GO:0097159) 1.052IRGM, SP110
lipid binding (GO:0008289) 3.262TIRAP, TLR2
ion binding (GO:0043167) 1.362CD209, SP110
glycosaminoglycan binding (GO:0005539) 4.422TLR2, CCL2
catalytic activity (GO:0003824) 1.052IRGM, CCL2
small molecule binding (GO:0036094) 1.892CD209, IRGM
Toll-like receptor binding (GO:0035325) 7.662TIRAP, TLR2
metal ion binding (GO:0046872) 1.412CD209, SP110
heterocyclic compound binding (GO:1901363) 1.062IRGM, SP110
identical protein binding (GO:0042802) 2.632SLC11A1, TIRAP
protein homodimerization activity (GO:0042803) 3.162SLC11A1, TIRAP

NET-GE enrichment

Term New enriched termICP valueGenes
amide binding (GO:0033218) -4.140.04CD209, MC3R, TLR2
molecular transducer activity (GO:0060089) -2.320.004IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
peptide binding (GO:0042277) -4.220.037CD209, MC3R, TLR2
signal transducer activity (GO:0004871) -2.280.004IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
cytokine receptor activity (GO:0004896) NEW5.240.001CISH, IFNGR1, TLR2, IFNG
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2610IRGM, TIRAP, CISH, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
biological regulation (GO:0065007) 0.3910IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of biological process (GO:0050789) 0.4510IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of cellular process (GO:0050794) 0.510IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
signal transduction (GO:0007165) 1.289IFNGR1, TIRAP, CISH, CD209, IFNG, SP110, CCL2, MC3R, TLR2
regulation of primary metabolic process (GO:0080090) 1.088CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of metabolic process (GO:0019222) 1.028CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of macromolecule metabolic process (GO:0060255) 1.088CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
regulation of cellular metabolic process (GO:0031323) 1.078CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
response to stimulus (GO:0050896) 1.228IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of response to stimulus (GO:0048583) 1.548TIRAP, CISH, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
multi-organism process (GO:0051704) 2.658TIRAP, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
defense response (GO:0006952) 2.787IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of biosynthetic process (GO:0009889) 1.377TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
immune system process (GO:0002376) 2.297IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
response to stress (GO:0006950) 1.87IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of immune system process (GO:0002682) 2.57TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
cell surface receptor signaling pathway (GO:0007166) 2.097TIRAP, CISH, CD209, IFNG, CCL2, IFNGR1, TLR2
immune response (GO:0006955) 2.867IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
positive regulation of biological process (GO:0048518) 1.27CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
single-organism process (GO:0044699) 0.487CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
regulation of phosphate metabolic process (GO:0019220) 2.356CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R
positive regulation of metabolic process (GO:0009893) 1.746TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
positive regulation of biosynthetic process (GO:0009891) 2.296TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
regulation of cellular biosynthetic process (GO:0031326) 1.386TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
positive regulation of cellular metabolic process (GO:0031325) 1.816TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
positive regulation of response to stimulus (GO:0048584) 2.186TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of signaling (GO:0023051) 1.726CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
regulation of cell communication (GO:0010646) 1.736CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
regulation of defense response (GO:0031347) 3.116TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
response to external biotic stimulus (GO:0043207) 3.136TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of signal transduction (GO:0009966) 1.846CISH, TIRAP, IFNG, CCL2, IFNGR1, TLR2
positive regulation of immune system process (GO:0002684) 2.966TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of molecular function (GO:0065009) 1.786CISH, TIRAP, IFNG, SLC11A1, CCL2, TLR2
regulation of biological quality (GO:0065008) 1.686TIRAP, CD209, IFNG, SLC11A1, CCL2, MC3R
regulation of gene expression (GO:0010468) 1.376TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of phosphorus metabolic process (GO:0051174) 2.356CISH, TIRAP, IFNG, SLC11A1, CCL2, MC3R
single-organism cellular process (GO:0044763) 0.656TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of nitrogen compound metabolic process (GO:0051171) 1.366TIRAP, SP110, SLC11A1, IFNG, MC3R, TLR2
regulation of multicellular organismal process (GO:0051239) 1.876TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
response to other organism (GO:0051707) 3.486TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of immune response (GO:0050776) 2.986TIRAP, CD209, IFNG, SLC11A1, IFNGR1, TLR2
response to biotic stimulus (GO:0009607) 3.096TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
response to external stimulus (GO:0009605) 2.556TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of response to stress (GO:0080134) 2.536TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
regulation of macromolecule biosynthetic process (GO:0010556) 1.436TIRAP, SP110, SLC11A1, IFNG, CCL2, TLR2
positive regulation of cellular process (GO:0048522) 1.36TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
metabolic process (GO:0008152) 0.585SLC11A1, CISH, TLR2, SP110, CCL2
positive regulation of cellular biosynthetic process (GO:0031328) 2.35SLC11A1, MC3R, TIRAP, IFNG, TLR2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465SLC11A1, SP110, TIRAP, IFNG, TLR2
regulation of localization (GO:0032879) 1.945SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of macromolecule metabolic process (GO:0010604) 1.815SLC11A1, IFNG, TIRAP, TLR2, CCL2
regulation of cytokine production (GO:0001817) 3.45SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of multicellular organismal process (GO:0051240) 2.495SLC11A1, IFNG, TIRAP, TLR2, CCL2
response to bacterium (GO:0009617) 4.185SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of protein metabolic process (GO:0051246) 1.935SLC11A1, CISH, TIRAP, IFNG, CCL2
interspecies interaction between organisms (GO:0044419) 3.085IFNGR1, IFNG, CD209, CCL2, SP110
organic substance metabolic process (GO:0071704) 0.635SLC11A1, CISH, TLR2, CCL2, SP110
positive regulation of molecular function (GO:0044093) 2.235SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of protein modification process (GO:0031399) 2.325SLC11A1, CISH, TIRAP, IFNG, CCL2
negative regulation of biological process (GO:0048519) 1.335SLC11A1, CISH, TIRAP, CCL2, IFNG
response to oxygen-containing compound (GO:1901700) 2.575SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of innate immune response (GO:0045088) 3.865CD209, IFNGR1, TIRAP, IFNG, TLR2
positive regulation of phosphate metabolic process (GO:0045937) 2.785SLC11A1, MC3R, TIRAP, IFNG, CCL2
regulation of nucleic acid-templated transcription (GO:1903506) 1.555SLC11A1, TIRAP, TLR2, IFNG, SP110
multi-organism cellular process (GO:0044764) 3.145IFNGR1, SP110, CD209, CCL2, IFNG
inflammatory response (GO:0006954) 3.645SLC11A1, IRGM, TIRAP, TLR2, CCL2
regulation of RNA biosynthetic process (GO:2001141) 1.555SLC11A1, SP110, TIRAP, IFNG, TLR2
response to chemical (GO:0042221) 1.985SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of intracellular signal transduction (GO:1902531) 2.315CISH, IFNG, TIRAP, TLR2, CCL2
response to organic substance (GO:0010033) 2.25SLC11A1, TIRAP, TLR2, IFNG, CCL2
regulation of phosphorylation (GO:0042325) 2.55SLC11A1, CISH, TIRAP, CCL2, IFNG
regulation of cellular protein metabolic process (GO:0032268) 1.995SLC11A1, CISH, TIRAP, IFNG, CCL2
regulation of RNA metabolic process (GO:0051252) 1.525SLC11A1, SP110, TIRAP, IFNG, TLR2
positive regulation of immune response (GO:0050778) 3.45SLC11A1, TIRAP, CD209, TLR2, IFNG
macromolecule metabolic process (GO:0043170) 0.835SLC11A1, CISH, SP110, TLR2, CCL2
regulation of transcription, DNA-templated (GO:0006355) 1.565SLC11A1, IFNG, TIRAP, TLR2, SP110
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.395SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to molecule of bacterial origin (GO:0002237) 3.995SLC11A1, TIRAP, IFNG, TLR2, CCL2
viral process (GO:0016032) 3.155IFNGR1, SP110, CD209, CCL2, IFNG
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.155IFNGR1, SP110, CD209, CCL2, IFNG
regulation of protein phosphorylation (GO:0001932) 2.575SLC11A1, CISH, TIRAP, CCL2, IFNG
positive regulation of phosphorus metabolic process (GO:0010562) 2.785SLC11A1, MC3R, TIRAP, CCL2, IFNG
positive regulation of cytokine production (GO:0001819) 3.825SLC11A1, TIRAP, IFNG, TLR2, CCL2
primary metabolic process (GO:0044238) 0.694CISH, TLR2, SP110, CCL2
cytokine-mediated signaling pathway (GO:0019221) 3.64CISH, IFNGR1, IFNG, CCL2
regulation of cell activation (GO:0050865) 3.534TIRAP, CD209, IFNG, CCL2
regulation of transport (GO:0051049) 2.244SLC11A1, TLR2, IFNG, CCL2
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 5.14TIRAP, IFNG, TLR2, CCL2
regulation of cellular component organization (GO:0051128) 2.014SLC11A1, CISH, IFNG, CCL2
positive regulation of defense response (GO:0031349) 3.834TIRAP, CD209, TLR2, CCL2
multicellular organismal process (GO:0032501) 1.454SLC11A1, MC3R, TLR2, IFNG
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) 5.674IFNG, TIRAP, TLR2, CCL2
defense response to bacterium (GO:0042742) 4.314SLC11A1, TIRAP, TLR2, IFNG
cellular response to chemical stimulus (GO:0070887) 2.574IFNG, TIRAP, TLR2, CCL2
response to lipopolysaccharide (GO:0032496) 4.034SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cell communication (GO:0010647) 2.414TIRAP, IFNG, TLR2, CCL2
cellular response to stimulus (GO:0051716) 1.974TIRAP, TLR2, IFNG, CCL2
regulation of lymphocyte activation (GO:0051249) 3.734TIRAP, CD209, IFNG, CCL2
immune response-regulating signaling pathway (GO:0002764) 3.724TIRAP, CD209, TLR2, IFNG
cellular macromolecule metabolic process (GO:0044260) 0.934CISH, SP110, CCL2, TLR2
regulation of tumor necrosis factor production (GO:0032680) 5.134IFNG, TIRAP, TLR2, CCL2
response to lipid (GO:0033993) 3.114SLC11A1, TIRAP, IFNG, CCL2
positive regulation of protein metabolic process (GO:0051247) 2.434SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cellular protein metabolic process (GO:0032270) 2.494SLC11A1, TIRAP, IFNG, CCL2
cellular response to molecule of bacterial origin (GO:0071219) 4.884TIRAP, IFNG, TLR2, CCL2
organic substance transport (GO:0071702) 2.154SLC11A1, CD209, IFNG, TLR2
cellular response to biotic stimulus (GO:0071216) 4.764IFNG, TIRAP, TLR2, CCL2
biological adhesion (GO:0022610) 2.814SLC11A1, CD209, CCL2, IFNG
regulation of cell proliferation (GO:0042127) 2.414TIRAP, CD209, IFNG, CCL2
positive regulation of tumor necrosis factor production (GO:0032760) 5.74IFNG, TIRAP, TLR2, CCL2
transport (GO:0006810) 1.514SLC11A1, CD209, TLR2, IFNG
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354SLC11A1, MC3R, IFNG, TLR2
positive regulation of transport (GO:0051050) 2.94SLC11A1, TLR2, IFNG, CCL2
innate immune response (GO:0045087) 3.554TIRAP, CD209, IRGM, TLR2
regulation of catalytic activity (GO:0050790) 1.974SLC11A1, CISH, CCL2, IFNG
defense response to other organism (GO:0098542) 3.754SLC11A1, TIRAP, IFNG, TLR2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294SLC11A1, MC3R, IFNG, TLR2
cell adhesion (GO:0007155) 2.824SLC11A1, CD209, CCL2, IFNG
positive regulation of intracellular signal transduction (GO:1902533) 2.954IFNG, TIRAP, TLR2, CCL2
establishment of localization (GO:0051234) 1.484SLC11A1, CD209, IFNG, TLR2
localization (GO:0051179) 1.44SLC11A1, CD209, IFNG, TLR2
positive regulation of signaling (GO:0023056) 2.414IFNG, TIRAP, TLR2, CCL2
cellular response to oxygen-containing compound (GO:1901701) 3.224TIRAP, TLR2, IFNG, CCL2
positive regulation of phosphorylation (GO:0042327) 2.94SLC11A1, TIRAP, IFNG, CCL2
immune response-activating signal transduction (GO:0002757) 3.84TIRAP, CD209, IFNG, TLR2
positive regulation of protein modification process (GO:0031401) 2.74SLC11A1, TIRAP, IFNG, CCL2
cellular metabolic process (GO:0044237) 0.694CISH, SP110, TLR2, CCL2
regulation of leukocyte activation (GO:0002694) 3.64TIRAP, CD209, CCL2, IFNG
activation of immune response (GO:0002253) 3.674TIRAP, CD209, TLR2, IFNG
positive regulation of signal transduction (GO:0009967) 2.54IFNG, TIRAP, TLR2, CCL2
positive regulation of protein phosphorylation (GO:0001934) 2.954SLC11A1, TIRAP, IFNG, CCL2
positive regulation of cellular component organization (GO:0051130) 2.683SLC11A1, CCL2, IFNG
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563SLC11A1, IFNG, TLR2
protein localization (GO:0008104) 2.363SLC11A1, IFNG, TLR2
single organismal cell-cell adhesion (GO:0016337) 3.693SLC11A1, CD209, IFNG
positive regulation of response to external stimulus (GO:0032103) 4.173TIRAP, TLR2, CCL2
regulation of cellular localization (GO:0060341) 3.033IFNG, TLR2, CCL2
regulation of response to external stimulus (GO:0032101) 3.063TIRAP, CCL2, TLR2
innate immune response-activating signal transduction (GO:0002758) 4.453TIRAP, CD209, TLR2
positive regulation of cell activation (GO:0050867) 3.973TIRAP, CCL2, IFNG
establishment of localization in cell (GO:0051649) 2.473SLC11A1, CD209, IFNG
regulation of chemokine production (GO:0032642) 5.543TIRAP, TLR2, IFNG
regulation of establishment of protein localization (GO:0070201) 3.023TLR2, IFNG, CCL2
regulation of T cell activation (GO:0050863) 4.053CD209, CCL2, IFNG
homeostatic process (GO:0042592) 2.613SLC11A1, MC3R, CCL2
regulation of cell-cell adhesion (GO:0022407) 3.793CD209, IFNG, CCL2
regulation of interleukin-12 production (GO:0032655) 5.783TIRAP, IFNG, TLR2
positive regulation of gene expression (GO:0010628) 2.353SLC11A1, TLR2, IFNG
adaptive immune response (GO:0002250) 4.433SLC11A1, CD209, IFNG
regulation of mononuclear cell proliferation (GO:0032944) 4.453TIRAP, CD209, IFNG
inorganic ion homeostasis (GO:0098771) 3.433SLC11A1, MC3R, CCL2
intracellular signal transduction (GO:0035556) 2.393CISH, CD209, CCL2
regulation of protein transport (GO:0051223) 3.123TLR2, IFNG, CCL2
positive regulation of protein transport (GO:0051222) 3.613TLR2, IFNG, CCL2
positive regulation of cellular protein localization (GO:1903829) 3.853IFNG, TLR2, CCL2
regulation of protein localization (GO:0032880) 2.883IFNG, TLR2, CCL2
cellular protein metabolic process (GO:0044267) 1.633CISH, TLR2, CCL2
positive regulation of establishment of protein localization (GO:1904951) 3.493IFNG, TLR2, CCL2
activation of innate immune response (GO:0002218) 4.413TIRAP, CD209, TLR2
regulation of growth (GO:0040008) 3.263CISH, TIRAP, IFNG
negative regulation of multicellular organismal process (GO:0051241) 2.843SLC11A1, CCL2, IFNG
positive regulation of cell migration (GO:0030335) 3.773TIRAP, IFNG, CCL2
intracellular transport (GO:0046907) 2.673SLC11A1, CD209, IFNG
regulation of leukocyte proliferation (GO:0070663) 4.43TIRAP, CD209, IFNG
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243SLC11A1, IFNG, TLR2
positive regulation of catalytic activity (GO:0043085) 2.43SLC11A1, CCL2, IFNG
protein modification process (GO:0036211) 1.793CISH, TLR2, CCL2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813SLC11A1, IFNG, TLR2
macromolecule localization (GO:0033036) 2.343SLC11A1, TLR2, IFNG
G-protein coupled receptor signaling pathway (GO:0007186) 2.643CISH, MC3R, CCL2
regulation of cell adhesion (GO:0030155) 3.273CD209, IFNG, CCL2
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013CD209, IFNG, CCL2
positive regulation of cell proliferation (GO:0008284) 3.013TIRAP, IFNG, CCL2
antigen processing and presentation (GO:0019882) 4.363SLC11A1, CD209, IFNG
single organism cell adhesion (GO:0098602) 3.633SLC11A1, CD209, IFNG
positive regulation of innate immune response (GO:0045089) 4.223TIRAP, CD209, TLR2
response to cytokine (GO:0034097) 3.843SLC11A1, CCL2, IFNG
positive regulation of cellular component movement (GO:0051272) 3.713TIRAP, IFNG, CCL2
cell-cell adhesion (GO:0098609) 3.343SLC11A1, CD209, IFNG
cellular protein modification process (GO:0006464) 1.793CISH, CCL2, TLR2
regulation of vesicle-mediated transport (GO:0060627) 3.633SLC11A1, CCL2, IFNG
establishment of protein localization (GO:0045184) 2.533SLC11A1, TLR2, IFNG
protein transport (GO:0015031) 2.623SLC11A1, TLR2, IFNG
macromolecule modification (GO:0043412) 1.733CISH, CCL2, TLR2
regulation of cellular component movement (GO:0051270) 3.083TIRAP, CCL2, IFNG
leukocyte cell-cell adhesion (GO:0007159) 4.263SLC11A1, CD209, IFNG
positive regulation of transcription, DNA-templated (GO:0045893) 2.563SLC11A1, IFNG, TLR2
metal ion homeostasis (GO:0055065) 3.613SLC11A1, MC3R, CCL2
cation homeostasis (GO:0055080) 3.463SLC11A1, MC3R, CCL2
regulation of cell migration (GO:0030334) 3.233TIRAP, CCL2, IFNG
cellular localization (GO:0051641) 2.323SLC11A1, CD209, IFNG
regulation of cellular protein localization (GO:1903827) 3.433TLR2, IFNG, CCL2
regulation of locomotion (GO:0040012) 3.123TIRAP, IFNG, CCL2
single-multicellular organism process (GO:0044707) 1.783SLC11A1, MC3R, TLR2
positive regulation of locomotion (GO:0040017) 3.713TIRAP, CCL2, IFNG
protein metabolic process (GO:0019538) 1.453CISH, TLR2, CCL2
positive regulation of chemokine production (GO:0032722) 5.823TIRAP, IFNG, TLR2
ion homeostasis (GO:0050801) 3.423SLC11A1, MC3R, CCL2
regulation of lymphocyte proliferation (GO:0050670) 4.463TIRAP, CD209, IFNG
positive regulation of RNA metabolic process (GO:0051254) 2.513SLC11A1, TLR2, IFNG
regulation of interleukin-6 production (GO:0032675) 5.083TIRAP, TLR2, IFNG
positive regulation of RNA biosynthetic process (GO:1902680) 2.543SLC11A1, IFNG, TLR2
positive regulation of lymphocyte activation (GO:0051251) 4.073TIRAP, IFNG, CCL2
positive regulation of leukocyte activation (GO:0002696) 4.03TIRAP, CCL2, IFNG
regulation of cell motility (GO:2000145) 3.163TIRAP, CCL2, IFNG
negative regulation of cellular process (GO:0048523) 1.413CISH, CCL2, IFNG
positive regulation of cell motility (GO:2000147) 3.743TIRAP, IFNG, CCL2
positive regulation of interleukin-12 production (GO:0032735) 6.233TIRAP, TLR2, IFNG
chemical homeostasis (GO:0048878) 2.973SLC11A1, MC3R, CCL2
positive regulation of interleukin-6 production (GO:0032755) 5.513TIRAP, IFNG, TLR2
regulation of intracellular protein transport (GO:0033157) 3.82TLR2, CCL2
regulation of cytokine secretion (GO:0050707) 4.742TLR2, IFNG
positive regulation of intracellular transport (GO:0032388) 4.082CCL2, TLR2
regulation of secretion (GO:0051046) 3.22IFNG, TLR2
response to bacterial lipopeptide (GO:0070339) 7.942TIRAP, TLR2
regulation of cytokine biosynthetic process (GO:0042035) 5.152TIRAP, IFNG
positive regulation of chemotaxis (GO:0050921) 4.942TIRAP, CCL2
cell chemotaxis (GO:0060326) 4.632CCL2, IFNG
regulation of cell killing (GO:0031341) 5.62IFNG, CCL2
positive regulation of cell killing (GO:0031343) 6.092CCL2, IFNG
single-organism metabolic process (GO:0044710) 1.632SLC11A1, CCL2
positive regulation of inflammatory response (GO:0050729) 4.982CCL2, TLR2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012CISH, IFNG
taxis (GO:0042330) 4.032CCL2, IFNG
positive regulation of cell adhesion (GO:0045785) 3.792CCL2, IFNG
cellular developmental process (GO:0048869) 1.822TIRAP, IFNG
cell activation involved in immune response (GO:0002263) 4.862SLC11A1, IFNG
regulation of inflammatory response (GO:0050727) 4.032CCL2, TLR2
leukocyte activation involved in immune response (GO:0002366) 4.882SLC11A1, IFNG
negative regulation of response to stimulus (GO:0048585) 2.522CISH, CCL2
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272TIRAP, TLR2
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.542TIRAP, TLR2
cellular homeostasis (GO:0019725) 3.232SLC11A1, CCL2
leukocyte chemotaxis (GO:0030595) 4.962CCL2, IFNG
neutrophil chemotaxis (GO:0030593) 5.592IFNG, CCL2
chemotaxis (GO:0006935) 4.042IFNG, CCL2
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) 5.482SLC11A1, IFNG
regulation of protein kinase activity (GO:0045859) 3.152SLC11A1, CISH
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) 4.992SLC11A1, IFNG
regulation of T cell proliferation (GO:0042129) 4.742CD209, IFNG
positive regulation of adaptive immune response (GO:0002821) 5.422SLC11A1, IFNG
defense response to Gram-positive bacterium (GO:0050830) 5.542TIRAP, TLR2
lymphocyte activation (GO:0046649) 3.962SLC11A1, IFNG
modulation of synaptic transmission (GO:0050804) 4.092IFNG, CCL2
negative regulation of growth of symbiont involved in interaction with host (GO:0044146) 6.962TIRAP, IFNG
modulation of growth of symbiont involved in interaction with host (GO:0044144) 6.92TIRAP, IFNG
positive regulation of interleukin-6 biosynthetic process (GO:0045410) 7.652TIRAP, IFNG
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062CD209, IFNG
vesicle-mediated transport (GO:0016192) 2.722SLC11A1, CD209
endoplasmic reticulum unfolded protein response (GO:0030968) 5.072IFNG, CCL2
cell motility (GO:0048870) 3.022CCL2, IFNG
lipopolysaccharide-mediated signaling pathway (GO:0031663) 6.262TLR2, CCL2
multicellular organismal homeostasis (GO:0048871) 5.072SLC11A1, MC3R
cellular response to stress (GO:0033554) 2.512IFNG, CCL2
regulation of chemotaxis (GO:0050920) 4.532TIRAP, CCL2
regulation of secretion by cell (GO:1903530) 3.282TLR2, IFNG
negative regulation of metabolic process (GO:0009892) 1.932CISH, IFNG
response to virus (GO:0009615) 4.212IFNGR1, IFNG
regulation of anatomical structure morphogenesis (GO:0022603) 2.792IFNG, CCL2
regulation of multi-organism process (GO:0043900) 3.62TIRAP, IFNG
regulation of interferon-beta production (GO:0032648) 5.922TIRAP, TLR2
movement of cell or subcellular component (GO:0006928) 2.612IFNG, CCL2
leukocyte activation (GO:0045321) 3.762SLC11A1, IFNG
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842TIRAP, IFNG
regulation of apoptotic process (GO:0042981) 2.52CCL2, IFNG
negative regulation of growth of symbiont in host (GO:0044130) 7.022TIRAP, IFNG
response to bacterial lipoprotein (GO:0032493) 7.782TIRAP, TLR2
response to protozoan (GO:0001562) 6.732SLC11A1, IFNG
organic substance biosynthetic process (GO:1901576) 1.342SLC11A1, SP110
T cell activation involved in immune response (GO:0002286) 5.762SLC11A1, IFNG
positive regulation of hydrolase activity (GO:0051345) 2.912IFNG, CCL2
lymphocyte activation involved in immune response (GO:0002285) 5.222SLC11A1, IFNG
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962CD209, IFNG
intracellular protein transport (GO:0006886) 3.22SLC11A1, IFNG
regulation of kinase activity (GO:0043549) 3.072SLC11A1, CISH
positive regulation of leukocyte migration (GO:0002687) 5.052TIRAP, CCL2
regulation of leukocyte migration (GO:0002685) 4.722TIRAP, CCL2
immune effector process (GO:0002252) 3.582SLC11A1, IFNG
cell migration (GO:0016477) 3.122CCL2, IFNG
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62MC3R, CCL2
regulation of leukocyte chemotaxis (GO:0002688) 5.172TIRAP, CCL2
regulation of developmental process (GO:0050793) 2.12CCL2, IFNG
regulation of heart contraction (GO:0008016) 4.352MC3R, IFNG
cellular response to organic substance (GO:0071310) 2.782IFNG, CCL2
positive regulation of MAPK cascade (GO:0043410) 3.572TIRAP, CCL2
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822TIRAP, IFNG
cell activation (GO:0001775) 3.472SLC11A1, IFNG
negative regulation of multi-organism process (GO:0043901) 4.72TIRAP, IFNG
regulation of blood circulation (GO:1903522) 4.052MC3R, IFNG
mRNA stabilization (GO:0048255) 6.292SLC11A1, TIRAP
regulation of growth of symbiont in host (GO:0044126) 6.962TIRAP, IFNG
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962SLC11A1, CCL2
regulation of hydrolase activity (GO:0051336) 2.532IFNG, CCL2
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) 6.22TIRAP, TLR2
endocytosis (GO:0006897) 3.692SLC11A1, CD209
RNA stabilization (GO:0043489) 6.262SLC11A1, TIRAP
programmed cell death (GO:0012501) 3.12TLR2, IFNG
cellular response to cytokine stimulus (GO:0071345) 4.332CCL2, IFNG
regulation of response to interferon-gamma (GO:0060330) 6.642IFNGR1, IFNG
regulation of transferase activity (GO:0051338) 2.882SLC11A1, CISH
regulation of immune effector process (GO:0002697) 3.712CCL2, IFNG
positive regulation of leukocyte chemotaxis (GO:0002690) 5.352TIRAP, CCL2
posttranscriptional regulation of gene expression (GO:0010608) 3.642SLC11A1, TIRAP
regulation of nitric-oxide synthase biosynthetic process (GO:0051769) 6.782CCL2, TLR2
defense response to protozoan (GO:0042832) 6.842SLC11A1, IFNG
positive regulation of immune effector process (GO:0002699) 4.692IFNG, CCL2
phosphorylation (GO:0016310) 2.632TLR2, CCL2
cell differentiation (GO:0030154) 2.142TIRAP, IFNG
positive regulation of synaptic transmission (GO:0050806) 5.072IFNG, CCL2
regulation of adaptive immune response (GO:0002819) 4.912SLC11A1, IFNG
response to wounding (GO:0009611) 4.392SLC11A1, CCL2
regulation of response to cytokine stimulus (GO:0060759) 4.772IFNGR1, IFNG
regulation of protein targeting (GO:1903533) 4.02TLR2, CCL2
cellular response to lipopolysaccharide (GO:0071222) 4.942IFNG, CCL2
regulation of MAPK cascade (GO:0043408) 3.222TIRAP, CCL2
positive regulation of phagocytosis (GO:0050766) 5.92SLC11A1, CCL2
divalent inorganic cation homeostasis (GO:0072507) 3.92SLC11A1, CCL2
regulation of phagocytosis (GO:0050764) 5.492SLC11A1, CCL2
leukocyte aggregation (GO:0070486) 4.412SLC11A1, IFNG
lymphocyte aggregation (GO:0071593) 4.442SLC11A1, IFNG
regulation of system process (GO:0044057) 3.532MC3R, IFNG
regulation of mRNA stability (GO:0043488) 4.812SLC11A1, TIRAP
regulation of RNA stability (GO:0043487) 4.782SLC11A1, TIRAP
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.352IFNG, CCL2
granulocyte migration (GO:0097530) 5.412IFNG, CCL2
toll-like receptor signaling pathway (GO:0002224) 5.262TIRAP, TLR2
pattern recognition receptor signaling pathway (GO:0002221) 5.022TIRAP, TLR2
regulation of interleukin-8 production (GO:0032677) 5.622TIRAP, TLR2
negative regulation of cellular metabolic process (GO:0031324) 2.012CISH, IFNG
cellular metal ion homeostasis (GO:0006875) 3.752SLC11A1, CCL2
cellular response to lipid (GO:0071396) 3.962IFNG, CCL2
positive regulation of toll-like receptor signaling pathway (GO:0034123) 6.782TIRAP, TLR2
cellular ion homeostasis (GO:0006873) 3.572SLC11A1, CCL2
positive regulation of B cell activation (GO:0050871) 5.272TIRAP, IFNG
biosynthetic process (GO:0009058) 1.322SLC11A1, SP110
regulation of intracellular transport (GO:0032386) 3.582CCL2, TLR2
cellular cation homeostasis (GO:0030003) 3.62SLC11A1, CCL2
cellular chemical homeostasis (GO:0055082) 3.42SLC11A1, CCL2
negative regulation of developmental process (GO:0051093) 3.172CCL2, IFNG
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852TIRAP, TLR2
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292TIRAP, TLR2
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832TIRAP, TLR2
regulation of epithelial cell proliferation (GO:0050678) 4.062CCL2, IFNG
regulation of cytokine-mediated signaling pathway (GO:0001959) 4.822IFNGR1, IFNG
response to drug (GO:0042493) 3.712IFNG, CCL2
positive regulation of lymphocyte proliferation (GO:0050671) 4.852TIRAP, IFNG
cytokine production (GO:0001816) 5.422SLC11A1, TLR2
positive regulation of T cell activation (GO:0050870) 4.392IFNG, CCL2
regulation of type I interferon production (GO:0032479) 5.032TIRAP, TLR2
regulation of STAT cascade (GO:1904892) 4.782CISH, IFNG
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562TIRAP, CCL2
myeloid leukocyte migration (GO:0097529) 5.132CCL2, IFNG
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232TIRAP, CCL2
negative regulation of cytokine production (GO:0001818) 4.42SLC11A1, IFNG
response to endoplasmic reticulum stress (GO:0034976) 4.462CCL2, IFNG
negative regulation of growth (GO:0045926) 4.242TIRAP, IFNG
cellular response to lipoteichoic acid (GO:0071223) 7.532TIRAP, TLR2
cellular response to bacterial lipoprotein (GO:0071220) 7.942TIRAP, TLR2
cellular response to bacterial lipopeptide (GO:0071221) 7.942TIRAP, TLR2
regulation of B cell activation (GO:0050864) 4.922TIRAP, IFNG
neutrophil migration (GO:1990266) 5.522IFNG, CCL2
T cell activation (GO:0042110) 4.452SLC11A1, IFNG
leukocyte migration (GO:0050900) 4.192IFNG, CCL2
humoral immune response (GO:0006959) 4.592CCL2, IFNG
regulation of interleukin-6 biosynthetic process (GO:0045408) 6.962TIRAP, IFNG
cell death (GO:0008219) 3.052TLR2, IFNG
regulation of cell death (GO:0010941) 2.432IFNG, CCL2
positive regulation of cell-cell adhesion (GO:0022409) 4.232IFNG, CCL2
protein import into nucleus, translocation (GO:0000060) 6.362SLC11A1, IFNG
nitrogen compound transport (GO:0071705) 3.542SLC11A1, CD209
viral genome replication (GO:0019079) 6.732CD209, CCL2
regulation of programmed cell death (GO:0043067) 2.492CCL2, IFNG
positive regulation of leukocyte proliferation (GO:0070665) 4.792TIRAP, IFNG
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) 7.092TLR2, CCL2
regulation of granulocyte chemotaxis (GO:0071622) 6.072TIRAP, CCL2
granulocyte chemotaxis (GO:0071621) 5.482CCL2, IFNG
protein phosphorylation (GO:0006468) 2.892CCL2, TLR2
positive regulation of cytokine biosynthetic process (GO:0042108) 5.652TIRAP, IFNG
regulation of JAK-STAT cascade (GO:0046425) 4.782CISH, IFNG
apoptotic process (GO:0006915) 3.142TLR2, IFNG
positive regulation of intracellular protein transport (GO:0090316) 4.192TLR2, CCL2
response to interferon-gamma (GO:0034341) 5.42SLC11A1, CCL2
interferon-gamma-mediated signaling pathway (GO:0060333) 5.482IFNGR1, IFNG
single-organism transport (GO:0044765) 2.182SLC11A1, TLR2
macromolecule biosynthetic process (GO:0009059) 1.612SLC11A1, SP110
T cell aggregation (GO:0070489) 4.452SLC11A1, IFNG
monovalent inorganic cation homeostasis (GO:0055067) 4.932SLC11A1, MC3R
regulation of interferon-gamma-mediated signaling pathway (GO:0060334) 6.682IFNGR1, IFNG
regulation of protein secretion (GO:0050708) 3.772IFNG, TLR2
regulation of toll-like receptor signaling pathway (GO:0034121) 5.882TIRAP, TLR2
regulation of endocytosis (GO:0030100) 4.422SLC11A1, CCL2
single-organism localization (GO:1902578) 2.092SLC11A1, TLR2
locomotion (GO:0040011) 2.912IFNG, CCL2
response to lipoteichoic acid (GO:0070391) 7.532TIRAP, TLR2
phosphate-containing compound metabolic process (GO:0006796) 2.162CCL2, TLR2
regulation of multicellular organismal development (GO:2000026) 2.312IFNG, CCL2
phosphorus metabolic process (GO:0006793) 2.152CCL2, TLR2
positive regulation of endocytosis (GO:0045807) 4.982SLC11A1, CCL2
positive regulation of interleukin-8 production (GO:0032757) 5.922TIRAP, TLR2

NET-GE enrichment

Term New enriched termICP valueGenes
cell activation involved in immune response (GO:0002263) -4.860.035SLC11A1, IFNG, TLR2
cellular response to lipopolysaccharide (GO:0071222) -4.940.033TLR2, IFNG, CCL2
cellular response to lipoteichoic acid (GO:0071223) -7.530.024TIRAP, TLR2
cellular response to bacterial lipoprotein (GO:0071220) -7.940.003TIRAP, TLR2
regulation of chemokine production (GO:0032642) -5.540.002TIRAP, TLR2, IFNG, CCL2
macrophage activation (GO:0042116) NEW6.290.013SLC11A1, TIRAP, TLR2
response to bacterial lipopeptide (GO:0070339) -7.940.003TIRAP, TLR2
regulation of cytokine biosynthetic process (GO:0042035) -5.150.02TIRAP, TLR2, IFNG
defense response to bacterium (GO:0042742) -4.310.003SLC11A1, TIRAP, TLR2, IFNG
regulation of mononuclear cell proliferation (GO:0032944) -4.450.017CD209, TIRAP, TLR2, IFNG, CCL2
interspecies interaction between organisms (GO:0044419) -3.080.041SLC11A1, SP110, CD209, TLR2, CCL2
response to lipopolysaccharide (GO:0032496) -4.030.0SLC11A1, TIRAP, TLR2, IFNG, CCL2
positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) -7.090.018CCL2, TLR2
response to bacterial lipoprotein (GO:0032493) -7.780.024TIRAP, TLR2
response to protozoan (GO:0001562) -6.730.002SLC11A1, IFNG, TLR2
cytokine production (GO:0001816) -5.420.006SLC11A1, TIRAP, IFNG, TLR2
regulation of lymphocyte activation (GO:0051249) -3.730.041TIRAP, CD209, IFNG, CCL2, IFNGR1, TLR2
response to lipoteichoic acid (GO:0070391) -7.530.024TIRAP, TLR2
response to external biotic stimulus (GO:0043207) -3.130.001TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
regulation of cytokine production (GO:0001817) -3.40.005SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to cytokine (GO:0034097) -3.840.038CISH, TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
response to lipid (GO:0033993) -3.110.026SLC11A1, TIRAP, TLR2, IFNG, CCL2
response to bacterium (GO:0009617) -4.180.0SLC11A1, TIRAP, TLR2, IFNG, CCL2
JAK-STAT cascade (GO:0007259) NEW5.990.029CISH, IFNG, CCL2
negative regulation of interleukin-17 production (GO:0032700) NEW7.330.015TLR2, IFNG
positive regulation of leukocyte migration (GO:0002687) -5.050.013TIRAP, IFNG, TLR2, CCL2
regulation of leukocyte proliferation (GO:0070663) -4.40.019CD209, TIRAP, TLR2, IFNG, CCL2
leukocyte activation involved in immune response (GO:0002366) -4.880.035SLC11A1, TLR2, IFNG
regulation of immune system process (GO:0002682) -2.50.003TIRAP, CD209, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
negative regulation of growth of symbiont in host (GO:0044130) -7.020.0TIRAP, IFNG, TLR2
cellular response to molecule of bacterial origin (GO:0071219) -4.880.038IFNG, TIRAP, TLR2, CCL2
regulation of granulocyte chemotaxis (GO:0071622) -6.070.02TIRAP, TLR2, CCL2
cellular response to biotic stimulus (GO:0071216) -4.760.001IFNG, TIRAP, TLR2, CCL2
multi-organism process (GO:0051704) -2.650.0TIRAP, CD209, IFNG, SLC11A1, SP110, CCL2, IFNGR1, TLR2
regulation of interleukin-6 production (GO:0032675) -5.080.021TIRAP, TLR2, IFNG, CCL2
regulation of leukocyte migration (GO:0002685) -4.720.031TIRAP, CCL2, TLR2
positive regulation of phagocytosis (GO:0050766) -5.90.05SLC11A1, CCL2, IFNG
positive regulation of tumor necrosis factor production (GO:0032760) -5.70.037TIRAP, IFNG, TLR2
regulation of interleukin-12 production (GO:0032655) -5.780.002TIRAP, IFNG, TLR2
cellular response to bacterial lipopeptide (GO:0071221) -7.940.008TIRAP, TLR2
regulation of innate immune response (GO:0045088) -3.860.011IFNGR1, TIRAP, IFNG, TLR2
viral genome replication (GO:0019079) -6.730.05CD209, CCL2
positive regulation of cytokine biosynthetic process (GO:0042108) -5.650.005TIRAP, TLR2, IFNG
positive regulation of chemokine biosynthetic process (GO:0045080) NEW7.430.048IFNG, TLR2
response to interferon-gamma (GO:0034341) -5.40.002SLC11A1, IFNGR1, TLR2, IFNG, CCL2
defense response (GO:0006952) -2.780.002IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
negative regulation of multi-organism process (GO:0043901) -4.70.032TIRAP, TLR2, IFNG, CCL2
defense response to other organism (GO:0098542) -3.750.03SLC11A1, TIRAP, IFNG, TLR2
inflammatory response (GO:0006954) -3.640.001SLC11A1, IRGM, TIRAP, TLR2, CCL2
immune response (GO:0006955) -2.860.001IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
production of molecular mediator of immune response (GO:0002440) NEW6.40.004SLC11A1, TLR2, IFNG
interaction with host (GO:0051701) NEW4.860.019SLC11A1, CD209, TLR2
regulation of growth of symbiont in host (GO:0044126) -6.960.0TIRAP, IFNG, TLR2
response to other organism (GO:0051707) -3.480.0TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
negative regulation of growth of symbiont involved in interaction with host (GO:0044146) -6.960.0TIRAP, IFNG, TLR2
modulation of growth of symbiont involved in interaction with host (GO:0044144) -6.90.0TIRAP, IFNG, TLR2
positive regulation of NF-kappaB transcription factor activity (GO:0051092) -4.850.032TIRAP, IFNG, TLR2, CCL2
positive regulation of interleukin-6 biosynthetic process (GO:0045410) -7.650.0TIRAP, TLR2, IFNG
response to biotic stimulus (GO:0009607) -3.090.001TIRAP, IFNG, SLC11A1, CCL2, IFNGR1, TLR2
positive regulation of toll-like receptor signaling pathway (GO:0034123) -6.780.03TIRAP, TLR2
response to stimulus (GO:0050896) -1.220.034IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
myeloid leukocyte activation (GO:0002274) NEW5.150.021SLC11A1, TIRAP, IFNG, TLR2
regulation of lymphocyte proliferation (GO:0050670) -4.460.017CD209, TIRAP, TLR2, IFNG, CCL2
immune system process (GO:0002376) -2.290.027IRGM, TIRAP, CD209, IFNG, SLC11A1, CCL2, TLR2
regulation of tumor necrosis factor production (GO:0032680) -5.130.025IFNG, TIRAP, TLR2, CCL2
response to molecule of bacterial origin (GO:0002237) -3.990.0SLC11A1, TIRAP, IFNG, TLR2, CCL2
regulation of interleukin-6 biosynthetic process (GO:0045408) -6.960.005TIRAP, IFNG, TLR2
positive regulation of interleukin-12 production (GO:0032735) -6.230.0TIRAP, TLR2, IFNG
regulation of nitric-oxide synthase biosynthetic process (GO:0051769) -6.780.034CCL2, TLR2
positive regulation of macrophage chemotaxis (GO:0010759) NEW7.330.035CCL2, TLR2
defense response to protozoan (GO:0042832) -6.840.001SLC11A1, TLR2, IFNG
positive regulation of cytokine production (GO:0001819) -3.820.014SLC11A1, TIRAP, IFNG, TLR2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1111IRGM, IFNGR1, CD209, CISH, TIRAP, IFNG, SLC11A1, SP110, CCL2, MC3R, TLR2
intracellular part (GO:0044424) 0.288IRGM, TIRAP, CISH, CD209, CCL2, SLC11A1, SP110, TLR2
membrane part (GO:0044425) 0.958IFNGR1, TIRAP, CD209, IFNG, SLC11A1, IRGM, MC3R, TLR2
membrane (GO:0016020) 0.688IFNGR1, TIRAP, CISH, CD209, IRGM, SLC11A1, MC3R, TLR2
plasma membrane (GO:0005886) 1.398MC3R, TIRAP, CISH, CD209, IRGM, SLC11A1, IFNGR1, TLR2
plasma membrane part (GO:0044459) 1.957MC3R, TIRAP, IFNG, SLC11A1, IRGM, IFNGR1, TLR2
membrane-bounded organelle (GO:0043227) 0.477IRGM, TIRAP, CD209, SP110, SLC11A1, CCL2, TLR2
organelle (GO:0043226) 0.47IRGM, TIRAP, CD209, SP110, SLC11A1, CCL2, TLR2
cytoplasmic part (GO:0044444) 0.826CISH, TIRAP, IRGM, SLC11A1, CCL2, TLR2
intracellular organelle (GO:0043229) 0.516TIRAP, IRGM, SLC11A1, SP110, CCL2, TLR2
intracellular membrane-bounded organelle (GO:0043231) 0.66TIRAP, IRGM, SLC11A1, SP110, CCL2, TLR2
cytoplasm (GO:0005737) 1.015TIRAP, CISH, CD209, CCL2, TLR2
vesicle (GO:0031982) 1.645TIRAP, IRGM, CD209, TLR2, CCL2
integral component of membrane (GO:0016021) 1.145SLC11A1, IFNGR1, CD209, MC3R, TLR2
intracellular organelle part (GO:0044446) 0.815SLC11A1, IRGM, TIRAP, TLR2, SP110
intrinsic component of membrane (GO:0031224) 1.135SLC11A1, IFNGR1, CD209, MC3R, TLR2
organelle part (GO:0044422) 0.795SLC11A1, IRGM, TIRAP, SP110, TLR2
cytoplasmic vesicle (GO:0031410) 2.874IRGM, TIRAP, CCL2, TLR2
intrinsic component of plasma membrane (GO:0031226) 2.534SLC11A1, IFNGR1, MC3R, TLR2
extracellular region part (GO:0044421) 1.574TIRAP, CD209, IFNG, CCL2
integral component of plasma membrane (GO:0005887) 2.574SLC11A1, IFNGR1, MC3R, TLR2
intracellular vesicle (GO:0097708) 2.864IRGM, TIRAP, CCL2, TLR2
endocytic vesicle membrane (GO:0030666) 4.823SLC11A1, IRGM, TLR2
organelle membrane (GO:0031090) 1.973SLC11A1, IRGM, TLR2
phagocytic vesicle membrane (GO:0030670) 5.713SLC11A1, IRGM, TLR2
bounding membrane of organelle (GO:0098588) 2.393SLC11A1, IRGM, TLR2
membrane-bounded vesicle (GO:0031988) 1.713TIRAP, CD209, CCL2
cytoplasmic vesicle part (GO:0044433) 3.413SLC11A1, IRGM, TLR2
cytoplasmic vesicle membrane (GO:0030659) 3.673SLC11A1, IRGM, TLR2
extracellular region (GO:0005576) 2.183CD209, CCL2, IFNG
vesicle membrane (GO:0012506) 3.633SLC11A1, IRGM, TLR2
whole membrane (GO:0098805) 2.853SLC11A1, IRGM, TLR2
Golgi apparatus (GO:0005794) 2.72IRGM, TLR2
extracellular space (GO:0005615) 2.632CCL2, IFNG
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122TIRAP, CCL2
cytosol (GO:0005829) 1.682CISH, TIRAP
cell projection part (GO:0044463) 2.972TIRAP, CCL2
vacuolar membrane (GO:0005774) 3.452SLC11A1, IRGM
endocytic vesicle (GO:0030139) 5.042TIRAP, CCL2
nuclear part (GO:0044428) 1.552TIRAP, SP110
vacuolar part (GO:0044437) 3.262SLC11A1, IRGM
cell projection (GO:0042995) 2.472IRGM, CCL2
cell surface (GO:0009986) 3.442CD209, TLR2

NET-GE enrichment

Term New enriched termICP valueGenes
endocytic vesicle membrane (GO:0030666) -4.820.013SLC11A1, IRGM, TLR2, IFNG
plasma membrane part (GO:0044459) -1.950.006MC3R, TIRAP, IFNG, SLC11A1, IRGM, IFNGR1, TLR2
integral component of plasma membrane (GO:0005887) -2.570.01IFNGR1, CD209, TIRAP, IFNG, SLC11A1, CCL2, MC3R, TLR2
phagocytic vesicle membrane (GO:0030670) -5.710.022SLC11A1, IRGM, TLR2