Disease table of PSORIASIS OMIM ID: PS177900

Gene-disease associations table

GeneAssociated with PSORIASIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IL36RNClinVar, OMIM, HUMSAVARHGNC link2q14.11PS177900
HLA-CClinVar, OMIMHGNC link6p21.332609423, PS177900
CARD14ClinVar, OMIM, HUMSAVARHGNC link17q25.32173200, PS177900
IL23ROMIMHGNC link1p31.32PS266600, PS177900
AP1S3ClinVar, OMIM, HUMSAVARHGNC link2q36.11PS177900
TRAF3IP2ClinVar, OMIM, HUMSAVARHGNC link6q212PS114580, PS177900

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2q2AP1S3, IL36RN
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22AP1S3, IL36RN
62TRAF3IP2, HLA-C
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HLA-CYES4CIITA, MYC, HIVEP2, MYCN0
IL23RYES1TBX210
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HLA-CTRAF3IP2No1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.372AP1S3, HLA-C
Adaptive Immune SystemR-HSA-12802183.192AP1S3, HLA-C

NET-GE enrichment

Term New enriched termICP valueGenes
Immune System (R-HSA-168256) -2.370.0AP1S3, HLA-C
Adaptive Immune System (R-HSA-1280218) -3.190.0AP1S3, HLA-C
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
protein binding (GO:0005515) 0.466IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
receptor binding (GO:0005102) 2.433IL23R, IL36RN, TRAF3IP2
cytokine receptor binding (GO:0005126) 4.142IL23R, IL36RN
signaling receptor activity (GO:0038023) 2.492IL23R, HLA-C
growth factor receptor binding (GO:0070851) 4.872IL23R, IL36RN
cytokine binding (GO:0019955) 5.212IL23R, IL36RN
molecular transducer activity (GO:0060089) 2.322IL23R, HLA-C
transmembrane signaling receptor activity (GO:0004888) 2.572IL23R, HLA-C
receptor activity (GO:0004872) 2.322IL23R, HLA-C
signal transducer activity (GO:0004871) 2.282IL23R, HLA-C
transmembrane receptor activity (GO:0099600) 2.532IL23R, HLA-C
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.396IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
regulation of response to stimulus (GO:0048583) 1.546IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
regulation of biological process (GO:0050789) 0.456IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
regulation of cellular process (GO:0050794) 0.56IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
immune system process (GO:0002376) 2.295IL23R, IL36RN, AP1S3, TRAF3IP2, HLA-C
regulation of signal transduction (GO:0009966) 1.844IL23R, IL36RN, CARD14, TRAF3IP2
response to stimulus (GO:0050896) 1.224IL23R, IL36RN, TRAF3IP2, HLA-C
immune response (GO:0006955) 2.864IL23R, IL36RN, TRAF3IP2, HLA-C
regulation of immune system process (GO:0002682) 2.54IL23R, AP1S3, TRAF3IP2, HLA-C
signal transduction (GO:0007165) 1.284IL23R, CARD14, TRAF3IP2, HLA-C
regulation of signaling (GO:0023051) 1.724IL23R, IL36RN, CARD14, TRAF3IP2
regulation of cell communication (GO:0010646) 1.734IL23R, IL36RN, CARD14, TRAF3IP2
regulation of defense response to virus (GO:0050688) 4.533IL23R, AP1S3, TRAF3IP2
regulation of response to external stimulus (GO:0032101) 3.063IL23R, AP1S3, TRAF3IP2
positive regulation of response to stimulus (GO:0048584) 2.183IL23R, CARD14, TRAF3IP2
regulation of response to biotic stimulus (GO:0002831) 4.33IL23R, AP1S3, TRAF3IP2
positive regulation of signaling (GO:0023056) 2.413IL23R, CARD14, TRAF3IP2
cell surface receptor signaling pathway (GO:0007166) 2.093IL23R, CARD14, HLA-C
positive regulation of cell communication (GO:0010647) 2.413IL23R, CARD14, TRAF3IP2
regulation of defense response (GO:0031347) 3.113IL23R, AP1S3, TRAF3IP2
cytokine-mediated signaling pathway (GO:0019221) 3.63IL23R, CARD14, HLA-C
positive regulation of signal transduction (GO:0009967) 2.53IL23R, CARD14, TRAF3IP2
positive regulation of biological process (GO:0048518) 1.23IL23R, CARD14, TRAF3IP2
negative regulation of biological process (GO:0048519) 1.333IL23R, IL36RN, CARD14
regulation of viral process (GO:0050792) 3.893IL23R, AP1S3, TRAF3IP2
innate immune response (GO:0045087) 3.553IL23R, IL36RN, HLA-C
cellular process (GO:0009987) 0.263CARD14, TRAF3IP2, HLA-C
defense response (GO:0006952) 2.783IL23R, IL36RN, HLA-C
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.823IL23R, AP1S3, TRAF3IP2
response to stress (GO:0006950) 1.83IL23R, IL36RN, HLA-C
positive regulation of intracellular signal transduction (GO:1902533) 2.953IL23R, CARD14, TRAF3IP2
regulation of intracellular signal transduction (GO:1902531) 2.313IL23R, CARD14, TRAF3IP2
multi-organism process (GO:0051704) 2.653IL23R, IL36RN, HLA-C
regulation of response to stress (GO:0080134) 2.533IL23R, AP1S3, TRAF3IP2
regulation of multi-organism process (GO:0043900) 3.63IL23R, AP1S3, TRAF3IP2
regulation of immune effector process (GO:0002697) 3.713IL23R, AP1S3, TRAF3IP2
positive regulation of cellular process (GO:0048522) 1.33IL23R, CARD14, TRAF3IP2
protein localization (GO:0008104) 2.362AP1S3, TRAF3IP2
regulation of phosphate metabolic process (GO:0019220) 2.352IL23R, CARD14
regulation of primary metabolic process (GO:0080090) 1.082IL23R, CARD14
regulation of metabolic process (GO:0019222) 1.022IL23R, CARD14
positive regulation of cellular metabolic process (GO:0031325) 1.812IL23R, CARD14
regulation of interferon-gamma production (GO:0032649) 5.212IL23R, IL36RN
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632AP1S3, HLA-C
regulation of phosphorus metabolic process (GO:0051174) 2.352IL23R, CARD14
antigen processing and presentation of peptide antigen (GO:0048002) 4.562AP1S3, HLA-C
cell death (GO:0008219) 3.052CARD14, TRAF3IP2
single-organism process (GO:0044699) 0.482CARD14, TRAF3IP2
positive regulation of metabolic process (GO:0009893) 1.742IL23R, CARD14
establishment of localization (GO:0051234) 1.482AP1S3, TRAF3IP2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812IL23R, CARD14
response to external biotic stimulus (GO:0043207) 3.132IL23R, IL36RN
positive regulation of phosphorus metabolic process (GO:0010562) 2.782IL23R, CARD14
regulation of kinase activity (GO:0043549) 3.072IL23R, CARD14
regulation of protein metabolic process (GO:0051246) 1.932IL23R, CARD14
positive regulation of protein metabolic process (GO:0051247) 2.432IL23R, CARD14
positive regulation of cellular protein metabolic process (GO:0032270) 2.492IL23R, CARD14
transport (GO:0006810) 1.512AP1S3, TRAF3IP2
regulation of protein modification process (GO:0031399) 2.322IL23R, CARD14
regulation of molecular function (GO:0065009) 1.782IL23R, CARD14
macromolecule localization (GO:0033036) 2.342AP1S3, TRAF3IP2
apoptotic process (GO:0006915) 3.142CARD14, TRAF3IP2
antigen processing and presentation (GO:0019882) 4.362AP1S3, HLA-C
regulation of catalytic activity (GO:0050790) 1.972IL23R, CARD14
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592AP1S3, HLA-C
positive regulation of phosphate metabolic process (GO:0045937) 2.782IL23R, CARD14
regulation of macromolecule metabolic process (GO:0060255) 1.082IL23R, CARD14
regulation of cellular metabolic process (GO:0031323) 1.072IL23R, CARD14
regulation of protein kinase activity (GO:0045859) 3.152IL23R, CARD14
regulation of defense response to virus by host (GO:0050691) 4.892IL23R, TRAF3IP2
establishment of protein localization (GO:0045184) 2.532AP1S3, TRAF3IP2
programmed cell death (GO:0012501) 3.12CARD14, TRAF3IP2
regulation of immune response (GO:0050776) 2.982IL23R, HLA-C
single-organism cellular process (GO:0044763) 0.652CARD14, TRAF3IP2
regulation of multicellular organismal process (GO:0051239) 1.872IL23R, IL36RN
humoral immune response (GO:0006959) 4.592IL36RN, TRAF3IP2
response to other organism (GO:0051707) 3.482IL23R, IL36RN
localization (GO:0051179) 1.42AP1S3, TRAF3IP2
regulation of phosphorylation (GO:0042325) 2.52IL23R, CARD14
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) 5.142AP1S3, HLA-C
positive regulation of phosphorylation (GO:0042327) 2.92IL23R, CARD14
regulation of cellular protein metabolic process (GO:0032268) 1.992IL23R, CARD14
response to biotic stimulus (GO:0009607) 3.092IL23R, IL36RN
organic substance transport (GO:0071702) 2.152AP1S3, TRAF3IP2
response to external stimulus (GO:0009605) 2.552IL23R, IL36RN
negative regulation of multicellular organismal process (GO:0051241) 2.842IL23R, IL36RN
positive regulation of protein modification process (GO:0031401) 2.72IL23R, CARD14
regulation of transferase activity (GO:0051338) 2.882IL23R, CARD14
regulation of cytokine production (GO:0001817) 3.42IL23R, IL36RN
positive regulation of defense response to virus by host (GO:0002230) 4.982IL23R, TRAF3IP2
negative regulation of cellular process (GO:0048523) 1.412IL36RN, CARD14
protein transport (GO:0015031) 2.622AP1S3, TRAF3IP2
defense response to other organism (GO:0098542) 3.752IL23R, IL36RN
regulation of protein phosphorylation (GO:0001932) 2.572IL23R, CARD14
positive regulation of protein phosphorylation (GO:0001934) 2.952IL23R, CARD14
negative regulation of cytokine production (GO:0001818) 4.42IL23R, IL36RN
regulation of interleukin-17 production (GO:0032660) 6.642IL23R, IL36RN

NET-GE enrichment

Term New enriched termICP valueGenes
cell surface receptor signaling pathway (GO:0007166) -2.090.0IL23R, CARD14, HLA-C
cellular response to organic substance (GO:0071310) NEW2.780.0IL23R, CARD14, HLA-C
regulation of response to stimulus (GO:0048583) -1.540.0IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
regulation of adaptive immune response (GO:0002819) NEW4.910.0IL23R, HLA-C
regulation of lymphocyte mediated immunity (GO:0002706) NEW4.990.0IL23R, HLA-C
positive regulation of leukocyte mediated immunity (GO:0002705) NEW5.320.0IL23R, HLA-C
regulation of leukocyte mediated immunity (GO:0002703) NEW4.70.0IL23R, HLA-C
signal transduction (GO:0007165) -1.280.0IL23R, CARD14, TRAF3IP2, HLA-C
cellular response to chemical stimulus (GO:0070887) NEW2.570.0IL23R, CARD14, HLA-C
regulation of cell killing (GO:0031341) NEW5.60.0IL23R, HLA-C
positive regulation of cell killing (GO:0031343) NEW6.090.0IL23R, HLA-C
regulation of biological process (GO:0050789) -0.450.009IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
regulation of T cell mediated immunity (GO:0002709) NEW5.760.0IL23R, HLA-C
cytokine-mediated signaling pathway (GO:0019221) -3.60.0IL23R, CARD14, TRAF3IP2, HLA-C
cellular response to stimulus (GO:0051716) NEW1.970.0IL23R, CARD14, TRAF3IP2, HLA-C
antigen processing and presentation of peptide antigen (GO:0048002) -4.560.0AP1S3, HLA-C
antigen processing and presentation of exogenous peptide antigen (GO:0002478) -4.630.0AP1S3, HLA-C
interspecies interaction between organisms (GO:0044419) NEW3.080.0AP1S3, HLA-C
positive regulation of immune system process (GO:0002684) NEW2.960.0IL23R, HLA-C
regulation of immune system process (GO:0002682) -2.50.0IL23R, AP1S3, HLA-C
positive regulation of biological process (GO:0048518) -1.20.0IL23R, CARD14, TRAF3IP2, HLA-C
biological regulation (GO:0065007) -0.390.022IL36RN, HLA-C, CARD14, AP1S3, IL23R, TRAF3IP2
positive regulation of lymphocyte mediated immunity (GO:0002708) NEW5.490.0IL23R, HLA-C
antigen processing and presentation (GO:0019882) -4.360.0AP1S3, HLA-C
positive regulation of response to stimulus (GO:0048584) -2.180.0IL23R, TRAF3IP2, HLA-C
antigen processing and presentation of exogenous antigen (GO:0019884) -4.590.0AP1S3, HLA-C
response to cytokine (GO:0034097) NEW3.840.0IL23R, CARD14, TRAF3IP2, HLA-C
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002824) NEW5.480.0IL23R, HLA-C
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002822) NEW4.990.0IL23R, HLA-C
response to interferon-gamma (GO:0034341) NEW5.40.0IL23R, HLA-C
positive regulation of T cell mediated immunity (GO:0002711) NEW6.230.0IL23R, HLA-C
multi-organism cellular process (GO:0044764) NEW3.140.0AP1S3, HLA-C
immune response (GO:0006955) -2.860.0IL36RN, TRAF3IP2, HLA-C
response to chemical (GO:0042221) NEW1.980.0IL23R, CARD14, HLA-C
positive regulation of adaptive immune response (GO:0002821) NEW5.420.0IL23R, HLA-C
response to organic substance (GO:0010033) NEW2.20.0IL23R, CARD14, HLA-C
multi-organism process (GO:0051704) -2.650.0IL23R, IL36RN, AP1S3, HLA-C
regulation of immune response (GO:0050776) -2.980.0IL23R, HLA-C
cellular response to cytokine stimulus (GO:0071345) NEW4.330.0IL23R, CARD14, TRAF3IP2, HLA-C
response to stimulus (GO:0050896) -1.220.0IL23R, IL36RN, CARD14, TRAF3IP2, HLA-C
positive regulation of immune response (GO:0050778) NEW3.40.0IL23R, HLA-C
immune system process (GO:0002376) -2.290.0IL36RN, AP1S3, TRAF3IP2, HLA-C
positive regulation of leukocyte mediated cytotoxicity (GO:0001912) NEW6.230.0IL23R, HLA-C
regulation of immune effector process (GO:0002697) -3.710.0IL23R, AP1S3, HLA-C
regulation of leukocyte mediated cytotoxicity (GO:0001910) NEW5.780.0IL23R, HLA-C
positive regulation of T cell mediated cytotoxicity (GO:0001916) NEW6.960.0IL23R, HLA-C
viral process (GO:0016032) NEW3.150.0AP1S3, HLA-C
regulation of T cell mediated cytotoxicity (GO:0001914) NEW6.590.0IL23R, HLA-C
symbiosis, encompassing mutualism through parasitism (GO:0044403) NEW3.150.0AP1S3, HLA-C
positive regulation of immune effector process (GO:0002699) NEW4.690.0IL23R, HLA-C
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.115IL23R, CARD14, AP1S3, TRAF3IP2, HLA-C
membrane (GO:0016020) 0.684IL23R, AP1S3, CARD14, HLA-C
protein complex (GO:0043234) 1.513IL23R, AP1S3, HLA-C
macromolecular complex (GO:0032991) 1.353IL23R, AP1S3, HLA-C
membrane protein complex (GO:0098796) 2.843IL23R, AP1S3, HLA-C
plasma membrane (GO:0005886) 1.393IL23R, CARD14, HLA-C
intracellular part (GO:0044424) 0.283AP1S3, CARD14, HLA-C
membrane part (GO:0044425) 0.953IL23R, AP1S3, HLA-C
extracellular region part (GO:0044421) 1.572IL36RN, HLA-C
intracellular organelle (GO:0043229) 0.512AP1S3, HLA-C
membrane-bounded organelle (GO:0043227) 0.472AP1S3, HLA-C
organelle (GO:0043226) 0.42AP1S3, HLA-C
intrinsic component of membrane (GO:0031224) 1.132IL23R, HLA-C
plasma membrane protein complex (GO:0098797) 3.552IL23R, HLA-C
endocytic vesicle membrane (GO:0030666) 4.822AP1S3, HLA-C
organelle membrane (GO:0031090) 1.972AP1S3, HLA-C
coated vesicle membrane (GO:0030662) 5.02AP1S3, HLA-C
integral component of membrane (GO:0016021) 1.142IL23R, HLA-C
vacuolar membrane (GO:0005774) 3.452AP1S3, HLA-C
cytoplasmic vesicle part (GO:0044433) 3.412AP1S3, HLA-C
Golgi apparatus part (GO:0044431) 3.02AP1S3, HLA-C
vacuolar part (GO:0044437) 3.262AP1S3, HLA-C
plasma membrane part (GO:0044459) 1.952IL23R, HLA-C
Golgi apparatus (GO:0005794) 2.72AP1S3, HLA-C
bounding membrane of organelle (GO:0098588) 2.392AP1S3, HLA-C
cytoplasmic vesicle membrane (GO:0030659) 3.672AP1S3, HLA-C
vesicle membrane (GO:0012506) 3.632AP1S3, HLA-C
vesicle (GO:0031982) 1.642AP1S3, HLA-C
intracellular membrane-bounded organelle (GO:0043231) 0.62AP1S3, HLA-C
Golgi membrane (GO:0000139) 3.282AP1S3, HLA-C
intracellular organelle part (GO:0044446) 0.812AP1S3, HLA-C
cytoplasmic part (GO:0044444) 0.822AP1S3, HLA-C
extracellular region (GO:0005576) 2.182IL36RN, HLA-C
whole membrane (GO:0098805) 2.852AP1S3, HLA-C
organelle part (GO:0044422) 0.792AP1S3, HLA-C

NET-GE enrichment

Term New enriched termICP valueGenes
organelle membrane (GO:0031090) -1.970.0AP1S3, HLA-C
membrane (GO:0016020) -0.680.003AP1S3, CARD14, HLA-C
cytoplasmic vesicle part (GO:0044433) -3.410.0AP1S3, HLA-C
Golgi apparatus part (GO:0044431) -3.00.0AP1S3, HLA-C
plasma membrane part (GO:0044459) -1.950.0IL23R, TRAF3IP2, HLA-C
bounding membrane of organelle (GO:0098588) -2.390.0AP1S3, HLA-C
protein complex (GO:0043234) -1.510.004IL23R, AP1S3, CARD14, HLA-C
cell surface (GO:0009986) NEW3.440.0TRAF3IP2, HLA-C
cytoplasmic vesicle membrane (GO:0030659) -3.670.0AP1S3, HLA-C
vesicle membrane (GO:0012506) -3.630.0AP1S3, HLA-C
plasma membrane (GO:0005886) -1.390.0CARD14, TRAF3IP2, HLA-C
macromolecular complex (GO:0032991) -1.350.0IL23R, AP1S3, CARD14, HLA-C
Golgi membrane (GO:0000139) -3.280.0AP1S3, HLA-C
intracellular organelle part (GO:0044446) -0.810.011AP1S3, HLA-C
cytoplasmic part (GO:0044444) -0.820.031AP1S3, HLA-C
membrane part (GO:0044425) -0.950.001IL23R, AP1S3, HLA-C
organelle part (GO:0044422) -0.790.016AP1S3, HLA-C